Kasey C. Vickers, Ph.D.

Assistant Professor

kasey.c.vickers@vanderbilt.edu
Faculty Appointments
Assistant Professor of Medicine Assistant Professor of Molecular Physiology and Biophysics
Education
Ph.D., Cardiovascular Sciences, Baylor College of Medicine, Houston, TexasB.S., Texas Tech University, Lubbock, Texas
Research Description
To investigate mechanisms and consequences of HDL microRNA communication and systemic homeostasis. Short term goals include the characterization of microRNA regulatory modules controlling cholesterol biosynthesis. Moreover, we aim to determine i.) How microRNAs are selected and exported to HDL, ii.) How microRNAs are transported on HDL and altered in disease, and iii.) How microRNAs are transferred to recipient cells and regulate genes related to cholesterol and lipoprotein homeostasis.
Research Keywords
Cardiovascular Disease; Lipoproteins; HDL; microRNAs
Publications
Vickers KC, Rye KA, Tabet F. MicroRNAs in the onset and development of cardiovascular disease. Clin. Sci. 2014 Feb; 126(3): 183-94. PMID: 24102098, PMCID: PMC3873876, PII: CS20130203, DOI: 10.1042/CS20130203, ISSN: 1470-8736.

Tabet F, Vickers KC, Cuesta Torres LF, Wiese CB, Shoucri BM, Lambert G, Catherinet C, Prado-Lourenco L, Levin MG, Thacker S, Sethupathy P, Barter PJ, Remaley AT, Rye KA. HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells. Nat Commun. 2014; 5: 3292. PMID: 24576947, PMCID: PMC4189962, PII: ncomms4292, DOI: 10.1038/ncomms4292, ISSN: 2041-1723.

Vickers KC, Remaley AT. HDL and cholesterol: life after the divorce?. J. Lipid Res [print-electronic]. 2014 Jan; 55(1): 4-12. PMID: 23515282, PMCID: PMC3927467, PII: jlr.R035964, DOI: 10.1194/jlr.R035964, ISSN: 0022-2275.

Vickers KC, Moore KJ. Small RNA overcomes the challenges of therapeutic targeting of microsomal triglyceride transfer protein. Circ. Res. 2013 Nov 11/8/2013; 113(11): 1189-91. PMID: 24201112, PMCID: PMC4043302, PII: CIRCRESAHA.113.302732, DOI: 10.1161/CIRCRESAHA.113.302732, ISSN: 1524-4571.

Vickers KC, Sethupathy P, Baran-Gale J, Remaley AT. Complexity of microRNA function and the role of isomiRs in lipid homeostasis. J. Lipid Res [print-electronic]. 2013 May; 54(5): 1182-91. PMID: 23505317, PMCID: PMC3622316, PII: jlr.R034801, DOI: 10.1194/jlr.R034801, ISSN: 0022-2275.

Feng Q, Vickers KC, Anderson MP, Levin MG, Chen W, Harrison DG, Wilke RA. A common functional promoter variant links CNR1 gene expression to HDL cholesterol level. Nat Commun. 2013; 4: 1973. PMID: 23748922, PMCID: PMC3873874, PII: ncomms2973, DOI: 10.1038/ncomms2973, ISSN: 2041-1723.