Chanjuan Shi, M.D., Ph.D.

Associate Professor

chanjuan.shi@vanderbilt.edu
Faculty Appointments
Associate Professor of Pathology, Microbiology and Immunology
Education
Ph.D., Dalhousie University, Halifax, CanadaM.D., Zhejiang University, Hangzhou, China
Office Address
Vanderbilt University School of Medicine
Pathology, Microbiology, and Immunology - 3rd Fl C3321 MCN
1161 21st Avenue South
Nashville, TN 37232-2561
Publications
Ellison TA, Wolfgang CL, Shi C, Cameron JL, Murakami P, Mun LJ, Singhi AD, Cornish TC, Olino K, Meriden Z, Choti M, Diaz LA, Pawlik TM, Schulick RD, Hruban RH, Edil BH. A single institution's 26-year experience with nonfunctional pancreatic neuroendocrine tumors: a validation of current staging systems and a new prognostic nomogram. Ann. Surg. 2014 Feb; 259(2): 204-12. PMID: 23673766, PMCID: PMC4048026, DOI: 10.1097/SLA.0b013e31828f3174, ISSN: 1528-1140.

Ayers K, Shi C, Washington K, Yachimski P. Expert pathology review and endoscopic mucosal resection alters the diagnosis of patients referred to undergo therapy for Barrett's esophagus. Surg Endosc [print-electronic]. 2013 Aug; 27(8): 2836-40. PMID: 23389078, DOI: 10.1007/s00464-013-2830-x, ISSN: 1432-2218.

O'Neal RL, Nam KT, LaFleur BJ, Barlow B, Nozaki K, Lee HJ, Kim WH, Yang HK, Shi C, Maitra A, Montgomery E, Washington MK, El Rifai W, Drapkin RI, Goldenring JR. Human epididymis protein 4 is up-regulated in gastric and pancreatic adenocarcinomas. Hum. Pathol [print-electronic]. 2013 May; 44(5): 734-42. PMID: 23084584, PMCID: PMC3556378, PII: S0046-8177(12)00275-4, DOI: 10.1016/j.humpath.2012.07.017, ISSN: 1532-8392.

Kawamoto S, Johnson PT, Shi C, Singhi AD, Hruban RH, Wolfgang CL, Edil BH, Fishman EK. Pancreatic neuroendocrine tumor with cystlike changes: evaluation with MDCT. AJR Am J Roentgenol. 2013 Mar; 200(3): W283-90. PMID: 23436873, PMCID: PMC4048027, PII: 200/3/W283, DOI: 10.2214/AJR.12.8941, ISSN: 1546-3141.

Singhi AD, Chu LC, Tatsas AD, Shi C, Ellison TA, Fishman EK, Kawamoto S, Schulick RD, Wolfgang CL, Hruban RH, Edil BH. Cystic pancreatic neuroendocrine tumors: a clinicopathologic study. Am. J. Surg. Pathol. 2012 Nov; 36(11): 1666-73. PMID: 23073325, PII: 00000478-201211000-00009, DOI: 10.1097/PAS.0b013e31826a0048, ISSN: 1532-0979.

Wentz SC, Zhao ZG, Shyr Y, Shi CJ, Merchant NB, Washington K, Xia F, Chakravarthy AB. Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma. World J Gastrointest Oncol. 2012 Oct 10/15/2012; 4(10): 207-15. PMID: 23444312, PMCID: PMC3581835, DOI: 10.4251/wjgo.v4.i10.207, ISSN: 1948-5204.

Deery S, Yates R, Hata J, Shi C, Parikh AA. Gastric adenocarcinoma associated with gastritis cystica profunda in an unoperated stomach. Am Surg. 2012 Aug; 78(8): E379-80. PMID: 22856484, ISSN: 1555-9823.

McCall CM, Shi C, Klein AP, Konukiewitz B, Edil BH, Ellison TA, Wolfgang CL, Schulick RD, Klöppel G, Hruban RH. Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement. Hum. Pathol [print-electronic]. 2012 Aug; 43(8): 1169-76. PMID: 22221702, PMCID: PMC3323730, PII: S0046-8177(11)00405-9, DOI: 10.1016/j.humpath.2011.09.014, ISSN: 1532-8392.

Shi C, Washington K. Molecular testing in colorectal cancer: diagnosis of Lynch syndrome and personalized cancer medicine. Am. J. Clin. Pathol. 2012 Jun; 137(6): 847-59. PMID: 22586043, PII: 137/6/847, DOI: 10.1309/AJCPI83DINULUJNI, ISSN: 1943-7722.

Yachida S, Vakiani E, White CM, Zhong Y, Saunders T, Morgan R, de Wilde RF, Maitra A, Hicks J, Demarzo AM, Shi C, Sharma R, Laheru D, Edil BH, Wolfgang CL, Schulick RD, Hruban RH, Tang LH, Klimstra DS, Iacobuzio-Donahue CA. Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors. Am. J. Surg. Pathol. 2012 Feb; 36(2): 173-84. PMID: 22251937, PMCID: PMC3261427, PII: 00000478-201202000-00002, DOI: 10.1097/PAS.0b013e3182417d36, ISSN: 1532-0979.

Shi C, Hruban RH. Intraductal papillary mucinous neoplasm. Hum. Pathol [print-electronic]. 2012 Jan; 43(1): 1-16. PMID: 21777948, PII: S0046-8177(11)00157-2, DOI: 10.1016/j.humpath.2011.04.003, ISSN: 1532-8392.

Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, Schulick RD, Tang LH, Wolfgang CL, Choti MA, Velculescu VE, Diaz LA, Vogelstein B, Kinzler KW, Hruban RH, Papadopoulos N. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science [print-electronic]. 2011 Mar 3/4/2011; 331(6021): 1199-203. PMID: 21252315, PMCID: PMC3144496, PII: science.1200609, DOI: 10.1126/science.1200609, ISSN: 1095-9203.

Xiong W, Shi C. Images in clinical medicine. Malignant pericardial effusion. N. Engl. J. Med. 2011 Mar 3/3/2011; 364(9): e18. PMID: 21366469, DOI: 10.1056/NEJMicm1009066, ISSN: 1533-4406.

Hong SM, Heaphy CM, Shi C, Eo SH, Cho H, Meeker AK, Eshleman JR, Hruban RH, Goggins M. Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias. Mod. Pathol [print-electronic]. 2011 Feb; 24(2): 256-66. PMID: 20871595, PMCID: PMC3166222, PII: modpathol2010181, DOI: 10.1038/modpathol.2010.181, ISSN: 1530-0285.

Kern SE, Shi C, Hruban RH. The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting. J. Pathol [print-electronic]. 2011 Jan; 223(2): 295-306. PMID: 21125682, PMCID: PMC3767138, DOI: 10.1002/path.2813, ISSN: 1096-9896.

Heaphy CM, de Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, Bettegowda C, Rodriguez FJ, Eberhart CG, Hebbar S, Offerhaus GJ, McLendon R, Rasheed BA, He Y, Yan H, Bigner DD, Oba-Shinjo SM, Marie SK, Riggins GJ, Kinzler KW, Vogelstein B, Hruban RH, Maitra A, Papadopoulos N, Meeker AK. Altered telomeres in tumors with ATRX and DAXX mutations. Science. 2011; 333((6041 Epub)): 425.

Meriden Z, Shi C, Edil BH, Ellison T, Wolfgang CL, Cornish TC, Schulick RD, Hruban RH.. Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis. Am J Surg Pathol. 2011; 35((7)): 981-8.

Kawamoto S, Shi C, Hruban RH, Choti MA, Schulick RD, Fishman EK, Siegelman SS. Small serotonin-producing neuroendocrine tumor of the pancreas associated with pancreatic duct obstruction. AJR Am J Roentgenol. 2011; 197((3)).

Park JY, Cornish TC, Lam-Himlin D, Shi C, Montgomery E. Gastric lesions in patients with autoimmune metaplastic atrophic gastritis (AMAG) in a tertiary care setting. Am. J. Surg. Pathol. 2010 Nov; 34(11): 1591-8. PMID: 20975338, PII: 00000478-201011000-00004, DOI: 10.1097/PAS.0b013e3181f623af, ISSN: 1532-0979.

Lam-Himlin D, Park JY, Cornish TC, Shi C, Montgomery E. Morphologic characterization of syndromic gastric polyps. Am. J. Surg. Pathol. 2010 Nov; 34(11): 1656-62. PMID: 20924281, DOI: 10.1097/PAS.0b013e3181f2b1f1, ISSN: 1532-0979.

Gold DV, Goggins M, Modrak DE, Newsome G, Liu M, Shi C, Hruban RH, Goldenberg DM. Detection of early-stage pancreatic adenocarcinoma. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2010 Nov; 19(11): 2786-94. PMID: 20810605, PMCID: PMC2976815, PII: 1055-9965.EPI-10-0667, DOI: 10.1158/1055-9965.EPI-10-0667, ISSN: 1538-7755.

Shi C, Siegelman SS, Kawamoto S, Wolfgang CL, Schulick RD, Maitra A, Hruban RH. Pancreatic duct stenosis secondary to small endocrine neoplasms: a manifestation of serotonin production?. Radiology [print-electronic]. 2010 Oct; 257(1): 107-14. PMID: 20713615, PMCID: PMC2941724, PII: radiol.10100046, DOI: 10.1148/radiol.10100046, ISSN: 1527-1315.

Shi C, Scudiere JR, Cornish TC, Lam-Himlin D, Park JY, Fox MR, Montgomery EA. Clear cell change in colonic tubular adenoma and corresponding colonic clear cell adenocarcinoma is associated with an altered mucin core protein profile. Am. J. Surg. Pathol. 2010 Sep; 34(9): 1344-50. PMID: 20697252, DOI: 10.1097/PAS.0b013e3181ec0810, ISSN: 1532-0979.

Xiong W, Shi C. Images in cardiovascular medicine: Concomitant persistent left superior vena cava and agenesis of right superior vena cava: a rare congenital anomaly. Circulation. 2010 Jun 6/1/2010; 121(21): 2329-30. PMID: 20516388, PII: 121/21/2329, DOI: 10.1161/CIRCULATIONAHA.109.917336, ISSN: 1524-4539.

Kamiyama H, Kamiyama M, Hong SM, Karikari CA, Lin MT, Borges MW, Griffith M, Young A, Norris-Kirby A, Lubek C, Mizuma M, Feldmann G, Shi C, Liang H, Goggins MG, Maitra A, Hruban RH, Eshleman JR. In vivo and in vitro propagation of intraductal papillary mucinous neoplasms. Lab. Invest [print-electronic]. 2010 May; 90(5): 665-73. PMID: 20231822, PMCID: PMC2885280, PII: labinvest201051, DOI: 10.1038/labinvest.2010.51, ISSN: 1530-0307.

Scudiere JR, Shi C, Hruban RH, Herman JM, Fishman EK, Schulick RD, Wolfgang CL, Makary MA, Thornton K, Montgomery E, Horton KM. Sclerosing mesenteritis involving the pancreas: a mimicker of pancreatic cancer. Am. J. Surg. Pathol. 2010 Apr; 34(4): 447-53. PMID: 20351487, PMCID: PMC2861335, PII: 00000478-201004000-00001, DOI: 10.1097/PAS.0b013e3181d325c0, ISSN: 1532-0979.

Shi C, Klein AP, Goggins M, Maitra A, Canto M, Ali S, Schulick R, Palmisano E, Hruban RH. Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients. Clin. Cancer Res [print-electronic]. 2009 Dec 12/15/2009; 15(24): 7737-43. PMID: 19996207, PMCID: PMC2795080, PII: 1078-0432.CCR-09-0004, DOI: 10.1158/1078-0432.CCR-09-0004, ISSN: 1078-0432.

Koorstra JB, Hong SM, Shi C, Meeker AK, Ryu JK, Offerhaus GJ, Goggins MG, Hruban RH, Maitra A. Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. Mod. Pathol [print-electronic]. 2009 Nov; 22(11): 1439-45. PMID: 19668150, PMCID: PMC2784029, PII: modpathol2009114, DOI: 10.1038/modpathol.2009.114, ISSN: 1530-0285.

Shi C, Chandrasekaran A, Thuluvath PJ, Karikari C, Argani P, Goggins M, Maitra A, Eshleman JR. Ultrasensitive detection of KRAS2 mutations in bile and serum from patients with biliary tract carcinoma using LigAmp technology. J Mol Diagn [print-electronic]. 2009 Nov; 11(6): 583-9. PMID: 19815696, PMCID: PMC2765758, PII: S1525-1578(10)60282-6, DOI: 10.2353/jmoldx.2009.090061, ISSN: 1943-7811.

Taube JM, Begum S, Shi C, Eshleman JR, Westra WH. Benign nodal nevi frequently harbor the activating V600E BRAF mutation. Am. J. Surg. Pathol. 2009 Apr; 33(4): 568-71. PMID: 19033861, DOI: 10.1097/PAS.0b013e31818a64fb, ISSN: 1532-0979.

Shi C, Hruban RH, Klein AP. Familial pancreatic cancer. Arch. Pathol. Lab. Med. 2009 Mar; 133(3): 365-74. PMID: 19260742, PII: 2008-0379-RA, DOI: 10.1043/1543-2165-133.3.365, ISSN: 1543-2165.

Shi C, Hong SM, Lim P, Kamiyama H, Khan M, Anders RA, Goggins M, Hruban RH, Eshleman JR. KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin. Mol. Cancer Res [print-electronic]. 2009 Feb; 7(2): 230-6. PMID: 19208745, PMCID: PMC2708114, PII: 1541-7786.MCR-08-0206, DOI: 10.1158/1541-7786.MCR-08-0206, ISSN: 1541-7786.

Shi C and Argani P. Synchronous primary perianal Paget’s disease and rectal adenocarcinoma: Report of a hitherto unreported phenomenon. Int J of Surg Pathol. 2009; 17((1)): 42-5.

Shi C, Daniels JA, Hruban RH. Molecular characterization of pancreatic neoplasms. Adv Anat Pathol. 2008 Jul; 15(4): 185-95. PMID: 18580095, PII: 00125480-200807000-00001, DOI: 10.1097/PAP.0b013e31817bf57d, ISSN: 1533-4031.

Shi C, Fukushima N, Abe T, Bian Y, Hua L, Wendelburg BJ, Yeo CJ, Hruban RH, Goggins MG, Eshleman JR. Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection. Cancer Biol. Ther. 2008 Mar; 7(3): 353-60. PMID: 18075308, PII: 5362, ISSN: 1555-8576.

Shi C, Parker AR, Hua L, Morrell CN, Lee SC, Bandaru V, Dumler JS, Wu TC, Eshleman JR. Anti-gene padlocks eliminate Escherichia coli based on their genotype. J. Antimicrob. Chemother [print-electronic]. 2008 Feb; 61(2): 262-72. PMID: 18156610, PII: dkm482, DOI: 10.1093/jac/dkm482, ISSN: 1460-2091.

Rogers CD, Fukushima N, Sato N, Shi C, Prasad N, Hustinx SR, Matsubayashi H, Canto M, Eshleman JR, Hruban RH, Goggins M. Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs. Cancer Biol. Ther [print-electronic]. 2006 Oct; 5(10): 1383-9. PMID: 17012836, PII: 3323, ISSN: 1538-4047.

Church JD, Jones D, Flys T, Hoover D, Marlowe N, Chen S, Shi C, Eshleman JR, Guay LA, Jackson JB, Kumwenda N, Taha TE, Eshleman SH. Sensitivity of the ViroSeq HIV-1 genotyping system for detection of the K103N resistance mutation in HIV-1 subtypes A, C, and D. J Mol Diagn. 2006 Sep; 8(4): 430-2; quiz 527. PMID: 16931582, PMCID: PMC1867617, PII: S1525-1578(10)60325-X, DOI: 10.2353/jmoldx.2006.050148, ISSN: 1525-1578.

Bertolesi GE, Walia Da Silva R, Jollimore CA, Shi C, Barnes S, Kelly ME. Ca(v)3.1 splice variant expression during neuronal differentiation of Y-79 retinoblastoma cells. Neuroscience [print-electronic]. 2006 Aug 8/11/2006; 141(1): 259-68. PMID: 16678971, PII: S0306-4522(06)00406-4, DOI: 10.1016/j.neuroscience.2006.03.067, ISSN: 0306-4522.

Rubio-Viqueira B, Jimeno A, Cusatis G, Zhang X, Iacobuzio-Donahue C, Karikari C, Shi C, Danenberg K, Danenberg PV, Kuramochi H, Tanaka K, Singh S, Salimi-Moosavi H, Bouraoud N, Amador ML, Altiok S, Kulesza P, Yeo C, Messersmith W, Eshleman J, Hruban RH, Maitra A, Hidalgo M. An in vivo platform for translational drug development in pancreatic cancer. Clin. Cancer Res. 2006 Aug 8/1/2006; 12(15): 4652-61. PMID: 16899615, PII: 12/15/4652, DOI: 10.1158/1078-0432.CCR-06-0113, ISSN: 1078-0432.

Parker AR, Sieber OM, Shi C, Hua L, Takao M, Tomlinson IP, Eshleman JR. Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair. Carcinogenesis [print-electronic]. 2005 Nov; 26(11): 2010-8. PMID: 15987719, PII: bgi166, DOI: 10.1093/carcin/bgi166, ISSN: 0143-3334.

Flys T, Nissley DV, Claasen CW, Jones D, Shi C, Guay LA, Musoke P, Mmiro F, Strathern JN, Jackson JB, Eshleman JR, Eshleman SH. Sensitive drug-resistance assays reveal long-term persistence of HIV-1 variants with the K103N nevirapine (NVP) resistance mutation in some women and infants after the administration of single-dose NVP: HIVNET 012. J. Infect. Dis [print-electronic]. 2005 Jul 7/1/2005; 192(1): 24-9. PMID: 15942890, PII: JID34102, DOI: 10.1086/430742, ISSN: 0022-1899.

Vessey JP, Shi C, Jollimore CA, Stevens KT, Coca-Prados M, Barnes S, Kelly ME. Hyposmotic activation of ICl,swell in rabbit nonpigmented ciliary epithelial cells involves increased ClC-3 trafficking to the plasma membrane. Biochem. Cell Biol. 2004 Dec; 82(6): 708-18. PMID: 15674438, PII: o04-107, DOI: 10.1139/o04-107, ISSN: 0829-8211.

Shi C, Eshleman SH, Jones D, Fukushima N, Hua L, Parker AR, Yeo CJ, Hruban RH, Goggins MG, Eshleman JR. LigAmp for sensitive detection of single-nucleotide differences. Nat. Methods [print-electronic]. 2004 Nov; 1(2): 141-7. PMID: 15782177, PII: nmeth713, DOI: 10.1038/nmeth713, ISSN: 1548-7091.

Shi C, Szczesniak A, Mao L, Jollimore C, Coca-Prados M, Hung O, Kelly ME. A3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway. Br. J. Pharmacol. 2003 Jun; 139(3): 475-86. PMID: 12788807, PMCID: PMC1573867, DOI: 10.1038/sj.bjp.0705266, ISSN: 0007-1188.

Bertolesi GE, Jollimore CA, Shi C, Elbaum L, Denovan-Wright EM, Barnes S, Kelly ME. Regulation of alpha1G T-type calcium channel gene (CACNA1G) expression during neuronal differentiation. Eur. J. Neurosci. 2003 May; 17(9): 1802-10. PMID: 12752779, PII: 2618, ISSN: 0953-816X.

Bertolesi GE, Shi C, Elbaum L, Jollimore C, Rozenberg G, Barnes S, Kelly ME. The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. Mol. Pharmacol. 2002 Aug; 62(2): 210-9. PMID: 12130671, ISSN: 0026-895X.

Thoreson WB, Ryan JS, Shi C, Kelly ME, Bryson EJ, Toews ML, Ediger TL, Chacko DM. Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 2002 Jul; 43(7): 2450-61. PMID: 12091450, ISSN: 0146-0404.

Shi C, Barnes S, Coca-Prados M, Kelly ME. Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line. Invest. Ophthalmol. Vis. Sci. 2002 May; 43(5): 1525-32. PMID: 11980870, ISSN: 0146-0404.

Ryan JS, Shi C, Kelly ME. Patch-clamp recording methods for examining adrenergic regulation of potassium currents in ocular epithelial cells. Methods Mol. Biol. 2000; 126: 391-407. PMID: 10685425, ISSN: 1064-3745.

Shi C, Ryan JS, French AS, Coca-Prados M, Kelly ME. Hyposmotically activated chloride channels in cultured rabbit non-pigmented ciliary epithelial cells. J. Physiol. (Lond.). 1999 Nov 11/15/1999; 521 Pt 1: 57-67. PMID: 10562334, PMCID: PMC2269649, PII: PHY_9451, ISSN: 0022-3751.