Milam A. Brantley, Jr., Ph.D., M.D.

Associate Professor

milam.brantley@vanderbilt.edu

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Faculty Appointments
Associate Professor of Ophthalmology and Visual Sciences Associate Professor of Molecular Physiology and BiophysicsAssociate Professor of Molecular Physiology and Biophysics
Education
M.D., M.D., NOT APPLICABLE, Baylor College of Medicine, Houston, TexasPh.D., MOLECULAR AND HUMAN GENETICS, Baylor University, Waco, TexasB.A., Austin College, Sherman, Texas
Research Keywords
Pharmacogenomics and metabolomics of retinal diseases
Clinical Research Keywords
Inherited retinal diseases, genetics of age-related macular degeneration and diabetic retinopathy, ocular pharmacogenomics, metabolomics of retinal diseases
Publications
Burgess LG, Uppal K, Walker DI, Roberson RM, Tran V, Parks MB, Wade EA, May AT, Umfress AC, Jarrell KL, Stanley BO, Kuchtey J, Kuchtey RW, Jones DP, Brantley MA. Metabolome-Wide Association Study of Primary Open Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2015 Jul; 56(8): 5020-8. PMID: 26230767, PMCID: PMC4525636, PII: 2422884, DOI: 10.1167/iovs.15-16702, ISSN: 1552-5783.

Estopinal CB, Chocron IM, Parks MB, Wade EA, Roberson RM, Burgess LG, Brantley MA, Samuels DC. Mitochondrial haplogroups are associated with severity of diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2014 Sep; 55(9): 5589-95. PMID: 25118268, PMCID: PMC4160073, PII: iovs.14-15149, DOI: 10.1167/iovs.14-15149, ISSN: 1552-5783.

Kuchtey J, Kunkel J, Burgess LG, Parks MB, Brantley MA, Kuchtey RW. Elevated transforming growth factor ß1 in plasma of primary open-angle glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2014 Aug; 55(8): 5291-7. PMID: 25061114, PMCID: PMC4142830, PII: iovs.14-14578, DOI: 10.1167/iovs.14-14578, ISSN: 1552-5783.

Osborn MP, Park Y, Parks MB, Burgess LG, Uppal K, Lee K, Jones DP, Brantley MA. Metabolome-wide association study of neovascular age-related macular degeneration. PLoS ONE. 2013; 8(8): e72737. PMID: 24015273, PMCID: PMC3754980, PII: PONE-D-13-06396, DOI: 10.1371/journal.pone.0072737, ISSN: 1932-6203.

Brantley MA, Osborn MP, Sanders BJ, Rezaei KA, Lu P, Li C, Milne GL, Cai J, Sternberg P. The short-term effects of antioxidant and zinc supplements on oxidative stress biomarker levels in plasma: a pilot investigation. Am. J. Ophthalmol [print-electronic]. 2012 Jun; 153(6): 1104-9.e2. PMID: 22381365, PMCID: PMC3358482, PII: S0002-9394(11)00990-1, DOI: 10.1016/j.ajo.2011.12.010, ISSN: 1879-1891.

Brantley MA, Osborn MP, Sanders BJ, Rezaei KA, Lu P, Li C, Milne GL, Cai J, Sternberg P. Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration. Am. J. Ophthalmol [print-electronic]. 2012 Mar; 153(3): 460-467.e1. PMID: 22035603, PMCID: PMC3288635, PII: S0002-9394(11)00675-1, DOI: 10.1016/j.ajo.2011.08.033, ISSN: 1879-1891.

Yu Y, Bhangale TR, Fagerness J, Ripke S, Thorleifsson G, Tan PL, Souied EH, Richardson AJ, Merriam JE, Buitendijk GH, Reynolds R, Raychaudhuri S, Chin KA, Sobrin L, Evangelou E, Lee PH, Lee AY, Leveziel N, Zack DJ, Campochiaro B, Campochiaro P, Smith RT, Barile GR, Guymer RH, Hogg R, Chakravarthy U, Robman LD, Gustafsson O, Sigurdsson H, Ortmann W, Behrens TW, Stefansson K, Uitterlinden AG, van Duijn CM, Vingerling JR, Klaver CC, Allikmets R, Brantley MA, Baird PN, Katsanis N, Thorsteinsdottir U, Ioannidis JP, Daly MJ, Graham RR, Seddon JM. Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum. Mol. Genet [print-electronic]. 2011 Sep 9/15/2011; 20(18): 3699-709. PMID: 21665990, PMCID: PMC3159552, PII: ddr270, DOI: 10.1093/hmg/ddr270, ISSN: 1460-2083.

Sheybani A, Brantley MA, Apte RS. Pattern electroretinography in age-related macular degeneration. Arch. Ophthalmol. 2011 May; 129(5): 580-4. PMID: 21555610, PII: 129/5/580, DOI: 10.1001/archophthalmol.2011.83, ISSN: 1538-3601.

Lee AY, Kulkarni M, Fang AM, Edelstein S, Osborn MP, Brantley MA. The effect of genetic variants in SERPING1 on the risk of neovascular age-related macular degeneration. Br J Ophthalmol. 2010 Jul; 94(7): 915-7. PMID: 20606025, PMCID: PMC3655725, PII: 94/7/915, DOI: 10.1136/bjo.2009.172007, ISSN: 1468-2079.

Neale BM, Fagerness J, Reynolds R, Sobrin L, Parker M, Raychaudhuri S, Tan PL, Oh EC, Merriam JE, Souied E, Bernstein PS, Li B, Frederick JM, Zhang K, Brantley MA, Lee AY, Zack DJ, Campochiaro B, Campochiaro P, Ripke S, Smith RT, Barile GR, Katsanis N, Allikmets R, Daly MJ, Seddon JM. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2010 Apr 4/20/2010; 107(16): 7395-400. PMID: 20385826, PMCID: PMC2867697, PII: 0912019107, DOI: 10.1073/pnas.0912019107, ISSN: 1091-6490.

Hegedus B, Hughes FW, Garbow JR, Gianino S, Banerjee D, Kim K, Ellisman MH, Brantley MA, Gutmann DH. Optic nerve dysfunction in a mouse model of neurofibromatosis-1 optic glioma. J. Neuropathol. Exp. Neurol. 2009 May; 68(5): 542-51. PMID: 19525901, PMCID: PMC2746323, PII: 00005072-200905000-00010, DOI: 10.1097/NEN.0b013e3181a3240b, ISSN: 0022-3069.

Lee AY, Raya AK, Kymes SM, Shiels A, Brantley MA. Pharmacogenetics of complement factor H (Y402H) and treatment of exudative age-related macular degeneration with ranibizumab. Br J Ophthalmol [print-electronic]. 2009 May; 93(5): 610-3. PMID: 19091853, PMCID: PMC3490485, PII: bjo.2008.150995, DOI: 10.1136/bjo.2008.150995, ISSN: 1468-2079.

Brantley MA, Edelstein SL, King JM, Plotzke MR, Apte RS, Kymes SM, Shiels A. Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to photodynamic therapy. Eye (Lond) [print-electronic]. 2009 Mar; 23(3): 626-31. PMID: 18292785, PII: eye200828, DOI: 10.1038/eye.2008.28, ISSN: 1476-5454.

Fang AM, Lee AY, Kulkarni M, Osborn MP, Brantley MA. Polymorphisms in the VEGFA and VEGFR-2 genes and neovascular age-related macular degeneration. Mol. Vis. 2009; 15: 2710-9. PMID: 20019880, PMCID: PMC2793900, PII: 287, ISSN: 1090-0535.

Lee AY, Brantley MA. CFH and LOC387715/ARMS2 genotypes and antioxidants and zinc therapy for age-related macular degeneration. Pharmacogenomics. 2008 Oct; 9(10): 1547-50. PMID: 18855541, DOI: 10.2217/14622416.9.10.1547, ISSN: 1744-8042.

Brantley MA, Jain S, Barr EE, Johnson EM, Milbrandt J. Neurturin-mediated ret activation is required for retinal function. J. Neurosci. 2008 Apr 4/16/2008; 28(16): 4123-35. PMID: 18417692, PMCID: PMC2704905, PII: 28/16/4123, DOI: 10.1523/JNEUROSCI.0249-08.2008, ISSN: 1529-2401.

Brantley MA, Fang AM, King JM, Tewari A, Kymes SM, Shiels A. Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to intravitreal bevacizumab. Ophthalmology. 2007 Dec; 114(12): 2168-73. PMID: 18054635, PII: S0161-6420(07)01026-3, DOI: 10.1016/j.ophtha.2007.09.008, ISSN: 1549-4713.

Michaelides M, Chen LL, Brantley MA, Andorf JL, Isaak EM, Jenkins SA, Holder GE, Bird AC, Stone EM, Webster AR. ABCA4 mutations and discordant ABCA4 alleles in patients and siblings with bull's-eye maculopathy. Br J Ophthalmol. 2007 Dec; 91(12): 1650-5. PMID: 18024811, PMCID: PMC2095527, PII: 91/12/1650, DOI: 10.1136/bjo.2007.118356, ISSN: 1468-2079.

Brantley MA, Edelstein SL, King JM, Apte RS, Kymes SM, Shiels A. Clinical phenotypes associated with the complement factor H Y402H variant in age-related macular degeneration. Am. J. Ophthalmol [print-electronic]. 2007 Sep; 144(3): 404-8. PMID: 17631852, PMCID: PMC2140051, PII: S0002-9394(07)00484-9, DOI: 10.1016/j.ajo.2007.05.018, ISSN: 0002-9394.

Zhu Y, Zhang Y, Ojwang BA, Brantley MA, Gidday JM. Long-term tolerance to retinal ischemia by repetitive hypoxic preconditioning: role of HIF-1alpha and heme oxygenase-1. Invest. Ophthalmol. Vis. Sci. 2007 Apr; 48(4): 1735-43. PMID: 17389506, PII: 48/4/1735, DOI: 10.1167/iovs.06-1037, ISSN: 0146-0404.

Knopf HL, Carter K, Council MD, Brantley MA. Peripapillary Hemorrhage. Compr Ophthalmol Update. 2007 Jan; 8(1): 53-4. PMID: 17394760, ISSN: 1527-7313.

Feiner L, Barr EE, Shui YB, Holekamp NM, Brantley MA. Safety of intravitreal injection of bevacizumab in rabbit eyes. Retina (Philadelphia, Pa.). 2006 Oct; 26(8): 882-8. PMID: 17031287, PII: 00006982-200610000-00005, DOI: 10.1097/01.iae.0000230717.85319.f5, ISSN: 0275-004X.

Michaelides M, Jenkins SA, Brantley MA, Andrews RM, Waseem N, Luong V, Gregory-Evans K, Bhattacharya SS, Fitzke FW, Webster AR. Maculopathy due to the R345W substitution in fibulin-3: distinct clinical features, disease variability, and extent of retinal dysfunction. Invest. Ophthalmol. Vis. Sci. 2006 Jul; 47(7): 3085-97. PMID: 16799055, PII: 47/7/3085, DOI: 10.1167/iovs.05-1600, ISSN: 0146-0404.

Mantel I, Brantley MA, Bellmann C, Robson AG, Holder GE, Taylor A, Anderson G, Moore AT. Juvenile neuronal ceroid lipofuscinosis (Batten disease) CLN3 mutation (Chrom 16p11.2) with different phenotypes in a sibling pair and low intensity in vivo autofluorescence. Klin Monbl Augenheilkd. 2004 May; 221(5): 427-30. PMID: 15162299, DOI: 10.1055/s-2004-812819, ISSN: 0023-2165.

Harbour JW, Brantley MA, Hollingsworth H, Gordon M. Association between choroidal pigmentation and posterior uveal melanoma in a white population. Br J Ophthalmol. 2004 Jan; 88(1): 39-43. PMID: 14693770, PMCID: PMC1771924, ISSN: 0007-1161.

Harbour JW, Brantley MA, Hollingsworth H, Gordon M. Association between posterior uveal melanoma and iris freckles, iris naevi, and choroidal naevi. Br J Ophthalmol. 2004 Jan; 88(1): 36-8. PMID: 14693769, PMCID: PMC1771959, ISSN: 0007-1161.

Joseph DP, Brantley MA, Grand MG. Serpiginouslike choroiditis in a patient with cardiac sarcoidosis. Retina (Philadelphia, Pa.). 2003 Feb; 23(1): 116-7. PMID: 12652246, ISSN: 0275-004X.

Brantley MA, Worley L, Harbour JW. Altered expression of Rb and p53 in uveal melanomas following plaque radiotherapy. Am. J. Ophthalmol. 2002 Feb; 133(2): 242-8. PMID: 11812429, PII: S0002939401013629, ISSN: 0002-9394.