Aaron B. Bowman, Ph.D.

Associate Professor

aaron.bowman@vanderbilt.edu

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Faculty Appointments
Associate Professor of Pediatrics Associate Professor of BiochemistryAssociate Professor of Neurology
Education
Ph.D., Biomedical Sciences, University of California, San Diego, CaliforniaB.S., Microbiology, Brigham Young University, Provo, Utah
Office Address
VUMC Pediatric Neurology Research Lab
1161 21st Avenue South
D-4108A, MCN Mail Code: 2594
Nashville, TN 37232
Research Description
My lab utilizes a combined approach of molecular genetics, pharmacology, biochemistry, cell and developmental biology to understand the role of gene-environment interactions between metal exposure and neurological disease such as Huntington's disease (HD), Parkinson's disease (PD), neurodevelopmental toxicity and restless legs syndrome. We employ a diverse range of model systems including patient-derived induced pluripotent stem cells (iPSCs), neuronal cultures and mouse models. We aim to define mechanisms of neuronal dysfunction and understand the basis of selective neuropathology, by characterizing the molecular function of disease genes and their interaction with environmental toxicants under both normal and pathological conditions. My lab has established protocols to generate iPSC lines and differentiate them down cortical, striatal and midbrain neural lineages. We have developed techniques to examine toxicological and neurodegenerative/neurological related phenotypes in this patient-specific model system. In addition, we have utilized a novel high-throughput screening method to find small molecule modifiers of cellular manganese status. Recently, our work has implicated specific cellular signaling systems (e.g. p53, AKT, mTOR pathways) underlying the influence of manganese on energetics and cellular metabolism in the context of the neurological diseases we study. My labs long-term goals are to determine patient-specific and disease-specific toxicant vulnerabilities, understand the cellular pathways underlying these gene-environment interactions and develop neuroprotective strategies to mitigate neurological diseases with environmental etiologies.
Research Keywords
Gene-environment interactions underlying neurological disease using human and mouse models
Publications
Tidball AM, Neely MD, Chamberlin R, Aboud AA, Kumar KK, Han B, Bryan MR, Aschner M, Ess KC, Bowman AB. Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells. PLoS ONE. 2016; 11(3): e0150372. PMID: 26982737, PMCID: PMC4794230, PII: PONE-D-15-19601, DOI: 10.1371/journal.pone.0150372, ISSN: 1932-6203.

Pancani T, Foster DJ, Moehle MS, Bichell TJ, Bradley E, Bridges TM, Klar R, Poslusney M, Rook JM, Daniels JS, Niswender CM, Jones CK, Wood MR, Bowman AB, Lindsley CW, Xiang Z, Conn PJ. Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2015 Nov 11/10/2015; 112(45): 14078-83. PMID: 26508634, PMCID: PMC4653197, PII: 1512812112, DOI: 10.1073/pnas.1512812112, ISSN: 1091-6490.

Chun YW, Balikov DA, Feaster TK, Williams CH, Sheng CC, Lee JB, Boire TC, Neely MD, Bellan LM, Ess KC, Bowman AB, Sung HJ, Hong CC. Combinatorial polymer matrices enhance in vitro maturation of human induced pluripotent stem cell-derived cardiomyocytes. Biomaterials [print-electronic]. 2015 Oct; 67: 52-64. PMID: 26204225, PMCID: PMC4550551, PII: S0142-9612(15)00580-3, DOI: 10.1016/j.biomaterials.2015.07.004, ISSN: 1878-5905.

Brown JA, Pensabene V, Markov DA, Allwardt V, Neely MD, Shi M, Britt CM, Hoilett OS, Yang Q, Brewer BM, Samson PC, McCawley LJ, May JM, Webb DJ, Li D, Bowman AB, Reiserer RS, Wikswo JP. Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor. Biomicrofluidics. 2015 Sep; 9(5): 54124. PMID: 26576206, PMCID: PMC4627929, PII: 024505BMF, PII: 1.4934713, DOI: 10.1063/1.4934713, ISSN: 1932-1058.

Chen P, Chakraborty S, Mukhopadhyay S, Lee E, Paoliello MM, Bowman AB, Aschner M. Manganese homeostasis in the nervous system. J. Neurochem [print-electronic]. 2015 Aug; 134(4): 601-10. PMID: 25982296, PMCID: PMC4516557, DOI: 10.1111/jnc.13170, ISSN: 1471-4159.

Chen P, Bowman AB, Mukhopadhyay S, Aschner M. SLC30A10: A novel manganese transporter. Worm. 2015 Jul; 4(3): e1042648. PMID: 26430566, PMCID: PMC4588552, PII: 1042648, DOI: 10.1080/21624054.2015.1042648, ISSN: 2162-4046.

Kwakye GF, Paoliello MM, Mukhopadhyay S, Bowman AB, Aschner M. Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features. Int J Environ Res Public Health. 2015 Jul; 12(7): 7519-40. PMID: 26154659, PMCID: PMC4515672, PII: ijerph120707519, DOI: 10.3390/ijerph120707519, ISSN: 1660-4601.

Chakraborty S, Chen P, Bornhorst J, Schwerdtle T, Schumacher F, Kleuser B, Bowman AB, Aschner M. Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans. Metallomics [print-electronic]. 2015 May; 7(5): 847-56. PMID: 25769119, PMCID: PMC4431931, DOI: 10.1039/c5mt00052a, ISSN: 1756-591X.

Tidball AM, Bryan MR, Uhouse MA, Kumar KK, Aboud AA, Feist JE, Ess KC, Neely MD, Aschner M, Bowman AB. A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease. Hum. Mol. Genet [print-electronic]. 2015 Apr 4/1/2015; 24(7): 1929-44. PMID: 25489053, PMCID: PMC4355025, PII: ddu609, DOI: 10.1093/hmg/ddu609, ISSN: 1460-2083.

Chen P, Chakraborty S, Peres TV, Bowman AB, Aschner M. Manganese-induced Neurotoxicity: From C. elegans to Humans. Toxicol Res (Camb). 2015 Mar 3/1/2015; 4(2): 191-202. PMID: 25893090, PMCID: PMC4399965, DOI: 10.1039/C4TX00127C, ISSN: 2045-452X.

Kumar KK, Goodwin CR, Uhouse MA, Bornhorst J, Schwerdtle T, Aschner M, McLean JA, Bowman AB. Untargeted metabolic profiling identifies interactions between Huntington's disease and neuronal manganese status. Metallomics. 2015 Feb; 7(2): 363-70. PMID: 25599126, PMCID: PMC4326616, DOI: 10.1039/c4mt00223g, ISSN: 1756-591X.

Chen P, DeWitt MR, Bornhorst J, Soares FA, Mukhopadhyay S, Bowman AB, Aschner M. Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease. Metallomics. 2015 Feb; 7(2): 289-98. PMID: 25531510, PMCID: PMC4479152, DOI: 10.1039/c4mt00292j, ISSN: 1756-591X.

Aboud AA, Tidball AM, Kumar KK, Neely MD, Han B, Ess KC, Hong CC, Erikson KM, Hedera P, Bowman AB. PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper. Neurobiol. Dis [print-electronic]. 2015 Jan; 73: 204-12. PMID: 25315681, PMCID: PMC4394022, PII: S0969-9961(14)00295-2, DOI: 10.1016/j.nbd.2014.10.002, ISSN: 1095-953X.

Parmalee NL, Maqbool SB, Ye B, Calder B, Bowman AB, Aschner M. RNASeq in C. elegans Following Manganese Exposure. Curr Protoc Toxicol. 2015; 65: 11.20.1-17. PMID: 26250396, PMCID: PMC4539565, DOI: 10.1002/0471140856.tx1120s65, ISSN: 1934-9262.

Horning KJ, Caito SW, Tipps KG, Bowman AB, Aschner M. Manganese Is Essential for Neuronal Health. Annu. Rev. Nutr [print-electronic]. 2015; 35: 71-108. PMID: 25974698, DOI: 10.1146/annurev-nutr-071714-034419, ISSN: 1545-4312.

Stansfield KH, Bichell TJ, Bowman AB, Guilarte TR. BDNF and Huntingtin protein modifications by manganese: implications for striatal medium spiny neuron pathology in manganese neurotoxicity. J. Neurochem [print-electronic]. 2014 Dec; 131(5): 655-66. PMID: 25099302, PMCID: PMC4296578, DOI: 10.1111/jnc.12926, ISSN: 1471-4159.

Leyva-Illades D, Chen P, Zogzas CE, Hutchens S, Mercado JM, Swaim CD, Morrisett RA, Bowman AB, Aschner M, Mukhopadhyay S. SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity. J. Neurosci. 2014 Oct 10/15/2014; 34(42): 14079-95. PMID: 25319704, PMCID: PMC4198546, PII: 34/42/14079, DOI: 10.1523/JNEUROSCI.2329-14.2014, ISSN: 1529-2401.

West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM. Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension. Am. J. Physiol., Cell Physiol [print-electronic]. 2014 Sep 9/1/2014; 307(5): C415-30. PMID: 24871858, PMCID: PMC4154073, PII: ajpcell.00057.2014, DOI: 10.1152/ajpcell.00057.2014, ISSN: 1522-1563.

Bowman AB, Aschner M. Considerations on manganese (Mn) treatments for in vitro studies. Neurotoxicology [print-electronic]. 2014 Mar; 41: 141-2. PMID: 24509086, PMCID: PMC4004588, PII: S0161-813X(14)00023-0, DOI: 10.1016/j.neuro.2014.01.010, ISSN: 1872-9711.

Bornhorst J, Chakraborty S, Meyer S, Lohren H, Brinkhaus SG, Knight AL, Caldwell KA, Caldwell GA, Karst U, Schwerdtle T, Bowman A, Aschner M. The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of a-synuclein in C. elegans. Metallomics [print-electronic]. 2014 Mar; 6(3): 476-90. PMID: 24452053, PMCID: PMC3954834, DOI: 10.1039/c3mt00325f, ISSN: 1756-591X.

Kumar KK, Lowe EW, Aboud AA, Neely MD, Redha R, Bauer JA, Odak M, Weaver CD, Meiler J, Aschner M, Bowman AB. Cellular manganese content is developmentally regulated in human dopaminergic neurons. Sci Rep. 2014; 4: 6801. PMID: 25348053, PMCID: PMC4210885, PII: srep06801, DOI: 10.1038/srep06801, ISSN: 2045-2322.

Srinivasakumar N, Zaboikin M, Tidball AM, Aboud AA, Neely MD, Ess KC, Bowman AB, Schuening FG. Gammaretroviral vector encoding a fluorescent marker to facilitate detection of reprogrammed human fibroblasts during iPSC generation. PeerJ. 2013; 1: e224. PMID: 24392288, PMCID: PMC3869187, PII: 224, DOI: 10.7717/peerj.224, ISSN: 2167-8359.

Kumar KK, Aboud AA, Patel DK, Aschner M, Bowman AB. Optimization of fluorescence assay of cellular manganese status for high throughput screening. J. Biochem. Mol. Toxicol [print-electronic]. 2013 Jan; 27(1): 42-9. PMID: 23169769, PMCID: PMC3774111, DOI: 10.1002/jbt.21457, ISSN: 1099-0461.

Aboud AA, Tidball AM, Kumar KK, Neely MD, Ess KC, Erikson KM, Bowman AB. Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects. Neurotoxicology [print-electronic]. 2012 Dec; 33(6): 1443-9. PMID: 23099318, PMCID: PMC3518601, PII: S0161-813X(12)00252-5, DOI: 10.1016/j.neuro.2012.10.009, ISSN: 1872-9711.

Neely MD, Litt MJ, Tidball AM, Li GG, Aboud AA, Hopkins CR, Chamberlin R, Hong CC, Ess KC, Bowman AB. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS Chem Neurosci [print-electronic]. 2012 Jun 6/20/2012; 3(6): 482-91. PMID: 22860217, PMCID: PMC3400384, DOI: 10.1021/cn300029t, ISSN: 1948-7193.

Kumar KK, Aboud AA, Bowman AB. The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk. Neurotoxicology [print-electronic]. 2012 Jun; 33(3): 518-29. PMID: 22330734, PMCID: PMC3358591, PII: S0161-813X(12)00039-3, DOI: 10.1016/j.neuro.2012.02.005, ISSN: 1872-9711.

Xu L, Mirnics K, Bowman AB, Liu W, Da J, Porter NA, Korade Z. DHCEO accumulation is a critical mediator of pathophysiology in a Smith-Lemli-Opitz syndrome model. Neurobiol. Dis [print-electronic]. 2012 Mar; 45(3): 923-9. PMID: 22182693, PMCID: PMC3674775, PII: S0969-9961(11)00386-X, DOI: 10.1016/j.nbd.2011.12.011, ISSN: 1095-953X.

Wegrzynowicz M, Holt HK, Friedman DB, Bowman AB. Changes in the striatal proteome of YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganese. J. Proteome Res [print-electronic]. 2012 Feb 2/3/2012; 11(2): 1118-32. PMID: 22191580, PMCID: PMC3319668, DOI: 10.1021/pr200839d, ISSN: 1535-3907.

Madison JL, Wegrzynowicz M, Aschner M, Bowman AB. Disease-toxicant interactions in manganese exposed Huntington disease mice: early changes in striatal neuron morphology and dopamine metabolism. PLoS ONE [print-electronic]. 2012; 7(2): e31024. PMID: 22363539, PMCID: PMC3281892, PII: PONE-D-11-22066, DOI: 10.1371/journal.pone.0031024, ISSN: 1932-6203.

Bowman AB, Kwakye GF, Herrero Hernández E, Aschner M. Role of manganese in neurodegenerative diseases. J Trace Elem Med Biol [print-electronic]. 2011 Dec; 25(4): 191-203. PMID: 21963226, PMCID: PMC3230726, PII: S0946-672X(11)00233-1, DOI: 10.1016/j.jtemb.2011.08.144, ISSN: 1878-3252.

Madison JL, Wegrzynowicz M, Aschner M, Bowman AB. Gender and manganese exposure interactions on mouse striatal neuron morphology. Neurotoxicology [print-electronic]. 2011 Dec; 32(6): 896-906. PMID: 21641932, PMCID: PMC3169725, PII: S0161-813X(11)00096-9, DOI: 10.1016/j.neuro.2011.05.007, ISSN: 1872-9711.

Lee Y, Fryer JD, Kang H, Crespo-Barreto J, Bowman AB, Gao Y, Kahle JJ, Hong JS, Kheradmand F, Orr HT, Finegold MJ, Zoghbi HY. ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Dev. Cell. 2011 Oct 10/18/2011; 21(4): 746-57. PMID: 22014525, PMCID: PMC3253850, PII: S1534-5807(11)00355-8, DOI: 10.1016/j.devcel.2011.08.017, ISSN: 1878-1551.

Kwakye GF, Li D, Bowman AB. Novel high-throughput assay to assess cellular manganese levels in a striatal cell line model of Huntington's disease confirms a deficit in manganese accumulation. Neurotoxicology [print-electronic]. 2011 Oct; 32(5): 630-9. PMID: 21238486, PMCID: PMC3135664, PII: S0161-813X(11)00005-2, DOI: 10.1016/j.neuro.2011.01.002, ISSN: 1872-9711.

Kwakye GF, Li D, Kabobel OA, Bowman AB. Cellular fura-2 manganese extraction assay (CFMEA). Curr Protoc Toxicol. 2011 May; Chapter 12: Unit12.18. PMID: 21553393, PMCID: PMC3661216, DOI: 10.1002/0471140856.tx1218s48, ISSN: 1934-9262.

Grover VK, Valadez JG, Bowman AB, Cooper MK. Lipid modifications of Sonic hedgehog ligand dictate cellular reception and signal response. PLoS ONE [print-electronic]. 2011; 6(7): e21353. PMID: 21747935, PMCID: PMC3128587, PII: PONE-D-10-03118, DOI: 10.1371/journal.pone.0021353, ISSN: 1932-6203.

Sidoryk-Wegrzynowicz M, Wegrzynowicz M, Lee E, Bowman AB, Aschner M. Role of astrocytes in brain function and disease. Toxicol Pathol [print-electronic]. 2011 Jan; 39(1): 115-23. PMID: 21075920, PII: 0192623310385254, DOI: 10.1177/0192623310385254, ISSN: 1533-1601.

Williams BB, Kwakye GF, Wegrzynowicz M, Li D, Aschner M, Erikson KM, Bowman AB. Altered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system. Toxicol. Sci [print-electronic]. 2010 Sep; 117(1): 169-79. PMID: 20547568, PMCID: PMC2923282, PII: kfq174, DOI: 10.1093/toxsci/kfq174, ISSN: 1096-0929.

Yin Z, Jiang H, Lee ES, Ni M, Erikson KM, Milatovic D, Bowman AB, Aschner M. Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation. J. Neurochem [print-electronic]. 2010 Mar; 112(5): 1190-8. PMID: 20002294, PMCID: PMC2819584, PII: JNC6534, DOI: 10.1111/j.1471-4159.2009.06534.x, ISSN: 1471-4159.

Milatovic D, Montine TJ, Zaja-Milatovic S, Madison JL, Bowman AB, Aschner M. Morphometric analysis in neurodegenerative disorders. Curr Protoc Toxicol. 2010 Feb; Chapter 12: Unit 12.16. PMID: 20401325, PMCID: PMC2855147, DOI: 10.1002/0471140856.tx1216s43, ISSN: 1934-9262.

Williams BB, Li D, Wegrzynowicz M, Vadodaria BK, Anderson JG, Kwakye GF, Aschner M, Erikson KM, Bowman AB. Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposure. J. Neurochem [print-electronic]. 2010 Jan; 112(1): 227-37. PMID: 19845833, PMCID: PMC3083829, PII: JNC6445, DOI: 10.1111/j.1471-4159.2009.06445.x, ISSN: 1471-4159.

Halladay AK, Amaral D, Aschner M, Bolivar VJ, Bowman A, DiCicco-Bloom E, Hyman SL, Keller F, Lein P, Pessah I, Restifo L, Threadgill DW. Animal models of autism spectrum disorders: information for neurotoxicologists. Neurotoxicology [print-electronic]. 2009 Sep; 30(5): 811-21. PMID: 19596370, PMCID: PMC3014989, PII: S0161-813X(09)00136-3, DOI: 10.1016/j.neuro.2009.07.002, ISSN: 1872-9711.

Lim J, Crespo-Barreto J, Jafar-Nejad P, Bowman AB, Richman R, Hill DE, Orr HT, Zoghbi HY. Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Nature [print-electronic]. 2008 Apr 4/10/2008; 452(7188): 713-8. PMID: 18337722, PMCID: PMC2377396, PII: nature06731, DOI: 10.1038/nature06731, ISSN: 1476-4687.

Bowman AB, Lam YC, Jafar-Nejad P, Chen HK, Richman R, Samaco RC, Fryer JD, Kahle JJ, Orr HT, Zoghbi HY. Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes. Nat. Genet [print-electronic]. 2007 Mar; 39(3): 373-9. PMID: 17322884, PII: ng1977, DOI: 10.1038/ng1977, ISSN: 1061-4036.

Helmlinger D, Hardy S, Abou-Sleymane G, Eberlin A, Bowman AB, Gansm├╝ller A, Picaud S, Zoghbi HY, Trottier Y, Tora L, Devys D. Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction. PLoS Biol [print-electronic]. 2006 Mar; 4(3): e67. PMID: 16494529, PMCID: PMC1382020, PII: 05-PLBI-RA-0523R4, DOI: 10.1371/journal.pbio.0040067, ISSN: 1545-7885.

*Lam YC, *Bowman AB, Jafar-Nejad P, Lim J, Richman R, Fryer JD, Hyun ED, Duvick LA, Orr HT, Botas J, Zoghbi HY (* denotes co-first authorship). ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology. 2006.

Young JI, Hong EP, Castle JC, Crespo-Barreto J, Bowman AB, Rose MF, Kang D, Richman R, Johnson JM, Berget S, Zoghbi HY. Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2005 Dec 12/6/2005; 102(49): 17551-8. PMID: 16251272, PMCID: PMC1266160, PII: 0507856102, DOI: 10.1073/pnas.0507856102, ISSN: 0027-8424.

Bowman AB, Yoo SY, Dantuma NP, Zoghbi HY. Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation. Hum. Mol. Genet [print-electronic]. 2005 Mar 3/1/2005; 14(5): 679-91. PMID: 15661755, PII: ddi064, DOI: 10.1093/hmg/ddi064, ISSN: 0964-6906.

Bowman AB, Levorse JM, Ingram RS, Tilghman SM. Functional characterization of a testis-specific DNA binding activity at the H19/Igf2 imprinting control region. Mol. Cell. Biol. 2003 Nov; 23(22): 8345-51. PMID: 14585991, PMCID: PMC262389, ISSN: 0270-7306.

Bowman AB and Goldstein LSB. ENCYCLOPEDIA OF LIFE SCIENCES. [place unknown: publisher unknown]; 2001. (John Wiley & Sons, Ltd: Chichester. http://www.els.net/).

Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS. Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein. Cell. 2000 Nov 11/10/2000; 103(4): 583-94. PMID: 11106729, PII: S0092-8674(00)00162-8, ISSN: 0092-8674.

Bowman AB, Patel-King RS, Benashski SE, McCaffery JM, Goldstein LS, King SM. Drosophila roadblock and Chlamydomonas LC7: a conserved family of dynein-associated proteins involved in axonal transport, flagellar motility, and mitosis. J. Cell Biol. 1999 Jul 7/12/1999; 146(1): 165-80. PMID: 10402468, PMCID: PMC2199740, ISSN: 0021-9525.

Available Postdoctoral Position Details
Posted: 11/9/2015
2015-2016; Recruiting an enthusiastic well-trained postdoctoral fellow. Send CV and references to Aaron Bowman (aaron.bowman@vanderbilt.edu). Preference will be given to NIH training grant eligible applicants (US citizen or green card holder). Minority applicants encouraged.