Dale Scott Edgerton, Ph.D.

Research Associate Professor

dale.edgerton@vanderbilt.edu

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Faculty Appointments
Research Associate Professor of Molecular Physiology and Biophysics
Education
Ph.D., Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TennesseeB.Sc., Biology, Boise State University , Boise, Idaho
Office Address
710 RRB
TN 0615
Publications
Corbett BA, Swain DM, Newsom C, Wang L, Song Y, Edgerton D. Biobehavioral profiles of arousal and social motivation in autism spectrum disorders. J Child Psychol Psychiatry [print-electronic]. 2014 Aug; 55(8): 924-34. PMID: 24329926, PMCID: PMC4055549, DOI: 10.1111/jcpp.12184, ISSN: 1469-7610.

Saraswathi V, Ramnanan CJ, Wilks AW, Desouza CV, Eller AA, Murali G, Ramalingam R, Milne GL, Coate KC, Edgerton DS. Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice. Metab. Clin. Exp [print-electronic]. 2013 Nov; 62(11): 1673-85. PMID: 23987235, PII: S0026-0495(13)00224-2, DOI: 10.1016/j.metabol.2013.07.007, ISSN: 1532-8600.

Edgerton DS, An Z, Johnson KM, Farmer T, Farmer B, Neal D, Cherrington AD. Effects of intraportal exenatide on hepatic glucose metabolism in the conscious dog. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2013 Jul 7/1/2013; 305(1): E132-9. PMID: 23673158, PMCID: PMC3725568, PII: ajpendo.00160.2013, DOI: 10.1152/ajpendo.00160.2013, ISSN: 1522-1555.

Edgerton DS, Cherrington AD. Glucagon's yin and yang effects on hepatic glucose production. Nat. Med. 2013 Jun; 19(6): 674-5. PMID: 23744146, PII: nm.3202, DOI: 10.1038/nm.3202, ISSN: 1546-170X.

Winnick JJ, Ramnanan CJ, Saraswathi V, Roop J, Scott M, Jacobson P, Jung P, Basu R, Cherrington AD, Edgerton DS. Effects of 11ß-hydroxysteroid dehydrogenase-1 inhibition on hepatic glycogenolysis and gluconeogenesis. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2013 Apr 4/1/2013; 304(7): E747-56. PMID: 23403942, PMCID: PMC3625750, PII: ajpendo.00639.2012, DOI: 10.1152/ajpendo.00639.2012, ISSN: 1522-1555.

Ramnanan CJ, Kraft G, Smith MS, Farmer B, Neal D, Williams PE, Lautz M, Farmer T, Donahue EP, Cherrington AD, Edgerton DS. Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog. Diabetes [print-electronic]. 2013 Jan; 62(1): 74-84. PMID: 23011594, PMCID: PMC3526039, PII: db12-0148, DOI: 10.2337/db12-0148, ISSN: 1939-327X.

Ramnanan CJ, Edgerton DS, Cherrington AD. Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production. Cell Metab. 2012 May 5/2/2012; 15(5): 656-64. PMID: 22560218, PMCID: PMC3348512, PII: S1550-4131(12)00101-5, DOI: 10.1016/j.cmet.2012.03.006, ISSN: 1932-7420.

Ramnanan CJ, Edgerton DS, Kraft G, Cherrington AD. Physiologic action of glucagon on liver glucose metabolism. Diabetes Obes Metab. 2011 Oct; 13 Suppl 1: 118-25. PMID: 21824265, DOI: 10.1111/j.1463-1326.2011.01454.x, ISSN: 1463-1326.

Ramnanan CJ, Saraswathi V, Smith MS, Donahue EP, Farmer B, Farmer TD, Neal D, Williams PE, Lautz M, Mari A, Cherrington AD, Edgerton DS. Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs. J. Clin. Invest [print-electronic]. 2011 Sep; 121(9): 3713-23. PMID: 21865644, PMCID: PMC3163950, PII: 45472, DOI: 10.1172/JCI45472, ISSN: 1558-8238.

Edgerton DS, Cherrington AD. Glucagon as a critical factor in the pathology of diabetes. Diabetes. 2011 Feb; 60(2): 377-80. PMID: 21270249, PMCID: PMC3028334, PII: 60/2/377, DOI: 10.2337/db10-1594, ISSN: 1939-327X.

Ramnanan CJ, Edgerton DS, Rivera N, Irimia-Dominguez J, Farmer B, Neal DW, Lautz M, Donahue EP, Meyer CM, Roach PJ, Cherrington AD. Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo. Diabetes [print-electronic]. 2010 Jun; 59(6): 1302-11. PMID: 20185816, PMCID: PMC2874690, PII: db09-1625, DOI: 10.2337/db09-1625, ISSN: 1939-327X.

Edgerton DS, Basu R, Ramnanan CJ, Farmer TD, Neal D, Scott M, Jacobson P, Rizza RA, Cherrington AD. Effect of 11 beta-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2010 May; 298(5): E1019-26. PMID: 20159854, PMCID: PMC2867371, PII: ajpendo.00740.2009, DOI: 10.1152/ajpendo.00740.2009, ISSN: 1522-1555.

Edgerton DS, Ramnanan CJ, Grueter CA, Johnson KM, Lautz M, Neal DW, Williams PE, Cherrington AD. Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo. Diabetes [print-electronic]. 2009 Dec; 58(12): 2766-75. PMID: 19755527, PMCID: PMC2780867, PII: db09-0328, DOI: 10.2337/db09-0328, ISSN: 1939-327X.

Edgerton DS, Cherrington AD, Neal DW, Scott M, Lautz M, Brown N, Petro J, Hobbs CH, Leach C, Del Parigi A, Strack TR. Inhaled insulin is associated with prolonged enhancement of glucose disposal in muscle and liver in the canine. J. Pharmacol. Exp. Ther [print-electronic]. 2009 Mar; 328(3): 970-5. PMID: 19098161, PMCID: PMC3202424, PII: jpet.108.146985, DOI: 10.1124/jpet.108.146985, ISSN: 1521-0103.

Edgerton DS, Johnson KM, Cherrington AD. Current strategies for the inhibition of hepatic glucose production in type 2 diabetes. Front Biosci (Landmark Ed). 2009; 14: 1169-81. PMID: 19273123, PII: 3301, ISSN: 1093-4715.

Edgerton DS, Johnson KM, Neal DW, Scott M, Hobbs CH, Zhang X, Duttaroy A, Cherrington AD. Inhibition of dipeptidyl peptidase-4 by vildagliptin during glucagon-like Peptide 1 infusion increases liver glucose uptake in the conscious dog. Diabetes [print-electronic]. 2009 Jan; 58(1): 243-9. PMID: 18840785, PMCID: PMC2606880, PII: db08-0515, DOI: 10.2337/db08-0515, ISSN: 1939-327X.

Johnson KM, Edgerton DS, Rodewald T, Scott M, Farmer B, Neal D, Cherrington AD. Intraportally delivered GLP-1, in the presence of hyperglycemia induced via peripheral glucose infusion, does not change whole body glucose utilization. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2008 Feb; 294(2): E380-4. PMID: 18056788, PII: 00642.2007, DOI: 10.1152/ajpendo.00642.2007, ISSN: 0193-1849.

An Z, DiCostanzo CA, Moore MC, Edgerton DS, Dardevet DP, Neal DW, Cherrington AD. Effects of the nitric oxide donor SIN-1 on net hepatic glucose uptake in the conscious dog. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2008 Feb; 294(2): E300-6. PMID: 18029444, PII: 00380.2007, DOI: 10.1152/ajpendo.00380.2007, ISSN: 0193-1849.

Cherrington AD, Moore MC, Sindelar DK, Edgerton DS. Insulin action on the liver in vivo. Biochem. Soc. Trans. 2007 Nov; 35(Pt 5): 1171-4. PMID: 17956305, PII: BST0351171, DOI: 10.1042/BST0351171, ISSN: 0300-5127.

Johnson KM, Edgerton DS, Rodewald T, Scott M, Farmer B, Neal D, Cherrington AD. Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing pancreatic hormone levels. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2007 Oct; 293(4): E1085-91. PMID: 17684104, PII: 00275.2007, DOI: 10.1152/ajpendo.00275.2007, ISSN: 0193-1849.

Nelson RH, Edgerton DS, Basu R, Roesner JC, Cherrington AD, Miles JM. Triglyceride uptake and lipoprotein lipase-generated fatty acid spillover in the splanchnic bed of dogs. Diabetes [print-electronic]. 2007 Jul; 56(7): 1850-5. PMID: 17416801, PII: db06-1657, DOI: 10.2337/db06-1657, ISSN: 1939-327X.

Rivera N, Everett-Grueter CA, Edgerton DS, Rodewald T, Neal DW, Nishimura E, Larsen MO, Jacobsen LO, Kristensen K, Brand CL, Cherrington AD. A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog. J. Pharmacol. Exp. Ther [print-electronic]. 2007 May; 321(2): 743-52. PMID: 17308040, PII: jpet.106.115717, DOI: 10.1124/jpet.106.115717, ISSN: 0022-3565.

Edgerton DS, Cherrington AD, Williams P, Neal DW, Scott M, Bowen L, Wilson W, Hobbs CH, Leach C, Kuo MC, Strack TR. Inhalation of human insulin (exubera) augments the efficiency of muscle glucose uptake in vivo. Diabetes. 2006 Dec; 55(12): 3604-10. PMID: 17130510, PII: 55/12/3604, DOI: 10.2337/db06-0718, ISSN: 0012-1797.

Edgerton DS, Stettler KM, Neal DW, Scott M, Bowen L, Wilson W, Hobbs CH, Leach C, Strack TR, Cherrington AD. Inhalation of human insulin is associated with improved insulin action compared with subcutaneous injection and endogenous secretion in dogs. J. Pharmacol. Exp. Ther [print-electronic]. 2006 Dec; 319(3): 1258-64. PMID: 16963622, PII: jpet.106.108373, DOI: 10.1124/jpet.106.108373, ISSN: 0022-3565.

Basu R, Edgerton DS, Singh RJ, Cherrington A, Rizza RA. Splanchnic cortisol production in dogs occurs primarily in the liver: evidence for substantial hepatic specific 11beta hydroxysteroid dehydrogenase type 1 activity. Diabetes. 2006 Nov; 55(11): 3013-9. PMID: 17065337, PII: 55/11/3013, DOI: 10.2337/db06-0601, ISSN: 0012-1797.

Edgerton DS, Jacobson PB, Opgenorth TJ, Zinker B, Beno D, von Geldern T, Ohman L, Scott M, Neal D, Cherrington AD. Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production. Metab. Clin. Exp. 2006 Sep; 55(9): 1255-62. PMID: 16919547, PII: S0026-0495(06)00178-8, DOI: 10.1016/j.metabol.2006.05.011, ISSN: 0026-0495.

Everett-Grueter C, Edgerton DS, Donahue EP, Vaughan S, Chu CA, Sindelar DK, Cherrington AD. The effect of an acute elevation of NEFA concentrations on glucagon-stimulated hepatic glucose output. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2006 Sep; 291(3): E449-59. PMID: 16608886, PII: 00043.2006, DOI: 10.1152/ajpendo.00043.2006, ISSN: 0193-1849.

Edgerton DS, Lautz M, Scott M, Everett CA, Stettler KM, Neal DW, Chu CA, Cherrington AD. Insulin's direct effects on the liver dominate the control of hepatic glucose production. J. Clin. Invest. 2006 Feb; 116(2): 521-7. PMID: 16453026, PMCID: PMC1359060, DOI: 10.1172/JCI27073, ISSN: 0021-9738.

Gustavson SM, Rajotte RV, Hunkeler D, Lakey JR, Edgerton DS, Neal DW, Snead WL, Penaloza AR, Cherrington AD. Islet auto-transplantation into an omental or splenic site results in a normal beta cell but abnormal alpha cell response to mild non-insulin-induced hypoglycemia. Am. J. Transplant. 2005 Oct; 5(10): 2368-77. PMID: 16162184, PII: AJT1041, DOI: 10.1111/j.1600-6143.2005.01041.x, ISSN: 1600-6135.

Jacobson PB, von Geldern TW, Ohman L, Osterland M, Wang J, Zinker B, Wilcox D, Nguyen PT, Mika A, Fung S, Fey T, Goos-Nilsson A, Grynfarb M, Barkhem T, Marsh K, Beno DW, Nga-Nguyen B, Kym PR, Link JT, Tu N, Edgerton DS, Cherrington A, Efendic S, Lane BC, Opgenorth TJ. Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes. J. Pharmacol. Exp. Ther [print-electronic]. 2005 Jul; 314(1): 191-200. PMID: 15784656, PII: jpet.104.081257, DOI: 10.1124/jpet.104.081257, ISSN: 0022-3565.

Edgerton DS, Neal DW, Scott M, Bowen L, Wilson W, Hobbs CH, Leach C, Sivakumaran S, Strack TR, Cherrington AD. Inhalation of insulin (Exubera) is associated with augmented disposal of portally infused glucose in dogs. Diabetes. 2005 Apr; 54(4): 1164-70. PMID: 15793257, PII: 54/4/1164, ISSN: 0012-1797.

Cardin S, Pagliassotti MJ, Moore MC, Edgerton DS, Lautz M, Farmer B, Neal DW, Cherrington AD. Vagal cooling and concomitant portal norepinephrine infusion do not reduce net hepatic glucose uptake in conscious dogs. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2004 Oct; 287(4): R742-8. PMID: 15166005, PII: 00041.2004, DOI: 10.1152/ajpregu.00041.2004, ISSN: 0363-6119.

Cherrington AD, Neal DW, Edgerton DS, Glass D, Bowen L, Hobbs CH, Leach C, Rosskamp R, Strack TR. Inhalation of insulin in dogs: assessment of insulin levels and comparison to subcutaneous injection. Diabetes. 2004 Apr; 53(4): 877-81. PMID: 15047601, ISSN: 0012-1797.

Edgerton DS, Cardin S, Neal D, Farmer B, Lautz M, Pan C, Cherrington AD. Effects of hyperglycemia on hepatic gluconeogenic flux during glycogen phosphorylase inhibition in the conscious dog. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Apr; 286(4): E510-22. PMID: 14644767, PII: 00211.2003, DOI: 10.1152/ajpendo.00211.2003, ISSN: 0193-1849.

Moore MC, Cardin S, Edgerton DS, Farmer B, Neal DW, Lautz M, Cherrington AD. Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Feb; 286(2): E226-33. PMID: 14519598, PII: 00343.2003, DOI: 10.1152/ajpendo.00343.2003, ISSN: 0193-1849.

Edgerton DS, Cardin S, Pan C, Neal D, Farmer B, Converse M, Cherrington AD. Effects of insulin deficiency or excess on hepatic gluconeogenic flux during glycogenolytic inhibition in the conscious dog. Diabetes. 2002 Nov; 51(11): 3151-62. PMID: 12401705, ISSN: 0012-1797.

Hornbuckle LA, Edgerton DS, Ayala JE, Svitek CA, Oeser JK, Neal DW, Cardin S, Cherrington AD, O'Brien RM. Selective tonic inhibition of G-6-Pase catalytic subunit, but not G-6-P transporter, gene expression by insulin in vivo. Am. J. Physiol. Endocrinol. Metab. 2001 Oct; 281(4): E713-25. PMID: 11551847, ISSN: 0193-1849.

Edgerton DS, Cardin S, Emshwiller M, Neal D, Chandramouli V, Schumann WC, Landau BR, Rossetti L, Cherrington AD. Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism. Diabetes. 2001 Aug; 50(8): 1872-82. PMID: 11473051, ISSN: 0012-1797.

Cardin S, Jackson PA, Edgerton DS, Neal DW, Coffey CS, Cherrington AD. Effect of vagal cooling on the counterregulatory response to hypoglycemia induced by a low dose of insulin in the conscious dog. Diabetes. 2001 Mar; 50(3): 558-64. PMID: 11246875, ISSN: 0012-1797.

Cardin S, Emshwiller M, Jackson PA, Snead WL, Hastings J, Edgerton DS, Cherrington AD. Portal glucose infusion increases hepatic glycogen deposition in conscious unrestrained rats. J. Appl. Physiol. 1999 Oct; 87(4): 1470-5. PMID: 10517780, ISSN: 8750-7587.