Fred S. Lamb, M.D., Ph.D.

Professor

fred.s.lamb@vanderbilt.edu
Faculty Appointments
Professor of Pediatrics Professor of Molecular Physiology and BiophysicsCornelius Vanderbilt Chair
Education
Ph.D., University of Michigan, Ann Arbor, MichiganM.D., MEDICINE, University of Michigan, Ann Arbor, MichiganB.S., University of Michigan, Ann Arbor, Michigan
Publications
Agarwal HS, Hardison DC, Saville BR, Donahue BS, Lamb FS, Bichell DP, Harris ZL. Residual lesions in postoperative pediatric cardiac surgery patients receiving extracorporeal membrane oxygenation support. J. Thorac. Cardiovasc. Surg [print-electronic]. 2014 Jan; 147(1): 434-41. PMID: 23597724, PII: S0022-5223(13)00324-3, DOI: 10.1016/j.jtcvs.2013.03.021, ISSN: 1097-685X.

Garbrecht MR, Lamb FS. Placental HSD2 Expression and Activity Is Unaffected by Maternal Protein Consumption or Gender in C57BL/6 Mice. ISRN Endocrinol [electronic-print]. 2013; 2013: 867938. PMID: 23781346, PMCID: PMC3679810, DOI: 10.1155/2013/867938, ISSN: 2090-4630.

Ganapathi SB, Wei SG, Zaremba A, Lamb FS, Shears SB. Functional regulation of ClC-3 in the migration of vascular smooth muscle cells. Hypertension [print-electronic]. 2013 Jan; 61(1): 174-9. PMID: 23150504, PMCID: PMC3521842, PII: HYPERTENSIONAHA.112.194209, DOI: 10.1161/HYPERTENSIONAHA.112.194209, ISSN: 1524-4563.

Roghair RD, Volk KA, Lamb FS, Segar JL. Impact of maternal dexamethasone on coronary PGE(2) production and prostaglandin-dependent coronary reactivity. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2012 Sep 9/1/2012; 303(5): R513-9. PMID: 22832534, PMCID: PMC3468415, PII: ajpregu.00658.2011, DOI: 10.1152/ajpregu.00658.2011, ISSN: 1522-1490.

Lamb FS, Hook JS, Hilkin BM, Huber JN, Volk AP, Moreland JG. Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen species. J. Biol. Chem [print-electronic]. 2012 Apr 4/6/2012; 287(15): 12395-404. PMID: 22235113, PMCID: PMC3320989, PII: M111.306530, DOI: 10.1074/jbc.M111.306530, ISSN: 1083-351X.

Vucovich M, Ehinger N, Poole SD, Lamb FS, Reese J. Spontaneous Rhythmic Contractions (Vasomotion) of the Isolated, Pressurized Ductus Arteriosus of Preterm, but Not Term, Fetal Mice. EJ Neonatol Res. 2012 Jan; 2(1): 13-24. PMID: 23710420, PMCID: PMC3661283, ISSN: 2160-6072.

Roghair RD, Wemmie JA, Volk KA, Scholz TD, Lamb FS, Segar JL. Maternal antioxidant blocks programmed cardiovascular and behavioural stress responses in adult mice. Clin. Sci. 2011 Nov; 121(10): 427-36. PMID: 21615331, PMCID: PMC3677964, PII: CS20110153, DOI: 10.1042/CS20110153, ISSN: 1470-8736.

Chu X, Filali M, Stanic B, Takapoo M, Sheehan A, Bhalla R, Lamb FS, Miller FJ. A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2011 Feb; 31(2): 345-51. PMID: 21071705, PMCID: PMC3025755, PII: ATVBAHA.110.217604, DOI: 10.1161/ATVBAHA.110.217604, ISSN: 1524-4636.

Bozeat ND, Xiang SY, Ye LL, Yao TY, Duan ML, Burkin DJ, Lamb FS, Duan DD. Activation of volume regulated chloride channels protects myocardium from ischemia/reperfusion damage in second-window ischemic preconditioning. Cell. Physiol. Biochem [print-electronic]. 2011; 28(6): 1265-78. PMID: 22179014, PMCID: PMC3709186, PII: 000335858, DOI: 10.1159/000335858, ISSN: 1421-9778.

Matsuda JJ, Filali MS, Moreland JG, Miller FJ, Lamb FS. Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production. J. Biol. Chem [print-electronic]. 2010 Jul 7/23/2010; 285(30): 22864-73. PMID: 20479003, PMCID: PMC2906278, PII: M109.099838, DOI: 10.1074/jbc.M109.099838, ISSN: 1083-351X.

Volk KA, Roghair RD, Jung F, Scholz TD, Lamb FS, Segar JL. Coronary endothelial function and vascular smooth muscle proliferation are programmed by early-gestation dexamethasone exposure in sheep. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2010 Jun; 298(6): R1607-14. PMID: 20335378, PMCID: PMC2886704, PII: ajpregu.00824.2009, DOI: 10.1152/ajpregu.00824.2009, ISSN: 1522-1490.

Miller FJ, Chu X, Stanic B, Tian X, Sharma RV, Davisson RL, Lamb FS. A differential role for endocytosis in receptor-mediated activation of Nox1. Antioxid. Redox Signal. 2010 Mar 3/1/2010; 12(5): 583-93. PMID: 19737091, PMCID: PMC2861543, DOI: 10.1089/ars.2009.2857, ISSN: 1557-7716.

Matsuda JJ, Filali MS, Collins MM, Volk KA, Lamb FS. The ClC-3 Cl-/H+ antiporter becomes uncoupled at low extracellular pH. J. Biol. Chem [print-electronic]. 2010 Jan 1/22/2010; 285(4): 2569-79. PMID: 19926787, PMCID: PMC2807314, PII: M109.018002, DOI: 10.1074/jbc.M109.018002, ISSN: 1083-351X.

Lamb FS, Moreland JG, Miller FJ. Electrophysiology of reactive oxygen production in signaling endosomes. Antioxid. Redox Signal. 2009 Jun; 11(6): 1335-47. PMID: 19207039, PMCID: PMC2872256, PII: 10.1089/ARS.2009.2448, DOI: 10.1089/ARS.2009.2448, ISSN: 1557-7716.

von Bergen NH, Koppenhafer SL, Spitz DR, Volk KA, Patel SS, Roghair RD, Lamb FS, Segar JL, Scholz TD. Fetal programming alters reactive oxygen species production in sheep cardiac mitochondria. Clin. Sci. 2009 Apr; 116(8): 659-68. PMID: 19032144, PMCID: PMC3677965, PII: CS20080474, DOI: 10.1042/CS20080474, ISSN: 1470-8736.

Roghair RD, Segar JL, Volk KA, Chapleau MW, Dallas LM, Sorenson AR, Scholz TD, Lamb FS. Vascular nitric oxide and superoxide anion contribute to sex-specific programmed cardiovascular physiology in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2009 Mar; 296(3): R651-62. PMID: 19144750, PMCID: PMC2665850, PII: 90756.2008, DOI: 10.1152/ajpregu.90756.2008, ISSN: 0363-6119.

Volk AP, Heise CK, Hougen JL, Artman CM, Volk KA, Wessels D, Soll DR, Nauseef WM, Lamb FS, Moreland JG. ClC-3 and IClswell are required for normal neutrophil chemotaxis and shape change. J. Biol. Chem [print-electronic]. 2008 Dec 12/5/2008; 283(49): 34315-26. PMID: 18840613, PMCID: PMC2590705, PII: M803141200, DOI: 10.1074/jbc.M803141200, ISSN: 0021-9258.

Roghair RD, Miller FJ, Scholz TD, Lamb FS, Segar JL. Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone. Pediatr. Res. 2008 Apr; 63(4): 370-4. PMID: 18356741, PMCID: PMC3663587, PII: 00006450-200804000-00007, DOI: 10.1203/PDR.0b013e3181659bfa, ISSN: 0031-3998.

Matsuda JJ, Filali MS, Volk KA, Collins MM, Moreland JG, Lamb FS. Overexpression of CLC-3 in HEK293T cells yields novel currents that are pH dependent. Am. J. Physiol., Cell Physiol [print-electronic]. 2008 Jan; 294(1): C251-62. PMID: 17977943, PII: 00338.2007, DOI: 10.1152/ajpcell.00338.2007, ISSN: 0363-6143.

George CL, Goss KL, Meyerholz DK, Lamb FS, Snyder JM. Surfactant-associated protein A provides critical immunoprotection in neonatal mice. Infect. Immun [print-electronic]. 2008 Jan; 76(1): 380-90. PMID: 17967856, PMCID: PMC2223658, PII: IAI.01043-07, DOI: 10.1128/IAI.01043-07, ISSN: 1098-5522.