Roger J. Colbran, Ph.D.

Professor

roger.colbran@vanderbilt.edu

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Faculty Appointments
Professor of Molecular Physiology and Biophysics
Education
Ph.D., Biochemistry, University of Newcastle, NewcastleB.Sc., Biochemistry, University of Bristol, Bristol
Office Address
702 Light Hall
Nashville, TN 0615
Research Description
Many hormones and neurotransmitters act on cell surface receptors to elevate cytosolic levels of soluble second messengers such as cyclic AMP and calcium. These molecules diffuse freely but the dynamics of second messenger generation and removal are such that their concentrations are only elevated locally and transiently. This spatial heterogeneity implies that cellular proteins that are sensitive to second messengers have discrete subcellular localization(s). The overall goal of this laboratory is to understand how localization of signal transduction molecules is achieved and how this impacts cellular regulation.

Multiple synaptic roles for calcium/calmodulin-dependent protein kinase II (CaMKII)

Neurons are highly asymmetric cells due to their extensive dendritic and axonal processes. Moreover, the dendrites are covered with thousands of dendritic spines that receive synaptic inputs from many different neurons. Each synapse can be independently modulated on time scales ranging from milliseconds to the lifetime of the animal. Of particular interest are long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus, opposing forms of synaptic plasticity that are induced by calcium influx via NMDA-type glutamate receptors. High frequency stimulation of a synapse generally results in induction of LTP, where as low frequency stimulation induces LTD. Thus, calcium-dependent signaling molecules are able to generate different physiological responses depending on the frequency with which a synapse is stimulated. Furthermore, LTP and LTD are confined to synapse(s) that received the initial high or low frequency stimulation, respectively, without any ?spill-over? to nearby unstimulated synapses. The major focus of this laboratory is to determine the molecular mechanisms that permit synapse specific generation of LTP or LTD. Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a pivotal role in synaptic plasticity, learning and memory.

CaMKII as an integrator of diverse calcium signals

Dodecameric CaMKII holoenzymes require calcium and calmodulin for initial activation. Autophosphorylation at Thr286 converts the kinase to a form that has calcium/calmodulin-independent kinase activity, requiring a protein phosphatase to be inactivated. The activity of PP1¿¿1 targeted to the neuronal postsynaptic density by spinophilin and/or neurabin is believed to play a critical role in gating CaMKII autophosphorylation during synaptic plasticity. Thus, the opposing actions of calcium/calmodulin and protein phosphatases allow CaMKII to integrate information conveyed by the frequency, amplitude and duration of transient elevations of calcium that occur at synapses and induce LTP or LTD. In addition, it is very well established that Thr286 autophosphorylation is essential to normal synaptic plasticity, learning and memory.

Mechanisms of CaMKII Targeting

Our central hypothesis is that specific synaptic actions of CaMKII require the assembly of specific multiprotein complexes containing CaMKII and downstream mediators of individual signaling pathways, and are opposed by specific PP1 complexes. We are investigating several synaptic proteins that dynamically interact with CaMKII or PP1 by distinct biochemical mechanisms, including subunits of NMDA-type glutamate receptors and voltage-gated calcium channels, densin-180, alpha-actinin, spinophilin and neurabin, as well as some novel interactions. Of particular note, we recently showed that CaMKII binds to and phosphorylates diacylglycerol lipase-alpha, the enzyme responsible for synthesis of the most abundant brain endocannabinoid, 2-arachidonylglycerol, to modulate glutamatergic synapses in the striatum and motor function. Our goal is to understand the biochemical/structural basis for these interactions and use this information to help us identify specific roles for these interactions in controlling synaptic function both physiologically (e.g., LTP/LTD) and
Research Keywords
Structure, function and subcellular targeting of Ca2+/calmodulin-dependent protein kinase II in health and disease
Publications
Frederick AL, Yano H, Trifilieff P, Vishwasrao HD, Biezonski D, Mészáros J, Urizar E, Sibley DR, Kellendonk C, Sonntag KC, Graham DL, Colbran RJ, Stanwood GD, Javitch JA. Evidence against dopamine D1/D2 receptor heteromers. Mol. Psychiatry [print-electronic]. 2015 Nov; 20(11): 1373-85. PMID: 25560761, PMCID: PMC4492915, PII: mp2014166, DOI: 10.1038/mp.2014.166, ISSN: 1476-5578.

Baucum AJ, Shonesy BC, Rose KL, Colbran RJ. Quantitative proteomics analysis of CaMKII phosphorylation and the CaMKII interactome in the mouse forebrain. ACS Chem Neurosci [print-electronic]. 2015 Apr 4/15/2015; 6(4): 615-31. PMID: 25650780, PMCID: PMC4609176, DOI: 10.1021/cn500337u, ISSN: 1948-7193.

Shonesy BC, Winder DG, Patel S, Colbran RJ. The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium. Neuropharmacology [print-electronic]. 2015 Apr; 91: 57-62. PMID: 25484252, PMCID: PMC4312705, PII: S0028-3908(14)00442-0, DOI: 10.1016/j.neuropharm.2014.11.026, ISSN: 1873-7064.

Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels. Nat. Cell Biol. 2015 Apr; 17(4): 530. PMID: 25812523, PII: ncb3151, DOI: 10.1038/ncb3151, ISSN: 1476-4679.

Shonesy BC, Bluett RJ, Ramikie TS, Báldi R, Hermanson DJ, Kingsley PJ, Marnett LJ, Winder DG, Colbran RJ, Patel S. Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation. Cell Rep [print-electronic]. 2014 Dec 12/11/2014; 9(5): 1644-53. PMID: 25466252, PMCID: PMC4268380, PII: S2211-1247(14)00955-3, DOI: 10.1016/j.celrep.2014.11.001, ISSN: 2211-1247.

Dadi PK, Vierra NC, Ustione A, Piston DW, Colbran RJ, Jacobson DA. Inhibition of pancreatic ß-cell Ca2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance. J. Biol. Chem [print-electronic]. 2014 May 5/2/2014; 289(18): 12435-45. PMID: 24627477, PMCID: PMC4007438, PII: M114.562587, DOI: 10.1074/jbc.M114.562587, ISSN: 1083-351X.

Shonesy BC, Jalan-Sakrikar N, Cavener VS, Colbran RJ. CaMKII: a molecular substrate for synaptic plasticity and memory. Prog Mol Biol Transl Sci. 2014; 122: 61-87. PMID: 24484698, PII: B978-0-12-420170-5.00003-9, DOI: 10.1016/B978-0-12-420170-5.00003-9, ISSN: 1878-0814.

McCoy F, Darbandi R, Lee HC, Bharatham K, Moldoveanu T, Grace CR, Dodd K, Lin W, Chen SI, Tangallapally RP, Kurokawa M, Lee RE, Shelat AA, Chen T, Green DR, Harris RA, Lin SH, Fissore RA, Colbran RJ, Nutt LK. Metabolic activation of CaMKII by coenzyme A. Mol. Cell [print-electronic]. 2013 Nov 11/7/2013; 52(3): 325-39. PMID: 24095281, PMCID: PMC3967247, PII: S1097-2765(13)00643-6, DOI: 10.1016/j.molcel.2013.08.043, ISSN: 1097-4164.

Deutch AY, Hedera P, Colbran RJ. REEPing the benefits of an animal model of hereditary spastic paraplegia. J. Clin. Invest [print-electronic]. 2013 Oct; 123(10): 4134-6. PMID: 24051371, PMCID: PMC3784552, PII: 72324, DOI: 10.1172/JCI72324, ISSN: 1558-8238.

Hermanson DJ, Hartley ND, Gamble-George J, Brown N, Shonesy BC, Kingsley PJ, Colbran RJ, Reese J, Marnett LJ, Patel S. Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation. Nat. Neurosci [print-electronic]. 2013 Sep; 16(9): 1291-8. PMID: 23912944, PMCID: PMC3788575, PII: nn.3480, DOI: 10.1038/nn.3480, ISSN: 1546-1726.

Shonesy BC, Wang X, Rose KL, Ramikie TS, Cavener VS, Rentz T, Baucum AJ, Jalan-Sakrikar N, Mackie K, Winder DG, Patel S, Colbran RJ. CaMKII regulates diacylglycerol lipase-a and striatal endocannabinoid signaling. Nat. Neurosci [print-electronic]. 2013 Apr; 16(4): 456-63. PMID: 23502535, PMCID: PMC3636998, PII: nn.3353, DOI: 10.1038/nn.3353, ISSN: 1546-1726.

McCoy F, Darbandi R, Chen SI, Eckard L, Dodd K, Jones K, Baucum AJ, Gibbons JA, Lin SH, Colbran RJ, Nutt LK. Metabolic regulation of CaMKII protein and caspases in Xenopus laevis egg extracts. J. Biol. Chem [print-electronic]. 2013 Mar 3/29/2013; 288(13): 8838-48. PMID: 23400775, PMCID: PMC3610959, PII: M112.437186, DOI: 10.1074/jbc.M112.437186, ISSN: 1083-351X.

Baucum AJ, Brown AM, Colbran RJ. Differential association of postsynaptic signaling protein complexes in striatum and hippocampus. J. Neurochem [print-electronic]. 2013 Feb; 124(4): 490-501. PMID: 23173822, PMCID: PMC3557548, DOI: 10.1111/jnc.12101, ISSN: 1471-4159.

Jalan-Sakrikar N, Bartlett RK, Baucum AJ, Colbran RJ. Substrate-selective and calcium-independent activation of CaMKII by a-actinin. J. Biol. Chem [print-electronic]. 2012 May 5/4/2012; 287(19): 15275-83. PMID: 22427672, PMCID: PMC3346149, PII: M112.351817, DOI: 10.1074/jbc.M112.351817, ISSN: 1083-351X.

Wills TA, Klug JR, Silberman Y, Baucum AJ, Weitlauf C, Colbran RJ, Delpire E, Winder DG. GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2012 Jan 1/31/2012; 109(5): E278-87. PMID: 22219357, PMCID: PMC3277158, PII: 1113820109, DOI: 10.1073/pnas.1113820109, ISSN: 1091-6490.

Klug JR, Mathur BN, Kash TL, Wang HD, Matthews RT, Robison AJ, Anderson ME, Deutch AY, Lovinger DM, Colbran RJ, Winder DG. Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability. PLoS ONE [print-electronic]. 2012; 7(9): e45323. PMID: 23028932, PMCID: PMC3448631, PII: PONE-D-12-17469, DOI: 10.1371/journal.pone.0045323, ISSN: 1932-6203.

Baucum AJ, Strack S, Colbran RJ. Age-dependent targeting of protein phosphatase 1 to Ca2+/calmodulin-dependent protein kinase II by spinophilin in mouse striatum. PLoS ONE [print-electronic]. 2012; 7(2): e31554. PMID: 22348105, PMCID: PMC3278457, PII: PONE-D-11-14643, DOI: 10.1371/journal.pone.0031554, ISSN: 1932-6203.

Gustin RM, Shonesy BC, Robinson SL, Rentz TJ, Baucum AJ, Jalan-Sakrikar N, Winder DG, Stanwood GD, Colbran RJ. Loss of Thr286 phosphorylation disrupts synaptic CaMKIIa targeting, NMDAR activity and behavior in pre-adolescent mice. Mol. Cell. Neurosci [print-electronic]. 2011 Aug; 47(4): 286-92. PMID: 21627991, PMCID: PMC3149813, PII: S1044-7431(11)00112-6, DOI: 10.1016/j.mcn.2011.05.006, ISSN: 1095-9327.

Jiao Y, Jalan-Sakrikar N, Robison AJ, Baucum AJ, Bass MA, Colbran RJ. Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation. J. Biol. Chem [print-electronic]. 2011 Jul 7/15/2011; 286(28): 24806-18. PMID: 21610080, PMCID: PMC3137056, PII: M110.216010, DOI: 10.1074/jbc.M110.216010, ISSN: 1083-351X.

Hoffman L, Stein RA, Colbran RJ, Mchaourab HS. Conformational changes underlying calcium/calmodulin-dependent protein kinase II activation. EMBO J [print-electronic]. 2011 Apr 4/6/2011; 30(7): 1251-62. PMID: 21343908, PMCID: PMC3094114, PII: emboj201140, DOI: 10.1038/emboj.2011.40, ISSN: 1460-2075.

Gustin RM, Bichell TJ, Bubser M, Daily J, Filonova I, Mrelashvili D, Deutch AY, Colbran RJ, Weeber EJ, Haas KF. Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome. Neurobiol. Dis [print-electronic]. 2010 Sep; 39(3): 283-91. PMID: 20423730, PMCID: PMC2922926, PII: S0969-9961(10)00128-2, DOI: 10.1016/j.nbd.2010.04.012, ISSN: 1095-953X.

Baucum AJ, Jalan-Sakrikar N, Jiao Y, Gustin RM, Carmody LC, Tabb DL, Ham AJ, Colbran RJ. Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach. Mol. Cell Proteomics [print-electronic]. 2010 Jun; 9(6): 1243-59. PMID: 20124353, PMCID: PMC2877984, PII: M900387-MCP200, DOI: 10.1074/mcp.M900387-MCP200, ISSN: 1535-9484.

Bowton E, Saunders C, Erreger K, Sakrikar D, Matthies HJ, Sen N, Jessen T, Colbran RJ, Caron MG, Javitch JA, Blakely RD, Galli A. Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder. J. Neurosci. 2010 Apr 4/28/2010; 30(17): 6048-57. PMID: 20427663, PMCID: PMC2881830, PII: 30/17/6048, DOI: 10.1523/JNEUROSCI.5094-09.2010, ISSN: 1529-2401.

Jenkins MA, Christel CJ, Jiao Y, Abiria S, Kim KY, Usachev YM, Obermair GJ, Colbran RJ, Lee A. Ca2+-dependent facilitation of Cav1.3 Ca2+ channels by densin and Ca2+/calmodulin-dependent protein kinase II. J. Neurosci. 2010 Apr 4/14/2010; 30(15): 5125-35. PMID: 20392935, PMCID: PMC2990970, PII: 30/15/5125, DOI: 10.1523/JNEUROSCI.4367-09.2010, ISSN: 1529-2401.

Brigman JL, Wright T, Talani G, Prasad-Mulcare S, Jinde S, Seabold GK, Mathur P, Davis MI, Bock R, Gustin RM, Colbran RJ, Alvarez VA, Nakazawa K, Delpire E, Lovinger DM, Holmes A. Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. J. Neurosci. 2010 Mar 3/31/2010; 30(13): 4590-600. PMID: 20357110, PMCID: PMC2869199, PII: 30/13/4590, DOI: 10.1523/JNEUROSCI.0640-10.2010, ISSN: 1529-2401.

Koval OM, Guan X, Wu Y, Joiner ML, Gao Z, Chen B, Grumbach IM, Luczak ED, Colbran RJ, Song LS, Hund TJ, Mohler PJ, Anderson ME. CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2010 Mar 3/16/2010; 107(11): 4996-5000. PMID: 20194790, PMCID: PMC2841943, PII: 0913760107, DOI: 10.1073/pnas.0913760107, ISSN: 1091-6490.

Nikandrova YA, Jiao Y, Baucum AJ, Tavalin SJ, Colbran RJ. Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activity. J. Biol. Chem [print-electronic]. 2010 Jan 1/8/2010; 285(2): 923-34. PMID: 19858198, PMCID: PMC2801293, PII: M109.033985, DOI: 10.1074/jbc.M109.033985, ISSN: 1083-351X.

Abiria SA, Colbran RJ. CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation. J. Neurochem [print-electronic]. 2010 Jan; 112(1): 150-61. PMID: 19840220, PMCID: PMC2814318, PII: JNC6436, DOI: 10.1111/j.1471-4159.2009.06436.x, ISSN: 1471-4159.

Kash TL, Baucum AJ, Conrad KL, Colbran RJ, Winder DG. Alcohol exposure alters NMDAR function in the bed nucleus of the stria terminalis. Neuropsychopharmacology [print-electronic]. 2009 Oct; 34(11): 2420-9. PMID: 19553918, PMCID: PMC2864644, PII: npp200969, DOI: 10.1038/npp.2009.69, ISSN: 1740-634X.

Neely MD, Robert EM, Baucum AJ, Colbran RJ, Muly EC, Deutch AY. Localization of myocyte enhancer factor 2 in the rodent forebrain: regionally-specific cytoplasmic expression of MEF2A. Brain Res [print-electronic]. 2009 Jun 6/5/2009; 1274: 55-65. PMID: 19362076, PMCID: PMC2723059, PII: S0006-8993(09)00693-3, DOI: 10.1016/j.brainres.2009.03.067, ISSN: 1872-6240.

Binda F, Dipace C, Bowton E, Robertson SD, Lute BJ, Fog JU, Zhang M, Sen N, Colbran RJ, Gnegy ME, Gether U, Javitch JA, Erreger K, Galli A. Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. Mol. Pharmacol [print-electronic]. 2008 Oct; 74(4): 1101-8. PMID: 18617632, PMCID: PMC2728020, PII: mol.108.048447, DOI: 10.1124/mol.108.048447, ISSN: 1521-0111.

Jiao Y, Robison AJ, Bass MA, Colbran RJ. Developmentally regulated alternative splicing of densin modulates protein-protein interaction and subcellular localization. J. Neurochem [print-electronic]. 2008 Jun; 105(5): 1746-60. PMID: 18248607, PMCID: PMC2814316, PII: JNC5280, DOI: 10.1111/j.1471-4159.2008.05280.x, ISSN: 1471-4159.

Carmody LC, Baucum AJ, Bass MA, Colbran RJ. Selective targeting of the gamma1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin. FASEB J [print-electronic]. 2008 Jun; 22(6): 1660-71. PMID: 18216290, PMCID: PMC2814319, PII: fj.07-092841, DOI: 10.1096/fj.07-092841, ISSN: 1530-6860.

Brown AM, Baucum AJ, Bass MA, Colbran RJ. Association of protein phosphatase 1 gamma 1 with spinophilin suppresses phosphatase activity in a Parkinson disease model. J. Biol. Chem [print-electronic]. 2008 May 5/23/2008; 283(21): 14286-94. PMID: 18372251, PMCID: PMC2386916, PII: M801377200, DOI: 10.1074/jbc.M801377200, ISSN: 0021-9258.

Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, O'Donnell SE, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham AJ, Weiss RM, Spitz DR, Shea MA, Colbran RJ, Mohler PJ, Anderson ME. A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell. 2008 May 5/2/2008; 133(3): 462-74. PMID: 18455987, PMCID: PMC2435269, PII: S0092-8674(08)00398-X, DOI: 10.1016/j.cell.2008.02.048, ISSN: 1097-4172.

Grueter CE, Abiria SA, Wu Y, Anderson ME, Colbran RJ. Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits. Biochemistry [print-electronic]. 2008 Feb 2/12/2008; 47(6): 1760-7. PMID: 18205403, PMCID: PMC2814322, DOI: 10.1021/bi701755q, ISSN: 0006-2960.

Khoo MS, Grueter CE, Eren M, Yang J, Zhang R, Bass MA, Lwin ST, Mendes LA, Vaughan DE, Colbran RJ, Anderson ME. Calmodulin kinase II inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein. J. Mol. Cell. Cardiol [print-electronic]. 2008 Feb; 44(2): 405-10. PMID: 18048055, PMCID: PMC2695824, PII: S0022-2828(07)01280-1, DOI: 10.1016/j.yjmcc.2007.10.014, ISSN: 1095-8584.

Colbran, RJ. In J. David Sweatt (Ed.), Molecular Mechanisms of Memory. Vol. [4] of Learning and Memory: A Comprehensive Reference, 4 vols. (J.Byrne Editor). [place unknown: publisher unknown]; 2008.

Robison AJ, Winder DG, Colbran RJ, Bartlett RK. Oxidation of calmodulin alters activation and regulation of CaMKII. Biochem. Biophys. Res. Commun [print-electronic]. 2007 Apr 4/27/2007; 356(1): 97-101. PMID: 17343827, PMCID: PMC1899527, PII: S0006-291X(07)00381-6, DOI: 10.1016/j.bbrc.2007.02.087, ISSN: 0006-291X.

Grueter CE, Colbran RJ, Anderson ME. CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction. J. Mol. Med [print-electronic]. 2007 Jan; 85(1): 5-14. PMID: 17119905, DOI: 10.1007/s00109-006-0125-6, ISSN: 0946-2716.

Deutch AY, Colbran RJ, Winder DJ. Striatal plasticity and medium spiny neuron dendritic remodeling in parkinsonism. Parkinsonism Relat. Disord. 2007; 13 Suppl 3: S251-8. PMID: 18267246, PII: S1353-8020(08)70012-9, DOI: 10.1016/S1353-8020(08)70012-9, ISSN: 1353-8020.

Khoo MS, Li J, Singh MV, Yang Y, Kannankeril P, Wu Y, Grueter CE, Guan X, Oddis CV, Zhang R, Mendes L, Ni G, Madu EC, Yang J, Bass M, Gomez RJ, Wadzinski BE, Olson EN, Colbran RJ, Anderson ME. Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy. Circulation [print-electronic]. 2006 Sep 9/26/2006; 114(13): 1352-9. PMID: 16982937, PII: CIRCULATIONAHA.106.644583, DOI: 10.1161/CIRCULATIONAHA.106.644583, ISSN: 1524-4539.

Grueter CE, Abiria SA, Dzhura I, Wu Y, Ham AJ, Mohler PJ, Anderson ME, Colbran RJ. L-type Ca2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKII. Mol. Cell. 2006 Sep 9/1/2006; 23(5): 641-50. PMID: 16949361, PII: S1097-2765(06)00483-7, DOI: 10.1016/j.molcel.2006.07.006, ISSN: 1097-2765.

Yao J, Davies LA, Howard JD, Adney SK, Welsby PJ, Howell N, Carey RM, Colbran RJ, Barrett PQ. Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+/calmodulin-dependent protein kinase II. J. Clin. Invest [print-electronic]. 2006 Sep; 116(9): 2403-12. PMID: 16917542, PMCID: PMC1550277, DOI: 10.1172/JCI27918, ISSN: 0021-9738.

Fog JU, Khoshbouei H, Holy M, Owens WA, Vaegter CB, Sen N, Nikandrova Y, Bowton E, McMahon DG, Colbran RJ, Daws LC, Sitte HH, Javitch JA, Galli A, Gether U. Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport. Neuron. 2006 Aug 8/17/2006; 51(4): 417-29. PMID: 16908408, PII: S0896-6273(06)00508-3, DOI: 10.1016/j.neuron.2006.06.028, ISSN: 0896-6273.

Wu Y, Shintani A, Grueter C, Zhang R, Hou Y, Yang J, Kranias EG, Colbran RJ, Anderson ME. Suppression of dynamic Ca(2+) transient responses to pacing in ventricular myocytes from mice with genetic calmodulin kinase II inhibition. J. Mol. Cell. Cardiol [print-electronic]. 2006 Feb; 40(2): 213-23. PMID: 16413575, PII: S0022-2828(05)00343-3, DOI: 10.1016/j.yjmcc.2005.11.005, ISSN: 0022-2828.

Bordelon JR, Smith Y, Nairn AC, Colbran RJ, Greengard P, Muly EC. Differential localization of protein phosphatase-1alpha, beta and gamma1 isoforms in primate prefrontal cortex. Cereb. Cortex [print-electronic]. 2005 Dec; 15(12): 1928-37. PMID: 15758197, PMCID: PMC2586106, PII: bhi070, DOI: 10.1093/cercor/bhi070, ISSN: 1047-3211.

Robison AJ, Bartlett RK, Bass MA, Colbran RJ. Differential modulation of Ca2+/calmodulin-dependent protein kinase II activity by regulated interactions with N-methyl-D-aspartate receptor NR2B subunits and alpha-actinin. J. Biol. Chem [print-electronic]. 2005 Nov 11/25/2005; 280(47): 39316-23. PMID: 16172120, PII: M508189200, DOI: 10.1074/jbc.M508189200, ISSN: 0021-9258.

Robison AJ, Bass MA, Jiao Y, MacMillan LB, Carmody LC, Bartlett RK, Colbran RJ. Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. J. Biol. Chem [print-electronic]. 2005 Oct 10/21/2005; 280(42): 35329-36. PMID: 16120608, PII: M502191200, DOI: 10.1074/jbc.M502191200, ISSN: 0021-9258.

Zhang R, Dzhura I, Grueter CE, Thiel W, Colbran RJ, Anderson ME. A dynamic alpha-beta inter-subunit agonist signaling complex is a novel feedback mechanism for regulating L-type Ca2+ channel opening. FASEB J [print-electronic]. 2005 Sep; 19(11): 1573-5. PMID: 15994413, PII: 04-3283fje, DOI: 10.1096/fj.04-3283fje, ISSN: 1530-6860.

Brown AM, Deutch AY, Colbran RJ. Dopamine depletion alters phosphorylation of striatal proteins in a model of Parkinsonism. Eur. J. Neurosci. 2005 Jul; 22(1): 247-56. PMID: 16029214, PII: EJN4190, DOI: 10.1111/j.1460-9568.2005.04190.x, ISSN: 0953-816X.

Khoo MS, Kannankeril PJ, Li J, Zhang R, Kupershmidt S, Zhang W, Atkinson JB, Colbran RJ, Roden DM, Anderson ME. Calmodulin kinase II activity is required for normal atrioventricular nodal conduction. Heart Rhythm. 2005 Jun; 2(6): 634-40. PMID: 15922273, PII: S1547-5271(05)01441-4, DOI: 10.1016/j.hrthm.2005.03.019, ISSN: 1547-5271.

Sessoms-Sikes S, Honse Y, Lovinger DM, Colbran RJ. CaMKIIalpha enhances the desensitization of NR2B-containing NMDA receptors by an autophosphorylation-dependent mechanism. Mol. Cell. Neurosci. 2005 May; 29(1): 139-47. PMID: 15866054, PII: S1044-7431(05)00013-8, DOI: 10.1016/j.mcn.2005.01.006, ISSN: 1044-7431.

Zhang R, Khoo MS, Wu Y, Yang Y, Grueter CE, Ni G, Price EE, Thiel W, Guatimosim S, Song LS, Madu EC, Shah AN, Vishnivetskaya TA, Atkinson JB, Gurevich VV, Salama G, Lederer WJ, Colbran RJ, Anderson ME. Calmodulin kinase II inhibition protects against structural heart disease. Nat. Med [print-electronic]. 2005 Apr; 11(4): 409-17. PMID: 15793582, PII: nm1215, DOI: 10.1038/nm1215, ISSN: 1078-8956.

Norman ED, Egli RE, Colbran RJ, Winder DG. A potassium channel blocker induces a long-lasting enhancement of corticostriatal responses. Neuropharmacology. 2005 Feb; 48(2): 311-21. PMID: 15695170, PII: S0028-3908(04)00348-X, DOI: 10.1016/j.neuropharm.2004.09.018, ISSN: 0028-3908.

Colbran RJ. Protein phosphatases and calcium/calmodulin-dependent protein kinase II-dependent synaptic plasticity. J. Neurosci. 2004 Sep 9/29/2004; 24(39): 8404-9. PMID: 15456812, PII: 24/39/8404, DOI: 10.1523/JNEUROSCI.3602-04.2004, ISSN: 1529-2401.

Colbran RJ, Brown AM. Calcium/calmodulin-dependent protein kinase II and synaptic plasticity. Curr. Opin. Neurobiol. 2004 Jun; 14(3): 318-27. PMID: 15194112, PII: S0959438804000753, DOI: 10.1016/j.conb.2004.05.008, ISSN: 0959-4388.

Carmody LC, Bauman PA, Bass MA, Mavila N, DePaoli-Roach AA, Colbran RJ. A protein phosphatase-1gamma1 isoform selectivity determinant in dendritic spine-associated neurabin. J. Biol. Chem [print-electronic]. 2004 May 5/21/2004; 279(21): 21714-23. PMID: 15016827, PII: M402261200, DOI: 10.1074/jbc.M402261200, ISSN: 0021-9258.

Colbran RJ. Targeting of calcium/calmodulin-dependent protein kinase II. Biochem. J. 2004 Feb 2/15/2004; 378(Pt 1): 1-16. PMID: 14653781, PMCID: PMC1223945, PII: BJ20031547, DOI: 10.1042/BJ20031547, ISSN: 1470-8728.

Wu Y, Kimbrough JT, Colbran RJ, Anderson ME. Calmodulin kinase is functionally targeted to the action potential plateau for regulation of L-type Ca2+ current in rabbit cardiomyocytes. J. Physiol. (Lond.). 2004 Jan 1/1/2004; 554(Pt 1): 145-55. PMID: 14678498, PMCID: PMC1664743, PII: jphysiol.2003.053314, DOI: 10.1113/jphysiol.2003.053314, ISSN: 0022-3751.

Robison, AJ, Colbran, RJ. In: "Encyclopedia of Biological Chemistry" (Lennarz, W.J and Lane, M.D., eds.). Elsevier, Oxford. [place unknown: publisher unknown]; 2004. (1).

Welsby PJ, Wang H, Wolfe JT, Colbran RJ, Johnson ML, Barrett PQ. A mechanism for the direct regulation of T-type calcium channels by Ca2+/calmodulin-dependent kinase II. J. Neurosci. 2003 Nov 11/5/2003; 23(31): 10116-21. PMID: 14602827, PII: 23/31/10116, ISSN: 1529-2401.

Kloeker S, Reed R, McConnell JL, Chang D, Tran K, Westphal RS, Law BK, Colbran RJ, Kamoun M, Campbell KS, Wadzinski BE. Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein. Protein Expr. Purif. 2003 Sep; 31(1): 19-33. PMID: 12963337, PII: S1046592803001414, ISSN: 1046-5928.

Brady AE, Wang Q, Colbran RJ, Allen PB, Greengard P, Limbird LE. Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors. J. Biol. Chem [print-electronic]. 2003 Aug 8/22/2003; 278(34): 32405-12. PMID: 12738775, PII: M304195200, DOI: 10.1074/jbc.M304195200, ISSN: 0021-9258.

Dzhura I, Wu Y, Zhang R, Colbran RJ, Hamilton SL, Anderson ME. C terminus L-type Ca2+ channel calmodulin-binding domains are 'auto-agonist' ligands in rabbit ventricular myocytes. J. Physiol. (Lond.) [print-electronic]. 2003 Aug 8/1/2003; 550(Pt 3): 731-8. PMID: 12807986, PMCID: PMC2343075, PII: 2003.043778, DOI: 10.1113/jphysiol.2003.043778, ISSN: 0022-3751.

Colbran RJ, Carmody LC, Bauman PA, Wadzinski BE, Bass MA. Analysis of specific interactions of native protein phosphatase 1 isoforms with targeting subunits. Meth. Enzymol. 2003; 366: 156-75. PMID: 14674248, ISSN: 0076-6879.

Dzhura I, Wu Y, Colbran RJ, Corbin JD, Balser JR, Anderson ME. Cytoskeletal disrupting agents prevent calmodulin kinase, IQ domain and voltage-dependent facilitation of L-type Ca2+ channels. J. Physiol. (Lond.). 2002 Dec 12/1/2002; 545(Pt 2): 399-406. PMID: 12456820, PMCID: PMC2290681, PII: PHY_021881, ISSN: 0022-3751.

Wu Y, Temple J, Zhang R, Dzhura I, Zhang W, Trimble R, Roden DM, Passier R, Olson EN, Colbran RJ, Anderson ME. Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy. Circulation. 2002 Sep 9/3/2002; 106(10): 1288-93. PMID: 12208807, ISSN: 1524-4539.

Terry-Lorenzo RT, Carmody LC, Voltz JW, Connor JH, Li S, Smith FD, Milgram SL, Colbran RJ, Shenolikar S. The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. J. Biol. Chem [print-electronic]. 2002 Aug 8/2/2002; 277(31): 27716-24. PMID: 12016225, PII: M203365200, DOI: 10.1074/jbc.M203365200, ISSN: 0021-9258.

Oliver CJ, Terry-Lorenzo RT, Elliott E, Bloomer WA, Li S, Brautigan DL, Colbran RJ, Shenolikar S. Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. Mol. Cell. Biol. 2002 Jul; 22(13): 4690-701. PMID: 12052877, PMCID: PMC133892, ISSN: 0270-7306.

Wu Y, Dzhura I, Colbran RJ, Anderson ME. Calmodulin kinase and a calmodulin-binding 'IQ' domain facilitate L-type Ca2+ current in rabbit ventricular myocytes by a common mechanism. J. Physiol. (Lond.). 2001 Sep 9/15/2001; 535(Pt 3): 679-87. PMID: 11559766, PMCID: PMC2278813, PII: PHY_12560, ISSN: 0022-3751.

Richman JG, Brady AE, Wang Q, Hensel JL, Colbran RJ, Limbird LE. Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin. J. Biol. Chem [print-electronic]. 2001 May 5/4/2001; 276(18): 15003-8. PMID: 11154706, PII: M011679200, DOI: 10.1074/jbc.M011679200, ISSN: 0021-9258.

Chen HX, Otmakhov N, Strack S, Colbran RJ, Lisman JE. Is persistent activity of calcium/calmodulin-dependent kinase required for the maintenance of LTP?. J. Neurophysiol. 2001 Apr; 85(4): 1368-76. PMID: 11287461, ISSN: 0022-3077.

Wu Y, Colbran RJ, Anderson ME. Calmodulin kinase is a molecular switch for cardiac excitation-contraction coupling. Proc. Natl. Acad. Sci. U.S.A. 2001 Feb 2/27/2001; 98(5): 2877-81. PMID: 11226334, PMCID: PMC30233, PII: 98/5/2877, DOI: 10.1073/pnas.051449198, ISSN: 0027-8424.

Barrett PQ, Lu HK, Colbran R, Czernik A, Pancrazio JJ. Stimulation of unitary T-type Ca(2+) channel currents by calmodulin-dependent protein kinase II. Am. J. Physiol., Cell Physiol. 2000 Dec; 279(6): C1694-703. PMID: 11078683, ISSN: 0363-6143.

Strack S, Robison AJ, Bass MA, Colbran RJ. Association of calcium/calmodulin-dependent kinase II with developmentally regulated splice variants of the postsynaptic density protein densin-180. J. Biol. Chem. 2000 Aug 8/18/2000; 275(33): 25061-4. PMID: 10827168, PII: C000319200, DOI: 10.1074/jbc.C000319200, ISSN: 0021-9258.

Strack S, McNeill RB, Colbran RJ. Mechanism and regulation of calcium/calmodulin-dependent protein kinase II targeting to the NR2B subunit of the N-methyl-D-aspartate receptor. J. Biol. Chem. 2000 Aug 8/4/2000; 275(31): 23798-806. PMID: 10764765, PII: M001471200, DOI: 10.1074/jbc.M001471200, ISSN: 0021-9258.

Zhao L, Cissell MA, Henderson E, Colbran R, Stein R. The RIPE3b1 activator of the insulin gene is composed of a protein(s) of approximately 43 kDa, whose DNA binding activity is inhibited by protein phosphatase treatment. J. Biol. Chem. 2000 Apr 4/7/2000; 275(14): 10532-7. PMID: 10744746, ISSN: 0021-9258.

Dzhura I, Wu Y, Colbran RJ, Balser JR, Anderson ME. Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels. Nat. Cell Biol. 2000 Mar; 2(3): 173-7. PMID: 10707089, DOI: 10.1038/35004052, ISSN: 1465-7392.

Yang P, Fox L, Colbran RJ, Sale WS. Protein phosphatases PP1 and PP2A are located in distinct positions in the Chlamydomonas flagellar axoneme. J. Cell. Sci. 2000 Jan; 113 ( Pt 1): 91-102. PMID: 10591628, ISSN: 0021-9533.

MacMillan LB, Bass MA, Cheng N, Howard EF, Tamura M, Strack S, Wadzinski BE, Colbran RJ. Brain actin-associated protein phosphatase 1 holoenzymes containing spinophilin, neurabin, and selected catalytic subunit isoforms. J. Biol. Chem. 1999 Dec 12/10/1999; 274(50): 35845-54. PMID: 10585469, ISSN: 0021-9258.

Strack S, Chang D, Zaucha JA, Colbran RJ, Wadzinski BE. Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A. FEBS Lett. 1999 Nov 11/5/1999; 460(3): 462-6. PMID: 10556517, PII: S0014-5793(99)01377-0, ISSN: 0014-5793.

Strack S, Kini S, Ebner FF, Wadzinski BE, Colbran RJ. Differential cellular and subcellular localization of protein phosphatase 1 isoforms in brain. J. Comp. Neurol. 1999 Oct 10/25/1999; 413(3): 373-84. PMID: 10502246, PII: 10.1002/(SICI)1096-9861(19991025)413:3<373::AID-CNE2>3.0.CO;2-Z, ISSN: 0021-9967.

Wu Y, MacMillan LB, McNeill RB, Colbran RJ, Anderson ME. CaM kinase augments cardiac L-type Ca2+ current: a cellular mechanism for long Q-T arrhythmias. Am. J. Physiol. 1999 Jun; 276(6 Pt 2): H2168-78. PMID: 10362701, ISSN: 0002-9513.

Strack S, Colbran RJ. Autophosphorylation-dependent targeting of calcium/ calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl- D-aspartate receptor. J. Biol. Chem. 1998 Aug 8/14/1998; 273(33): 20689-92. PMID: 9694809, ISSN: 0021-9258.

Strack S, Zaucha JA, Ebner FF, Colbran RJ, Wadzinski BE. Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits. J. Comp. Neurol. 1998 Mar 3/23/1998; 392(4): 515-27. PMID: 9514514, PII: 10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3, ISSN: 0021-9967.

Kloeker S, Bryant JC, Strack S, Colbran RJ, Wadzinski BE. Carboxymethylation of nuclear protein serine/threonine phosphatase X. Biochem. J. 1997 Oct 10/15/1997; 327 ( Pt 2): 481-6. PMID: 9359419, PMCID: PMC1218819, ISSN: 0264-6021.

Strack S, Westphal RS, Colbran RJ, Ebner FF, Wadzinski BE. Protein serine/threonine phosphatase 1 and 2A associate with and dephosphorylate neurofilaments. Brain Res. Mol. Brain Res. 1997 Oct 10/3/1997; 49(1-2): 15-28. PMID: 9387859, ISSN: 0169-328X.

Colbran RJ, Bass MA, McNeill RB, Bollen M, Zhao S, Wadzinski BE, Strack S. Association of brain protein phosphatase 1 with cytoskeletal targeting/regulatory subunits. J. Neurochem. 1997 Sep; 69(3): 920-9. PMID: 9282913, ISSN: 0022-3042.

Strack S, Choi S, Lovinger DM, Colbran RJ. Translocation of autophosphorylated calcium/calmodulin-dependent protein kinase II to the postsynaptic density. J. Biol. Chem. 1997 May 5/23/1997; 272(21): 13467-70. PMID: 9153188, ISSN: 0021-9258.

Strack S, Barban MA, Wadzinski BE, Colbran RJ. Differential inactivation of postsynaptic density-associated and soluble Ca2+/calmodulin-dependent protein kinase II by protein phosphatases 1 and 2A. J. Neurochem. 1997 May; 68(5): 2119-28. PMID: 9109540, ISSN: 0022-3042.

McNeill RB, Colbran RJ. Interaction of autophosphorylated Ca2+/calmodulin-dependent protein kinase II with neuronal cytoskeletal proteins. Characterization of binding to a 190-kDa postsynaptic density protein. J. Biol. Chem. 1995 Apr 4/28/1995; 270(17): 10043-9. PMID: 7730306, ISSN: 0021-9258.

Colbran RJ. Inactivation of Ca2+/calmodulin-dependent protein kinase II by basal autophosphorylation. J. Biol. Chem. 1993 Apr 4/5/1993; 268(10): 7163-70. PMID: 8385100, ISSN: 0021-9258.

Colbran RJ. Regulation and role of brain calcium/calmodulin-dependent protein kinase II. Neurochem. Int. 1992 Dec; 21(4): 469-97. PMID: 1338943, ISSN: 0197-0186.

Smith MK, Colbran RJ, Brickey DA, Soderling TR. Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues. J. Biol. Chem. 1992 Jan 1/25/1992; 267(3): 1761-8. PMID: 1309796, ISSN: 0021-9258.

Soderling TR, Fukunaga K, Brickey DA, Fong YL, Rich DP, Smith K, Colbran RJ. Molecular and cellular studies on brain calcium/calmodulin-dependent protein kinase II. Prog. Brain Res. 1991; 89: 169-83. PMID: 1796140, ISSN: 0079-6123.

Brickey DA, Colbran RJ, Fong YL, Soderling TR. Expression and characterization of the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II using the baculovirus expression system. Biochem. Biophys. Res. Commun. 1990 Dec 12/14/1990; 173(2): 578-84. PMID: 2175600, PII: S0006-291X(05)80074-9, ISSN: 0006-291X.

Colbran RJ, Soderling TR. Calcium/calmodulin-independent autophosphorylation sites of calcium/calmodulin-dependent protein kinase II. Studies on the effect of phosphorylation of threonine 305/306 and serine 314 on calmodulin binding using synthetic peptides. J. Biol. Chem. 1990 Jul 7/5/1990; 265(19): 11213-9. PMID: 2162839, ISSN: 0021-9258.

Smith MK, Colbran RJ, Soderling TR. Specificities of autoinhibitory domain peptides for four protein kinases. Implications for intact cell studies of protein kinase function. J. Biol. Chem. 1990 Feb 2/5/1990; 265(4): 1837-40. PMID: 2153665, ISSN: 0021-9258.

Colbran RJ, Soderling TR. Calcium/calmodulin-dependent protein kinase II. Curr. Top. Cell. Regul. 1990; 31: 181-221. PMID: 2173993, ISSN: 0070-2137.

Soderling TR, Fukunaga K, Rich DP, Fong YL, Smith K, Colbran RJ. Regulation of brain Ca2+/calmodulin-dependent protein kinase II. Adv. Second Messenger Phosphoprotein Res. 1990; 24: 206-11. PMID: 2169799, ISSN: 1040-7952.

Rich, DP, Schworer, CM, Colbran, RJ Soderling, TR. Proteolytic activation of calcium/calmodulin dependent protein kinase II: Putative function in synaptic plasticity. Mol. Cell. Neurosci. 1990; 1: 107-16.

Rich DP, Colbran RJ, Schworer CM, Soderling TR. Regulatory properties of calcium/calmodulin-dependent protein kinase II in rat brain postsynaptic densities. J. Neurochem. 1989 Sep; 53(3): 807-16. PMID: 2547902, ISSN: 0022-3042.

Colbran RJ, Smith MK, Schworer CM, Fong YL, Soderling TR. Regulatory domain of calcium/calmodulin-dependent protein kinase II. Mechanism of inhibition and regulation by phosphorylation. J. Biol. Chem. 1989 Mar 3/25/1989; 264(9): 4800-4. PMID: 2538462, ISSN: 0021-9258.

Colbran RJ, Schworer CM, Hashimoto Y, Fong YL, Rich DP, Smith MK, Soderling TR. Calcium/calmodulin-dependent protein kinase II. Biochem. J. 1989 Mar 3/1/1989; 258(2): 313-25. PMID: 2539803, PMCID: PMC1138364, ISSN: 0264-6021.

Garton AJ, Campbell DG, Carling D, Hardie DG, Colbran RJ, Yeaman SJ. Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism. Eur. J. Biochem. 1989 Jan 1/15/1989; 179(1): 249-54. PMID: 2537200, ISSN: 0014-2956.

Colbran RJ, Fong YL, Schworer CM, Soderling TR. Regulatory interactions of the calmodulin-binding, inhibitory, and autophosphorylation domains of Ca2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 1988 Dec 12/5/1988; 263(34): 18145-51. PMID: 2848027, ISSN: 0021-9258.

Schworer CM, Colbran RJ, Keefer JR, Soderling TR. Ca2+/calmodulin-dependent protein kinase II. Identification of a regulatory autophosphorylation site adjacent to the inhibitory and calmodulin-binding domains. J. Biol. Chem. 1988 Sep 9/25/1988; 263(27): 13486-9. PMID: 3417668, ISSN: 0021-9258.

Payne ME, Fong YL, Ono T, Colbran RJ, Kemp BE, Soderling TR, Means AR. Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains. J. Biol. Chem. 1988 May 5/25/1988; 263(15): 7190-5. PMID: 2835367, ISSN: 0021-9258.

Hashimoto Y, Schworer CM, Colbran RJ, Soderling TR. Autophosphorylation of Ca2+/calmodulin-dependent protein kinase II. Effects on total and Ca2+-independent activities and kinetic parameters. J. Biol. Chem. 1987 Jun 6/15/1987; 262(17): 8051-5. PMID: 3110142, ISSN: 0021-9258.

Yeaman, SJ, Cordle, SR, Colbran, RJ, Garton, AJ, Honor, RC. In "Signal Transduction and Protein Phosphorylation" (L.M.G. Heilmeyer, Ed.) Plenum Press, New York. [place unknown: publisher unknown]; 1987.

Schworer CM, Colbran RJ, Soderling TR. Reversible generation of a Ca2+-independent form of Ca2+(calmodulin)-dependent protein kinase II by an autophosphorylation mechanism. J. Biol. Chem. 1986 Jul 7/5/1986; 261(19): 8581-4. PMID: 3722161, ISSN: 0021-9258.

Cordle SR, Colbran RJ, Yeaman SJ. Hormone-sensitive lipase from bovine adipose tissue. Biochim. Biophys. Acta. 1986 Jun 6/16/1986; 887(1): 51-7. PMID: 3708011, PII: 0167-4889(86)90121-7, ISSN: 0006-3002.

Colbran RJ, Garton AJ, Cordle SR, Yeaman SJ. Regulation of cholesterol ester hydrolase by cyclic AMP-dependent protein kinase. FEBS Lett. 1986 Jun 6/9/1986; 201(2): 257-61. PMID: 3011511, PII: 0014-5793(86)80619-6, ISSN: 0014-5793.

Cordle, SR, Colbran, RJ, Yeaman, SJ. Purification of hormone-sensitive lipase from bovine adipose tissue. Biochem. Soc. Trans. 1986; 14: 327-8.

Colbran, RJ, Yeaman, SJ. Reversible phosphorylation of cholesterol ester hydrolase. Biochem. Soc. Trans. 1985; 31: 874-5.

[place unknown: publisher unknown]; 1985.

Cook KG, Colbran RJ, Snee J, Yeaman SJ. Cytosolic cholesterol ester hydrolase from bovine corpus luteum. Its purification, identification, and relationship to hormone-sensitive lipase. Biochim. Biophys. Acta. 1983 Jun 6/16/1983; 752(1): 46-53. PMID: 6849967, PII: 0005-2760(83)90231-X, ISSN: 0006-3002.

Cook, KG, Colbran, RJ, Yeaman, SJ. The identity of cholesterol ester hydrolase of bovine corpus luteum. Biochem. Soc. Trans. 1983; 11: 703.

Available Postdoctoral Position Details
Signal Transduction/Molecular Neuroscience. See main research description. I am interested in motivated applicants with relevant experience in molecular biology, biochemistry, cell culture and/or electrophysiology. Interested individuals should submit their curriculum vitae, along with names and addresses of three individuals willing to provide references on their behalf, to: Dr. Roger Colbran, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615. FAX: 615-322-7236. Email: <A HREF="mailto:roger.colbran@vanderbilt.edu">roger.colbran@vanderbilt.edu.