Kelli Lynn Boyd, D.V.M., Ph.D.

Associate Professor

kelli.l.boyd@vanderbilt.edu
Faculty Appointments
Associate Professor of Pathology, Microbiology and Immunology
Education
Ph.D., VETERINARY PATHOLOGY, University of Georgia, Athens, GeorgiaD.V.M., Mississippi State University, Mississippi State, MississippiB.S., Mississippi State University, Mississippi State, Mississippi
Office Address
AA 6206 MCN
TN 2130
Research Keywords
Comparative Pathology, Mouse Pathology
Publications
Watanabe M, Mishin VP, Brown SA, Russell CJ, Boyd K, Babu YS, Taylor G, Xiong X, Yan X, Portner A, Alymova IV. Effect of hemagglutinin-neuraminidase inhibitors BCX 2798 and BCX 2855 on growth and pathogenicity of Sendai/human parainfluenza type 3 chimera virus in mice. Antimicrob. Agents Chemother [print-electronic]. 2009 Sep; 53(9): 3942-51. PMID: 19564364, PMCID: PMC2737897, PII: AAC.00220-09, DOI: 10.1128/AAC.00220-09, ISSN: 1098-6596.

Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H. The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat. Immunol [print-electronic]. 2009 Jul; 10(7): 769-77. PMID: 19483717, PMCID: PMC2732340, PII: ni.1743, DOI: 10.1038/ni.1743, ISSN: 1529-2916.

Thomas PG, Dash P, Aldridge JR, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, Doherty PC, Kanneganti TD. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity [print-electronic]. 2009 Apr 4/17/2009; 30(4): 566-75. PMID: 19362023, PMCID: PMC2765464, PII: S1074-7613(09)00140-X, DOI: 10.1016/j.immuni.2009.02.006, ISSN: 1097-4180.

Lamkanfi M, Moreira LO, Makena P, Spierings DC, Boyd K, Murray PJ, Green DR, Kanneganti TD. Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. Blood [print-electronic]. 2009 Mar 3/19/2009; 113(12): 2742-5. PMID: 19168786, PMCID: PMC2661861, PII: blood-2008-09-178038, DOI: 10.1182/blood-2008-09-178038, ISSN: 1528-0020.

Steimer DA, Boyd K, Takeuchi O, Fisher JK, Zambetti GP, Opferman JT. Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function. Blood [print-electronic]. 2009 Mar 3/19/2009; 113(12): 2805-15. PMID: 19064728, PMCID: PMC2661864, PII: blood-2008-05-159145, DOI: 10.1182/blood-2008-05-159145, ISSN: 1528-0020.

Karlström A, Boyd KL, English BK, McCullers JA. Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenza. J. Infect. Dis. 2009 Feb 2/1/2009; 199(3): 311-9. PMID: 19113989, PMCID: PMC2687083, DOI: 10.1086/596051, ISSN: 0022-1899.

Pestina TI, Hargrove PW, Jay D, Gray JT, Boyd KM, Persons DA. Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin. Mol. Ther [print-electronic]. 2009 Feb; 17(2): 245-52. PMID: 19050697, PMCID: PMC2670570, PII: mt2008259, DOI: 10.1038/mt.2008.259, ISSN: 1525-0024.

Yang L, Boyd K, Kaste SC, Kamdem Kamdem L, Rahija RJ, Relling MV. A mouse model for glucocorticoid-induced osteonecrosis: effect of a steroid holiday. J. Orthop. Res. 2009 Feb; 27(2): 169-75. PMID: 18683891, PMCID: PMC2718787, DOI: 10.1002/jor.20733, ISSN: 1554-527X.

Alymova IV, Taylor G, Mishin VP, Watanabe M, Murti KG, Boyd K, Chand P, Babu YS, Portner A. Loss of the N-linked glycan at residue 173 of human parainfluenza virus type 1 hemagglutinin-neuraminidase exposes a second receptor-binding site. J. Virol [print-electronic]. 2008 Sep; 82(17): 8400-10. PMID: 18579600, PMCID: PMC2519627, PII: JVI.00474-08, DOI: 10.1128/JVI.00474-08, ISSN: 1098-5514.

Krishnamurthy P, Schwab M, Takenaka K, Nachagari D, Morgan J, Leslie M, Du W, Boyd K, Cheok M, Nakauchi H, Marzolini C, Kim RB, Poonkuzhali B, Schuetz E, Evans W, Relling M, Schuetz JD. Transporter-mediated protection against thiopurine-induced hematopoietic toxicity. Cancer Res. 2008 Jul 7/1/2008; 68(13): 4983-9. PMID: 18593894, PMCID: PMC3323115, PII: 68/13/4983, DOI: 10.1158/0008-5472.CAN-07-6790, ISSN: 1538-7445.

Tian Y, Pate C, Andreolotti A, Wang L, Tuomanen E, Boyd K, Claro E, Jackowski S. Cytokine secretion requires phosphatidylcholine synthesis. J. Cell Biol. 2008 Jun 6/16/2008; 181(6): 945-57. PMID: 18559668, PMCID: PMC2426940, PII: jcb.200706152, DOI: 10.1083/jcb.200706152, ISSN: 1540-8140.

Holst J, Wang H, Eder KD, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K, Chruscinski A, Smeyne R, van Oers NS, Utz PJ, Vignali DA. Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nat. Immunol [print-electronic]. 2008 Jun; 9(6): 658-66. PMID: 18469818, PII: ni.1611, DOI: 10.1038/ni.1611, ISSN: 1529-2916.

Chao JR, Parganas E, Boyd K, Hong CY, Opferman JT, Ihle JN. Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature [print-electronic]. 2008 Mar 3/6/2008; 452(7183): 98-102. PMID: 18288109, PII: nature06604, DOI: 10.1038/nature06604, ISSN: 1476-4687.

Marino R, Martinez C, Boyd K, Dominici M, Hofmann TJ, Horwitz EM. Transplantable marrow osteoprogenitors engraft in discrete saturable sites in the marrow microenvironment. Exp. Hematol [print-electronic]. 2008 Mar; 36(3): 360-8. PMID: 18179857, PMCID: PMC3391997, PII: S0301-472X(07)00658-3, DOI: 10.1016/j.exphem.2007.11.002, ISSN: 0301-472X.

Zhan X, Hurwitz JL, Krishnamurthy S, Takimoto T, Boyd K, Scroggs RA, Surman S, Portner A, Slobod KS. Respiratory syncytial virus (RSV) fusion protein expressed by recombinant Sendai virus elicits B-cell and T-cell responses in cotton rats and confers protection against RSV subtypes A and B. Vaccine [print-electronic]. 2007 Dec 12/17/2007; 25(52): 8782-93. PMID: 18037543, PMCID: PMC2238687, PII: S0264-410X(07)01191-7, DOI: 10.1016/j.vaccine.2007.10.038, ISSN: 0264-410X.

Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 2007 Nov 11/22/2007; 450(7169): 566-9. PMID: 18033300, PII: nature06306, DOI: 10.1038/nature06306, ISSN: 1476-4687.

Torchia EC, Boyd K, Rehg JE, Qu C, Baker SJ. EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol. Cell. Biol [print-electronic]. 2007 Nov; 27(22): 7918-34. PMID: 17875932, PMCID: PMC2169157, PII: MCB.00099-07, DOI: 10.1128/MCB.00099-07, ISSN: 1098-5549.

Ajioka I, Martins RA, Bayazitov IT, Donovan S, Johnson DA, Frase S, Cicero SA, Boyd K, Zakharenko SS, Dyer MA. Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell. 2007 Oct 10/19/2007; 131(2): 378-90. PMID: 17956737, PMCID: PMC2203617, PII: S0092-8674(07)01224-X, DOI: 10.1016/j.cell.2007.09.036, ISSN: 0092-8674.

McAuley JL, Hornung F, Boyd KL, Smith AM, McKeon R, Bennink J, Yewdell JW, McCullers JA. Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe. 2007 Oct 10/11/2007; 2(4): 240-9. PMID: 18005742, PMCID: PMC2083255, PII: S1931-3128(07)00216-8, DOI: 10.1016/j.chom.2007.09.001, ISSN: 1934-6069.

Vigerust DJ, Ulett KB, Boyd KL, Madsen J, Hawgood S, McCullers JA. N-linked glycosylation attenuates H3N2 influenza viruses. J. Virol [print-electronic]. 2007 Aug; 81(16): 8593-600. PMID: 17553891, PMCID: PMC1951338, PII: JVI.00769-07, DOI: 10.1128/JVI.00769-07, ISSN: 0022-538X.

Ozbek U, Kandilci A, van Baal S, Bonten J, Boyd K, Franken P, Fodde R, Grosveld GC. SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice. Am. J. Pathol [print-electronic]. 2007 Aug; 171(2): 654-66. PMID: 17569777, PMCID: PMC1934515, PII: S0002-9440(10)61998-0, DOI: 10.2353/ajpath.2007.060934, ISSN: 0002-9440.

Hulse-Post DJ, Franks J, Boyd K, Salomon R, Hoffmann E, Yen HL, Webby RJ, Walker D, Nguyen TD, Webster RG. Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks. J. Virol [print-electronic]. 2007 Aug; 81(16): 8515-24. PMID: 17553873, PMCID: PMC1951362, PII: JVI.00435-07, DOI: 10.1128/JVI.00435-07, ISSN: 0022-538X.

Inoue A, Li T, Roby SK, Valentine MB, Inoue M, Boyd K, Kidd VJ, Lahti JM. Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. Cell Cycle [print-electronic]. 2007 Jul 7/1/2007; 6(13): 1646-54. PMID: 17611414, PII: 4411, ISSN: 1551-4005.

Keller UB, Old JB, Dorsey FC, Nilsson JA, Nilsson L, MacLean KH, Chung L, Yang C, Spruck C, Boyd K, Reed SI, Cleveland JL. Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. EMBO J [print-electronic]. 2007 May 5/16/2007; 26(10): 2562-74. PMID: 17464290, PMCID: PMC1868903, PII: 7601691, DOI: 10.1038/sj.emboj.7601691, ISSN: 0261-4189.

Li N, Boyd K, Dempsey PJ, Vignali DA. Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development. J. Immunol. 2007 Apr 4/1/2007; 178(7): 4214-21. PMID: 17371977, PII: 178/7/4214, ISSN: 0022-1767.

Humberd J, Boyd K, Webster RG. Emergence of influenza A virus variants after prolonged shedding from pheasants. J. Virol [print-electronic]. 2007 Apr; 81(8): 4044-51. PMID: 17267493, PMCID: PMC1866108, PII: JVI.02346-06, DOI: 10.1128/JVI.02346-06, ISSN: 0022-538X.

Gingras S, Pelletier S, Boyd K, Ihle JN. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). PLoS ONE. 2007; 2(8): e808. PMID: 17726538, PMCID: PMC1950078, DOI: 10.1371/journal.pone.0000808, ISSN: 1932-6203.

Funk AJ, Rogers TD, Dobbins RM, Boyd K. Exophthalmos and corneal edema in a young ferret. Diagnosis: glaucoma. Lab Anim (NY). 2006 Oct; 35(9): 19, 20-1. PMID: 17008903, PII: laban1006-19, DOI: 10.1038/laban1006-19, ISSN: 0093-7355.

Park TJ, Boyd K, Curran T. Cardiovascular and craniofacial defects in Crk-null mice. Mol. Cell. Biol. 2006 Aug; 26(16): 6272-82. PMID: 16880535, PMCID: PMC1592792, PII: 26/16/6272, DOI: 10.1128/MCB.00472-06, ISSN: 0270-7306.

Sun Y, Boyd K, Xu W, Ma J, Jackson CW, Fu A, Shillingford JM, Robinson GW, Hennighausen L, Hitzler JK, Ma Z, Morris SW. Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function. Mol. Cell. Biol. 2006 Aug; 26(15): 5809-26. PMID: 16847333, PMCID: PMC1592762, PII: 26/15/5809, DOI: 10.1128/MCB.00024-06, ISSN: 0270-7306.

Lee Y, Miller HL, Russell HR, Boyd K, Curran T, McKinnon PJ. Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res. 2006 Jul 7/15/2006; 66(14): 6964-71. PMID: 16849540, PII: 66/14/6964, DOI: 10.1158/0008-5472.CAN-06-0505, ISSN: 0008-5472.

Xu W, Fukuyama T, Ney PA, Wang D, Rehg J, Boyd K, van Deursen JM, Brindle PK. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood [print-electronic]. 2006 Jun 6/1/2006; 107(11): 4407-16. PMID: 16424387, PMCID: PMC1895794, PII: 2005-08-3263, DOI: 10.1182/blood-2005-08-3263, ISSN: 0006-4971.

Hill WA, Randolph MM, Lokey SJ, Hayes E, Boyd KL, Mandrell TD. Efficacy and safety of topical selamectin to eradicate pinworm (Syphacia spp.) infections in rats (Rattus norvegicus) and mice (Mus musculus). J. Am. Assoc. Lab. Anim. Sci. 2006 May; 45(3): 23-6. PMID: 16642966, ISSN: 1559-6109.

Peltola VT, Boyd KL, McAuley JL, Rehg JE, McCullers JA. Bacterial sinusitis and otitis media following influenza virus infection in ferrets. Infect. Immun. 2006 May; 74(5): 2562-7. PMID: 16622191, PMCID: PMC1459735, PII: 74/5/2562, DOI: 10.1128/IAI.74.5.2562-2567.2006, ISSN: 0019-9567.

Desmots F, Russell HR, Lee Y, Boyd K, McKinnon PJ. The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development. Mol. Cell. Biol. 2005 Dec; 25(23): 10329-37. PMID: 16287848, PMCID: PMC1291232, PII: 25/23/10329, DOI: 10.1128/MCB.25.23.10329-10337.2005, ISSN: 0270-7306.

Kasper LH, Boussouar F, Boyd K, Xu W, Biesen M, Rehg J, Baudino TA, Cleveland JL, Brindle PK. Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J [print-electronic]. 2005 Nov 11/16/2005; 24(22): 3846-58. PMID: 16237459, PMCID: PMC1283945, PII: 7600846, DOI: 10.1038/sj.emboj.7600846, ISSN: 0261-4189.

Harvey NL, Srinivasan RS, Dillard ME, Johnson NC, Witte MH, Boyd K, Sleeman MW, Oliver G. Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat. Genet [print-electronic]. 2005 Oct; 37(10): 1072-81. PMID: 16170315, PII: ng1642, DOI: 10.1038/ng1642, ISSN: 1061-4036.

Dominici M, Tadjali M, Kepes S, Allay ER, Boyd K, Ney PA, Horwitz E, Persons DA. Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny. Genesis. 2005 May; 42(1): 17-22. PMID: 15828004, DOI: 10.1002/gene.20121, ISSN: 1526-954X.

Cardone M, Kandilci A, Carella C, Nilsson JA, Brennan JA, Sirma S, Ozbek U, Boyd K, Cleveland JL, Grosveld GC. The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis. Mol. Cell. Biol. 2005 Mar; 25(6): 2395-405. PMID: 15743832, PMCID: PMC1061619, PII: 25/6/2395, DOI: 10.1128/MCB.25.6.2395-2405.2005, ISSN: 0270-7306.

Alymova IV, Portner A, Takimoto T, Boyd KL, Babu YS, McCullers JA. The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae. Antimicrob. Agents Chemother. 2005 Jan; 49(1): 398-405. PMID: 15616320, PMCID: PMC538863, PII: 49/1/398, DOI: 10.1128/AAC.49.1.398-405.2005, ISSN: 0066-4804.

Nilsson JA, Nilsson LM, Keller U, Yokota Y, Boyd K, Cleveland JL. Id2 is dispensable for myc-induced lymphomagenesis. Cancer Res. 2004 Oct 10/15/2004; 64(20): 7296-301. PMID: 15492249, PII: 64/20/7296, DOI: 10.1158/0008-5472.CAN-04-2133, ISSN: 0008-5472.