Dan M. Spengler, M.D.



Visit Lab Site

Faculty Appointments
Professor of Orthopaedic Surgery and Rehabilitation Professor of Neurological Surgery
M.D., MEDICINE, University of Michigan, Ann Arbor, MichiganB.S., Chemistry, Baldwin-Wallace College, Berea, Ohio
Office Address
Suite 4200 Med Center East, South Tower
Nashville, TN 8774
Clinical Research Keywords
adult spine, spinal injuries
Yoshii T, Hafeman AE, Nyman JS, Esparza JM, Shinomiya K, Spengler DM, Mundy GR, Gutierrez GE, Guelcher SA. A sustained release of lovastatin from biodegradable, elastomeric polyurethane scaffolds for enhanced bone regeneration. Tissue Eng Part A. 2010 Jul; 16(7): 2369-79. PMID: 20205517, DOI: 10.1089/ten.TEA.2009.0585, ISSN: 1937-335X.

Spengler DM. Vertebroplasty was not effective for painful osteoporotic vertebral fractures. J Bone Joint Surg Am. 2010 May; 92(5): 1263. PMID: 20439677, PII: 92/5/1263, DOI: 10.2106/JBJS.9205.ebo443, ISSN: 1535-1386.

Spengler DM. Surgery reduced pain at two years but did not differ from nonsurgical treatment for physical function in lumbar spinal stenosis. J Bone Joint Surg Am. 2008 Nov; 90(11): 2553. PMID: 18978436, PII: 90/11/2553, DOI: 10.2106/JBJS.9011.ebo1, ISSN: 1535-1386.

Sanders NW, Mann NH, Spengler DM. Pain drawing scoring is not improved by inclusion of patient-reported pain sensation. Spine. 2006 Nov 11/1/2006; 31(23): 2735-41; discussion 2742. PMID: 17077744, PII: 00007632-200611010-00016, DOI: 10.1097/01.brs.0000244674.99258.f9, ISSN: 1528-1159.

Spengler DM. Great to greater: opportunities and challenges for the American Orthopaedic Association in the early twenty-first century. Challenges in our academic mission. J Bone Joint Surg Am. 2003 Dec; 85-A(12): 2471-6. PMID: 14668522, ISSN: 0021-9355.

Throckmorton TW, Hilibrand AS, Mencio GA, Hodge A, Spengler DM. The impact of adjacent level disc degeneration on health status outcomes following lumbar fusion. Spine. 2003 Nov 11/15/2003; 28(22): 2546-50. PMID: 14624093, DOI: 10.1097/01.BRS.0000092340.24070.F3, ISSN: 1528-1159.

Rohmiller MT, Schwalm D, Glattes RC, Elalayli TG, Spengler DM. Evaluation of calcium sulfate paste for augmentation of lumbar pedicle screw pullout strength. Spine J. 2002 Jul; 2(4): 255-60. PMID: 14589476, PII: S1529943002002073, ISSN: 1529-9430.

Rand NS, Dawson JM, Juliao SF, Spengler DM, Floman Y. In vivo macrophage recruitment by murine intervertebral disc cells. J Spinal Disord. 2001 Aug; 14(4): 339-42. PMID: 11481557, ISSN: 0895-0385.

Elder SH, Goldstein SA, Kimura JH, Soslowsky LJ, Spengler DM. Chondrocyte differentiation is modulated by frequency and duration of cyclic compressive loading. Ann Biomed Eng. 2001 Jun; 29(6): 476-82. PMID: 11459341, ISSN: 0090-6964.

Haro H, Crawford HC, Fingleton B, Shinomiya K, Spengler DM, Matrisian LM. Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption. J. Clin. Invest. 2000 Jan; 105(2): 143-50. PMID: 10642592, PMCID: PMC377426, DOI: 10.1172/JCI7091, ISSN: 0021-9738.

Haro H, Crawford HC, Fingleton B, MacDougall JR, Shinomiya K, Spengler DM, Matrisian LM. Matrix metalloproteinase-3-dependent generation of a macrophage chemoattractant in a model of herniated disc resorption. J. Clin. Invest. 2000 Jan; 105(2): 133-41. PMID: 10642591, PMCID: PMC377425, DOI: 10.1172/JCI7090, ISSN: 0021-9738.

Haro H, Shinomiya K, Murakami S, Spengler DM. Up-regulated expression of matrilysin and neutrophil collagenase in human herniated discs. J Spinal Disord. 1999 Jun; 12(3): 245-9. PMID: 10382779, ISSN: 0895-0385.

Klekamp J, Spengler DM, McNamara MJ, Haas DW. Risk factors associated with methicillin-resistant staphylococcal wound infection after spinal surgery. J Spinal Disord. 1999 Jun; 12(3): 187-91. PMID: 10382770, ISSN: 0895-0385.

Schwartz HS, Spengler DM. Needle tract recurrences after closed biopsy for sarcoma: three cases and review of the literature. Ann. Surg. Oncol. 1997 Apr; 4(3): 228-36. PMID: 9142384, ISSN: 1068-9265.

Weisberg NK, Spengler DM, Netterville JL. Stretch-induced nerve injury as a cause of paralysis secondary to the anterior cervical approach. Otolaryngol Head Neck Surg. 1997 Mar; 116(3): 317-26. PMID: 9121783, PII: a76369, ISSN: 0194-5998.

Sanders NW, Mann NH, Spengler DM. Web client and ODBC access to legacy database information: a low cost approach. Proc AMIA Annu Fall Symp. 1997; 799-803. PMID: 9357735, PMCID: PMC2233436, ISSN: 1091-8280.

Westberg EE, Mann NH, Spengler DM. Integrating and presenting clinical and treatment outcome data for cost-effective case management. Comput. Biol. Med. 1997 Jan; 27(1): 31-47. PMID: 9055044, PII: S0010482596000716, ISSN: 0010-4825.

Shinomiya K, Dawson J, Spengler DM, Konrad P, Blumenkopf B. An analysis of the posterior epidural ligament role on the cervical spinal cord. Spine. 1996 Sep 9/15/1996; 21(18): 2081-8. PMID: 8893431, ISSN: 0362-2436.

Dawson JM, DeBoer DK, Spengler DM, Schwartz HS. The spinal nail: a new implant for short-segment anterior instrumentation of the thoracolumbar spine. J Spinal Disord. 1996 Aug; 9(4): 299-305. PMID: 8877956, ISSN: 0895-0385.

Shinomiya K, Sato T, Spengler DM, Dawson J. Isolated muscle atrophy of the distal upper extremity in cervical spinal cord compressive disorders. J Spinal Disord. 1995 Aug; 8(4): 311-6. PMID: 8547773, ISSN: 0895-0385.

Karpos PA, Jones CK, McNamara MJ, Spengler DM. Persistent leakage of cerebrospinal fluid after intrathecal administration of morphine in an operation on the lumbar spine. A report of two cases. J Bone Joint Surg Am. 1994 Jun; 76(6): 916-8. PMID: 8200901, ISSN: 0021-9355.

Zhu M, Keller TS, Moeljanto E, Spengler DM. Multiplanar variations in the structural characteristics of cancellous bone. Bone. 1994 May; 15(3): 251-9. PMID: 8068445, ISSN: 8756-3282.

Zhu M, Keller TS, Spengler DM. Effects of specimen load-bearing and free surface layers on the compressive mechanical properties of cellular materials. J Biomech. 1994 Jan; 27(1): 57-66. PMID: 8106536, PII: 0021-9290(94)90032-9, ISSN: 0021-9290.

Gurwitz GS, Dawson JM, McNamara MJ, Federspiel CF, Spengler DM. Biomechanical analysis of three surgical approaches for lumbar burst fractures using short-segment instrumentation. Spine. 1993 Jun 6/15/1993; 18(8): 977-82. PMID: 8367785, ISSN: 0362-2436.

Stephens GC, Devito DP, McNamara MJ, Spengler DM. Short segment transpedicular Cotrel-Dubousset instrumentation: a porcine corpectomy model. J Spinal Disord. 1993 Jun; 6(3): 252-5. PMID: 8347977, ISSN: 0895-0385.

McNamara MJ, Barrett KG, Christie MJ, Spengler DM. Lumbar spinal stenosis and lower extremity arthroplasty. J Arthroplasty. 1993 Jun; 8(3): 273-7. PMID: 8326308, ISSN: 0883-5403.

McNamara MJ, Stephens GC, Spengler DM. Transpedicular short-segment fusions for treatment of lumbar burst fractures. J Spinal Disord. 1992 Jun; 5(2): 183-7. PMID: 1606376, ISSN: 0895-0385.

Keller TS, Moeljanto E, Main JA, Spengler DM. Distribution and orientation of bone in the human lumbar vertebral centrum. J Spinal Disord. 1992 Mar; 5(1): 60-74. PMID: 1571616, ISSN: 0895-0385.

McNamara MJ, Devito DP, Spengler DM. Circumferential fusion for the management of acute cervical spine trauma. J Spinal Disord. 1991 Dec; 4(4): 467-71. PMID: 1810571, ISSN: 0895-0385.

Green DA, Green NE, Spengler DM, Devito DP. Flexion-distraction injuries to the lumbar spine associated with abdominal injuries. J Spinal Disord. 1991 Sep; 4(3): 312-8. PMID: 1802162, ISSN: 0895-0385.

Spengler DM, Szpalski M. Newer assessment approaches for the patient with low back pain. Contemp Orthop. 1990 Oct; 21(4): 371-8. PMID: 10148054, ISSN: 0194-8458.

Keller TS, Holm SH, Hansson TH, Spengler DM. 1990 Volvo Award in experimental studies. The dependence of intervertebral disc mechanical properties on physiologic conditions. Spine. 1990 Aug; 15(8): 751-61. PMID: 2237625, ISSN: 0362-2436.

Keller TS, Mao Z, Spengler DM. Young's modulus, bending strength, and tissue physical properties of human compact bone. J. Orthop. Res. 1990 Jul; 8(4): 592-603. PMID: 2355299, DOI: 10.1002/jor.1100080416, ISSN: 0736-0266.

Pratt ES, Green DA, Spengler DM. Herniated intervertebral discs associated with unstable spinal injuries. Spine. 1990 Jul; 15(7): 662-6. PMID: 2218712, ISSN: 0362-2436.

1990; Available from: .

Abram AC, Keller TS, Spengler DM. The effects of simulated weightlessness on bone biomechanical and biochemical properties in the maturing rat. J Biomech. 1988; 21(9): 755-67. PMID: 3182879, ISSN: 0021-9290.

Fellmeth BD, DaSilva RM, Spengler DM. Hematogenous osteomyelitis complicating a closed compression fracture of the spine. J Spinal Disord. 1988; 1(2): 168-71. PMID: 2980074, ISSN: 0895-0385.

Phillips DL, Brick GW, Spengler DM. A comparison of Harrington rod fixation with and without segmental wires for unstable thoracolumbar injuries. J Spinal Disord. 1988; 1(2): 151-61. PMID: 2980072, ISSN: 0895-0385.