Dineo Khabele, M.D.

Associate Professor

Faculty Appointments
Associate Professor of Obstetrics and Gynecology Associate Professor of Cancer Biology
M.D., Columbia University, New York, New YorkB.A., Columbia University, New York, New York
Office Address
1161 21st Ave South
Nashville, TN 37232
Research Description
Dr. Khabele conducts translational and clinical research studies in gynecologic oncology. The primary goal of the translational research program is to design personalized diagnostics and therapeutics (based on genetic and epigenetic alterations in DNA damage response, inflammatory, and cell death pathways) as molecular targets for ovarian cancer.
Research Keywords
Gynecologic Oncology Translational Research
Clinical Research Keywords
Gynecologic Oncology
Desouki MM, Khabele D, Crispens MA, Fadare O. Ovarian mucinous tumor with malignant mural nodules: dedifferentiation or collision?. Int. J. Gynecol. Pathol. 2015 Jan; 34(1): 19-24. PMID: 25473748, DOI: 10.1097/PGP.0000000000000105, ISSN: 1538-7151.

Konstantinopoulos PA, Wilson AJ, Saskowski J, Wass E, Khabele D. Suberoylanilide hydroxamic acid (SAHA) enhances olaparib activity by targeting homologous recombination DNA repair in ovarian cancer. Gynecol. Oncol [print-electronic]. 2014 Jun; 133(3): 599-606. PMID: 24631446, PMCID: PMC4347923, PII: S0090-8258(14)00239-X, DOI: 10.1016/j.ygyno.2014.03.007, ISSN: 1095-6859.

Desouki MM, Kallas SJ, Khabele D, Crispens MA, Hameed O, Fadare O. Differential vimentin expression in ovarian and uterine corpus endometrioid adenocarcinomas: diagnostic utility in distinguishing double primaries from metastatic tumors. Int. J. Gynecol. Pathol. 2014 May; 33(3): 274-81. PMID: 24681739, PMCID: PMC4144715, DOI: 10.1097/PGP.0b013e31829040b5, ISSN: 1538-7151.

Collins Y, Holcomb K, Chapman-Davis E, Khabele D, Farley JH. Gynecologic cancer disparities: a report from the Health Disparities Taskforce of the Society of Gynecologic Oncology. Gynecol. Oncol [print-electronic]. 2014 May; 133(2): 353-61. PMID: 24406291, PMCID: PMC4079541, PII: S0090-8258(14)00002-X, DOI: 10.1016/j.ygyno.2013.12.039, ISSN: 1095-6859.

Hull PC, Williams EA, Khabele D, Dean C, Bond B, Sanderson M. HPV vaccine use among African American girls: qualitative formative research using a participatory social marketing approach. Gynecol. Oncol [print-electronic]. 2014 Mar; 132 Suppl 1: S13-20. PMID: 24491412, PMCID: PMC3966189, PII: S0090-8258(14)00106-1, DOI: 10.1016/j.ygyno.2014.01.046, ISSN: 1095-6859.

Khabele D, Kabir SM, Dong Y, Lee E, Rice VM, Son DS. Preferential effect of akt2-dependent signaling on the cellular viability of ovarian cancer cells in response to EGF. J Cancer. 2014; 5(8): 670-8. PMID: 25258648, PMCID: PMC4174511, PII: jcav05p0670, DOI: 10.7150/jca.9688, ISSN: 1837-9664.

Khabele D. The therapeutic potential of class I selective histone deacetylase inhibitors in ovarian cancer. Front Oncol. 2014; 4: 111. PMID: 24904826, PMCID: PMC4033132, DOI: 10.3389/fonc.2014.00111, ISSN: 2234-943X.

Fadare O, James S, Desouki MM, Khabele D. Coordinate patterns of estrogen receptor, progesterone receptor, and Wilms tumor 1 expression in the histopathologic distinction of ovarian from endometrial serous adenocarcinomas. Ann Diagn Pathol [print-electronic]. 2013 Oct; 17(5): 430-3. PMID: 23706170, PMCID: PMC4079538, PII: S1092-9134(13)00036-1, DOI: 10.1016/j.anndiagpath.2013.04.011, ISSN: 1532-8198.

Wilson AJ, Liu AY, Roland J, Adebayo OB, Fletcher SA, Slaughter JC, Saskowski J, Crispens MA, Jones HW, James S, Fadare O, Khabele D. TR3 modulates platinum resistance in ovarian cancer. Cancer Res [print-electronic]. 2013 Aug 8/1/2013; 73(15): 4758-69. PMID: 23720056, PMCID: PMC3944084, PII: 0008-5472.CAN-12-4560, DOI: 10.1158/0008-5472.CAN-12-4560, ISSN: 1538-7445.

Fadare O, Gwin K, Desouki MM, Crispens MA, Jones HW, Khabele D, Liang SX, Zheng W, Mohammed K, Hecht JL, Parkash V. The clinicopathologic significance of p53 and BAF-250a (ARID1A) expression in clear cell carcinoma of the endometrium. Mod. Pathol [print-electronic]. 2013 Aug; 26(8): 1101-10. PMID: 23524907, PMCID: PMC3886836, PII: modpathol201335, DOI: 10.1038/modpathol.2013.35, ISSN: 1530-0285.

Fadare O, Liang SX, Crispens MA, Jones HW, Khabele D, Gwin K, Zheng W, Mohammed K, Parkash V, Hecht JL, Desouki MM. Expression of the oncofetal protein IGF2BP3 in endometrial clear cell carcinoma: assessment of frequency and significance. Hum. Pathol [print-electronic]. 2013 Aug; 44(8): 1508-15. PMID: 23465280, PMCID: PMC3888088, PII: S0046-8177(12)00451-0, DOI: 10.1016/j.humpath.2012.12.003, ISSN: 1532-8392.

Fadare O, Khabele D. Salpingo-oophorectomy specimens for endometrial cancer staging: a comparative analysis of representative sampling versus whole tissue processing. Hum. Pathol [print-electronic]. 2013 Apr; 44(4): 643-50. PMID: 23084582, PMCID: PMC4079536, PII: S0046-8177(12)00272-9, DOI: 10.1016/j.humpath.2012.07.015, ISSN: 1532-8392.

Wilson AJ, Barham W, Saskowski J, Tikhomirov O, Chen L, Lee HJ, Yull F, Khabele D. Tracking NF-¿B activity in tumor cells during ovarian cancer progression in a syngeneic mouse model. J Ovarian Res. 2013; 6(1): 63. PMID: 24020521, PMCID: PMC3846584, PII: 1757-2215-6-63, DOI: 10.1186/1757-2215-6-63, ISSN: 1757-2215.

Zaidi SS, Lakhani VT, Fadare O, Khabele D. Adrenal gland metastasis is an unusual manifestation of endometrial cancer. Case Rep Surg [print-electronic]. 2013; 2013: 428456. PMID: 23984164, PMCID: PMC3748408, DOI: 10.1155/2013/428456, ISSN: 2090-6900.

Wells CE, Bhaskara S, Stengel KR, Zhao Y, Sirbu B, Chagot B, Cortez D, Khabele D, Chazin WJ, Cooper A, Jacques V, Rusche J, Eischen CM, McGirt LY, Hiebert SW. Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS ONE [electronic-print]. 2013; 8(7): e68915. PMID: 23894374, PMCID: PMC3718806, PII: PONE-D-13-03947, DOI: 10.1371/journal.pone.0068915, ISSN: 1932-6203.

Ayuso A, Fadare O, Khabele D. A case of extrauterine endometrial stromal sarcoma in the colon diagnosed three decades after hysterectomy for benign disease. Case Rep Obstet Gynecol [print-electronic]. 2013; 2013: 202458. PMID: 23710389, PMCID: PMC3655501, DOI: 10.1155/2013/202458, ISSN: 2090-6684.

Fadare O, Zheng W, Crispens MA, Jones HW, Khabele D, Gwin K, Liang SX, Mohammed K, Desouki MM, Parkash V, Hecht JL. Morphologic and other clinicopathologic features of endometrial clear cell carcinoma: a comprehensive analysis of 50 rigorously classified cases. Am J Cancer Res [print-electronic]. 2013; 3(1): 70-95. PMID: 23359866, PMCID: PMC3555196, ISSN: 2156-6976.

Wilson AJ, Lalani AS, Wass E, Saskowski J, Khabele D. Romidepsin (FK228) combined with cisplatin stimulates DNA damage-induced cell death in ovarian cancer. Gynecol. Oncol [print-electronic]. 2012 Dec; 127(3): 579-86. PMID: 23010348, PMCID: PMC3541411, PII: S0090-8258(12)00772-X, DOI: 10.1016/j.ygyno.2012.09.016, ISSN: 1095-6859.

Vargis E, Tang YW, Khabele D, Mahadevan-Jansen A. Near-infrared Raman Microspectroscopy Detects High-risk Human Papillomaviruses. Transl Oncol [print-electronic]. 2012 Jun; 5(3): 172-9. PMID: 22741036, PMCID: PMC3384271, ISSN: 1936-5233.

Khabele D, Fadare O, Liu AY, Wilson AJ, Wass E, Osteen K, Crispens MA. An orthotopic model of platinum-sensitive high grade serous fallopian tube carcinoma. Int J Clin Exp Pathol [print-electronic]. 2012; 5(1): 37-45. PMID: 22295145, PMCID: PMC3267484, ISSN: 1936-2625.

Wilson AJ, Cheng YQ, Khabele D. Thailandepsins are new small molecule class I HDAC inhibitors with potent cytotoxic activity in ovarian cancer cells: a preclinical study of epigenetic ovarian cancer therapy. J Ovarian Res. 2012; 5(1): 12. PMID: 22531354, PMCID: PMC3394212, PII: 1757-2215-5-12, DOI: 10.1186/1757-2215-5-12, ISSN: 1757-2215.

Vargis E, Byrd T, Logan Q, Khabele D, Mahadevan-Jansen A. Sensitivity of Raman spectroscopy to normal patient variability. J Biomed Opt. 2011 Nov; 16(11): 117004. PMID: 22112136, PMCID: PMC3221719, DOI: 10.1117/1.3646210, ISSN: 1560-2281.

Wilson AJ, Holson E, Wagner F, Zhang YL, Fass DM, Haggarty SJ, Bhaskara S, Hiebert SW, Schreiber SL, Khabele D. The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells. Cancer Biol. Ther [print-electronic]. 2011 Sep 9/15/2011; 12(6): 484-93. PMID: 21738006, PMCID: PMC3218590, PII: 15956, DOI: 10.4161/cbt.12.6.15956, ISSN: 1555-8576.

Fadare O, Khabele D. Pleomorphic liposarcoma of the uterine corpus with focal smooth muscle differentiation. Int. J. Gynecol. Pathol. 2011 May; 30(3): 282-7. PMID: 21464725, DOI: 10.1097/PGP.0b013e31820086a4, ISSN: 1538-7151.

Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell. 2010 Nov 11/16/2010; 18(5): 436-47. PMID: 21075309, PMCID: PMC3004468, PII: S1535-6108(10)00424-1, DOI: 10.1016/j.ccr.2010.10.022, ISSN: 1878-3686.

Son DS, Wilson AJ, Parl AK, Khabele D. The effects of the histone deacetylase inhibitor romidepsin (FK228) are enhanced by aspirin (ASA) in COX-1 positive ovarian cancer cells through augmentation of p21. Cancer Biol. Ther [print-electronic]. 2010 Jun 6/1/2010; 9(11): 928-35. PMID: 20404564, PMCID: PMC4047717, PII: 11873, ISSN: 1555-8576.

Klugman SD, Gross SJ, Liang J, Livne K, Gross B, Khabele D, Lopez-Jones M, Cordero DR, Reznik S. Expression of Keratin 8 and TNF-Related Apoptosis-I Inducing Ligand (TRAIL) in Down Syndrome Placentas [letter]. Placenta [print-electronic]. 2008 Apr; 29(4): 382-4. PMID: 18343496, PMCID: PMC2475678, PII: S0143-4004(08)00032-5, DOI: 10.1016/j.placenta.2008.01.013, ISSN: 0143-4004.

Lyshchik A, Hobbs SB, Fleischer AC, Khabele D, Son DS, Gore JC, Price RR. Ovarian volume measurements in mice with high-resolution ultrasonography. J Ultrasound Med. 2007 Oct; 26(10): 1419-25. PMID: 17901144, PII: 26/10/1419, ISSN: 0278-4297.

Son DS, Parl AK, Rice VM, Khabele D. Keratinocyte chemoattractant (KC)/human growth-regulated oncogene (GRO) chemokines and pro-inflammatory chemokine networks in mouse and human ovarian epithelial cancer cells. Cancer Biol. Ther [print-electronic]. 2007 Aug; 6(8): 1302-12. PMID: 17712227, PII: 4506, ISSN: 1555-8576.

Daikoku T, Tranguch S, Chakrabarty A, Wang D, Khabele D, Orsulic S, Morrow JD, Dubois RN, Dey SK. Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer. Cancer Res. 2007 Jun 6/1/2007; 67(11): 5285-92. PMID: 17545608, PII: 67/11/5285, DOI: 10.1158/0008-5472.CAN-07-0828, ISSN: 0008-5472.

Khabele D, Son DS, Parl AK, Goldberg GL, Augenlicht LH, Mariadason JM, Rice VM. Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy. Cancer Biol. Ther [print-electronic]. 2007 May; 6(5): 795-801. PMID: 17387270, PII: 4007, ISSN: 1555-8576.

Gorelick C, Lopez-Jones M, Goldberg GL, Romney SL, Khabele D. Coenzyme Q10 and lipid-related gene induction in HeLa cells. Am. J. Obstet. Gynecol. 2004 May; 190(5): 1432-4. PMID: 15167860, PII: S0002937804001619, DOI: 10.1016/j.ajog.2004.01.076, ISSN: 0002-9378.

Khabele D, Lopez-Jones M, Yang W, Arango D, Gross SJ, Augenlicht LH, Goldberg GL. Tumor necrosis factor-alpha related gene response to Epothilone B in ovarian cancer. Gynecol. Oncol. 2004 Apr; 93(1): 19-26. PMID: 15047209, PII: S0090825803008515, DOI: 10.1016/j.ygyno.2003.11.058, ISSN: 0090-8258.

Sood BM, Jones J, Gupta S, Khabele D, Guha C, Runowicz C, Goldberg G, Fields A, Anderson P, Vikram B. Patterns of failure after the multimodality treatment of uterine papillary serous carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 2003 Sep 9/1/2003; 57(1): 208-16. PMID: 12909235, PII: S0360301603005315, ISSN: 0360-3016.

Khabele D, Runowicz CD, Fields AL, Anderson PS, Goldberg GL. Evaluation of low-dose intraperitoneal interferon-alpha for palliation of ascites in patients with non-ovarian gynecologic malignancies. Gynecol. Oncol. 2003 Jun; 89(3): 420-3. PMID: 12798705, PII: S0090825803000805, ISSN: 0090-8258.

Gross SJ, Ferreira JC, Morrow B, Dar P, Funke B, Khabele D, Merkatz I. Gene expression profile of trisomy 21 placentas: a potential approach for designing noninvasive techniques of prenatal diagnosis. Am. J. Obstet. Gynecol. 2002 Aug; 187(2): 457-62. PMID: 12193943, PII: S0002937802001527, ISSN: 0002-9378.

Khabele D, Runowicz CD. Genetic counseling, testing, and screening for breast and ovarian cancer: practical and social considerations. Curr Womens Health Rep. 2002 Jun; 2(3): 163-9. PMID: 12099190, ISSN: 1534-5874.

Khabele D, Chasen S. Cardiac tamponade as an unusual presentation of advanced breast cancer in pregnancy. J Reprod Med. 1999 Nov; 44(11): 989-91. PMID: 10589415, ISSN: 0024-7758.

Xiao E, Xia L, Shanen D, Khabele D, Ferin M. Stimulatory effects of interleukin-induced activation of the hypothalamo-pituitary-adrenal axis on gonadotropin secretion in ovariectomized monkeys replaced with estradiol. Endocrinology. 1994 Nov; 135(5): 2093-8. PMID: 7956932, DOI: 10.1210/endo.135.5.7956932, ISSN: 0013-7227.