Brian G. Engelhardt, M.D.

Associate Professor

brian.engelhardt@vanderbilt.edu
Faculty Appointments
Associate Professor of Medicine
Education
M.S.C.I., Clinical Investigation , Vanderbilt University, Nashville, TennesseeM.D., MEDICINE, Case Western Reserve University, Cleveland, OhioB.S., University of Michigan, Dearborn, Michigan
Office Address
2665 TVC
Nashville, TN 37232-5505
Publications
Das-Gupta E, Greinix H, Jacobs R, Zhou L, Savani BN, Engelhardt BG, Kassim A, Worel N, Knobler R, Russell N, Jagasia M. Extracorporeal photopheresis as second-line treatment for acute graft-versus-host disease: impact on six-month freedom from treatment failure. Haematologica [print-electronic]. 2014 Nov; 99(11): 1746-52. PMID: 25150260, PMCID: PMC4222474, PII: haematol.2014.108217, DOI: 10.3324/haematol.2014.108217, ISSN: 1592-8721.

Sengsayadeth S, Savani BN, Jagasia M, Goodman S, Greer JP, Chen H, Chinratanalab W, Kassim AA, Engelhardt BG. Six-month freedom from treatment failure is an important end point for acute GVHD clinical trials. Bone Marrow Transplant [print-electronic]. 2014 Feb; 49(2): 236-40. PMID: 24096824, PMCID: PMC3946331, PII: bmt2013157, DOI: 10.1038/bmt.2013.157, ISSN: 1476-5365.

Ragon BK, Clifton C, Chen H, Savani BN, Engelhardt BG, Kassim AA, Vaughan LA, Lucid C, Jagasia M. Geographic distance is not associated with inferior outcome when using long-term transplant clinic strategy. Biol. Blood Marrow Transplant [print-electronic]. 2014 Jan; 20(1): 53-7. PMID: 24120525, PII: S1083-8791(13)00450-3, DOI: 10.1016/j.bbmt.2013.10.004, ISSN: 1523-6536.

Reddy NM, Oluwole O, Greer JP, Engelhardt BG, Jagasia MH, Savani BN. Outcomes of autologous or allogeneic stem cell transplantation for non-Hodgkin lymphoma. Exp. Hematol [print-electronic]. 2014 Jan; 42(1): 39-45. PMID: 24096123, PII: S0301-472X(13)00747-9, DOI: 10.1016/j.exphem.2013.09.012, ISSN: 1873-2399.

Vaughan LA, Vu M, Sengsayadeth S, Lucid C, Clifton C, McCarty K, Hagaman D, Domm J, Kassim A, Chinratanalab W, Goodman S, Greer J, Frangoul H, Engelhardt BG, Jagasia M, Savani BN. New allergies after cord blood transplantation. Cytotherapy. 2013 Oct; 15(10): 1259-65. PMID: 23993300, PII: S1465-3249(13)00550-1, DOI: 10.1016/j.jcyt.2013.05.018, ISSN: 1477-2566.

Jagasia M, Greinix H, Robin M, Das-Gupta E, Jacobs R, Savani BN, Engelhardt BG, Kassim A, Worel N, Knobler R, Russell N, Socie G. Extracorporeal photopheresis versus anticytokine therapy as a second-line treatment for steroid-refractory acute GVHD: a multicenter comparative analysis. Biol. Blood Marrow Transplant [print-electronic]. 2013 Jul; 19(7): 1129-33. PMID: 23623892, PII: S1083-8791(13)00186-9, DOI: 10.1016/j.bbmt.2013.04.018, ISSN: 1523-6536.

Weitkamp JH, Koyama T, Rock MT, Correa H, Goettel JA, Matta P, Oswald-Richter K, Rosen MJ, Engelhardt BG, Moore DJ, Polk DB. Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios. Gut [print-electronic]. 2013 Jan; 62(1): 73-82. PMID: 22267598, PMCID: PMC3606820, PII: gutjnl-2011-301551, DOI: 10.1136/gutjnl-2011-301551, ISSN: 1468-3288.

Engelhardt BG, Sengsayadeth SM, Jagasia M, Savani BN, Kassim AA, Lu P, Shyr Y, Yoder SM, Rock MT, Crowe JE. Tissue-specific regulatory T cells: biomarker for acute graft-vs-host disease and survival. Exp. Hematol [print-electronic]. 2012 Dec; 40(12): 974-982.e1. PMID: 22885125, PMCID: PMC3611587, PII: S0301-472X(12)00343-8, DOI: 10.1016/j.exphem.2012.08.002, ISSN: 1873-2399.

Sengsayadeth SM, Jagasia M, Engelhardt BG, Kassim A, Strickland SA, Goodman S, Lucid C, Vnencak-Jones CL, Greer JP, Savani BN. Allo-SCT for high-risk AML-CR1 in the molecular era: impact of FLT3/ITD outweighs the conventional markers. Bone Marrow Transplant [print-electronic]. 2012 Dec; 47(12): 1535-7. PMID: 22659680, PII: bmt201288, DOI: 10.1038/bmt.2012.88, ISSN: 1476-5365.

Jacobs R, Tran U, Chen H, Kassim A, Engelhardt BG, Greer JP, Goodman SG, Clifton C, Lucid C, Vaughan LA, Savani BN, Jagasia M. Prevalence and risk factors associated with development of ocular GVHD defined by NIH consensus criteria. Bone Marrow Transplant [print-electronic]. 2012 Nov; 47(11): 1470-3. PMID: 22484321, PII: bmt201256, DOI: 10.1038/bmt.2012.56, ISSN: 1476-5365.

Jagasia M, Clark WB, Brown-Gentry KD, Crawford DC, Fan KH, Chen H, Kassim A, Greer JP, Engelhardt BG, Savani BN. Genetic variation in donor CTLA-4 regulatory region is a strong predictor of outcome after allogeneic hematopoietic cell transplantation for hematologic malignancies. Biol. Blood Marrow Transplant [print-electronic]. 2012 Jul; 18(7): 1069-75. PMID: 22178694, PII: S1083-8791(11)01080-9, DOI: 10.1016/j.bbmt.2011.12.518, ISSN: 1523-6536.

Engelhardt BG, Jagasia SM, Crowe JE, Griffith ML, Savani BN, Kassim AA, Lu P, Weitkamp JH, Moore DJ, Yoder SM, Rock MT, Jagasia M. Predicting posttransplantation diabetes mellitus by regulatory T-cell phenotype: implications for metabolic intervention to modulate alloreactivity. Blood [print-electronic]. 2012 Mar 3/8/2012; 119(10): 2417-21. PMID: 22262764, PMCID: PMC3311262, PII: blood-2011-10-384750, DOI: 10.1182/blood-2011-10-384750, ISSN: 1528-0020.

Clark WB, Brown-Gentry KD, Crawford DC, Fan KH, Snavely J, Chen H, Savani BN, Kassim A, Greer JP, Schuening FG, Engelhardt BG, Jagasia MH. Genetic variation in recipient B-cell activating factor modulates phenotype of GVHD. Blood [print-electronic]. 2011 Jul 7/28/2011; 118(4): 1140-4. PMID: 21628416, PII: blood-2010-09-310011, DOI: 10.1182/blood-2010-09-310011, ISSN: 1528-0020.

Lucid CE, Savani BN, Engelhardt BG, Shah P, Clifton C, Greenhut SL, Vaughan LA, Kassim A, Schuening F, Jagasia M. Extracorporeal photopheresis in patients with refractory bronchiolitis obliterans developing after allo-SCT. Bone Marrow Transplant [print-electronic]. 2011 Mar; 46(3): 426-9. PMID: 20581885, PII: bmt2010152, DOI: 10.1038/bmt.2010.152, ISSN: 1476-5365.

Engelhardt BG, Jagasia M, Savani BN, Bratcher NL, Greer JP, Jiang A, Kassim AA, Lu P, Schuening F, Yoder SM, Rock MT, Crowe JE. Regulatory T cell expression of CLA or a(4)ß(7) and skin or gut acute GVHD outcomes. Bone Marrow Transplant [print-electronic]. 2011 Mar; 46(3): 436-42. PMID: 20577222, PMCID: PMC3217583, PII: bmt2010127, DOI: 10.1038/bmt.2010.127, ISSN: 1476-5365.

Tedeschi SK, Jagasia M, Engelhardt BG, Domm J, Kassim AA, Chinratanalab W, Greenhut SL, Goodman S, Greer JP, Schuening F, Frangoul H, Savani BN. Early lymphocyte reconstitution is associated with improved transplant outcome after cord blood transplantation. Cytotherapy [print-electronic]. 2011 Jan; 13(1): 78-82. PMID: 20586668, DOI: 10.3109/14653249.2010.495114, ISSN: 1477-2566.

Griffith ML, Jagasia MH, Misfeldt AA, Chen H, Engelhardt BG, Kassim A, Savani BN, Survant M, Jagasia SM. Pretransplantation C-Peptide level predicts early posttransplantation diabetes mellitus and has an impact on survival after allogeneic stem cell transplantation. Biol. Blood Marrow Transplant [print-electronic]. 2011 Jan; 17(1): 86-92. PMID: 20561594, PII: S1083-8791(10)00254-5, DOI: 10.1016/j.bbmt.2010.06.010, ISSN: 1523-6536.

Engelhardt BG, Crowe JE. Homing in on acute graft vs. host disease: tissue-specific T regulatory and Th17 cells. Curr. Top. Microbiol. Immunol. 2010; 341: 121-46. PMID: 20563712, PMCID: PMC3793903, DOI: 10.1007/82_2010_24, ISSN: 0070-217X.

Engelhardt BG, Holland DW, Brandt SJ, Chinratanalab W, Goodman SA, Greer JP, Jagasia MH, Kassim AA, Morgan DS, Ruffner KL, Schuening FG, Wolff S, Bitting R, Sulur P, Stein RS. High-dose chemotherapy followed by autologous stem cell transplantation for relapsed or refractory Hodgkin lymphoma: prognostic features and outcomes. Leuk. Lymphoma. 2007 Sep; 48(9): 1728-35. PMID: 17786708, PII: 781802102, DOI: 10.1080/10428190701534374, ISSN: 1042-8194.