Michael E. Matheny, M.D.

Assistant Professor


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Faculty Appointments
Assistant Professor of Biomedical Informatics Assistant Professor of MedicineAssistant Professor in Biostatistics
M.P.H., Harvard University, Cambridge, MassachusettsM.S., Biomedical Informatics, Massachusetts Institute of Technology, Cambridge, MassachusettsM.D., MEDICINE, University of Kentucky, Lexington, KentuckyB.S., Chemical Engineering, University of Kentucky, Lexington, Kentucky
Office Address
Department of Veterans Affairs
1310 24th Ave so
Nashville, TN 37212
Reeves RM, Ong FR, Matheny ME, Denny JC, Aronsky D, Gobbel GT, Montella D, Speroff T, Brown SH. Detecting temporal expressions in medical narratives. Int J Med Inform [print-electronic]. 2013 Feb; 82(2): 118-27. PMID: 22595284, PII: S1386-5056(12)00073-1, DOI: 10.1016/j.ijmedinf.2012.04.006, ISSN: 1872-8243.

Liu M, Wu Y, Chen Y, Sun J, Zhao Z, Chen XW, Matheny ME, Xu H. Large-scale prediction of adverse drug reactions using chemical, biological, and phenotypic properties of drugs. J Am Med Inform Assoc. 2012 Jun; 19(e1): e28-35. PMID: 22718037, PMCID: PMC3392844, PII: amiajnl-2011-000699, DOI: 10.1136/amiajnl-2011-000699, ISSN: 1527-974X.

Siew ED, Ikizler TA, Matheny ME, Shi Y, Schildcrout JS, Danciu I, Dwyer JP, Srichai M, Hung AM, Smith JP, Peterson JF. Estimating baseline kidney function in hospitalized patients with impaired kidney function. Clin J Am Soc Nephrol [print-electronic]. 2012 May; 7(5): 712-9. PMID: 22422536, PMCID: PMC3338282, PII: CJN.10821011, DOI: 10.2215/CJN.10821011, ISSN: 1555-905X.

Siew ED, Peterson JF, Eden SK, Hung AM, Speroff T, Ikizler TA, Matheny ME. Outpatient nephrology referral rates after acute kidney injury. J. Am. Soc. Nephrol [print-electronic]. 2012 Feb; 23(2): 305-12. PMID: 22158435, PMCID: PMC3269178, PII: ASN.2011030315, DOI: 10.1681/ASN.2011030315, ISSN: 1533-3450.

Schildcrout JS, Haneuse S, Peterson JF, Denny JC, Matheny ME, Waitman LR, Miller RA. Analyses of longitudinal, hospital clinical laboratory data with application to blood glucose concentrations. Stat Med [print-electronic]. 2011 Nov 11/30/2011; 30(27): 3208-20. PMID: 21948391, PMCID: PMC3339442, DOI: 10.1002/sim.4352, ISSN: 1097-0258.

Murff HJ, FitzHenry F, Matheny ME, Gentry N, Kotter KL, Crimin K, Dittus RS, Rosen AK, Elkin PL, Brown SH, Speroff T. Automated identification of postoperative complications within an electronic medical record using natural language processing. JAMA. 2011 Aug 8/24/2011; 306(8): 848-55. PMID: 21862746, PII: 306/8/848, DOI: 10.1001/jama.2011.1204, ISSN: 1538-3598.

FitzHenry F, Doran J, Lobo B, Sullivan TM, Potts A, Feldott CC, Matheny ME, McCulloch G, Deppen S, Doulis J. Medication-error alerts for warfarin orders detected by a bar-code-assisted medication administration system. Am J Health Syst Pharm. 2011 Mar 3/1/2011; 68(5): 434-41. PMID: 21330686, PII: 68/5/434, DOI: 10.2146/ajhp090666, ISSN: 1535-2900.

Matheny ME, Normand SL, Gross TP, Marinac-Dabic D, Loyo-Berrios N, Vidi VD, Donnelly S, Resnic FS. Evaluation of an automated safety surveillance system using risk adjusted sequential probability ratio testing. BMC Med Inform Decis Mak. 2011; 11: 75. PMID: 22168892, PMCID: PMC3262755, PII: 1472-6947-11-75, DOI: 10.1186/1472-6947-11-75, ISSN: 1472-6947.

Matheny ME, Miller RA, Ikizler TA, Waitman LR, Denny JC, Schildcrout JS, Dittus RS, Peterson JF. Development of inpatient risk stratification models of acute kidney injury for use in electronic health records. Med Decis Making [print-electronic]. 2010 Nov; 30(6): 639-50. PMID: 20354229, PII: 0272989X10364246, DOI: 10.1177/0272989X10364246, ISSN: 1552-681X.

Siew ED, Matheny ME, Ikizler TA, Lewis JB, Miller RA, Waitman LR, Go AS, Parikh CR, Peterson JF. Commonly used surrogates for baseline renal function affect the classification and prognosis of acute kidney injury. Kidney Int [print-electronic]. 2010 Mar; 77(6): 536-42. PMID: 20042998, PMCID: PMC2929703, PII: ki2009479, DOI: 10.1038/ki.2009.479, ISSN: 1523-1755.

Tiroch KA, Matheny ME, Resnic FS. Quantitative impact of cardiovascular risk factors and vascular closure devices on the femoral artery after repeat cardiac catheterization. Am. Heart J. 2010 Jan; 159(1): 125-30. PMID: 20102878, PMCID: PMC2818977, PII: S0002-8703(09)00820-5, DOI: 10.1016/j.ahj.2009.10.023, ISSN: 1097-6744.

Hug BL, Witkowski DJ, Sox CM, Keohane CA, Seger DL, Yoon C, Matheny ME, Bates DW. Adverse drug event rates in six community hospitals and the potential impact of computerized physician order entry for prevention. J Gen Intern Med [print-electronic]. 2010 Jan; 25(1): 31-8. PMID: 19894081, PMCID: PMC2811587, DOI: 10.1007/s11606-009-1141-3, ISSN: 1525-1497.

Peterson JF, Shi Y, Denny JC, Matheny ME, Schildcrout JS, Waitman LR, Miller RA. Prevalence and Clinical Significance of Discrepancies within Three Computerized Pre-Admission Medication Lists. AMIA Annu Symp Proc. 2010; 2010: 642-6. PMID: 21347057, PMCID: PMC3041392, ISSN: 1942-597X.

Hug BL, Witkowski DJ, Sox CM, Keohane CA, Seger DL, Yoon C, Matheny ME, Bates DW. Occurrence of adverse, often preventable, events in community hospitals involving nephrotoxic drugs or those excreted by the kidney. Kidney Int [print-electronic]. 2009 Dec; 76(11): 1192-8. PMID: 19759525, PII: ki2009353, DOI: 10.1038/ki.2009.353, ISSN: 1523-1755.

Turchin A, Matheny ME, Shubina M, Scanlon JV, Greenwood B, Pendergrass ML. Hypoglycemia and clinical outcomes in patients with diabetes hospitalized in the general ward. Diabetes Care. 2009 Jul; 32(7): 1153-7. PMID: 19564471, PMCID: PMC2699723, PII: 32/7/1153, DOI: 10.2337/dc08-2127, ISSN: 1935-5548.

Ahmed BA, Matheny ME, Rice PL, Clarke JR, Ogunyemi OI. A comparison of methods for assessing penetrating trauma on retrospective multi-center data. J Biomed Inform [print-electronic]. 2009 Apr; 42(2): 308-16. PMID: 18929685, PMCID: PMC2693228, PII: S1532-0464(08)00123-8, DOI: 10.1016/j.jbi.2008.09.002, ISSN: 1532-0480.

Matheny ME, Morrow DA, Ohno-Machado L, Cannon CP, Sabatine MS, Resnic FS. Validation of an automated safety surveillance system with prospective, randomized trial data. Med Decis Making [print-electronic]. 2009 Mar; 29(2): 247-56. PMID: 19015285, PMCID: PMC2743924, PII: 0272989X08327110, DOI: 10.1177/0272989X08327110, ISSN: 0272-989X.

Lo HG, Matheny ME, Seger DL, Bates DW, Gandhi TK. Impact of non-interruptive medication laboratory monitoring alerts in ambulatory care. J Am Med Inform Assoc [print-electronic]. 2009 Jan; 16(1): 66-71. PMID: 18952945, PMCID: PMC2605597, PII: M2687, DOI: 10.1197/jamia.M2687, ISSN: 1067-5027.

Matheny ME, Fitzhenry F, Speroff T, Hathaway J, Murff HJ, Brown SH, Fielstein EM, Dittus RS, Elkin PL. Detection of blood culture bacterial contamination using natural language processing. AMIA Annu Symp Proc. 2009; 2009: 411-5. PMID: 20351890, PMCID: PMC2815455, ISSN: 1942-597X.

Tiroch KA, Arora N, Matheny ME, Liu C, Lee TC, Resnic FS. Risk predictors of retroperitoneal hemorrhage following percutaneous coronary intervention. Am. J. Cardiol [print-electronic]. 2008 Dec 12/1/2008; 102(11): 1473-6. PMID: 19026298, PII: S0002-9149(08)01264-2, DOI: 10.1016/j.amjcard.2008.07.039, ISSN: 1879-1913.

Matheny ME, Sequist TD, Seger AC, Fiskio JM, Sperling M, Bugbee D, Bates DW, Gandhi TK. A randomized trial of electronic clinical reminders to improve medication laboratory monitoring. J Am Med Inform Assoc [print-electronic]. 2008 Jul; 15(4): 424-9. PMID: 18436905, PMCID: PMC2442256, PII: M2602, DOI: 10.1197/jamia.M2602, ISSN: 1067-5027.

Matheny ME, Shubina M, Kimmel ZM, Pendergrass ML, Turchin A. Treatment intensification and blood glucose control among hospitalized diabetic patients. J Gen Intern Med [print-electronic]. 2008 Feb; 23(2): 184-9. PMID: 18066630, PMCID: PMC2359170, DOI: 10.1007/s11606-007-0468-x, ISSN: 1525-1497.

Matheny ME, Ohno-Machado L, Resnic FS. Risk-adjusted sequential probability ratio test control chart methods for monitoring operator and institutional mortality rates in interventional cardiology. Am. Heart J [print-electronic]. 2008 Jan; 155(1): 114-20. PMID: 18082501, PII: S0002-8703(07)00708-9, DOI: 10.1016/j.ahj.2007.08.022, ISSN: 1097-6744.

FitzHenry F, Doran JB, Matheny ME, Rudge NK, Waitman LR, Sullivan M, Peterson JF. BCMA evaluation: finding significance in near misses. AMIA Annu Symp Proc. 2008; 943. PMID: 18999154, ISSN: 1942-597X.

Matheny ME, Resnic FS, Arora N, Ohno-Machado L. Effects of SVM parameter optimization on discrimination and calibration for post-procedural PCI mortality. J Biomed Inform [print-electronic]. 2007 Dec; 40(6): 688-97. PMID: 17600771, PMCID: PMC2170520, PII: S1532-0464(07)00049-4, DOI: 10.1016/j.jbi.2007.05.008, ISSN: 1532-0480.

Matheny ME, Gandhi TK, Orav EJ, Ladak-Merchant Z, Bates DW, Kuperman GJ, Poon EG. Impact of an automated test results management system on patients' satisfaction about test result communication. Arch. Intern. Med. 2007 Nov 11/12/2007; 167(20): 2233-9. PMID: 17998497, PII: 167/20/2233, DOI: 10.1001/archinte.167.20.2233, ISSN: 0003-9926.

Arora N, Matheny ME, Sepke C, Resnic FS. A propensity analysis of the risk of vascular complications after cardiac catheterization procedures with the use of vascular closure devices. Am. Heart J. 2007 Apr; 153(4): 606-11. PMID: 17383300, PII: S0002-8703(07)00045-2, DOI: 10.1016/j.ahj.2006.12.014, ISSN: 1097-6744.

Resnic FS, Arora N, Matheny M, Reynolds MR. A cost-minimization analysis of the angio-seal vascular closure device following percutaneous coronary intervention. Am. J. Cardiol [print-electronic]. 2007 Mar 3/15/2007; 99(6): 766-70. PMID: 17350361, PMCID: PMC1864959, PII: S0002-9149(06)02363-0, DOI: 10.1016/j.amjcard.2006.10.032, ISSN: 0002-9149.

Matheny ME, Arora N, Ohno-Machado L, Resnic FS. Rare adverse event monitoring of medical devices with the use of an automated surveillance tool. AMIA Annu Symp Proc. 2007; 518-22. PMID: 18693890, PMCID: PMC2655807, ISSN: 1942-597X.

Matheny ME, Morrow DA, Ohno-Machado L, Cannon CP, Resnic FS. Validating an automated outcomes surveillance application using data from a terminated randomized, controlled trial (OPUS [TIMI-16]). AMIA Annu Symp Proc. 2007; 1043. PMID: 18694141, ISSN: 1942-597X.

Lo HG, Matheny ME, Seger DL, Bates DW, Gandhi TK. Non-interruptive drug-lab alerts in ambulatory care. AMIA Annu Symp Proc. 2007; 1038. PMID: 18694136, ISSN: 1942-597X.

Matheny ME, Ohno-Machado L, Resnic FS. Monitoring device safety in interventional cardiology. J Am Med Inform Assoc [print-electronic]. 2006 Mar; 13(2): 180-7. PMID: 16357356, PMCID: PMC1447549, PII: M1908, DOI: 10.1197/jamia.M1908, ISSN: 1067-5027.

Ohno-Machado L, Resnic FS, Matheny ME. Prognosis in critical care. Annu Rev Biomed Eng. 2006; 8: 567-99. PMID: 16834567, DOI: 10.1146/annurev.bioeng.8.061505.095842, ISSN: 1523-9829.

Matheny ME, Ohno-Machado L, Resnic FS. Discrimination and calibration of mortality risk prediction models in interventional cardiology. J Biomed Inform [print-electronic]. 2005 Oct; 38(5): 367-75. PMID: 16198996, PII: S1532-0464(05)00019-5, DOI: 10.1016/j.jbi.2005.02.007, ISSN: 1532-0464.

Matheny ME, Ogunyemi OI, Rice PL, Clarke JR. Evaluating the discriminatory power of a computer-based system for assessing penetrating trauma on retrospective multi-center data. AMIA Annu Symp Proc. 2005; 500-4. PMID: 16779090, PMCID: PMC1479848, PII: 58319, ISSN: 1942-597X.