Hannah Hyejeong Lee, Ph.D.

Research Instructor

hannah.lee@vanderbilt.edu

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Faculty Appointments
Research Instructor in Pediatrics
Education
Ph.D., Biochemistry, Korea University, Seoul, South KoreaM.S., Biochemistry, Korea University, Seoul, South KoreaB.S., Biology, Incheon National University, Incheon, South Korea
Office Address
2220 Pierce Avenue, 397 PRB, Nashville, TN 37232
Research Description
My research interest focuses on the pharmacologic roles of drug transporters to the disposition of the anticancer drugs and cancer imaging to therapy.
Research Keywords
Pharmacology, Clinical Pharmacology, Physiology, Molecular Biology, Drug Transporters, Pharmacogenetics, Pharmacokinetics, Disposition. Anti-cancer drugs
Publications
Lee HH, Leake BF, Kim RB, Ho RH. Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance. Mol. Pharmacol [print-electronic]. 2016 Oct 10/24/2016; PMID: 27777271, PII: mol.116.105544, DOI: 10.1124/mol.116.105544, ISSN: 1521-0111.

Lee HH, Leake BF, Teft W, Tirona RG, Kim RB, Ho RH. Contribution of hepatic organic anion-transporting polypeptides to docetaxel uptake and clearance. Mol. Cancer Ther [print-electronic]. 2015 Apr; 14(4): 994-1003. PMID: 25695959, PMCID: PMC4394048, PII: 1535-7163.MCT-14-0547, DOI: 10.1158/1535-7163.MCT-14-0547, ISSN: 1538-8514.

Lee HJ, Kwon MH, Lee S, Hall RA, Yun CC, Choi I. Systematic family-wide analysis of sodium bicarbonate cotransporter NBCn1/SLC4A7 interactions with PDZ scaffold proteins. Physiol Rep [electronic-print]. 2014 May 5/1/2014; 2(5): PMID: 24844638, PMCID: PMC4098744, PII: 2/5/e12016, DOI: 10.14814/phy2.12016, ISSN: 2051-817X.

Lee HJ, Luci JJ, Tantawy MN, Lee H, Nam KT, Peterson TE, Price RR. Detecting peritoneal dissemination of ovarian cancer in mice by DWIBS. Magn Reson Imaging [print-electronic]. 2013 Feb; 31(2): 227-34. PMID: 22925604, PMCID: PMC3740967, PII: S0730-725X(12)00226-3, DOI: 10.1016/j.mri.2012.06.016, ISSN: 1873-5894.

Wilson AJ, Barham W, Saskowski J, Tikhomirov O, Chen L, Lee HJ, Yull F, Khabele D. Tracking NF-¿B activity in tumor cells during ovarian cancer progression in a syngeneic mouse model. J Ovarian Res. 2013; 6(1): 63. PMID: 24020521, PMCID: PMC3846584, PII: 1757-2215-6-63, DOI: 10.1186/1757-2215-6-63, ISSN: 1757-2215.

Lee HJ, Park HJ, Lee S, Kim YH, Choi I. The sodium-driven chloride/bicarbonate exchanger NDCBE in rat brain is upregulated by chronic metabolic acidosis. Brain Res [print-electronic]. 2011 Mar 3/4/2011; 1377: 13-20. PMID: 21195699, PII: S0006-8993(10)02750-2, DOI: 10.1016/j.brainres.2010.12.062, ISSN: 1872-6240.

Lee HJ, Tantawy MN, Nam KT, Choi I, Peterson TE, Price RR. Evaluation of an intraperitoneal ovarian cancer syngeneic mouse model using 18F-FDG MicroPET imaging. Int. J. Gynecol. Cancer. 2011 Jan; 21(1): 22-7. PMID: 21321526, PII: 00009577-201101000-00005, DOI: 10.1097/IGC.0b013e3182021bda, ISSN: 1525-1438.

Lee HJ, Joo M, Abdolrasulnia R, Young DG, Choi I, Ware LB, Blackwell TS, Christman BW. Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages. J. Biol. Chem [print-electronic]. 2010 Dec 12/17/2010; 285(51): 39655-62. PMID: 20937835, PMCID: PMC3000946, PII: M110.170290, DOI: 10.1074/jbc.M110.170290, ISSN: 1083-351X.

*Lee S, *Lee HJ, Yang HS, Thornell IM, Bevensee MO, Choi I. Sodium-bicarbonate cotransporter NBCn1 in the kidney medullary thick ascending limb cell line is upregulated under acidic conditions and enhances ammonium transport. Exp. Physiol. 2010 Sep; 95(9): 926-37. PMID: 20591978, PMCID: PMC2923243, PII: expphysiol.2010.053967, DOI: 10.1113/expphysiol.2010.053967, ISSN: 1469-445X. *Co-first authors.

Cooper DS, Lee HJ, Yang HS, Kippen J, Yun CC, Choi I. The electroneutral sodium/bicarbonate cotransporter containing an amino terminal 123-amino-acid cassette is expressed predominantly in the heart. J. Biomed. Sci [print-electronic]. 2006 Jul; 13(4): 593-5. PMID: 16547769, PMCID: PMC1488878, DOI: 10.1007/s11373-006-9078-6, ISSN: 1021-7770.

Wang D, Lee HJ, Cooper DS, Cebotaro L, Walden PD, Choi I, Yun CC. Coexpression of MAST205 inhibits the activity of Na+/H+ exchanger NHE3. Am. J. Physiol. Renal Physiol [print-electronic]. 2006 Feb; 290(2): F428-37. PMID: 16159897, PMCID: PMC1424742, PII: 00161.2005, DOI: 10.1152/ajprenal.00161.2005, ISSN: 1931-857X.

Cooper DS, Saxena NC, Yang HS, Lee HJ, Moring AG, Lee A, Choi I. Molecular and functional characterization of the electroneutral Na/HCO3 cotransporter NBCn1 in rat hippocampal neurons. J. Biol. Chem [print-electronic]. 2005 May 5/6/2005; 280(18): 17823-30. PMID: 15718246, PII: M408646200, DOI: 10.1074/jbc.M408646200, ISSN: 0021-9258.

Cheon HM, Kim HJ, Yun CY, Lee HJ, Lee IH, Shirk PD, Seo SJ. Fat body expressed yolk protein genes in Hyphantria cunea are related to the YP4 follicular epithelium yolk protein subunit gene of pyralid moths. Insect Mol. Biol. 2003 Aug; 12(4): 383-92. PMID: 12864918, PII: 422, ISSN: 0962-1075.

*Na BK, *Lee HJ, Cho SH, Lee HW, Cho JH, Kho WG, Lee JS, Lee JS, Song KJ, Park PH, Song CY, Kim TS. Expression of cysteine proteinase of Clonorchis sinensis and its use in serodiagnosis of clonorchiasis. J. Parasitol. 2002 Oct; 88(5): 1000-6. PMID: 12435144, DOI: 10.1645/0022-3395(2002)088[1000:EOCPOC]2.0.CO;2, ISSN: 0022-3395. *Co-first authors.

Lee HJ, Lee CS, Kim BS, Joo KH, Lee JS, Kim TS, Kim HR. Purification and characterization of a 7-kDa protein from Clonorchis sinensis adult worms. J. Parasitol. 2002 Jun; 88(3): 499-504. PMID: 12099418, DOI: 10.1645/0022-3395(2002)088[0499:PACOAK]2.0.CO;2, ISSN: 0022-3395.

Kim BS, Yun CY, Yeo SM, Lee HJ, Kim HR. Cloning and expression of a ferritin subunit for Galleria mellonella. Arch. Insect Biochem. Physiol. 2001 May; 47(1): 8-17. PMID: 11317331, PII: 10.1002/arch.1030, DOI: 10.1002/arch.1030, ISSN: 0739-4462.

Quan FS, Lee HJ, Chung MS, Lee JS, Rim HJ, Joo KH. Chemotherapeutic efficacy of praziquantel in rats with protective immunity to Clonorchis sinensis infection. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2000; 18(2): 98-102. PMID: 12567726, ISSN: 1000-7423.