Daniel J. Moore, Ph.D., M.D.

Assistant Professor

daniel.moore@vanderbilt.edu

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Faculty Appointments
Assistant Professor of Pediatrics Assistant Professor of Pathology, Microbiology and Immunology
Education
M.D., MEDICINE, University of Pennsylvania, Philadelphia, PennsylvaniaPh.D., IMMUNOLOGY, University of Pennsylvania, Philadelphia, PennsylvaniaA.B., Harvard University, Cambridge, Massachusetts
Office Address
11136 DOT
2200 Children's Way
Nashville, TN 37232
Research Description
Our research seeks to understand the cellular and molecular mechanisms that govern immune tolerance in order to prevent and reverse Type 1 Diabetes and enhance the success of organ transplantation. My graduate research as an MSTP student at Penn contributed to the understanding of the role played by B lymphocytes in the development of autoimmune disease. This research formed part of the foundation for current efforts to use B cell directed therapies to prevent diabetes, studies in which Vanderbilt is participating through the Type 1 Diabetes TrialNet and for which I participate as a co-investigator. We also previously extended these studies to demonstrate that B lymphocytes are absolutely required for some forms of transplantation tolerance induction in murine models. These studies suggest the presence of regulatory B cells which have yet to be defined. A main present focus of the lab, supported by an NIH K08 and other sources, is to understand how B lymphocytes regulate immune tolerance to transplants and how this cell type participates in broken tolerance in autoimmune disease such as Type 1 diabetes.

As part of a comprehensive program to understand immune regulation, we also actively investigate the mechanism of action of regulatory T lymphocytes which are critical for the prevention of autoimmune disease and for the establishment of transplantation tolerance. This research has revealed several new interactions required for the development and function of these cells and has identified inflammation as a factor that counter-regulates these regulatory cells. To overcome this newly identified obstacle to immune tolerance, I collaborate with Jacek Hawiger, M.D., Ph.D. and we have successfully applied a new kind of anti-inflammatory therapy to the prevention of diabetes in a pre-clinical model of disease (PLOS One, 2010).

My research has been funded by the National Institutes of Health, the American Diabetes Association, and the Juvenile Diabetes Research Foundation. I serve as a reviewer for the Journal of Immunology, Diabetes, the American Journal of Transplantation, and the Annals of the New York Academy of Science. Our research has been presented at the Scientific Sessions of the American Diabetes Association, the annual meeting of the Pediatric Academic Societies, and the American Transplant Congress. We have published in the Journal of Immunology, Diabetes, Transplantation International, the Journal of Autoimmunity, and Nature Medicine. Our research program has also been recognized by the Society for Pediatric Research with the 2007 House Officer Research Award and by Vanderbilt University with the David Karzon, Joe M. Strayhorn, Elliot V. Newman, and Vanderbilt Scholar in Diabetes Awards.
Research Keywords
The overall goal of my research program is to induce life-long immune tolerance to specific self and foreign (transplantation) antigens in individuals with pre-existing autoimmune disease.
Clinical Research Keywords
Type 1 diabetes Immune Tolerance Transplantation Immunology
Publications
Stocks BT, Wilhelm AJ, Wilson CS, Marshall AF, Putnam NE, Major AS, Moore DJ. Lupus-Prone Mice Resist Immune Regulation and Transplant Tolerance Induction. Am. J. Transplant [print-electronic]. 2015 Sep 9/15/2015; PMID: 26372909, DOI: 10.1111/ajt.13449, ISSN: 1600-6143.

Datye KA, Moore DJ, Russell WE, Jaser SS. A review of adolescent adherence in type 1 diabetes and the untapped potential of diabetes providers to improve outcomes. Curr. Diab. Rep. 2015 Aug; 15(8): 621. PMID: 26084580, DOI: 10.1007/s11892-015-0621-6, ISSN: 1539-0829.

Wynn JL, Scumpia PO, Stocks BT, Romano-Keeler J, Alrifai MW, Liu JH, Kim AS, Alford CE, Matta P, Weitkamp JH, Moore DJ. Neonatal CD71+ Erythroid Cells Do Not Modify Murine Sepsis Mortality. J. Immunol [print-electronic]. 2015 Aug 8/1/2015; 195(3): 1064-70. PMID: 26101326, PMCID: PMC4506905, PII: jimmunol.1500771, DOI: 10.4049/jimmunol.1500771, ISSN: 1550-6606.

Sosenko JM, Skyler JS, DiMeglio LA, Beam CA, Krischer JP, Greenbaum CJ, Boulware D, Rafkin LE, Matheson D, Herold KC, Mahon J, Palmer JP, , . A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history. Diabetes Care [print-electronic]. 2015 Feb; 38(2): 271-6. PMID: 25519451, PMCID: PMC4302258, PII: dc14-1813, DOI: 10.2337/dc14-1813, ISSN: 1935-5548.

Wilson CS, Elizer SK, Marshall AF, Stocks BT, Moore DJ. Regulation of B lymphocyte responses to Toll-like receptor ligand binding during diabetes prevention in non-obese diabetic (NOD) mice. J Diabetes [print-electronic]. 2015 Jan 1/7/2015; PMID: 25564999, PMCID: PMC4598313, DOI: 10.1111/1753-0407.12263, ISSN: 1753-0407.

Zhao G, Moore DJ, Kim JI, Lee KM, O'Connor M, Yang M, Marshall AF, Lei J, Schuetz C, Markmann JF, Deng S. An immunosufficient murine model for the study of human islets. Xenotransplantation [print-electronic]. 2014 Nov; 21(6): 567-73. PMID: 25041432, PMCID: PMC4262653, DOI: 10.1111/xen.12126, ISSN: 1399-3089.

Mouledoux JH, Albers EL, Lu Z, Saville BR, Moore DJ, Dodd DA. Clinical predictors of autoimmune and severe atopic disease in pediatric heart transplant recipients. Pediatr Transplant [print-electronic]. 2014 Mar; 18(2): 197-203. PMID: 24372990, PMCID: PMC3988248, DOI: 10.1111/petr.12205, ISSN: 1399-3046.

Romano-Keeler J, Moore DJ, Wang C, Brucker RM, Fonnesbeck C, Slaughter JC, Li H, Curran DP, Meng S, Correa H, Lovvorn HN, Tang YW, Bordenstein S, George AL, Weitkamp JH. Early life establishment of site-specific microbial communities in the gut. Gut Microbes [print-electronic]. 2014 Mar; 5(2): 192-201. PMID: 24637795, PMCID: PMC4063844, PII: 28442, DOI: 10.4161/gmic.28442, ISSN: 1949-0984.

Weitkamp JH, Rosen MJ, Zhao Z, Koyama T, Geem D, Denning TL, Rock MT, Moore DJ, Halpern MD, Matta P, Denning PW. Small intestinal intraepithelial TCR¿d+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis. PLoS ONE. 2014; 9(6): e99042. PMID: 24905458, PMCID: PMC4048281, PII: PONE-D-14-10885, DOI: 10.1371/journal.pone.0099042, ISSN: 1932-6203.

Elizer SK, Marshall AF, Moore DJ. Dysregulation of T lymphocyte proliferative responses in autoimmunity. PLoS ONE. 2014; 9(8): e106347. PMID: 25171173, PMCID: PMC4149551, PII: PONE-D-13-30311, DOI: 10.1371/journal.pone.0106347, ISSN: 1932-6203.

DiGiandomenico A, Veach RA, Zienkiewicz J, Moore DJ, Wylezinski LS, Hutchens MA, Hawiger J. The "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation. PLoS ONE. 2014; 9(10): e110183. PMID: 25329889, PMCID: PMC4203769, PII: PONE-D-14-26863, DOI: 10.1371/journal.pone.0110183, ISSN: 1932-6203.

Sosenko JM, Skyler JS, Beam CA, Krischer JP, Greenbaum CJ, Mahon J, Rafkin LE, Matheson D, Herold KC, Palmer JP, . Acceleration of the loss of the first-phase insulin response during the progression to type 1 diabetes in diabetes prevention trial-type 1 participants. Diabetes [print-electronic]. 2013 Dec; 62(12): 4179-83. PMID: 23863814, PMCID: PMC3837047, PII: db13-0656, DOI: 10.2337/db13-0656, ISSN: 1939-327X.

Sosenko JM, Skyler JS, Palmer JP, Krischer JP, Yu L, Mahon J, Beam CA, Boulware DC, Rafkin L, Schatz D, Eisenbarth G, , . The prediction of type 1 diabetes by multiple autoantibody levels and their incorporation into an autoantibody risk score in relatives of type 1 diabetic patients. Diabetes Care [print-electronic]. 2013 Sep; 36(9): 2615-20. PMID: 23818528, PMCID: PMC3747899, PII: dc13-0425, DOI: 10.2337/dc13-0425, ISSN: 1935-5548.

Gregory JM, Moore DJ, Simmons JH. Type 1 diabetes mellitus. Pediatr Rev. 2013 May; 34(5): 203-15. PMID: 23637249, PII: 34/5/203, DOI: 10.1542/pir.34-5-203, ISSN: 1526-3347.

, , Buckingham BA, Beck RW, Ruedy KJ, Cheng P, Kollman C, Weinzimer SA, DiMeglio LA, Bremer AA, Slover R, Cantwell M. The effects of inpatient hybrid closed-loop therapy initiated within 1 week of type 1 diabetes diagnosis. Diabetes Technol. Ther [print-electronic]. 2013 May; 15(5): 401-8. PMID: 23570538, PMCID: PMC3643224, DOI: 10.1089/dia.2013.0002, ISSN: 1557-8593.

Yeh H, Moore DJ, Markmann JF, Kim JI. Mechanisms of regulatory T cell counter-regulation by innate immunity. Transplant Rev (Orlando) [print-electronic]. 2013 Apr; 27(2): 61-4. PMID: 23474287, PMCID: PMC3637936, PII: S0955-470X(13)00021-9, DOI: 10.1016/j.trre.2013.02.001, ISSN: 1557-9816.

Liu Y, Major AS, Zienkiewicz J, Gabriel CL, Veach RA, Moore DJ, Collins RD, Hawiger J. Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver. J Am Heart Assoc. 2013 Apr; 2(2): e000093. PMID: 23563994, PMCID: PMC3647260, PII: 2/2/e000093, DOI: 10.1161/JAHA.113.000093, ISSN: 2047-9980.

Weitkamp JH, Koyama T, Rock MT, Correa H, Goettel JA, Matta P, Oswald-Richter K, Rosen MJ, Engelhardt BG, Moore DJ, Polk DB. Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios. Gut [print-electronic]. 2013 Jan; 62(1): 73-82. PMID: 22267598, PMCID: PMC3606820, PII: gutjnl-2011-301551, DOI: 10.1136/gutjnl-2011-301551, ISSN: 1468-3288.

Virostko J, Radhika A, Poffenberger G, Dula AN, Moore DJ, Powers AC. Bioluminescence imaging reveals dynamics of beta cell loss in the non-obese diabetic (NOD) mouse model. PLoS ONE [print-electronic]. 2013; 8(3): e57784. PMID: 23483929, PMCID: PMC3590285, PII: PONE-D-12-38112, DOI: 10.1371/journal.pone.0057784, ISSN: 1932-6203.

Yu L, Boulware DC, Beam CA, Hutton JC, Wenzlau JM, Greenbaum CJ, Bingley PJ, Krischer JP, Sosenko JM, Skyler JS, Eisenbarth GS, Mahon JL, . Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies. Diabetes Care [print-electronic]. 2012 Jun; 35(6): 1213-8. PMID: 22446173, PMCID: PMC3357246, PII: dc11-2081, DOI: 10.2337/dc11-2081, ISSN: 1935-5548.

Shoemaker AH, Zienkiewicz J, Moore DJ. Clinical assessment of HNF1A and GCK variants and identification of a novel mutation causing MODY2. Diabetes Res. Clin. Pract [print-electronic]. 2012 May; 96(2): e36-9. PMID: 22341299, PMCID: PMC3560353, PII: S0168-8227(12)00058-7, DOI: 10.1016/j.diabres.2012.01.032, ISSN: 1872-8227.

Romano-Keeler J, Weitkamp JH, Moore DJ. Regulatory properties of the intestinal microbiome effecting the development and treatment of diabetes. Curr Opin Endocrinol Diabetes Obes. 2012 Apr; 19(2): 73-80. PMID: 22357099, PMCID: PMC3560352, DOI: 10.1097/MED.0b013e3283514d43, ISSN: 1752-2978.

Lin Q, Liu Y, Moore DJ, Elizer SK, Veach RA, Hawiger J, Ruley HE. Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes. J. Immunol [print-electronic]. 2012 Mar 3/15/2012; 188(6): 2493-7. PMID: 22323537, PMCID: PMC3294148, PII: jimmunol.1101502, DOI: 10.4049/jimmunol.1101502, ISSN: 1550-6606.

Engelhardt BG, Jagasia SM, Crowe JE, Griffith ML, Savani BN, Kassim AA, Lu P, Weitkamp JH, Moore DJ, Yoder SM, Rock MT, Jagasia M. Predicting posttransplantation diabetes mellitus by regulatory T-cell phenotype: implications for metabolic intervention to modulate alloreactivity. Blood [print-electronic]. 2012 Mar 3/8/2012; 119(10): 2417-21. PMID: 22262764, PMCID: PMC3311262, PII: blood-2011-10-384750, DOI: 10.1182/blood-2011-10-384750, ISSN: 1528-0020.

Buscariollo DL, Davidson MA, Black M, Russell WE, Rothman RL, Moore DJ. Factors that influence parental attitudes toward enrollment in type 1 diabetes trials. PLoS ONE [print-electronic]. 2012; 7(8): e44341. PMID: 22937171, PMCID: PMC3429434, PII: PONE-D-11-21531, DOI: 10.1371/journal.pone.0044341, ISSN: 1932-6203.

Mathew RP, Moore DJ. Autoimmune alternating hypo- and hyperthyroidism in children. Clin Pediatr (Phila) [print-electronic]. 2011 Nov; 50(11): 1040-4. PMID: 21700620, PMCID: PMC3556509, PII: 0009922811412583, DOI: 10.1177/0009922811412583, ISSN: 1938-2707.

Orban T, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JB, Monzavi R, Moran A, Raskin P, Rodriguez H, Russell WE, Schatz D, Wherrett D, Wilson DM, Krischer JP, Skyler JS, . Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet [print-electronic]. 2011 Jul 7/30/2011; 378(9789): 412-9. PMID: 21719096, PMCID: PMC3462593, PII: S0140-6736(11)60886-6, DOI: 10.1016/S0140-6736(11)60886-6, ISSN: 1474-547X.

Zhao G, Moore DJ, Kim JI, Lee KM, O'Connor MR, Duff PE, Yang M, Lei J, Markmann JF, Deng S. Inhibition of transplantation tolerance by immune senescence is reversed by endocrine modulation. Sci Transl Med. 2011 Jun 6/15/2011; 3(87): 87ra52. PMID: 21677198, PMCID: PMC3767303, PII: 3/87/87ra52, DOI: 10.1126/scitranslmed.3002270, ISSN: 1946-6242.

Gregory JM, Moore DJ. Can technological solutions for diabetes replace islet cell function?. Organogenesis [print-electronic]. 2011 Jan; 7(1): 32-41. PMID: 21289480, PMCID: PMC3082032, PII: 14028, ISSN: 1555-8592.

Kim JI, Sonawane SB, Lee MK, Lee SH, Duff PE, Moore DJ, O'Connor MR, Lian MM, Deng S, Choi Y, Yeh H, Caton AJ, Markmann JF. Blockade of GITR-GITRL interaction maintains Treg function to prolong allograft survival. Eur. J. Immunol. 2010 May; 40(5): 1369-74. PMID: 20148423, PMCID: PMC2935584, DOI: 10.1002/eji.200940046, ISSN: 1521-4141.

Zhao G, Moore DJ, Lee KM, Kim JI, Duff PE, O'Connor MR, Hirohashi T, Lei J, Yang M, Markmann JF, Deng S. An unexpected counter-regulatory role of IL-10 in B-lymphocyte-mediated transplantation tolerance. Am. J. Transplant [print-electronic]. 2010 Apr; 10(4): 796-801. PMID: 20199511, PMCID: PMC2934759, PII: AJT3027, DOI: 10.1111/j.1600-6143.2010.03027.x, ISSN: 1600-6143.

Moore DJ. Accounting for chance in the calculus of autoimmune disease. Med. Hypotheses [print-electronic]. 2010 Feb; 74(2): 289-93. PMID: 19800177, PMCID: PMC2815044, PII: S0306-9877(09)00614-8, DOI: 10.1016/j.mehy.2009.09.009, ISSN: 1532-2777.

Moore DJ, Zienkiewicz J, Kendall PL, Liu D, Liu X, Veach RA, Collins RD, Hawiger J. In vivo islet protection by a nuclear import inhibitor in a mouse model of type 1 diabetes. PLoS ONE. 2010; 5(10): e13235. PMID: 20949090, PMCID: PMC2950856, DOI: 10.1371/journal.pone.0013235, ISSN: 1932-6203.

Kim JI, Lee MK, Moore DJ, Sonawane SB, Duff PE, O'Connor MR, Yeh H, Lian MM, Deng S, Caton AJ, Markmann JF. Regulatory T-cell counter-regulation by innate immunity is a barrier to transplantation tolerance. Am. J. Transplant [print-electronic]. 2009 Dec; 9(12): 2736-44. PMID: 19845585, PMCID: PMC2796697, PII: AJT2847, DOI: 10.1111/j.1600-6143.2009.02847.x, ISSN: 1600-6143.

Sonawane SB, Kim JI, Lee MK, Lee SH, Duff PE, Moore DJ, Lian MM, Deng S, Choi Y, Yeh H, Caton AJ, Markmann JF. GITR Blockade Facilitates Treg Mediated Allograft Survival. Transplantation. 2009 Nov 11/27/2009; 88(10): 1169-77. PMID: 19935370, PMCID: PMC2803064, PII: 00007890-200911270-00005, DOI: 10.1097/TP.0b013e3181ba6f85, ISSN: 1534-6080.

Kendall PL, Moore DJ, Hulbert C, Hoek KL, Khan WN, Thomas JW. Reduced diabetes in btk-deficient nonobese diabetic mice and restoration of diabetes with provision of an anti-insulin IgH chain transgene. J. Immunol [print-electronic]. 2009 Nov 11/15/2009; 183(10): 6403-12. PMID: 19841184, PMCID: PMC2970569, PII: jimmunol.0900367, DOI: 10.4049/jimmunol.0900367, ISSN: 1550-6606.

Moore DJ, Gregory JM, Kumah-Crystal YA, Simmons JH. Mitigating micro-and macro-vascular complications of diabetes beginning in adolescence. Vasc Health Risk Manag [print-electronic]. 2009; 5: 1015-31. PMID: 19997571, PMCID: PMC2788594, ISSN: 1178-2048.

Huang X, Moore DJ, Ketchum RJ, Nunemaker CS, Kovatchev B, McCall AL, Brayman KL. Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation. Endocr. Rev [print-electronic]. 2008 Aug; 29(5): 603-30. PMID: 18664617, PMCID: PMC2819735, PII: er.2008-0006, DOI: 10.1210/er.2008-0006, ISSN: 0163-769X.

Porrett PM, Lee MK, Lian MM, Wang J, Caton AJ, Deng S, Markmann JF, Moore DJ. A direct comparison of rejection by CD8 and CD4 T cells in a transgenic model of allotransplantation. Arch. Immunol. Ther. Exp. (Warsz.) [print-electronic]. 2008 May; 56(3): 193-200. PMID: 18512028, PMCID: PMC2766493, DOI: 10.1007/s00005-008-0019-0, ISSN: 0004-069X.

Huang X, Moore DJ, Mohiuddin M, Lian MM, Kim JI, Sonawane S, Wang J, Gu Y, Yeh H, Markmann JF, Deng S. Inhibition of ICAM-1/LFA-1 interactions prevents B-cell-dependent anti-CD45RB-induced transplantation tolerance. Transplantation. 2008 Mar 3/15/2008; 85(5): 675-80. PMID: 18337659, PMCID: PMC2934773, PII: 00007890-200803150-00005, DOI: 10.1097/TP.0b013e3181663422, ISSN: 0041-1337.

Deng S, Moore DJ, Huang X, Lian MM, Mohiuddin M, Velededeoglu E, Lee MK, Sonawane S, Kim J, Wang J, Chen H, Corfe SA, Paige C, Shlomchik M, Caton A, Markmann JF. Cutting edge: transplant tolerance induced by anti-CD45RB requires B lymphocytes. J. Immunol. 2007 May 5/15/2007; 178(10): 6028-32. PMID: 17475825, PII: 178/10/6028, ISSN: 0022-1767.

Moore DJ, Kim JI, Sonawane S, Yeh H, Deng S, Lee K, Markmann JF. Progress toward antibody-induced transplantation tolerance. Crit. Rev. Immunol. 2007; 27(2): 167-218. PMID: 17725502, PII: 04b273632c9e9613,2f614a3f72acaf13, ISSN: 1040-8401.

Moore DJ, Markmann JF, Deng S. Avenues for immunomodulation and graft protection by gene therapy in transplantation. Transpl. Int. 2006 Jun; 19(6): 435-45. PMID: 16771864, PII: TRI314, DOI: 10.1111/j.1432-2277.2006.00314.x, ISSN: 0934-0874.

Lee MK, Moore DJ, Chiaccio M, Lian MM, Deng S, Mohiuddin M, Huang X, Koeberlein B, Zakheim A, Porrett PM, Barker CF, Caton AJ, Markmann JF. T-reg mediated suppression of the allograft response in the draining lymph node. Transplantation. 2006 Apr 4/15/2006; 81(7): 1063-6. PMID: 16612285, PII: 00007890-200604150-00022, DOI: 10.1097/01.tp.0000168365.80771.5a, ISSN: 0041-1337.

Deng S, Moore DJ, Huang X, Mohiuddin M, Lee MK, Velidedeoglu E, Lian MM, Chiaccio M, Sonawane S, Orlin A, Wang J, Chen H, Caton A, Zhong R, Markmann JF. Antibody-induced transplantation tolerance that is dependent on thymus-derived regulatory T cells. J. Immunol. 2006 Mar 3/1/2006; 176(5): 2799-807. PMID: 16493036, PII: 176/5/2799, ISSN: 0022-1767.

Wilde GE, Moore DJ, Bellah RD. Posttransplantation lymphoproliferative disorder in pediatric recipients of solid organ transplants: timing and location of disease. AJR Am J Roentgenol. 2005 Nov; 185(5): 1335-41. PMID: 16247159, PII: 185/5/1335, DOI: 10.2214/AJR.04.1546, ISSN: 0361-803X.

Moore DJ, Noorchashm H, Lin TH, Greeley SA, Naji A. NOD B-cells are insufficient to incite T-cell-mediated anti-islet autoimmunity. Diabetes. 2005 Jul; 54(7): 2019-25. PMID: 15983202, PII: 54/7/2019, ISSN: 0012-1797.

Lee MK, Moore DJ, Jarrett BP, Lian MM, Deng S, Huang X, Markmann JW, Chiaccio M, Barker CF, Caton AJ, Markmann JF. Promotion of allograft survival by CD4+CD25+ regulatory T cells: evidence for in vivo inhibition of effector cell proliferation. J. Immunol. 2004 Jun 6/1/2004; 172(11): 6539-44. PMID: 15153467, ISSN: 0022-1767.

Moore DJ, Huang X, Lee MK, Lian MM, Chiaccio M, Chen H, Koeberlein B, Zhong R, Markmann JF, Deng S. Resistance to anti-CD45RB-induced tolerance in NOD mice: mechanisms involved. Transpl. Int [print-electronic]. 2004 Jun; 17(5): 261-9. PMID: 15138669, DOI: 10.1007/s00147-004-0698-3, ISSN: 0934-0874.

Song HK, Noorchashm H, Lin TH, Moore DJ, Greeley SA, Caton AJ, Naji A. Specialized CC-chemokine secretion by Th1 cells in destructive autoimmune myocarditis. J. Autoimmun. 2003 Dec; 21(4): 295-303. PMID: 14624753, PII: S0896841103001100, ISSN: 0896-8411.

Lee MK, Moore DJ, Markmann JF. Regulatory CD4+CD25+T cells in prevention of allograft rejection. Front. Biosci. 2003 Sep 9/1/2003; 8: s968-81. PMID: 12957865, ISSN: 1093-9946.

Lee MK, Huang X, Jarrett BP, Moore DJ, Desai NM, Moh Lian M, Markmann JW, Deng S, Frank A, Singer A, Velidedeoglu E, Caton AJ, Markmann AJ. Vulnerability of allografts to rejection by MHC class II-restricted T-cell receptor transgenic mice. Transplantation. 2003 Apr 4/27/2003; 75(8): 1415-22. PMID: 12717241, DOI: 10.1097/01.TP.0000064296.65628.6C, ISSN: 0041-1337.

Trani J, Moore DJ, Jarrett BP, Markmann JW, Lee MK, Singer A, Lian MM, Tran B, Caton AJ, Markmann JF. CD25+ immunoregulatory CD4 T cells mediate acquired central transplantation tolerance. J. Immunol. 2003 Jan 1/1/2003; 170(1): 279-86. PMID: 12496410, ISSN: 0022-1767.

Velidedeoglu E, Jarret B, Lee K, Moore D, Huang X, Deng S, Lian MM, Caton A, Markmann JF. Transgenic T cells persist in an adoptive transfer model of mouse liver transplantation tolerance. Transplant. Proc. 2002 Dec; 34(8): 3342-4. PMID: 12493468, PII: S0041134502036965, ISSN: 0041-1345.

Greeley SA, Katsumata M, Yu L, Eisenbarth GS, Moore DJ, Goodarzi H, Barker CF, Naji A, Noorchashm H. Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice. Nat. Med. 2002 Apr; 8(4): 399-402. PMID: 11927947, PII: nm0402-399, DOI: 10.1038/nm0402-399, ISSN: 1078-8956.

Greeley SA, Moore DJ, Noorchashm H, Noto LE, Rostami SY, Schlachterman A, Song HK, Koeberlein B, Barker CF, Naji A. Impaired activation of islet-reactive CD4 T cells in pancreatic lymph nodes of B cell-deficient nonobese diabetic mice. J. Immunol. 2001 Oct 10/15/2001; 167(8): 4351-7. PMID: 11591759, ISSN: 0022-1767.

Kline JB, Moore DJ, Clevenger CV. Activation and association of the Tec tyrosine kinase with the human prolactin receptor: mapping of a Tec/Vav1-receptor binding site. Mol. Endocrinol. 2001 May; 15(5): 832-41. PMID: 11328862, DOI: 10.1210/mend.15.5.0631, ISSN: 0888-8809.

Noorchashm H, Moore DJ, Noto LE, Noorchashm N, Reed AJ, Reed AL, Song HK, Mozaffari R, Jevnikar AM, Barker CF, Naji A. Impaired CD4 T cell activation due to reliance upon B cell-mediated costimulation in nonobese diabetic (NOD) mice. J. Immunol. 2000 Oct 10/15/2000; 165(8): 4685-96. PMID: 11035112, ISSN: 0022-1767.

Shimada H, Germana S, Sonntag KC, Banerjee P, Moore D, Sachs DH, LeGuern C. MHC class II alpha/beta heterodimeric cell surface molecules expressed from a single proviral genome. Hum. Gene Ther. 1999 Sep 9/20/1999; 10(14): 2397-405. PMID: 10515459, DOI: 10.1089/10430349950017040, ISSN: 1043-0342.

Noorchashm H, Moore DJ, Lieu YK, Noorchashm N, Schlachterman A, Song HK, Barker CF, Naji A. Contribution of the innate immune system to autoimmune diabetes: a role for the CR1/CR2 complement receptors. Cell. Immunol. 1999 Jul 7/10/1999; 195(1): 75-9. PMID: 10433799, PII: S0008874999915228, DOI: 10.1006/cimm.1999.1522, ISSN: 0008-8749.

Available Postdoctoral Position Details
We would welcome a highly motivated, energetic investigator to join our team and lead a translational project defining new models of human autoimmune disease. Experience in human immunology, mouse models of autoimmunity and diabetes, and methods in cellular and molecular immunology is highly desirable.