Maria del Pilar Aguinaga, Ph.D.

Professor

maria.del.pilar.aguinaga@vanderbilt.edu
Faculty Appointments
Professor of Obstetrics and Gynecology at Meharry Medical College Adjunct Associate Professor of Medicine at Vanderbilt University School of MedicineAdjunct Professor of Medicine
Education
Ph.D., Biophysics-Molecular Biology, Kanazawa University Medical School, Kanazawa, JapanM.S., Biochemistry, Universidad Peruana Cayetano Heredia, Lima, PeruB.S., Biology, Universidad Peruana Cayetano Heredia, Lima, Peru
Office Address
Meharry Sickle Cell Center
5th Floor Old Hospital
1005 Dr. D.B. Todd Jr. Blvd.
Nashville, TN 37208
Research Keywords
Newborn Screening for Hemoglobinopathies
Clinical Research Keywords
Diagnosis of hemoglobinopathies
Publications
Iyamu E.W., Fasold H., Roa D., Aguinaga M.d.P., Asakura T., Turner E.A. Hdroxyurea-induced oxidative damage of normal and sickle cell hemoglobins in vitro: Amelioration by radical scavengers. J Clin Lab Anal. 2001; 15((1)): 1-7.

Aguinaga MD, Kutlar F, Turner EA, Park D. Hb Inkster [alpha85(F6)Asp-->Val] found in a caucasian male with polycythemia. Hemoglobin. 2000 Nov; 24(4): 333-9. PMID: 11186265, ISSN: 0363-0269.

Shokrani M, Terrell F, Turner EA, Aguinaga MD. Chromatographic measurements of hemoglobin A2 in blood samples that contain sickle hemoglobin. Ann. Clin. Lab. Sci. 2000 Apr; 30(2): 191-4. PMID: 10807164, ISSN: 0091-7370.

Shokrani, M., Terrell, F., Turner, E.A., and Aguinaga, M.d.P. Chromatographic measurements of Hemoglobin A2. Annals of Clinical Laboratory Science. 2000; 30(4): 191-4.

Young, R.C., Nelson, B.L., Aguinaga, M.d.P., Rachal, R.E., Haliburton, W., Castro, O. Affinity of hemoglobin variants for oxygen; its implications as a measure of therapeutic outcome in sickle cell disease. J. Nat Med Assoc. 2000; 92: 430-5.

Aguinaga MD, Kutlar F, Turner EA, Park D. Hb Inkster [alpha85(F6)Asp-->Val] found in a caucasian male with polycythemia. Hemoglobin. 2000; 24(4): 333-9.

Aguinaga, M.d.P., and Turner, E.A. Letters to the Editor: Hb A2 Chromatographic measurements. Annals of Clinical Laboratory Science. 2000; 30((4)): 431.

Aguinaga MP, Wright CJ, Roa PD, Terrell F, Turner EA, Houston M. Molecular diagnosis and characterization of Hb Z├╝rich [beta63(E7)His-->Arg]] carriers in a Kentucky family. Hemoglobin. 1998 Sep; 22(5-6): 509-15. PMID: 9859934, ISSN: 0363-0269.

Aguinaga, M.d.P., Wright, C.J., Roa, P.D., Terell F., Turner, E.A., and Houston, M. Molecular diagnosis and characterization of hemoglobin β Zurich 63(E7)his arg carriers in a Kentucky family. Hemoglobin 22. 1998; 5 and 6: 509-15.

Iyamu, W.E., Roa, P.D., Kopsombut, P., Aguinaga, M.d.P., and Turner, E.A. New isocratic high performance liquid chromatographic procedure to assay the anti-sickling compound hydroxyurea in plasma with ultraviolet detection system. Jour. Of Chromatography. 1998; 709: 119-26.

Roa D, Kopsombut P, Aguinaga MP, Turner EA. Hydroxyurea-induced denaturation of normal and sickle cell hemoglobins in vitro. J. Clin. Lab. Anal. 1997; 11(4): 208-13. PMID: 9219062, PII: 10.1002/(SICI)1098-2825(1997)11:4<208::AID-JCLA6>3.0.CO;2-4, ISSN: 0887-8013.

Popp, R.A., Popp, D.M., Shinpock, S.G., Yang, N.Y., Mural, J.G., Aguinaga, M.d.P., Kopsombut, P., Roa, P.D., Turner, E.A., and Rubin, E.M. A Transgenic Mouse Model for HbS Antilles. Blood. 1997; 89((11)): 4204-12.

Roa, P.D., Kopsombut, P., Aguinaga, M.d.P. and Turner, E.A. Hydroxyurea induced denaturation of normal and sickle cell hemoglobins in vitro. Journal of Clinical Laboratory Analysis. 1997; 11: 208-13.

Talley, C.J., Turner, E.A., Hatcher, F.M., Aguinaga, M.d.P. and Chakrabarti, P. Tiazofurin-induced autosecretion of IL-6 and hemoglobin production in K562 human leukemia cells. American Journal of Hematology. 1997; 54: 301-5.

Roa, P.D., Aguinaga, M.d.P., Ulloa, V.R., Ruiz, W., and Turner, E.A. Hemoglobinopathy screening of newborns born at 10,000 to 14,000 feet above sea level. Revista Medica Herediana. 1997; 8((3)): 87-91.

Koury, M.J., Park, D.J., Martincic, D., Horne, D.W., Kravstov, V., Whitlock, C., Aguinaga, M.d.P., and Kopsombut, P. Folate Deficiency increases leukemic transformation in Friend-Virus disease. Blood. 1997; 90((10)): 4054-61.

Roa D, Turner EA, Aguinaga MD. Reference ranges for hemoglobin variants by HPLC in African Americans. Ann. Clin. Lab. Sci. 1995 May; 25(3): 228-35. PMID: 7605104, ISSN: 0091-7370.

Robbins V, Aguinaga MP, Valenzuela MS. Efficient isolation of whole genomic DNA from cell cultures and blood samples. BioTechniques. 1995 Mar; 18(3): 414-6, 418. PMID: 7779389, ISSN: 0736-6205.

Roa, P.D., Turner, E.A., and Aguinaga, M.d.P. Reference Ranges for Hemoglobin Variants by HPLC in African Americans. Annals of Clinical Laboratory Sciences. 1995; 25((2)): 179-86.

Robbins, V., Aguinaga, M.d.P., and Valenzuela, M.S. Rapid and efficient isolation of whole DNA from cell cultures and blood samples. Biotechniques. 1995; 18((3)): 415-7.

Aguinaga, M.d.P. Of Mice and Men: Transgenic Models for Sickle Cell Disease. Genome Report. 1994; 3((1)).

Aguinaga, M.d.P., and Turner, E.A. New advances for the treatment of sickle cell disease. Revista Medica Herediana. 1994; 5((4)): 209-11.

Roa, D., Turner, E.A., and Aguinaga, M.d.P. Hemoglobin variant detection from dried blood specimens by HPLC. Annals of Clinical and Laboratory Science. 1993; 23((6)): 433-8.

Aguinaga, M.d.P. What's Wrong With Zurich? Not the City, Hemoglobin. Genome Report. 1993; 1((3)).

Bardhan, S., Sharan, C., Singh, D.N., Turner, E.A., and Aguinaga, M.d.P. A simplified procedure for isolation of highly purified genomic DNA. Bionature. 1992; 1263: 89-94.

Aguinaga M, Sharan C, Singh DN, Kegler D, Siddiqui KA, Valenzuela MS. Chromosomal mapping and nucleotide sequence of a human DNA autonomously replicating sequence. Genomics. 1989 Oct; 5(3): 605-11. PMID: 2613242, ISSN: 0888-7543.

Aguinaga, M.d.P., Sharan, C., Singh, D.N., Kegoer, D., Siddiqui, K.A,I. And Valenzuela, M.S. Chromosomal mapping and nucleotide sequence of a human DNA autonomously replicating sequence. Genomics. 1989; 5: 605-11.

Aguinaga, M.d.P., Sharan, C., Singh, D.N., and Valenzuela, M.S. Efficient transfer of DNA to nylon membranes using vacuum blotting in presence of alkali. Biotechniques. 1989; 7((10)): 1077-9.

Aguinaga, M.d.P., Kiper, C.E., and Valenzuela, M.S. Enriched autonomously replicating sequences in a nuclear-matrix DNA complex isolated from synchronized HeLa cells. Biochemical and Biophysical Research Communication. 1987; 144: 1018-24.

Valenzuela, M.S., and Aguinaga, M.d.P. Rapid isolation of recombinant plasmids containing inserts of known sizes. Biotechniques. 1986; 4((2)): 204-7.

Aguinaga, M.d.P. Effects of ribosomal RNA promoters on plasmid replication. Journal of the Juzen Medical Society. 1983; 92: 851-61.

Valenzuela, M.S., Aguinaga, M.d.P., and Inman, R.B. Isolation of DNA fragments containing replication growing forks from both E. coli and B. subtilis. Molecular General Genetics. 1981; 181: 241-7.