Andrea Page-McCaw, Ph.D.

Associate Professor

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Faculty Appointments
Associate Professor of Cell and Developmental Biology Associate Professor of Cancer Biology
Ph.D., BIOLOGY, Massachusetts Institute of Technology, Cambridge, MassachusettsA.B., Harvard University, Cambridge, Massachusetts
Office Address
PMB 407935
465 21st Avenue South, U-4213A MRBIII
Nashville, TN 37240-7935
Research Description
Animals modify existing tissues to meet the demands of continuing growth and development or environmental challenge. This is known as tissue remodeling. Tissue remodeling is also required for tissue repair after insult or injury, and it goes awry during cancer when tumors usurp tissue remodeling functions to promote metastasis. My lab is especially interested in how cells interact with the extracellular environment during remodeling, both in terms of signaling and extracellular matrix. Matrix can be cleaved and removed by proteases, strengthened by cross linking, or repaired by unknown mechanisms, and we are investigating all these processes.

Drosophila melanogaster (the common fruitfly) has been an important model organism for understanding cell and developmental biology because of its advanced genetics and beautiful cytology. The extracellular environment is highly conserved in the fly, but much simpler, with less redundancy. Genetic experiments can be done rapidly and with great precision. We exploit this genomic simplicity and genetic precision to address fundamental questions about how cells interact with their extracellular environment.
Research Keywords
Cell-extracellular interactions: cell signaling, extracellular matrix, ECM, mechanical signaling, Wnt, Drosophila, optogenetics, homeostasis, genetics, cell biology, development, cell culture
Wang X, Page-McCaw A. A matrix metalloproteinase mediates long-distance attenuation of stem cell proliferation. J. Cell Biol. 2014 Sep 9/29/2014; 206(7): 923-36. PMID: 25267296, PMCID: PMC4178971, PII: jcb.201403084, DOI: 10.1083/jcb.201403084, ISSN: 1540-8140.

McCall AS, Cummings CF, Bhave G, Vanacore R, Page-McCaw A, Hudson BG. Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture. Cell. 2014 Jun 6/5/2014; 157(6): 1380-92. PMID: 24906154, PMCID: PMC4144415, PII: S0092-8674(14)00598-4, DOI: 10.1016/j.cell.2014.05.009, ISSN: 1097-4172.

Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E. The way Wnt works: components and mechanism. Growth Factors [print-electronic]. 2013 Feb; 31(1): 1-31. PMID: 23256519, PMCID: PMC3697919, DOI: 10.3109/08977194.2012.752737, ISSN: 1029-2292.

Stevens LJ, Page-McCaw A. A secreted MMP is required for reepithelialization during wound healing. Mol. Biol. Cell [print-electronic]. 2012 Mar; 23(6): 1068-79. PMID: 22262460, PMCID: PMC3302734, PII: mbc.E11-09-0745, DOI: 10.1091/mbc.E11-09-0745, ISSN: 1939-4586.

Broderick S, Wang X, Simms N, Page-McCaw A. Drosophila Ninjurin A induces nonapoptotic cell death. PLoS ONE [print-electronic]. 2012; 7(9): e44567. PMID: 23028562, PMCID: PMC3460944, PII: PONE-D-12-13545, DOI: 10.1371/journal.pone.0044567, ISSN: 1932-6203.

Miller CM, Liu N, Page-McCaw A, Broihier HT. Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila. J. Neurosci. 2011 Apr 4/6/2011; 31(14): 5335-47. PMID: 21471368, PMCID: PMC3486643, PII: 31/14/5335, DOI: 10.1523/JNEUROSCI.4811-10.2011, ISSN: 1529-2401.

Glasheen BM, Robbins RM, Piette C, Beitel GJ, Page-McCaw A. A matrix metalloproteinase mediates airway remodeling in Drosophila. Dev. Biol [print-electronic]. 2010 Aug 8/15/2010; 344(2): 772-83. PMID: 20513443, PMCID: PMC2914218, PII: S0012-1606(10)00807-9, DOI: 10.1016/j.ydbio.2010.05.504, ISSN: 1095-564X.

Glasheen BM, Kabra AT, Page-McCaw A. Distinct functions for the catalytic and hemopexin domains of a Drosophila matrix metalloproteinase. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2009 Feb 2/24/2009; 106(8): 2659-64. PMID: 19196956, PMCID: PMC2636737, PII: 0804171106, DOI: 10.1073/pnas.0804171106, ISSN: 1091-6490.

Page-McCaw A. Remodeling the model organism: matrix metalloproteinase functions in invertebrates. Semin. Cell Dev. Biol [print-electronic]. 2008 Feb; 19(1): 14-23. PMID: 17702617, PMCID: PMC2248213, PII: S1084-9521(07)00089-4, DOI: 10.1016/j.semcdb.2007.06.004, ISSN: 1084-9521.

Miller CM, Page-McCaw A, Broihier HT. Matrix metalloproteinases promote motor axon fasciculation in the Drosophila embryo. Development [print-electronic]. 2008 Jan; 135(1): 95-109. PMID: 18045838, PII: dev.011072, DOI: 10.1242/dev.011072, ISSN: 0950-1991.

Beaucher M, Hersperger E, Page-McCaw A, Shearn A. Metastatic ability of Drosophila tumors depends on MMP activity. Dev. Biol [print-electronic]. 2007 Mar 3/15/2007; 303(2): 625-34. PMID: 17239363, PII: S0012-1606(06)01401-1, DOI: 10.1016/j.ydbio.2006.12.001, ISSN: 0012-1606.

Page-McCaw A, Ewald AJ, Werb Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat. Rev. Mol. Cell Biol. 2007 Mar; 8(3): 221-33. PMID: 17318226, PMCID: PMC2760082, PII: nrm2125, DOI: 10.1038/nrm2125, ISSN: 1471-0072.

Zhang S, Dailey GM, Kwan E, Glasheen BM, Sroga GE, Page-McCaw A. An MMP liberates the Ninjurin A ectodomain to signal a loss of cell adhesion. Genes Dev [print-electronic]. 2006 Jul 7/15/2006; 20(14): 1899-910. PMID: 16815999, PMCID: PMC1522090, PII: gad.1426906, DOI: 10.1101/gad.1426906, ISSN: 0890-9369.

Myllykangas L, Tyynelä J, Page-McCaw A, Rubin GM, Haltia MJ, Feany MB. Cathepsin D-deficient Drosophila recapitulate the key features of neuronal ceroid lipofuscinoses. Neurobiol. Dis. 2005 Jun; 19(1-2): 194-9. PMID: 15837574, PII: S0969-9961(04)00324-9, DOI: 10.1016/j.nbd.2004.12.019, ISSN: 0969-9961.

Page-McCaw A, Serano J, Santé JM, Rubin GM. Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development. Dev. Cell. 2003 Jan; 4(1): 95-106. PMID: 12530966, PII: S1534580702004008, ISSN: 1534-5807.