Patrick S. Page-McCaw, Ph.D.

Research Assistant Professor
Faculty Appointments
Research Assistant Professor of Molecular Physiology and Biophysics Research Assistant Professor of Medicine
Ph.D., BIOLOGY, Massachusetts Institute of Technology, Cambridge, MassachusettsB.A., Haverford College, Haverford, Pennsylvania
Office Address
Light Hall 711H
2213 Garland Avenue
Nashville, TN 37232
Research Keywords
Genetics of autonomic regulation of the heart; Regulation of glycan metabolism in signaling; Insertional mutagenesis of the zebrafish
Westfall JE, Hoyt C, Liu Q, Hsiao YC, Pierce EA, Page-McCaw PS, Ferland RJ. Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1. J. Neurosci. 2010 Jun 6/30/2010; 30(26): 8759-68. PMID: 20592197, PMCID: PMC2923804, PII: 30/26/8759, DOI: 10.1523/JNEUROSCI.5229-09.2010, ISSN: 1529-2401.

Mann KD, Hoyt C, Feldman S, Blunt L, Raymond A, Page-McCaw PS. Cardiac response to startle stimuli in larval zebrafish: sympathetic and parasympathetic components. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2010 May; 298(5): R1288-97. PMID: 20130228, PII: 00302.2009, DOI: 10.1152/ajpregu.00302.2009, ISSN: 1522-1490.

Hsiao YC, Tong ZJ, Westfall JE, Ault JG, Page-McCaw PS, Ferland RJ. Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking. Hum. Mol. Genet [print-electronic]. 2009 Oct 10/15/2009; 18(20): 3926-41. PMID: 19625297, PMCID: PMC2748898, PII: ddp335, DOI: 10.1093/hmg/ddp335, ISSN: 1460-2083.

Zhang F, Zhang Z, Thistle R, McKeen L, Hosoyama S, Toida T, Linhardt RJ, Page-McCaw P. Structural characterization of glycosaminoglycans from zebrafish in different ages. Glycoconj. J [print-electronic]. 2009 Feb; 26(2): 211-8. PMID: 18777207, PMCID: PMC2643322, DOI: 10.1007/s10719-008-9177-x, ISSN: 1573-4986.

Doering JE, Kane K, Hsiao YC, Yao C, Shi B, Slowik AD, Dhagat B, Scott DD, Ault JG, Page-McCaw PS, Ferland RJ. Species differences in the expression of Ahi1, a protein implicated in the neurodevelopmental disorder Joubert syndrome, with preferential accumulation to stigmoid bodies. J. Comp. Neurol. 2008 Nov 11/10/2008; 511(2): 238-56. PMID: 18785627, PMCID: PMC2600576, DOI: 10.1002/cne.21824, ISSN: 1096-9861.

Muto A, Orger MB, Wehman AM, Smear MC, Kay JN, Page-McCaw PS, Gahtan E, Xiao T, Nevin LM, Gosse NJ, Staub W, Finger-Baier K, Baier H. Forward genetic analysis of visual behavior in zebrafish. PLoS Genet [print-electronic]. 2005 Nov; 1(5): e66. PMID: 16311625, PMCID: PMC1287954, DOI: 10.1371/journal.pgen.0010066, ISSN: 1553-7404.

Page-McCaw PS, Chung SC, Muto A, Roeser T, Staub W, Finger-Baier KC, Korenbrot JI, Baier H. Retinal network adaptation to bright light requires tyrosinase. Nat. Neurosci [print-electronic]. 2004 Dec; 7(12): 1329-36. PMID: 15516923, PII: nn1344, DOI: 10.1038/nn1344, ISSN: 1097-6256.

Orger MB, Gahtan E, Muto A, Page-McCaw P, Smear MC, Baier H. Behavioral screening assays in zebrafish. Methods Cell Biol. 2004; 77: 53-68. PMID: 15602905, ISSN: 0091-679X.

Page-McCaw PS, Amonlirdviman K, Sharp PA. PUF60: a novel U2AF65-related splicing activity. RNA. 1999 Dec; 5(12): 1548-60. PMID: 10606266, PMCID: PMC1369877, ISSN: 1355-8382.

Query CC, McCaw PS, Sharp PA. A minimal spliceosomal complex A recognizes the branch site and polypyrimidine tract. Mol. Cell. Biol. 1997 May; 17(5): 2944-53. PMID: 9111366, PMCID: PMC232146, ISSN: 0270-7306.

MacMillan AM, McCaw PS, Crispino JD, Sharp PA. SC35-mediated reconstitution of splicing in U2AF-depleted nuclear extract. Proc. Natl. Acad. Sci. U.S.A. 1997 Jan 1/7/1997; 94(1): 133-6. PMID: 8990173, PMCID: PMC19256, ISSN: 0027-8424.

Blencowe BJ, Issner R, Kim J, Mccaw P, Sharp PA. New proteins related to the Ser-Arg family of splicing factors. RNA. 1995 Oct; 1(8): 852-65. PMID: 7493330, PMCID: PMC1369325, ISSN: 1355-8382.

Murre C, McCaw PS, Vaessin H, Caudy M, Jan LY, Jan YN, Cabrera CV, Buskin JN, Hauschka SD, Lassar AB. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell. 1989 Aug 8/11/1989; 58(3): 537-44. PMID: 2503252, PII: 0092-8674(89)90434-0, ISSN: 0092-8674.

Murre C, McCaw PS, Baltimore D. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell. 1989 Mar 3/10/1989; 56(5): 777-83. PMID: 2493990, PII: 0092-8674(89)90682-X, ISSN: 0092-8674.