Sergey V. Novitskiy, M.D., Ph.D.

Research Associate Professor

sergey.v.novitskiy@vanderbilt.edu
Faculty Appointments
Research Associate Professor of Medicine
Education
Ph.D., Siberian State University, Tomsk, RussiaM.D., Siberian State University, Tomsk, Russia
Office Address
PRB 612
2220 Pierce Ave
Nashville, TN 37232
Research Keywords
TGF-beta, Cancer, Immunology, Adenosine
Publications
Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat. Med [print-electronic]. 2016 May; 22(5): 497-505. PMID: 27089513, PMCID: PMC4860133, PII: nm.4082, DOI: 10.1038/nm.4082, ISSN: 1546-170X.

Jolly LA, Novitskiy S, Owens P, Massoll N, Cheng N, Fang W, Moses HL, Franco AT. Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss. Cancer Res [print-electronic]. 2016 Apr 4/1/2016; 76(7): 1804-13. PMID: 26818109, PMCID: PMC4873339, PII: 0008-5472.CAN-15-2351, DOI: 10.1158/0008-5472.CAN-15-2351, ISSN: 1538-7445.

Biktasova AK, Dudimah DF, Uzhachenko RV, Park K, Akhter A, Arasada RR, Evans JV, Novitskiy SV, Tchekneva EE, Carbone DP, Shanker A, Dikov MM. Multivalent Forms of the Notch Ligand DLL-1 Enhance Antitumor T-cell Immunity in Lung Cancer and Improve Efficacy of EGFR-Targeted Therapy. Cancer Res [print-electronic]. 2015 Nov 11/15/2015; 75(22): 4728-41. PMID: 26404003, PMCID: PMC4651735, PII: 0008-5472.CAN-14-1154, DOI: 10.1158/0008-5472.CAN-14-1154, ISSN: 1538-7445.

Pickup MW, Hover LD, Guo Y, Gorska AE, Chytil A, Novitskiy SV, Moses HL, Owens P. Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis. Oncotarget. 2015 Sep 9/8/2015; 6(26): 22890-904. PMID: 26274893, PMCID: PMC4673207, PII: 4413, DOI: 10.18632/oncotarget.4413, ISSN: 1949-2553.

Owens P, Pickup MW, Novitskiy SV, Giltnane JM, Gorska AE, Hopkins CR, Hong CC, Moses HL. Inhibition of BMP signaling suppresses metastasis in mammary cancer. Oncogene [print-electronic]. 2015 May 5/7/2015; 34(19): 2437-49. PMID: 24998846, PMCID: PMC4689138, PII: onc2014189, DOI: 10.1038/onc.2014.189, ISSN: 1476-5594.

Shaw AK, Pickup MW, Chytil A, Aakre M, Owens P, Moses HL, Novitskiy SV. TGFß signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions. PLoS ONE. 2015; 10(1): e0117908. PMID: 25629162, PMCID: PMC4309578, PII: PONE-D-14-28885, DOI: 10.1371/journal.pone.0117908, ISSN: 1932-6203.

Pickup MW, Hover LD, Polikowsky ER, Chytil A, Gorska AE, Novitskiy SV, Moses HL, Owens P. BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation. Mol Oncol [print-electronic]. 2015 Jan; 9(1): 179-91. PMID: 25205038, PMCID: PMC4277920, PII: S1574-7891(14)00186-0, DOI: 10.1016/j.molonc.2014.08.004, ISSN: 1878-0261.

Ryzhov SV, Pickup MW, Chytil A, Gorska AE, Zhang Q, Owens P, Feoktistov I, Moses HL, Novitskiy SV. Role of TGF-ß signaling in generation of CD39+CD73+ myeloid cells in tumors. J. Immunol [print-electronic]. 2014 Sep 9/15/2014; 193(6): 3155-64. PMID: 25127858, PMCID: PMC4157098, PII: jimmunol.1400578, DOI: 10.4049/jimmunol.1400578, ISSN: 1550-6606.

Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell [print-electronic]. 2014 Jun 6/16/2014; 25(6): 719-34. PMID: 24856586, PMCID: PMC4180632, PII: S1535-6108(14)00175-5, DOI: 10.1016/j.ccr.2014.04.005, ISSN: 1878-3686.

Owens P, Polikowsky H, Pickup MW, Gorska AE, Jovanovic B, Shaw AK, Novitskiy SV, Hong CC, Moses HL. Bone Morphogenetic Proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion. PLoS ONE [electronic-print]. 2013; 8(6): e67533. PMID: 23840733, PMCID: PMC3695869, PII: PONE-D-13-03284, DOI: 10.1371/journal.pone.0067533, ISSN: 1932-6203.

Novitskiy SV, Pickup MW, Chytil A, Polosukhina D, Owens P, Moses HL. Deletion of TGF-ß signaling in myeloid cells enhances their anti-tumorigenic properties. J. Leukoc. Biol [print-electronic]. 2012 Sep; 92(3): 641-51. PMID: 22685318, PMCID: PMC3427612, PII: jlb.1211639, DOI: 10.1189/jlb.1211639, ISSN: 1938-3673.

Novitskiy SV, Moses HL. Turn off the IDO: will clinical trials be successful?. Cancer Discov. 2012 Aug; 2(8): 673-5. PMID: 22886661, PII: 2/8/673, DOI: 10.1158/2159-8290.CD-12-0311, ISSN: 2159-8290.

Ryzhov S, Goldstein AE, Novitskiy SV, Blackburn MR, Biaggioni I, Feoktistov I. Role of A2B adenosine receptors in regulation of paracrine functions of stem cell antigen 1-positive cardiac stromal cells. J. Pharmacol. Exp. Ther [print-electronic]. 2012 Jun; 341(3): 764-74. PMID: 22431204, PMCID: PMC3362889, PII: jpet.111.190835, DOI: 10.1124/jpet.111.190835, ISSN: 1521-0103.

Owens P, Pickup MW, Novitskiy SV, Chytil A, Gorska AE, Aakre ME, West J, Moses HL. Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2012 Feb 2/21/2012; 109(8): 2814-9. PMID: 21576484, PMCID: PMC3286911, PII: 1101139108, DOI: 10.1073/pnas.1101139108, ISSN: 1091-6490.

Ryzhov S, Novitskiy SV, Goldstein AE, Biktasova A, Blackburn MR, Biaggioni I, Dikov MM, Feoktistov I. Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells. J. Immunol [print-electronic]. 2011 Dec 12/1/2011; 187(11): 6120-9. PMID: 22039302, PMCID: PMC3221925, PII: jimmunol.1101225, DOI: 10.4049/jimmunol.1101225, ISSN: 1550-6606.

Novitskiy SV, Pickup MW, Gorska AE, Owens P, Chytil A, Aakre M, Wu H, Shyr Y, Moses HL. TGF-ß receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms. Cancer Discov. 2011 Oct; 1(5): 430-41. PMID: 22408746, PMCID: PMC3297196, DOI: 10.1158/2159-8290.CD-11-0100, ISSN: 2159-8290.

Novitskiy SV, Csiki I, Huang Y, Johnson DH, Harth EM, Carbone DP, Dikov MM. Anti-vascular endothelial growth factor treatment in combination with chemotherapy delays hematopoietic recovery due to decreased proliferation of bone marrow hematopoietic progenitor cells. J Thorac Oncol. 2010 Sep; 5(9): 1410-5. PMID: 20683208, DOI: 10.1097/JTO.0b013e3181e59c24, ISSN: 1556-1380.

Herber DL, Cao W, Nefedova Y, Novitskiy SV, Nagaraj S, Tyurin VA, Corzo A, Cho HI, Celis E, Lennox B, Knight SC, Padhya T, McCaffrey TV, McCaffrey JC, Antonia S, Fishman M, Ferris RL, Kagan VE, Gabrilovich DI. Lipid accumulation and dendritic cell dysfunction in cancer. Nat. Med [print-electronic]. 2010 Aug; 16(8): 880-6. PMID: 20622859, PMCID: PMC2917488, PII: nm.2172, DOI: 10.1038/nm.2172, ISSN: 1546-170X.

Zaynagetdinov R, Ryzhov S, Goldstein AE, Yin H, Novitskiy SV, Goleniewska K, Polosukhin VV, Newcomb DC, Mitchell D, Morschl E, Zhou Y, Blackburn MR, Peebles RS, Biaggioni I, Feoktistov I. Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2010 May; 42(5): 564-71. PMID: 19556606, PMCID: PMC2874442, PII: 2008-0391OC, DOI: 10.1165/rcmb.2008-0391OC, ISSN: 1535-4989.

Sano H, Leboeuf JP, Novitskiy SV, Seo S, Zaja-Milatovic S, Dikov MM, Kume T. The Foxc2 transcription factor regulates tumor angiogenesis. Biochem. Biophys. Res. Commun [print-electronic]. 2010 Feb 2/5/2010; 392(2): 201-6. PMID: 20060810, PMCID: PMC2822046, PII: S0006-291X(10)00037-9, DOI: 10.1016/j.bbrc.2010.01.015, ISSN: 1090-2104.

Ryzhov S, Novitskiy SV, Zaynagetdinov R, Goldstein AE, Carbone DP, Biaggioni I, Dikov MM, Feoktistov I. Host A(2B) adenosine receptors promote carcinoma growth. Neoplasia. 2008 Sep; 10(9): 987-95. PMID: 18714400, PMCID: PMC2517644, ISSN: 1476-5586.

Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM. Adenosine receptors in regulation of dendritic cell differentiation and function. Blood [print-electronic]. 2008 Sep 9/1/2008; 112(5): 1822-31. PMID: 18559975, PMCID: PMC2518889, PII: blood-2008-02-136325, DOI: 10.1182/blood-2008-02-136325, ISSN: 1528-0020.

Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Dikov MM, Blackburn MR, Biaggioni I, Feoktistov I. Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells. J. Immunol. 2008 Jun 6/1/2008; 180(11): 7212-20. PMID: 18490720, PMCID: PMC3628765, PII: 180/11/7212, ISSN: 0022-1767.

Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Blackburn MR, Biaggioni I, Feoktistov I. Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines. J. Pharmacol. Exp. Ther [print-electronic]. 2008 Feb; 324(2): 694-700. PMID: 17965229, PII: jpet.107.131540, DOI: 10.1124/jpet.107.131540, ISSN: 1521-0103.

Huang Y, Chen X, Dikov MM, Novitskiy SV, Mosse CA, Yang L, Carbone DP. Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF. Blood [print-electronic]. 2007 Jul 7/15/2007; 110(2): 624-31. PMID: 17376891, PMCID: PMC1924481, PII: blood-2007-01-065714, DOI: 10.1182/blood-2007-01-065714, ISSN: 0006-4971.