Rachel Henry Bonami, Ph.D.

Assistant Professor

rachel.h.bonami@vanderbilt.edu
Faculty Appointments
Assistant Professor of Medicine
Education
Ph.D., Microbiology and Immunology, Vanderbilt University, Nashville, TennesseeB.S., Microbiology and Cell Sciences, University of Florida, Gainesville, Florida
Office Address
MCN T3207F
1161 21st Ave. S
Nashville, TN 37232
Research Description
Autoantigen specific T and B lymphocytes interact to promote autoimmune diseases such as type 1 diabetes and rheumatoid arthritis. My research is focused on identifying and selectively blocking these cognate interactions to prevent disease. My current investigations also include the dynamic interplay that occurs between lymphocytes and the microbiome, and how this might be modulated to prevent autoimmune disease.
Research Keywords
B cell, T cell, autoimmunity, type 1 diabetes, arthritis, microbiome
Publications
Nyhoff LE, Barron BL, Johnson EM, Bonami RH, Maseda D, Fensterheim BA, Han W, Blackwell TS, Crofford LJ, Kendall PL. Bruton's Tyrosine Kinase Deficiency Inhibits Autoimmune Arthritis in Mice but Fails to Block Immune Complex-Mediated Inflammatory Arthritis. Arthritis & rheumatology (Hoboken, N.J.). 2016 Aug; 68(8): 1856-68. PMID: 26945549, DOI: 10.1002/art.39657, ISSN: 2326-5205.

Itani HA, McMaster WG, Saleh MA, Nazarewicz RR, Mikolajczyk TP, Kaszuba AM, Konior A, Prejbisz A, Januszewicz A, Norlander AE, Chen W, Bonami RH, Marshall AF, Poffenberger G, Weyand CM, Madhur MS, Moore DJ, Harrison DG, Guzik TJ. Activation of Human T Cells in Hypertension: Studies of Humanized Mice and Hypertensive Humans. Hypertension [print-electronic]. 2016 Jul; 68(1): 123-32. PMID: 27217403, PMCID: PMC4900908, PII: HYPERTENSIONAHA.116.07237, DOI: 10.1161/HYPERTENSIONAHA.116.07237, ISSN: 1524-4563.

Bonami RH, Thomas JW. Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes-Prone Mice. J. Immunol [print-electronic]. 2015 Nov 11/15/2015; 195(10): 4730-41. PMID: 26432895, PMCID: PMC4637270, PII: jimmunol.1500438, DOI: 10.4049/jimmunol.1500438, ISSN: 1550-6606.

Williams JM, Bonami RH, Hulbert C, Thomas JW. Reversing Tolerance in Isotype Switch-Competent Anti-Insulin B Lymphocytes. J. Immunol [print-electronic]. 2015 Aug 8/1/2015; 195(3): 853-64. PMID: 26109644, PMCID: PMC4506889, PII: jimmunol.1403114, DOI: 10.4049/jimmunol.1403114, ISSN: 1550-6606.

Case JB, Bonami RH, Nyhoff LE, Steinberg HE, Sullivan AM, Kendall PL. Bruton's Tyrosine Kinase Synergizes with Notch2 To Govern Marginal Zone B Cells in Nonobese Diabetic Mice. J. Immunol [print-electronic]. 2015 Jul 7/1/2015; 195(1): 61-70. PMID: 26034172, PMCID: PMC4551465, PII: jimmunol.1400803, DOI: 10.4049/jimmunol.1400803, ISSN: 1550-6606.

Bonami RH, Wolfle WT, Thomas JW, Kendall PL. NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. Mol. Immunol [print-electronic]. 2014 Dec; 62(2): 321-8. PMID: 24507801, PMCID: PMC4125564, PII: S0161-5890(14)00012-1, DOI: 10.1016/j.molimm.2014.01.003, ISSN: 1872-9142.

Maseda D, Bonami RH, Crofford LJ. Regulation of B lymphocytes and plasma cells by innate immune mechanisms and stromal cells in rheumatoid arthritis. Expert Rev Clin Immunol [print-electronic]. 2014 Jun; 10(6): 747-62. PMID: 24734886, DOI: 10.1586/1744666X.2014.907744, ISSN: 1744-8409.

Bonami RH, Sullivan AM, Case JB, Steinberg HE, Hoek KL, Khan WN, Kendall PL. Bruton's tyrosine kinase promotes persistence of mature anti-insulin B cells. J. Immunol [print-electronic]. 2014 Feb 2/15/2014; 192(4): 1459-70. PMID: 24453243, PMCID: PMC4083749, PII: jimmunol.1300125, DOI: 10.4049/jimmunol.1300125, ISSN: 1550-6606.

Henry-Bonami RA, Williams JM, Rachakonda AB, Karamali M, Kendall PL, Thomas JW. B lymphocyte "original sin" in the bone marrow enhances islet autoreactivity in type 1 diabetes-prone nonobese diabetic mice. J. Immunol [print-electronic]. 2013 Jun 6/15/2013; 190(12): 5992-6003. PMID: 23677466, PMCID: PMC3679359, PII: jimmunol.1201359, DOI: 10.4049/jimmunol.1201359, ISSN: 1550-6606.

Henry RA, Kendall PL, Thomas JW. Autoantigen-specific B-cell depletion overcomes failed immune tolerance in type 1 diabetes. Diabetes [print-electronic]. 2012 Aug; 61(8): 2037-44. PMID: 22698916, PMCID: PMC3402296, PII: db11-1746, DOI: 10.2337/db11-1746, ISSN: 1939-327X.

Henry RA, Kendall PL. CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice. J. Immunol [print-electronic]. 2010 Aug 8/1/2010; 185(3): 1460-5. PMID: 20574003, PMCID: PMC3824617, PII: jimmunol.0903710, DOI: 10.4049/jimmunol.0903710, ISSN: 1550-6606.

Henry RA, Kendall PL, Woodward EJ, Hulbert C, Thomas JW. Vkappa polymorphisms in NOD mice are spread throughout the entire immunoglobulin kappa locus and are shared by other autoimmune strains. Immunogenetics [print-electronic]. 2010 Aug; 62(8): 507-20. PMID: 20556377, PMCID: PMC2970566, DOI: 10.1007/s00251-010-0457-9, ISSN: 1432-1211.

Henry RA, Acevedo-Suárez CA, Thomas JW. Functional silencing is initiated and maintained in immature anti-insulin B cells. J. Immunol. 2009 Mar 3/15/2009; 182(6): 3432-9. PMID: 19265121, PMCID: PMC3845364, PII: 182/6/3432, DOI: 10.4049/jimmunol.0803121, ISSN: 1550-6606.

Antar AA, Konopka JL, Campbell JA, Henry RA, Perdigoto AL, Carter BD, Pozzi A, Abel TW, Dermody TS. Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Cell Host Microbe. 2009 Jan 1/22/2009; 5(1): 59-71. PMID: 19154988, PMCID: PMC2642927, PII: S1931-3128(08)00398-3, DOI: 10.1016/j.chom.2008.12.001, ISSN: 1934-6069.