Pierre P. Massion, M.D.


Faculty Appointments
Professor of Medicine Professor of Cancer BiologyCornelius Vanderbilt Chair in Medicine
M.D., Medicine, Universiti Catholique de Louvain, Louvain, BelgiumB.S., Biology, Universiti Catholique de Louvain, Louvain, Belgium
Office Address
640 PRB
TN 6838
Research Description
1. Role of chromosome 3q in lung cancer. Selection of candidate genes driving a genomic amplicon on Chromosome 3q. Focus on functional genomics for candidate driver genes on chromosome 3q such as p63 and PIK3CA. RO1 funded.

2. Proteomic approach to preinvasive lung cancer. Protein profiling of preinvasive lesions in bronchial biopsy and invasive lung cancer by MALDI MS; Identification of discriminatory proteins by LC-MSMS proteomics; Image analysis. funded by RO1 and SPORE in lung cancer.

3. Lung cancer biomarker discovery and validation. Identification of discriminatory proteins between lung cancer and controls after multidimensional mass spectrometry analysis of biological specimen and Phage-display recombinant antibody library (serum, plasma or pleural fluid). Funded by Vanderbilt SPORE in lung cancer, VA Merit review grant, ASCO research award and EDRN Clinical Validation Center (U01).

4. Inflammation and cancer. We are working on 3 proteins. PPAR delta in lung tumorigenesis (Pedchenko, 2008), Role of serum amyloid A in regulating apoptosis in lung cancer cells, and pIgR as a potential tumor suppressor gene in lung cancer (Polosukhin, 2007). Work supported by Damon Runyon Foundation and a Vanderbilt Discovery Grant.
Research Keywords
The laboratory of Dr. Massion emphasis is on lung tumorigenesis and on using genomic and proteomic approaches to identify molecular markers of lung neoplasia and to test those in multidisciplinary early detection strategies.
Clinical Research Keywords
Lung cancer, biomarkers, early detection, tobacco, chemoprevention
Hassanein M, Qian J, Hoeksema MD, Wang J, Jacobovitz M, Ji X, Harris FT, Harris BK, Boyd KL, Chen H, Eisenberg R, Massion PP. Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer. Int. J. Cancer [print-electronic]. 2015 Oct 10/1/2015; 137(7): 1587-97. PMID: 25821004, PMCID: PMC4640891, DOI: 10.1002/ijc.29535, ISSN: 1097-0215.

Hassanein M, Hight MR, Buck JR, Tantawy MN, Nickels ML, Hoeksema MD, Harris BK, Boyd K, Massion PP, Manning HC. Preclinical Evaluation of 4-[(18)F]Fluoroglutamine PET to Assess ASCT2 Expression in Lung Cancer. Mol Imaging Biol [print-electronic]. 2015 May 5/14/2015; PMID: 25971659, PMCID: PMC4644503, DOI: 10.1007/s11307-015-0862-4, ISSN: 1860-2002.

Vachani A, Pass HI, Rom WN, Midthun DE, Edell ES, Laviolette M, Li XJ, Fong PY, Hunsucker SW, Hayward C, Mazzone PJ, Madtes DK, Miller YE, Walker MG, Shi J, Kearney P, Fang KC, Massion PP. Validation of a multiprotein plasma classifier to identify benign lung nodules. J Thorac Oncol. 2015 Apr; 10(4): 629-37. PMID: 25590604, PMCID: PMC4382127, DOI: 10.1097/JTO.0000000000000447, ISSN: 1556-1380.

Qian J, Hassanein M, Hoeksema MD, Harris BK, Zou Y, Chen H, Lu P, Eisenberg R, Wang J, Espinosa A, Ji X, Harris FT, Rahman SM, Massion PP. The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2015 Mar 3/17/2015; 112(11): 3469-74. PMID: 25733852, PMCID: PMC4371932, PII: 1421975112, DOI: 10.1073/pnas.1421975112, ISSN: 1091-6490.

Kropski JA, Pritchett JM, Zoz DF, Crossno PF, Markin C, Garnett ET, Degryse AL, Mitchell DB, Polosukhin VV, Rickman OB, Choi L, Cheng DS, McConaha ME, Jones BR, Gleaves LA, McMahon FB, Worrell JA, Solus JF, Ware LB, Lee JW, Massion PP, Zaynagetdinov R, White ES, Kurtis JD, Johnson JE, Groshong SD, Lancaster LH, Young LR, Steele MP, Phillips Iii JA, Cogan JD, Loyd JE, Lawson WE, Blackwell TS. Extensive phenotyping of individuals at risk for familial interstitial pneumonia reveals clues to the pathogenesis of interstitial lung disease. Am. J. Respir. Crit. Care Med. 2015 Feb 2/15/2015; 191(4): 417-26. PMID: 25389906, PMCID: PMC4351594, DOI: 10.1164/rccm.201406-1162OC, ISSN: 1535-4970.

Aldrich MC, Munro HM, Mumma M, Grogan EL, Massion PP, Blackwell TS, Blot WJ. Chronic obstructive pulmonary disease and subsequent overall and lung cancer mortality in low-income adults. PLoS ONE. 2015; 10(3): e0121805. PMID: 25811837, PMCID: PMC4374870, PII: PONE-D-14-50985, DOI: 10.1371/journal.pone.0121805, ISSN: 1932-6203.

Wood DE, Kazerooni E, Baum SL, Dransfield MT, Eapen GA, Ettinger DS, Hou L, Jackman DM, Klippenstein D, Kumar R, Lackner RP, Leard LE, Leung AN, Makani SS, Massion PP, Meyers BF, Otterson GA, Peairs K, Pipavath S, Pratt-Pozo C, Reddy C, Reid ME, Rotter AJ, Sachs PB, Schabath MB, Sequist LV, Tong BC, Travis WD, Yang SC, Gregory KM, Hughes M, . Lung cancer screening, version 1.2015: featured updates to the NCCN guidelines. J Natl Compr Canc Netw. 2015 Jan; 13(1): 23-34; quiz 34. PMID: 25583767, PII: 13/1/23.

Massion PP, Walker RC. Indeterminate pulmonary nodules: risk for having or for developing lung cancer?. Cancer Prev Res (Phila) [print-electronic]. 2014 Dec; 7(12): 1173-8. PMID: 25348855, PII: 1940-6207.CAPR-14-0364, DOI: 10.1158/1940-6207.CAPR-14-0364, ISSN: 1940-6215.

Deppen SA, Blume JD, Aldrich MC, Fletcher SA, Massion PP, Walker RC, Chen HC, Speroff T, Degesys CA, Pinkerman R, Lambright ES, Nesbitt JC, Putnam JB, Grogan EL. Predicting lung cancer prior to surgical resection in patients with lung nodules. J Thorac Oncol. 2014 Oct; 9(10): 1477-84. PMID: 25170644, PMCID: PMC4272613, DOI: 10.1097/JTO.0000000000000287, ISSN: 1556-1380.

Deppen SA, Blume JD, Kensinger CD, Morgan AM, Aldrich MC, Massion PP, Walker RC, McPheeters ML, Putnam JB, Grogan EL. Accuracy of FDG-PET to diagnose lung cancer in areas with infectious lung disease: a meta-analysis. JAMA. 2014 Sep 9/24/2014; 312(12): 1227-36. PMID: 25247519, PMCID: PMC4315183, PII: 1906615, DOI: 10.1001/jama.2014.11488, ISSN: 1538-3598.

Braun NA, Celada LJ, Herazo-Maya JD, Abraham S, Shaginurova G, Sevin CM, Grutters J, Culver DA, Dworski R, Sheller J, Massion PP, Polosukhin VV, Johnson JE, Kaminski N, Wilkes DS, Oswald-Richter KA, Drake WP. Blockade of the programmed death-1 pathway restores sarcoidosis CD4(+) T-cell proliferative capacity. Am. J. Respir. Crit. Care Med. 2014 Sep 9/1/2014; 190(5): 560-71. PMID: 25073001, PMCID: PMC4214083, DOI: 10.1164/rccm.201401-0188OC, ISSN: 1535-4970.

Olmsted IR, Hassanein M, Kussrow A, Hoeksema M, Li M, Massion PP, Bornhop DJ. Toward rapid, high-sensitivity, volume-constrained biomarker quantification and validation using backscattering interferometry. Anal. Chem [print-electronic]. 2014 Aug 8/5/2014; 86(15): 7566-74. PMID: 24954171, PMCID: PMC4215853, DOI: 10.1021/ac501355q, ISSN: 1520-6882.

Harris FT, Rahman SM, Hassanein M, Qian J, Hoeksema MD, Chen H, Eisenberg R, Chaurand P, Caprioli RM, Shiota M, Massion PP. Acyl-coenzyme A-binding protein regulates Beta-oxidation required for growth and survival of non-small cell lung cancer. Cancer Prev Res (Phila) [print-electronic]. 2014 Jul; 7(7): 748-57. PMID: 24819876, PMCID: PMC4090029, PII: 1940-6207.CAPR-14-0057, DOI: 10.1158/1940-6207.CAPR-14-0057, ISSN: 1940-6215.

Deppen SA, Grogan EL, Aldrich MC, Massion PP. Lung cancer screening and smoking cessation: a teachable moment? [editorial]. J. Natl. Cancer Inst [electronic-print]. 2014 Jun; 106(6): dju122. PMID: 24872542, PII: dju122, DOI: 10.1093/jnci/dju122, ISSN: 1460-2105.

Massion PP. Biomarkers to the rescue in a lung nodule epidemic [editorial]. J. Clin. Oncol [print-electronic]. 2014 Mar 3/10/2014; 32(8): 725-6. PMID: 24516023, PII: JCO.2013.54.0047, DOI: 10.1200/JCO.2013.54.0047, ISSN: 1527-7755.

Ocak S, Friedman DB, Chen H, Ausborn JA, Hassanein M, Detry B, Weynand B, Aboubakar F, Pilette C, Sibille Y, Massion PP. Discovery of new membrane-associated proteins overexpressed in small-cell lung cancer. J Thorac Oncol. 2014 Mar; 9(3): 324-36. PMID: 24518087, PMCID: PMC4028683, PII: 01243894-201403000-00009, DOI: 10.1097/JTO.0000000000000090, ISSN: 1556-1380.

Li XJ, Hayward C, Fong PY, Dominguez M, Hunsucker SW, Lee LW, McLean M, Law S, Butler H, Schirm M, Gingras O, Lamontagne J, Allard R, Chelsky D, Price ND, Lam S, Massion PP, Pass H, Rom WN, Vachani A, Fang KC, Hood L, Kearney P. A blood-based proteomic classifier for the molecular characterization of pulmonary nodules. Sci Transl Med. 2013 Oct 10/16/2013; 5(207): 207ra142. PMID: 24132637, PMCID: PMC4114963, PII: 5/207/207ra142, DOI: 10.1126/scitranslmed.3007013, ISSN: 1946-6242.

Wang J, Qian J, Hoeksema MD, Zou Y, Espinosa AV, Rahman SM, Zhang B, Massion PP. Integrative genomics analysis identifies candidate drivers at 3q26-29 amplicon in squamous cell carcinoma of the lung. Clin. Cancer Res [print-electronic]. 2013 Oct 10/15/2013; 19(20): 5580-90. PMID: 23908357, PMCID: PMC3807802, PII: 1078-0432.CCR-13-0594, DOI: 10.1158/1078-0432.CCR-13-0594, ISSN: 1078-0432.

Ajona D, Pajares MJ, Corrales L, Perez-Gracia JL, Agorreta J, Lozano MD, Torre W, Massion PP, de-Torres JP, Jantus-Lewintre E, Camps C, Zulueta JJ, Montuenga LM, Pio R. Investigation of complement activation product c4d as a diagnostic and prognostic biomarker for lung cancer. J. Natl. Cancer Inst [print-electronic]. 2013 Sep 9/18/2013; 105(18): 1385-93. PMID: 23940286, PMCID: PMC3776260, PII: djt205, DOI: 10.1093/jnci/djt205, ISSN: 1460-2105.

Aberle DR, DeMello S, Berg CD, Black WC, Brewer B, Church TR, Clingan KL, Duan F, Fagerstrom RM, Gareen IF, Gatsonis CA, Gierada DS, Jain A, Jones GC, Mahon I, Marcus PM, Rathmell JM, Sicks J, . Results of the two incidence screenings in the National Lung Screening Trial. N. Engl. J. Med. 2013 Sep 9/5/2013; 369(10): 920-31. PMID: 24004119, PMCID: PMC4307922, DOI: 10.1056/NEJMoa1208962, ISSN: 1533-4406.

Ardestani S, Li B, Deskins DL, Wu H, Massion PP, Young PP. Membrane versus soluble isoforms of TNF-a exert opposing effects on tumor growth and survival of tumor-associated myeloid cells. Cancer Res [print-electronic]. 2013 Jul 7/1/2013; 73(13): 3938-50. PMID: 23704210, PMCID: PMC3702680, PII: 0008-5472.CAN-13-0002, DOI: 10.1158/0008-5472.CAN-13-0002, ISSN: 1538-7445.

Giacalone NJ, Den RB, Eisenberg R, Chen H, Olson SJ, Massion PP, Carbone DP, Lu B. ALDH7A1 expression is associated with recurrence in patients with surgically resected non-small-cell lung carcinoma. Future Oncol. 2013 May; 9(5): 737-45. PMID: 23647301, DOI: 10.2217/fon.13.19, ISSN: 1744-8301.

Hassanein M, Hoeksema MD, Shiota M, Qian J, Harris BK, Chen H, Clark JE, Alborn WE, Eisenberg R, Massion PP. SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival. Clin. Cancer Res [print-electronic]. 2013 Feb 2/1/2013; 19(3): 560-70. PMID: 23213057, PMCID: PMC3697078, PII: 1078-0432.CCR-12-2334, DOI: 10.1158/1078-0432.CCR-12-2334, ISSN: 1078-0432.

Pedchenko T, Mernaugh R, Parekh D, Li M, Massion PP. Early detection of NSCLC with scFv selected against IgM autoantibody. PLoS ONE [electronic-print]. 2013; 8(4): e60934. PMID: 23585862, PMCID: PMC3621672, PII: PONE-D-12-34071, DOI: 10.1371/journal.pone.0060934, ISSN: 1932-6203.

Udyavar AR, Hoeksema MD, Clark JE, Zou Y, Tang Z, Li Z, Li M, Chen H, Statnikov A, Shyr Y, Liebler DC, Field J, Eisenberg R, Estrada L, Massion PP, Quaranta V. Co-expression network analysis identifies Spleen Tyrosine Kinase (SYK) as a candidate oncogenic driver in a subset of small-cell lung cancer. BMC Syst Biol [print-electronic]. 2013; 7 Suppl 5: S1. PMID: 24564859, PMCID: PMC4029366, PII: 1752-0509-7-S5-S1, DOI: 10.1186/1752-0509-7-S5-S1, ISSN: 1752-0509.

Pecot CV, Rupaimoole R, Yang D, Akbani R, Ivan C, Lu C, Wu S, Han HD, Shah MY, Rodriguez-Aguayo C, Bottsford-Miller J, Liu Y, Kim SB, Unruh A, Gonzalez-Villasana V, Huang L, Zand B, Moreno-Smith M, Mangala LS, Taylor M, Dalton HJ, Sehgal V, Wen Y, Kang Y, Baggerly KA, Lee JS, Ram PT, Ravoori MK, Kundra V, Zhang X, Ali-Fehmi R, Gonzalez-Angulo AM, Massion PP, Calin GA, Lopez-Berestein G, Zhang W, Sood AK. Tumour angiogenesis regulation by the miR-200 family. Nat Commun. 2013; 4: 2427. PMID: 24018975, PMCID: PMC3904438, PII: ncomms3427, DOI: 10.1038/ncomms3427, ISSN: 2041-1723.

Kikuchi T, Hassanein M, Amann JM, Liu Q, Slebos RJ, Rahman SM, Kaufman JM, Zhang X, Hoeksema MD, Harris BK, Li M, Shyr Y, Gonzalez AL, Zimmerman LJ, Liebler DC, Massion PP, Carbone DP. In-depth proteomic analysis of nonsmall cell lung cancer to discover molecular targets and candidate biomarkers. Mol. Cell Proteomics [print-electronic]. 2012 Oct; 11(10): 916-32. PMID: 22761400, PMCID: PMC3494148, PII: M111.015370, DOI: 10.1074/mcp.M111.015370, ISSN: 1535-9484.

Hassanein M, Callison JC, Callaway-Lane C, Aldrich MC, Grogan EL, Massion PP. The state of molecular biomarkers for the early detection of lung cancer. Cancer Prev Res (Phila) [print-electronic]. 2012 Aug; 5(8): 992-1006. PMID: 22689914, PMCID: PMC3723112, PII: 1940-6207.CAPR-11-0441, DOI: 10.1158/1940-6207.CAPR-11-0441, ISSN: 1940-6215.

Pecot CV, Li M, Zhang XJ, Rajanbabu R, Calitri C, Bungum A, Jett JR, Putnam JB, Callaway-Lane C, Deppen S, Grogan EL, Carbone DP, Worrell JA, Moons KG, Shyr Y, Massion PP. Added value of a serum proteomic signature in the diagnostic evaluation of lung nodules. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2012 May; 21(5): 786-92. PMID: 22374995, PMCID: PMC3660018, PII: 1055-9965.EPI-11-0932, DOI: 10.1158/1055-9965.EPI-11-0932, ISSN: 1538-7755.

Ocak S, Pedchenko TV, Chen H, Harris FT, Qian J, Polosukhin V, Pilette C, Sibille Y, Gonzalez AL, Massion PP. Loss of polymeric immunoglobulin receptor expression is associated with lung tumourigenesis. Eur. Respir. J [print-electronic]. 2012 May; 39(5): 1171-80. PMID: 21965228, PMCID: PMC3717253, PII: 09031936.00184410, DOI: 10.1183/09031936.00184410, ISSN: 1399-3003.

Ocak S, Chen H, Callison C, Gonzalez AL, Massion PP. Expression of focal adhesion kinase in small-cell lung carcinoma. Cancer [print-electronic]. 2012 Mar 3/1/2012; 118(5): 1293-301. PMID: 21800286, PMCID: PMC3673887, DOI: 10.1002/cncr.26382, ISSN: 1097-0142.

Grogan EL, Weinstein JJ, Deppen SA, Putnam JB, Nesbitt JC, Lambright ES, Walker RC, Dittus RS, Massion PP. Thoracic operations for pulmonary nodules are frequently not futile in patients with benign disease. J Thorac Oncol. 2011 Oct; 6(10): 1720-5. PMID: 21760552, PMCID: PMC3712870, DOI: 10.1097/JTO.0b013e318226b48a, ISSN: 1556-1380.

Deppen S, Putnam JB, Andrade G, Speroff T, Nesbitt JC, Lambright ES, Massion PP, Walker R, Grogan EL. Accuracy of FDG-PET to diagnose lung cancer in a region of endemic granulomatous disease. Ann. Thorac. Surg [print-electronic]. 2011 Aug; 92(2): 428-32; discussion 433. PMID: 21592456, PMCID: PMC3186439, PII: S0003-4975(11)00478-4, DOI: 10.1016/j.athoracsur.2011.02.052, ISSN: 1552-6259.

Polosukhin VV, Cates JM, Lawson WE, Zaynagetdinov R, Milstone AP, Massion PP, Ocak S, Ware LB, Lee JW, Bowler RP, Kononov AV, Randell SH, Blackwell TS. Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med [print-electronic]. 2011 Aug 8/1/2011; 184(3): 317-27. PMID: 21512171, PMCID: PMC3265275, PII: 201010-1629OC, DOI: 10.1164/rccm.201010-1629OC, ISSN: 1535-4970.

Zhang H, Liu Q, Zimmerman LJ, Ham AJ, Slebos RJ, Rahman J, Kikuchi T, Massion PP, Carbone DP, Billheimer D, Liebler DC. Methods for peptide and protein quantitation by liquid chromatography-multiple reaction monitoring mass spectrometry. Mol. Cell Proteomics [print-electronic]. 2011 Jun; 10(6): M110.006593. PMID: 21357624, PMCID: PMC3108838, PII: M110.006593, DOI: 10.1074/mcp.M110.006593, ISSN: 1535-9484.

Polosukhin VV, Cates JM, Lawson WE, Milstone AP, Matafonov AG, Massion PP, Lee JW, Randell SH, Blackwell TS. Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium. J. Pathol. 2011 Jun; 224(2): 203-11. PMID: 21557221, DOI: 10.1002/path.2863, ISSN: 1096-9896.

Kashikar ND, Zhang W, Massion PP, Gonzalez AL, Datta PK. Role of STRAP in regulating GSK3ß function and Notch3 stabilization. Cell Cycle [print-electronic]. 2011 May 5/15/2011; 10(10): 1639-54. PMID: 21502811, PMCID: PMC3127163, PII: 15630, ISSN: 1551-4005.

Hassanein M, Rahman JS, Chaurand P, Massion PP. Advances in proteomic strategies toward the early detection of lung cancer. Proc Am Thorac Soc. 2011 May; 8(2): 183-8. PMID: 21543799, PMCID: PMC3131837, PII: 8/2/183, DOI: 10.1513/pats.201012-069MS, ISSN: 1943-5665.

Rahman SM, Gonzalez AL, Li M, Seeley EH, Zimmerman LJ, Zhang XJ, Manier ML, Olson SJ, Shah RN, Miller AN, Putnam JB, Miller YE, Franklin WA, Blot WJ, Carbone DP, Shyr Y, Caprioli RM, Massion PP. Lung cancer diagnosis from proteomic analysis of preinvasive lesions. Cancer Res [print-electronic]. 2011 Apr 4/15/2011; 71(8): 3009-17. PMID: 21487035, PMCID: PMC3110721, PII: 0008-5472.CAN-10-2510, DOI: 10.1158/0008-5472.CAN-10-2510, ISSN: 1538-7445.

Su Z, Dias-Santagata D, Duke M, Hutchinson K, Lin YL, Borger DR, Chung CH, Massion PP, Vnencak-Jones CL, Iafrate AJ, Pao W. A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer. J Mol Diagn [print-electronic]. 2011 Jan; 13(1): 74-84. PMID: 21227397, PMCID: PMC3070558, PII: S1525-1578(10)00024-3, DOI: 10.1016/j.jmoldx.2010.11.010, ISSN: 1943-7811.

Isbell JM, Deppen S, Putnam JB, Nesbitt JC, Lambright ES, Dawes A, Massion PP, Speroff T, Jones DR, Grogan EL. Existing general population models inaccurately predict lung cancer risk in patients referred for surgical evaluation. Ann. Thorac. Surg. 2011 Jan; 91(1): 227-33; discussion 233. PMID: 21172518, PMCID: PMC3748597, PII: S0003-4975(10)01933-8, DOI: 10.1016/j.athoracsur.2010.08.054, ISSN: 1552-6259.

Ocak S, Yamashita H, Udyavar AR, Miller AN, Gonzalez AL, Zou Y, Jiang A, Yi Y, Shyr Y, Estrada L, Quaranta V, Massion PP. DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway. Oncogene [print-electronic]. 2010 Dec 12/2/2010; 29(48): 6331-42. PMID: 20802517, PMCID: PMC4637980, PII: onc2010362, DOI: 10.1038/onc.2010.362, ISSN: 1476-5594.

Grogan EL, Deppen S, Pecot CV, Putnam JB, Nesbitt JC, Shyr Y, Rajanbabu R, Ory B, Lambright ES, Massion PP. Diagnostic characteristics of a serum biomarker in patients with positron emission tomography scans. Ann. Thorac. Surg. 2010 Jun; 89(6): 1724-8; discussion 1728. PMID: 20494018, PMCID: PMC3026702, PII: S0003-4975(10)00602-8, DOI: 10.1016/j.athoracsur.2010.03.008, ISSN: 1552-6259.

Ocak S, Sos ML, Thomas RK, Massion PP. High-throughput molecular analysis in lung cancer: insights into biology and potential clinical applications. Eur. Respir. J. 2009 Aug; 34(2): 489-506. PMID: 19648524, PMCID: PMC4648268, PII: 34/2/489, DOI: 10.1183/09031936.00042409, ISSN: 1399-3003.

Ocak S, Chaurand P, Massion PP. Mass spectrometry-based proteomic profiling of lung cancer. Proc Am Thorac Soc. 2009 Apr 4/15/2009; 6(2): 159-70. PMID: 19349484, PMCID: PMC2674226, PII: 6/2/159, DOI: 10.1513/pats.200809-108LC, ISSN: 1546-3222.

Massion PP, Zou Y, Uner H, Kiatsimkul P, Wolf HJ, Baron AE, Byers T, Jonsson S, Lam S, Hirsch FR, Miller YE, Franklin WA, Varella-Garcia M. Recurrent genomic gains in preinvasive lesions as a biomarker of risk for lung cancer. PLoS ONE. 2009; 4(6): e5611. PMID: 19547694, PMCID: PMC2699220, DOI: 10.1371/journal.pone.0005611, ISSN: 1932-6203.

Wehbe FH, Brown SH, Massion PP, Gadd CS, Masys DR, Aliferis CF. A novel information retrieval model for high-throughput molecular medicine modalities. Cancer Inform. 2009; 8: 1-17. PMID: 19458790, PMCID: PMC2664697, ISSN: 1176-9351.

Qian J, Zou Y, Rahman JS, Lu B, Massion PP. Synergy between phosphatidylinositol 3-kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung. Mol. Cancer Ther. 2009 Jan; 8(1): 101-9. PMID: 19139118, PMCID: PMC3110728, PII: 8/1/101, DOI: 10.1158/1535-7163.MCT-08-0973, ISSN: 1535-7163.

DeBusk LM, Massion PP, Lin PC. IkappaB kinase-alpha regulates endothelial cell motility and tumor angiogenesis. Cancer Res. 2008 Dec 12/15/2008; 68(24): 10223-8. PMID: 19074890, PII: 68/24/10223, DOI: 10.1158/0008-5472.CAN-08-1833, ISSN: 1538-7445.

Pedchenko TV, Gonzalez AL, Wang D, DuBois RN, Massion PP. Peroxisome proliferator-activated receptor beta/delta expression and activation in lung cancer. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2008 Dec; 39(6): 689-96. PMID: 18566335, PMCID: PMC3159083, PII: 2007-0426OC, DOI: 10.1165/rcmb.2007-0426OC, ISSN: 1535-4989.

Massion PP, Zou Y, Chen H, Jiang A, Coulson P, Amos CI, Wu X, Wistuba I, Wei Q, Shyr Y, Spitz MR. Smoking-related genomic signatures in non-small cell lung cancer. Am. J. Respir. Crit. Care Med [print-electronic]. 2008 Dec 12/1/2008; 178(11): 1164-72. PMID: 18776155, PMCID: PMC2720147, PII: 200801-142OC, DOI: 10.1164/rccm.200801-142OC, ISSN: 1535-4970.

Xu BJ, Gonzalez AL, Kikuchi T, Yanagisawa K, Massion PP, Wu H, Mason SE, Olson SJ, Shyr Y, Carbone DP, Caprioli RM. MALDI-MS derived prognostic protein markers for resected non-small cell lung cancer. Proteomics Clin Appl [print-electronic]. 2008 Oct; 2(10-11): 1508-17. PMID: 21136798, PMCID: PMC3728564, DOI: 10.1002/prca.200800094, ISSN: 1862-8346.

Groseclose MR, Massion PP, Chaurand P, Caprioli RM. High-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue microarrays using MALDI imaging mass spectrometry. Proteomics. 2008 Sep; 8(18): 3715-24. PMID: 18712763, PMCID: PMC2927989, DOI: 10.1002/pmic.200800495, ISSN: 1615-9861.

Qian J, Massion PP. Role of chromosome 3q amplification in lung cancer. J Thorac Oncol. 2008 Mar; 3(3): 212-5. PMID: 18317062, PII: 01243894-200803000-00004, DOI: 10.1097/JTO.0b013e3181663544, ISSN: 1556-1380.

Yildiz PB, Shyr Y, Rahman JS, Wardwell NR, Zimmerman LJ, Shakhtour B, Gray WH, Chen S, Li M, Roder H, Liebler DC, Bigbee WL, Siegfried JM, Weissfeld JL, Gonzalez AL, Ninan M, Johnson DH, Carbone DP, Caprioli RM, Massion PP. Diagnostic accuracy of MALDI mass spectrometric analysis of unfractionated serum in lung cancer. J Thorac Oncol. 2007 Oct; 2(10): 893-901. PMID: 17909350, PMCID: PMC4220686, PII: 01243894-200710000-00004, DOI: 10.1097/JTO.0b013e31814b8be7, ISSN: 1556-1380.

Polosukhin VV, Lawson WE, Milstone AP, Egunova SM, Kulipanov AG, Tchuvakin SG, Massion PP, Blackwell TS. Association of progressive structural changes in the bronchial epithelium with subepithelial fibrous remodeling: a potential role for hypoxia. Virchows Arch [print-electronic]. 2007 Oct; 451(4): 793-803. PMID: 17674038, DOI: 10.1007/s00428-007-0469-5, ISSN: 0945-6317.

Albert JM, Gonzalez A, Massion PP, Chen H, Olson SJ, Shyr Y, Diaz R, Lambright ES, Sandler A, Carbone DP, Putnam JB, Johnson DH, Lu B. Cytoplasmic clusterin expression is associated with longer survival in patients with resected non small cell lung cancer. Cancer Epidemiol. Biomarkers Prev. 2007 Sep; 16(9): 1845-51. PMID: 17855704, PII: 16/9/1845, DOI: 10.1158/1055-9965.EPI-07-0146, ISSN: 1055-9965.

Taguchi F, Solomon B, Gregorc V, Roder H, Gray R, Kasahara K, Nishio M, Brahmer J, Spreafico A, Ludovini V, Massion PP, Dziadziuszko R, Schiller J, Grigorieva J, Tsypin M, Hunsucker SW, Caprioli R, Duncan MW, Hirsch FR, Bunn PA, Carbone DP. Mass spectrometry to classify non-small-cell lung cancer patients for clinical outcome after treatment with epidermal growth factor receptor tyrosine kinase inhibitors: a multicohort cross-institutional study. J. Natl. Cancer Inst. 2007 Jun 6/6/2007; 99(11): 838-46. PMID: 17551144, PII: 99/11/838, DOI: 10.1093/jnci/djk195, ISSN: 1460-2105.

Massion PP, Caprioli RM. Proteomic strategies for the characterization and the early detection of lung cancer. J Thorac Oncol. 2006 Nov; 1(9): 1027-39. PMID: 17409991, PII: 01243894-200611000-00019, ISSN: 1556-1380.

Amann JM, Chaurand P, Gonzalez A, Mobley JA, Massion PP, Carbone DP, Caprioli RM. Selective profiling of proteins in lung cancer cells from fine-needle aspirates by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clin. Cancer Res. 2006 Sep 9/1/2006; 12(17): 5142-50. PMID: 16951232, PII: 12/17/5142, DOI: 10.1158/1078-0432.CCR-06-0264, ISSN: 1078-0432.

Stacy DR, Ely K, Massion PP, Yarbrough WG, Hallahan DE, Sekhar KR, Freeman ML. Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas. Head Neck. 2006 Sep; 28(9): 813-8. PMID: 16637057, DOI: 10.1002/hed.20430, ISSN: 1043-3074.

Rahman SM, Shyr Y, Yildiz PB, Gonzalez AL, Li H, Zhang X, Chaurand P, Yanagisawa K, Slovis BS, Miller RF, Ninan M, Miller YE, Franklin WA, Caprioli RM, Carbone DP, Massion PP. Proteomic patterns of preinvasive bronchial lesions. Am. J. Respir. Crit. Care Med [print-electronic]. 2005 Dec 12/15/2005; 172(12): 1556-62. PMID: 16179643, PMCID: PMC2718455, PII: 200502-274OC, DOI: 10.1164/rccm.200502-274OC, ISSN: 1073-449X.

Anumanthan G, Halder SK, Osada H, Takahashi T, Massion PP, Carbone DP, Datta PK. Restoration of TGF-beta signalling reduces tumorigenicity in human lung cancer cells. Br. J. Cancer. 2005 Nov 11/14/2005; 93(10): 1157-67. PMID: 16251876, PMCID: PMC2361493, PII: 6602831, DOI: 10.1038/sj.bjc.6602831, ISSN: 0007-0920.

Wardwell NR, Massion PP. Novel strategies for the early detection and prevention of lung cancer. Semin. Oncol. 2005 Jun; 32(3): 259-68. PMID: 15988680, PII: S0093775405000795, ISSN: 0093-7754.

Haruki N, Kawaguchi KS, Eichenberger S, Massion PP, Olson S, Gonzalez A, Carbone DP, Dang TP. Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers. Cancer Res. 2005 May 5/1/2005; 65(9): 3555-61. PMID: 15867348, PII: 65/9/3555, DOI: 10.1158/0008-5472.CAN-04-3132, ISSN: 0008-5472.

Shinohara ET, Gonzalez A, Massion PP, Chen H, Li M, Freyer AS, Olson SJ, Andersen JJ, Shyr Y, Carbone DP, Johnson DH, Hallahan DE, Lu B. Nuclear survivin predicts recurrence and poor survival in patients with resected nonsmall cell lung carcinoma. Cancer. 2005 Apr 4/15/2005; 103(8): 1685-92. PMID: 15742356, DOI: 10.1002/cncr.20951, ISSN: 0008-543X.

Amann J, Kalyankrishna S, Massion PP, Ohm JE, Girard L, Shigematsu H, Peyton M, Juroske D, Huang Y, Stuart Salmon J, Kim YH, Pollack JR, Yanagisawa K, Gazdar A, Minna JD, Kurie JM, Carbone DP. Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res. 2005 Jan 1/1/2005; 65(1): 226-35. PMID: 15665299, PII: 65/1/226, ISSN: 0008-5472.

Massion PP, Taflan PM, Shyr Y, Rahman SM, Yildiz P, Shakthour B, Edgerton ME, Ninan M, Andersen JJ, Gonzalez AL. Early involvement of the phosphatidylinositol 3-kinase/Akt pathway in lung cancer progression. Am. J. Respir. Crit. Care Med [print-electronic]. 2004 Nov 11/15/2004; 170(10): 1088-94. PMID: 15317667, PII: 200404-487OC, DOI: 10.1164/rccm.200404-487OC, ISSN: 1073-449X.

Lu B, Gonzalez A, Massion PP, Shyr Y, Shaktour B, Carbone DP, Hallahan DE. Nuclear survivin as a biomarker for non-small-cell lung cancer. Br. J. Cancer. 2004 Aug 8/2/2004; 91(3): 537-40. PMID: 15266313, PMCID: PMC2409840, PII: 6602027, DOI: 10.1038/sj.bjc.6602027, ISSN: 0007-0920.

Gonzalez AL, Roberts RL, Massion PP, Olson SJ, Shyr Y, Shappell SB. 15-Lipoxygenase-2 expression in benign and neoplastic lung: an immunohistochemical study and correlation with tumor grade and proliferation. Hum. Pathol. 2004 Jul; 35(7): 840-9. PMID: 15257547, PII: S0046817704002163, ISSN: 0046-8177.

Massion PP, Taflan PM, Rahman SM, Yildiz P, Shyr Y, Carbone DP, Gonzalez AL. Role of p63 amplification and overexpression in lung cancer development. Chest. 2004 May; 125(5 Suppl): 102S. PMID: 15136437, ISSN: 0012-3692.

Massion PP, Taflan PM, Jamshedur Rahman SM, Yildiz P, Shyr Y, Edgerton ME, Westfall MD, Roberts JR, Pietenpol JA, Carbone DP, Gonzalez AL. Significance of p63 amplification and overexpression in lung cancer development and prognosis. Cancer Res. 2003 Nov 11/1/2003; 63(21): 7113-21. PMID: 14612504, ISSN: 0008-5472.

Yanagisawa K, Shyr Y, Xu BJ, Massion PP, Larsen PH, White BC, Roberts JR, Edgerton M, Gonzalez A, Nadaf S, Moore JH, Caprioli RM, Carbone DP. Proteomic patterns of tumour subsets in non-small-cell lung cancer. Lancet. 2003 Aug 8/9/2003; 362(9382): 433-9. PMID: 12927430, PII: S0140-6736(03)14068-8, DOI: 10.1016/S0140-6736(03)14068-8, ISSN: 1474-547X.

Massion PP, Carbone DP. From clinical and pathologic to molecular staging of lung cancer [editorial]. Am. J. Respir. Crit. Care Med. 2003 Jun 6/15/2003; 167(12): 1587-8. PMID: 12796051, PII: 167/12/1587, DOI: 10.1164/rccm.2303006, ISSN: 1073-449X.

Massion PP, Carbone DP. The molecular basis of lung cancer: molecular abnormalities and therapeutic implications. Respir. Res [print-electronic]. 2003; 4: 12. PMID: 14641911, PMCID: PMC314397, PII: 1465-9921-4-12, DOI: 10.1186/1465-9921-4-12, ISSN: 1465-993X.

Massion PP, Kuo WL, Stokoe D, Olshen AB, Treseler PA, Chin K, Chen C, Polikoff D, Jain AN, Pinkel D, Albertson DG, Jablons DM, Gray JW. Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the phosphatidylinositol 3-kinase pathway. Cancer Res. 2002 Jul 7/1/2002; 62(13): 3636-40. PMID: 12097266, ISSN: 0008-5472.

Aliferis CF, Hardin D, Massion PP. Machine learning models for lung cancer classification using array comparative genomic hybridization. Proc AMIA Symp. 2002; 7-11. PMID: 12463776, PMCID: PMC2244172, PII: D020002392, ISSN: 1531-605X.

Godding V, Sibille Y, Massion PP, Delos M, Sibille C, Thurion P, Giffroy D, Langendries A, Vaerman JP. Secretory component production by human bronchial epithelial cells is upregulated by interferon gamma. Eur. Respir. J. 1998 May; 11(5): 1043-52. PMID: 9648953, ISSN: 0903-1936.

Massion PP, Lindén A, Inoue H, Mathy M, Grattan KM, Nadel JA. Dimethyl sulfoxide decreases interleukin-8-mediated neutrophil recruitment in the airways. Am. J. Physiol. 1996 Nov; 271(5 Pt 1): L838-43. PMID: 8944728, ISSN: 0002-9513.

Inoue H, Hara M, Massion PP, Grattan KM, Lausier JA, Chan B, Kaneko T, Isono K, Jorens PG, Ueki IF. Role of recruited neutrophils in interleukin-8 production in dog trachea after stimulation with Pseudomonas in vivo. Am. J. Respir. Cell Mol. Biol. 1995 Nov; 13(5): 570-7. PMID: 7576693, DOI: 10.1165/ajrcmb.13.5.7576693, ISSN: 1044-1549.

Yoshihara S, Chan B, Yamawaki I, Geppetti P, Ricciardolo FL, Massion PP, Nadel JA. Plasma extravasation in the rat trachea induced by cold air is mediated by tachykinin release from sensory nerves. Am. J. Respir. Crit. Care Med. 1995 Apr; 151(4): 1011-7. PMID: 7697224, DOI: 10.1164/ajrccm/151.4.1011, ISSN: 1073-449X.

Massion PP, Hébert CA, Leong S, Chan B, Inoue H, Grattan K, Sheppard D, Nadel JA. Staphylococcus aureus stimulates neutrophil recruitment by stimulating interleukin-8 production in dog trachea. Am. J. Physiol. 1995 Jan; 268(1 Pt 1): L85-94. PMID: 7840233, ISSN: 0002-9513.

Inoue H, Massion PP, Ueki IF, Grattan KM, Hara M, Dohrman AF, Chan B, Lausier JA, Golden JA, Nadel JA. Pseudomonas stimulates interleukin-8 mRNA expression selectively in airway epithelium, in gland ducts, and in recruited neutrophils. Am. J. Respir. Cell Mol. Biol. 1994 Dec; 11(6): 651-63. PMID: 7946394, DOI: 10.1165/ajrcmb.11.6.7946394, ISSN: 1044-1549.

Jorens PG, Richman-Eisenstat JB, Housset BP, Massion PP, Ueki I, Nadel JA. Pseudomonas-induced neutrophil recruitment in the dog airway in vivo is mediated in part by IL-8 and inhibited by a leumedin. Eur. Respir. J. 1994 Nov; 7(11): 1925-31. PMID: 7875261, ISSN: 0903-1936.

Massion PP, Inoue H, Richman-Eisenstat J, Grunberger D, Jorens PG, Housset B, Pittet JF, Wiener-Kronish JP, Nadel JA. Novel Pseudomonas product stimulates interleukin-8 production in airway epithelial cells in vitro. J. Clin. Invest. 1994 Jan; 93(1): 26-32. PMID: 8282796, PMCID: PMC293717, DOI: 10.1172/JCI116954, ISSN: 0021-9738.

Massion PP, Funari CC, Ueki I, Ikeda S, McDonald DM, Nadel JA. Parainfluenza (Sendai) virus infects ciliated cells and secretory cells but not basal cells of rat tracheal epithelium. Am. J. Respir. Cell Mol. Biol. 1993 Oct; 9(4): 361-70. PMID: 8398175, DOI: 10.1165/ajrcmb/9.4.361, ISSN: 1044-1549.