L. Jackson Roberts, M.D.

Professor

jack.roberts@vanderbilt.edu
Faculty Appointments
Professor of Pharmacology William Stokes Chair in Experimental TherapeuticsProfessor of Medicine
Education
M.D., Medicine, University of Iowa, Iowa City, IowaB.A., Chemistry-Biology, Cornell College, Mt Vernon, Iowa
Office Address
522-A RRB
23rd & Pierce Ave.
Nashville, TN 37232-6602
Research Description
Free radicals primarily derived from oxygen have been implicated in a wide variety of diseases ranging from atherosclerosis, cancer, neurodegenerative diseases, and even the normal aging process. Free radicals readily attack lipids, proteins, and DNA resulting in mutations and deleterious effects on membrane and protein structure and function.

We discovered a series of novel products of free radical attack on lipids termed isoprostanes. Measurement of isoprostanes has emerged as the most reliable approach to assess free radical reactions in vivo. They also exert potent biological activities, which are currently being characterized. We have also discovered a series of similar compounds (neuroprostanes) formed by free radical attack on a unique lipid in the brain. Their role in neurodegenerative diseases is currently under investigation. Recently, we discovered novel highly reactive molecules that are produced by these pathways. These molecules rapidly adduct to proteins and we are currently exploring the pathobiological consequences of their formation in neurodegenerative and other diseases. More recently, we discovered new products of lipid peroxidation called isofurans whose formation is uniquely regulated by oxygen tension. Measurement of isofurans provides a unique tool to assess the role of oxidative injury in the setting of hyperoxia and in disorders of mitochondrial dysfunction. This provides ample opportunities for scientific investigation in a multidisciplinary area of research that is highly relevant to human disease. .
Research Keywords
Role of Free Radicals and Oxidative Injury in Human Disease
Publications
Przybysz AJ, Choe KP, Roberts LJ, Strange K. Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone. Mech. Ageing Dev [print-electronic]. 2009 Jun; 130(6): 357-69. PMID: 19428455, PMCID: PMC2680786, PII: S0047-6374(09)00037-2, DOI: 10.1016/j.mad.2009.02.004, ISSN: 1872-6216.

Roberts LJ, Milne GL. Isoprostanes. J. Lipid Res [print-electronic]. 2009 Apr; 50 Suppl: S219-23. PMID: 18957694, PMCID: PMC2674741, PII: R800037-JLR200, DOI: 10.1194/jlr.R800037-JLR200, ISSN: 0022-2275.

Hartert TV, Deng X, Hartman TJ, Wen W, Yang G, Gao YT, Jin M, Bai C, Gross M, Roberts LJ, Sheller JR, Christman J, Dupont W, Griffin M, Shu XO. The Shanghai Women's Asthma and Allergy Study: objectives, design, and recruitment results. Am. J. Epidemiol [print-electronic]. 2008 Jun 6/1/2008; 167(11): 1387-96. PMID: 18397914, PMCID: PMC2430736, PII: kwn057, DOI: 10.1093/aje/kwn057, ISSN: 1476-6256.

Roberts LJ. Inhibition of heme protein redox cycling: reduction of ferryl heme by iron chelators and the role of a novel through-protein electron transfer pathway. Free Radic. Biol. Med [print-electronic]. 2008 Feb 2/1/2008; 44(3): 257-60. PMID: 18067870, PII: S0891-5849(07)00725-3, DOI: 10.1016/j.freeradbiomed.2007.10.042, ISSN: 0891-5849.

Patel M, Liang LP, Hou H, Williams BB, Kmiec M, Swartz HM, Fessel JP, Roberts LJ 2nd.. Seizure-induced formation of isofurans: novel products of lipid peroxidation whose formation is positively modulated by oxygen tension. J Neurochem. 2008; 104((1)): 264-70.

Guo Z, Ran Q, Roberts LJ 2nd, Zhou L, Richardson A, Sharan C, Wu D, Yang H. Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. Free Radic Biol Med. 2008; 44((3)): 343-52.

Han ES, Muller FL, Perez V, Qi W, Liang H, Xi L, Fu C, Doyle E, Hickey M, Cornell J, Epstein CJ, Roberts LJ, Van Remmen H, Richardson A. The in vivo gene expression signature of oxidative stress. Physiol Genomics. 2008; 34((1)): 112-26.

Powers JS, Roberts LJ 2nd, Tarvin E, Hongu N, Choi L, Buchowski M. Oxidative stress and multi-organ failure in hospitalized elderly people. J Am Geriatr Soc. 2008; 56((6)): 1150-2.

Roberts, LJ, II. In Memoriam: Jason D. Morrow, MD (1957-2008). Free Rad Biol Med. 2008; 45: 1203-5.

Roberts LJ, Oates JA, Linton MF, Fazio S, Meador BP, Gross MD, Shyr Y, Morrow JD. The relationship between dose of vitamin E and suppression of oxidative stress in humans. Free Radic. Biol. Med [print-electronic]. 2007 Nov 11/15/2007; 43(10): 1388-93. PMID: 17936185, PMCID: PMC2072864, PII: S0891-5849(07)00455-8, DOI: 10.1016/j.freeradbiomed.2007.06.019, ISSN: 0891-5849.

Boyden PA, Davies SS, Viswanathan PC, Amarnath V, Balser JR, Roberts LJ. Potential role of isoketals formed via the isoprostane pathway of lipid peroxidation in ischemic arrhythmias. J. Cardiovasc. Pharmacol. 2007 Nov; 50(5): 480-6. PMID: 18030056, PII: 00005344-200711000-00003, DOI: 10.1097/FJC.0b013e31815a0564, ISSN: 0160-2446.

Wu P, Roberts LJ, Shintani AK, Sheller JR, Minton PA, Higgins SB, Hartert TV. Changes in urinary dinor dihydro F(2)-isoprostane metabolite concentrations, a marker of oxidative stress, during and following asthma exacerbations. Free Radic. Res. 2007 Sep; 41(9): 956-62. PMID: 17729112, PII: 781560664, DOI: 10.1080/10715760701444600, ISSN: 1071-5762.

Frisard MI, Broussard A, Davies SS, Roberts LJ, Rood J, de Jonge L, Fang X, Jazwinski SM, Deutsch WA, Ravussin E, . Aging, resting metabolic rate, and oxidative damage: results from the Louisiana Healthy Aging Study. J. Gerontol. A Biol. Sci. Med. Sci. 2007 Jul; 62(7): 752-9. PMID: 17634323, PMCID: PMC2692620, PII: 62/7/752, ISSN: 1079-5006.

Montuschi P, Barnes P, Roberts LJ. Insights into oxidative stress: the isoprostanes. Curr. Med. Chem. 2007; 14(6): 703-17. PMID: 17346157, ISSN: 0929-8673.

Ivester P, Roberts LJ, Young T, Stafforini D, Vivian J, Lees C, Young J, Daunais J, Friedman D, Rippe RA, Parsons CJ, Grant KA, Cunningham C. Ethanol self-administration and alterations in the livers of the cynomolgus monkey, Macaca fascicularis. Alcohol. Clin. Exp. Res. 2007 Jan; 31(1): 144-55. PMID: 17207113, PII: ACER276, DOI: 10.1111/j.1530-0277.2006.00276.x, ISSN: 0145-6008.

Davies SS, Amarnath V, Brame CJ, Boutaud O, Roberts LJ. Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin gamma-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry. Nat Protoc. 2007; 2(9): 2079-91. PMID: 17853863, PII: nprot.2007.298, DOI: 10.1038/nprot.2007.298, ISSN: 1750-2799.

Arneson KO, Roberts LJ. Measurement of products of docosahexaenoic acid peroxidation, neuroprostanes, and neurofurans. Meth. Enzymol. 2007; 433: 127-43. PMID: 17954232, PII: S0076-6879(07)33007-3, DOI: 10.1016/S0076-6879(07)33007-3, ISSN: 0076-6879.

Davies SS, Brantley EJ, Voziyan PA, Amarnath V, Zagol-Ikapitte I, Boutaud O, Hudson BG, Oates JA, Roberts LJ. Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity. Biochemistry [print-electronic]. 2006 Dec 12/26/2006; 45(51): 15756-67. PMID: 17176098, PMCID: PMC2597444, DOI: 10.1021/bi061860g, ISSN: 1520-4995.

Montgomery-Downs HE, Krishna J, Roberts LJ, Gozal D. Urinary F2-isoprostane metabolite levels in children with sleep-disordered breathing. Sleep Breath. 2006 Dec; 10(4): 211-5. PMID: 17028846, DOI: 10.1007/s11325-006-0079-5, ISSN: 1520-9512.

Gustafson EJ, Roberts LJ, Leefers LA. Linking linear programming and spatial simulation models to predict landscape effects of forest management alternatives. J. Environ. Manage [print-electronic]. 2006 Dec; 81(4): 339-50. PMID: 16549235, PII: S0301-4797(05)00360-9, DOI: 10.1016/j.jenvman.2005.11.009, ISSN: 0301-4797.

Cotton RB, Hazinski TA, Morrow JD, Roberts LJ, Zeldin DC, Lindstrom DP, Lappalainen U, Law AB, Steele S. Cimetidine does not prevent lung injury in newborn premature infants. Pediatr. Res [print-electronic]. 2006 Jun; 59(6): 795-800. PMID: 16641218, PMCID: PMC2367235, PII: 01.pdr.0000219397.35473.5f, DOI: 10.1203/01.pdr.0000219397.35473.5f, ISSN: 0031-3998.

Jakupcak M, Roberts LJ, Martell C, Mulick P, Michael S, Reed R, Balsam KF, Yoshimoto D, McFall M. A pilot study of behavioral activation for veterans with posttraumatic stress disorder. J Trauma Stress. 2006 Jun; 19(3): 387-91. PMID: 16789005, DOI: 10.1002/jts.20125, ISSN: 0894-9867.

Muller FL, Song W, Liu Y, Chaudhuri A, Pieke-Dahl S, Strong R, Huang TT, Epstein CJ, Roberts LJ, Csete M, Faulkner JA, Van Remmen H. Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy. Free Radic. Biol. Med [print-electronic]. 2006 Jun 6/1/2006; 40(11): 1993-2004. PMID: 16716900, PII: S0891-5849(06)00090-6, DOI: 10.1016/j.freeradbiomed.2006.01.036, ISSN: 0891-5849.

Gaut JP, Belaaouaj A, Byun J, Roberts LJ, Maeda N, Frei B, Heinecke JW. Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation. Free Radic. Biol. Med [print-electronic]. 2006 May 5/1/2006; 40(9): 1494-501. PMID: 16632110, PII: S0891-5849(05)00748-3, DOI: 10.1016/j.freeradbiomed.2005.12.013, ISSN: 0891-5849.

Talati M, Meyrick B, Peebles RS, Davies SS, Dworski R, Mernaugh R, Mitchell D, Boothby M, Roberts LJ, Sheller JR. Oxidant stress modulates murine allergic airway responses. Free Radic. Biol. Med [print-electronic]. 2006 Apr 4/1/2006; 40(7): 1210-9. PMID: 16545689, PII: S0891-5849(05)00710-0, DOI: 10.1016/j.freeradbiomed.2005.11.012, ISSN: 0891-5849.

Dutta UK, Lane J, Roberts LJ, Majid DS. Superoxide formation and interaction with nitric oxide modulate systemic arterial pressure and renal function in salt-depleted dogs. Exp. Biol. Med. (Maywood). 2006 Mar; 231(3): 269-76. PMID: 16514172, PII: 231/3/269, ISSN: 1535-3702.

Stafforini DM, Sheller JR, Blackwell TS, Sapirstein A, Yull FE, McIntyre TM, Bonventre JV, Prescott SM, Roberts LJ. Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases. J. Biol. Chem [print-electronic]. 2006 Feb 2/24/2006; 281(8): 4616-23. PMID: 16371369, PII: M507340200, DOI: 10.1074/jbc.M507340200, ISSN: 0021-9258.

Roberts LJ, Cleland LG, Thomas R, Proudman SM. Early combination disease modifying antirheumatic drug treatment for rheumatoid arthritis. Med. J. Aust. 2006 Feb 2/6/2006; 184(3): 122-5. PMID: 16460297, PII: rob10479_fm, ISSN: 0025-729X.

Davies SS, Zackert W, Luo Y, Cunningham CC, Frisard M, Roberts LJ. Quantification of dinor, dihydro metabolites of F2-isoprostanes in urine by liquid chromatography/tandem mass spectrometry. Anal. Biochem [print-electronic]. 2006 Jan 1/15/2006; 348(2): 185-91. PMID: 16309621, PII: S0003-2697(05)00729-3, DOI: 10.1016/j.ab.2005.10.012, ISSN: 0003-2697.

Cotton RB, Sundell HW, Zeldin DC, Morrow JD, Roberts LJ, Hazinski TA, Law AB, Steele S. Inhaled nitric oxide attenuates hyperoxic lung injury in lambs. Pediatr. Res [print-electronic]. 2006 Jan; 59(1): 142-6. PMID: 16327001, PII: 01.pdr.0000191815.60293.cc, DOI: 10.1203/01.pdr.0000191815.60293.cc, ISSN: 0031-3998.

Fukuda K, Davies SS, Nakajima T, Ong BH, Kupershmidt S, Fessel J, Amarnath V, Anderson ME, Boyden PA, Viswanathan PC, Roberts LJ, Balser JR. Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels. Circ. Res [print-electronic]. 2005 Dec 12/9/2005; 97(12): 1262-9. PMID: 16284182, PII: 01.RES.0000195844.31466.e9, DOI: 10.1161/01.RES.0000195844.31466.e9, ISSN: 1524-4571.

Kwan KS, Roberts LJ, Swalm DM. Sexual dysfunction and chronic pain: the role of psychological variables and impact on quality of life. Eur J Pain [print-electronic]. 2005 Dec; 9(6): 643-52. PMID: 16246817, PII: S1090-3801(04)00174-0, DOI: 10.1016/j.ejpain.2004.12.008, ISSN: 1090-3801.

Idris AH, Roberts LJ, Caruso L, Showstark M, Layon AJ, Becker LB, Vanden Hoek T, Gabrielli A. Oxidant injury occurs rapidly after cardiac arrest, cardiopulmonary resuscitation, and reperfusion. Crit. Care Med. 2005 Sep; 33(9): 2043-8. PMID: 16148478, PII: 00003246-200509000-00022, ISSN: 0090-3493.

Ward WF, Qi W, Van Remmen H, Zackert WE, Roberts LJ, Richardson A. Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels. J. Gerontol. A Biol. Sci. Med. Sci. 2005 Jul; 60(7): 847-51. PMID: 16079206, PII: 60/7/847, ISSN: 1079-5006.

Roberts LJ, Huffam SE, Walton SF, Currie BJ. Crusted scabies: clinical and immunological findings in seventy-eight patients and a review of the literature. J. Infect. 2005 Jun; 50(5): 375-81. PMID: 15907543, PII: S0163-4453(04)00212-9, DOI: 10.1016/j.jinf.2004.08.033, ISSN: 0163-4453.

Roberts LJ, Fessel JP, Davies SS. The biochemistry of the isoprostane, neuroprostane, and isofuran Pathways of lipid peroxidation. Brain Pathol. 2005 Apr; 15(2): 143-8. PMID: 15912887, ISSN: 1015-6305.

Kadiiska MB, Gladen BC, Baird DD, Graham LB, Parker CE, Ames BN, Basu S, Fitzgerald GA, Lawson JA, Marnett LJ, Morrow JD, Murray DM, Plastaras J, Roberts LJ, Rokach J, Shigenaga MK, Sun J, Walter PB, Tomer KB, Barrett JC, Mason RP. Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free Radic. Biol. Med. 2005 Mar 3/15/2005; 38(6): 711-8. PMID: 15721981, PII: S0891-5849(04)00847-0, DOI: 10.1016/j.freeradbiomed.2004.10.024, ISSN: 0891-5849.

Kadiiska MB, Gladen BC, Baird DD, Germolec D, Graham LB, Parker CE, Nyska A, Wachsman JT, Ames BN, Basu S, Brot N, Fitzgerald GA, Floyd RA, George M, Heinecke JW, Hatch GE, Hensley K, Lawson JA, Marnett LJ, Morrow JD, Murray DM, Plastaras J, Roberts LJ, Rokach J, Shigenaga MK, Sohal RS, Sun J, Tice RR, Van Thiel DH, Wellner D, Walter PB, Tomer KB, Mason RP, Barrett JC. Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?. Free Radic. Biol. Med. 2005 Mar 3/15/2005; 38(6): 698-710. PMID: 15721980, PII: S0891-5849(04)00742-7, DOI: 10.1016/j.freeradbiomed.2004.09.017, ISSN: 0891-5849.

Shibao C, Arzubiaga C, Roberts LJ, Raj S, Black B, Harris P, Biaggioni I. Hyperadrenergic postural tachycardia syndrome in mast cell activation disorders. Hypertension [print-electronic]. 2005 Mar; 45(3): 385-90. PMID: 15710782, PII: 01.HYP.0000158259.68614.40, DOI: 10.1161/01.HYP.0000158259.68614.40, ISSN: 1524-4563.

Canter JA, Eshaghian A, Fessel J, Summar ML, Roberts LJ, Morrow JD, Sligh JE, Haines JL. Degree of heteroplasmy reflects oxidant damage in a large family with the mitochondrial DNA A8344G mutation. Free Radic. Biol. Med. 2005 Mar 3/1/2005; 38(5): 678-83. PMID: 15683723, PII: S0891-5849(04)00963-3, DOI: 10.1016/j.freeradbiomed.2004.11.031, ISSN: 0891-5849.

Habbu JH, Hayman R, Roberts LJ. Tuberous sclerosis in an antenatally diagnosed cardiac rhabdomyoma. J Obstet Gynaecol. 2005 Feb; 25(2): 193-4. PMID: 15814405, PII: T72H01P14302K127, DOI: 10.1080/01443610500051304, ISSN: 0144-3615.

Ran Q, Liang H, Gu M, Qi W, Walter CA, Roberts LJ, Herman B, Richardson A, Van Remmen H. Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J. Biol. Chem [print-electronic]. 2004 Dec 12/31/2004; 279(53): 55137-46. PMID: 15496407, PII: M410387200, DOI: 10.1074/jbc.M410387200, ISSN: 0021-9258.

Roberts LJ. New drugs for rheumatoid arthritis [letter]. N. Engl. J. Med. 2004 Dec 12/16/2004; 351(25): 2659-61; author reply 2659. PMID: 15602032, PII: 351/25/2659, DOI: 10.1056/NEJM200412163512522, ISSN: 1533-4406.

Montuschi P, Barnes PJ, Roberts LJ. Isoprostanes: markers and mediators of oxidative stress. FASEB J. 2004 Dec; 18(15): 1791-800. PMID: 15576482, PII: 18/15/1791, DOI: 10.1096/fj.04-2330rev, ISSN: 1530-6860.

Friel JK, Friesen RW, Harding SV, Roberts LJ. Evidence of oxidative stress in full-term healthy infants. Pediatr. Res [print-electronic]. 2004 Dec; 56(6): 878-82. PMID: 15470194, PII: 01.PDR.0000146032.98120.43, DOI: 10.1203/01.PDR.0000146032.98120.43, ISSN: 0031-3998.

Yang H, Roberts LJ, Shi MJ, Zhou LC, Ballard BR, Richardson A, Guo ZM. Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E. Circ. Res [print-electronic]. 2004 Nov 11/26/2004; 95(11): 1075-81. PMID: 15528470, PII: 01.RES.0000149564.49410.0d, DOI: 10.1161/01.RES.0000149564.49410.0d, ISSN: 1524-4571.

Bernoud-Hubac N, Fay LB, Armarnath V, Guichardant M, Bacot S, Davies SS, Roberts LJ, Lagarde M. Covalent binding of isoketals to ethanolamine phospholipids. Free Radic. Biol. Med. 2004 Nov 11/15/2004; 37(10): 1604-11. PMID: 15477011, PII: S0891-5849(04)00607-0, DOI: 10.1016/j.freeradbiomed.2004.07.031, ISSN: 0891-5849.

Mun-Bryce S, Roberts LJ, Hunt WC, Bartolo A, Okada Y. Acute changes in cortical excitability in the cortex contralateral to focal intracerebral hemorrhage in the swine. Brain Res. 2004 Nov 11/12/2004; 1026(2): 218-26. PMID: 15488483, PII: S0006-8993(04)01342-3, DOI: 10.1016/j.brainres.2004.08.023, ISSN: 0006-8993.

Wu T, Rifai N, Roberts LJ, Willett WC, Rimm EB. Stability of measurements of biomarkers of oxidative stress in blood over 36 hours. Cancer Epidemiol. Biomarkers Prev. 2004 Aug; 13(8): 1399-402. PMID: 15298964, PII: 13/8/1399, ISSN: 1055-9965.

Carey KB, Roberts LJ, Kivlahan DR, Carey MP, Neal DJ. Problems assessment for substance using psychiatric patients: development and initial psychometric evaluation. Drug Alcohol Depend. 2004 Jul 7/15/2004; 75(1): 67-77. PMID: 15225890, PII: S0376871604000365, DOI: 10.1016/j.drugalcdep.2004.01.010, ISSN: 0376-8716.

Zagol-Ikapitte I, Bernoud-Hubac N, Amarnath V, Roberts LJ, Boutaud O, Oates JA. Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine. Biochemistry. 2004 May 5/11/2004; 43(18): 5503-10. PMID: 15122916, DOI: 10.1021/bi049842r, ISSN: 0006-2960.

Davies SS, Talati M, Wang X, Mernaugh RL, Amarnath V, Fessel J, Meyrick BO, Sheller J, Roberts LJ. Localization of isoketal adducts in vivo using a single-chain antibody. Free Radic. Biol. Med. 2004 May 5/1/2004; 36(9): 1163-74. PMID: 15082070, PII: S0891584904001315, DOI: 10.1016/j.freeradbiomed.2004.02.014, ISSN: 0891-5849.

Brame CJ, Boutaud O, Davies SS, Yang T, Oates JA, Roden D, Roberts LJ. Modification of proteins by isoketal-containing oxidized phospholipids. J. Biol. Chem [print-electronic]. 2004 Apr 4/2/2004; 279(14): 13447-51. PMID: 14715668, PII: M313349200, DOI: 10.1074/jbc.M313349200, ISSN: 0021-9258.

Browne SE, Roberts LJ, Dennery PA, Doctrow SR, Beal MF, Barlow C, Levine RL. Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice. Free Radic. Biol. Med. 2004 Apr 4/1/2004; 36(7): 938-42. PMID: 15019978, PII: S0891584904000358, DOI: 10.1016/j.freeradbiomed.2004.01.003, ISSN: 0891-5849.

Roberts LJ, Fessel JP. The biochemistry of the isoprostane, neuroprostane, and isofuran pathways of lipid peroxidation. Chem. Phys. Lipids. 2004 Mar; 128(1-2): 173-86. PMID: 15037162, PII: S0009308403001403, DOI: 10.1016/j.chemphyslip.2003.09.016, ISSN: 0009-3084.

Davies SS, Amarnath V, Roberts LJ. Isoketals: highly reactive gamma-ketoaldehydes formed from the H2-isoprostane pathway. Chem. Phys. Lipids. 2004 Mar; 128(1-2): 85-99. PMID: 15037155, PII: S0009308403001567, DOI: 10.1016/j.chemphyslip.2003.10.007, ISSN: 0009-3084.

Amarnath V, Amarnath K, Amarnath K, Davies S, Roberts LJ. Pyridoxamine: an extremely potent scavenger of 1,4-dicarbonyls. Chem. Res. Toxicol. 2004 Mar; 17(3): 410-5. PMID: 15025512, DOI: 10.1021/tx0300535, ISSN: 0893-228X.

Montine KS, Quinn JF, Zhang J, Fessel JP, Roberts LJ, Morrow JD, Montine TJ. Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. Chem. Phys. Lipids. 2004 Mar; 128(1-2): 117-24. PMID: 15037157, PII: S0009308403001592, DOI: 10.1016/j.chemphyslip.2003.10.010, ISSN: 0009-3084.

Lim E, Wicks I, Roberts LJ. Intracardiac thrombosis complicating antiphospholipid antibody syndrome. Intern Med J. 2004 Mar; 34(3): 135-7. PMID: 15030465, PII: IMJ558, DOI: 10.1111/j.1444-0903.2004.00558.x, ISSN: 1444-0903.

Elso CM, Roberts LJ, Smyth GK, Thomson RJ, Baldwin TM, Foote SJ, Handman E. Leishmaniasis host response loci (lmr1-3) modify disease severity through a Th1/Th2-independent pathway. Genes Immun. 2004 Mar; 5(2): 93-100. PMID: 14668789, PII: 6364042, DOI: 10.1038/sj.gene.6364042, ISSN: 1466-4879.

Hou X, Roberts LJ, Gobeil F, Taber D, Kanai K, Abran D, Brault S, Checchin D, Sennlaub F, Lachapelle P, Varma D, Chemtob S. Isomer-specific contractile effects of a series of synthetic f2-isoprostanes on retinal and cerebral microvasculature. Free Radic. Biol. Med. 2004 Jan 1/15/2004; 36(2): 163-72. PMID: 14744628, PII: S0891584903007482, ISSN: 0891-5849.

Ilsley JN, Belinsky GS, Guda K, Zhang Q, Huang X, Blumberg JB, Milbury PE, Roberts LJ, Stevens RG, Rosenberg DW. Dietary iron promotes azoxymethane-induced colon tumors in mice. Nutr Cancer. 2004; 49(2): 162-9. PMID: 15489209, DOI: 10.1207/s15327914nc4902_7, ISSN: 0163-5581.

Taber DF, Fessel JP, Roberts LJ. A nomenclature system for isofurans. Prostaglandins Other Lipid Mediat. 2004 Jan; 73(1-2): 47-50. PMID: 15165030, ISSN: 1098-8823.

Vorster AA, Rebello MT, Coutts N, Ehrenreich L, Gama AD, Roberts LJ, Goliath R, Ramesar R, Greenberg LJ. Arg120stop nonsense mutation in the RP2 gene: mutational hotspot and germ line mosaicism?. Clin. Genet. 2004 Jan; 65(1): 7-10. PMID: 15032968, PII: CGE163, DOI: 10.1111/j.2004.00163.x, ISSN: 0009-9163.

Huang H, He Z, Roberts LJ, Salahudeen AK. Deferoxamine reduces cold-ischemic renal injury in a syngeneic kidney transplant model. Am. J. Transplant. 2003 Dec; 3(12): 1531-7. PMID: 14629283, ISSN: 1600-6135.

Roberts LJ, Thackray M. Recovery intervention to manage severe pain: comparing apples with oranges? [letter]. Anaesth Intensive Care. 2003 Dec; 31(6): 699-700. PMID: 14719437, ISSN: 0310-057X.

Ran Q, Van Remmen H, Gu M, Qi W, Roberts LJ, Prolla T, Richardson A. Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processes. Free Radic. Biol. Med. 2003 Nov 11/1/2003; 35(9): 1101-9. PMID: 14572612, PII: S0891584903004660, ISSN: 0891-5849.

Campbell IK, Roberts LJ, Wicks IP. Molecular targets in immune-mediated diseases: the case of tumour necrosis factor and rheumatoid arthritis. Immunol. Cell Biol. 2003 Oct; 81(5): 354-66. PMID: 12969323, PII: 1185, DOI: 10.1046/j.0818-9641.2003.01185.x, ISSN: 0818-9641.

Shaner A, Eckman T, Roberts LJ, Fuller T. Feasibility of a skills training approach to reduce substance dependence among individuals with schizophrenia. Psychiatr Serv. 2003 Sep; 54(9): 1287-9. PMID: 12954948, DOI: 10.1176/appi.ps.54.9.1287, ISSN: 1075-2730.

Swanson SP, Roberts LJ, Chapman MD. Are anaesthetists prone to suicide? A review of rates and risk factors. Anaesth Intensive Care. 2003 Aug; 31(4): 434-45. PMID: 12973968, ISSN: 0310-057X.

Boutaud O, Li J, Zagol I, Shipp EA, Davies SS, Roberts LJ, Oates JA. Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation. J. Biol. Chem [print-electronic]. 2003 May 5/9/2003; 278(19): 16926-8. PMID: 12637576, PII: M300940200, DOI: 10.1074/jbc.M300940200, ISSN: 0021-9258.

Fessel JP, Hulette C, Powell S, Roberts LJ, Zhang J. Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease. J. Neurochem. 2003 May; 85(3): 645-50. PMID: 12694390, PII: 1709, ISSN: 0022-3042.

Willcox JK, Catignani GL, Roberts LJ. Dietary flavonoids fail to suppress F2-isoprostane formation in vivo. Free Radic. Biol. Med. 2003 Apr 4/1/2003; 34(7): 795-9. PMID: 12654466, PII: S0891584902014259, ISSN: 0891-5849.

Fortepiani LA, Zhang H, Racusen L, Roberts LJ, Reckelhoff JF. Characterization of an animal model of postmenopausal hypertension in spontaneously hypertensive rats. Hypertension [print-electronic]. 2003 Mar; 41(3 Pt 2): 640-5. PMID: 12623972, PII: 01.HYP.0000046924.94886.EF, DOI: 10.1161/01.HYP.0000046924.94886.EF, ISSN: 1524-4563.

Davies SS, Ju WK, Neufeld AH, Abran D, Chemtob S, Roberts LJ. Hydrolysis of bimatoprost (Lumigan) to its free acid by ocular tissue in vitro. J Ocul Pharmacol Ther. 2003 Feb; 19(1): 45-54. PMID: 12648303, DOI: 10.1089/108076803762718105, ISSN: 1080-7683.

Jha S, Roberts LJ. Acrania. J Obstet Gynaecol. 2003 Jan; 23(1): 78. PMID: 12647707, ISSN: 0144-3615.

Fessel JP, Porter NA, Moore KP, Sheller JR, Roberts LJ. Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2002 Dec 12/24/2002; 99(26): 16713-8. PMID: 12482927, PMCID: PMC139209, PII: 252649099, DOI: 10.1073/pnas.252649099, ISSN: 0027-8424.

Morrow JD, Roberts LJ. The isoprostanes: their role as an index of oxidant stress status in human pulmonary disease. Am. J. Respir. Crit. Care Med. 2002 Dec 12/15/2002; 166(12 Pt 2): S25-30. PMID: 12471085, PII: 166/12 Pt 2/S25, DOI: 10.1164/rccm.2206011, ISSN: 1073-449X.

Fam SS, Murphey LJ, Terry ES, Zackert WE, Chen Y, Gao L, Pandalai S, Milne GL, Roberts LJ, Porter NA, Montine TJ, Morrow JD. Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid. J. Biol. Chem [print-electronic]. 2002 Sep 9/27/2002; 277(39): 36076-84. PMID: 12133837, PII: M205638200, DOI: 10.1074/jbc.M205638200, ISSN: 0021-9258.

Bernoud-Hubac N, Roberts LJ. Identification of oxidized derivatives of neuroketals. Biochemistry. 2002 Sep 9/24/2002; 41(38): 11466-71. PMID: 12234189, PII: bi0257383, ISSN: 0006-2960.

Ikizler TA, Morrow JD, Roberts LJ, Evanson JA, Becker B, Hakim RM, Shyr Y, Himmelfarb J. Plasma F2-isoprostane levels are elevated in chronic hemodialysis patients. Clin. Nephrol. 2002 Sep; 58(3): 190-7. PMID: 12356187, ISSN: 0301-0430.

Montine TJ, Neely MD, Quinn JF, Beal MF, Markesbery WR, Roberts LJ, Morrow JD. Lipid peroxidation in aging brain and Alzheimer's disease. Free Radic. Biol. Med. 2002 Sep 9/1/2002; 33(5): 620-6. PMID: 12208348, PII: S0891584902008079, ISSN: 0891-5849.

Hubatsch I, Mannervik B, Gao L, Roberts LJ, Chen Y, Morrow JD. The cyclopentenone product of lipid peroxidation, 15-A(2t)-isoprostane (8-isoprostaglandin A(2)), is efficiently conjugated with glutathione by human and rat glutathione transferase A4-4. Chem. Res. Toxicol. 2002 Sep; 15(9): 1114-8. PMID: 12230403, PII: tx020027r, ISSN: 0893-228X.

Meng S, Roberts LJ, Cason GW, Curry TS, Manning RD. Superoxide dismutase and oxidative stress in Dahl salt-sensitive and -resistant rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2002 Sep; 283(3): R732-8. PMID: 12185008, DOI: 10.1152/ajpregu.00346.2001, ISSN: 0363-6119.

Wells N, Roberts L, Medlin LC. Issues related to staff retention and turnover. Semin Nurse Manag. 2002 Sep; 10(3): 171-9. PMID: 12271763, ISSN: 1066-3851.

Montine TJ, Quinn JF, Milatovic D, Silbert LC, Dang T, Sanchez S, Terry E, Roberts LJ, Kaye JA, Morrow JD. Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease. Ann. Neurol. 2002 Aug; 52(2): 175-9. PMID: 12210787, DOI: 10.1002/ana.10272, ISSN: 0364-5134.

Milatovic D, Zhang Y, Olson SJ, Montine KS, Roberts LJ, Morrow JD, Montine TJ, Dermody TS, Valyi-Nagy T. Herpes simplex virus type 1 encephalitis is associated with elevated levels of F2-isoprostanes and F4-neuroprostanes. J. Neurovirol. 2002 Aug; 8(4): 295-305. PMID: 12161814, DOI: 10.1080/13550280290100743, ISSN: 1355-0284.

Roberts LJ, Khursandi DC. Career choice influences in Australian anaesthetists. Anaesth Intensive Care. 2002 Jun; 30(3): 355-9. PMID: 12075645, ISSN: 0310-057X.

Roberts LJ, Morrow JD. Products of the isoprostane pathway: unique bioactive compounds and markers of lipid peroxidation. Cell. Mol. Life Sci. 2002 May; 59(5): 808-20. PMID: 12088281, ISSN: 1420-682X.

Davies SS, Amarnath V, Montine KS, Bernoud-Hubac N, Boutaud O, Montine TJ, Roberts LJ. Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function. FASEB J [print-electronic]. 2002 May; 16(7): 715-7. PMID: 11978738, PII: 01-0696fje, DOI: 10.1096/fj.01-0696fje, ISSN: 1530-6860.

Roberts LJ, Finch PM, Pullan PT, Bhagat CI, Price LM. Sex hormone suppression by intrathecal opioids: a prospective study. Clin J Pain. 2002 May; 18(3): 144-8. PMID: 12048415, ISSN: 0749-8047.

Miller ET, Neal DJ, Roberts LJ, Baer JS, Cressler SO, Metrik J, Marlatt GA. Test-retest reliability of alcohol measures: is there a difference between internet-based assessment and traditional methods?. Psychol Addict Behav. 2002 Mar; 16(1): 56-63. PMID: 11934087, ISSN: 0893-164X.

Vanharanta M, Voutilainen S, Nurmi T, Kaikkonen J, Roberts LJ, Morrow JD, Adlercreutz H, Salonen JT. Association between low serum enterolactone and increased plasma F2-isoprostanes, a measure of lipid peroxidation. Atherosclerosis. 2002 Feb; 160(2): 465-9. PMID: 11849672, PII: S0021-9150(01)00603-7, ISSN: 0021-9150.

Morrow JD, Roberts LJ. Mass spectrometric quantification of F2-isoprostanes as indicators of oxidant stress. Methods Mol. Biol. 2002; 186: 57-66. PMID: 12013785, DOI: 10.1385/1-59259-173-6:57, ISSN: 1064-3745.

Youssef J, Davis A, Roberts LJ, Swift LL, Morrow JD, Badr M. Pantothenic acid: an organ-specific pro-oxidant vitamin. Brain and liver neuroprostane levels in rats fed a pantothenic acid-deficient diet. Adv. Exp. Med. Biol. 2002; 507: 551-5. PMID: 12664639, ISSN: 0065-2598.

Sasaki DM, Yuan Y, Gikas K, Kanai K, Taber D, Morrow JD, Roberts LJ, Callewaert DM. Enzyme immunoassays for 15-F2T isoprostane-M, an urinary biomarker for oxidant stress. Adv. Exp. Med. Biol. 2002; 507: 537-41. PMID: 12664637, ISSN: 0065-2598.

Jha S, Haldar MK, Roberts LJ. Primary ovarian pregnancy with an intrauterine contraceptive device in situ. J Obstet Gynaecol. 2002 Jan; 22(1): 104-5. PMID: 12521754, PII: 47JF5BNA802BPH1X, ISSN: 0144-3615.

Kaikkonen J, Porkkala-Sarataho E, Morrow JD, Roberts LJ, Nyyssönen K, Salonen R, Tuomainen TP, Ristonmaa U, Poulsen HE, Salonen JT. Supplementation with vitamin E but not with vitamin C lowers lipid peroxidation in vivo in mildly hypercholesterolemic men. Free Radic. Res. 2001 Dec; 35(6): 967-78. PMID: 11811547, ISSN: 1071-5762.

Patel M, Liang LP, Roberts LJ. Enhanced hippocampal F2-isoprostane formation following kainate-induced seizures. J. Neurochem. 2001 Dec; 79(5): 1065-9. PMID: 11739620, ISSN: 0022-3042.

Salahudeen AK, Oliver B, Bower JD, Roberts LJ. Increase in plasma esterified F2-isoprostanes following intravenous iron infusion in patients on hemodialysis. Kidney Int. 2001 Oct; 60(4): 1525-31. PMID: 11576368, PII: kid976, DOI: 10.1046/j.1523-1755.2001.00976.x, ISSN: 0085-2538.

Roberts LJ, Reckelhoff JF. Measurement of F(2)-isoprostanes unveils profound oxidative stress in aged rats. Biochem. Biophys. Res. Commun. 2001 Sep 9/14/2001; 287(1): 254-6. PMID: 11549283, PII: S0006-291X(01)95583-4, DOI: 10.1006/bbrc.2001.5583, ISSN: 0006-291X.

Bernoud-Hubac N, Davies SS, Boutaud O, Montine TJ, Roberts LJ. Formation of highly reactive gamma-ketoaldehydes (neuroketals) as products of the neuroprostane pathway. J. Biol. Chem [print-electronic]. 2001 Aug 8/17/2001; 276(33): 30964-70. PMID: 11413140, PII: M103768200, DOI: 10.1074/jbc.M103768200, ISSN: 0021-9258.

Reich EE, Montine KS, Gross MD, Roberts LJ, Swift LL, Morrow JD, Montine TJ. Interactions between apolipoprotein E gene and dietary alpha-tocopherol influence cerebral oxidative damage in aged mice. J. Neurosci. 2001 Aug 8/15/2001; 21(16): 5993-9. PMID: 11487622, PII: 21/16/5993, ISSN: 1529-2401.

Hou X, Roberts LJ, Taber DF, Morrow JD, Kanai K, Gobeil F, Beauchamp MH, Bernier SG, Lepage G, Varma DR, Chemtob S. 2,3-Dinor-5,6-dihydro-15-F(2t)-isoprostane: a bioactive prostanoid metabolite. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001 Aug; 281(2): R391-400. PMID: 11448840, ISSN: 0363-6119.

Boutaud O, Brame CJ, Chaurand P, Li J, Rowlinson SW, Crews BC, Ji C, Marnett LJ, Caprioli RM, Roberts LJ, Oates JA. Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid. Biochemistry. 2001 Jun 6/12/2001; 40(23): 6948-55. PMID: 11389610, PII: bi002629k, ISSN: 0006-2960.

Roberts LJ, Goucke CR. Retro-orbital tumour--an uncommon cause of headache in pregnancy. Anaesth Intensive Care. 2001 Jun; 29(3): 276-80. PMID: 11439800, ISSN: 0310-057X.

Marathe GK, Harrison KA, Roberts LJ, Morrow JD, Murphy RC, Tjoelker LW, Prescott SM, Zimmerman GA, McIntyre TM. Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver. J. Lipid Res. 2001 Apr; 42(4): 587-96. PMID: 11290831, ISSN: 0022-2275.

Dworski R, Roberts LJ, Murray JJ, Morrow JD, Hartert TV, Sheller JR. Assessment of oxidant stress in allergic asthma by measurement of the major urinary metabolite of F2-isoprostane, 15-F2t-IsoP (8-iso-PGF2alpha). Clin. Exp. Allergy. 2001 Mar; 31(3): 387-90. PMID: 11260149, PII: cea1055, ISSN: 0954-7894.

Hou X, Roberts LJ, II, Morrow JD, Taber DF, Kanai K, Gobeil F, Varma DR, and Chemtob S. 2,3-Dinor-5,6-dihydro-15-F2t-isoprostane is a bioactive isoprostane metabolite. 2001.

Boutand O, Brame CJ, Chaurand, P, Scott JL, Rowlinson SE, Crews BC, Chuan J, Marnett LJ, Roberts LJ, II, and Oates, JA. Characterization of the adducts of prostaglandin H synthases that are derived from oxygenation of arachidonic acid. 2001.

Lahaie O, Hardy P, Hou X, Hassessian H, Asselin P, Lachapelle P, Almazan G, Varma DR, Roberts LJ, II, and Chemtob S. Cytotoxic effects of thromboxane on neurovascular endothelial cells: Possible role in ischemic neuropathies. 2001.

Marathe GK, Harrison KA, Roberts LJ, II, Morrow JD, Murphy RC, Tjoelker LW, Prescott SM, Zimmerman GA, and McIntyre TM. Identification of platelet activating factor as the inflammatory lipid mediator in CCL4-induced rat liver damage. 2001.

Dworski, R, Murray, JJ, Roberts, LJ, II, Oates, JA, Morrow, JD, Hartert, T, and Sheller, JR. Assment of oxidant stress in allergic asthma by measurement of the major urinary metabolite of F2-isoprostane, 15-F2t-IsoP (8-iso-PGF2 ). 2001.

Youssef J, Birnbaum L, Roberts, LJ, II, Swift LL, Morrow J, and Badr M. Brain oxidative stress, senescence and death. Isoprostanes and neuroprostanes: novel markers and new theories. 2001.

Barany P, Stenvinkel P, Ottosson-Seeberger, Alvestrand A, Morrow JD, Roberts LJ, II, and Salahudeen A. Effect of 6-weeks of vitamin E administration on renal hemodynamic alterations following a single dose of Neoral in healthy volunteers. 2001.

Reich EE, Markesbery WR, Roberts LJ, II, Swift LL, Morrow JD, and Montine, TJ. Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. 2001.

Reich EE, Montine KS, Gross M, Roberts LJ, II, Swift LL, Morrow JD, and Montine TJ. Interactions between apolipoprotein E gene and dietary -tocopherol influence cerebral oxidative damage in aged mice. 2001.

Bernoud-Hubac N, Davies SS, Boutaud O, Montine TJ, and Roberts LJ, II. Formation of highly reactive -ketoaldehydes (neuroketals) as products of the neuroprostane pathway. 2001.

Reich EE, Markesbery WR, Roberts LJ, Swift LL, Morrow JD, Montine TJ. Quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. Adv. Exp. Med. Biol. 2001; 500: 253-6. PMID: 11764949, ISSN: 0065-2598.

Boutaud O, Li J, Chaurand P, Brame CJ, Marnett LJ, Roberts LJ, Oates JA. Oxygenation of arachidonic acid by cyclooxygenases generates reactive intermediates that form adducts with proteins. Adv. Exp. Med. Biol. 2001; 500: 133-7. PMID: 11764925, ISSN: 0065-2598.

Reich EE, Markesbery WR, Roberts LJ, Swift LL, Morrow JD, Montine TJ. Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. Am. J. Pathol. 2001 Jan; 158(1): 293-7. PMID: 11141503, PMCID: PMC1850257, PII: S0002-9440(10)63968-5, DOI: 10.1016/S0002-9440(10)63968-5, ISSN: 0002-9440.

Roberts LJ, Finch PM, Goucke CR, Price LM. Outcome of intrathecal opioids in chronic non-cancer pain. Eur J Pain. 2001; 5(4): 353-61. PMID: 11743701, PII: S1090-3801(01)90255-1, DOI: 10.1053/eujp.2001.0255, ISSN: 1090-3801.

Montine TJ, Shinobu L, Montine KS, Roberts LJ, Kowall NW, Beal MF, Morrow JD. No difference in plasma or urinary F2-isoprostanes among patients with Huntington's disease or Alzheimer's disease and controls [letter]. Ann. Neurol. 2000 Dec; 48(6): 950. PMID: 11117557, ISSN: 0364-5134.

Roberts LJ, Handman E, Foote SJ. Science, medicine, and the future: Leishmaniasis. BMJ. 2000 Sep 9/30/2000; 321(7264): 801-4. PMID: 11009521, PMCID: PMC1118618, ISSN: 0959-8138.

Finch PM, Roberts LJ, Price L, Hadlow NC, Pullan PT. Hypogonadism in patients treated with intrathecal morphine. Clin J Pain. 2000 Sep; 16(3): 251-4. PMID: 11014399, ISSN: 0749-8047.

Walsh SW, Vaughan JE, Wang Y, Roberts LJ. Placental isoprostane is significantly increased in preeclampsia. FASEB J. 2000 Jul; 14(10): 1289-96. PMID: 10877821, ISSN: 0892-6638.

Roberts LJ, Neal DJ, Kivlahan DR, Baer JS, Marlatt GA. Individual drinking changes following a brief intervention among college students: clinical significance in an indicated preventive context. J Consult Clin Psychol. 2000 Jun; 68(3): 500-5. PMID: 10883566, ISSN: 0022-006X.

O'Byrne S, Forte P, Roberts LJ, Morrow JD, Johnston A, Anggård E, Leslie RD, Benjamin N. Nitric oxide synthesis and isoprostane production in subjects with type 1 diabetes and normal urinary albumin excretion. Diabetes. 2000 May; 49(5): 857-62. PMID: 10905497, ISSN: 0012-1797.

Roberts LJ, Foote SJ, Handman E. A new standard for the assessment of disease progression in murine cutaneous leishmaniasis. Parasite Immunol. 2000 May; 22(5): 231-7. PMID: 10792762, PII: pim305, ISSN: 0141-9838.

Graf BA, Nazarenko DA, Borrello MA, Roberts LJ, Morrow JD, Phipps RP. Proinflammatory signals upregulate COX-2 and increase PGE2 production in biphenotypic B/macrophage cells. Ann. N. Y. Acad. Sci. 2000 Apr; 905: 294-6. PMID: 10818468, ISSN: 0077-8923.

Reich EE, Zackert WE, Brame CJ, Chen Y, Roberts LJ, Hachey DL, Montine TJ, Morrow JD. Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid. Biochemistry. 2000 Mar 3/7/2000; 39(9): 2376-83. PMID: 10694406, PII: bi992000l, ISSN: 0006-2960.

Roberts LJ, Morrow JD. Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo. Free Radic. Biol. Med. 2000 Feb 2/15/2000; 28(4): 505-13. PMID: 10719231, PII: S0891-5849(99)00264-6, ISSN: 0891-5849.

Reckelhoff JF, Zhang H, Srivastava K, Roberts LJ, II, Morrow JD, and Romero JC. Subpressor doses of angiotensin II increase F2-isoprostanes and peroxynitrite in rats. 2000.

Reich EE, Zackert WE, Brame CJ, Chen Y, Roberts LJ, II, Hachey DL, Montine TJ, and Morrow JD. Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid. 2000.

Roberts, LJ, II, and Morrow JD. Measurement of F2-isoprostanes as an index of oxidative stress in vivo. 2000.

O'Byrne, S, Forte, P, Roberts, LJ, II, Morrow, JD, Johnston, A, Angaard. E, Leslie, D, and Benjamin, N. Nitric oxide synthesis and isoprostane production in subjects with Type-1 diabetes and normal urinary albumin excretion. 2000.

Walsh SW, Vaughan JE, Wang Y, and Roberts LJ, II. Placental isoprostane is significantly increased in preeclampsia. 2000.

Hou X, Gobeil F, Peri K, Speranza G., Marrache M, Lachapelle P, Roberts LJ, II, Varma DR, and Chemtob S. Differential induction of vasoconstriction and thromboxane formation in immature pig periventricular brain microvessels by 15-F2t-isoprostane (8-iso-prostaglandin F2 ). 2000.

Phipps RP, Pollock SJ, Kaur K, Kaufman J, Borrello MA, Graf BA, Nazarenko D, Roberts LJ, Morrow JD, Palis J, Ryan DJ, Bennett JM. Expression of cyclooxygenase-2 and prostaglandins by B-1 cells and B-CLL cells. Curr. Top. Microbiol. Immunol. 2000; 252: 293-300. PMID: 11187084, ISSN: 0070-217X.

Reckelhoff JF, Zhang H, Srivastava K, Roberts LJ, Morrow JD, Romero JC. Subpressor doses of angiotensin II increase plasma F(2)-isoprostanes in rats. Hypertension. 2000 Jan; 35(1 Pt 2): 476-9. PMID: 10642344, ISSN: 0194-911X.

Dworski R, Murray JJ, Roberts LJ, Oates JA, Morrow JD, Fisher L, Sheller JR. Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress. Am. J. Respir. Crit. Care Med. 1999 Dec; 160(6): 1947-51. PMID: 10588611, DOI: 10.1164/ajrccm.160.6.9903064, ISSN: 1073-449X.

Roberts LJ, Salem D, Rappaport J, Toro PA, Luke DA, Seidman E. Giving and receiving help: interpersonal transactions in mutual-help meetings and psychosocial adjustment of members. Am J Community Psychol. 1999 Dec; 27(6): 841-68. PMID: 10723537, ISSN: 0091-0562.

Valyi-Nagy T, Sidell KR, Marnett LJ, Roberts LJ, Dermody TS, Morrow JD, Montine TJ. Divergence of brain prostaglandin H synthase activity and oxidative damage in mice with encephalitis. J. Neuropathol. Exp. Neurol. 1999 Dec; 58(12): 1269-75. PMID: 10604752, ISSN: 0022-3069.

Graf BA, Nazarenko DA, Borrello MA, Roberts LJ, Morrow JD, Palis J, Phipps RP. Biphenotypic B/macrophage cells express COX-1 and up-regulate COX-2 expression and prostaglandin E(2) production in response to pro-inflammatory signals. Eur. J. Immunol. 1999 Nov; 29(11): 3793-803. PMID: 10556836, PII: 10.1002/(SICI)1521-4141(199911)29:11<3793::AID-IMMU3793>3.0.CO;2-3, ISSN: 0014-2980.

Montine TJ, Sidell KR, Crews BC, Markesbery WR, Marnett LJ, Roberts LJ, Morrow JD. Elevated CSF prostaglandin E2 levels in patients with probable AD. Neurology. 1999 Oct 10/22/1999; 53(7): 1495-8. PMID: 10534257, ISSN: 0028-3878.

Montine TJ, Markesbery WR, Zackert W, Sanchez SC, Roberts LJ, Morrow JD. The magnitude of brain lipid peroxidation correlates with the extent of degeneration but not with density of neuritic plaques or neurofibrillary tangles or with APOE genotype in Alzheimer's disease patients. Am. J. Pathol. 1999 Sep; 155(3): 863-8. PMID: 10487843, PMCID: PMC1866881, PII: S0002-9440(10)65185-1, DOI: 10.1016/S0002-9440(10)65185-1, ISSN: 0002-9440.

Roberts LJ. Delegation for the novice nurse. Fla Nurse. 1999 Sep; 47(3): 9. PMID: 11995151, ISSN: 0015-4199.

Roberts LJ, Baldwin TM, Speed TP, Handman E, Foote SJ. Chromosomes X, 9, and the H2 locus interact epistatically to control Leishmania major infection. Eur. J. Immunol. 1999 Sep; 29(9): 3047-50. PMID: 10508279, PII: 10.1002/(SICI)1521-4141(199909)29:09<3047::AID-IMMU3047>3.0.CO;2-L, DOI: 10.1002/(SICI)1521-4141(199909)29:09<3047::AID-IMMU3047>3.0.CO;2-L, ISSN: 0014-2980.

Barlow C, Dennery PA, Shigenaga MK, Smith MA, Morrow JD, Roberts LJ, Wynshaw-Boris A, Levine RL. Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs. Proc. Natl. Acad. Sci. U.S.A. 1999 Aug 8/17/1999; 96(17): 9915-9. PMID: 10449794, PMCID: PMC22310, ISSN: 0027-8424.

Mills JL, DerSimonian R, Raymond E, Morrow JD, Roberts LJ, Clemens JD, Hauth JC, Catalano P, Sibai B, Curet LB, Levine RJ. Prostacyclin and thromboxane changes predating clinical onset of preeclampsia: a multicenter prospective study. JAMA. 1999 Jul 7/28/1999; 282(4): 356-62. PMID: 10432033, PII: jci90040, ISSN: 0098-7484.

Boutaud O, Brame CJ, Salomon RG, Roberts LJ, Oates JA. Characterization of the lysyl adducts formed from prostaglandin H2 via the levuglandin pathway. Biochemistry. 1999 Jul 7/20/1999; 38(29): 9389-96. PMID: 10413514, PII: bi990470+, DOI: 10.1021/bi990470+, ISSN: 0006-2960.

Salomon RG, Sha W, Brame C, Kaur K, Subbanagounder G, O'Neil J, Hoff HF, Roberts LJ. Protein adducts of iso[4]levuglandin E2, a product of the isoprostane pathway, in oxidized low density lipoprotein. J. Biol. Chem. 1999 Jul 7/16/1999; 274(29): 20271-80. PMID: 10400646, ISSN: 0021-9258.

Montine TJ, Montine KS, Olson SJ, Graham DG, Roberts LJ, Morrow JD, Linton MF, Fazio S, Swift LL. Increased cerebral cortical lipid peroxidation and abnormal phospholipids in aged homozygous apoE-deficient C57BL/6J mice. Exp. Neurol. 1999 Jul; 158(1): 234-41. PMID: 10448437, PII: S0014-4886(99)97067-X, DOI: 10.1006/exnr.1999.7067, ISSN: 0014-4886.

Morrow JD, Oates JA, Roberts LJ, Zackert WE, Mitchell TA, Lazarus G, Guzzo C. Increased formation of thromboxane in vivo in humans with mastocytosis. J. Invest. Dermatol. 1999 Jul; 113(1): 93-7. PMID: 10417625, PII: jid624, DOI: 10.1046/j.1523-1747.1999.00624.x, ISSN: 0022-202X.

Roberts LJ, Salomon RG, Morrow JD, Brame CJ. New developments in the isoprostane pathway: identification of novel highly reactive gamma-ketoaldehydes (isolevuglandins) and characterization of their protein adducts. FASEB J. 1999 Jul; 13(10): 1157-68. PMID: 10385607, ISSN: 0892-6638.

Liu T, Stern A, Roberts LJ, Morrow JD. The isoprostanes: novel prostaglandin-like products of the free radical-catalyzed peroxidation of arachidonic acid. J. Biomed. Sci. 1999 Jul; 6(4): 226-35. PMID: 10420080, PII: 25391, DOI: 25391, ISSN: 1021-7770.

Jacobson NS, Roberts LJ, Berns SB, McGlinchey JB. Methods for defining and determining the clinical significance of treatment effects: description, application, and alternatives. J Consult Clin Psychol. 1999 Jun; 67(3): 300-7. PMID: 10369050, ISSN: 0022-006X.

Brame CJ, Salomon RG, Morrow JD, Roberts LJ. Identification of extremely reactive gamma-ketoaldehydes (isolevuglandins) as products of the isoprostane pathway and characterization of their lysyl protein adducts. J. Biol. Chem. 1999 May 5/7/1999; 274(19): 13139-46. PMID: 10224068, ISSN: 0021-9258.

Morrow JD, Zackert WE, Yang JP, Kurhts EH, Callewaert D, Dworski R, Kanai K, Taber D, Moore K, Oates JA, Roberts LJ. Quantification of the major urinary metabolite of 15-F2t-isoprostane (8-iso-PGF2alpha) by a stable isotope dilution mass spectrometric assay. Anal. Biochem. 1999 May 5/1/1999; 269(2): 326-31. PMID: 10222005, PII: S0003-2697(99)94008-3, DOI: 10.1006/abio.1999.4008, ISSN: 0003-2697.

Reckelhoff JF, Hennington BS, Kanji V, Racusen LC, Schmidt AM, Yan SD, Morrow J, Roberts LJ, Salahudeen AK. Chronic aminoguanidine attenuates renal dysfunction and injury in aging rats. Am. J. Hypertens. 1999 May; 12(5): 492-8. PMID: 10342787, PII: S0895-7061(98)00264-7, ISSN: 0895-7061.

Choong KY, Roberts LJ. Molluscum contagiosum, swimming and bathing: a clinical analysis. Australas. J. Dermatol. 1999 May; 40(2): 89-92. PMID: 10333619, ISSN: 0004-8380.

Voutilainen S, Morrow JD, Roberts LJ, Alfthan G, Alho H, Nyyssönen K, Salonen JT. Enhanced in vivo lipid peroxidation at elevated plasma total homocysteine levels. Arterioscler. Thromb. Vasc. Biol. 1999 May; 19(5): 1263-6. PMID: 10323778, ISSN: 1079-5642.

Chen Y, Morrow JD, Roberts LJ. Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway. J. Biol. Chem. 1999 Apr 4/16/1999; 274(16): 10863-8. PMID: 10196163, ISSN: 0021-9258.

Holt S, Reeder B, Wilson M, Harvey S, Morrow JD, Roberts LJ, Moore K. Increased lipid peroxidation in patients with rhabdomyolysis [letter]. Lancet. 1999 Apr 4/10/1999; 353(9160): 1241. PMID: 10217088, PII: S0140-6736(98)05768-7, DOI: 10.1016/S0140-6736(98)05768-7, ISSN: 0140-6736.

Montine TJ, Beal MF, Robertson D, Cudkowicz ME, Biaggioni I, O'Donnell H, Zackert WE, Roberts LJ, Morrow JD. Cerebrospinal fluid F2-isoprostanes are elevated in Huntington's disease. Neurology. 1999 Mar 3/23/1999; 52(5): 1104-5. PMID: 10102447, ISSN: 0028-3878.

van der Veen RC, Roberts LJ. Contrasting roles for nitric oxide and peroxynitrite in the peroxidation of myelin lipids. J. Neuroimmunol. 1999 Mar 3/1/1999; 95(1-2): 1-7. PMID: 10229110, ISSN: 0165-5728.

Morrow JD, Chen Y, Brame CJ, Yang J, Sanchez SC, Xu J, Zackert WE, Awad JA, Roberts LJ. The isoprostanes: unique prostaglandin-like products of free-radical-initiated lipid peroxidation. Drug Metab. Rev. 1999 Feb; 31(1): 117-39. PMID: 10065368, DOI: 10.1081/DMR-100101910, ISSN: 0360-2532.

Montine TJ, Beal MF, Cudkowicz ME, O'Donnell H, Margolin RA, McFarland L, Bachrach AF, Zackert WE, Roberts LJ, Morrow JD. Increased CSF F2-isoprostane concentration in probable AD. Neurology. 1999 Feb; 52(3): 562-5. PMID: 10025788, ISSN: 0028-3878.

Chen Y, Zackert WE, Roberts LJ, Morrow JD. Evidence for the formation of a novel cyclopentenone isoprostane, 15-A2t-isoprostane (8-iso-prostaglandin A2) in vivo. Biochim. Biophys. Acta. 1999 Jan 1/4/1999; 1436(3): 550-6. PMID: 9989284, PII: S0005-2760(98)00168-4, ISSN: 0006-3002.

Roberts, LJ, II, Brame, CJ, Chen, Y, and Morrow, JD. Novel eicosanoids: Isoprostanes and related compounds. 1999.

Roberts, LJ, II, and Morrow, JD. Isoprostanes as markers of lipid peroxidation in atherosclerosis. 1999.

Roberts, LJ, II, and Morrow, JD. Formation of novel isoprostane-like compounds by free radical catalyzed peroxidation of docosahexaenoic acid. 1999.

Morrow, JD, Chen, Y, Brame, CJ, Yang, J, Sanchez, SC, Xu, J, Zackert, WE, and Roberts, LJ, II. The isoprostanes: Unique prostaglandin-like products of free radical-catalyzed lipid peroxidation. 1999.

Montine, TJ, Beal, MF, Cudkowicz, MD, O'Donnel, H, Margolin, RA, McFarland, L., Cachrach, AF, Zackert, WE, Roberts, LJ, II, and Morrow, JD. Increased CSF F2-isoprostane concentration in probable AD. 1999.

Holt, S, Reeder, B, Wilson, M, Harvey, S, Morrow, JD, Roberts, LJ, II, and Moore, K. Increased lipid peroxidation in patients with rhabdomyolysis. 1999.

Montine, TJ, Beal, MF, Roberts, D, Cudkowicz, ME, Brown, RH, O'Donnel, H, Zackert, WE, Roberts, LJ, II, and Morrow, JD. Cerebrospinal levels of F2-isoprostanes, specific markers of lipid peroxidation, are elevated in Huntington's disease patients. 1999.

Morrow JD, Zackert WE, Yang JP, Kurhts EH, Callewaert D, Kanai, K, Taber DF, Moore, KP, Oates JA, and Roberts LJ II. Quantification of the major urinary metabolite of the isoprostane 15-F2t-isoprostane (8-iso-PGF2 ) by stable isotope dilution mass spectrometric assay. 1999.

Chen Y, Zackert WE, Roberts LJ II, and Morrow JD. Evidence for the formation of a novel cyclopentenone isoprostane, 15-A2t-IsoP (8-iso-prostaglandin A2. 1999.

Reckelhof JF, Henntington, BS, Kanjii V, Racusen LC, Schmidt SD, Yan J, Morrow JD, Roberts LJ II, and Salahudeen AK. Chronic aminoguanidine attenuates renal dysfunction and injury in aging rats. 1999.

Voutilainen S, Morrow, JD, Roberts, LJ, II, Alfthan, G, Alho, H, Nyyssonen, K, and Salonen, JT. Enhanced in vivo lipid peoxidation at elevated plasma homocysteine levels. 1999.

Boutand, O, Brame, CJ, Salomon, RG, Roberts, LJ, II, and Oates, JA. Characterization of lysyl adducts formed from prostaglandin H2 via the levuglandin pathway. 1999.

Salomon, RG, Sha W, Brame, C, Kaur, K, Subbanagounder, G, O'Neil, J, Hoff, HF, and Roberts, LJ, II. Protein adducts of isolevuglandin E2 in oxidized low density lipoprotein. 1999.

Montine, TJ, Montine, KS, Olson, SJ, Graham, DG, Roberts, LJ, II, Morrow, JD, Swift, LL, Linton, M, and Fazio, S. Increased cerebral cortical products of lipid peroxidation (Neuroprostanes) and abnormal phospholipids in aged homozygous ApoE deficient C57BL/Cj mice. 1999.

Montine, TJ, Sidell, KR, Crews, BC, Zackert, WE, Markesbery, WR, Marnett, Roberts, LJ, II, and Morrow, JD. Elevated CSF prostaglandin E2 levels in patients with probable AD. 1999.

Liu T, Stern A, Roberts LJ, II, and Morrow JD. The isoprostanes: novel prostaglandin-like products of the free radical-catalyzed peroxidation of arachidonic acid. 1999.

Barlow C, Dennery PA, Shigenaga MK, Smith MA, Morrow JD, Roberts LJ, II, Wynshaw-Boris A, and Levine RL. Loss of the ataxia-telangiectasia gene products causes oxidative damage in target organs. 1999.

Montine TJ, Markesbery WR, Zackert W, Sanchez SC, Roberts LJ, II, and Morrow JD. The magnitude of brain lipid peroxidation correlates with the extent of degeneration but not with density of neuritic plaques or neurofibrillary tangles or with APE Genotype in Alzheimer's disease patients. 1999.

Valyi-Nagy, T, Sidell, KR, Marnett, LJ, Roberts, LJ, II, Dermody, TS, Morrow, JD, and Montine, TJ. Divergence of brain prostaglandin H synthase activity and oxidative damage in mice with encephalitis. 1999.

Dworski R, Murray JJ, Roberts, LJ, II, Oates, JA, Morrow, JD, Fisher, L., and Sheller, JR. Allergen-induced synthesis of F2-isoprostanes in atopic asthmatics: evidence for oxidative stress. 1999.

Chen, Y, Morrow, JD, and Roberts, LJ, II. Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway. 1999.

Salahudeen A, Nawaz M, Poovala V, Kanjii V, Wang C, Morrow JD, and Roberts LJ II. Cold induces time-dependent F2-isoprostane formation in renal tubular cells and rat kidneys stored in University of Wisconsin solution: Implications for immediate post-transplant renal vasoconstriction. 1999.

Van der Veen, R, and Roberts, LJ, II. Contrasting roles for nitric oxide and peroxynitrite in the peroxidation of myelin lipids. 1999.

Roberts, LJ, II, Salomon, RG, Morrow, JD, and Brame, CJ. New developments in the isoprostane pathway: Identification of novel highly reactive -ketoaldehydes (isolevuglandins) and characterization of their protein adducts. 1999.

Morrow JD, Tapper AR, Zackert WE, Yang J, Sanchez SC, Montine TJ, Roberts LJ. Formation of novel isoprostane-like compounds from docosahexaenoic acid. Adv. Exp. Med. Biol. 1999; 469: 343-7. PMID: 10667351, ISSN: 0065-2598.

Roberts LJ, Brame CJ, Chen Y, Morrow JD, Salomon RG. Formation of reactive products of the isoprostane pathway: isolevuglandins and cyclopentenone isoprostanes. Adv. Exp. Med. Biol. 1999; 469: 335-41. PMID: 10667350, ISSN: 0065-2598.

Roberts LJ, Brame CJ, Chen Y, Morrow JD. Novel eicosanoids. Isoprostanes and related compounds. Methods Mol. Biol. 1999; 120: 257-85. PMID: 10343322, DOI: 10.1385/1-59259-263-5:257, ISSN: 1064-3745.

Morrow JD, Roberts LJ. Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress. Meth. Enzymol. 1999; 300: 3-12. PMID: 9919502, PII: S0076-6879(99)00106-8, ISSN: 0076-6879.

Kadiiska MB, Morrow JD, Awad JA, Roberts LJ, Mason RP. Identification of free radical formation and F2-isoprostanes in vivo by acute Cr(VI) poisoning. Chem. Res. Toxicol. 1998 Dec; 11(12): 1516-20. PMID: 9860496, PII: tx980169e, DOI: 10.1021/tx980169e, ISSN: 0893-228X.

Moore KP, Holt SG, Patel RP, Svistunenko DA, Zackert W, Goodier D, Reeder BJ, Clozel M, Anand R, Cooper CE, Morrow JD, Wilson MT, Darley-Usmar V, Roberts LJ. A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure. J. Biol. Chem. 1998 Nov 11/27/1998; 273(48): 31731-7. PMID: 9822635, ISSN: 0021-9258.

Leonard KE, Roberts LJ. The effects of alcohol on the marital interactions of aggressive and nonaggressive husbands and their wives. J Abnorm Psychol. 1998 Nov; 107(4): 602-15. PMID: 9830248, ISSN: 0021-843X.

Montine TJ, Markesbery WR, Morrow JD, Roberts LJ. Cerebrospinal fluid F2-isoprostane levels are increased in Alzheimer's disease. Ann. Neurol. 1998 Sep; 44(3): 410-3. PMID: 9749613, DOI: 10.1002/ana.410440322, ISSN: 0364-5134.

Morrow JD, Scruggs J, Chen Y, Zackert WE, Roberts LJ. Evidence that the E2-isoprostane, 15-E2t-isoprostane (8-iso-prostaglandin E2) is formed in vivo. J. Lipid Res. 1998 Aug; 39(8): 1589-93. PMID: 9717718, ISSN: 0022-2275.

Moore K, Roberts LJ. Measurement of lipid peroxidation. Free Radic. Res. 1998 Jun; 28(6): 659-71. PMID: 9736317, ISSN: 1071-5762.

Salahudeen AK, Reckelhoff JF, Morrow JD, Roberts LJ. F2-isoprostanes and the kidney. Drug News Perspect. 1998 Jun; 11(5): 287-90. PMID: 15616648, PII: 38, ISSN: 0214-0934.

Roberts LJ, Montine TJ, Markesbery WR, Tapper AR, Hardy P, Chemtob S, Dettbarn WD, Morrow JD. Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid. J. Biol. Chem. 1998 May 5/29/1998; 273(22): 13605-12. PMID: 9593698, ISSN: 0021-9258.

Bolton PG, Mira M, Roberts LJ, Usher HE. Is health care card status related to consultation time? [letter]. Med. J. Aust. 1998 May 5/18/1998; 168(10): 527-8. PMID: 9631687, ISSN: 0025-729X.

Morrow JD, Roberts LJ, Daniel VC, Awad JA, Mirochnitchenko O, Swift LL, Burk RF. Comparison of formation of D2/E2-isoprostanes and F2-isoprostanes in vitro and in vivo--effects of oxygen tension and glutathione. Arch. Biochem. Biophys. 1998 May 5/1/1998; 353(1): 160-71. PMID: 9578611, PII: S0003-9861(98)90645-2, DOI: 10.1006/abbi.1998.0645, ISSN: 0003-9861.

Lahaie I, Hardy P, Hou X, Hasséssian H, Asselin P, Lachapelle P, Almazan G, Varma DR, Morrow JD, Roberts LJ, Chemtob S. A novel mechanism for vasoconstrictor action of 8-isoprostaglandin F2 alpha on retinal vessels. Am. J. Physiol. 1998 May; 274(5 Pt 2): R1406-16. PMID: 9612409, ISSN: 0002-9513.

Shaner A, Roberts LJ, Eckman TA, Racenstein JM, Tucker DE, Tsuang JW, Mintz J. Sources of diagnostic uncertainty for chronically psychotic cocaine abusers. Psychiatr Serv. 1998 May; 49(5): 684-90. PMID: 9603577, DOI: 10.1176/ps.49.5.684, ISSN: 1075-2730.

Reckelhoff JF, Kanji V, Racusen LC, Schmidt AM, Yan SD, Marrow J, Roberts LJ, Salahudeen AK. Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys. Am. J. Physiol. 1998 Mar; 274(3 Pt 2): R767-74. PMID: 9530244, ISSN: 0002-9513.

Roberts, LJ, II, Montine, TJ, Markesbery, WR, Tapper, AR, Hardy P, Chemtob, C, Dettbarn, WD, and Morrow, JD.. Formation of isoprostane- like compounds (Neuroprostanes) in vivo from docosahexaenoic acid. 1998.

Morrow, JD, Roberts, LJ, II, Daniel, VC, Mirotchnechenko, O, Swift, L., and Burk, RF. Comparison of the formation of D2/E2-Isoprostanes to F2-isoprostanes in vitro and in vivo: Effect of oxygen tension and glutathione. 1998.

Morrow, JD, Scruggs, J, Chen, Y, Zackert, WE, and Roberts, LJ, II. Evidence that the E2-isoprostane, 15-E2t-isoprostane (8-isoprostaglandin E2) is formed in vivo. 1998.

Lahaie, I, Hardy, P, Hou, X, Hassessian, H, Asselin, P, Lachapelle, P, Almazan, G, Varma, DR, Morrow, J.D, Roberts, LJ, II, and Chemtob, S. A novel mechanism for the vasoconstrictor action of 8-iso-prostaglandin F2 on retinal blood vessels. Am. J. Physiol.274 (Regulatory Integrative Comp. 1998.

Morrow, JD, and Roberts, LJ, II. Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as a measure of oxidant stress. 1998.

Kanji, V, Racusen L, Schmidt, AM, Yan, SD, Morrow, JD, Roberts, LJ, II, and Salahudeen, AK. Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys. 1998.

Salahudeen, AK, Reckelhoff, JF, Morrow, JD, and Roberts, LJ, II. F2- isoprostanes and the kidney. 1998.

Morrow, JD, Chen, Y, Zackert, WE, and Roberts, LJ, II. The isoprostanes: recent advances. 1998.

Montine, TJ, Markesbery, WR, Morrow, JD, and Roberts, LJ, II. Cerebrospinal fluid F2-isoprostane levels are increased in patients with Alzheimer's disease. 1998.

Moore, K, and Roberts, LJ, II. Measurement of lipid peroxidation. 1998.

Kadiiska, MB, Morrow, JD, Awad, JA, Roberts, LJ, II, and Mason, RP. Enhanced formation of free radicals and F2-isoprostanes in vivo by acute Cr (VI) poisoning. 1998.

Moore K, Patel, R, Darley-Usmar, V, Holt, S, Zackert WE, Clozel, M, Anand, R, Wilson, M, Harvey, S, Morrow, JD, and Roberts, LJ, II. A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure. 1998.

Salahudeen, A, Wilson, P, Pande, R, Poovala, V, Kanji, V, Ansari, N, Morrow, JD, and Roberts, LJ, II. Cisplatin induces N-acetyl cysteine suppressible F2-isoprostane production and injury in renal tubular epithelial cells. 1998.

Barrett RS, Neal RJ, Roberts LJ. The dynamic loading response of surfaces encountered in beach running. J Sci Med Sport. 1998 Jan; 1(1): 1-11. PMID: 9732116, ISSN: 1440-2440.

Melanson M, Nalbantoglu J, Berkovic S, Melmed C, Andermann E, Roberts LJ, Carpenter S, Snipes GJ, Andermann F. Progressive myoclonus epilepsy in young adults with neuropathologic features of Alzheimer's disease. Neurology. 1997 Dec; 49(6): 1732-3. PMID: 9409382, ISSN: 0028-3878.

Gniwotta C, Morrow JD, Roberts LJ, Kühn H. Prostaglandin F2-like compounds, F2-isoprostanes, are present in increased amounts in human atherosclerotic lesions. Arterioscler. Thromb. Vasc. Biol. 1997 Nov; 17(11): 3236-41. PMID: 9409317, ISSN: 1079-5642.

Lynch SM, Frei B, Morrow JD, Roberts LJ, Xu A, Jackson T, Reyna R, Klevay LM, Vita JA, Keaney JF. Vascular superoxide dismutase deficiency impairs endothelial vasodilator function through direct inactivation of nitric oxide and increased lipid peroxidation. Arterioscler. Thromb. Vasc. Biol. 1997 Nov; 17(11): 2975-81. PMID: 9409284, ISSN: 1079-5642.

Garabedian EM, Roberts LJ, McNevin MS, Gordon JI. Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice. J. Biol. Chem. 1997 Sep 9/19/1997; 272(38): 23729-40. PMID: 9295317, ISSN: 0021-9258.

Berger TM, Polidori MC, Dabbagh A, Evans PJ, Halliwell B, Morrow JD, Roberts LJ, Frei B. Antioxidant activity of vitamin C in iron-overloaded human plasma. J. Biol. Chem. 1997 Jun 6/20/1997; 272(25): 15656-60. PMID: 9188455, ISSN: 0021-9258.

Shaner A, Roberts LJ, Eckman TA, Tucker DE, Tsuang JW, Wilkins JN, Mintz J. Monetary reinforcement of abstinence from cocaine among mentally ill patients with cocaine dependence. Psychiatr Serv. 1997 Jun; 48(6): 807-10. PMID: 9175190, DOI: 10.1176/ps.48.6.807, ISSN: 1075-2730.

Soliman MS, Cunningham ML, Morrow JD, Roberts LJ, Badr MZ. Evidence against peroxisome proliferation-induced hepatic oxidative damage. Biochem. Pharmacol. 1997 May 5/9/1997; 53(9): 1369-74. PMID: 9214698, PII: S0006295297879567, ISSN: 0006-2952.

Roberts LJ, Baldwin TM, Curtis JM, Handman E, Foote SJ. Resistance to Leishmania major is linked to the H2 region on chromosome 17 and to chromosome 9. J. Exp. Med. 1997 May 5/5/1997; 185(9): 1705-10. PMID: 9151907, PMCID: PMC2196292, ISSN: 0022-1007.

Roberts LJ, Morrow JD. The generation and actions of isoprostanes. Biochim. Biophys. Acta. 1997 Apr 4/1/1997; 1345(2): 121-35. PMID: 9106492, ISSN: 0006-3002.

Morrow JD, Roberts LJ. The isoprostanes: unique bioactive products of lipid peroxidation. Prog. Lipid Res. 1997 Mar; 36(1): 1-21. PMID: 9373618, PII: S0163782797000015, ISSN: 0163-7827.

Taber DF, Morrow JD, Roberts LJ. A nomenclature system for the isoprostanes. Prostaglandins. 1997 Feb; 53(2): 63-7. PMID: 9112285, PII: S0090698097000051, ISSN: 0090-6980.

Roberts, LJ, II, and Morrow, JD. Generation and actions of isoprostanes. 1997.

Taber, DF, Morrow, JD, and Roberts, LJ, II. A nomenclature system for the isoprostanes. 1997.

Berger, TM, Polidori, MC, Dabbagh, A, Evans, PJ, Halliwell, B, Morrow, JD, and Roberts, LJ, II, Avery, ME, and Frei, B. Antioxidant activity of vitamin C in iron-overloaded human plasma. 1997.

Soliman MS, Cunningham ML, Morrow JD, Roberts LJ, II, and Badr MZ. Evidence against peroxisome proliferation-induced hepatic oxidative damage. 1997.

Morrow, JD, and Roberts, LJ, II. The isoprostanes: unique bioactive products of lipid peroxidation. 1997.

Waugh RJ, Morrow, JD, Roberts, LJ, II, and Murphy RC. Identification and relative quantitation of F2-isoprostane regioisomers formed in vivo in the rat. 1997.

Gniwotta, C, Morrow, JD, Roberts, LJ, II, and Kuhn, H. Prostaglandin F2-like compounds, F2-isoprostanes, are present in increased amounts in human atherosclerotic lesions. 1997.

Lynch, SM, Frei, B, Morrow, JD, Roberts, LJ, II, Xu, A, Jackson, T, Reyna, R, Klevay, LM, Vita, JA, and Keaney, JF, Jr. Vascular superoxide dismutase deficiency impairs endothelial vasodilator function through direct inactivation of nitric oxide and increased lipid peroxidation. 1997.

Smith CJ, Morrow JD, Roberts LJ, Marnett LJ. Induction of prostaglandin endoperoxide synthase-1 (COX-1) in a human promonocytic cell line by treatment with the differentiating agent TPA. Adv. Exp. Med. Biol. 1997; 400A: 99-106. PMID: 9547543, ISSN: 0065-2598.

Waugh RJ, Morrow JD, Roberts LJ, Murphy RC. Identification and relative quantitation of F2-isoprostane regioisomers formed in vivo in the rat. Free Radic. Biol. Med. 1997; 23(6): 943-54. PMID: 9378374, PII: S0891-5849(97)00133-0, ISSN: 0891-5849.

DuBois R, Tsujii M, Morrow J, Awad J, Roberts L, Bishop P. Eicosanoid production and growth regulation in rat intestinal epithelial cells. Adv. Exp. Med. Biol. 1997; 400A: 487-93. PMID: 9547594, ISSN: 0065-2598.

Kleger GR, Bärtsch P, Vock P, Heilig B, Roberts LJ, Ballmer PE. Evidence against an increase in capillary permeability in subjects exposed to high altitude. J. Appl. Physiol. 1996 Nov; 81(5): 1917-23. PMID: 8941510, ISSN: 8750-7587.

Roberts LJ. Knowledge and use of periconceptual folic acid supplements by British Forces Germany personnel and dependents. J R Army Med Corps. 1996 Oct; 142(3): 116-9. PMID: 8933472, ISSN: 0035-8665.

Itoh S, Lu R, Bao Y, Morrow JD, Roberts LJ, Schuster VL. Structural determinants of substrates for the prostaglandin transporter PGT. Mol. Pharmacol. 1996 Oct; 50(4): 738-42. PMID: 8863817, ISSN: 0026-895X.

Morrow JD, Awad JA, Wu A, Zackert WE, Daniel VC, Roberts LJ. Nonenzymatic free radical-catalyzed generation of thromboxane-like compounds (isothromboxanes) in vivo. J. Biol. Chem. 1996 Sep 9/20/1996; 271(38): 23185-90. PMID: 8798513, ISSN: 0021-9258.

Roberts LJ, Moore KP, Zackert WE, Oates JA, Morrow JD. Identification of the major urinary metabolite of the F2-isoprostane 8-iso-prostaglandin F2alpha in humans. J. Biol. Chem. 1996 Aug 8/23/1996; 271(34): 20617-20. PMID: 8702808, ISSN: 0021-9258.

Yang ZP, Morrow J, Wu A, Roberts LJ, Dettbarn WD. Diisopropylphosphorofluoridate-induced muscle hyperactivity associated with enhanced lipid peroxidation in vivo. Biochem. Pharmacol. 1996 Jul 7/26/1996; 52(2): 357-61. PMID: 8694861, PII: 0006-2952(96)00214-6, ISSN: 0006-2952.

Stein CM, Tanner SB, Awad JA, Roberts LJ, Morrow JD. Evidence of free radical-mediated injury (isoprostane overproduction) in scleroderma. Arthritis Rheum. 1996 Jul; 39(7): 1146-50. PMID: 8670323, ISSN: 0004-3591.

Awas JA, Soteriou MC, Drougas JG, Stokes KA, Roberts LJ, Pinson CW. Plasma prostaglandin E1 concentrations and hemodynamics during intravenous infusions of prostaglandin E1 in humans and swine. Transplantation. 1996 Jun 6/15/1996; 61(11): 1624-9. PMID: 8669108, ISSN: 0041-1337.

Awad JA, Roberts LJ, Burk RF, Morrow JD. Isoprostanes--prostaglandin-like compounds formed in vivo independently of cyclooxygenase: use as clinical indicators of oxidant damage. Gastroenterol. Clin. North Am. 1996 Jun; 25(2): 409-27. PMID: 9229581, ISSN: 0889-8553.

Awad JA, Horn JL, Roberts LJ, Franks JJ. Demonstration of halothane-induced hepatic lipid peroxidation in rats by quantification of F2-isoprostanes. Anesthesiology. 1996 Apr; 84(4): 910-6. PMID: 8638846, ISSN: 0003-3022.

Choong KY, Roberts LJ. Ritual Samoan body tattooing and associated sporotrichosis. Australas. J. Dermatol. 1996 Feb; 37(1): 50-3. PMID: 8936073, ISSN: 0004-8380.

Morrow JD, Roberts LJ. The isoprostanes. Current knowledge and directions for future research. Biochem. Pharmacol. 1996 Jan 1/12/1996; 51(1): 1-9. PMID: 8534261, PII: 0006295295020721, ISSN: 0006-2952.

Morrow, JD, and Roberts, LJ, II. The isoprostanes: current knowledge and directions for future research. 1996.

Awad, JA, Horn, J-L, Roberts, LJ, II, and Franks, JJ. Demonstration of halothane-induced hepatic lipid peroxidation in rats using F2-isoprostanes. 1996.

Awad, JA, Roberts, LJ, II, Burk, RA, Morrow, JD. Isoprostanes, prostaglandin-like compounds formed in vivo independently of the cyclooxygenase: Use as clinical indicator of oxidant damage. 1996.

Roberts, L J, II, Moore, KP, Zackert, WE, Oates, JA, and Morrow, JD. Identification of the major urinary metabolite of the F2-isoprostane, 8-iso-prostaglandin F2 , in humans. 1996.

Stein, CM, Awad, JA, Tanner, SB, Roberts, LJ, II, and Morrow, JD. Evidence for free radical mediated injury (isoprostane overproduction) in scleroderma. 1996.

Morrow, JD, and Roberts, LJ, II. Measurement of F2-isoprostanes: prostaglandin-like products of lipid peroxidation. 1996.

Morrow, JD, Awad, JA, Wu, A., Zackert, WE, Daniel, VC, and Roberts, LJ, II. Free radical-induced generation of thromboxane-like compounds (isothromboxanes) in vivo. 1996.

Yang, ZP, Wu, A, Morrow, JD, Roberts, LJ, II, and Dettbarn, W-D. Increases in malondialdehyde-thiobarbituric acid complex (MDA-TBA) and F2-isoprostanes in diisopropyl fluorophosphate induced muscle hyperactivity. 1996.

Itoh, S, Morrow, JD, Roberts, LJ, II, and Schuster, VL. Structural determinants of substrates for the prostaglandin transporter "PGT". 1996.

Bartsch, P, Vock, P, Roberts, LJ, II, and Ballmer, PE. Evidence against a dominant role for increased capillary permeability in the development of acute mountain sickness and high altitude pulmonary edema. 1996.

Awad J, Morrow J, Roberts LJ. Comments on prostaglandin F2 alpha rises in response to hydroxyl radical generated in vivo [letter]. Free Radic. Biol. Med. 1995 Dec; 19(6): 944-6. PMID: 8582673, PII: 089158499594364J, ISSN: 0891-5849.

Rangachari PK, Betti PA, Prior ET, Roberts LJ. Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW A868C) on the canine colonic epithelium: an argument for a different DP receptor?. J. Pharmacol. Exp. Ther. 1995 Nov; 275(2): 611-7. PMID: 7473146, ISSN: 0022-3565.

Murray JJ, Mullins MD, Knapp HR, Keller SL, Serafin WE, Roberts LJ, Struthers BJ, Oates JA. Regulation of the Immune Response by Eicosanoids: Pharmacology and Clinical Effects of Prostaglandin E in Aspirin-Sensitive Syndromes. Am J Ther. 1995 Oct; 2(10): 739-48. PMID: 11854780, ISSN: 1536-3686.

Shaner A, Eckman TA, Roberts LJ, Wilkins JN, Tucker DE, Tsuang JW, Mintz J. Disability income, cocaine use, and repeated hospitalization among schizophrenic cocaine abusers--a government-sponsored revolving door?. N. Engl. J. Med. 1995 Sep 9/21/1995; 333(12): 777-83. PMID: 7643886, DOI: 10.1056/NEJM199509213331207, ISSN: 0028-4793.

Simon TC, Roberts LJ, Gordon JI. A 20-nucleotide element in the intestinal fatty acid binding protein gene modulates its cell lineage-specific, differentiation-dependent, and cephalocaudal patterns of expression in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 1995 Sep 9/12/1995; 92(19): 8685-9. PMID: 7567997, PMCID: PMC41031, ISSN: 0027-8424.

Moore KP, Darley-Usmar V, Morrow J, Roberts LJ. Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite. Circ. Res. 1995 Aug; 77(2): 335-41. PMID: 7614720, ISSN: 0009-7330.

Morrow JD, Guzzo C, Lazarus G, Oates JA, Roberts LJ. Improved diagnosis of mastocytosis by measurement of the major urinary metabolite of prostaglandin D2. J. Invest. Dermatol. 1995 Jun; 104(6): 937-40. PMID: 7769262, PII: 0022202X9500067U, ISSN: 0022-202X.

Morrow JD, Frei B, Longmire AW, Gaziano JM, Lynch SM, Shyr Y, Strauss WE, Oates JA, Roberts LJ. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. N. Engl. J. Med. 1995 May 5/4/1995; 332(18): 1198-203. PMID: 7700313, DOI: 10.1056/NEJM199505043321804, ISSN: 0028-4793.

Bewley S, Roberts LJ, Mackinson AM, Rodeck CH. First trimester fetal nuchal translucency: problems with screening the general population. 2. Br J Obstet Gynaecol. 1995 May; 102(5): 386-8. PMID: 7612532, ISSN: 0306-5456.

Roberts LJ, Bewley S, Mackinson AM, Rodeck CH. First trimester fetal nuchal translucency: problems with screening the general population. 1. Br J Obstet Gynaecol. 1995 May; 102(5): 381-5. PMID: 7612531, ISSN: 0306-5456.

Downard CD, Roberts LJ, Morrow JD. Topical benzoic acid induces the increased biosynthesis of prostaglandin D2 in human skin in vivo. Clin. Pharmacol. Ther. 1995 Apr; 57(4): 441-5. PMID: 7712673, PII: 0009-9236(95)90214-7, DOI: 10.1016/0009-9236(95)90214-7, ISSN: 0009-9236.

Morrow, JD, Frei, B, Longmire, AW, Gaziano, JM, Lynch, SM, Strauss, WE, Oates, JA, Roberts, LJ, II. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers: Smoking as a cause of oxidative damage. 1995.

Moore, KP, Darley-Usmar, V, Morrow JD, and Roberts, LJ, II. Formation of F2-isoprostanes during the oxidation of human low density lipoprotein and plasma by peroxynitrite. 1995.

Salahucleen, A, Bach, K, Morrow, JD, and Roberts, LJ, II. Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells. 1995.

Roberts LJ, Morrow JD. The isoprostanes: novel markers of lipid peroxidation and potential mediators of oxidant injury. Adv. Prostaglandin Thromboxane Leukot. Res. 1995; 23: 219-24. PMID: 7732838, ISSN: 0732-8141.

Moore KP, Darley-Usmar V, Morrow J, Roberts LJ. Formation of F2-isoprostanes during the oxidation of human low density lipoprotein by peroxynitrite. Adv. Prostaglandin Thromboxane Leukot. Res. 1995; 23: 225-7. PMID: 7732839, ISSN: 0732-8141.

Roberts LJ, Morrow JD. Isoprostanes. Novel markers of endogenous lipid peroxidation and potential mediators of oxidant injury. Ann. N. Y. Acad. Sci. 1994 Nov 11/15/1994; 744: 237-42. PMID: 7825845, ISSN: 0077-8923.

Nassar GM, Morrow JD, Roberts LJ, Lakkis FG, Badr KF. Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes. J. Biol. Chem. 1994 Nov 11/4/1994; 269(44): 27631-4. PMID: 7961680, ISSN: 0021-9258.

Morrow JD, Minton TA, Awad JA, Roberts LJ. Release of markedly increased quantities of prostaglandin D2 from the skin in vivo in humans following the application of sorbic acid. Arch Dermatol. 1994 Nov; 130(11): 1408-12. PMID: 7979442, ISSN: 0003-987X.

Longmire AW, Roberts LJ, Morrow JD. Actions of the E2-isoprostane, 8-ISO-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: additional evidence for the existence of a unique isoprostane receptor. Prostaglandins. 1994 Oct; 48(4): 247-56. PMID: 7878192, ISSN: 0090-6980.

Awad JA, Burk RF, Roberts LJ. Effect of selenium deficiency and glutathione-modulating agents on diquat toxicity and lipid peroxidation in rats. J. Pharmacol. Exp. Ther. 1994 Sep; 270(3): 858-64. PMID: 7932197, ISSN: 0022-3565.

Stein CM, Longmire AW, Minton TA, Roberts LJ, Pincus T, Morrow JD. Cyclosporine-induced alterations in renal function are not associated with lipid peroxidation. Transplantation. 1994 Aug 8/15/1994; 58(3): 386-8. PMID: 8053066, ISSN: 0041-1337.

Rodeck CH, Roberts LJ. Successful treatment of fetal cardiac arrest by left ventricular exchange transfusion. Fetal. Diagn. Ther. 1994 Jul; 9(4): 213-7. PMID: 7945899, ISSN: 1015-3837.

Awad JA, Morrow JD, Hill KE, Roberts LJ, Burk RF. Detection and localization of lipid peroxidation in selenium- and vitamin E-deficient rats using F2-isoprostanes. J. Nutr. 1994 Jun; 124(6): 810-6. PMID: 8207538, ISSN: 0022-3166.

Awad JA, Morrow JD, Roberts LJ. Detection of the major urinary metabolite of prostaglandin D2 in the circulation: demonstration of elevated levels in patients with disorders of systemic mast cell activation. J. Allergy Clin. Immunol. 1994 May; 93(5): 817-24. PMID: 8182221, PII: 0091-6749(94)90371-9, ISSN: 0091-6749.

Longmire AW, Swift LL, Roberts LJ, Awad JA, Burk RF, Morrow JD. Effect of oxygen tension on the generation of F2-isoprostanes and malondialdehyde in peroxidizing rat liver microsomes. Biochem. Pharmacol. 1994 Mar 3/29/1994; 47(7): 1173-7. PMID: 8161346, ISSN: 0006-2952.

Lynch SM, Morrow JD, Roberts LJ, Frei B. Formation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro. J. Clin. Invest. 1994 Mar; 93(3): 998-1004. PMID: 8132786, PMCID: PMC294019, DOI: 10.1172/JCI117107, ISSN: 0021-9738.

Morrow JD, Minton TA, Mukundan CR, Campbell MD, Zackert WE, Daniel VC, Badr KF, Blair IA, Roberts LJ. Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes. J. Biol. Chem. 1994 Feb 2/11/1994; 269(6): 4317-26. PMID: 8307999, ISSN: 0021-9258.

DuBois RN, Awad J, Morrow J, Roberts LJ, Bishop PR. Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester. J. Clin. Invest. 1994 Feb; 93(2): 493-8. PMID: 8113389, PMCID: PMC293869, DOI: 10.1172/JCI116998, ISSN: 0021-9738.

Roberts LJ, Beardsworth SA, Trew G. Labour following caesarean section: current practice in the United Kingdom. Br J Obstet Gynaecol. 1994 Feb; 101(2): 153-5. PMID: 8305391, ISSN: 0306-5456.

Morrow JD, Minton TA, Badr KF, Roberts LJ. Evidence that the F2-isoprostane, 8-epi-prostaglandin F2 alpha, is formed in vivo. Biochim. Biophys. Acta. 1994 Jan 1/3/1994; 1210(2): 244-8. PMID: 8280777, PII: 0005-2760(94)90128-7, ISSN: 0006-3002.

Morrow, JD, Badr, KF, and Roberts, LJ, II. Evidence that the F2-isoprostane, 8-epi-PGF2 , is formed in vivo. 1994.

Morrow, JD, Minton, TA, Mukundan, CR, Campbell, MD, Zackert, WE, Daniel, VC. Badr, KF, Blair, IA, and Roberts, LJ, II. Free radical induced generation of isoprostanes in vivo: Evidence for the formation of D-ring and E-ring isoprostanes. 1994.

Lynch, SM, Morrow, JD, Roberts, LJ, II, and Frei, B. Formation of non-cyclooxygenase derived prostanoids (F2-isoprostanes) in human plasma and isolated low density lipoproteins exposed to metal ion-dependent and -independent oxidative stress. 1994.

Morrow, JD, and Roberts, LJ, II. Mass spectrometric method for quantification of prostanoids (F2-isoprostanes) produced by a non-cyclooxygenase free radical catalyzed mechanism. 1994.

Longmire, AW, Swift, LL, Roberts, LJ, II, Awad, JA, Burk, RF, and Morrow, J.D. Effect of oxygen tension on the generation of F2-isoprostanes and malondialdehyde in peroxidizing rat liver microsomes. 1994.

Stein, DM, Longmire, AW, Minton, TA, Roberts, LJ, II, Pincus, MD, and Morrow, JD. Cyclosporine-induced alterations in renal function are not associated with lipid peroxidation. 1994.

Awad, JA, Morrow, JD, Hill, KE, Roberts, LJ, II, and Burk, RF. Detection and localization of lipid peroxidation in vitamin E and selenium deficient rats using F2-isoprostanes. 1994.

Awad, JA, Burk, RF, and Roberts, LJ, II. Effect of selenium deficiency and glutathione modulating agents on diquat toxicity and lipid peroxidation. 1994.

Longmire, AW, Roberts, LJ, II, and Morrow, J.D. Actions of the E2-isoprostane, 8-iso-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor. 1994.

Roberts, LJ, II, and Morrow, JD. Isoprostanes: Novel markers of endogenous lipid peroxidation and potential mediators of oxidant injury. 1994.

Morrow JD, Roberts LJ. Mass spectrometry of prostanoids: F2-isoprostanes produced by non-cyclooxygenase free radical-catalyzed mechanism. Meth. Enzymol. 1994; 233: 163-74. PMID: 8015454, ISSN: 0076-6879.

Crosland JG, Roberts LJ. Pulsed dye laser therapy for port-wine stains in children [letter]. J. Pediatr. 1994 Jan; 124(1): 161-2. PMID: 8110293, PII: S0022-3476(94)70284-5, ISSN: 0022-3476.

Cox SE, Roberts LJ, Bergstresser PR. Prevention of skin cancer in xeroderma pigmentosum: the physician as advocate. J. Am. Acad. Dermatol. 1993 Dec; 29(6): 1045-6. PMID: 8245244, ISSN: 0190-9622.

Spatz M, Stanimirovic D, Uematsu S, Roberts LJ, Bembry J, McCarron RM. Prostaglandin D2 and endothelin-1 induce the production of prostaglandin F2 alpha, 9 alpha, 11 beta-prostaglandin F2, prostaglandin E2, and thromboxane in capillary endothelium of human brain. Prostaglandins Leukot. Essent. Fatty Acids. 1993 Oct; 49(4): 789-93. PMID: 7505058, ISSN: 0952-3278.

Awad JA, Morrow JD, Roberts LJ. Simplification of the mass spectrometric assay for the major urinary metabolite of prostaglandin D2. J. Chromatogr. 1993 Jul 7/23/1993; 617(1): 124-8. PMID: 8376525.

Roberts LJ. Induction of labour [letter]. BMJ. 1993 Jul 7/3/1993; 307(6895): 66-7. PMID: 8343702, PMCID: PMC1678463, ISSN: 0959-8138.

Kayganich-Harrison KA, Rose DM, Murphy RC, Morrow JD, Roberts LJ. Collision-induced dissociation of F2-isoprostane-containing phospholipids. J. Lipid Res. 1993 Jul; 34(7): 1229-35. PMID: 8371069, ISSN: 0022-2275.

Fukunaga M, Makita N, Roberts LJ, Morrow JD, Takahashi K, Badr KF. Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells. Am. J. Physiol. 1993 Jun; 264(6 Pt 1): C1619-24. PMID: 8333509, ISSN: 0002-9513.

Smith CJ, Morrow JD, Roberts LJ, Marnett LJ. Differentiation of monocytoid THP-1 cells with phorbol ester induces expression of prostaglandin endoperoxide synthase-1 (COX-1). Biochem. Biophys. Res. Commun. 1993 Apr 4/30/1993; 192(2): 787-93. PMID: 8484784, PII: S0006-291X(83)71483-X, DOI: 10.1006/bbrc.1993.1483, ISSN: 0006-291X.

Morrow JD, Moore KP, Awad JA, Ravenscraft MD, Marini G, Badr KF, Williams R, Roberts LJ. Marked overproduction of non-cyclooxygenase derived prostanoids (F2-isoprostanes) in the hepatorenal syndrome. J Lipid Mediat. 1993 Mar; 6(1-3): 417-20. PMID: 8358000, ISSN: 0921-8319.

Awad JA, Morrow JD, Takahashi K, Roberts LJ. Identification of non-cyclooxygenase-derived prostanoid (F2-isoprostane) metabolites in human urine and plasma. J. Biol. Chem. 1993 Feb 2/25/1993; 268(6): 4161-9. PMID: 8440704, ISSN: 0021-9258.

Kang, HK, Morrow, JD, Roberts, LJ, II, Newman, JH, and Banerjee, M. Airway and vascular effects of 8-epi-prostaglandin F2 in isolated perfused rat lung. 1993.

Awad, JA, Morrow, JD, and Roberts, LJ, II. Identification of metabolites of noncyclooxygenase derived prostaglandin F2-like compounds (F2-isoprostanes) in human urine and plasma. 1993.

Kayganich, KA, Rose, DM, Murphy, RC, Morrow, JD, and Roberts, LJ, II. Collision induced dissociation of isoprostane-containing phospholipids. 1993.

Morrow, JD, Moore, KP, Awad, JA, Ravenscraft, MD, Marini, G, Badr, KF, Williams, R, and Roberts, LJ, II. Marked overproduction of non-cycloxygenase derived prostanoids (F2-isoprostanes) in the hepatorenal syndrome. 1993.

Fukunaga, M, Makita, N, Roberts, LJ, II, Morrow, JD, Takahashi, K, and Badr, KF. Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells. 1993.

Kang KH, Morrow JD, Roberts LJ, Newman JH, Banerjee M. Airway and vascular effects of 8-epi-prostaglandin F2 alpha in isolated perfused rat lung. J. Appl. Physiol. 1993 Jan; 74(1): 460-5. PMID: 8444728, ISSN: 8750-7587.

Morrow JD, Awad JA, Kato T, Takahashi K, Badr KF, Roberts LJ, Burk RF. Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation. J. Clin. Invest. 1992 Dec; 90(6): 2502-7. PMID: 1469101, PMCID: PMC443408, DOI: 10.1172/JCI116143, ISSN: 0021-9738.

Fink RL, Roberts LJ, Scott M. The role of manometry, electromyography and radiology in the assessment of intractable constipation. Aust N Z J Surg. 1992 Dec; 62(12): 959-64. PMID: 1456907, ISSN: 0004-8682.

Fink RL, Roberts LJ, Scott M. The role of manometry, electromyography and radiology in the assessment of faecal incontinence. Aust N Z J Surg. 1992 Dec; 62(12): 951-8. PMID: 1456906, ISSN: 0004-8682.

Morrow JD, Awad JA, Boss HJ, Blair IA, Roberts LJ. Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids. Proc. Natl. Acad. Sci. U.S.A. 1992 Nov 11/15/1992; 89(22): 10721-5. PMID: 1438268, PMCID: PMC50413, ISSN: 0027-8424.

Banerjee M, Kang KH, Morrow JD, Roberts LJ, Newman JH. Effects of a novel prostaglandin, 8-epi-PGF2 alpha, in rabbit lung in situ. Am. J. Physiol. 1992 Sep; 263(3 Pt 2): H660-3. PMID: 1415588, ISSN: 0002-9513.

Roberts LJ, Knight VA. A physiologic concept of exercise-induced pulmonary hemorrhage in horses [letter]. J. Am. Vet. Med. Assoc. 1992 Sep 9/1/1992; 201(5): 666-7. PMID: 1399759, ISSN: 0003-1488.

Morrow JD, Minton TA, Roberts LJ. The F2-isoprostane, 8-epi-prostaglandin F2 alpha, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist. Prostaglandins. 1992 Aug; 44(2): 155-63. PMID: 1438879, ISSN: 0090-6980.

Takahashi K, Nammour TM, Fukunaga M, Ebert J, Morrow JD, Roberts LJ, Hoover RL, Badr KF. Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors. J. Clin. Invest. 1992 Jul; 90(1): 136-41. PMID: 1386085, PMCID: PMC443072, DOI: 10.1172/JCI115826, ISSN: 0021-9738.

Morrow JD, Awad JA, Oates JA, Roberts LJ. Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. J. Invest. Dermatol. 1992 May; 98(5): 812-5. PMID: 1373750, ISSN: 0022-202X.

Morrow, JD, Awad, JA, Boss, HJ, Blair, IA, and Roberts, LJ, II. Non- cyclooxygenase derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids. 1992.

Takahashi, K, Nammour, TM, Ebert, J, Morrow, JD, Roberts, LJ, II and Badr, KF. Glomerular actions of a free radical generated novel prostaglandin, 8-epi-prostaglandin F2 in the rat: Evidence for interaction with thromboxane A2 receptors. 1992.

Morrow, JD, Minton, TA, and Roberts, LJ, II. The F2-isoprostane, 8-epi-prostaglandin F2 , a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist. 1992.

Banerjee, M, Kang, KH, Morrow, JD, Roberts, LJ, II, and Newman, JH. Effects of a novel non-cyclooxygenase derived prostaglandin, 8-epi-PGF2 , in rabbit lung in situ. 1992.

Morrow, JD, Awad, JA, Kato, T, Takahashi, K, Badr, KF, Roberts, LJ, II, and Burk, R.F. Formation of novel non-cyclooxygenase derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity, an animal model of lipid peroxidation. 1992.

Roberts LJ, Shaner A, Eckman TA, Tucker DE, Vaccaro JV. Effectively treating stimulant-abusing schizophrenics: mission impossible?. New Dir Ment Health Serv. 1992; (53): 55-65. PMID: 1579119, ISSN: 0193-9416.

Roberts LJ. Elective section after two sections--where's the evidence?. Br J Obstet Gynaecol. 1991 Dec; 98(12): 1199-202. PMID: 1777449, ISSN: 0306-5456.

Roberts LJ, Young KR. The management of prolonged pregnancy--an analysis of women's attitudes before and after term. Br J Obstet Gynaecol. 1991 Nov; 98(11): 1102-6. PMID: 1760421, ISSN: 0306-5456.

Roberts LJ, Luke DA, Rappaport J, Seidman E, Toro PA, Reischl TM. Charting uncharted terrain: a behavioral observation system for mutual help groups. Am J Community Psychol. 1991 Oct; 19(5): 715-37. PMID: 1763786, ISSN: 0091-0562.

Morrow JD, Margolies GR, Rowland J, Roberts LJ. Evidence that histamine is the causative toxin of scombroid-fish poisoning. N. Engl. J. Med. 1991 Mar 3/14/1991; 324(11): 716-20. PMID: 1997836, DOI: 10.1056/NEJM199103143241102, ISSN: 0028-4793.

Roberts LJ, Oates JA. Biochemical diagnosis of systemic mast cell disorders. J. Invest. Dermatol. 1991 Mar; 96(3): 19S-24S; discussion 24S. PMID: 2002247, ISSN: 0022-202X.

Roberts LJ. Idiopathic thrombocytopenic purpura in pregnancy: a randomized trial on the effect of antenatal low dose corticosteroids on neonatal platelet count [letter]. Br J Obstet Gynaecol. 1991 Mar; 98(3): 334-6. PMID: 2021582, ISSN: 0306-5456.

Roberts LJ, Oates JA. Biochemical diagnosis of systemic mast cell disorders. J. Invest. Dermatol. 1991 Mar; 96(3 Suppl): 19S-24S; discussion 24S. PMID: 16799604, PII: 5612609, DOI: 10.1111/1523-1747.ep12468945, ISSN: 1523-1747.

Morrow JD, Prakash C, Awad JA, Duckworth TA, Zackert WE, Blair IA, Oates JA, Roberts LJ. Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assay. Anal. Biochem. 1991 Feb 2/15/1991; 193(1): 142-8. PMID: 2042739, ISSN: 0003-2697.

Guzzo C, Lavker R, Roberts LJ, Fox K, Schechter N, Lazarus G. Urticaria pigmentosa. Systemic evaluation and successful treatment with topical steroids. Arch Dermatol. 1991 Feb; 127(2): 191-6. PMID: 1990983, ISSN: 0003-987X.

Duncan BW, Harrison MR, Zanjani ED, Tarantal AF, Adzick NS, Bradley SM, Longaker MT, Jennings RW, Roberts LJ, Bigler ME. Immunologic evaluation of hematopoietic chimeric rhesus monkeys. Transplant. Proc. 1991 Feb; 23(1 Pt 1): 841-3. PMID: 1671308, ISSN: 0041-1345.

Morrow, JD, and Roberts, LJ, II. . Quantification of non-cyclooxygenase derived prostaglandins as a potential non-invasive marker of oxidative stress. 1991.

Morrow, JD, Rowland, J, Margolies, G, and Roberts, LJ, II. Evidence that histamine is the causative toxin of scombroid fish poisoning. 1991.

Morrow JD, Roberts LJ. Quantification of noncyclooxygenase derived prostanoids as a marker of oxidative stress. Free Radic. Biol. Med. 1991; 10(3-4): 195-200. PMID: 1907587, ISSN: 0891-5849.

Sladek K, Sheller JR, FitzGerald GA, Morrow JD, Roberts LJ. Formation of PGD2 after allergen inhalation in atopic asthmatics. Adv. Prostaglandin Thromboxane Leukot. Res. 1991; 21A: 433-6. PMID: 1847781, ISSN: 0732-8141.

Morrow JD, Hill KE, Burk RF, Nammour TM, Badr KF, Roberts LJ. Formation of unique biologically active prostaglandins in vivo by a non-cyclooxygenase free radical catalyzed mechanism. Adv. Prostaglandin Thromboxane Leukot. Res. 1991; 21A: 125-8. PMID: 1847759, ISSN: 0732-8141.

Morrow JD, Prakash C, Duckworth TA, Zackert WE, Blair IA, Oates JA, Roberts LJ. A stable isotope dilution mass spectrometric assay for the major urinary metabolite of PGD2. Adv. Prostaglandin Thromboxane Leukot. Res. 1991; 21A: 315-8. PMID: 1825560, ISSN: 0732-8141.

Atsmon J, Freeman ML, Meredith MJ, Sweetman BJ, Roberts LJ. Modulation of the antiproliferative activity of 9-deoxy-delta 9,delta 12(E)-PGD2 by conjugation with intracellular glutathione. Adv. Prostaglandin Thromboxane Leukot. Res. 1991; 21B: 887-90. PMID: 1825432, ISSN: 0732-8141.

Arzubiaga C, Morrow J, Roberts LJ, Biaggioni I. Neuropeptide Y, a putative cotransmitter in noradrenergic neurons, induces mast cell degranulation but not prostaglandin D2 release. J. Allergy Clin. Immunol. 1991 Jan; 87(1 Pt 1): 88-93. PMID: 1825102, ISSN: 0091-6749.

Morrow JD, Hill KE, Burk RF, Nammour TM, Badr KF, Roberts LJ. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc. Natl. Acad. Sci. U.S.A. 1990 Dec; 87(23): 9383-7. PMID: 2123555, PMCID: PMC55169, ISSN: 0027-8424.

Roberts LJ. Premature ovarian failure and endometrial ablation [letter]. Br J Hosp Med. 1990 Nov; 44(5): 318. PMID: 2275991, ISSN: 0007-1064.

Sebaldt RJ, Sheller JR, Oates JA, Roberts LJ, FitzGerald GA. Inhibition of eicosanoid biosynthesis by glucocorticoids in humans. Proc. Natl. Acad. Sci. U.S.A. 1990 Sep; 87(18): 6974-8. PMID: 2169616, PMCID: PMC54664, ISSN: 0027-8424.

Atsmon J, Sweetman BJ, Baertschi SW, Harris TM, Roberts LJ. Formation of thiol conjugates of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 and delta 12(E)-prostaglandin D2. Biochemistry. 1990 Apr 4/17/1990; 29(15): 3760-5. PMID: 2340271, ISSN: 0006-2960.

Boh E, Roberts LJ, Lieu TS, Gammon WR, Sontheimer RD. Epidermolysis bullosa acquisita preceding the development of systemic lupus erythematosus. J. Am. Acad. Dermatol. 1990 Apr; 22(4): 587-93. PMID: 2319019, ISSN: 0190-9622.

Atsmon J, Freeman ML, Meredith MJ, Sweetman BJ, Roberts LJ. Conjugation of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 with intracellular glutathione and enhancement of its antiproliferative activity by glutathione depletion. Cancer Res. 1990 Mar 3/15/1990; 50(6): 1879-85. PMID: 2306739, ISSN: 0008-5472.

Morrow, JD, Hill, KE, Burk, RF, Nammour, TM, Badr, KF, and Roberts, LJ, II. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase free radical catalyzed mechanism. 1990.

Morrow JD, Harris TM, Roberts LJ. Noncyclooxygenase oxidative formation of a series of novel prostaglandins: analytical ramifications for measurement of eicosanoids. Anal. Biochem. 1990 Jan; 184(1): 1-10. PMID: 2321745, ISSN: 0003-2697.

Smith S, Anthony L, Roberts LJ, Oates JA, Pincus T. Resolution of musculoskeletal symptoms in the carcinoid syndrome after treatment with the somatostatin analog octreotide. Ann. Intern. Med. 1990 Jan 1/1/1990; 112(1): 66-8. PMID: 2293820, ISSN: 0003-4819.

Smith WL, Borgeat P, Hamberg M, Roberts LJ, Willis Al, Yamamoto S, Ramwell PW, Rokach J, Samuelsson B, Corey EJ. Nomenclature. Meth. Enzymol. 1990; 187: 1-9. PMID: 2233335, ISSN: 0076-6879.

Wendelborn DF, Morrow JD, Roberts LJ. Quantification of 9 alpha, 11 beta-prostaglandin F2 by stable isotope dilution mass spectrometric assay. Meth. Enzymol. 1990; 187: 51-62. PMID: 2122188, ISSN: 0076-6879.

Hendin BN, Longaker MT, Finkbeiner WE, Roberts LJ, Stern R. Hyaluronic acid deposition in cardiac myxomas: localization using a hyaluronate-specific binding protein. Am J Cardiovasc Pathol. 1990; 3(3): 209-15. PMID: 1710472, ISSN: 0887-8005.

Fleck RM, Barnadas M, Schulz WW, Roberts LJ, Freeman RG. Harlequin ichthyosis: an ultrastructural study. J. Am. Acad. Dermatol. 1989 Nov; 21(5 Pt 1): 999-1006. PMID: 2478600, ISSN: 0190-9622.

Morrow JD, Parsons WG, Roberts LJ. Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. Prostaglandins. 1989 Aug; 38(2): 263-74. PMID: 2475889, ISSN: 0090-6980.

Roberts LJ. Long-term survival of a harlequin fetus. J. Am. Acad. Dermatol. 1989 Aug; 21(2 Pt 2): 335-9. PMID: 2754067, ISSN: 0190-9622.

Parsons WG, Roberts LJ. Transformation of prostaglandin D2 to isomeric prostaglandin F2 compounds by human eosinophils: a potential mast cell-eosinophil interaction. Adv. Prostaglandin Thromboxane Leukot. Res. 1989; 19: 499-502. PMID: 2526527, ISSN: 0732-8141.

Dworski R, Sheller JR, Wickersham NE, Oates JA, Brigham KL, Roberts LJ, Fitzgerald GA. Allergen-stimulated release of mediators into sheep bronchoalveolar lavage fluid. Effect of cyclooxygenase inhibition. Am. Rev. Respir. Dis. 1989 Jan; 139(1): 46-51. PMID: 2492175, DOI: 10.1164/ajrccm/139.1.46, ISSN: 0003-0805.

Parsons WG, Roberts LJ. Transformation of prostaglandin D2 to isomeric prostaglandin F2 compounds by human eosinophils. A potential mast cell-eosinophil interaction. J. Immunol. 1988 Oct 10/1/1988; 141(7): 2413-9. PMID: 3139758, ISSN: 0022-1767.

Oates JA, FitzGerald GA, Branch RA, Jackson EK, Knapp HR, Roberts LJ. Clinical implications of prostaglandin and thromboxane A2 formation (2). N. Engl. J. Med. 1988 Sep 9/22/1988; 319(12): 761-7. PMID: 3045551, DOI: 10.1056/NEJM198809223191206, ISSN: 0028-4793.

Oates JA, FitzGerald GA, Branch RA, Jackson EK, Knapp HR, Roberts LJ. Clinical implications of prostaglandin and thromboxane A2 formation (1). N. Engl. J. Med. 1988 Sep 9/15/1988; 319(11): 689-98. PMID: 3045550, DOI: 10.1056/NEJM198809153191106, ISSN: 0028-4793.

Dworski R, Wendelborn DF, Sheller JR, FitzGerald GA, Roberts LJ. Prostaglandins in Ascaris antigen [letter]. J. Allergy Clin. Immunol. 1988 Sep; 82(3 Pt 1): 484. PMID: 3170997, ISSN: 0091-6749.

Toro PA, Reischl TM, Zimmerman MA, Rappaport J, Seidman E, Luke DA, Roberts LJ. Professionals in mutual help groups: impact on social climate and members' behavior. J Consult Clin Psychol. 1988 Aug; 56(4): 631-2. PMID: 3198826, ISSN: 0022-006X.

Soberman RJ, Sutyak JP, Okita RT, Wendelborn DF, Roberts LJ, Austen KF. The identification and formation of 20-aldehyde leukotriene B4. J. Biol. Chem. 1988 Jun 6/15/1988; 263(17): 7996-8002. PMID: 2836406, ISSN: 0021-9258.

Roberts LJ. Carcinoid syndrome and disorders of systemic mast-cell activation including systemic mastocytosis. Endocrinol. Metab. Clin. North Am. 1988 Jun; 17(2): 415-36. PMID: 3042393, ISSN: 0889-8529.

Roberts LJ, Fink CW. Childhood polymyositis/dermatomyositis. Clin. Dermatol. 1988 Apr; 6(2): 36-46, 49. PMID: 3293743, ISSN: 0738-081X.

Rendon MI, Roberts LJ, Tharp MD. Linear cutaneous lesions of Kaposi's sarcoma: a clinical clue to the diagnosis of acquired immunodeficiency syndrome. Arch Dermatol. 1988 Mar; 124(3): 327-9. PMID: 3345084, ISSN: 0003-987X.

Wendelborn DF, Seibert K, Roberts LJ. Isomeric prostaglandin F2 compounds arising from prostaglandin D2: a family of icosanoids produced in vivo in humans. Proc. Natl. Acad. Sci. U.S.A. 1988 Jan; 85(2): 304-8. PMID: 3422430, PMCID: PMC279536, ISSN: 0027-8424.

Arthur H, Austin L, Roberts LJ. A pilot trial of plasma infusions in Duchenne muscular dystrophy. Aust Paediatr J. 1988; 24 Suppl 1: 24-30. PMID: 3202736, ISSN: 0004-993X.

Stier CT, Roberts LJ, Wong PY. Renal response to 9 alpha, 11 beta-prostaglandin F2 in the rat. J. Pharmacol. Exp. Ther. 1987 Nov; 243(2): 487-91. PMID: 3479549, ISSN: 0022-3565.

Lynes WL, Flynn SD, Shortliffe LD, Lemmers M, Zipser R, Roberts LJ, Stamey TA. Mast cell involvement in interstitial cystitis. J. Urol. 1987 Oct; 138(4): 746-52. PMID: 3477649, ISSN: 0022-5347.

Roberts LJ, Sontheimer RD. Chronic bullous dermatosis of childhood: immunopathologic studies. Pediatr Dermatol. 1987 May; 4(1): 6-10. PMID: 3295827, ISSN: 0736-8046.

Roberts LJ, Shadwick CF, Bergstresser PR. Zinc deficiency in two full-term breast-fed infants. J. Am. Acad. Dermatol. 1987 Feb; 16(2 Pt 1): 301-4. PMID: 3819064, ISSN: 0190-9622.

Prakash C, Roberts LJ, Saleh S, Taber DF, Blair IA. Synthesis of putative prostaglandin D2 metabolites. Adv. Prostaglandin Thromboxane Leukot. Res. 1987; 17B: 781-7. PMID: 2960191, ISSN: 0732-8141.

Roberts LJ. Recent metabolic findings bring into question the reliability of existing methods for quantification of PGF2 alpha and its metabolites in human biological fluids. Adv. Prostaglandin Thromboxane Leukot. Res. 1987; 17B: 608-10. PMID: 2960165, ISSN: 0732-8141.

Wendelborn DF, Seibert K, Roberts LJ. Isomeric prostaglandin F2 compounds: a new family of eicosanoids produced in vivo in humans. Adv. Prostaglandin Thromboxane Leukot. Res. 1987; 17A: 47-9. PMID: 2959099, ISSN: 0732-8141.

Roberts LJ, Seibert K, Liston TE, Tantengco MV, Robertson RM. PGD2 is transformed by human coronary arteries to 9 alpha, 11 beta-PGF2, which contracts human coronary artery rings. Adv. Prostaglandin Thromboxane Leukot. Res. 1987; 17A: 427-9. PMID: 2959090, ISSN: 0732-8141.

Seibert K, Sheller JR, Roberts LJ. 9 alpha, 11 beta-prostaglandin F2: formation and metabolism by human lung and contractile effects on human bronchial smooth muscle. Adv. Prostaglandin Thromboxane Leukot. Res. 1987; 17A: 189-91. PMID: 2959045, ISSN: 0732-8141.

Seibert K, Sheller JR, Roberts LJ. (5Z,13E)-(15S)-9 alpha,11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2): formation and metabolism by human lung and contractile effects on human bronchial smooth muscle. Proc. Natl. Acad. Sci. U.S.A. 1987 Jan; 84(1): 256-60. PMID: 3467352, PMCID: PMC304182, ISSN: 0027-8424.

Watanabe K, Iguchi Y, Iguchi S, Arai Y, Hayaishi O, Roberts LJ. Stereospecific conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and prostaglandin H2 to prostaglandin F2 alpha by PGF synthetase. Adv. Prostaglandin Thromboxane Leukot. Res. 1987; 17A: 44-6. PMID: 2959094, ISSN: 0732-8141.

Massicot JG, Soberman RJ, Ackerman NR, Heavey D, Roberts LJ, Austen KF. Workshop: Potential therapeutic uses of inhibitors of leukotriene generation and function. June 23, 1986, Bethesda, Maryland. Sponsored by the National Institute of Allergy and Infectious Diseases and the World Health Organization Collaborating Center for Allergic Diseases. Prostaglandins. 1986 Oct; 32(4): 481-94. PMID: 3025934, ISSN: 0090-6980.

Murray JJ, Tonnel AB, Brash AR, Roberts LJ, Gosset P, Workman R, Capron A, Oates JA. Release of prostaglandin D2 into human airways during acute antigen challenge. N. Engl. J. Med. 1986 Sep 9/25/1986; 315(13): 800-4. PMID: 3462506, DOI: 10.1056/NEJM198609253151304, ISSN: 0028-4793.

Vire G, Roberts LJ, King LE. Urticaria pigmentosa and natural sunlight. J. Am. Acad. Dermatol. 1986 Apr; 14(4): 687-8. PMID: 3958284, ISSN: 0190-9622.

Watanabe K, Iguchi Y, Iguchi S, Arai Y, Hayaishi O, Roberts LJ. Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. Proc. Natl. Acad. Sci. U.S.A. 1986 Mar; 83(6): 1583-7. PMID: 3456602, PMCID: PMC323127, ISSN: 0027-8424.

Forman MB, Oates JA, Robertson D, Robertson RM, Roberts LJ, Virmani R. Increased adventitial mast cells in a patient with coronary spasm. N. Engl. J. Med. 1985 Oct 10/31/1985; 313(18): 1138-41. PMID: 2413358, DOI: 10.1056/NEJM198510313131807, ISSN: 0028-4793.

Liston TE, Roberts LJ. Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. J. Biol. Chem. 1985 Oct 10/25/1985; 260(24): 13172-80. PMID: 3863815, ISSN: 0021-9258.

Roberts LJ, Sweetman BJ. Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. Prostaglandins. 1985 Sep; 30(3): 383-400. PMID: 3864190, ISSN: 0090-6980.

Liston TE, Roberts LJ. Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans. Proc. Natl. Acad. Sci. U.S.A. 1985 Sep; 82(18): 6030-4. PMID: 3862115, PMCID: PMC390693, ISSN: 0027-8424.

Roberts LJ, Aulsebrook KA, Oates JA. Comparative evaluation of the radioenzymatic method for the determination of urinary histamine with a mass spectrometric assay. J. Chromatogr. 1985 Feb 2/27/1985; 338(1): 41-9. PMID: 4019656.

Rappaport J, Seidman E, Toro PA, McFadden LS, Reischl TM, Roberts LJ, Salem DA, Stein CH, Zimmerman MA. Collaborative research with a mutual help organization. Soc Policy. 1985; 15(3): 12-24. PMID: 10270879, ISSN: 0037-7783.

Murray JJ, Tonnel AB, Brash AR, Roberts LJ, Gosset P, Workman R, Capron A, Oates JA. Prostaglandin D2 is released during acute allergic bronchospasm in man. Trans. Assoc. Am. Physicians. 1985; 98: 275-80. PMID: 3870298, ISSN: 0066-9458.

Liston TE, Oates JA, Roberts LJ. Prostaglandin D2 is metabolized in humans to 9 alpha,11 beta-prostaglandin F2, a novel biologically active prostaglandin. Adv. Prostaglandin Thromboxane Leukot. Res. 1985; 15: 365-7. PMID: 2936123, ISSN: 0732-8141.

Roberts LJ. Pentafluorobenzyl derivative of histamine for determination by gas chromatography-negative ion chemical ionization mass spectrometry. J. Chromatogr. 1984 Mar 3/30/1984; 287(1): 155-60. PMID: 6725454.

Roberts LJ. Recurrent syncope due to systemic mastocytosis. Hypertension. 1984 Mar; 6(2 Pt 1): 285-94. PMID: 6202635, ISSN: 0194-911X.

Roberts LJ, Oates JA. Accurate and efficient method for quantification of urinary histamine by gas chromatography negative ion chemical ionization mass spectrometry. Anal. Biochem. 1984 Jan; 136(1): 258-63. PMID: 6711813, PII: 0003-2697(84)90333-6, ISSN: 0003-2697.

Roberts LJ, Ross E. Chronic airflow limitation. Nurse Pract. 1983 Nov; 8(10): 21, 24-5. PMID: 6646535, ISSN: 0361-1817.

Scott HW, Parris WC, Sandidge PC, Oates JA, Roberts LJ. Hazards in operative management of patients with systemic mastocytosis. Ann. Surg. 1983 May; 197(5): 507-14. PMID: 6189461, PMCID: PMC1353019, ISSN: 0003-4932.

FitzGerald GA, Oates JA, Hawiger J, Maas RL, Roberts LJ, Lawson JA, Brash AR. Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. J. Clin. Invest. 1983 Mar; 71(3): 676-88. PMID: 6338043, PMCID: PMC436917, ISSN: 0021-9738.

Turk J, Oates JA, Roberts LJ. Intervention with epinephrine in hypotension associated with mastocytosis. J. Allergy Clin. Immunol. 1983 Feb; 71(2): 189-92. PMID: 6296213, PII: 0091-6749(83)90098-2, ISSN: 0091-6749.

Roberts LJ, Bloomgarden ZT, Marney SR, Rabin D, Oates JA. Histamine release from a gastric carcinoid: provocation by pentagastrin and inhibition by somatostatin. Gastroenterology. 1983 Feb; 84(2): 272-5. PMID: 6184258, PII: S0016508583000177, ISSN: 0016-5085.

Turk J, Rand TH, Maas RL, Lawson JA, Brash AR, Roberts LJ, Colley DG, Oates JA. Identification of lipoxygenase products from arachidonic acid metabolism in stimulated murine eosinophils. Biochim. Biophys. Acta. 1983 Jan 1/7/1983; 750(1): 78-90. PMID: 6402030, PII: 0005-2760(83)90206-0, ISSN: 0006-3002.

Kootte AM, Haak A, Roberts LJ. The flush syndrome: an expression of systemic mastocytosis with increased prostaglandin D2 production. Neth J Med. 1983; 26(1): 18-20. PMID: 6572798, ISSN: 0300-2977.

FitzGerald GA, Maas RL, Lawson JA, Oates JA, Roberts LJ, Brash AR. Aspirin inhibits endogenous prostacyclin and thromboxane biosynthesis in man. Adv. Prostaglandin Thromboxane Leukot. Res. 1983; 11: 265-6. PMID: 6221534, ISSN: 0732-8141.

Turk J, Maas RL, Roberts LJ, Brash AR, Oates JA. Conjugated triene metabolites of arachidonic acid derived from dioxygenation at carbon-15: origin from eosinophil and mechanisms of biosynthesis. Adv. Prostaglandin Thromboxane Leukot. Res. 1983; 11: 123-32. PMID: 6221514, ISSN: 0732-8141.

Lewis RA, Soter NA, Diamond PT, Austen KF, Oates JA, Roberts LJ. Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE. J. Immunol. 1982 Oct; 129(4): 1627-31. PMID: 6809826, ISSN: 0022-1767.

Turk J, Maas RL, Brash AR, Roberts LJ, Oates JA. Arachidonic acid 15-lipoxygenase products from human eosinophils. J. Biol. Chem. 1982 Jun 6/25/1982; 257(12): 7068-76. PMID: 6806264, ISSN: 0021-9258.

Roberts LJ, Fields JP, Oates JA. Mastocytosis without urticaria pigmentosa: a frequently unrecognized cause of recurrent syncope. Trans. Assoc. Am. Physicians. 1982; 95: 36-41. PMID: 7182985, ISSN: 0066-9458.

Roberts LJ, Turk JW, Oates JA. Shock syndrome associated with mastocytosis: pharmacologic reversal of the acute episode and therapeutic prevention of recurrent attacks. Adv Shock Res. 1982; 8: 145-52. PMID: 7136941, ISSN: 0195-878X.

Maas RL, Taber DF, Roberts LJ. Quantitative assay of urinary 2,3-dinor thromboxane B2 by GC-MS. Meth. Enzymol. 1982; 86: 592-603. PMID: 7132771, ISSN: 0076-6879.

Roberts LJ. Quantification of the PGD2 urinary metabolite 9 alpha-hydroxy-11, 15-dioxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid by stable isotope dilution mass spectrometric assay. Meth. Enzymol. 1982; 86: 559-70. PMID: 6752644, ISSN: 0076-6879.

Roberts LJ, Brash AR, Oates JA. Metabolic fate of thromboxane A2 and prostacyclin. Adv. Prostaglandin Thromboxane Leukot. Res. 1982; 10: 211-25. PMID: 6216783, ISSN: 0732-8141.

Fitzgerald GA, Maas RL, Stein R, Oates JA, Roberts LJ. Intravenous prostacyclin in thrombotic thrombocytopenic purpura. Ann. Intern. Med. 1981 Sep; 95(3): 319-22. PMID: 7023309, ISSN: 0003-4819.

Roberts LJ, Sweetman BJ, Oates JA. Metabolism of thromboxane B2 in man. Identification of twenty urinary metabolites. J. Biol. Chem. 1981 Aug 8/25/1981; 256(16): 8384-93. PMID: 7263660, ISSN: 0021-9258.

Feely J, Heidemann H, Gerkens J, Roberts LJ, Branch RA. Sodium depletion enhances nephrotoxicity of amphotericin B. Lancet. 1981 Jun 6/27/1981; 1(8235): 1422-3. PMID: 6113376, ISSN: 0140-6736.

Robertson RM, Robertson D, Roberts LJ, Maas RL, FitzGerald GA, Friesinger GC, Oates JA. Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials. N. Engl. J. Med. 1981 Apr 4/23/1981; 304(17): 998-1003. PMID: 7010173, DOI: 10.1056/NEJM198104233041703, ISSN: 0028-4793.

Roberts LJ, Sweetman BJ, Maas RL, Hubbard WC, Oates JA. Clinical application of PG and TX metabolite quantification. Prog. Lipid Res. 1981; 20: 117-21. PMID: 6804954, ISSN: 0163-7827.

Lewis RA, Holgate ST, Roberts LJ, Oates JA, Austen KF. Preferential generation of prostaglandin D2 by rat and human mast cells. Kroc Found Ser. 1981; 14: 239-54. PMID: 6796654, ISSN: 0361-0489.

Roberts LJ, Sweetman BJ, Lewis RA, Austen KF, Oates JA. Increased production of prostaglandin D2 in patients with systemic mastocytosis. N. Engl. J. Med. 1980 Dec 12/11/1980; 303(24): 1400-4. PMID: 6107852, DOI: 10.1056/NEJM198012113032405, ISSN: 0028-4793.

Holgate ST, Lewis RA, Maguire JF, Roberts LJ, Oates JA, Austen KF. Effects of prostaglandin D2 on rat serosal mast cells: discordance between immunologic mediator release and cyclic AMP levels. J. Immunol. 1980 Sep; 125(3): 1367-73. PMID: 6251134, ISSN: 0022-1767.

Bertagna XY, Bloomgarden ZT, Rabin D, Roberts LJ, Orth DN. Molecular weight forms of immunoreactive calcitonin in a patient with medullary carcinoma of the thyroid: dynamic studies with calcium, pentagastrin and somatostatin. Clin. Endocrinol. (Oxf). 1980 Aug; 13(2): 115-23. PMID: 6108170, ISSN: 0300-0664.

Roberts LJ, Sweetman BJ, Lewis RA, Folarin VF, Austen KF, Oates JA. Markedly increased synthesis of prostaglandin D2 in systemic mastocytosis. Trans. Assoc. Am. Physicians. 1980; 93: 141-7. PMID: 7245571, ISSN: 0066-9458.

Oates JA, Roberts LJ, Sweetman BJ, Maas RL, Gerkens JF, Taber DF. Metabolism of the prostaglandins and thromboxanes. Adv Prostaglandin Thromboxane Res. 1980; 6: 35-41. PMID: 6992534, ISSN: 0361-5952.

Roberts LJ, Lewis RA, Oates JA, Austen KF. Prostaglandin thromboxane, and 12-hydroxy-5,8,10,14-eicosatetraenoic acid production by ionophore-stimulated rat serosal mast cells. Biochim. Biophys. Acta. 1979 Nov 11/21/1979; 575(2): 185-92. PMID: 389290, PII: 0005-2760(79)90020-1, ISSN: 0006-3002.

Lewis RA, Holgate ST, Roberts LJ, Maguire JF, Oates JA, Austen KF. Effects of indomethacin on cyclic nucleotide levels and histamine release from rat serosal mast cells. J. Immunol. 1979 Oct; 123(4): 1663-8. PMID: 90096, ISSN: 0022-1767.

Roberts LJ, Marney SR, Oates JA. Blockade of the flush associated with metastatic gastric carcinoid by combined histamine H1 and H2 receptor antagonists. Evidence for an important role of H2 receptors in human vasculature. N. Engl. J. Med. 1979 Feb 2/1/1979; 300(5): 236-8. PMID: 32486, DOI: 10.1056/NEJM197902013000506, ISSN: 0028-4793.

Roberts LJ, Hubbard WC, Bloomgarden ZT, Bertagna XY, McKenna TJ, Rabinowitz D, Oates JA. Prostaglandins: role in the humoral manifestations of medullary carcinoma of the thyroid and inhibition by somatostatin. Trans. Assoc. Am. Physicians. 1979; 92: 286-91. PMID: 44926, ISSN: 0066-9458.

Samuelsson B, Hamberg M, Roberts LJ, Oates JA, Nelson NA. Nomenclature for thromboxanes. Prostaglandins. 1978 Dec; 16(6): 857-60. PMID: 748979, ISSN: 0090-6980.

Roberts LJ, Sweetman BJ, Oates JA. Metabolism of thromboxane B2 in the monkey. J. Biol. Chem. 1978 Aug 8/10/1978; 253(15): 5305-18. PMID: 97291, ISSN: 0021-9258.

Oelz O, Knapp HR, Roberts LJ, Oelz R, Sweetman BJ, Oates JA, Reed PW. Calcium-dependent stimulation of thromboxane and prostaglandin biosynthesis by ionophores. Adv Prostaglandin Thromboxane Res. 1978; 3: 147-58. PMID: 350020, ISSN: 0361-5952.

Roberts LJ, Sweetman BJ, Payne NA, Oates JA. Metabolism of thromboxane B2 in man. Identification of the major urinary metabolite. J. Biol. Chem. 1977 Nov 11/10/1977; 252(21): 7415-7. PMID: 914816, ISSN: 0021-9258.

Knapp HR, Oelz O, Roberts LJ, Sweetman BJ, Oates JA, Reed PW. Ionophores stimulate prostaglandin and thromboxane biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 1977 Oct; 74(10): 4251-5. PMID: 270668, PMCID: PMC431917, ISSN: 0027-8424.

Roberts LJ, Sweetman BJ, Morgan JL, Payne NA, Oates JA. Identification of the major urinary metabolite of thromboxane B2 in the monkey. Prostaglandins. 1977 Apr; 13(4): 631-47. PMID: 404671, ISSN: 0090-6980.

Duncan GW, Roberts LJ, Wison JP. Paroxysmal hypertensive hemicrania. Headache. 1977 Mar; 17(1): 5-6. PMID: 845027, ISSN: 0017-8748.

Ellis EF, Oelz O, Roberts LJ, Payne NA, Sweetman BJ, Nies AS, Oates JA. Coronary arterial smooth muscle contraction by a substance released from platelets: evidence that it is thromboxane A2. Science. 1976 Sep 9/17/1976; 193(4258): 1135-7. PMID: 959827, ISSN: 0036-8075.

Wait B, Blair R, Roberts LJ. Energy intake of well-nourished children and adolescents. Am. J. Clin. Nutr. 1969 Oct; 22(10): 1383-96. PMID: 5344924, ISSN: 0002-9165.

Fernández NA, Burgos JC, Roberts LJ, Asenjo CF. Nutritional status of people in isolated areas of Puerto Rico. Survey of Barrio Montones 4, Las Piedras. J Am Diet Assoc. 1968 Aug; 53(2): 119-26. PMID: 5667626, ISSN: 0002-8223.

Fernández NA, Burgos JC, Roberts LJ, Asenjo CF. Nutritional status in Puerto Rican slum area. Am. J. Clin. Nutr. 1968 Jun; 21(6): 646-56. PMID: 4233187, ISSN: 0002-9165.

Fernández NA, Burgos JC, Roberts LJ, Asenjo CF. Nutritional status of people in isolated areas of Puerto Rico. Survey of Barrio Masas 2, Gurabo, Puerto Rico. Bol Asoc Med P R. 1967 Dec; 59(12): 503-14. PMID: 5257811, ISSN: 0004-4849.

Fernández NA, Burgos JC, Plough IC, Roberts LJ, Asenjo CF. Nutritional status of people in isolated areas of Puerto Rico. Survey of Barrio Naranjo, Moca, Puerto Rico. Am. J. Clin. Nutr. 1966 Oct; 19(4): 269-84. PMID: 5920498, ISSN: 0002-9165.

Fernández NA, Burgos JC, Plough IC, Roberts LJ, Asenjo CF. Nutritional status of people in isolated areas of Puerto Rico. Survey of Barrio Mavilla, Vega Alta, Puerto Rico. Am. J. Clin. Nutr. 1965 Nov; 17(5): 305-16. PMID: 4221246, ISSN: 0002-9165.

ROBERTS LJ. A COOPERATIVE NUTRITION RESEARCH PROGRAM FOR PUERTO RICO. I. BACKGROUND AND GENERAL PLAN. J Am Diet Assoc. 1964 Jan; 44: 18-21. PMID: 14075403, ISSN: 0002-8223.

PLOUGH IC, FERNANDEZLOPEZ NA, ANGEL CR, ROBERTS LJ. A NUTRITION SURVEY OF THREE RURAL PUERTO RICAN COMMUNITIES. Bol Asoc Med P R. 1963 Dec; 55: SUPPL:1-51. PMID: 14191873, ISSN: 0004-4849.

ROBERTS LJ. Beginnings of the recommended dietary allowances. J Am Diet Assoc. 1958 Sep; 34(9): 903-8. PMID: 13575091, ISSN: 0002-8223.

ROBERTS LJ. A basic food pattern for Puerto Rico. J Am Diet Assoc. 1954 Nov; 30(11): 1097-100. PMID: 13211172, ISSN: 0002-8223.

ROBERTS LJ. A practical nutrition program for Puerto Rico. Nutr. Rev. 1950 Nov; 8(11): 321-4. PMID: 14780581, ISSN: 0029-6643.

King CG, Eddy WH, Heseltine MM, Hunscher HA, Mitchell HS, Remington RE, Roberts LJ, Sebrell WH, Sedgwick J. Report of the Committee on Nutritional Problems (Nutrition as a Science in Wartime) : Food and Nutrition Section. Am J Public Health Nations Health. 1944 Jul; 34(7): 774-9. PMID: 18016026, PMCID: PMC1625091, ISSN: 0002-9572.

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