Kasey C. Vickers, Ph.D.

Assistant Professor

Faculty Appointments
Assistant Professor of Medicine Assistant Professor of Molecular Physiology and Biophysics
Ph.D., Cardiovascular Sciences, Baylor College of Medicine, Houston, TexasB.S., Texas Tech University, Lubbock, Texas
Research Description
The central goal of the Vickers lab is to discover gene regulatory modules that can be manipulated to prevent and treat cardiometabolic diseases. Specifically, our lab investigates small RNA-mediated gene regulation in lipid and lipoprotein metabolism. Many projects in the lab aim to determine the biochemical mechanisms underlying small RNA intercellular communication. Due to the applicability of small RNA cell-to-cell communication, we are defining the biological impact in multiple diseases, including dyslipidemia, atherosclerosis, type 2 diabetes, chronic kidney disease, and autoimmunity.

Research Keywords
Cardiovascular Disease; Atherosclerosis; Chronic Kidney Disease; Autoimmunity; Type 2 Diabetes; Inflammation; Metabolism; Cholesterol; Glucose; Lipoproteins; HDL; LDL; VLDL; microRNAs; non-coding small RNAs; tRNA-derived small RNAs
Vickers KC, Rye KA, Tabet F. MicroRNAs in the onset and development of cardiovascular disease. Clin. Sci. 2014 Feb; 126(3): 183-94. PMID: 24102098, PMCID: PMC3873876, PII: CS20130203, DOI: 10.1042/CS20130203, ISSN: 1470-8736.

Tabet F, Vickers KC, Cuesta Torres LF, Wiese CB, Shoucri BM, Lambert G, Catherinet C, Prado-Lourenco L, Levin MG, Thacker S, Sethupathy P, Barter PJ, Remaley AT, Rye KA. HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells. Nat Commun. 2014; 5: 3292. PMID: 24576947, PMCID: PMC4189962, PII: ncomms4292, DOI: 10.1038/ncomms4292, ISSN: 2041-1723.

Vickers KC, Remaley AT. HDL and cholesterol: life after the divorce?. J. Lipid Res [print-electronic]. 2014 Jan; 55(1): 4-12. PMID: 23515282, PMCID: PMC3927467, PII: jlr.R035964, DOI: 10.1194/jlr.R035964, ISSN: 0022-2275.

Vickers KC, Moore KJ. Small RNA overcomes the challenges of therapeutic targeting of microsomal triglyceride transfer protein. Circ. Res. 2013 Nov 11/8/2013; 113(11): 1189-91. PMID: 24201112, PMCID: PMC4043302, PII: CIRCRESAHA.113.302732, DOI: 10.1161/CIRCRESAHA.113.302732, ISSN: 1524-4571.

Vickers KC, Sethupathy P, Baran-Gale J, Remaley AT. Complexity of microRNA function and the role of isomiRs in lipid homeostasis. J. Lipid Res [print-electronic]. 2013 May; 54(5): 1182-91. PMID: 23505317, PMCID: PMC3622316, PII: jlr.R034801, DOI: 10.1194/jlr.R034801, ISSN: 0022-2275.

Feng Q, Vickers KC, Anderson MP, Levin MG, Chen W, Harrison DG, Wilke RA. A common functional promoter variant links CNR1 gene expression to HDL cholesterol level. Nat Commun. 2013; 4: 1973. PMID: 23748922, PMCID: PMC3873874, PII: ncomms2973, DOI: 10.1038/ncomms2973, ISSN: 2041-1723.