Bryan J. Venters, Ph.D.

Assistant Professor

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Faculty Appointments
Assistant Professor of Molecular Physiology & Biophysics
Ph.D., Biochemistry, Microbiology and Molecular Biology, Pennsylvania State University, University Park, PennsylvaniaB.S., Oklahoma State University, Stillwater, Oklahoma
Office Address
746 RRB, Robinson Research Building
2200 Pierce Ave
Nashville, TN 37232
Research Description
A fundamental question in molecular biology is how human disease is programmed into the genome. The overarching goal of my laboratory is to elucidate the transcription regulatory networks underlying oncogenic signaling pathways. STAT transcription factors in the JAK-STAT pathway (Janus Kinase-Signal Transducer and Activator of Transcription) are among the most frequently activated oncogenic proteins in cancer cells. My current research is focused on discovering how the JAK-STAT pathway is involved in the disease process using genetic, molecular, and next-gen sequencing approaches.

The goals of some current projects in my laboratory are to:

- Understand how STATs direct aberrant transcriptional programs in leukemia using stat-of-the-art functional genomics approaches

- Dissect the functional interdependencies among STATs on a genome-wide scale

- Identifying regulatory complexes that are recruited by the STAT transcription factors

- Discover novel molecular signatures in clinical samples with the future goal to better predict patient prognosis and identify new therapeutic targets
Research Keywords
The goal of my research is to understand the transcriptional mechanisms underpinning the JAK-STAT signaling pathway that lead to human disease and cancer.
Zhao Y, Liu Q, Acharya P, Stengel KR, Sheng Q, Zhou X, Kwak H, Fischer MA, Bradner JE, Strickland SA, Mohan SR, Savona MR, Venters BJ, Zhou MM, Lis JT, Hiebert SW. High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML. Cell Rep [print-electronic]. 2016 Aug 8/16/2016; 16(7): 2003-16. PMID: 27498870, PMCID: PMC4996374, PII: S2211-1247(16)30950-0, DOI: 10.1016/j.celrep.2016.07.032, ISSN: 2211-1247.

Marshall CB, Mays DJ, Beeler JS, Rosenbluth JM, Boyd KL, Santos Guasch GL, Shaver TM, Tang LJ, Liu Q, Shyr Y, Venters BJ, Magnuson MA, Pietenpol JA. P73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network. Cell Rep [print-electronic]. 2016 Mar 3/15/2016; 14(10): 2289-300. PMID: 26947080, PMCID: PMC4794398, PII: S2211-1247(16)30138-3, DOI: 10.1016/j.celrep.2016.02.035, ISSN: 2211-1247.

Venters BJ, Irvin JD, Gramlich P, Pugh BF. Genome-wide transcriptional dependence on conserved regions of Mot1. Mol. Cell. Biol [print-electronic]. 2011 Jun; 31(11): 2253-61. PMID: 21444714, PMCID: PMC3133245, PII: MCB.01464-10, DOI: 10.1128/MCB.01464-10, ISSN: 1098-5549.

Venters BJ, Wachi S, Mavrich TN, Andersen BE, Jena P, Sinnamon AJ, Jain P, Rolleri NS, Jiang C, Hemeryck-Walsh C, Pugh BF. A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol. Cell. 2011 Feb 2/18/2011; 41(4): 480-92. PMID: 21329885, PMCID: PMC3057419, PII: S1097-2765(11)00042-6, DOI: 10.1016/j.molcel.2011.01.015, ISSN: 1097-4164.

Venters BJ, Pugh BF. How eukaryotic genes are transcribed. Crit. Rev. Biochem. Mol. Biol. 2009 Jun; 44(2-3): 117-41. PMID: 19514890, PMCID: PMC2718758, DOI: 10.1080/10409230902858785, ISSN: 1549-7798.

Venters BJ, Pugh BF. A canonical promoter organization of the transcription machinery and its regulators in the Saccharomyces genome. Genome Res [print-electronic]. 2009 Mar; 19(3): 360-71. PMID: 19124666, PMCID: PMC2661807, PII: gr.084970.108, DOI: 10.1101/gr.084970.108, ISSN: 1088-9051.

Yao H, Li P, Venters BJ, Zheng S, Thompson PR, Pugh BF, Wang Y. Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis. J. Biol. Chem [print-electronic]. 2008 Jul 7/18/2008; 283(29): 20060-8. PMID: 18499678, PMCID: PMC2459274, PII: M802940200, DOI: 10.1074/jbc.M802940200, ISSN: 0021-9258.

Mavrich TN, Ioshikhes IP, Venters BJ, Jiang C, Tomsho LP, Qi J, Schuster SC, Albert I, Pugh BF. A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome. Genome Res [print-electronic]. 2008 Jul; 18(7): 1073-83. PMID: 18550805, PMCID: PMC2493396, PII: gr.078261.108, DOI: 10.1101/gr.078261.108, ISSN: 1088-9051.

Mavrich TN, Jiang C, Ioshikhes IP, Li X, Venters BJ, Zanton SJ, Tomsho LP, Qi J, Glaser RL, Schuster SC, Gilmour DS, Albert I, Pugh BF. Nucleosome organization in the Drosophila genome. Nature [print-electronic]. 2008 May 5/15/2008; 453(7193): 358-62. PMID: 18408708, PMCID: PMC2735122, PII: nature06929, DOI: 10.1038/nature06929, ISSN: 1476-4687.

Lee C, Li X, Hechmer A, Eisen M, Biggin MD, Venters BJ, Jiang C, Li J, Pugh BF, Gilmour DS. NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila. Mol. Cell. Biol [print-electronic]. 2008 May; 28(10): 3290-300. PMID: 18332113, PMCID: PMC2423147, PII: MCB.02224-07, DOI: 10.1128/MCB.02224-07, ISSN: 1098-5549.

Cheng L, Naumann TA, Horswill AR, Hong SJ, Venters BJ, Tomsho JW, Benkovic SJ, Keiler KC. Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease. Protein Sci [print-electronic]. 2007 Aug; 16(8): 1535-42. PMID: 17600141, PMCID: PMC2203360, PII: ps.072933007, DOI: 10.1110/ps.072933007, ISSN: 0961-8368.

Venters BJ, Pugh BF. Chromatin meets RNA polymerase II. Genome Biol. 2007; 8(11): 319. PMID: 18001505, PMCID: PMC2258197, PII: gb-2007-8-11-319, DOI: 10.1186/gb-2007-8-11-319, ISSN: 1474-760X.

Lessner FH, Venters BJ, Keiler KC. Proteolytic adaptor for transfer-messenger RNA-tagged proteins from alpha-proteobacteria. J. Bacteriol [print-electronic]. 2007 Jan; 189(1): 272-5. PMID: 17085560, PMCID: PMC1797230, PII: JB.01387-06, DOI: 10.1128/JB.01387-06, ISSN: 0021-9193.

Available Postdoctoral Position Details
Posted: 11/16/2015
Our laboratory is seeking a postdoctoral candidate who is interested in research that uses functional genomic approaches to investigate erythropoietin(Epo)-dependent gene regulatory pathways in erythroid differentiation. Suitable applicants must have experience analyzing next-gen sequencing data, use of command line bioinformatics tools, and preferably with programming experience with Python or Perl.

To apply please send your CV, a brief description on why you are interested in the position, and names/contact info for 2-3 references to:
Dr. Bryan Venters (