Ronald C. Walker, M.D.

Professor of Clinical
Faculty Appointments
Professor of Clinical Radiology and Radiological Sciences
M.D., M.D., NOT APPLICABLE, Baylor College of Medicine, Houston, TexasB.S., Biology, Baylor University, Waco, Texas
Research Description
PET imaging and research, particularly in multiple myeloma; PET-CT in oncology; imaging of neuroendocrine tumors, including with 68Ga-DOTATATE, Peptide Receptor Radionuclide Therapy (PRRT) for neuroendocrine tumors with 177Lu-DOTATATE, and quantitative imaging of indeterminate lung nodules with both CT and PET-CT, including the use of novel radiopharmaceuticals, lung cancer screening.

Graduate medical education in diagnostic radiology and in nuclear medicine, especially in PET-CT and CT.

Fellow of the American College of Radiology and Fellow of the American College of Nuclear Medicine
Clinical Description
Active in NIH/NCI funded lung cancer screening program at Vanderbilt; active in all aspects of clinical nuclear medicine at Vanderbilt University Medical Center, Vanderbilt Children's Hospital, and Tennessee Valley VA Healthcare System.
Research Keywords
PET Imaging and Research, PET-CT in Oncology and Lung Cancer Screening
Clinical Research Keywords
lung cancer imaging; lung cancer screening, neuroendocrine tumors, hematology/oncology imaging, radionuclide therapy of cancer.
Deppen SA, Blume J, Bobbey AJ, Shah C, Graham MM, Lee P, Delbeke D, Walker RC. 68Ga-DOTATATE Compared with 111In-DTPA-Octreotide and Conventional Imaging for Pulmonary and Gastroenteropancreatic Neuroendocrine Tumors: A Systematic Review and Meta-Analysis. J. Nucl. Med [print-electronic]. 2016 Jun; 57(6): 872-8. PMID: 26769864, PII: jnumed.115.165803, DOI: 10.2967/jnumed.115.165803, ISSN: 1535-5667.

Gifford A, Towse TF, Walker RC, Avison MJ, Welch EB. Characterizing Active and Inactive Brown Adipose Tissue in Adult Humans Using PET-CT and MR Imaging. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2016 May 5/10/2016; ajpendo.00482.2015. PMID: 27166284, PII: ajpendo.00482.2015, DOI: 10.1152/ajpendo.00482.2015, ISSN: 1522-1555.

Deppen SA, Liu E, Blume JD, Clanton J, Shi C, Jones-Jackson LB, Lakhani V, Baum RP, Berlin J, Smith GT, Graham M, Sandler MP, Delbeke D, Walker RC. Safety and Efficacy of 68Ga-DOTATATE PET/CT for Diagnosis, Staging, and Treatment Management of Neuroendocrine Tumors. J. Nucl. Med [print-electronic]. 2016 May; 57(5): 708-14. PMID: 26769865, PII: jnumed.115.163865, DOI: 10.2967/jnumed.115.163865, ISSN: 1535-5667.

Sherrod AM, Hari P, Mosse CA, Walker RC, Cornell RF. Minimal residual disease testing after stem cell transplantation for multiple myeloma. Bone Marrow Transplant [print-electronic]. 2016 Jan; 51(1): 2-12. PMID: 26191950, PII: bmt2015164, DOI: 10.1038/bmt.2015.164, ISSN: 1476-5365.

Gifford A, Walker RC, Towse TF, Brian Welch E. Correlations between quantitative fat-water magnetic resonance imaging and computed tomography in human subcutaneous white adipose tissue. J Med Imaging (Bellingham) [print-electronic]. 2015 Oct; 2(4): 46001. PMID: 26702407, PMCID: PMC4684077, PII: 15121RR, DOI: 10.1117/1.JMI.2.4.046001, ISSN: 2329-4302.

McKinley ET, Watchmaker JM, Chakravarthy AB, Meyerhardt JA, Engelman JA, Walker RC, Washington MK, Coffey RJ, Manning HC. [(18)F]-FLT PET to predict early response to neoadjuvant therapy in KRAS wild-type rectal cancer: a pilot study. Ann Nucl Med [print-electronic]. 2015 Jul; 29(6): 535-42. PMID: 25899481, PMCID: PMC4503488, DOI: 10.1007/s12149-015-0974-6, ISSN: 1864-6433.

Gifford A, Towse TF, Walker RC, Avison MJ, Welch EB. Human brown adipose tissue depots automatically segmented by positron emission tomography/computed tomography and registered magnetic resonance images. J Vis Exp. 2015; (96): PMID: 25741672, PMCID: PMC4354647, DOI: 10.3791/52415, ISSN: 1940-087X.

Smith GT, Rahman AR, Li M, Moore B, Gietema H, Veronesi G, Massion PP, Walker RC. Reproducibility of Volumetric Computed Tomography of Stable Small Pulmonary Nodules with Implications on Estimated Growth Rate and Optimal Scan Interval. PLoS ONE. 2015; 10(9): e0138144. PMID: 26379272, PMCID: PMC4575025, PII: PONE-D-15-09876, DOI: 10.1371/journal.pone.0138144, ISSN: 1932-6203.

Massion PP, Walker RC. Indeterminate pulmonary nodules: risk for having or for developing lung cancer?. Cancer Prev Res (Phila) [print-electronic]. 2014 Dec; 7(12): 1173-8. PMID: 25348855, PMCID: PMC4829944, PII: 1940-6207.CAPR-14-0364, DOI: 10.1158/1940-6207.CAPR-14-0364, ISSN: 1940-6215.

Deppen SA, Blume JD, Aldrich MC, Fletcher SA, Massion PP, Walker RC, Chen HC, Speroff T, Degesys CA, Pinkerman R, Lambright ES, Nesbitt JC, Putnam JB, Grogan EL. Predicting lung cancer prior to surgical resection in patients with lung nodules. J Thorac Oncol. 2014 Oct; 9(10): 1477-84. PMID: 25170644, PMCID: PMC4272613, PII: S1556-0864(15)30704-8, DOI: 10.1097/JTO.0000000000000287, ISSN: 1556-1380.

Deppen SA, Blume JD, Kensinger CD, Morgan AM, Aldrich MC, Massion PP, Walker RC, McPheeters ML, Putnam JB, Grogan EL. Accuracy of FDG-PET to diagnose lung cancer in areas with infectious lung disease: a meta-analysis. JAMA. 2014 Sep 9/24/2014; 312(12): 1227-36. PMID: 25247519, PMCID: PMC4315183, PII: 1906615, DOI: 10.1001/jama.2014.11488, ISSN: 1538-3598.

Walker RC, Smith GT, Liu E, Moore B, Clanton J, Stabin M. Measured human dosimetry of 68Ga-DOTATATE. J. Nucl. Med [print-electronic]. 2013 Jun; 54(6): 855-60. PMID: 23516312, PMCID: PMC4472480, PII: jnumed.112.114165, DOI: 10.2967/jnumed.112.114165, ISSN: 1535-5667.

McKinley ET, Smith RA, Tanksley JP, Washington MK, Walker R, Coffey RJ, Manning HC. [18F]FLT-PET to predict pharmacodynamic and clinical response to cetuximab therapy in Ménétrier's disease. Ann Nucl Med [print-electronic]. 2012 Nov; 26(9): 757-63. PMID: 22821337, PMCID: PMC3543701, DOI: 10.1007/s12149-012-0636-x, ISSN: 1864-6433.

Walker RC, Brown TL, Jones-Jackson LB, De Blanche L, Bartel T. Imaging of multiple myeloma and related plasma cell dyscrasias. J. Nucl. Med [print-electronic]. 2012 Jul; 53(7): 1091-101. PMID: 22693310, PII: jnumed.111.098830, DOI: 10.2967/jnumed.111.098830, ISSN: 1535-5667.

Grogan EL, Weinstein JJ, Deppen SA, Putnam JB, Nesbitt JC, Lambright ES, Walker RC, Dittus RS, Massion PP. Thoracic operations for pulmonary nodules are frequently not futile in patients with benign disease. J Thorac Oncol. 2011 Oct; 6(10): 1720-5. PMID: 21760552, PMCID: PMC3712870, DOI: 10.1097/JTO.0b013e318226b48a, ISSN: 1556-1380.

Deppen S, Putnam JB, Andrade G, Speroff T, Nesbitt JC, Lambright ES, Massion PP, Walker R, Grogan EL. Accuracy of FDG-PET to diagnose lung cancer in a region of endemic granulomatous disease. Ann. Thorac. Surg [print-electronic]. 2011 Aug; 92(2): 428-32; discussion 433. PMID: 21592456, PMCID: PMC3186439, PII: S0003-4975(11)00478-4, DOI: 10.1016/j.athoracsur.2011.02.052, ISSN: 1552-6259.

Callison JC, Walker RC, Massion PP. Somatostatin Receptors in Lung Cancer: From Function to Molecular Imaging and Therapeutics. J Lung Cancer. 2011; 10(2): 69-76. PMID: 25663834, PMCID: PMC4319675, DOI: 10.6058/jlc.2011.10.2.69, ISSN: 1598-7809.

Bartel TB, Haessler J, Brown TL, Shaughnessy JD, van Rhee F, Anaissie E, Alpe T, Angtuaco E, Walker R, Epstein J, Crowley J, Barlogie B. F18-fluorodeoxyglucose positron emission tomography in the context of other imaging techniques and prognostic factors in multiple myeloma. Blood [print-electronic]. 2009 Sep 9/3/2009; 114(10): 2068-76. PMID: 19443657, PMCID: PMC2744568, PII: blood-2009-03-213280, DOI: 10.1182/blood-2009-03-213280, ISSN: 1528-0020.

Walker RC, Jones-Jackson LB, Martin W, Habibian MR, Delbeke D. New imaging tools for the diagnosis of infection. Future Microbiol. 2007 Oct; 2(5): 527-54. PMID: 17927475, DOI: 10.2217/17460913.2.5.527, ISSN: 1746-0921.

King DL, Stack BC, Spring PM, Walker R, Bodenner DL. Incidence of thyroid carcinoma in fluorodeoxyglucose positron emission tomography-positive thyroid incidentalomas. Otolaryngol Head Neck Surg. 2007 Sep; 137(3): 400-4. PMID: 17765765, PII: S0194-5998(07)00230-6, DOI: 10.1016/j.otohns.2007.02.037, ISSN: 0194-5998.

Walker R, Barlogie B, Haessler J, Tricot G, Anaissie E, Shaughnessy JD, Epstein J, van Hemert R, Erdem E, Hoering A, Crowley J, Ferris E, Hollmig K, van Rhee F, Zangari M, Pineda-Roman M, Mohiuddin A, Yaccoby S, Sawyer J, Angtuaco EJ. Magnetic resonance imaging in multiple myeloma: diagnostic and clinical implications. J. Clin. Oncol [print-electronic]. 2007 Mar 3/20/2007; 25(9): 1121-8. PMID: 17296972, PII: JCO.2006.08.5803, DOI: 10.1200/JCO.2006.08.5803, ISSN: 1527-7755.

Shaughnessy JD, Zhan F, Burington BE, Huang Y, Colla S, Hanamura I, Stewart JP, Kordsmeier B, Randolph C, Williams DR, Xiao Y, Xu H, Epstein J, Anaissie E, Krishna SG, Cottler-Fox M, Hollmig K, Mohiuddin A, Pineda-Roman M, Tricot G, van Rhee F, Sawyer J, Alsayed Y, Walker R, Zangari M, Crowley J, Barlogie B. A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1. Blood [print-electronic]. 2007 Mar 3/15/2007; 109(6): 2276-84. PMID: 17105813, PII: blood-2006-07-038430, DOI: 10.1182/blood-2006-07-038430, ISSN: 0006-4971.

Yaccoby S, Ling W, Zhan F, Walker R, Barlogie B, Shaughnessy JD. Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood [print-electronic]. 2007 Mar 3/1/2007; 109(5): 2106-11. PMID: 17068150, PMCID: PMC1801040, PII: blood-2006-09-047712, DOI: 10.1182/blood-2006-09-047712, ISSN: 0006-4971.

Mahfouz T, Miceli MH, Saghafifar F, Stroud S, Jones-Jackson L, Walker R, et al.. 18F-fluorodeoxyglucose positron emission tomography contributes to the diagnosis and management of infections in patients with multiple myeloma: a study of 165 infectious episodes. Journal of Clinical Oncology. 2005; ((23)): 7857-63.

Maxwell C, Rasmussen E, Zhan F, Keats J, Adamia S, Strachan E, Crainie M, Walker, R, et al.. RHAMM expression and isoform balance predicts aggressive disease and poor survival in multiple myeloma. Blood. 2004; ((104)): 1151-8.

Barlogie B, Shaughnessy J, Tricot G, Jacobson J, Zangari M, Anaissie E, Walker R, Crowley J. Treatment of multiple myeloma. Blood. 2004; ((103)): 20-32.

Angtuaco EJC, Fassas AB, Walker RC, Sethi R, Barlogie B. Multiple myeloma: clinical review and diagnostic imaging. Radiology. 2004; ((231)): 11-23.

Miceli MH, Atoui R, Walker R, et al.. Diagnosis of deep septic thrombophlebitis in cancer patients by Fluorine-18 fluorodeoxyglucose positron emission tomography scanning: a preliminary report. Journal of Clinical Oncology. 2004; ((22)): 1949-56.

Walker RC, Zigler SS. PET practice in nuclear pharmacy. Journal American Pharmacists Association. 2003; ((32)).

Walker RC, Barlogie B, Shaughnessy J. Letter to the Editor regarding N Eng J Med 349:2483-2494, 2003 [letter]. New England Journal of Medicine. 2003; 14((350)): 1465.

Tian E, Zhan F, Walker R, et al.. The role of the Wn/β-catenin signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. New England Journal of Medicine. 2003; ((349)): 2483-94.

Walker RC, Weiss DW, Purnell GL, Forte KF. Positron emisson tomography scanning: a primer. Journal of the Arkansas Medical Society. 2002; 4((99)): 119-21.