Milam A. Brantley, Jr., Ph.D., M.D.

Associate Professor

milam.brantley@vanderbilt.edu

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Faculty Appointments
Associate Professor of Ophthalmology and Visual Sciences Associate Professor of Molecular Physiology and Biophysics
Education
M.D., M.D., NOT APPLICABLE, Baylor College of Medicine, Houston, TexasPh.D., MOLECULAR AND HUMAN GENETICS, Baylor University, Waco, TexasB.A., Austin College, Sherman, Texas
Research Keywords
Pharmacogenomics and metabolomics of retinal diseases
Clinical Research Keywords
Inherited retinal diseases, genetics of age-related macular degeneration and diabetic retinopathy, ocular pharmacogenomics, metabolomics of retinal diseases
Publications
Hoffman JD, van Grinsven MJ, Li C, Brantley M, McGrath J, Agarwal A, Scott WK, Schwartz SG, Kovach J, Pericak-Vance M, Sanchez CI, Haines JL. Genetic Association Analysis of Drusen Progression. Invest. Ophthalmol. Vis. Sci. 2016 Apr 4/1/2016; 57(4): 2225-31. PMID: 27116550, PMCID: PMC4849854, PII: 2518412, DOI: 10.1167/iovs.15-18571, ISSN: 1552-5783.

Kovach JL, Schwartz SG, Agarwal A, Brantley MA, Pan SS, Haines JL, Scott WK, Pericak-Vance MA. The Relationship Between Reticular Pseudodrusen and Severity of AMD. Ophthalmology [print-electronic]. 2016 Apr; 123(4): 921-3. PMID: 26681389, PMCID: PMC4808363, PII: S0161-6420(15)01258-0, DOI: 10.1016/j.ophtha.2015.10.036, ISSN: 1549-4713.

Fritsche LG, Igl W, Bailey JN, Grassmann F, Sengupta S, Bragg-Gresham JL, Burdon KP, Hebbring SJ, Wen C, Gorski M, Kim IK, Cho D, Zack D, Souied E, Scholl HP, Bala E, Lee KE, Hunter DJ, Sardell RJ, Mitchell P, Merriam JE, Cipriani V, Hoffman JD, Schick T, Lechanteur YT, Guymer RH, Johnson MP, Jiang Y, Stanton CM, Buitendijk GH, Zhan X, Kwong AM, Boleda A, Brooks M, Gieser L, Ratnapriya R, Branham KE, Foerster JR, Heckenlively JR, Othman MI, Vote BJ, Liang HH, Souzeau E, McAllister IL, Isaacs T, Hall J, Lake S, Mackey DA, Constable IJ, Craig JE, Kitchner TE, Yang Z, Su Z, Luo H, Chen D, Ouyang H, Flagg K, Lin D, Mao G, Ferreyra H, Stark K, von Strachwitz CN, Wolf A, Brandl C, Rudolph G, Olden M, Morrison MA, Morgan DJ, Schu M, Ahn J, Silvestri G, Tsironi EE, Park KH, Farrer LA, Orlin A, Brucker A, Li M, Curcio CA, Mohand-Saïd S, Sahel JA, Audo I, Benchaboune M, Cree AJ, Rennie CA, Goverdhan SV, Grunin M, Hagbi-Levi S, Campochiaro P, Katsanis N, Holz FG, Blond F, Blanché H, Deleuze JF, Igo RP, Truitt B, Peachey NS, Meuer SM, Myers CE, Moore EL, Klein R, Hauser MA, Postel EA, Courtenay MD, Schwartz SG, Kovach JL, Scott WK, Liew G, Tan AG, Gopinath B, Merriam JC, Smith RT, Khan JC, Shahid H, Moore AT, McGrath JA, Laux R, Brantley MA, Agarwal A, Ersoy L, Caramoy A, Langmann T, Saksens NT, de Jong EK, Hoyng CB, Cain MS, Richardson AJ, Martin TM, Blangero J, Weeks DE, Dhillon B, van Duijn CM, Doheny KF, Romm J, Klaver CC, Hayward C, Gorin MB, Klein ML, Baird PN, den Hollander AI, Fauser S, Yates JR, Allikmets R, Wang JJ, Schaumberg DA, Klein BE, Hagstrom SA, Chowers I, Lotery AJ, Léveillard T, Zhang K, Brilliant MH, Hewitt AW, Swaroop A, Chew EY, Pericak-Vance MA, DeAngelis M, Stambolian D, Haines JL, Iyengar SK, Weber BH, Abecasis GR, Heid IM. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat. Genet [print-electronic]. 2016 Feb; 48(2): 134-43. PMID: 26691988, PMCID: PMC4745342, PII: ng.3448, DOI: 10.1038/ng.3448, ISSN: 1546-1718.

Schwartz SG, Hampton BM, Kovach JL, Brantley MA. Genetics and age-related macular degeneration: a practical review for the clinician. Clin Ophthalmol. 2016; 10: 1229-35. PMID: 27445455, PMCID: PMC4938141, PII: opth-10-1229, DOI: 10.2147/OPTH.S109723, ISSN: 1177-5467.

Umfress AC, Brantley MA. Eye Care Disparities and Health-Related Consequences in Elderly Patients with Age-Related Eye Disease. Semin Ophthalmol [print-electronic]. 2016; 31(4): 432-8. PMID: 27116323, PMCID: PMC4990069, DOI: 10.3109/08820538.2016.1154171, ISSN: 1744-5205.

Burgess LG, Uppal K, Walker DI, Roberson RM, Tran V, Parks MB, Wade EA, May AT, Umfress AC, Jarrell KL, Stanley BO, Kuchtey J, Kuchtey RW, Jones DP, Brantley MA. Metabolome-Wide Association Study of Primary Open Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2015 Jul; 56(8): 5020-8. PMID: 26230767, PMCID: PMC4525636, PII: 2422884, DOI: 10.1167/iovs.15-16702, ISSN: 1552-5783.

Hampton BM, Schwartz SG, Brantley MA, Flynn HW. Update on genetics and diabetic retinopathy. Clin Ophthalmol. 2015; 9: 2175-93. PMID: 26648684, PMCID: PMC4664538, PII: opth-9-2175, DOI: 10.2147/OPTH.S94508, ISSN: 1177-5467.

Hall JB, Cooke Bailey JN, Hoffman JD, Pericak-Vance MA, Scott WK, Kovach JL, Schwartz SG, Agarwal A, Brantley MA, Haines JL, Bush WS. Estimating cumulative pathway effects on risk for age-related macular degeneration using mixed linear models. BMC Bioinformatics. 2015; 16: 329. PMID: 26467978, PMCID: PMC4606903, PII: 10.1186/s12859-015-0760-4, DOI: 10.1186/s12859-015-0760-4, ISSN: 1471-2105.

Estopinal CB, Chocron IM, Parks MB, Wade EA, Roberson RM, Burgess LG, Brantley MA, Samuels DC. Mitochondrial haplogroups are associated with severity of diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2014 Sep; 55(9): 5589-95. PMID: 25118268, PMCID: PMC4160073, PII: iovs.14-15149, DOI: 10.1167/iovs.14-15149, ISSN: 1552-5783.

Kuchtey J, Kunkel J, Burgess LG, Parks MB, Brantley MA, Kuchtey RW. Elevated transforming growth factor ß1 in plasma of primary open-angle glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2014 Aug; 55(8): 5291-7. PMID: 25061114, PMCID: PMC4142830, PII: iovs.14-14578, DOI: 10.1167/iovs.14-14578, ISSN: 1552-5783.

Osborn MP, Park Y, Parks MB, Burgess LG, Uppal K, Lee K, Jones DP, Brantley MA. Metabolome-wide association study of neovascular age-related macular degeneration. PLoS ONE. 2013; 8(8): e72737. PMID: 24015273, PMCID: PMC3754980, PII: PONE-D-13-06396, DOI: 10.1371/journal.pone.0072737, ISSN: 1932-6203.

Brantley MA, Osborn MP, Sanders BJ, Rezaei KA, Lu P, Li C, Milne GL, Cai J, Sternberg P. The short-term effects of antioxidant and zinc supplements on oxidative stress biomarker levels in plasma: a pilot investigation. Am. J. Ophthalmol [print-electronic]. 2012 Jun; 153(6): 1104-9.e2. PMID: 22381365, PMCID: PMC3358482, PII: S0002-9394(11)00990-1, DOI: 10.1016/j.ajo.2011.12.010, ISSN: 1879-1891.

Brantley MA, Osborn MP, Sanders BJ, Rezaei KA, Lu P, Li C, Milne GL, Cai J, Sternberg P. Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration. Am. J. Ophthalmol [print-electronic]. 2012 Mar; 153(3): 460-467.e1. PMID: 22035603, PMCID: PMC3288635, PII: S0002-9394(11)00675-1, DOI: 10.1016/j.ajo.2011.08.033, ISSN: 1879-1891.

Yu Y, Bhangale TR, Fagerness J, Ripke S, Thorleifsson G, Tan PL, Souied EH, Richardson AJ, Merriam JE, Buitendijk GH, Reynolds R, Raychaudhuri S, Chin KA, Sobrin L, Evangelou E, Lee PH, Lee AY, Leveziel N, Zack DJ, Campochiaro B, Campochiaro P, Smith RT, Barile GR, Guymer RH, Hogg R, Chakravarthy U, Robman LD, Gustafsson O, Sigurdsson H, Ortmann W, Behrens TW, Stefansson K, Uitterlinden AG, van Duijn CM, Vingerling JR, Klaver CC, Allikmets R, Brantley MA, Baird PN, Katsanis N, Thorsteinsdottir U, Ioannidis JP, Daly MJ, Graham RR, Seddon JM. Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum. Mol. Genet [print-electronic]. 2011 Sep 9/15/2011; 20(18): 3699-709. PMID: 21665990, PMCID: PMC3159552, PII: ddr270, DOI: 10.1093/hmg/ddr270, ISSN: 1460-2083.

Sheybani A, Brantley MA, Apte RS. Pattern electroretinography in age-related macular degeneration. Arch. Ophthalmol. 2011 May; 129(5): 580-4. PMID: 21555610, PII: 129/5/580, DOI: 10.1001/archophthalmol.2011.83, ISSN: 1538-3601.

Lee AY, Kulkarni M, Fang AM, Edelstein S, Osborn MP, Brantley MA. The effect of genetic variants in SERPING1 on the risk of neovascular age-related macular degeneration. Br J Ophthalmol. 2010 Jul; 94(7): 915-7. PMID: 20606025, PMCID: PMC3655725, PII: 94/7/915, DOI: 10.1136/bjo.2009.172007, ISSN: 1468-2079.

Neale BM, Fagerness J, Reynolds R, Sobrin L, Parker M, Raychaudhuri S, Tan PL, Oh EC, Merriam JE, Souied E, Bernstein PS, Li B, Frederick JM, Zhang K, Brantley MA, Lee AY, Zack DJ, Campochiaro B, Campochiaro P, Ripke S, Smith RT, Barile GR, Katsanis N, Allikmets R, Daly MJ, Seddon JM. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2010 Apr 4/20/2010; 107(16): 7395-400. PMID: 20385826, PMCID: PMC2867697, PII: 0912019107, DOI: 10.1073/pnas.0912019107, ISSN: 1091-6490.

Hegedus B, Hughes FW, Garbow JR, Gianino S, Banerjee D, Kim K, Ellisman MH, Brantley MA, Gutmann DH. Optic nerve dysfunction in a mouse model of neurofibromatosis-1 optic glioma. J. Neuropathol. Exp. Neurol. 2009 May; 68(5): 542-51. PMID: 19525901, PMCID: PMC2746323, PII: 00005072-200905000-00010, DOI: 10.1097/NEN.0b013e3181a3240b, ISSN: 0022-3069.

Lee AY, Raya AK, Kymes SM, Shiels A, Brantley MA. Pharmacogenetics of complement factor H (Y402H) and treatment of exudative age-related macular degeneration with ranibizumab. Br J Ophthalmol [print-electronic]. 2009 May; 93(5): 610-3. PMID: 19091853, PMCID: PMC3490485, PII: bjo.2008.150995, DOI: 10.1136/bjo.2008.150995, ISSN: 1468-2079.

Brantley MA, Edelstein SL, King JM, Plotzke MR, Apte RS, Kymes SM, Shiels A. Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to photodynamic therapy. Eye (Lond) [print-electronic]. 2009 Mar; 23(3): 626-31. PMID: 18292785, PII: eye200828, DOI: 10.1038/eye.2008.28, ISSN: 1476-5454.

Fang AM, Lee AY, Kulkarni M, Osborn MP, Brantley MA. Polymorphisms in the VEGFA and VEGFR-2 genes and neovascular age-related macular degeneration. Mol. Vis. 2009; 15: 2710-9. PMID: 20019880, PMCID: PMC2793900, PII: 287, ISSN: 1090-0535.

Lee AY, Brantley MA. CFH and LOC387715/ARMS2 genotypes and antioxidants and zinc therapy for age-related macular degeneration. Pharmacogenomics. 2008 Oct; 9(10): 1547-50. PMID: 18855541, DOI: 10.2217/14622416.9.10.1547, ISSN: 1744-8042.

Brantley MA, Jain S, Barr EE, Johnson EM, Milbrandt J. Neurturin-mediated ret activation is required for retinal function. J. Neurosci. 2008 Apr 4/16/2008; 28(16): 4123-35. PMID: 18417692, PMCID: PMC2704905, PII: 28/16/4123, DOI: 10.1523/JNEUROSCI.0249-08.2008, ISSN: 1529-2401.

Brantley MA, Fang AM, King JM, Tewari A, Kymes SM, Shiels A. Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to intravitreal bevacizumab. Ophthalmology. 2007 Dec; 114(12): 2168-73. PMID: 18054635, PII: S0161-6420(07)01026-3, DOI: 10.1016/j.ophtha.2007.09.008, ISSN: 1549-4713.

Michaelides M, Chen LL, Brantley MA, Andorf JL, Isaak EM, Jenkins SA, Holder GE, Bird AC, Stone EM, Webster AR. ABCA4 mutations and discordant ABCA4 alleles in patients and siblings with bull's-eye maculopathy. Br J Ophthalmol. 2007 Dec; 91(12): 1650-5. PMID: 18024811, PMCID: PMC2095527, PII: 91/12/1650, DOI: 10.1136/bjo.2007.118356, ISSN: 1468-2079.

Brantley MA, Edelstein SL, King JM, Apte RS, Kymes SM, Shiels A. Clinical phenotypes associated with the complement factor H Y402H variant in age-related macular degeneration. Am. J. Ophthalmol [print-electronic]. 2007 Sep; 144(3): 404-8. PMID: 17631852, PMCID: PMC2140051, PII: S0002-9394(07)00484-9, DOI: 10.1016/j.ajo.2007.05.018, ISSN: 0002-9394.

Zhu Y, Zhang Y, Ojwang BA, Brantley MA, Gidday JM. Long-term tolerance to retinal ischemia by repetitive hypoxic preconditioning: role of HIF-1alpha and heme oxygenase-1. Invest. Ophthalmol. Vis. Sci. 2007 Apr; 48(4): 1735-43. PMID: 17389506, PII: 48/4/1735, DOI: 10.1167/iovs.06-1037, ISSN: 0146-0404.

Knopf HL, Carter K, Council MD, Brantley MA. Peripapillary Hemorrhage. Compr Ophthalmol Update. 2007 Jan; 8(1): 53-4. PMID: 17394760, ISSN: 1527-7313.

Feiner L, Barr EE, Shui YB, Holekamp NM, Brantley MA. Safety of intravitreal injection of bevacizumab in rabbit eyes. Retina (Philadelphia, Pa.). 2006 Oct; 26(8): 882-8. PMID: 17031287, PII: 00006982-200610000-00005, DOI: 10.1097/01.iae.0000230717.85319.f5, ISSN: 0275-004X.

Michaelides M, Jenkins SA, Brantley MA, Andrews RM, Waseem N, Luong V, Gregory-Evans K, Bhattacharya SS, Fitzke FW, Webster AR. Maculopathy due to the R345W substitution in fibulin-3: distinct clinical features, disease variability, and extent of retinal dysfunction. Invest. Ophthalmol. Vis. Sci. 2006 Jul; 47(7): 3085-97. PMID: 16799055, PII: 47/7/3085, DOI: 10.1167/iovs.05-1600, ISSN: 0146-0404.

Mantel I, Brantley MA, Bellmann C, Robson AG, Holder GE, Taylor A, Anderson G, Moore AT. Juvenile neuronal ceroid lipofuscinosis (Batten disease) CLN3 mutation (Chrom 16p11.2) with different phenotypes in a sibling pair and low intensity in vivo autofluorescence. Klin Monbl Augenheilkd. 2004 May; 221(5): 427-30. PMID: 15162299, DOI: 10.1055/s-2004-812819, ISSN: 0023-2165.

Harbour JW, Brantley MA, Hollingsworth H, Gordon M. Association between choroidal pigmentation and posterior uveal melanoma in a white population. Br J Ophthalmol. 2004 Jan; 88(1): 39-43. PMID: 14693770, PMCID: PMC1771924, ISSN: 0007-1161.

Harbour JW, Brantley MA, Hollingsworth H, Gordon M. Association between posterior uveal melanoma and iris freckles, iris naevi, and choroidal naevi. Br J Ophthalmol. 2004 Jan; 88(1): 36-8. PMID: 14693769, PMCID: PMC1771959, ISSN: 0007-1161.

Joseph DP, Brantley MA, Grand MG. Serpiginouslike choroiditis in a patient with cardiac sarcoidosis. Retina (Philadelphia, Pa.). 2003 Feb; 23(1): 116-7. PMID: 12652246, ISSN: 0275-004X.

Brantley MA, Worley L, Harbour JW. Altered expression of Rb and p53 in uveal melanomas following plaque radiotherapy. Am. J. Ophthalmol. 2002 Feb; 133(2): 242-8. PMID: 11812429, PII: S0002939401013629, ISSN: 0002-9394.