Mayur B. Patel, M.D.

Assistant Professor

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Faculty Appointments
Assistant Professor of Surgery Assistant Professor of Neurological SurgeryAssistant Professor of Hearing and Speech Sciences
M.P.H., Public Health , Vanderbilt University, Nashville, TennesseeM.D., Medicine , Vanderbilt University, Nashville, TennesseeB.A., Johns Hopkins University, Baltimore, Maryland
Research Description
Dr. Patel's research focuses on getting answers that matter to trauma victims, ICU survivors, and their health-care providers. His current research interests focus on brain dysfunction and critical illness, as related to ICU delirium, traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), long-term cognitive impairment, and other aspects of ICU survivorship. The National Institutes of Health, Agency for Healthcare Research & Quality, Eastern Association Surgery of Trauma Foundation Research Scholarship, Vanderbilt CTSA, and the Vanderbilt Faculty Scholars Program have supported his research efforts.

Dr. Patel is a member of the ICU Delirium and Cognitive Impairment Study Group:

For more details of his work or for his CV, please contact him.
Clinical Description
Dr. Mayur B. Patel is an Assistant Professor in the Department of Surgery, Division of Trauma & Surgical Critical Care at Vanderbilt University Medical Center and staff surgical intensivist in Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System in Nashville, Tennessee. Dr. Patel graduated Phi Beta Kappa with General and Departmental Honors from Johns Hopkins University and earned his medical degree at Vanderbilt University. He then completed his general surgery residency at Duke University. He returned to Vanderbilt University for his clinical training in surgical critical care, trauma, and acute care surgery, and for his research training by completing Vanderbilt’s two-year program in the Master of Public Health. Dr. Patel has three active Board Certifiicates in General Surgery, Surgical Critical Care, Neurocritical Care.
Research Keywords
Brain Dysfunction, Critical Care, ICU, Intensive Care Unit, Delirium, Traumatic Brain Injury (TBI), Post-Traumatic Stress Disorder (PTSD), Long-Term Cognitive Impairment
Clinical Research Keywords
Surgery, Trauma, Critical Care, Acute Care Surgery, Emergency General Surgery, Neurocritical Care
Humble SS, Wilson LD, Leath TC, Marshall MD, Sun DZ, Pandharipande PP, Patel MB. ICU sedation with dexmedetomidine after severe traumatic brain injury. Brain Inj [print-electronic]. 2016 Jul 7/26/2016; 1-5. PMID: 27458990, DOI: 10.1080/02699052.2016.1187289, ISSN: 1362-301X.

Dennis BM, Vella MA, Gunter OL, Smith MD, Wilson CS, Patel MB, Nunez TC, Guillamondegui OD. Rural Trauma Team Development Course Decreases Time to Transfer for Trauma Patients. J Trauma Acute Care Surg [print-electronic]. 2016 Jul 7/20/2016; PMID: 27438684, DOI: 10.1097/TA.0000000000001188, ISSN: 2163-0763.

Hughes CG, Patel MB, Jackson JC, Girard TD, Geevarghese SK, Norman BC, Thompson JL, Chandrasekhar R, Brummel NE, May AK, Elstad MR, Wasserstein ML, Goodman RB, Moons KG, Dittus RS, Ely EW, Pandharipande PP, . Surgery and Anesthesia Exposure Is Not a Risk Factor for Cognitive Impairment After Major Noncardiac Surgery and Critical Illness. Ann. Surg [print-electronic]. 2016 Jul 7/18/2016; PMID: 27433893, DOI: 10.1097/SLA.0000000000001885, ISSN: 1528-1140.

Chaganti S, Plassard AJ, Wilson L, Smith MA, Patel MB, Landman BA. A Bayesian Framework for Early Risk Prediction in Traumatic Brain Injury. Proc SPIE Int Soc Opt Eng [print-electronic]. 2016 Feb 2/27/2016; 9784: PMID: 27127331, PMCID: PMC4845965, DOI: 10.1117/12.2217306, ISSN: 0277-786X.

Ferrada P, Patel M, Poylin VY, Bruns B, Leichtle S, Wydo S, Sultan S, Haut E, Robinson B. Surgery or stenting for colonic obstruction: a practice management guideline from the eastern association for the surgery of trauma. J Trauma Acute Care Surg [print-electronic]. 2016 Jan 1/21/2016; PMID: 26808035, DOI: 10.1097/TA.0000000000000966, ISSN: 2163-0763.

Patel MB, Jackson JC, Morandi A, Girard TD, Hughes CG, Thompson JL, Kiehl AL, Elstad MR, Wasserstein ML, Goodman RB, Beckham JC, Chandrasekhar R, Dittus RS, Ely EW, Pandharipande PP. Incidence and Risk Factors for ICU-related Posttraumatic Stress Disorder In Veterans and Civilians. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Jan 1/6/2016; PMID: 26735627, DOI: 10.1164/rccm.201506-1158OC, ISSN: 1535-4970.

Patel MB, Wilson LD, Bregman JA, Leath TC, Humble SS, Davidson MA, de Riesthal MR, Guillamondegui OD. Neurologic Functional and Quality of Life Outcomes after TBI: Clinic Attendees versus Non-Attendees. J. Neurotrauma [print-electronic]. 2015 Jul 7/1/2015; 32(13): 984-9. PMID: 25683481, PMCID: PMC4492588, DOI: 10.1089/neu.2014.3652, ISSN: 1557-9042.

Patel MB, Morandi A, Pandharipande PP. What's new in post-ICU cognitive impairment?. Intensive Care Med [print-electronic]. 2015 Apr; 41(4): 708-11. PMID: 25619483, DOI: 10.1007/s00134-014-3632-x, ISSN: 1432-1238.

Plassard AJ, Kelly PD, Asman AJ, Kang H, Patel MB, Landman BA. Revealing Latent Value of Clinically Acquired CTs of Traumatic Brain Injury Through Multi-Atlas Segmentation in a Retrospective Study of 1,003 with External Cross-Validation. Proc SPIE Int Soc Opt Eng. 2015 Mar 3/20/2015; 9413: PMID: 25914504, PMCID: PMC4405676, DOI: 10.1117/12.2081329, ISSN: 0277-786X.

Patel MB, Humble SS, Cullinane DC, Day MA, Jawa RS, Devin CJ, Delozier MS, Smith LM, Smith MA, Capella JM, Long AM, Cheng JS, Leath TC, Falck-Ytter Y, Haut ER, Como JJ. Cervical spine collar clearance in the obtunded adult blunt trauma patient: a systematic review and practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2015 Feb; 78(2): 430-41. PMID: 25757133, PMCID: PMC4409130, PII: 01586154-201502000-00031, DOI: 10.1097/TA.0000000000000503, ISSN: 2163-0763.

Patel MB, Laudanski K, Pandharipande PP. An international career development survey of critical care practitioners*. Crit. Care Med. 2014 Apr; 42(4): e300-3. PMID: 24335441, PMCID: PMC3959251, DOI: 10.1097/CCM.0000000000000137, ISSN: 1530-0293.

Pandharipande PP, Patel MB, Barr J. Management of pain, agitation, and delirium in critically ill patients. Pol. Arch. Med. Wewn [print-electronic]. 2014; 124(3): 114-23. PMID: 24424616, PII: AOP_13_080, ISSN: 1897-9483.

Patel MB, Guillamondegui OD, May AK, Diaz JJ. Twenty-year analysis of surgical resident operative trauma experiences. J. Surg. Res [print-electronic]. 2013 Apr; 180(2): 191-5. PMID: 22632939, PII: S0022-4804(12)00421-0, DOI: 10.1016/j.jss.2012.04.061, ISSN: 1095-8673.

Hughes CG, Patel MB, Pandharipande PP. Pathophysiology of acute brain dysfunction: what's the cause of all this confusion?. Curr Opin Crit Care. 2012 Oct; 18(5): 518-26. PMID: 22941208, DOI: 10.1097/MCC.0b013e328357effa, ISSN: 1531-7072.

Patel MB, Guillamondegui OD, Ott MM, Palmiter KA, May AK. O' surgery case log data, where art thou?. J. Am. Coll. Surg [print-electronic]. 2012 Sep; 215(3): 427-31. PMID: 22634118, PMCID: PMC3423479, PII: S1072-7515(12)00312-2, DOI: 10.1016/j.jamcollsurg.2012.04.017, ISSN: 1879-1190.

Patel MB, High K, Eckert M. Tension pneumoperitoneum after traumatic gastric rupture. Am Surg. 2012 Sep; 78(9): E435-6. PMID: 22964191, ISSN: 1555-9823.

Andersen ND, Bhattacharya SD, Williams JB, Fosbol EL, Lockhart EL, Patel MB, Gaca JG, Welsby IJ, Hughes GC. Intraoperative use of low-dose recombinant activated factor VII during thoracic aortic operations. Ann. Thorac. Surg [print-electronic]. 2012 Jun; 93(6): 1921-8; discussion 1928. PMID: 22551846, PMCID: PMC3718882, PII: S0003-4975(12)00396-7, DOI: 10.1016/j.athoracsur.2012.02.037, ISSN: 1552-6259.

Webb LH, Patel MB, Dortch MJ, Miller RS, Gunter OL, Collier BR. Use of a furosemide drip does not improve earlier primary fascial closure in the open abdomen. J Emerg Trauma Shock. 2012 Apr; 5(2): 126-30. PMID: 22787341, PMCID: PMC3391835, PII: JETS-5-126, DOI: 10.4103/0974-2700.96480, ISSN: 0974-519X.

Patel MB, McKenna JW, Alvarez JM, Sugiura A, Jenkins JM, Guillamondegui OD, Pandharipande PP. Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial. Trials. 2012; 13: 177. PMID: 23013802, PMCID: PMC3517360, PII: 1745-6215-13-177, DOI: 10.1186/1745-6215-13-177, ISSN: 1745-6215.

Coursey CA, Nelson RC, Moreno RD, Patel MB, Beam CA, Vaslef S. Appendicitis, body mass index, and CT: is CT more valuable for obese patients than thin patients?. Am Surg. 2011 Apr; 77(4): 471-5. PMID: 21679558, ISSN: 1555-9823.

Kim CY, Patel MB, Miller MJ, Suhocki PV, Balius A, Smith TP. Gastrostomy-to-gastrojejunostomy tube conversion: impact of the method of original gastrostomy tube placement. J Vasc Interv Radiol [print-electronic]. 2010 Jul; 21(7): 1031-7. PMID: 20538477, PII: S1051-0443(10)00327-1, DOI: 10.1016/j.jvir.2010.04.003, ISSN: 1535-7732.

Coursey CA, Nelson RC, Moreno RD, Dodd LG, Patel MB, Vaslef S. Carcinoid tumors of the appendix: are these tumors identifiable prospectively on preoperative CT?. Am Surg. 2010 Mar; 76(3): 273-5. PMID: 20349655, ISSN: 0003-1348.

Coursey CA, Nelson RC, Patel MB, Cochran C, Dodd LG, Delong DM, Beam CA, Vaslef S. Making the diagnosis of acute appendicitis: do more preoperative CT scans mean fewer negative appendectomies? A 10-year study. Radiology. 2010 Feb; 254(2): 460-8. PMID: 20093517, PII: 254/2/460, DOI: 10.1148/radiol.09082298, ISSN: 1527-1315.

Geng Q, Romero J, Saini V, Patel MB, Majetschak M. Extracellular 20S proteasomes accumulate in packed red blood cell units [letter]. Vox Sang. 2009 Oct; 97(3): 273-4. PMID: 19790296, ISSN: 1423-0410.

Garrigues GE, Patel MB, Colletti TP, Weaver JP, Mallon WJ. Thrombosis of the brachial artery after closed dislocation of the elbow. J Bone Joint Surg Br. 2009 Aug; 91(8): 1097-9. PMID: 19651843, PII: 91-B/8/1097, DOI: 10.1302/0301-620X.91B8.21882, ISSN: 0301-620X.

Manning EW, Patel MB, Garcia-Covarrubias L, Rahnemai-Azar AA, Pham SM, Majetschak M. Proteasome peptidase activities parallel histomorphological and functional consequences of ischemia-reperfusion injury in the lung. Exp. Lung Res. 2009 May; 35(4): 284-95. PMID: 19415546, PII: 910943342, DOI: 10.1080/01902140802668823, ISSN: 1521-0499.

Funk DJ, Lujan E, Moretti EW, Davies J, Young CC, Patel MB, Vaslef SN. A brief report: the use of high-frequency oscillatory ventilation for severe pulmonary contusion. J Trauma. 2008 Aug; 65(2): 390-5. PMID: 18695477, PII: 00005373-200808000-00020, DOI: 10.1097/TA.0b013e31817f283f, ISSN: 1529-8809.

Majetschak M, Zedler S, Hostmann A, Sorell LT, Patel MB, Novar LT, Kraft R, Habib F, de Moya MA, Ertel W, Faist E, Schade U. Systemic ubiquitin release after blunt trauma and burns: association with injury severity, posttraumatic complications, and survival. J Trauma. 2008 Mar; 64(3): 586-96; discussion 596. PMID: 18332797, PII: 00005373-200803000-00004, DOI: 10.1097/TA.0b013e3181641bc5, ISSN: 1529-8809.

Majetschak M, Patel MB, Sorell LT, Liotta C, Li S, Pham SM. Cardiac proteasome dysfunction during cold ischemic storage and reperfusion in a murine heart transplantation model. Biochem. Biophys. Res. Commun [print-electronic]. 2008 Jan 1/25/2008; 365(4): 882-8. PMID: 18053796, PII: S0006-291X(07)02522-3, DOI: 10.1016/j.bbrc.2007.11.092, ISSN: 1090-2104.

Patel MB, Earle SA, Majetschak M. Dynamics of tissue ubiquitin pools and ubiquitin-proteasome pathway component activities during the systemic response to traumatic shock. Physiol Res [print-electronic]. 2007; 56(5): 547-57. PMID: 17184142, PII: 1068, ISSN: 0862-8408.

Patel MB, Majetschak M. Distribution and interrelationship of ubiquitin proteasome pathway component activities and ubiquitin pools in various porcine tissues. Physiol Res [print-electronic]. 2007; 56(3): 341-50. PMID: 16792465, PII: 1005, ISSN: 0862-8408.

Patel MB, Nathan JD, Frush DP, Rice HE. Nonoperative management of asymptomatic traumatic pulmonary hernia in a young child. J Trauma. 2007 Jan; 62(1): 234-5. PMID: 17215762, PII: 00005373-200701000-00036, DOI: 10.1097/01.ta.0000246947.19359.3e, ISSN: 0022-5282.

Earle SA, El-Haddad A, Patel MB, Ruiz P, Pham SM, Majetschak M. Prolongation of skin graft survival by exogenous ubiquitin. Transplantation. 2006 Dec 12/15/2006; 82(11): 1544-6. PMID: 17164731, PII: 00007890-200612150-00029, DOI: 10.1097/, ISSN: 0041-1337.

King DR, Patel MB, Feinstein AJ, Earle SA, Topp RF, Proctor KG. Simulation training for a mass casualty incident: two-year experience at the Army Trauma Training Center. J Trauma. 2006 Oct; 61(4): 943-8. PMID: 17033566, PII: 00005373-200610000-00028, DOI: 10.1097/01.ta.0000233670.97515.3a, ISSN: 0022-5282.

Patel MB, Proctor KG, Majetschak M. Extracellular ubiquitin increases in packed red blood cell units during storage. J. Surg. Res [print-electronic]. 2006 Oct; 135(2): 226-32. PMID: 16926027, PII: S0022-4804(06)00218-6, DOI: 10.1016/j.jss.2006.04.037, ISSN: 0022-4804.

Patel MB, Feinstein AJ, Saenz AD, Majetschak M, Proctor KG. Prehospital HBOC-201 after traumatic brain injury and hemorrhagic shock in swine. J Trauma. 2006 Jul; 61(1): 46-56. PMID: 16832248, PII: 00005373-200607000-00006, DOI: 10.1097/01.ta.0000219730.71206.3a, ISSN: 0022-5282.

Feinstein AJ, Patel MB, Sanui M, Cohn SM, Majetschak M, Proctor KG. Resuscitation with pressors after traumatic brain injury. J. Am. Coll. Surg. 2005 Oct; 201(4): 536-45. PMID: 16183491, PII: S1072-7515(05)00663-0, DOI: 10.1016/j.jamcollsurg.2005.05.031, ISSN: 1072-7515.

Earle SA, Proctor KG, Patel MB, Majetschak M. Ubiquitin reduces fluid shifts after traumatic brain injury. Surgery. 2005 Sep; 138(3): 431-8. PMID: 16213895, PII: S0039-6060(05)00361-2, DOI: 10.1016/j.surg.2005.06.026, ISSN: 0039-6060.

Burleigh ME, Babaev VR, Patel MB, Crews BC, Remmel RP, Morrow JD, Oates JA, Marnett LJ, Fazio S, Linton MF. Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice. Biochem. Pharmacol. 2005 Aug 8/1/2005; 70(3): 334-42. PMID: 15950196, PII: S0006-2952(05)00285-6, DOI: 10.1016/j.bcp.2005.04.044, ISSN: 0006-2952.

Babaev VR, Patel MB, Semenkovich CF, Fazio S, Linton MF. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice. J. Biol. Chem. 2000 Aug 8/25/2000; 275(34): 26293-9. PMID: 10858435, PII: M002423200, DOI: 10.1074/jbc.M002423200, ISSN: 0021-9258.

Segal BH, Sakamoto N, Patel M, Maemura K, Klein AS, Holland SM, Bulkley GB. Xanthine oxidase contributes to host defense against Burkholderia cepacia in the p47(phox-/-) mouse model of chronic granulomatous disease. Infect. Immun. 2000 Apr; 68(4): 2374-8. PMID: 10722648, PMCID: PMC97432, ISSN: 0019-9567.

Yamakawa Y, Takano M, Patel M, Tien N, Takada T, Bulkley GB. Interaction of platelet activating factor, reactive oxygen species generated by xanthine oxidase, and leukocytes in the generation of hepatic injury after shock/resuscitation. Ann. Surg. 2000 Mar; 231(3): 387-98. PMID: 10714632, PMCID: PMC1421010, ISSN: 0003-4932.

Wilkins KB, Sheikh E, Green R, Patel M, George S, Takano M, Diener-West M, Welsh J, Howard S, Askin F, Bulkley GB. Clinical and pathologic predictors of survival in patients with thymoma. Ann. Surg. 1999 Oct; 230(4): 562-72; discussion 572. PMID: 10522726, PMCID: PMC1420905, ISSN: 0003-4932.