Lourdes Estrada, Ph.D.

Assistant Professor

lourdes.estrada@vanderbilt.edu
Faculty Appointments
Assistant Professor of Cancer Biology
Education
Ph.D., Pharmacology, University of Michigan, Ann Arbor, MichiganM.S., Pharmacology, University of Michigan, Ann Arbor, MichiganB.S., Biology, University of Puerto Rico, Rio Piedras, Puerto Rico
Office Address
446 PRB
2220 Pierce Avenue
Nashville, TN 6840
Research Keywords
Mathematical modeling of cancer progression
Publications
Anderson AR, Hassanein M, Branch KM, Lu J, Lobdell NA, Maier J, Basanta D, Weidow B, Narasanna A, Arteaga CL, Reynolds AB, Quaranta V, Estrada L, Weaver AM. Microenvironmental independence associated with tumor progression. Cancer Res [print-electronic]. 2009 Nov 11/15/2009; 69(22): 8797-806. PMID: 19887618, PMCID: PMC2783510, PII: 0008-5472.CAN-09-0437, DOI: 10.1158/0008-5472.CAN-09-0437, ISSN: 1538-7445.

Kam Y, Karperien A, Weidow B, Estrada L, Anderson AR, Quaranta V. Nest expansion assay: a cancer systems biology approach to in vitro invasion measurements. BMC Res Notes. 2009; 2: 130. PMID: 19594934, PMCID: PMC2716356, PII: 1756-0500-2-130, DOI: 10.1186/1756-0500-2-130, ISSN: 1756-0500.

Enderling H, Alexander NR, Clark ES, Branch KM, Estrada L, Crooke C, Jourquin J, Lobdell N, Zaman MH, Guelcher SA, Anderson AR, Weaver AM. Dependence of invadopodia function on collagen fiber spacing and cross-linking: computational modeling and experimental evidence. Biophys. J [print-electronic]. 2008 Sep; 95(5): 2203-18. PMID: 18515372, PMCID: PMC2517013, PII: S0006-3495(08)78369-3, DOI: 10.1529/biophysj.108.133199, ISSN: 1542-0086.

Georgescu W, Jourquin J, Estrada L, Anderson AR, Quaranta V, Wikswo JP. Model-controlled hydrodynamic focusing to generate multiple overlapping gradients of surface-immobilized proteins in microfluidic devices. Lab Chip [print-electronic]. 2008 Feb; 8(2): 238-44. PMID: 18231661, PMCID: PMC4357342, DOI: 10.1039/b716203k, ISSN: 1473-0197.

Kam Y, Guess C, Estrada L, Weidow B, Quaranta V. A novel circular invasion assay mimics in vivo invasive behavior of cancer cell lines and distinguishes single-cell motility in vitro. BMC Cancer. 2008; 8: 198. PMID: 18625060, PMCID: PMC2491634, PII: 1471-2407-8-198, DOI: 10.1186/1471-2407-8-198, ISSN: 1471-2407.

Hou P, Estrada L, Kinley AW, Parsons JT, Vojtek AB, Gorski JL. Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape. Hum. Mol. Genet. 2003 Aug 8/15/2003; 12(16): 1981-93. PMID: 12913069, ISSN: 0964-6906.

Gao J, Estrada L, Cho S, Ellis RE, Gorski JL. The Caenorhabditis elegans homolog of FGD1, the human Cdc42 GEF gene responsible for faciogenital dysplasia, is critical for excretory cell morphogenesis. Hum. Mol. Genet. 2001 Dec 12/15/2001; 10(26): 3049-62. PMID: 11751687, ISSN: 0964-6906.

Estrada L, Caron E, Gorski JL. Fgd1, the Cdc42 guanine nucleotide exchange factor responsible for faciogenital dysplasia, is localized to the subcortical actin cytoskeleton and Golgi membrane. Hum. Mol. Genet. 2001 Mar 3/1/2001; 10(5): 485-95. PMID: 11181572, ISSN: 0964-6906.

Gorski JL, Estrada L, Hu C, Liu Z. Skeletal-specific expression of Fgd1 during bone formation and skeletal defects in faciogenital dysplasia (FGDY; Aarskog syndrome). Dev. Dyn. 2000 Aug; 218(4): 573-86. PMID: 10906777, PII: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1015>3.0.CO;2-F, DOI: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1015>3.0.CO;2-F, ISSN: 1058-8388.

Morishima Y, Kanelakis KC, Silverstein AM, Dittmar KD, Estrada L, Pratt WB. The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system. J. Biol. Chem. 2000 Mar 3/10/2000; 275(10): 6894-900. PMID: 10702249, ISSN: 0021-9258.

Estrada L, Kanelakis KC, Levy GN, Weber WW. Tissue- and gender-specific expression of N-acetyltransferase 2 (Nat2*) during development of the outbred mouse strain CD-1. Drug Metab. Dispos. 2000 Feb; 28(2): 139-46. PMID: 10640510, ISSN: 0090-9556.

García-Arrarás JE, Estrada-Rodgers L, Santiago R, Torres II, Díaz-Miranda L, Torres-Avillán I. Cellular mechanisms of intestine regeneration in the sea cucumber, Holothuria glaberrima Selenka (Holothuroidea:Echinodermata). J. Exp. Zool. 1998 Jul 7/1/1998; 281(4): 288-304. PMID: 9658592, PII: 10.1002/(SICI)1097-010X(19980701)281:4<288::AID-JEZ5>3.0.CO;2-K, ISSN: 0022-104X.

Estrada-Rodgers L, Levy GN, Weber WW. Substrate selectivity of mouse N-acetyltransferases 1, 2, and 3 expressed in COS-1 cells. Drug Metab. Dispos. 1998 May; 26(5): 502-5. PMID: 9571233, ISSN: 0090-9556.

Estrada-Rodgers L, Levy GN, Weber WW. Characterization of a hormone response element in the mouse N-acetyltransferase 2 (Nat2*) promoter. Gene Expr. 1998; 7(1): 13-24. PMID: 9572394, ISSN: 1052-2166.

Levy GN, Rodgers L, Weber WW. Effects of heredity on response to drugs and environmental chemicals: construction of rodent models. Chem. Res. Toxicol. 1996 Dec; 9(8): 1215-24. PMID: 8951222, PII: tx960082y, DOI: 10.1021/tx960082y, ISSN: 0893-228X.