Nathan E. Brummel, M.D.


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Faculty Appointments
Instructor in Medicine
M.S.C.I., Clinical Investigation, Vanderbilt University, Nashville, TennesseeM.D., University of Missouri, Saint Louis, MissouriM.S., Creighton University, Omaha, NebraskaB.S., Creighton University, Omaha, Nebraska
Office Address
2525 West End Avenue
Nashville, TN
Research Keywords
Delirium; critical care; mechanical ventilation; sedation; aging and critical illness; long-term cognitive outcomes following critical illness; disability following critical illness
Brummel NE, Girard TD, Ely EW, Pandharipande PP, Morandi A, Hughes CG, Graves AJ, Shintani A, Murphy E, Work B, Pun BT, Boehm L, Gill TM, Dittus RS, Jackson JC. Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the Activity and Cognitive Therapy in ICU (ACT-ICU) trial. Intensive Care Med [print-electronic]. 2014 Mar; 40(3): 370-9. PMID: 24257969, PMCID: PMC3943568, DOI: 10.1007/s00134-013-3136-0, ISSN: 1432-1238.

Brummel NE, Jackson JC, Pandharipande PP, Thompson JL, Shintani AK, Dittus RS, Gill TM, Bernard GR, Ely EW, Girard TD. Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation. Crit. Care Med. 2014 Feb; 42(2): 369-77. PMID: 24158172, PMCID: PMC3947028, DOI: 10.1097/CCM.0b013e3182a645bd, ISSN: 1530-0293.

Brummel NE, Ely EW. Sedation level and the prevalence of delirium [letter]. Intensive Care Med [print-electronic]. 2014 Jan; 40(1): 135. PMID: 23982729, PMCID: PMC3869188, DOI: 10.1007/s00134-013-3083-9, ISSN: 1432-1238.

Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG, Geevarghese SK, Canonico A, Hopkins RO, Bernard GR, Dittus RS, Ely EW, . Long-term cognitive impairment after critical illness. N. Engl. J. Med. 2013 Oct 10/3/2013; 369(14): 1306-16. PMID: 24088092, PMCID: PMC3922401, DOI: 10.1056/NEJMoa1301372, ISSN: 1533-4406.

Brummel NE, Vasilevskis EE, Han JH, Boehm L, Pun BT, Ely EW. Implementing delirium screening in the ICU: secrets to success. Crit. Care Med. 2013 Sep; 41(9): 2196-208. PMID: 23896832, PMCID: PMC3772682, DOI: 10.1097/CCM.0b013e31829a6f1e, ISSN: 1530-0293.

Brummel NE, Girard TD. Preventing delirium in the intensive care unit. Crit Care Clin. 2013 Jan; 29(1): 51-65. PMID: 23182527, PMCID: PMC3508697, PII: S0749-0704(12)00084-X, DOI: 10.1016/j.ccc.2012.10.007, ISSN: 1557-8232.

Brummel NE, Jackson JC, Girard TD, Pandharipande PP, Schiro E, Work B, Pun BT, Boehm L, Gill TM, Ely EW. A combined early cognitive and physical rehabilitation program for people who are critically ill: the activity and cognitive therapy in the intensive care unit (ACT-ICU) trial. Phys Ther [print-electronic]. 2012 Dec; 92(12): 1580-92. PMID: 22577067, PMCID: PMC3513484, PII: ptj.20110414, DOI: 10.2522/ptj.20110414, ISSN: 1538-6724.

Hughes CG, Brummel NE, Vasilevskis EE, Girard TD, Pandharipande PP. Future directions of delirium research and management. Best Pract Res Clin Anaesthesiol. 2012 Sep; 26(3): 395-405. PMID: 23040289, PMCID: PMC3638881, PII: S1521-6896(12)00054-7, DOI: 10.1016/j.bpa.2012.08.004, ISSN: 1878-1608.

Jackson JC, Ely EW, Morey MC, Anderson VM, Denne LB, Clune J, Siebert CS, Archer KR, Torres R, Janz D, Schiro E, Jones J, Shintani AK, Levine B, Pun BT, Thompson J, Brummel NE, Hoenig H. Cognitive and physical rehabilitation of intensive care unit survivors: results of the RETURN randomized controlled pilot investigation. Crit. Care Med. 2012 Apr; 40(4): 1088-97. PMID: 22080631, PMCID: PMC3755871, DOI: 10.1097/CCM.0b013e3182373115, ISSN: 1530-0293.

Brummel NE, Pugh ME, Fessel JP. Outcomes in elderly intensive care unit patients, pulmonary hypertension in sickle cell disease, and total liquid ventilation for therapeutic hypothermia after cardiac arrest in rabbits. Am. J. Respir. Crit. Care Med. 2012 Feb 2/15/2012; 185(4): 453-4. PMID: 22336678, PMCID: PMC3297099, PII: 185/4/453, DOI: 10.1164/rccm.201109-1608RR, ISSN: 1535-4970.

Morandi A, Brummel NE, Ely EW. Sedation, delirium and mechanical ventilation: the 'ABCDE' approach. Curr Opin Crit Care. 2011 Feb; 17(1): 43-9. PMID: 21169829, DOI: 10.1097/MCC.0b013e3283427243, ISSN: 1531-7072.

Brummel NE, Girard TD. Are we sedating more than just the brain?. Crit Care [print-electronic]. 2011; 15(3): 163. PMID: 21672277, PMCID: PMC3218986, PII: cc10233, DOI: 10.1186/cc10233, ISSN: 1466-609X.