Alan D. Cherrington, Ph.D.

Professor

alan.cherrington@vanderbilt.edu

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Faculty Appointments
Professor of Molecular Physiology and Biophysics Jacquelyn A. Turner and Dr. Dorothy J. Turner Chair in Diabetes ResearchProfessor of Medicine
Education
Ph.D., Physiology, University of Toronto, TorontoM.Sc., Physiology, University of Toronto, TorontoB.Sc., Biology, University of New Brunswick, New Brunswick
Office Address
702 Light Hall
704A Robinson Research Bldg
Nashville, TN 37232-0615
Research Description
A decade ago the synthesis of glycogen which occurs in the liver after oral glucose feeding was thought to be the result of the ingested glucose triggering insulin release and the insulin in turn causing the liver to take up and store the glucose. It is now clear that this storage response is much more complicated than first thought. We now know that another signal, as yet poorly understood, is involved in activating the liver, and further, that much of the glycogen deposited does not come "directly" from ingested glucose but "indirectly" from 3-carbon precursors which enter liver glycogen via the gluconeogenic pathway. We are currently using a chronically catheterized dog model to study the physiology of this "new" signal and the conditions under which liver glycogen is synthesized via the "direct" or "indirect" routes.

Remarkably, if the body is exposed to an insulin level 30 times normal, the resulting hypoglycemia will be limited to a level compatible with life. The reason for this life saving response is that the stimulatory effect of insulin on glucose utilization and its inhibitory effect on glucose production are limited by a variety of hormonal and neural mechanisms. We are currently investigating the role of each mechanism in limiting insulin induced hypoglycemia using conscious dogs. In addition, we are studying the ability of the brain to sense and respond directly to insulin via vertebral and carotid artery infusion or insulin infusion into the 3rd ventricle. We are also examining the defects which occur in counterregulation in diabetes.

We continue to define the actions of various hormones (insulin, glucagon, epinephrine, cortisol) and neural mediators (norepinephrine, acetylcholine, cGRP, NPY) and drugs on glucose production (glycogenolysis and gluconeogenesis) and utilization by the liver.

Our experiments are carried out in vivo using transgenic mice, the conscious dog and man or in vitro using perfused liver and isolated liver cells. Control over various aspects of the endocrine and/or nervous system is gained using pharmacologic and/or surgical techniques. The rates of glucose production (glycogenolysis; gluconeogenesis) and utilization, as well as ketone body production and clearance are assessed using tracer and arteriovenous differences techniques.
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Research Keywords
diabetes, glycogenolysis, gluconeogenesis, physiology
Publications
Cherrington AD. Central versus peripheral glucose sensing and the response to hypoglycemia. Diabetes. 2008 May; 57(5): 1158-9. PMID: 18443372, PII: 57/5/1158, DOI: 10.2337/db08-0315, ISSN: 1939-327X.

Nishizawa M, Shiota M, Moore MC, Gustavson SM, Neal DW, Cherrington AD. Intraportal administration of neuropeptide Y and hepatic glucose metabolism. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2008 Apr; 294(4): R1197-204. PMID: 18234742, PII: 00903.2007, DOI: 10.1152/ajpregu.00903.2007, ISSN: 0363-6119.

Moore MC, Dicostanzo CA, Smith MS, Farmer B, Rodewald TD, Neal DW, Williams PE, Cherrington AD. Hepatic portal venous delivery of a nitric oxide synthase inhibitor enhances net hepatic glucose uptake. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2008 Apr; 294(4): E768-77. PMID: 18212022, PII: 00184.2007, DOI: 10.1152/ajpendo.00184.2007, ISSN: 0193-1849.

Johnson KM, Edgerton DS, Rodewald T, Scott M, Farmer B, Neal D, Cherrington AD. Intraportally delivered GLP-1, in the presence of hyperglycemia induced via peripheral glucose infusion, does not change whole body glucose utilization. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2008 Feb; 294(2): E380-4. PMID: 18056788, PII: 00642.2007, DOI: 10.1152/ajpendo.00642.2007, ISSN: 0193-1849.

An Z, DiCostanzo CA, Moore MC, Edgerton DS, Dardevet DP, Neal DW, Cherrington AD. Effects of the nitric oxide donor SIN-1 on net hepatic glucose uptake in the conscious dog. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2008 Feb; 294(2): E300-6. PMID: 18029444, PII: 00380.2007, DOI: 10.1152/ajpendo.00380.2007, ISSN: 0193-1849.

Johnson KM, Edgerton DS, Rodewald T, Scott M, Farmer B, Neal D, Cherrington AD. Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing pancreatic hormone levels. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2007 Oct; 293(4): E1085-91. PMID: 17684104, PII: 00275.2007, DOI: 10.1152/ajpendo.00275.2007, ISSN: 0193-1849.

Nelson RH, Edgerton DS, Basu R, Roesner JC, Cherrington AD, Miles JM. Triglyceride uptake and lipoprotein lipase-generated fatty acid spillover in the splanchnic bed of dogs. Diabetes [print-electronic]. 2007 Jul; 56(7): 1850-5. PMID: 17416801, PII: db06-1657, DOI: 10.2337/db06-1657, ISSN: 1939-327X.

DiCostanzo CA, Dardevet DP, Williams PE, Moore MC, Hastings JR, Neal DW, Cherrington AD. The effect of vagal cooling on canine hepatic glucose metabolism in the presence of hyperglycemia of peripheral origin. Metab. Clin. Exp. 2007 Jun; 56(6): 814-24. PMID: 17512315, PII: S0026-0495(07)00067-4, DOI: 10.1016/j.metabol.2007.01.012, ISSN: 0026-0495.

Rivera N, Everett-Grueter CA, Edgerton DS, Rodewald T, Neal DW, Nishimura E, Larsen MO, Jacobsen LO, Kristensen K, Brand CL, Cherrington AD. A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog. J. Pharmacol. Exp. Ther [print-electronic]. 2007 May; 321(2): 743-52. PMID: 17308040, PII: jpet.106.115717, DOI: 10.1124/jpet.106.115717, ISSN: 0022-3565.

Edgerton DS, Cherrington AD, Williams P, Neal DW, Scott M, Bowen L, Wilson W, Hobbs CH, Leach C, Kuo MC, Strack TR. Inhalation of human insulin (exubera) augments the efficiency of muscle glucose uptake in vivo. Diabetes. 2006 Dec; 55(12): 3604-10. PMID: 17130510, PII: 55/12/3604, DOI: 10.2337/db06-0718, ISSN: 0012-1797.

Edgerton DS, Stettler KM, Neal DW, Scott M, Bowen L, Wilson W, Hobbs CH, Leach C, Strack TR, Cherrington AD. Inhalation of human insulin is associated with improved insulin action compared with subcutaneous injection and endogenous secretion in dogs. J. Pharmacol. Exp. Ther [print-electronic]. 2006 Dec; 319(3): 1258-64. PMID: 16963622, PII: jpet.106.108373, DOI: 10.1124/jpet.106.108373, ISSN: 0022-3565.

Basu R, Edgerton DS, Singh RJ, Cherrington A, Rizza RA. Splanchnic cortisol production in dogs occurs primarily in the liver: evidence for substantial hepatic specific 11beta hydroxysteroid dehydrogenase type 1 activity. Diabetes. 2006 Nov; 55(11): 3013-9. PMID: 17065337, PII: 55/11/3013, DOI: 10.2337/db06-0601, ISSN: 0012-1797.

Edgerton DS, Jacobson PB, Opgenorth TJ, Zinker B, Beno D, von Geldern T, Ohman L, Scott M, Neal D, Cherrington AD. Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production. Metab. Clin. Exp. 2006 Sep; 55(9): 1255-62. PMID: 16919547, PII: S0026-0495(06)00178-8, DOI: 10.1016/j.metabol.2006.05.011, ISSN: 0026-0495.

Everett-Grueter C, Edgerton DS, Donahue EP, Vaughan S, Chu CA, Sindelar DK, Cherrington AD. The effect of an acute elevation of NEFA concentrations on glucagon-stimulated hepatic glucose output. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2006 Sep; 291(3): E449-59. PMID: 16608886, PII: 00043.2006, DOI: 10.1152/ajpendo.00043.2006, ISSN: 0193-1849.

Edgerton DS, Lautz M, Scott M, Everett CA, Stettler KM, Neal DW, Chu CA, Cherrington AD. Insulin's direct effects on the liver dominate the control of hepatic glucose production. J. Clin. Invest. 2006 Feb; 116(2): 521-7. PMID: 16453026, PMCID: PMC1359060, DOI: 10.1172/JCI27073, ISSN: 0021-9738.

Dicostanzo CA, Dardevet DP, Neal DW, Lautz M, Allen E, Snead W, Cherrington AD. Role of the hepatic sympathetic nerves in the regulation of net hepatic glucose uptake and the mediation of the portal glucose signal. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2006 Jan; 290(1): E9-E16. PMID: 16105863, PII: 00184.2005, DOI: 10.1152/ajpendo.00184.2005, ISSN: 0193-1849.

Dardevet D, Moore MC, DiCostanzo CA, Farmer B, Neal DW, Snead W, Lautz M, Cherrington AD. Insulin secretion-independent effects of GLP-1 on canine liver glucose metabolism do not involve portal vein GLP-1 receptors. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2005 Nov; 289(5): G806-14. PMID: 16051922, PMCID: PMC2435373, PII: 00121.2005, DOI: 10.1152/ajpgi.00121.2005, ISSN: 0193-1857.

Gustavson SM, Rajotte RV, Hunkeler D, Lakey JR, Edgerton DS, Neal DW, Snead WL, Penaloza AR, Cherrington AD. Islet auto-transplantation into an omental or splenic site results in a normal beta cell but abnormal alpha cell response to mild non-insulin-induced hypoglycemia. Am. J. Transplant. 2005 Oct; 5(10): 2368-77. PMID: 16162184, PII: AJT1041, DOI: 10.1111/j.1600-6143.2005.01041.x, ISSN: 1600-6135.

Grubert JM, Lautz M, Lacy DB, Moore MC, Farmer B, Penaloza A, Cherrington AD, McGuinness OP. Impact of continuous and pulsatile insulin delivery on net hepatic glucose uptake. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2005 Aug; 289(2): E232-40. PMID: 15755768, PII: 00567.2004, DOI: 10.1152/ajpendo.00567.2004, ISSN: 0193-1849.

Moore MC, Kimura K, Shibata H, Honjoh T, Saito M, Everett CA, Smith MS, Cherrington AD. Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2005 Aug; 289(2): E225-31. PMID: 15755767, PMCID: PMC2430063, PII: 00614.2004, DOI: 10.1152/ajpendo.00614.2004, ISSN: 0193-1849.

DiCostanzo CA, Moore MC, Lautz M, Scott M, Farmer B, Everett CA, Still JG, Higgins A, Cherrington AD. Simulated first-phase insulin release using Humulin or insulin analog HIM2 is associated with prolonged improvement in postprandial glycemia. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2005 Jul; 289(1): E46-52. PMID: 15713685, PII: 00583.2004, DOI: 10.1152/ajpendo.00583.2004, ISSN: 0193-1849.

Jacobson PB, von Geldern TW, Ohman L, Osterland M, Wang J, Zinker B, Wilcox D, Nguyen PT, Mika A, Fung S, Fey T, Goos-Nilsson A, Grynfarb M, Barkhem T, Marsh K, Beno DW, Nga-Nguyen B, Kym PR, Link JT, Tu N, Edgerton DS, Cherrington A, Efendic S, Lane BC, Opgenorth TJ. Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes. J. Pharmacol. Exp. Ther [print-electronic]. 2005 Jul; 314(1): 191-200. PMID: 15784656, PII: jpet.104.081257, DOI: 10.1124/jpet.104.081257, ISSN: 0022-3565.

Shiota M, Galassetti P, Igawa K, Neal DW, Cherrington AD. Inclusion of low amounts of fructose with an intraportal glucose load increases net hepatic glucose uptake in the presence of relative insulin deficiency in dog. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2005 Jun; 288(6): E1160-7. PMID: 15671083, PII: 00391.2004, DOI: 10.1152/ajpendo.00391.2004, ISSN: 0193-1849.

Cherrington AD. The role of hepatic insulin receptors in the regulation of glucose production. J. Clin. Invest. 2005 May; 115(5): 1136-9. PMID: 15864342, PMCID: PMC1087191, DOI: 10.1172/JCI25152, ISSN: 0021-9738.

Edgerton DS, Neal DW, Scott M, Bowen L, Wilson W, Hobbs CH, Leach C, Sivakumaran S, Strack TR, Cherrington AD. Inhalation of insulin (Exubera) is associated with augmented disposal of portally infused glucose in dogs. Diabetes. 2005 Apr; 54(4): 1164-70. PMID: 15793257, PII: 54/4/1164, ISSN: 0012-1797.

Moore MC, DiCostanzo CA, Dardevet D, Lautz M, Farmer B, Cherrington AD. Interaction of a selective serotonin reuptake inhibitor with insulin in the control of hepatic glucose uptake in conscious dogs. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2005 Mar; 288(3): E556-63. PMID: 15522992, PII: 00405.2004, DOI: 10.1152/ajpendo.00405.2004, ISSN: 0193-1849.

Moore MC, DiCostanzo CA, Dardevet D, Lautz M, Farmer B, Neal DW, Cherrington AD. Portal infusion of a selective serotonin reuptake inhibitor enhances hepatic glucose disposal in conscious dogs. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Dec; 287(6): E1057-63. PMID: 15315909, PII: 00313.2004, DOI: 10.1152/ajpendo.00313.2004, ISSN: 0193-1849.

Cardin S, Pagliassotti MJ, Moore MC, Edgerton DS, Lautz M, Farmer B, Neal DW, Cherrington AD. Vagal cooling and concomitant portal norepinephrine infusion do not reduce net hepatic glucose uptake in conscious dogs. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2004 Oct; 287(4): R742-8. PMID: 15166005, PII: 00041.2004, DOI: 10.1152/ajpregu.00041.2004, ISSN: 0363-6119.

Gustavson SM, Chu CA, Nishizawa M, Neal D, Farmer B, Yang Y, Donahue EP, Flakoll P, Cherrington AD. Effects of hyperglycemia, glucagon, and epinephrine on renal glucose release in the conscious dog. Metab. Clin. Exp. 2004 Jul; 53(7): 933-41. PMID: 15254890, PII: S0026049504001155, ISSN: 0026-0495.

Dardevet D, Moore MC, Neal D, DiCostanzo CA, Snead W, Cherrington AD. Insulin-independent effects of GLP-1 on canine liver glucose metabolism: duration of infusion and involvement of hepatoportal region. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Jul; 287(1): E75-81. PMID: 15026303, PII: 00035.2004, DOI: 10.1152/ajpendo.00035.2004, ISSN: 0193-1849.

Hornbuckle LA, Everett CA, Martin CC, Gustavson SS, Svitek CA, Oeser JK, Neal DW, Cherrington AD, O'Brien RM. Selective stimulation of G-6-Pase catalytic subunit but not G-6-P transporter gene expression by glucagon in vivo and cAMP in situ. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 May; 286(5): E795-808. PMID: 14722027, PII: 00455.2003, DOI: 10.1152/ajpendo.00455.2003, ISSN: 0193-1849.

Cherrington AD, Neal DW, Edgerton DS, Glass D, Bowen L, Hobbs CH, Leach C, Rosskamp R, Strack TR. Inhalation of insulin in dogs: assessment of insulin levels and comparison to subcutaneous injection. Diabetes. 2004 Apr; 53(4): 877-81. PMID: 15047601, ISSN: 0012-1797.

Chu CA, Fujimoto Y, Igawa K, Grimsby J, Grippo JF, Magnuson MA, Cherrington AD, Shiota M. Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2004 Apr; 286(4): G627-34. PMID: 14656711, PII: 00218.2003, DOI: 10.1152/ajpgi.00218.2003, ISSN: 0193-1857.

Edgerton DS, Cardin S, Neal D, Farmer B, Lautz M, Pan C, Cherrington AD. Effects of hyperglycemia on hepatic gluconeogenic flux during glycogen phosphorylase inhibition in the conscious dog. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Apr; 286(4): E510-22. PMID: 14644767, PII: 00211.2003, DOI: 10.1152/ajpendo.00211.2003, ISSN: 0193-1849.

Moore MC, Cardin S, Edgerton DS, Farmer B, Neal DW, Lautz M, Cherrington AD. Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Feb; 286(2): E226-33. PMID: 14519598, PII: 00343.2003, DOI: 10.1152/ajpendo.00343.2003, ISSN: 0193-1849.

Moore MC, Satake S, Lautz M, Soleimanpour SA, Neal DW, Smith M, Cherrington AD. Nonesterified fatty acids and hepatic glucose metabolism in the conscious dog. Diabetes. 2004 Jan; 53(1): 32-40. PMID: 14693695, ISSN: 0012-1797.

Moore MC, Geho WB, Lautz M, Farmer B, Neal DW, Cherrington AD. Portal serotonin infusion and glucose disposal in conscious dogs. Diabetes. 2004 Jan; 53(1): 14-20. PMID: 14693692, ISSN: 0012-1797.

Gustavson SM, Nishizawa M, Farmer B, Neal D, Brissova M, Powers AC, Cherrington AD. A fall in portal vein insulin does not cause the alpha-cell response to mild, non-insulin-induced hypoglycemia in conscious dogs. Metab. Clin. Exp. 2003 Nov; 52(11): 1418-25. PMID: 14624400, PII: S0026049503003214, ISSN: 0026-0495.

Moore MC, Burish MJ, Farmer B, Neal DW, Pan C, Cherrington AD. Chronic hepatic artery ligation does not prevent liver from differentiating portal vs. peripheral glucose delivery. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2003 Oct; 285(4): E845-53. PMID: 12773306, PII: 00130.2003, DOI: 10.1152/ajpendo.00130.2003, ISSN: 0193-1849.

Moore MC, Cherrington AD, Wasserman DH. Regulation of hepatic and peripheral glucose disposal. Best Pract. Res. Clin. Endocrinol. Metab. 2003 Sep; 17(3): 343-64. PMID: 12962690, PII: S1521690X03000368, ISSN: 1521-690X.

Gustavson SM, Chu CA, Nishizawa M, Farmer B, Neal D, Yang Y, Vaughan S, Donahue EP, Flakoll P, Cherrington AD. Glucagon's actions are modified by the combination of epinephrine and gluconeogenic precursor infusion. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2003 Sep; 285(3): E534-44. PMID: 12736160, PII: 00059.2003, DOI: 10.1152/ajpendo.00059.2003, ISSN: 0193-1849.

Jensen MD, Cardin S, Edgerton D, Cherrington A. Splanchnic free fatty acid kinetics. Am. J. Physiol. Endocrinol. Metab. 2003 Jun; 284(6): E1140-8. PMID: 12736157, PII: 284/6/E1140, DOI: 10.1152/ajpendo.00268.2002, ISSN: 0193-1849.

Nishizawa M, Moore MC, Shiota M, Gustavson SM, Snead WL, Neal DW, Cherrington AD. Effect of intraportal glucagon-like peptide-1 on glucose metabolism in conscious dogs. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2003 May; 284(5): E1027-36. PMID: 12569088, PII: 00503.2002, DOI: 10.1152/ajpendo.00503.2002, ISSN: 0193-1849.

Gustavson SM, Chu CA, Nishizawa M, Farmer B, Neal D, Yang Y, Donahue EP, Flakoll P, Cherrington AD. Interaction of glucagon and epinephrine in the control of hepatic glucose production in the conscious dog. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2003 Apr; 284(4): E695-707. PMID: 12626324, PII: 00308.2002, DOI: 10.1152/ajpendo.00308.2002, ISSN: 0193-1849.

Chu CA, Galassetti P, Igawa K, Sindelar DK, Neal DW, Burish M, Cherrington AD. Interaction of free fatty acids and epinephrine in regulating hepatic glucose production in conscious dogs. Am. J. Physiol. Endocrinol. Metab. 2003 Feb; 284(2): E291-301. PMID: 12531743, PII: 284/2/E291, DOI: 10.1152/ajpendo.00565.2001, ISSN: 0193-1849.

Edgerton DS, Cardin S, Pan C, Neal D, Farmer B, Converse M, Cherrington AD. Effects of insulin deficiency or excess on hepatic gluconeogenic flux during glycogenolytic inhibition in the conscious dog. Diabetes. 2002 Nov; 51(11): 3151-62. PMID: 12401705, ISSN: 0012-1797.

Cardin S, Walmsley K, Neal DW, Williams PE, Cherrington AD. Involvement of the vagus nerves in the regulation of basal hepatic glucose production in conscious dogs. Am. J. Physiol. Endocrinol. Metab. 2002 Nov; 283(5): E958-64. PMID: 12376322, DOI: 10.1152/ajpendo.00566.2001, ISSN: 0193-1849.

Goldstein RE, Rossetti L, Palmer BA, Liu R, Massillon D, Scott M, Neal D, Williams P, Peeler B, Cherrington AD. Effects of fasting and glucocorticoids on hepatic gluconeogenesis assessed using two independent methods in vivo. Am. J. Physiol. Endocrinol. Metab. 2002 Nov; 283(5): E946-57. PMID: 12376321, DOI: 10.1152/ajpendo.00320.2002, ISSN: 0193-1849.

Igawa K, Mugavero M, Shiota M, Neal DW, Cherrington AD. Insulin sensitively controls the glucagon response to mild hypoglycemia in the dog. Diabetes. 2002 Oct; 51(10): 3033-42. PMID: 12351444, ISSN: 0012-1797.

Satake S, Moore MC, Igawa K, Converse M, Farmer B, Neal DW, Cherrington AD. Direct and indirect effects of insulin on glucose uptake and storage by the liver. Diabetes. 2002 Jun; 51(6): 1663-71. PMID: 12031951, ISSN: 0012-1797.

Cherrington AD, Sindelar D, Edgerton D, Steiner K, McGuinness OP. Physiological consequences of phasic insulin release in the normal animal. Diabetes. 2002 Feb; 51 Suppl 1: S103-8. PMID: 11815467, ISSN: 0012-1797.

Shiota M, Moore MC, Galassetti P, Monohan M, Neal DW, Shulman GI, Cherrington AD. Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog. Diabetes. 2002 Feb; 51(2): 469-78. PMID: 11812757, ISSN: 0012-1797.

Chu CA, Sherck SM, Igawa K, Sindelar DK, Neal DW, Emshwiller M, Cherrington AD. Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs. Am. J. Physiol. Endocrinol. Metab. 2002 Feb; 282(2): E402-11. PMID: 11788373, DOI: 10.1152/ajpendo.00136.2001, ISSN: 0193-1849.

Moore MC, Satake S, Baranowski B, Hsieh PS, Neal DW, Cherrington AD. Effect of hepatic denervation on peripheral insulin sensitivity in conscious dogs. Am. J. Physiol. Endocrinol. Metab. 2002 Feb; 282(2): E286-96. PMID: 11788359, DOI: 10.1152/ajpendo.00201.2001, ISSN: 0193-1849.

Moore MC, Cherrington AD, Palmer B, Lacy DB, Goldstein RE. Effects of cyclosporine A and prednisone treatment on mixed meal disposition in dogs with hepatic denervation. JPEN J Parenter Enteral Nutr. 2002 Jan; 26(1): 42-50. PMID: 11833750, ISSN: 0148-6071.

Dunning, BE, Moore, MC, Ikeda, T, Neal, DW, Scott, MF, Cherrington, AD. Evidence for a neurally-mediated incretin effect of portal vs peripheral glucose infusion in conscious dogs. Metabolism. 2002; 51: 1324-30.

Moore MC, Davis SN, Mann SL, Cherrington AD. Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes. Diabetes Care. 2001 Nov; 24(11): 1882-7. PMID: 11679451, ISSN: 0149-5992.

Sherck SM, Shiota M, Saccomando J, Cardin S, Allen EJ, Hastings JR, Neal DW, Williams PE, Cherrington AD. Pancreatic response to mild non-insulin-induced hypoglycemia does not involve extrinsic neural input. Diabetes. 2001 Nov; 50(11): 2487-96. PMID: 11679426, ISSN: 0012-1797.

Hornbuckle LA, Edgerton DS, Ayala JE, Svitek CA, Oeser JK, Neal DW, Cardin S, Cherrington AD, O'Brien RM. Selective tonic inhibition of G-6-Pase catalytic subunit, but not G-6-P transporter, gene expression by insulin in vivo. Am. J. Physiol. Endocrinol. Metab. 2001 Oct; 281(4): E713-25. PMID: 11551847, ISSN: 0193-1849.

Edgerton DS, Cardin S, Emshwiller M, Neal D, Chandramouli V, Schumann WC, Landau BR, Rossetti L, Cherrington AD. Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism. Diabetes. 2001 Aug; 50(8): 1872-82. PMID: 11473051, ISSN: 0012-1797.

Shiota M, Postic C, Fujimoto Y, Jetton TL, Dixon K, Pan D, Grimsby J, Grippo JF, Magnuson MA, Cherrington AD. Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes. Diabetes. 2001 Mar; 50(3): 622-9. PMID: 11246883, ISSN: 0012-1797.

Cardin S, Jackson PA, Edgerton DS, Neal DW, Coffey CS, Cherrington AD. Effect of vagal cooling on the counterregulatory response to hypoglycemia induced by a low dose of insulin in the conscious dog. Diabetes. 2001 Mar; 50(3): 558-64. PMID: 11246875, ISSN: 0012-1797.

Flattem N, Igawa K, Shiota M, Emshwiller MG, Neal DW, Cherrington AD. Alpha- and beta-cell responses to small changes in plasma glucose in the conscious dog. Diabetes. 2001 Feb; 50(2): 367-75. PMID: 11272149, ISSN: 0012-1797.

Jetton TL, Shiota M, Knobel SM, Piston DW, Cherrington AD, Magnuson MA. Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition. Int. J. Exp. Diabetes Res. 2001; 2(3): 173-86. PMID: 12369705, PMCID: PMC2478546, ISSN: 1560-4284.

Chu CA, Wiernsperger N, Muscato N, Knauf M, Neal DW, Cherrington AD. The acute effect of metformin on glucose production in the conscious dog is primarily attributable to inhibition of glycogenolysis. Metab. Clin. Exp. 2000 Dec; 49(12): 1619-26. PMID: 11145127, PII: S0026-0495(00)94600-6, DOI: 10.1053/meta.2000.18561, ISSN: 0026-0495.

Moore MC, Cherrington AD, Mann SL, Davis SN. Acute fructose administration decreases the glycemic response to an oral glucose tolerance test in normal adults. J. Clin. Endocrinol. Metab. 2000 Dec; 85(12): 4515-9. PMID: 11134101, DOI: 10.1210/jcem.85.12.7053, ISSN: 0021-972X.

Moore MC, Hsieh PS, Neal DW, Cherrington AD. Nonhepatic response to portal glucose delivery in conscious dogs. Am. J. Physiol. Endocrinol. Metab. 2000 Dec; 279(6): E1271-7. PMID: 11093914, ISSN: 0193-1849.

Jackson PA, Cardin S, Coffey CS, Neal DW, Allen EJ, Penaloza AR, Snead WL, Cherrington AD. Effect of hepatic denervation on the counterregulatory response to insulin-induced hypoglycemia in the dog. Am. J. Physiol. Endocrinol. Metab. 2000 Dec; 279(6): E1249-57. PMID: 11093911, ISSN: 0193-1849.

Connolly CC, Holste LC, Aglione LN, Neal DW, Lacy DB, Smith MS, Diamond MP, Cherrington AD, Chiasson JL. Alterations in basal glucose metabolism during late pregnancy in the conscious dog. Am. J. Physiol. Endocrinol. Metab. 2000 Nov; 279(5): E1166-77. PMID: 11052973, ISSN: 0193-1849.

Chu CA, Sindelar DK, Igawa K, Sherck S, Neal DW, Emshwiller M, Cherrington AD. The direct effects of catecholamines on hepatic glucose production occur via alpha(1)- and beta(2)-receptors in the dog. Am. J. Physiol. Endocrinol. Metab. 2000 Aug; 279(2): E463-73. PMID: 10913048, ISSN: 0193-1849.

Hsieh PS, Moore MC, Neal DW, Cherrington AD. Importance of the hepatic arterial glucose level in generation of the portal signal in conscious dogs. Am. J. Physiol. Endocrinol. Metab. 2000 Aug; 279(2): E284-92. PMID: 10913027, ISSN: 0193-1849.

Moore MC, Cherrington AD, Palmer B, Lacy DB, Goldstein RE. Disposition of a mixed meal by conscious dogs after seven days of treatment with cyclosporine A and prednisone. JPEN J Parenter Enteral Nutr. 2000 Jul; 24(4): 244-50. PMID: 10885720, ISSN: 0148-6071.

Shiota M, Jackson P, Galassetti P, Scott M, Neal DW, Cherrington AD. Combined intraportal infusion of acetylcholine and adrenergic blockers augments net hepatic glucose uptake. Am. J. Physiol. Endocrinol. Metab. 2000 Mar; 278(3): E544-52. PMID: 10710510, ISSN: 0193-1849.

Galassetti P, Koyama Y, Coker RH, Lacy DB, Cherrington AD, Wasserman DH. Role of a negative arterial-portal venous glucose gradient in the postexercise state. Am. J. Physiol. 1999 Dec; 277(6 Pt 1): E1038-45. PMID: 10600793, ISSN: 0002-9513.

Moore MC, Hsieh PS, Flakoll PJ, Neal DW, Cherrington AD. Net hepatic gluconeogenic amino acid uptake in response to peripheral versus portal amino acid infusion in conscious dogs. J. Nutr. 1999 Dec; 129(12): 2218-24. PMID: 10573553, ISSN: 0022-3166.

Cardin S, Emshwiller M, Jackson PA, Snead WL, Hastings J, Edgerton DS, Cherrington AD. Portal glucose infusion increases hepatic glycogen deposition in conscious unrestrained rats. J. Appl. Physiol. 1999 Oct; 87(4): 1470-5. PMID: 10517780, ISSN: 8750-7587.

Hsieh PS, Moore MC, Marshall B, Pagliassotti MJ, Shay B, Szurkus D, Neal DW, Cherrington AD. The head arterial glucose level is not the reference site for generation of the portal signal in conscious dogs. Am. J. Physiol. 1999 Oct; 277(4 Pt 1): E678-84. PMID: 10516127, ISSN: 0002-9513.

McGuinness OP, Snowden RT, Moran C, Neal DW, Fujiwara T, Cherrington AD. Impact of acute epinephrine removal on hepatic glucose metabolism during stress hormone infusion. Metab. Clin. Exp. 1999 Jul; 48(7): 910-4. PMID: 10421235, PII: S0026-0495(99)90228-7, ISSN: 0026-0495.

Galassetti P, Chu CA, Neal DW, Reed GW, Wasserman DH, Cherrington AD. A negative arterial-portal venous glucose gradient increases net hepatic glucose uptake in euglycemic dogs. Am. J. Physiol. 1999 Jul; 277(1 Pt 1): E126-34. PMID: 10409136, ISSN: 0002-9513.

Galassetti P, Coker RH, Lacy DB, Cherrington AD, Wasserman DH. Prior exercise increases net hepatic glucose uptake during a glucose load. Am. J. Physiol. 1999 Jun; 276(6 Pt 1): E1022-9. PMID: 10362614, ISSN: 0002-9513.

Moore MC, Lin DW, Colburn CA, Goldstein RE, Neal DW, Cherrington AD. Insulin- and glucagon-independent effects of calcitonin gene-related peptide in the conscious dog. Metab. Clin. Exp. 1999 May; 48(5): 603-10. PMID: 10337861, PII: S0026-0495(99)90058-6, ISSN: 0026-0495.

Cherrington AD. Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo. Diabetes. 1999 May; 48(5): 1198-214. PMID: 10331429, ISSN: 0012-1797.

Hsieh PS, Moore MC, Neal DW, Emshwiller M, Cherrington AD. Rapid reversal of the effects of the portal signal under hyperinsulinemic conditions in the conscious dog. Am. J. Physiol. 1999 May; 276(5 Pt 1): E930-7. PMID: 10329988, ISSN: 0002-9513.

Sindelar DK, Igawa K, Chu CA, Balcom JH, Neal DW, Cherrington AD. Effect of a selective rise in hepatic artery insulin on hepatic glucose production in the conscious dog. Am. J. Physiol. 1999 Apr; 276(4 Pt 1): E806-13. PMID: 10198319, ISSN: 0002-9513.

Galassetti P, Hamilton KS, Gibbons FK, Bracy DP, Lacy DB, Cherrington AD, Wasserman DH. Effect of fast duration on disposition of an intraduodenal glucose load in the conscious dog. Am. J. Physiol. 1999 Mar; 276(3 Pt 1): E543-52. PMID: 10070022, ISSN: 0002-9513.

Chu CA, Sindelar DK, Neal DW, Cherrington AD. Hepatic and gut clearance of catecholamines in the conscious dog. Metab. Clin. Exp. 1999 Feb; 48(2): 259-63. PMID: 10024092, PII: S0026-0495(99)90044-6, ISSN: 0026-0495.

Moore MC, Hsieh PS, Flakoll PJ, Neal DW, Cherrington AD. Differential effect of amino acid infusion route on net hepatic glucose uptake in the dog. Am. J. Physiol. 1999 Feb; 276(2 Pt 1): E295-302. PMID: 9950789, ISSN: 0002-9513.

Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J. Biol. Chem. 1999 Jan 1/1/1999; 274(1): 305-15. PMID: 9867845, ISSN: 0021-9258.

Hsieh PS, Moore MC, Neal DW, Cherrington AD. Hepatic glucose uptake rapidly decreases after removal of the portal signal in conscious dogs. Am. J. Physiol. 1998 Dec; 275(6 Pt 1): E987-92. PMID: 9843741, ISSN: 0002-9513.

Cherrington AD, Edgerton D, Sindelar DK. The direct and indirect effects of insulin on hepatic glucose production in vivo. Diabetologia. 1998 Sep; 41(9): 987-96. PMID: 9754815, DOI: 10.1007/s001250051021, ISSN: 0012-186X.

Galassetti P, Shiota M, Zinker BA, Wasserman DH, Cherrington AD. A negative arterial-portal venous glucose gradient decreases skeletal muscle glucose uptake. Am. J. Physiol. 1998 Jul; 275(1 Pt 1): E101-11. PMID: 9688880, ISSN: 0002-9513.

Galassetti P, Gibbons FK, Hamilton KS, Lacy DB, Cherrington AD, Wasserman DH. Enhanced muscle glucose uptake facilitates nitrogen efflux from exercised muscle. J. Appl. Physiol. 1998 Jun; 84(6): 1952-9. PMID: 9609789, ISSN: 8750-7587.

Shiota M, Galassetti P, Monohan M, Neal DW, Cherrington AD. Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog. Diabetes. 1998 Jun; 47(6): 867-73. PMID: 9604861, ISSN: 0012-1797.

Moore MC, Flakoll PJ, Hsieh PS, Pagliassotti MJ, Neal DW, Monohan MT, Venable C, Cherrington AD. Hepatic glucose disposition during concomitant portal glucose and amino acid infusions in the dog. Am. J. Physiol. 1998 May; 274(5 Pt 1): E893-902. PMID: 9612248, ISSN: 0002-9513.

Sindelar DK, Chu CA, Venson P, Donahue EP, Neal DW, Cherrington AD. Basal hepatic glucose production is regulated by the portal vein insulin concentration. Diabetes. 1998 Apr; 47(4): 523-9. PMID: 9568682, ISSN: 0012-1797.

Moore MC, Connolly CC, Cherrington AD. Autoregulation of hepatic glucose production. Eur. J. Endocrinol. 1998 Mar; 138(3): 240-8. PMID: 9539293, ISSN: 0804-4643.

Dobbins RL, Davis SN, Neal D, Caumo A, Cobelli C, Cherrington AD. Rates of glucagon activation and deactivation of hepatic glucose production in conscious dogs. Metab. Clin. Exp. 1998 Feb; 47(2): 135-42. PMID: 9472959, PII: S0026-0495(98)90209-8, ISSN: 0026-0495.

Chu CA, Sindelar DK, Neal DW, Allen EJ, Donahue EP, Cherrington AD. Effect of a selective rise in sinusoidal norepinephrine on HGP is due to an increase in glycogenolysis. Am. J. Physiol. 1998 Jan; 274(1 Pt 1): E162-71. PMID: 9458762, ISSN: 0002-9513.

Jackson PA, Pagliassotti MJ, Shiota M, Neal DW, Cardin S, Cherrington AD. Effects of vagal blockade on the counterregulatory response to insulin-induced hypoglycemia in the dog. Am. J. Physiol. 1997 Dec; 273(6 Pt 1): E1178-88. PMID: 9435534, ISSN: 0002-9513.

Sindelar DK, Chu CA, Neal DW, Cherrington AD. Interaction of equal increments in arterial and portal vein insulin on hepatic glucose production in the dog. Am. J. Physiol. 1997 Nov; 273(5 Pt 1): E972-80. PMID: 9374684, ISSN: 0002-9513.

Shiota M, Jackson PA, Bischoff H, McCaleb M, Scott M, Monohan M, Neal DW, Cherrington AD. Inhibition of glycogenolysis enhances gluconeogenic precursor uptake by the liver of conscious dogs. Am. J. Physiol. 1997 Nov; 273(5 Pt 1): E868-79. PMID: 9374671, ISSN: 0002-9513.

McGuinness OP, Shau V, Benson EM, Lewis M, Snowden RT, Greene JE, Neal DW, Cherrington AD. Role of epinephrine and norepinephrine in the metabolic response to stress hormone infusion in the conscious dog. Am. J. Physiol. 1997 Oct; 273(4 Pt 1): E674-81. PMID: 9357794, ISSN: 0002-9513.

Niswender KD, Shiota M, Postic C, Cherrington AD, Magnuson MA. Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. J. Biol. Chem. 1997 Sep 9/5/1997; 272(36): 22570-5. PMID: 9278411, ISSN: 0021-9258.

Holste LC, Connolly CC, Moore MC, Neal DW, Cherrington AD. Physiological changes in circulating glucagon alter hepatic glucose disposition during portal glucose delivery. Am. J. Physiol. 1997 Sep; 273(3 Pt 1): E488-96. PMID: 9316437, ISSN: 0002-9513.

Dunning BE, Scott MF, Neal DW, Cherrington AD. Direct quantification of norepinephrine spillover and hormone output from the pancreas of the conscious dog. Am. J. Physiol. 1997 May; 272(5 Pt 1): E746-55. PMID: 9176171, ISSN: 0002-9513.

Davis SN, Dunham B, Walmsley K, Shavers C, Neal D, Williams P, Cherrington AD. Brain of the conscious dog is sensitive to physiological changes in circulating insulin. Am. J. Physiol. 1997 Apr; 272(4 Pt 1): E567-75. PMID: 9142876, ISSN: 0002-9513.

Chu CA, Sindelar DK, Neal DW, Cherrington AD. Portal adrenergic blockade does not inhibit the gluconeogenic effects of circulating catecholamines on the liver. Metab. Clin. Exp. 1997 Apr; 46(4): 458-65. PMID: 9109855, ISSN: 0026-0495.

Chu CA, Sindelar DK, Neal DW, Allen EJ, Donahue EP, Cherrington AD. Comparison of the direct and indirect effects of epinephrine on hepatic glucose production. J. Clin. Invest. 1997 Mar 3/1/1997; 99(5): 1044-56. PMID: 9062363, PMCID: PMC507913, DOI: 10.1172/JCI119232, ISSN: 0021-9738.

Sindelar DK, Chu CA, Rohlie M, Neal DW, Swift LL, Cherrington AD. The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog. Diabetes. 1997 Feb; 46(2): 187-96. PMID: 9000693, ISSN: 0012-1797.

Balcom, J, Sindelar, D, Neal, D, Cherrington, AD. Troglitazone does not sensitize the liver to insulin in the normal dog. Diabetes Research. 1997; 32: 115-32.

Connolly CC, Myers SR, Neal DW, Hastings JR, Cherrington AD. In the absence of counterregulatory hormones, the increase in hepatic glucose production during insulin-induced hypoglycemia in the dog is initiated in the liver rather than the brain. Diabetes. 1996 Dec; 45(12): 1805-13. PMID: 8922369, ISSN: 0012-1797.

Sindelar DK, Balcom JH, Chu CA, Neal DW, Cherrington AD. A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes. 1996 Nov; 45(11): 1594-604. PMID: 8866566, ISSN: 0012-1797.

Moore MC, Rossetti L, Pagliassotti MJ, Monahan M, Venable C, Neal D, Cherrington AD. Neural and pancreatic influences on net hepatic glucose uptake and glycogen synthesis. Am. J. Physiol. 1996 Aug; 271(2 Pt 1): E215-22. PMID: 8770013, ISSN: 0002-9513.

Chu CA, Sindelar DK, Neal DW, Cherrington AD. Direct effects of catecholamines on hepatic glucose production in conscious dog are due to glycogenolysis. Am. J. Physiol. 1996 Jul; 271(1 Pt 1): E127-37. PMID: 8760090, ISSN: 0002-9513.

Hamilton KS, Gibbons FK, Bracy DP, Lacy DB, Cherrington AD, Wasserman DH. Effect of prior exercise on the partitioning of an intestinal glucose load between splanchnic bed and skeletal muscle. J. Clin. Invest. 1996 Jul 7/1/1996; 98(1): 125-35. PMID: 8690783, PMCID: PMC507408, DOI: 10.1172/JCI118756, ISSN: 0021-9738.

Wang DZ, Cherrington A, Famakin-Mosuro B, Boothby M. Independent pathways for de-repression of the mouse Ig heavy chain germ-line epsilon promoter: an IL-4 NAF/NF-IL-4 site as a context-dependent negative element. Int. Immunol. 1996 Jul; 8(7): 977-89. PMID: 8757943, ISSN: 0953-8178.

Fujiwara T, Cherrington AD, Neal DN, McGuinness OP. Role of cortisol in the metabolic response to stress hormone infusion in the conscious dog. Metab. Clin. Exp. 1996 May; 45(5): 571-8. PMID: 8622599, PII: S0026-0495(96)90026-8, ISSN: 0026-0495.

Donnelly JE, Jacobsen DJ, Whatley JE, Hill JO, Swift LL, Cherrington A, Polk B, Tran ZV, Reed G. Nutrition and physical activity program to attenuate obesity and promote physical and metabolic fitness in elementary school children. Obes. Res. 1996 May; 4(3): 229-43. PMID: 8732957, ISSN: 1071-7323.

Shiota M, Green R, Colburn CA, Mitchell G, Cherrington AD. Inability of hyperglycemia to counter the ability of glucagon to increase net glucose output and activate glycogen phosphorylase in the perfused rat liver. Metab. Clin. Exp. 1996 Apr; 45(4): 481-5. PMID: 8609835, ISSN: 0026-0495.

Moore MC, Cherrington AD. The nerves, the liver, and the route of feeding: an integrated response to nutrient delivery [editorial]. Nutrition. 1996 Apr; 12(4): 282-4. PMID: 8862538, PII: S0899900797850734, ISSN: 0899-9007.

Connolly CC, Ivy RE, Adkins-Marshall BA, Dobbins RL, Neal DW, Williams PE, Cherrington AD. Counterregulation by epinephrine and glucagon during insulin-induced hypoglycemia in the conscious dog. Diabetes Res. Clin. Pract. 1996 Mar; 31(1-3): 45-56. PMID: 8792101, ISSN: 0168-8227.

Moore MC, Cherrington AD. Regulation of net hepatic glucose uptake: interaction of neural and pancreatic mechanisms. Reprod. Nutr. Dev. 1996; 36(4): 399-406. PMID: 8878357, PII: 0926528796819794, ISSN: 0926-5287.

Pagliassotti MJ, Holste LC, Moore MC, Neal DW, Cherrington AD. Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J. Clin. Invest. 1996 Jan 1/1/1996; 97(1): 81-91. PMID: 8550854, PMCID: PMC507065, DOI: 10.1172/JCI118410, ISSN: 0021-9738.

Goldstein RE, Abumrad NN, Lacy DB, Wasserman DH, Cherrington AD. Effects of an acute increase in epinephrine and cortisol on carbohydrate metabolism during insulin deficiency. Diabetes. 1995 Jun; 44(6): 672-81. PMID: 7789632, ISSN: 0012-1797.

Dobbins RL, Davis SN, Neal DW, Cobelli C, Jaspan J, Cherrington AD. Compartmental modeling of glucagon kinetics in the conscious dog. Metab. Clin. Exp. 1995 Apr; 44(4): 452-9. PMID: 7723667, PII: 0026-0495(95)90051-9, ISSN: 0026-0495.

Davis SN, Dobbins R, Tarumi C, Jacobs J, Neal D, Cherrington AD. Paradoxical insulin-induced increase in gluconeogenesis in response to prolonged hypoglycemia in conscious dogs. Am. J. Physiol. 1995 Mar; 268(3 Pt 1): E521-30. PMID: 7900798, ISSN: 0002-9513.

Wada M, Connolly CC, Tarumi C, Neal DW, Cherrington AD. Hepatic denervation does not significantly change the response of the liver to glucagon in conscious dogs. Am. J. Physiol. 1995 Feb; 268(2 Pt 1): E194-203. PMID: 7864094, ISSN: 0002-9513.

Davis SN, Colburn C, Dobbins R, Nadeau S, Neal D, Williams P, Cherrington AD. Evidence that the brain of the conscious dog is insulin sensitive. J. Clin. Invest. 1995 Feb; 95(2): 593-602. PMID: 7860743, PMCID: PMC295522, DOI: 10.1172/JCI117703, ISSN: 0021-9738.

McGuinness OP, Murrell S, Moran C, Bracy D, Cherrington AD. The effect of acute glucagon removal on the metabolic response to stress hormone infusion in the conscious dog. Metab. Clin. Exp. 1994 Oct; 43(10): 1310-7. PMID: 7934986, PII: 0026-0495(94)90228-3, ISSN: 0026-0495.

Davis SN, Shavers C, Collins L, Cherrington AD, Price L, Hedstrom C. Effects of physiological hyperinsulinemia on counterregulatory response to prolonged hypoglycemia in normal humans. Am. J. Physiol. 1994 Sep; 267(3 Pt 1): E402-10. PMID: 7943220, ISSN: 0002-9513.

Cherrington AD, Wasserman DH, McGinness OP. Renal contribution to glucose production after a brief fast: fact or fancy? [editorial]. J. Clin. Invest. 1994 Jun; 93(6): 2303. PMID: 8200961, PMCID: PMC294432, DOI: 10.1172/JCI117232, ISSN: 0021-9738.

Moore MC, Pagliassotti MJ, Goldstein RE, Asher J, Murrell J, Neal D, Cherrington AD. The effect of the hepatic nerves on the disposition of a mixed meal by conscious dogs. JPEN J Parenter Enteral Nutr. 1994 May; 18(3): 248-55. PMID: 8065001, ISSN: 0148-6071.

Moore MC, Pagliassotti MJ, Swift LL, Asher J, Murrell J, Neal D, Cherrington AD. Disposition of a mixed meal by the conscious dog. Am. J. Physiol. 1994 Apr; 266(4 Pt 1): E666-75. PMID: 8178989, ISSN: 0002-9513.

Goldstein RE, Cherrington AD, Reed GW, Lacy DB, Wasserman DH, Abumrad NN. Effects of chronic hypercortisolemia on carbohydrate metabolism during insulin deficiency. Am. J. Physiol. 1994 Apr; 266(4 Pt 1): E618-27. PMID: 8178983, ISSN: 0002-9513.

Dobbins RL, Davis SN, Neal DW, Cobelli C, Cherrington AD. Pulsatility does not alter the response to a physiological increment in glucagon in the conscious dog. Am. J. Physiol. 1994 Mar; 266(3 Pt 1): E467-78. PMID: 8166269, ISSN: 0002-9513.

McGuinness OP, Burgin K, Moran C, Bracy D, Cherrington AD. Role of glucagon in the metabolic response to stress hormone infusion in the conscious dog. Am. J. Physiol. 1994 Mar; 266(3 Pt 1): E438-47. PMID: 8166265, ISSN: 0002-9513.

Davis SN, Goldstein RE, Cherrington AD, Price L. Exaggerated epinephrine response to hypoglycemia in a physically fit, well-controlled IDDM subject. Diabetes Res. Clin. Pract. 1994 Jan; 22(2-3): 139-46. PMID: 8200295, ISSN: 0168-8227.

Goldstein RE, Wasserman DH, Reed GW, Lacy DB, Abumrad NN, Cherrington AD. The effects of acute hypercortisolemia on beta-hydroxybutyrate and glycerol metabolism during insulin deficiency. Horm. Metab. Res. 1994 Jan; 26(1): 9-13. PMID: 7908656, DOI: 10.1055/s-2007-1000764, ISSN: 0018-5043.

Davis SN, Cherrington AD, Goldstein RE, Jacobs J, Price L. Effects of insulin on the counterregulatory response to equivalent hypoglycemia in normal females. Am. J. Physiol. 1993 Nov; 265(5 Pt 1): E680-9. PMID: 8238493, ISSN: 0002-9513.

Davis SN, Goldstein RE, Price L, Jacobs J, Cherrington AD. The effects of insulin on the counterregulatory response to equivalent hypoglycemia in patients with insulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 1993 Nov; 77(5): 1300-7. PMID: 8077324, DOI: 10.1210/jcem.77.5.8077324, ISSN: 0021-972X.

Moore MC, Pagliassotti MJ, Wasserman DH, Goldstein R, Asher J, Neal DW, Cherrington AD. Hepatic denervation alters the transition from the fed to the food-deprived state in conscious dogs. J. Nutr. 1993 Oct; 123(10): 1739-46. PMID: 8410366, ISSN: 0022-3166.

Frizzell RT, Jones EM, Davis SN, Biggers DW, Myers SR, Connolly CC, Neal DW, Jaspan JB, Cherrington AD. Counterregulation during hypoglycemia is directed by widespread brain regions. Diabetes. 1993 Sep; 42(9): 1253-61. PMID: 8349036, ISSN: 0012-1797.

Moore MC, Shulman GI, Giaccari A, Pagliassotti MJ, Cline G, Neal D, Rossetti L, Cherrington AD. Effect of hepatic nerves on disposition of an intraduodenal glucose load. Am. J. Physiol. 1993 Sep; 265(3 Pt 1): E487-96. PMID: 8214056, ISSN: 0002-9513.

McGuinness OP, Fugiwara T, Murrell S, Bracy D, Neal D, O'Connor D, Cherrington AD. Impact of chronic stress hormone infusion on hepatic carbohydrate metabolism in the conscious dog. Am. J. Physiol. 1993 Aug; 265(2 Pt 1): E314-22. PMID: 8368302, ISSN: 0002-9513.

Davis SN, Dobbins R, Colburn C, Tarumi C, Jacobs J, Neal D, Cherrington AD. Effects of hyperinsulinemia on the subsequent hormonal response to hypoglycemia in conscious dogs. Am. J. Physiol. 1993 May; 264(5 Pt 1): E748-55. PMID: 8498496, ISSN: 0002-9513.

Connolly CC, Stevenson RW, Neal DW, Wasserman DH, Cherrington AD. The effects of lactate loading on alanine and glucose metabolism in the conscious dog. Metab. Clin. Exp. 1993 Feb; 42(2): 154-61. PMID: 8474311, ISSN: 0026-0495.

Davis SN, Goldstein RE, Jacobs J, Price L, Wolfe R, Cherrington AD. The effects of differing insulin levels on the hormonal and metabolic response to equivalent hypoglycemia in normal humans. Diabetes. 1993 Feb; 42(2): 263-72. PMID: 8425662, ISSN: 0012-1797.

Goldstein RE, Wasserman DH, McGuinness OP, Lacy DB, Cherrington AD, Abumrad NN. Effects of chronic elevation in plasma cortisol on hepatic carbohydrate metabolism. Am. J. Physiol. 1993 Jan; 264(1 Pt 1): E119-27. PMID: 8430780, ISSN: 0002-9513.

Davis SN, Cherrington AD. The hormonal and metabolic responses to prolonged hypoglycemia. J. Lab. Clin. Med. 1993 Jan; 121(1): 21-31. PMID: 8426079, PII: 0022-2143(93)90220-S, ISSN: 0022-2143.

Cherrington AD, Stevenson RW, Steiner KE, Connolly CC, Wada M, Goldstein RE. Acute hormonal regulation of gluconeogenesis in the conscious dog. Adv. Exp. Med. Biol. 1993; 334: 199-208. PMID: 8249683, ISSN: 0065-2598.

Pagliassotti MJ, Colburn CA, Moore MC, Neal DW, Dominianni SJ, Stephens TW, Cherrington AD. Regulation of net hepatic substrate balance by phenacylimidazolium ions in the conscious dog. Diabetes Res. 1993; 22(3): 123-33. PMID: 7915646, ISSN: 0265-5985.

Myers, S, Ivy, R, Cherrington, AD, Diamond, MP. Effect of norgestrel on intermediary metabolism in the conscious dog. Endocrine Journal. 1993; 1: 93-9.

Goldstein RE, Reed GW, Wasserman DH, Williams PE, Lacy DB, Buckspan R, Abumrad NN, Cherrington AD. The effects of acute elevations in plasma cortisol levels on alanine metabolism in the conscious dog. Metab. Clin. Exp. 1992 Dec; 41(12): 1295-303. PMID: 1461135, ISSN: 0026-0495.

Davis SN, Dobbins R, Tarumi C, Colburn C, Neal D, Cherrington AD. Effects of differing insulin levels on response to equivalent hypoglycemia in conscious dogs. Am. J. Physiol. 1992 Oct; 263(4 Pt 1): E688-95. PMID: 1415687, ISSN: 0002-9513.

Connolly CC, Adkins-Marshall BA, Neal DW, Pugh W, Jaspan JB, Cherrington AD. Relationship between decrements in glucose level and metabolic response to hypoglycemia in absence of counterregulatory hormones in the conscious dog. Diabetes. 1992 Oct; 41(10): 1308-19. PMID: 1397705, ISSN: 0012-1797.

Pagliassotti MJ, Moore MC, Neal DW, Cherrington AD. Insulin is required for the liver to respond to intraportal glucose delivery in the conscious dog. Diabetes. 1992 Oct; 41(10): 1247-56. PMID: 1397697, ISSN: 0012-1797.

Hendrick GK, Wasserman DH, Frizzell RT, Williams PE, Lacy DB, Jaspan JB, Cherrington AD. Importance of basal glucagon in maintaining hepatic glucose production during a prolonged fast in conscious dogs. Am. J. Physiol. 1992 Sep; 263(3 Pt 1): E541-9. PMID: 1415534, ISSN: 0002-9513.

Adkins-Marshall B, Pagliassotti MJ, Asher JR, Connolly CC, Neal DW, Williams PE, Myers SR, Hendrick GK, Adkins RB, Cherrington AD. Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs. Am. J. Physiol. 1992 May; 262(5 Pt 1): E679-86. PMID: 1590377, ISSN: 0002-9513.

Pagliassotti MJ, Cherrington AD. Regulation of net hepatic glucose uptake in vivo. Annu. Rev. Physiol. 1992; 54: 847-60. PMID: 1562194, DOI: 10.1146/annurev.ph.54.030192.004215, ISSN: 0066-4278.

Dobbins RL, Connolly CC, Neal DW, Palladino LJ, Parlow AF, Cherrington AD. Role of glucagon in countering hypoglycemia induced by insulin infusion in dogs. Am. J. Physiol. 1991 Dec; 261(6 Pt 1): E773-81. PMID: 1767838, ISSN: 0002-9513.

Connolly CC, Steiner KE, Stevenson RW, Neal DW, Williams PE, Alberti KG, Cherrington AD. Regulation of glucose metabolism by norepinephrine in conscious dogs. Am. J. Physiol. 1991 Dec; 261(6 Pt 1): E764-72. PMID: 1767837, ISSN: 0002-9513.

Pagliassotti MJ, Myers SR, Moore MC, Neal DW, Cherrington AD. Magnitude of negative arterial-portal glucose gradient alters net hepatic glucose balance in conscious dogs. Diabetes. 1991 Dec; 40(12): 1659-68. PMID: 1684554, ISSN: 0012-1797.

Wasserman DH, Lacy DB, Colburn CA, Bracy D, Cherrington AD. Efficiency of compensation for absence of fall in insulin during exercise. Am. J. Physiol. 1991 Nov; 261(5 Pt 1): E587-97. PMID: 1951683, ISSN: 0002-9513.

Steiner KE, Stevenson RW, Adkins-Marshall BA, Cherrington AD. The effects of epinephrine on ketogenesis in the dog after a prolonged fast. Metab. Clin. Exp. 1991 Oct; 40(10): 1057-62. PMID: 1943732, ISSN: 0026-0495.

Connolly CC, Steiner KE, Stevenson RW, Neal DW, Williams PE, Alberti KG, Cherrington AD. Regulation of lipolysis and ketogenesis by norepinephrine in conscious dogs. Am. J. Physiol. 1991 Oct; 261(4 Pt 1): E466-72. PMID: 1928338, ISSN: 0002-9513.

Moore MC, Cherrington AD, Cline G, Pagliassotti MJ, Jones EM, Neal DW, Badet C, Shulman GI. Sources of carbon for hepatic glycogen synthesis in the conscious dog. J. Clin. Invest. 1991 Aug; 88(2): 578-87. PMID: 1864968, PMCID: PMC295390, DOI: 10.1172/JCI115342, ISSN: 0021-9738.

Pagliassotti MJ, Tarumi C, Neal DW, Cherrington AD. Hepatic denervation alters the disposition of an enteral glucose load in conscious dogs. J. Nutr. 1991 Aug; 121(8): 1255-61. PMID: 1861174, ISSN: 0022-3166.

Myers SR, Biggers DW, Neal DW, Cherrington AD. Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo. J. Clin. Invest. 1991 Jul; 88(1): 158-67. PMID: 2056115, PMCID: PMC296016, DOI: 10.1172/JCI115273, ISSN: 0021-9738.

Wasserman DH, Cherrington AD. Hepatic fuel metabolism during muscular work: role and regulation [editorial]. Am. J. Physiol. 1991 Jun; 260(6 Pt 1): E811-24. PMID: 2058658, ISSN: 0002-9513.

Cherrington AD, Pagliassotti MJ, Myers SR, Adkins-Marshall B, McGuinness OP. Factors which regulate net hepatic glucose uptake in vivo. JPEN J Parenter Enteral Nutr. 1991 May; 15(3): 71S-73S. PMID: 1865561, ISSN: 0148-6071.

Stevenson RW, Steiner KE, Connolly CC, Fuchs H, Alberti KG, Williams PE, Cherrington AD. Dose-related effects of epinephrine on glucose production in conscious dogs. Am. J. Physiol. 1991 Mar; 260(3 Pt 1): E363-70. PMID: 2003590, ISSN: 0002-9513.

Myers SR, McGuinness OP, Neal DW, Cherrington AD. Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. J. Clin. Invest. 1991 Mar; 87(3): 930-9. PMID: 1999501, PMCID: PMC329884, DOI: 10.1172/JCI115100, ISSN: 0021-9738.

Frizzell RT, Meyer YJ, Borchers DJ, Weprin BE, Allen EC, Pogue WR, Reisch JS, Cherrington AD, Batjer HH. The effects of etomidate on cerebral metabolism and blood flow in a canine model for hypoperfusion. J. Neurosurg. 1991 Feb; 74(2): 263-9. PMID: 1988597, DOI: 10.3171/jns.1991.74.2.0263, ISSN: 0022-3085.

Myers SR, Diamond MP, Adkins-Marshall BA, Williams PE, Stinsen R, Cherrington AD. Effects of small changes in glucagon on glucose production during a euglycemic, hyperinsulinemic clamp. Metab. Clin. Exp. 1991 Jan; 40(1): 66-71. PMID: 1984573, PII: 0026-0495(91)90194-2, ISSN: 0026-0495.

Cherrington AD, Frizzell RT, Biggers DW, Connolly CC. Hypoglycemia, gluconeogenesis and the brain. Adv. Exp. Med. Biol. 1991; 291: 197-211. PMID: 1927682, ISSN: 0065-2598.

Steiner KE, Williams PE, Lacy WW, Cherrington AD. Effects of insulin on glucagon-stimulated glucose production in the conscious dog. Metab. Clin. Exp. 1990 Dec; 39(12): 1325-33. PMID: 2246975, ISSN: 0026-0495.

McGuinness OP, Myers SR, Neal D, Cherrington AD. Chronic hyperinsulinemia decreases insulin action but not insulin sensitivity. Metab. Clin. Exp. 1990 Sep; 39(9): 931-7. PMID: 2202884, PII: 0026-0495(90)90303-T, ISSN: 0026-0495.

McGuinness OP; discussion 51S-53S, Cherrington AD. Effect of glyburide on hepatic glucose metabolism. Am. J. Med. 1990 Aug 8/20/1990; 89(2A): 26S-37S. PMID: 2117387, ISSN: 0002-9343.

Wasserman DH, Williams PE, Lacy DB, Bracy D, Cherrington AD. Hepatic nerves are not essential to the increase in hepatic glucose production during muscular work. Am. J. Physiol. 1990 Aug; 259(2 Pt 1): E195-203. PMID: 2200275, ISSN: 0002-9513.

Hendrick GK, Frizzell RT, Williams PE, Cherrington AD. Effect of hyperglucagonemia on hepatic glycogenolysis and gluconeogenesis after a prolonged fast. Am. J. Physiol. 1990 May; 258(5 Pt 1): E841-9. PMID: 2185665, ISSN: 0002-9513.

McGuinness OP, Friedman A, Cherrington AD. Intraportal hyperinsulinemia decreases insulin-stimulated glucose uptake in the dog. Metab. Clin. Exp. 1990 Feb; 39(2): 127-32. PMID: 2405232, PII: 0026-0495(90)90064-J, ISSN: 0026-0495.

Adkins-Marshall BA, Myers SR, Hendrick GK, Williams PE, Triebwasser K, Floyd B, Cherrington AD. Interaction between insulin and glucose-delivery route in regulation of net hepatic glucose uptake in conscious dogs. Diabetes. 1990 Jan; 39(1): 87-95. PMID: 2210065, ISSN: 0012-1797.

Cryer PE, Binder C, Bolli GB, Cherrington AD, Gale EA, Gerich JE, Sherwin RS. Hypoglycemia in IDDM. Diabetes. 1989 Sep; 38(9): 1193-9. PMID: 2767340, ISSN: 0012-1797.

Wasserman DH, Spalding JA, Lacy DB, Colburn CA, Goldstein RE, Cherrington AD. Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work. Am. J. Physiol. 1989 Jul; 257(1 Pt 1): E108-17. PMID: 2665514, ISSN: 0002-9513.

Wasserman DH, Spalding JA, Bracy D, Lacy DB, Cherrington AD. Exercise-induced rise in glucagon and ketogenesis during prolonged muscular work. Diabetes. 1989 Jun; 38(6): 799-807. PMID: 2566546, ISSN: 0012-1797.

Wasserman DH, Williams PE, Lacy DB, Goldstein RE, Cherrington AD. Exercise-induced fall in insulin and hepatic carbohydrate metabolism during muscular work. Am. J. Physiol. 1989 Apr; 256(4 Pt 1): E500-9. PMID: 2650562, ISSN: 0002-9513.

Wasserman DH, Lacy DB, Goldstein RE, Williams PE, Cherrington AD. Exercise-induced fall in insulin and increase in fat metabolism during prolonged muscular work. Diabetes. 1989 Apr; 38(4): 484-90. PMID: 2647555, ISSN: 0012-1797.

Biggers DW, Myers SR, Neal D, Stinson R, Cooper NB, Jaspan JB, Williams PE, Cherrington AD, Frizzell RT. Role of brain in counterregulation of insulin-induced hypoglycemia in dogs. Diabetes. 1989 Jan; 38(1): 7-16. PMID: 2642436, ISSN: 0012-1797.

Frizzell RT, Hendrick GK, Brown LL, Lacy DB, Donahue EP, Carr RK, Williams PE, Parlow AF, Stevenson RW, Cherrington AD. Stimulation of glucose production through hormone secretion and other mechanisms during insulin-induced hypoglycemia. Diabetes. 1988 Nov; 37(11): 1531-41. PMID: 3053302, ISSN: 0012-1797.

Moates JM, Lacy DB, Goldstein RE, Cherrington AD, Wasserman DH. Metabolic role of the exercise-induced increment in epinephrine in the dog. Am. J. Physiol. 1988 Oct; 255(4 Pt 1): E428-36. PMID: 3052103, ISSN: 0002-9513.

Diamond MP, Wentz AC, Cherrington AD. Alterations in carbohydrate metabolism as they apply to reproductive endocrinology. Fertil. Steril. 1988 Sep; 50(3): 387-97. PMID: 3044841, ISSN: 0015-0282.

Frizzell RT, Hendrick GK, Biggers DW, Lacy DB, Donahue DP, Green DR, Carr RK, Williams PE, Stevenson RW, Cherrington AD. Role of gluconeogenesis in sustaining glucose production during hypoglycemia caused by continuous insulin infusion in conscious dogs. Diabetes. 1988 Jun; 37(6): 749-59. PMID: 3289995, ISSN: 0012-1797.

Stevenson RW, Stebbing N, Jones T, Carr K, Jones PM, Hii C, Cherrington AD. The synthetic human growth hormone fragment (32-38) increases glucose uptake in the conscious dog. Acta Endocrinol. 1988 Apr; 117(4): 457-62. PMID: 3291525, ISSN: 0001-5598.

Wasserman DH, Williams PE, Lacy DB, Green DR, Cherrington AD. Importance of intrahepatic mechanisms to gluconeogenesis from alanine during exercise and recovery. Am. J. Physiol. 1988 Apr; 254(4 Pt 1): E518-25. PMID: 3281473, ISSN: 0002-9513.

Frizzell RT, Campbell PJ, Cherrington AD. Gluconeogenesis and hypoglycemia. Diabetes Metab Rev. 1988 Feb; 4(1): 51-70. PMID: 3278874, ISSN: 0742-4221.

Diamond MP, Rollings RC, Steiner KE, Williams PE, Lacy WW, Cherrington AD. Effect of alanine concentration independent of changes in insulin and glucagon on alanine and glucose homeostasis in the conscious dog. Metab. Clin. Exp. 1988 Jan; 37(1): 28-33. PMID: 3275858, PII: 0026-0495(88)90025-X, ISSN: 0026-0495.

Cherrington AD, Stevenson RW, Steiner KE. Glucagon as a regulator of hepatic glucose production in vivo. Biochem. Soc. Trans. 1987 Dec; 15(6): 1023-7. PMID: 3446548, ISSN: 0300-5127.

Wasserman DH, Lacy DB, Green DR, Williams PE, Cherrington AD. Dynamics of hepatic lactate and glucose balances during prolonged exercise and recovery in the dog. J. Appl. Physiol. 1987 Dec; 63(6): 2411-7. PMID: 3325489, ISSN: 8750-7587.

Hendrick GK, Frizzell RT, Cherrington AD. Effect of somatostatin on nonesterified fatty acid levels modifies glucose homeostasis during fasting. Am. J. Physiol. 1987 Oct; 253(4 Pt 1): E443-52. PMID: 2889364, ISSN: 0002-9513.

Stevenson RW, Steiner KE, Hendrick GK, Cherrington AD. Effect of somatostatin on glucose homeostasis in conscious long-fasted dogs. Am. J. Physiol. 1987 Oct; 253(4 Pt 1): E435-42. PMID: 2889363, ISSN: 0002-9513.

Stevenson RW, Williams PE, Cherrington AD. Role of glucagon suppression on gluconeogenesis during insulin treatment of the conscious diabetic dog. Diabetologia. 1987 Oct; 30(10): 782-90. PMID: 3322904, ISSN: 0012-186X.

Davis MA, Williams PE, Cherrington AD. Net hepatic lactate balance following mixed meal feeding in the four-day fasted conscious dog. Metab. Clin. Exp. 1987 Sep; 36(9): 856-62. PMID: 3306279, PII: 0026-0495(87)90094-1, ISSN: 0026-0495.

Stevenson RW, Mitchell DR, Hendrick GK, Rainey R, Cherrington AD, Frizzell RT. Lactate as substrate for glycogen resynthesis after exercise. J. Appl. Physiol. 1987 Jun; 62(6): 2237-40. PMID: 3610920, ISSN: 8750-7587.

Stevenson RW, Steiner KE, Williams PE, Cherrington AD. Lack of effect of somatostatin on epinephrine-stimulated glucose production in the dog. Metab. Clin. Exp. 1987 May; 36(5): 451-7. PMID: 2883556, PII: 0026-0495(87)90042-4, ISSN: 0026-0495.

Stevenson RW, Stebbing N, Rudman CG, Williams PE, Cherrington AD. The synthetic 32-46 fragment of human growth hormone increases insulin and glucagon levels in the conscious dog. Metab. Clin. Exp. 1987 Apr; 36(4): 400-4. PMID: 3550377, ISSN: 0026-0495.

McGuinness OP, Green DR, Cherrington AD. Glyburide sensitizes perfused rat liver to insulin-induced suppression of glucose output. Diabetes. 1987 Apr; 36(4): 472-6. PMID: 3102299, ISSN: 0012-1797.

Cohen RM, Licinio J, Polonsky KS, Galloway JA, Frank BH, Cherrington AD, Rubenstein AH. The effect of biosynthetic human proinsulin on the hepatic response to glucagon in insulin-deficient diabetes. J. Clin. Endocrinol. Metab. 1987 Mar; 64(3): 476-81. PMID: 3546347, DOI: 10.1210/jcem-64-3-476, ISSN: 0021-972X.

Stevenson RW, Steiner KE, Davis MA, Hendrick GK, Williams PE, Lacy WW, Brown L, Donahue P, Lacy DB, Cherrington AD. Similar dose responsiveness of hepatic glycogenolysis and gluconeogenesis to glucagon in vivo. Diabetes. 1987 Mar; 36(3): 382-9. PMID: 2879758, ISSN: 0012-1797.

Adkins BA, Myers SR, Hendrick GK, Stevenson RW, Williams PE, Cherrington AD. Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog. J. Clin. Invest. 1987 Feb; 79(2): 557-65. PMID: 2879854, PMCID: PMC424126, DOI: 10.1172/JCI112847, ISSN: 0021-9738.

Cherrington AD, Stevenson RW, Steiner KE, Davis MA, Myers SR, Adkins BA, Abumrad NN, Williams PE. Insulin, glucagon, and glucose as regulators of hepatic glucose uptake and production in vivo. Diabetes Metab Rev. 1987 Jan; 3(1): 307-32. PMID: 3552525, ISSN: 0742-4221.

Goldstein, R, Wasserman, D, Williams, PE, Lacy, BS, Carr, K, Cherrington, A, Abumrad, NN. Metabolic effects of epinephrine during chronic hypercortisolemia. Surgical Forum. 1987; 38: 1-4.

Steiner KE, Mouton SM, Williams PE, Lacy WW, Cherrington AD. Relative importance of first- and second-phase insulin secretion in glucose homeostasis in conscious dog. II. Effects on gluconeogenesis. Diabetes. 1986 Jul; 35(7): 776-84. PMID: 3522319, ISSN: 0012-1797.

Goldstein, R, Steed, M, Williams, P, Abumrad, N, Cherrington, A. Catabolic effects of chronic hypercotisolemia during insulin deficiency. Surgical Forum. 1986; 37: 15-8.

Steiner KE, Stevenson RW, Green DR, Cherrington AD. Mechanism of epinephrine's glycogenolytic effect in isolated canine hepatocytes. Metab. Clin. Exp. 1985 Nov; 34(11): 1020-3. PMID: 4058306, PII: 0026-0495(85)90073-3, ISSN: 0026-0495.

Stevenson RW, Cherrington AD, Steiner KE. The relationship between plasma concentration and disappearance rate of immunoreactive insulin in the conscious dog. Horm. Metab. Res. 1985 Nov; 17(11): 551-3. PMID: 3908265, DOI: 10.1055/s-2007-1013604, ISSN: 0018-5043.

Steiner KE, Fuchs H, Williams PE, Stevenson RW, Cherrington AD, Alberti KG. Regulation of ketogenesis by epinephrine and norepinephrine in the overnight-fasted, conscious dog. Diabetes. 1985 May; 34(5): 425-32. PMID: 3886459, ISSN: 0012-1797.

Davis MA, Williams PE, Cherrington AD. Effect of glucagon on hepatic lactate metabolism in the conscious dog. Am. J. Physiol. 1985 Apr; 248(4 Pt 1): E463-70. PMID: 2858980, ISSN: 0002-9513.

Pilkis, SJ, Regen, DM, Claus, TH, Cherrington, AD. Role of hepatic glycolysis and gluconeogenesis in glycogen synthesis. BioEssays. 1985; 2((6)): 273-4.

Radosevich PM, Williams PE, Lacy DB, McRae JR, Steiner KE, Cherrington AD, Lacy WW, Abumrad NN. Effects of morphine on glucose homeostasis in the conscious dog. J. Clin. Invest. 1984 Oct; 74(4): 1473-80. PMID: 6148357, PMCID: PMC425317, DOI: 10.1172/JCI111560, ISSN: 0021-9738.

Davis MA, Williams PE, Cherrington AD. Effect of a mixed meal on hepatic lactate and gluconeogenic precursor metabolism in dogs. Am. J. Physiol. 1984 Sep; 247(3 Pt 1): E362-9. PMID: 6383070, ISSN: 0002-9513.

Stevenson RW, Steiner KE, Green DR, Cherrington AD. Lack of effect of somatostatin on the stimulation of hepatic glycogenolysis by epinephrine in isolated canine hepatocytes. Biochim. Biophys. Acta. 1984 Aug 8/17/1984; 804(4): 414-8. PMID: 6432062, ISSN: 0006-3002.

Cherrington AD, Fuchs H, Stevenson RW, Williams PE, Alberti KG, Steiner KE. Effect of epinephrine on glycogenolysis and gluconeogenesis in conscious overnight-fasted dogs. Am. J. Physiol. 1984 Aug; 247(2 Pt 1): E137-44. PMID: 6380303, ISSN: 0002-9513.

Bergenstal, RM, Cohen, RM, Lever, CE, Polonsky, K, Jaspan, J, Blix, P, Revers, R, Olefsky, JM, Kolterman, O, Steiner, K, Cherrington, A, Frank, B, Galloway, J, Rubenstein, AH. The metabolic effects of biosynthetic human proinsulin in individuals with type I diabetes. J Clin Endo Meta. 1984; 56((6)): 973-9.

Cherrington AD, Lacy WW, Williams PE, Steiner KE. Failure of somatostatin to modify effect of glucagon on carbohydrate metabolism in the dog. Am. J. Physiol. 1983 Jun; 244(6): E596-602. PMID: 6134474, ISSN: 0002-9513.

Steiner KE, Mouton SM, Bowles CR, Williams PE, Cherrington AD. The relative importance of first- and second-phase insulin secretion in countering the action of glucagon on glucose turnover in the conscious dog. Diabetes. 1982 Nov; 31(11): 964-72. PMID: 6757015, ISSN: 0012-1797.

Abumrad NN, Jefferson LS, Rannels SR, Williams PE, Cherrington AD, Lacy WW. Role of insulin in the regulation of leucine kinetics in the conscious dog. J. Clin. Invest. 1982 Nov; 70(5): 1031-41. PMID: 6127347, PMCID: PMC370315, ISSN: 0021-9738.

Cherrington AD, Diamond MP, Green DR, Williams PE. Evidence for an intrahepatic contribution to the waning effect of glucagon on glucose production in the conscious dog. Diabetes. 1982 Oct; 31(10): 917-22. PMID: 6759225, ISSN: 0012-1797.

Cherrington AD, Steiner KE. The effects of insulin on carbohydrate metabolism in vivo. Clin Endocrinol Metab. 1982 Jul; 11(2): 307-28. PMID: 6754160, ISSN: 0300-595X.

Abumrad NN, Cherrington AD, Williams PE, Lacy WW, Rabin D. Absorption and disposition of a glucose load in the conscious dog. Am. J. Physiol. 1982 Jun; 242(6): E398-406. PMID: 7046460, ISSN: 0002-9513.

Diamond MP, Suhrer JH, Williams PE, Lacy WW, Cherrington AD. Contribution of the liver and extrasplanchnic tissues to the hypoglycemic action of dichloroacetate in the conscious dog. Diabetes. 1982 Apr; 31(4 Pt 1): 326-32. PMID: 6130020, ISSN: 0012-1797.

Cherrington AD, Williams PE, Abou-Mourad N, Lacy WW, Steiner KE, Liljenquist JE. Insulin as a mediator of hepatic glucose uptake in the conscious dog. Am. J. Physiol. 1982 Feb; 242(2): E97-101. PMID: 7039339, ISSN: 0002-9513.

Diamond MP, Suhrer JH, Williams PE, Cherrington AD. Dichloroacetate: direct inhibitor of lipolysis in the conscious dog. Horm. Metab. Res. 1982 Feb; 14(2): 102-3. PMID: 6121746, DOI: 10.1055/s-2007-1018936, ISSN: 0018-5043.

Liljenquist JE, Lewis SB, Cherrington AD, Sinclair-Smith BC, Lacy WW. Effects of pharmacologic hyperglucagonemia on plasma amino acid concentrations in normal and diabetic man. Metab. Clin. Exp. 1981 Dec; 30(12): 1195-9. PMID: 7031418, ISSN: 0026-0495.

Liljenquist JE, Mueller GL, Cherrington AD, Perry JM, Rabin D. Retardant effect of hyperglycemia on the rise in plasma fatty acids following insulin withdrawal in man. Horm. Metab. Res. 1981 Oct; 13(10): 542-5. PMID: 6117512, DOI: 10.1055/s-2007-1019329, ISSN: 0018-5043.

Diamond MP, Williams PE, Lacy WW, Cherrington AD. Effect of dichloroacetate on gluconeogenesis in vivo in the presence of a fixed gluconeogenic substrate supply to the liver. Metab. Clin. Exp. 1981 Sep; 30(9): 880-5. PMID: 7266378, PII: 0026-0495(81)90066-4, ISSN: 0026-0495.

Deri JJ, Williams PE, Steiner KE, Cherrington AD. Altered ability of the liver to produce glucose following a period of glucagon deficiency. Diabetes. 1981 Jun; 30(6): 490-5. PMID: 6112181, ISSN: 0012-1797.

Cherrington AD, Williams PE, Shulman GI, Lacy WW. Differential time course of glucagon's effect on glycogenolysis and gluconeogenesis in the conscious dog. Diabetes. 1981 Mar; 30(3): 180-7. PMID: 6110598, ISSN: 0012-1797.

Exton JH, Blackmore PF, El-Refai MF, Dehaye JP, Strickland WG, Cherrington AD, Chan TM, Assimacopoulos-Jeannet FD, Chrisman TD. Mechanisms of hormonal regulation of liver metabolism. Adv Cyclic Nucleotide Res. 1981; 14: 491-505. PMID: 6116389, ISSN: 0084-5930.

Diamond MP, Rollings RC, Erlendson L, Williams PE, Lacy WW, Rabin D, Cherrington AD. Dichloroacetate--its in vivo effects on carbohydrate metabolism in the conscious dog. Diabetes. 1980 Sep; 29(9): 702-9. PMID: 7002686, ISSN: 0012-1797.

Chiasson JL, Atkinson RL, Cherrington AD, Keller U, Sinclair-Smith BC, Lacy WW, Liljenquist JE. Effects of insulin at two dose levels on gluconeogenesis from alanine in fasting man. Metab. Clin. Exp. 1980 Sep; 29(9): 810-8. PMID: 6997676, PII: 0026-0495(80)90119-5, ISSN: 0026-0495.

Wilson FA, Antonson DL, Hart BL, Warr TA, Cherrington AD, Liljenquist JE. The effect of somatostatin on the intestinal transport of glucose in vivo and in vitro in the rat. Endocrinology. 1980 May; 106(5): 1562-7. PMID: 6102512, DOI: 10.1210/endo-106-5-1562, ISSN: 0013-7227.

Shulman GI, Williams PE, Liljenquist JE, Lacy WW, Keller U, Cherrington AD. Effect of hyperglycemia independent of changes in insulin or glucagon on lipolysis in the conscious dog. Metab. Clin. Exp. 1980 Apr; 29(4): 317-20. PMID: 6103495, PII: 0026-0495(80)90004-9, ISSN: 0026-0495.

Shulman GI, Lacy WW, Liljenquist JE, Keller U, Williams PE, Cherrington AD. Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog. J. Clin. Invest. 1980 Feb; 65(2): 496-505. PMID: 7356691, PMCID: PMC371388, DOI: 10.1172/JCI109693, ISSN: 0021-9738.

Liljenquist JE, Bloomgarden ZT, Cherrington AD, Perry JM, Rabin D. Possible mechanism by which somatostatin-induced glucagon suppression improves glucose tolerance during insulinopaenia in man. Diabetologia. 1979 Sep; 17(3): 139-43. PMID: 510828, ISSN: 0012-186X.

Cherrington AD, Liljenquist JE, Shulman GI, Williams PE, Lacy WW. Importance of hypoglycemia-induced glucose production during isolated glucagon deficiency. Am. J. Physiol. 1979 Mar; 236(3): E263-71. PMID: 426057, ISSN: 0002-9513.

Chiasson JL, Atkinson RL, Cherrington AD, Keller U, Sinclair-Smith BC, Lacy WW, Liljenquist JE. Effects of fasting on gluconeogenesis from alanine in nondiabetic man. Diabetes. 1979 Jan; 28(1): 56-60. PMID: 759251, ISSN: 0012-1797.

Liljenquist JE, Mueller GL, Cherrington AD, Perry JM, Rabinowitz D. Hyperglycemia per se (insulin and glucagon withdrawn) can inhibit hepatic glucose production in man. J. Clin. Endocrinol. Metab. 1979 Jan; 48(1): 171-5. PMID: 422700, DOI: 10.1210/jcem-48-1-171, ISSN: 0021-972X.

Bloomgarden ZT, Liljenquist JE, Cherrington AD, Rabinowitz D. Persistent stimulatory effect of glucagon on glucose production despite downregulation. J. Clin. Endocrinol. Metab. 1978 Nov; 47(5): 1152-5. PMID: 45472, DOI: 10.1210/jcem-47-5-1152, ISSN: 0021-972X.

Cherrington AD, Lacy WW, Chiasson JL. Effect of glucagon on glucose production during insulin deficiency in the dog. J. Clin. Invest. 1978 Sep; 62(3): 664-77. PMID: 690190, PMCID: PMC371813, DOI: 10.1172/JCI109174, ISSN: 0021-9738.

Keller U, Cherrington AD, Liljenquist JE. Ketone body turnover and net hepatic ketone production in fasted and diabetic dogs. Am. J. Physiol. 1978 Aug; 235(2): E238-47. PMID: 686170, ISSN: 0002-9513.

Cherrington AD, Williams PE, Harris MS. Relationship between the plasma glucose level and glucose uptake in the conscious dog. Metab. Clin. Exp. 1978 Jul; 27(7): 787-91. PMID: 661564, PII: 0026-0495(78)90213-5, ISSN: 0026-0495.

Cherrington AD, Chiasson JL, Liljenquist JE, Lacy WW, Park CR. Control of hepatic glucose output by glucagon and insulin in the intact dog. Biochem. Soc. Symp. 1978; (43): 31-45. PMID: 373768, ISSN: 0067-8694.

Exton JH, Assimacopoulos-Jeannet FD, Blackmore PF, Cherrington AD, Chan TM. Mechanisms of catecholamine actions on liver carbohydrate metabolism. Adv Cyclic Nucleotide Res. 1978; 9: 441-52. PMID: 208389, ISSN: 0084-5930.

Shulman, GI, Liljenquist, JE, Williams, PE, Lacy, WW, Cherrington, AD. Glucose disposal during insulinopenia in somatostatin-treated dogs: The roles of glucose and glucagon. J Clin Invest. 1978; 62: 487-91.

Exton JH, Assimacopoulos-Jeannet FD, Blackmore PF, Cherrington AD, Chan TM. Mechanisms of catecholamine action on liver carbohydrate metabolism [editorial]. Advances in Cyclic Nucleotide Research. 1978; WJ George and LJ Ignarro (Eds). Raven Press, N: 441-752.

Pilkis SJ, Claus TH, Riou J-P, Cherrington AD, Chiasson JL, Liljenquist JE, Lacy WW, Park CR. Control of hepatic gluconeogenesis and glucose output by glucagon and insulin. In: Regulatory Mechanisms of Carbohydrate Metabolism [editorial]. Regulatory Mechanisms of Carbohydrate Metabolism. 1978; 42((V Esmann (Ed). Federation of the European Biochem Society, 11th Meeting. Pergamon Press, Oxford)): 13-29.

Exton JH, Cherrington AD, Hutson NJ, Assimacopoulos-Jeannet FD, Blackmore PF. Cyclic AMP-mediated and non-cAMP mediated hormonal control of liver glycogenolysis [editorial]. Proceedings of the 11th FEBS Meetings: Regulatory Mechanisms of Carbohydrate Metabolism. 1978; 42((V Esmann (Ed). Pergamon Press)): 317-26.

Cherrington AD, Chiasson JL, Liljenquist JE, Lacy WW, Park CR. Control of hepatic glucose output by glucagon and insulin in the intact dog [editorial]. Biochemical Society Symposia, Substrate Mobilization and Energy Provision in Man. 1978; 43((PB Garland and CN Hales (Eds). London: The Biochemical Society)): 31-41.

Keller U, Chiasson JL, Liljenquist JE, Cherrington AD, Jennings AS, Crofford OS. The roles of insulin, glucagon, and free fatty acids in the regulation of ketogenesis in dogs. Diabetes. 1977 Nov; 26(11): 1040-51. PMID: 913893, ISSN: 0012-1797.

Jennings AS, Cherrington AD, Liljenquist JE, Keller U, Lacy WW, Chiasson JL. The roles of insulin and glucagon in the regulation of gluconeogenesis in the postabsorptive dog. Diabetes. 1977 Sep; 26(9): 847-56. PMID: 892238, ISSN: 0012-1797.

Cherrington AD, Hundley RF, Dolgin S, Exton JH. Studies of the role of beta-adrenergic receptors in the activation of phosphorylase in rat hepatocytes by catecholamines. J Cyclic Nucleotide Res. 1977 Aug; 3(4): 263-73. PMID: 199628, ISSN: 0095-1544.

Cherrington AD, Caldwell MD, Dietz MR, Exton JH, Crofford OB. The effect of somatostatin on glucose uptake and production by rat tissues in vitro. Diabetes. 1977 Aug; 26(8): 740-8. PMID: 195856, ISSN: 0012-1797.

Liljenquist JE, Mueller GL, Cherrington AD, Keller U, Chiasson J-L, Perry JM, Lacy WW, Rabinowitz D. Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man. J. Clin. Invest. 1977 Feb; 59(2): 369-74. PMID: 833282, PMCID: PMC333368, DOI: 10.1172/JCI108649, ISSN: 0021-9738.

Chiasson JL, Liljenquist JE, Lacy WW, Jennings AS, Cherrington AD. Gluconeogenesis: methodological approaches in vivo. Fed. Proc. 1977 Feb; 36(2): 229-35. PMID: 320052, ISSN: 0014-9446.

Exton JH, Cherrington AD, Hutson NJ, Assimacopoulos-Jeannet FD. Reexamination of the second messenger hypothesis of glucagon and catecholamine action in the liver [editorial]. Glucagon, Its Role in Physiology and Clinical Medicine. 1977; P Foa, J Baiai and NL Foa (Eds). Springer Verlag, NY: 321-47.

Cherrington AD, Chiasson JL, Liljenquist JE, Jennings AS, Keller U, Lacy WW. The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog. J. Clin. Invest. 1976 Dec; 58(6): 1407-18. PMID: 993351, PMCID: PMC333312, DOI: 10.1172/JCI108596, ISSN: 0021-9738.

Liljenquist JE, Chiassan JL, Cherrington AD, Keller U, Jennings AS, Bomboy JD, Lacy WW. An important role for glucagon in the regulation of glucose production in vivo. Metab. Clin. Exp. 1976 Nov; 25(11 Suppl 1): 1371-3. PMID: 979637, ISSN: 0026-0495.

Cherrington AD, Exton JH. Studies on the role of cAMP-dependent protein kinase in the actions of glucagon and catecholamines on liver glycogen metabolism. Metab. Clin. Exp. 1976 Nov; 25(11 Suppl 1): 1351-4. PMID: 185493, ISSN: 0026-0495.

Cherrington AD, Assimacopoulos FD, Harper SC, Corbin JD, Park CR, Exton JH. Studies on the alpha-andrenergic activation of hepatic glucose output. II. Investigation of the roles of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in the actions of phenylephrine in isolated hepatocytes. J. Biol. Chem. 1976 Sep 9/10/1976; 251(17): 5209-18. PMID: 8457, ISSN: 0021-9258.

Rabinowitz D, Liljenquist JE, Mueller GL, Cherrington AD, Keller U, Chiasson JL, Perry JM, Lacy WW. Somatostatin: a powerful tool for in situ studies on splanchnic metabolism [editorial]. The Proceedings of the Ninth Congress of the International Diabetes Federation (New Delhi). 1976; Excerpta Medica: 51-5.

Exton JH, Cherrington AD. Reexamination of the role of cyclic AMP in the actions of glucagon and epinephrine [editorial]. Eukaryotic Cell Function and Growth. Regulation by Intracellular Cyclic Nucleotides. 1976; JE Dumont, BL Brown and NJ Marshall (Eds). Plenum Press, NY: 467-96.

Cherrington AD, Kawamori R, Pek S, Vranic M. Arginine infusion in dogs. Model for the roles of insulin and glucagon in regulating glucose turnover and free fatty acid levels. Diabetes. 1974 Oct; 23(10): 805-15. PMID: 4422477, ISSN: 0012-1797.

Cherrington AD, Vranic M. Effect of interaction between insulin and glucagon on glucose turnover and FFA concentration in normal and depancreatized dogs. Metab. Clin. Exp. 1974 Aug; 23(8): 729-44. PMID: 4851653, PII: 0026-0495(74)90005-5, ISSN: 0026-0495.

Park, CR, Lewis, SB, Claus, T, Pilkis, S, Cherrington, A, Exton, JH. Effect of glucagon, catecholamines and insulin on hepatic levels of cyclic adenylate: A summary [editorial]. Regulation of Hepatic Metabolism. 1974; F Lunquist and N Tygstrup (Eds). Munksgaard, Copenhagen: 677-82.

Cherrington AD, Vranic M. Effect of arginine on glucose turnover and plasma free fatty acids in normal dogs. Diabetes. 1973 Jul; 22(7): 537-43. PMID: 4578218, ISSN: 0012-1797.

Vranic M, Radziuk J, Cherrington AD. The role of glucagon and insulin in the glucoregulatory system; as assessed by tracer methods [editorial]. Regulation and Control in Physiological Systems. 1973; AS Iberall and AC Guyton (Eds). Pittsburg: 487-90.

Vranic, M, Cherrington, AD. The regulation of glucose turnover (mobilization and supply) and FFA concentration by insulin-glucagon interactions in dogs [editorial]. Diabetes: Proceedings of the Eighth Congress of the International Diabetes Federation, Brussels. 1973; J Malaisse and J Pirart (Eds), Excerpta Medica, Amsterdam: 256-70.

Cherrington A, Vranic M, Fono P, Kovacevic N. Effect of glucagon on glucose turnover and plasma free fatty acids in depancreatized dogs maintained on matched insulin infusions. Can. J. Physiol. Pharmacol. 1972 Oct; 50(10): 946-54. PMID: 4637182, ISSN: 0008-4212.

Cherrington A, Vranic M. Role of glucagon and insulin in control of glucose turnover. Metab. Clin. Exp. 1971 Jun; 20(6): 625-8. PMID: 5578975, PII: 0026-0495(71)90010-2, ISSN: 0026-0495.

Cherrington, AD, Paim, U, Page, OT. In vitro degradation of DDT by intestinal contents of Atlantic salmon (Salmo salar). J Fish Res Bd Can. 1969; 26: 47-54.

Van Petten GR, Hirsch GH, Cherrington AD. Drug-metabolizing activity of the human placenta. Can. J. Biochem. 1968 Sep; 46(9): 1057-61. PMID: 5687633, ISSN: 0008-4018.