R. Stokes Peebles, M.D.

Professor

stokes.peebles@vanderbilt.edu
Faculty Appointments
Professor of Medicine Professor of Pathology, Microbiology and ImmunologyElizabeth and John Murray Chair in Medicine
Education
M.D., Medicine , Vanderbilt University, Nashville, TennesseeB.S., Davidson College, Davidson, North Carolina
Office Address
T-1218 MCN
Vanderbilt University Medical Center
1161 21st Avenue South
Nashville, TN 37232-2650
Research Keywords
Our lab is interested in allergically-mediated and virally-induced lung inflammation. Presently funded projects include how IL-17 and PGI2 mediate inflammatory responses.
Publications
Newcomb DC, Cephus JY, Boswell MG, Fahrenholz JM, Langley EW, Feldman AS, Zhou W, Dulek DE, Goleniewska K, Woodward KB, Sevin CM, Hamilton RG, Kolls JK, Peebles RS. Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma. J. Allergy Clin. Immunol [print-electronic]. 2015 Oct; 136(4): 1025-1034.e11. PMID: 26242299, PMCID: PMC4600442, PII: S0091-6749(15)00840-4, DOI: 10.1016/j.jaci.2015.05.046, ISSN: 1097-6825.

Zaynagetdinov R, Sherrill TP, Gleaves LA, McLoed AG, Saxon JA, Habermann AC, Connelly L, Dulek D, Peebles RS, Fingleton B, Yull FE, Stathopoulos GT, Blackwell TS. Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment. Cancer Res [print-electronic]. 2015 Apr 4/15/2015; 75(8): 1624-34. PMID: 25691457, PMCID: PMC4401663, PII: 0008-5472.CAN-14-2379, DOI: 10.1158/0008-5472.CAN-14-2379, ISSN: 1538-7445.

Peebles RS. At the bedside: the emergence of group 2 innate lymphoid cells in human disease. J. Leukoc. Biol [print-electronic]. 2015 Mar; 97(3): 469-75. PMID: 25516755, PMCID: PMC4338848, PII: jlb.3BT0814-383R, DOI: 10.1189/jlb.3BT0814-383R, ISSN: 1938-3673.

Claar D, Hartert TV, Peebles RS. The role of prostaglandins in allergic lung inflammation and asthma. Expert Rev Respir Med [print-electronic]. 2015 Feb; 9(1): 55-72. PMID: 25541289, PMCID: PMC4380345, DOI: 10.1586/17476348.2015.992783, ISSN: 1747-6356.

Karlin E, Gebretsadik T, Peebles RS, Hartert TV, Langley EW, Arnold DH. Fractional exhaled nitric oxide change in pediatric patients after emergency department care of asthma exacerbations [letter]. Ann. Allergy Asthma Immunol [print-electronic]. 2015 Feb; 114(2): 149-51. PMID: 25492099, PII: S1081-1206(14)00804-7, DOI: 10.1016/j.anai.2014.11.002, ISSN: 1534-4436.

Larkin EK, Gebretsadik T, Moore ML, Anderson LJ, Dupont WD, Chappell JD, Minton PA, Peebles RS, Moore PE, Valet RS, Arnold DH, Rosas-Salazar C, Das SR, Polack FP, Hartert TV, . Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE). BMC Pulm Med. 2015; 15: 45. PMID: 26021723, PMCID: PMC4506623, PII: 10.1186/s12890-015-0040-0, DOI: 10.1186/s12890-015-0040-0, ISSN: 1471-2466.

Hotard AL, Lee S, Currier MG, Crowe JE, Sakamoto K, Newcomb DC, Peebles RS, Plemper RK, Moore ML. Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis. J. Virol [print-electronic]. 2015 Jan; 89(1): 512-22. PMID: 25339762, PMCID: PMC4301159, PII: JVI.02472-14, DOI: 10.1128/JVI.02472-14, ISSN: 1098-5514.

Patel DA, You Y, Huang G, Byers DE, Kim HJ, Agapov E, Moore ML, Peebles RS, Castro M, Sumino K, Shifren A, Brody SL, Holtzman MJ. Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma. J. Allergy Clin. Immunol [print-electronic]. 2014 Dec; 134(6): 1402-1412.e7. PMID: 25216987, PMCID: PMC4261010, PII: S0091-6749(14)00968-3, DOI: 10.1016/j.jaci.2014.07.013, ISSN: 1097-6825.

Langley EW, Gebretsadik T, Hartert TV, Peebles RS, Arnold DH. Exhaled nitric oxide is associated with severity of pediatric acute asthma exacerbations. J Allergy Clin Immunol Pract [print-electronic]. 2014 Sep; 2(5): 618-20.e1. PMID: 25213059, PMCID: PMC4163006, PII: S2213-2198(14)00141-X, DOI: 10.1016/j.jaip.2014.04.004, ISSN: 2213-2201.

Miller EK, Avila PC, Khan YW, Word CR, Pelz BJ, Papadopoulos NG, Peebles RS, Heymann PW, . Wheezing exacerbations in early childhood: evaluation, treatment, and recent advances relevant to the genesis of asthma. J Allergy Clin Immunol Pract. 2014 Sep; 2(5): 537-43. PMID: 25213046, PMCID: PMC4190166, PII: S2213-2198(14)00305-5, DOI: 10.1016/j.jaip.2014.06.024, ISSN: 2213-2201.

Zhou W, Goleniewska K, Zhang J, Dulek DE, Toki S, Lotz MT, Newcomb DC, Boswell MG, Polosukhin VV, Milne GL, Wu P, Moore ML, FitzGerald GA, Peebles RS. Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling. J. Allergy Clin. Immunol [print-electronic]. 2014 Sep; 134(3): 698-705.e5. PMID: 25042746, PMCID: PMC4358822, PII: S0091-6749(14)00806-9, DOI: 10.1016/j.jaci.2014.06.004, ISSN: 1097-6825.

Dulek DE, Newcomb DC, Goleniewska K, Cephus J, Zhou W, Reiss S, Toki S, Ye F, Zaynagetdinov R, Sherrill TP, Blackwell TS, Moore ML, Boyd KL, Kolls JK, Peebles RS. Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner. Infect. Immun [print-electronic]. 2014 Sep; 82(9): 3723-39. PMID: 24958709, PMCID: PMC4187810, PII: IAI.00035-14, DOI: 10.1128/IAI.00035-14, ISSN: 1098-5522.

Dulek DE, Newcomb DC, Toki S, Goliniewska K, Cephus J, Reiss S, Bates JT, Crowe JE, Boyd KL, Moore ML, Zhou W, Peebles RS. STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. J. Virol [print-electronic]. 2014 Sep 9/1/2014; 88(17): 9655-72. PMID: 24920804, PMCID: PMC4136353, PII: JVI.03299-13, DOI: 10.1128/JVI.03299-13, ISSN: 1098-5514.

Newcomb DC, Peebles RS. Th17-mediated inflammation in asthma. Curr. Opin. Immunol [print-electronic]. 2013 Dec; 25(6): 755-60. PMID: 24035139, PMCID: PMC3855890, PII: S0952-7915(13)00130-1, DOI: 10.1016/j.coi.2013.08.002, ISSN: 1879-0372.

Toki S, Omary RA, Wilson K, Gore JC, Peebles RS, Pham W. A comprehensive analysis of transfection-assisted delivery of iron oxide nanoparticles to dendritic cells. Nanomedicine [print-electronic]. 2013 Nov; 9(8): 1235-44. PMID: 23747738, PMCID: PMC4031028, PII: S1549-9634(13)00261-X, DOI: 10.1016/j.nano.2013.05.010, ISSN: 1549-9642.

Sevin CM, Newcomb DC, Toki S, Han W, Sherrill TP, Boswell MG, Zhu Z, Collins RD, Boyd KL, Goleniewska K, Huckabee MM, Blackwell TS, Peebles RS. Deficiency of gp91phox inhibits allergic airway inflammation. Am. J. Respir. Cell Mol. Biol. 2013 Sep; 49(3): 396-402. PMID: 23590311, PMCID: PMC3824054, DOI: 10.1165/rcmb.2012-0442OC, ISSN: 1535-4989.

Newcomb DC, Boswell MG, Reiss S, Zhou W, Goleniewska K, Toki S, Harintho MT, Lukacs NW, Kolls JK, Peebles RS. IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation. Thorax [print-electronic]. 2013 Aug; 68(8): 717-23. PMID: 23422214, PMCID: PMC3916091, PII: thoraxjnl-2012-202404, DOI: 10.1136/thoraxjnl-2012-202404, ISSN: 1468-3296.

Toki S, Goleniewska K, Huckabee MM, Zhou W, Newcomb DC, Fitzgerald GA, Lawson WE, Peebles RS. PGI2 signaling inhibits antigen uptake and increases migration of immature dendritic cells. J. Leukoc. Biol [print-electronic]. 2013 Jul; 94(1): 77-88. PMID: 23625201, PMCID: PMC3685021, PII: jlb.1112559, DOI: 10.1189/jlb.1112559, ISSN: 1938-3673.

Newcomb DC, Boswell MG, Sherrill TP, Polosukhin VV, Boyd KL, Goleniewska K, Brody SL, Kolls JK, Adler KB, Peebles RS. IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia. Am. J. Respir. Cell Mol. Biol. 2013 Jun; 48(6): 711-6. PMID: 23392574, PMCID: PMC3727878, PII: rcmb.2013-0017OC, DOI: 10.1165/rcmb.2013-0017OC, ISSN: 1535-4989.

Peebles RS. A new horizon in asthma: inhibiting ILC function. Sci Transl Med. 2013 Feb 2/27/2013; 5(174): 174fs7. PMID: 23447016, PII: 5/174/174fs7, DOI: 10.1126/scitranslmed.3005881, ISSN: 1946-6242.

Rosen MJ, Chaturvedi R, Washington MK, Kuhnhein LA, Moore PD, Coggeshall SS, McDonough EM, Weitkamp JH, Singh AB, Coburn LA, Williams CS, Yan F, Van Kaer L, Peebles RS, Wilson KT. STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. J. Immunol [print-electronic]. 2013 Feb 2/15/2013; 190(4): 1849-58. PMID: 23303670, PMCID: PMC3563924, PII: jimmunol.1201373, DOI: 10.4049/jimmunol.1201373, ISSN: 1550-6606.

Lotz MT, Moore ML, Peebles RS. Respiratory syncytial virus and reactive airway disease. Curr. Top. Microbiol. Immunol. 2013; 372: 105-18. PMID: 24362686, PMCID: PMC4322419, DOI: 10.1007/978-3-642-38919-1_5, ISSN: 0070-217X.

Lotz MT, Peebles RS. Mechanisms of respiratory syncytial virus modulation of airway immune responses. Curr Allergy Asthma Rep. 2012 Oct; 12(5): 380-7. PMID: 22692775, PMCID: PMC3432290, DOI: 10.1007/s11882-012-0278-z, ISSN: 1534-6315.

James KM, Peebles RS, Hartert TV. Response to infections in patients with asthma and atopic disease: an epiphenomenon or reflection of host susceptibility?. J. Allergy Clin. Immunol. 2012 Aug; 130(2): 343-51. PMID: 22846746, PMCID: PMC3410318, PII: S0091-6749(12)01031-7, DOI: 10.1016/j.jaci.2012.05.056, ISSN: 1097-6825.

Zaynagetdinov R, Stathopoulos GT, Sherrill TP, Cheng DS, McLoed AG, Ausborn JA, Polosukhin VV, Connelly L, Zhou W, Fingleton B, Peebles RS, Prince LS, Yull FE, Blackwell TS. Epithelial nuclear factor-¿B signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene [print-electronic]. 2012 Jun 6/28/2012; 31(26): 3164-76. PMID: 22002309, PMCID: PMC3266969, PII: onc2011480, DOI: 10.1038/onc.2011.480, ISSN: 1476-5594.

Newcomb DC, Boswell MG, Huckabee MM, Goleniewska K, Dulek DE, Reiss S, Lukacs NW, Kolls JK, Peebles RS. IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner. J. Immunol [print-electronic]. 2012 Feb 2/1/2012; 188(3): 1027-35. PMID: 22210911, PMCID: PMC3262924, PII: jimmunol.1102216, DOI: 10.4049/jimmunol.1102216, ISSN: 1550-6606.

Zhou W, Dowell DR, Huckabee MM, Newcomb DC, Boswell MG, Goleniewska K, Lotz MT, Toki S, Yin H, Yao S, Natarajan C, Wu P, Sriram S, Breyer RM, Fitzgerald GA, Peebles RS. Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis. PLoS ONE [print-electronic]. 2012; 7(5): e33518. PMID: 22590492, PMCID: PMC3349674, PII: PONE-D-10-03779, DOI: 10.1371/journal.pone.0033518, ISSN: 1932-6203.

Dorris SL, Peebles RS. PGI2 as a regulator of inflammatory diseases. Mediators Inflamm [print-electronic]. 2012; 2012: 926968. PMID: 22851816, PMCID: PMC3407649, DOI: 10.1155/2012/926968, ISSN: 1466-1861.

Boswell MG, Zhou W, Newcomb DC, Peebles RS. PGI2 as a regulator of CD4+ subset differentiation and function. Prostaglandins Other Lipid Mediat [print-electronic]. 2011 Nov; 96(1-4): 21-6. PMID: 21864703, PMCID: PMC3215832, PII: S1098-8823(11)00073-6, DOI: 10.1016/j.prostaglandins.2011.08.003, ISSN: 1098-8823.

Dulek DE, Peebles RS. Viruses and asthma. Biochim. Biophys. Acta [print-electronic]. 2011 Nov; 1810(11): 1080-90. PMID: 21291960, PMCID: PMC3130828, PII: S0304-4165(11)00031-6, DOI: 10.1016/j.bbagen.2011.01.012, ISSN: 0006-3002.

Zhou W, Dowell DR, Geraci MW, Blackwell TS, Collins RD, Polosukhin VV, Lawson WE, Wu P, Sussan T, Biswal S, Goleniewska K, O'Neal J, Newcomb DC, Toki S, Morrow JD, Peebles RS. PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2011 Oct; 301(4): L615-22. PMID: 21764988, PMCID: PMC3774255, PII: ajplung.00224.2010, DOI: 10.1152/ajplung.00224.2010, ISSN: 1522-1504.

Dulek DE, Peebles RS. Bacteria and asthma: more there than we thought. Expert Rev Respir Med. 2011 Jun; 5(3): 329-32. PMID: 21702654, PMCID: PMC3929126, DOI: 10.1586/ers.11.33, ISSN: 1747-6356.

Newcomb DC, Boswell MG, Zhou W, Huckabee MM, Goleniewska K, Sevin CM, Hershey GK, Kolls JK, Peebles RS. Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production. J. Allergy Clin. Immunol [print-electronic]. 2011 Apr; 127(4): 1006-13.e1. PMID: 21236478, PMCID: PMC3916096, PII: S0091-6749(10)01865-8, DOI: 10.1016/j.jaci.2010.11.043, ISSN: 1097-6825.

Stathopoulos GT, Sherrill TP, Karabela SP, Goleniewska K, Kalomenidis I, Roussos C, Fingleton B, Yull FE, Peebles RS, Blackwell TS. Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion. Am. J. Respir. Crit. Care Med [print-electronic]. 2010 Nov 11/15/2010; 182(10): 1273-81. PMID: 20595227, PMCID: PMC3001265, PII: 201001-0001OC, DOI: 10.1164/rccm.201001-0001OC, ISSN: 1535-4970.

Westerly BD, Peebles RS. Respiratory syncytial virus infections in the adult asthmatic--mechanisms of host susceptibility and viral subversion. Immunol Allergy Clin North Am [print-electronic]. 2010 Nov; 30(4): 523-39, vi. PMID: 21029936, PMCID: PMC2966842, PII: S0889-8561(10)00070-6, DOI: 10.1016/j.iac.2010.08.006, ISSN: 1557-8607.

Sevin CM, Peebles RS. Infections and asthma: new insights into old ideas. Clin. Exp. Allergy. 2010 Aug; 40(8): 1142-54. PMID: 20649609, PII: CEA3563, DOI: 10.1111/j.1365-2222.2010.03563.x, ISSN: 1365-2222.

Hartert TV, Carroll K, Gebretsadik T, Woodward K, Minton P, . The Tennessee Children's Respiratory Initiative: Objectives, design and recruitment results of a prospective cohort study investigating infant viral respiratory illness and the development of asthma and allergic diseases. Respirology [print-electronic]. 2010 May; 15(4): 691-9. PMID: 20409023, PMCID: PMC2992986, PII: RES1743, DOI: 10.1111/j.1440-1843.2010.01743.x, ISSN: 1440-1843.

Zaynagetdinov R, Ryzhov S, Goldstein AE, Yin H, Novitskiy SV, Goleniewska K, Polosukhin VV, Newcomb DC, Mitchell D, Morschl E, Zhou Y, Blackburn MR, Peebles RS, Biaggioni I, Feoktistov I. Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2010 May; 42(5): 564-71. PMID: 19556606, PMCID: PMC2874442, PII: 2008-0391OC, DOI: 10.1165/rcmb.2008-0391OC, ISSN: 1535-4989.

Sheller JR, Polosukhin VV, Mitchell D, Cheng DS, Peebles RS, Blackwell TS. Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice. Exp. Lung Res. 2009 Dec; 35(10): 883-95. PMID: 19995280, PMCID: PMC3419942, DOI: 10.3109/01902140903019710, ISSN: 1521-0499.

Yin H, Liu W, Goleniewska K, Porter NA, Morrow JD, Peebles RS. Dietary supplementation of omega-3 fatty acid-containing fish oil suppresses F2-isoprostanes but enhances inflammatory cytokine response in a mouse model of ovalbumin-induced allergic lung inflammation. Free Radic. Biol. Med [print-electronic]. 2009 Sep 9/1/2009; 47(5): 622-8. PMID: 19501157, PMCID: PMC2716436, PII: S0891-5849(09)00332-3, DOI: 10.1016/j.freeradbiomed.2009.05.033, ISSN: 1873-4596.

Moore ML, Newcomb DC, Parekh VV, Van Kaer L, Collins RD, Zhou W, Goleniewska K, Chi MH, Mitchell D, Boyce JA, Durbin JE, Sturkie C, Peebles RS. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J. Immunol [print-electronic]. 2009 Aug 8/1/2009; 183(3): 2016-26. PMID: 19587017, PMCID: PMC3755459, PII: jimmunol.0803167, DOI: 10.4049/jimmunol.0803167, ISSN: 1550-6606.

Newcomb DC, Peebles RS. Bugs and asthma: a different disease?. Proc Am Thorac Soc. 2009 May 5/1/2009; 6(3): 266-71. PMID: 19387028, PMCID: PMC2677401, PII: 6/3/266, DOI: 10.1513/pats.200806-056RM, ISSN: 1546-3222.

Newcomb DC, Zhou W, Moore ML, Goleniewska K, Hershey GK, Kolls JK, Peebles RS. A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production. J. Immunol. 2009 May 5/1/2009; 182(9): 5317-21. PMID: 19380778, PMCID: PMC3711250, PII: 182/9/5317, DOI: 10.4049/jimmunol.0803868, ISSN: 1550-6606.

Moore ML, Chi MH, Luongo C, Lukacs NW, Polosukhin VV, Huckabee MM, Newcomb DC, Buchholz UJ, Crowe JE, Goleniewska K, Williams JV, Collins PL, Peebles RS. A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction. J. Virol [print-electronic]. 2009 May; 83(9): 4185-94. PMID: 19211758, PMCID: PMC2668460, PII: JVI.01853-08, DOI: 10.1128/JVI.01853-08, ISSN: 1098-5514.

Huckabee MM, Peebles RS. Novel concepts in virally induced asthma. Clin Mol Allergy. 2009; 7: 2. PMID: 19154602, PMCID: PMC2651109, PII: 1476-7961-7-2, DOI: 10.1186/1476-7961-7-2, ISSN: 1476-7961.

Hashimoto K, Ishibashi K, Gebretsadik T, Hartert TV, Yamamoto A, Nakayama T, Ohashi K, Sakata H, Kawasaki Y, Katayose M, Sakuma H, Suzuki H, Hosoya M, Peebles RS, Suzutani T. Functional polymorphism of the promoter region of the prostacyclin synthase gene and severity of RSV infection in hospitalized children. J. Med. Virol. 2008 Nov; 80(11): 2015-22. PMID: 18814254, DOI: 10.1002/jmv.21318, ISSN: 1096-9071.

Zhou W, Newcomb DC, Moore ML, Goleniewska K, O'Neal JF, Peebles RS. Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses. J. Immunol. 2008 Oct 10/15/2008; 181(8): 5360-7. PMID: 18832692, PII: 181/8/5360, ISSN: 1550-6606.

Moore ML, Chi MH, Goleniewska K, Durbin JE, Peebles RS. Differential regulation of GM1 and asialo-GM1 expression by T cells and natural killer (NK) cells in respiratory syncytial virus infection. Viral Immunol. 2008 Sep; 21(3): 327-39. PMID: 18788941, PMCID: PMC2952133, DOI: 10.1089/vim.2008.0003, ISSN: 1557-8976.

Temiño VM, Peebles RS. The spectrum and treatment of angioedema. Am. J. Med. 2008 Apr; 121(4): 282-6. PMID: 18374684, PII: S0002-9343(07)01091-1, DOI: 10.1016/j.amjmed.2007.09.024, ISSN: 1555-7162.

Rudd BD, Luker GD, Luker KE, Peebles RS, Lukacs NW. Type I interferon regulates respiratory virus infected dendritic cell maturation and cytokine production. Viral Immunol. 2007 Dec; 20(4): 531-40. PMID: 18158727, DOI: 10.1089/vim.2007.0057, ISSN: 0882-8245.

Peebles RS, Moore ML. A mechanistic advance in understanding RSV pathogenesis, but still a long way from therapy [editorial]. Am. J. Respir. Cell Mol. Biol. 2007 Oct; 37(4): 375-7. PMID: 17872592, PII: 37/4/375, DOI: 10.1165/rcmb.2007-0003ED, ISSN: 1044-1549.

Sadikot RT, Zeng H, Azim AC, Joo M, Dey SK, Breyer RM, Peebles RS, Blackwell TS, Christman JW. Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2. Eur. J. Immunol. 2007 Apr; 37(4): 1001-9. PMID: 17330822, DOI: 10.1002/eji.200636636, ISSN: 0014-2980.

Zhou W, Blackwell TS, Goleniewska K, O'Neal JF, Fitzgerald GA, Lucitt M, Breyer RM, Peebles RS. Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells. J. Leukoc. Biol [print-electronic]. 2007 Mar; 81(3): 809-17. PMID: 17135575, PII: jlb.0606375, DOI: 10.1189/jlb.0606375, ISSN: 0741-5400.

Moore ML, Chi MH, Zhou W, Goleniewska K, O'Neal JF, Higginbotham JN, Peebles RS. Cutting Edge: Oseltamivir decreases T cell GM1 expression and inhibits clearance of respiratory syncytial virus: potential role of endogenous sialidase in antiviral immunity. J. Immunol. 2007 Mar 3/1/2007; 178(5): 2651-4. PMID: 17312105, PII: 178/5/2651, ISSN: 0022-1767.

Zhou W, Hashimoto K, Goleniewska K, O'Neal JF, Ji S, Blackwell TS, Fitzgerald GA, Egan KM, Geraci MW, Peebles RS. Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. J. Immunol. 2007 Jan 1/15/2007; 178(2): 702-10. PMID: 17202330, PII: 178/2/702, ISSN: 0022-1767.

Moore ML, Peebles RS. Respiratory syncytial virus disease mechanisms implicated by human, animal model, and in vitro data facilitate vaccine strategies and new therapeutics. Pharmacol. Ther [print-electronic]. 2006 Nov; 112(2): 405-24. PMID: 16820210, PII: S0163-7258(06)00067-2, DOI: 10.1016/j.pharmthera.2006.04.008, ISSN: 0163-7258.

Moore PE, Cunningham G, Calder MM, DeMatteo AD, Peeples ME, Summar ML, Peebles RS. Respiratory syncytial virus infection reduces beta2-adrenergic responses in human airway smooth muscle. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2006 Nov; 35(5): 559-64. PMID: 16763224, PMCID: PMC2643275, PII: 2005-0282OC, DOI: 10.1165/rcmb.2005-0282OC, ISSN: 1044-1549.

Zhou W, Hashimoto K, Moore ML, Elias JA, Zhu Z, Durbin J, Colasurdo G, Rutigliano JA, Chiappetta CL, Goleniewska K, O'Neal JF, Graham BS, Peebles RS. IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse. Microbes Infect [print-electronic]. 2006 Nov; 8(14-15): 2880-9. PMID: 17110149, PMCID: PMC1811125, PII: S1286-4579(06)00351-0, DOI: 10.1016/j.micinf.2006.09.007, ISSN: 1286-4579.

Lukacs NW, Moore ML, Rudd BD, Berlin AA, Collins RD, Olson SJ, Ho SB, Peebles RS. Differential immune responses and pulmonary pathophysiology are induced by two different strains of respiratory syncytial virus. Am. J. Pathol. 2006 Sep; 169(3): 977-86. PMID: 16936271, PMCID: PMC1698832, PII: S0002-9440(10)62773-3, DOI: 10.2353/ajpath.2006.051055, ISSN: 0002-9440.

Moore ML, Peebles RS. Update on the role of prostaglandins in allergic lung inflammation: separating friends from foes, harder than you might think. J. Allergy Clin. Immunol [print-electronic]. 2006 May; 117(5): 1036-9. PMID: 16675329, PII: S0091-6749(05)04039-X, DOI: 10.1016/j.jaci.2005.12.1314, ISSN: 0091-6749.

Peebles RS, Hashimoto K, Sheller JR, Moore ML, Morrow JD, Ji S, Elias JA, Goleniewska K, O'neal J, Mitchell DB, Graham BS, Zhou W. Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent. J. Immunol. 2005 Dec 12/15/2005; 175(12): 8253-9. PMID: 16339565, PII: 175/12/8253, ISSN: 0022-1767.

Kalomenidis I, Guo Y, Peebles RS, Lane KB, Papiris S, Elias J, Light RW. Pneumothorax-associated pleural eosinophilia in mice is interleukin-5 but not interleukin-13 dependent. Chest. 2005 Oct; 128(4): 2978-83. PMID: 16236975, PII: 128/4/2978, DOI: 10.1378/chest.128.4.2978, ISSN: 0012-3692.

Hashimoto K, Durbin JE, Zhou W, Collins RD, Ho SB, Kolls JK, Dubin PJ, Sheller JR, Goleniewska K, O'Neal JF, Olson SJ, Mitchell D, Graham BS, Peebles RS. Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels. J. Allergy Clin. Immunol. 2005 Sep; 116(3): 550-7. PMID: 16159623, PII: S0091-6749(05)01278-9, DOI: 10.1016/j.jaci.2005.03.051, ISSN: 0091-6749.

Hashimoto K, Sheller JR, Morrow JD, Collins RD, Goleniewska K, O'Neal J, Zhou W, Ji S, Mitchell DB, Graham BS, Peebles RS. Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms. J. Immunol. 2005 Jan 1/1/2005; 174(1): 525-32. PMID: 15611279, PII: 174/1/525, ISSN: 0022-1767.

Hashimoto K, Graham BS, Geraci MW, FitzGerald GA, Egan K, Zhou W, Goleniewska K, O'Neal JF, Morrow JD, Durbin RK, Wright PF, Collins RD, Suzutani T, Peebles RS. Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness. J. Virol. 2004 Oct; 78(19): 10303-9. PMID: 15367596, PMCID: PMC516432, PII: 78/19/10303, DOI: 10.1128/JVI.78.19.10303-10309.2004, ISSN: 0022-538X.

Hashimoto K, Graham BS, Ho SB, Adler KB, Collins RD, Olson SJ, Zhou W, Suzutani T, Jones PW, Goleniewska K, O'Neal JF, Peebles RS. Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5. Am. J. Respir. Crit. Care Med [print-electronic]. 2004 Aug 8/1/2004; 170(3): 306-12. PMID: 15130904, PII: 200301-030OC, DOI: 10.1164/rccm.200301-030OC, ISSN: 1073-449X.

Available Postdoctoral Position Details
Posted: 3/5/2013
Post-doctoral research fellow position will be open in Sepetmber 2009. Funding will be provided by the Peebles lab; however, the expectation is that the candidate will be eligible for an NIH F32 or T32 grant. Our lab has a strong track record in obtaining these grants for post-doctoral fellows.