Pampee Paul Young, Ph.D., M.D.

Associate Professor

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Faculty Appointments
Associate Professor of Pathology, Microbiology and Immunology Associate Professor of Medicine
M.D., Medicine, University of Texas Southwestern Medical School, Dallas, TexasPh.D., Cell Regulation, University of Texas Southwestern Medical School, Dallas, TexasB.A., Biochemistry, Rice University, Houston, Texas
Office Address
C3321A MCN
1161 21st Ave South
Nashville, TN 37232
Research Description

My laboratory studies the cellular drivers and signaling mechanisms that regulate tissue repair and regeneration. We use mouse models of myocardial and complex cutaneous tissue injuries to study endogenous regulators of repair as well as exogenous factors, including the role of stem cell-mediated cellular therapies, that regulate repair. My research interests dovetails well with my clinical role as Medical Director of Transfusion Medicine and of the Stem Cell Laboratory. In addition, I am dedicated to training future biomedical scientists and medical residents. Our long term goal is to identify signaling pathways which can be targeted to improve tissue repair.

Project 1

Role of Wnt signaling in repair vs. regeneration. Using both genetic models and novel small molecule Wnt pathway modulators, we have identified a pro-regenerative role in both cardiac and complex cutaneous wounds for the canonical Wnt pathway. Our current efforts are to dissect the cellular drivers of regeneration and to identify Wnt targets which mediate the pro-reparative phenotype.

Project 2

How do stem cells mediate repair and can we develop new bioengineered platforms to improve stem cell-based therapeutics? We have partnered with Vanderbilt Bioengeers to develop stem cell-based treatments for ischemic vascular diseases which seek to understand and optimize both stem cell and scaffold properties which result in improved blood flow restoration.

Project 3

We have developed a mouse model which demonstrates that deletion of a vascular smooth muscle cell protein, SPRR3, results in progression of atherosclerosis and ultimately to its most serious consequence, plaque rupture. Current projects are focused on identifying the molecular partners of SPRR3 and testing it as a novel therapeutic using a novel transgenic mouse as well as state-of-art peptide replacement approaches.

Project 4

As a Transfusion Medicine physician, I am involved in multiple clinical/translational projects involving blood and blood products in clinical medicine.
Research Keywords
We are interested in studying tissue repair and regeneration with a particular focus on stem cells and the cardiovascular system
Clinical Research Keywords
Blood banking, serology, alloimmunization, transfusion practices
Saraswati S, Guo Y, Atkinson J, Young PP. Prolonged hypoxia induces monocarboxylate transporter-4 expression in mesenchymal stem cells resulting in a secretome that is deleterious to cardiovascular repair. Stem Cells. 2015 Apr; 33(4): 1333-44. PMID: 25537659, PMCID: PMC4376598, DOI: 10.1002/stem.1935, ISSN: 1549-4918.

Oakley FD, Woods M, Arnold S, Young PP. Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products. Transfusion [print-electronic]. 2015 Mar; 55(3): 563-70. PMID: 25145580, DOI: 10.1111/trf.12827, ISSN: 1537-2995.

Young PP, Schäfer R. Cell-based therapies for cardiac disease: a cellular therapist's perspective. Transfusion [print-electronic]. 2015 Feb; 55(2): 441-51; quiz 440. PMID: 25145464, DOI: 10.1111/trf.12826, ISSN: 1537-2995.

Segedy AK, Pyle AL, Li B, Zhang Y, Babaev VR, Jat P, Fazio S, Atkinson JB, Linton MF, Young PP. Identification of small proline-rich repeat protein 3 as a novel atheroprotective factor that promotes adaptive Akt signaling in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2014 Dec; 34(12): 2527-36. PMID: 25278290, PMCID: PMC4239161, PII: ATVBAHA.114.303644, DOI: 10.1161/ATVBAHA.114.303644, ISSN: 1524-4636.

Cohen DN, Johnson MS, Liang WH, McDaniel HL, Young PP. Clinically significant hemolytic disease of the newborn secondary to passive transfer of anti-D from maternal RhIG. Transfusion [print-electronic]. 2014 Nov; 54(11): 2863-6. PMID: 24826985, DOI: 10.1111/trf.12698, ISSN: 1537-2995.

West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM. Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension. Am. J. Physiol., Cell Physiol [print-electronic]. 2014 Sep 9/1/2014; 307(5): C415-30. PMID: 24871858, PMCID: PMC4154073, PII: ajpcell.00057.2014, DOI: 10.1152/ajpcell.00057.2014, ISSN: 1522-1563.

Gehrie E, Muranyi A, Walk E, Young PP. Commercially available blood-group antibodies may be used to visualize blood group A antigen in paraffin-embedded tissue sections [letter]. Arch. Pathol. Lab. Med. 2014 Feb; 138(2): 155. PMID: 24476512, DOI: 10.5858/arpa.2013-0302-LE, ISSN: 1543-2165.

Ardestani S, Li B, Deskins DL, Wu H, Massion PP, Young PP. Membrane versus soluble isoforms of TNF-a exert opposing effects on tumor growth and survival of tumor-associated myeloid cells. Cancer Res [print-electronic]. 2013 Jul 7/1/2013; 73(13): 3938-50. PMID: 23704210, PMCID: PMC3702680, PII: 0008-5472.CAN-13-0002, DOI: 10.1158/0008-5472.CAN-13-0002, ISSN: 1538-7445.

Gehrie EA, Cates JM, Nian H, Olson SJ, Young PP. Blood Group A antigen expression on cardiac endothelium is highly individualized: possible implications for transplantation. Cardiovasc. Pathol [print-electronic]. 2013 Jul; 22(4): 251-6. PMID: 23290353, PII: S1054-8807(12)00144-5, DOI: 10.1016/j.carpath.2012.10.007, ISSN: 1879-1336.

Deskins DL, Bastakoty D, Saraswati S, Shinar A, Holt GE, Young PP. Human mesenchymal stromal cells: identifying assays to predict potency for therapeutic selection. Stem Cells Transl Med [print-electronic]. 2013 Feb; 2(2): 151-8. PMID: 23362238, PMCID: PMC3659751, PII: sctm.2012-0099, DOI: 10.5966/sctm.2012-0099, ISSN: 2157-6564.

Ardestani S, Deskins DL, Young PP. Membrane TNF-alpha-activated programmed necrosis is mediated by Ceramide-induced reactive oxygen species. J Mol Signal. 2013; 8(1): 12. PMID: 24180579, PMCID: PMC3895838, PII: 1750-2187-8-12, DOI: 10.1186/1750-2187-8-12, ISSN: 1750-2187.

Gehrie EA, Nian H, Young PP. Brown Recluse spider bite mediated hemolysis: clinical features, a possible role for complement inhibitor therapy, and reduced RBC surface glycophorin A as a potential biomarker of venom exposure. PLoS ONE. 2013; 8(9): e76558. PMID: 24086749, PMCID: PMC3785411, PII: PONE-D-13-24640, DOI: 10.1371/journal.pone.0076558, ISSN: 1932-6203.

Janz DR, Zhao Z, Koyama T, May AK, Bernard GR, Bastarache JA, Young PP, Ware LB. Longer storage duration of red blood cells is associated with an increased risk of acute lung injury in patients with sepsis. Ann Intensive Care. 2013; 3(1): 33. PMID: 24059842, PMCID: PMC3848804, PII: 2110-5820-3-33, DOI: 10.1186/2110-5820-3-33, ISSN: 2110-5820.

Alfaro MP, Deskins DL, Wallus M, DasGupta J, Davidson JM, Nanney LB, A Guney M, Gannon M, Young PP. A physiological role for connective tissue growth factor in early wound healing. Lab. Invest [print-electronic]. 2013 Jan; 93(1): 81-95. PMID: 23212098, PMCID: PMC3720136, PII: labinvest2012162, DOI: 10.1038/labinvest.2012.162, ISSN: 1530-0307.

McClain CM, Hughes J, Andrews JC, Blackburn J, Sephel S, France D, Viele M, Goodnough LT, Young PP. Blood ordering from the operating room: turnaround time as a quality indicator. Transfusion [print-electronic]. 2013 Jan; 53(1): 41-8. PMID: 22536922, DOI: 10.1111/j.1537-2995.2012.03670.x, ISSN: 1537-2995.

Garcia CB, Shaffer CM, Alfaro MP, Smith AL, Sun J, Zhao Z, Young PP, VanSaun MN, Eid JE. Reprogramming of mesenchymal stem cells by the synovial sarcoma-associated oncogene SYT-SSX2. Oncogene [print-electronic]. 2012 May 5/3/2012; 31(18): 2323-34. PMID: 21996728, PMCID: PMC3752676, PII: onc2011418, DOI: 10.1038/onc.2011.418, ISSN: 1476-5594.

Saraswati S, Deskins DL, Holt GE, Young PP. Pyrvinium, a potent small molecule Wnt inhibitor, increases engraftment and inhibits lineage commitment of mesenchymal stem cells (MSCs). Wound Repair Regen [print-electronic]. 2012 Mar; 20(2): 185-93. PMID: 22332749, PMCID: PMC3303160, DOI: 10.1111/j.1524-475X.2012.00767.x, ISSN: 1524-475X.

Gehrie E, Neff AT, Ciombor KK, Harris N, Seegmiller AC, Young PP. Transfusion medicine illustrated. Profound piperacillin-mediated drug-induced immune hemolysis in a patient with cystic fibrosis. Transfusion [print-electronic]. 2012 Jan; 52(1): 4-5. PMID: 22032241, DOI: 10.1111/j.1537-2995.2011.03407.x, ISSN: 1537-2995.

Deskins DL, Ardestani S, Young PP. The polyvinyl alcohol sponge model implantation. J Vis Exp. 2012; (62): PMID: 22546933, PMCID: PMC3466653, PII: 3885, DOI: 10.3791/3885, ISSN: 1940-087X.

Hughey CC, Alfaro MP, Belke DD, Rottman JN, Young PP, Wasserman DH, Shearer J. Increased oxygen consumption and OXPHOS potential in superhealer mesenchymal stem cells. Cell Regen (Lond). 2012; 1(1): 3. PMID: 25408866, PMCID: PMC4230749, PII: 3, DOI: 10.1186/2045-9769-1-3, ISSN: 2045-9769.

Alfaro MP, Young PP. Lessons from genetically altered mesenchymal stem cells (MSCs): candidates for improved MSC-directed myocardial repair. Cell Transplant [print-electronic]. 2012; 21(6): 1065-74. PMID: 22080676, PII: ct0433alfaro, DOI: 10.3727/096368911X612477, ISSN: 1555-3892.

Young PP, Cotton BA, Goodnough LT. Massive transfusion protocols for patients with substantial hemorrhage. Transfus Med Rev [print-electronic]. 2011 Oct; 25(4): 293-303. PMID: 21664104, PMCID: PMC3176940, PII: S0887-7963(11)00031-9, DOI: 10.1016/j.tmrv.2011.04.002, ISSN: 1532-9496.

Li B, Pozzi A, Young PP. TNFalpha accelerates monocyte to endothelial transdifferentiation in tumors by the induction of integrin alpha5 expression and adhesion to fibronectin. Mol. Cancer Res [print-electronic]. 2011 Jun; 9(6): 702-11. PMID: 21536688, PMCID: PMC3157289, PII: 1541-7786.MCR-10-0484, DOI: 10.1158/1541-7786.MCR-10-0484, ISSN: 1557-3125.

O'Leary MF, Szklarski P, Klein TM, Young PP. Hemolysis of red blood cells after cell washing with different automated technologies: clinical implications in a neonatal cardiac surgery population. Transfusion [print-electronic]. 2011 May; 51(5): 955-60. PMID: 21091957, DOI: 10.1111/j.1537-2995.2010.02935.x, ISSN: 1537-2995.

Alfaro MP, Saraswati S, Young PP. Molecular mediators of mesenchymal stem cell biology. Vitam. Horm. 2011; 87: 39-59. PMID: 22127236, PII: B978-0-12-386015-6.00023-8, DOI: 10.1016/B978-0-12-386015-6.00023-8, ISSN: 0083-6729.

Alfaro MP, Vincent A, Saraswati S, Thorne CA, Hong CC, Lee E, Young PP. SFRP2 suppression of bone morphogenic protein (BMP) and Wnt signaling mediates mesenchymal stem cell (MSC) self-renewal promoting engraftment and myocardial repair. J. Biol. Chem [print-electronic]. 2010 Nov 11/12/2010; 285(46): 35645-53. PMID: 20826809, PMCID: PMC2975189, PII: M110.135335, DOI: 10.1074/jbc.M110.135335, ISSN: 1083-351X.

Cates JM, Friedman DB, Seeley EH, Dupont WD, Schwartz HS, Holt GE, Caprioli RM, Young PP. Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis. Int J Exp Pathol [print-electronic]. 2010 Aug; 91(4): 335-49. PMID: 20353421, PMCID: PMC2962892, PII: IEP711, DOI: 10.1111/j.1365-2613.2010.00711.x, ISSN: 1365-2613.

Cotton BA, Dossett LA, Haut ER, Shafi S, Nunez TC, Au BK, Zaydfudim V, Johnston M, Arbogast P, Young PP. Multicenter validation of a simplified score to predict massive transfusion in trauma. J Trauma. 2010 Jul; 69 Suppl 1: S33-9. PMID: 20622617, PII: 00005373-201007001-00006, DOI: 10.1097/TA.0b013e3181e42411, ISSN: 1529-8809.

Pyle AL, Young PP. Atheromas feel the pressure: biomechanical stress and atherosclerosis. Am. J. Pathol [print-electronic]. 2010 Jul; 177(1): 4-9. PMID: 20558573, PMCID: PMC2893643, PII: S0002-9440(10)60056-9, DOI: 10.2353/ajpath.2010.090615, ISSN: 1525-2191.

Pyle AL, Li B, Maupin AB, Guzman RJ, Crimmins DL, Olson S, Atkinson JB, Young PP. Biomechanical stress induces novel arterial intima-enriched genes: implications for vascular adaptation to stress. Cardiovasc. Pathol [print-electronic]. 2010 Mar; 19(2): e13-20. PMID: 19211270, PII: S1054-8807(08)00187-7, DOI: 10.1016/j.carpath.2008.12.006, ISSN: 1879-1336.

Saraswati S, Alfaro MP, Thorne CA, Atkinson J, Lee E, Young PP. Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling. PLoS ONE. 2010; 5(11): e15521. PMID: 21170416, PMCID: PMC2993965, DOI: 10.1371/journal.pone.0015521, ISSN: 1932-6203.

Au BK, Dutton WD, Zaydfudim V, Nunez TC, Young PP, Cotton BA. Hyperkalemia following massive transfusion in trauma. J. Surg. Res [print-electronic]. 2009 Dec; 157(2): 284-9. PMID: 19765727, PII: S0022-4804(09)00266-2, DOI: 10.1016/j.jss.2009.05.009, ISSN: 1095-8673.

Barnes SL, Young PP, Miga MI. A novel model-gel-tissue assay analysis for comparing tumor elastic properties to collagen content. Biomech Model Mechanobiol [print-electronic]. 2009 Aug; 8(4): 337-43. PMID: 19308472, DOI: 10.1007/s10237-009-0150-9, ISSN: 1617-7940.

Cotton BA, Au BK, Nunez TC, Gunter OL, Robertson AM, Young PP. Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. J Trauma. 2009 Jan; 66(1): 41-8; discussion 48. PMID: 19131804, PII: 00005373-200901000-00005, DOI: 10.1097/TA.0b013e31819313bb, ISSN: 1529-8809.

Li B, Vincent A, Cates J, Brantley-Sieders DM, Polk DB, Young PP. Low levels of tumor necrosis factor alpha increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site. Cancer Res. 2009 Jan 1/1/2009; 69(1): 338-48. PMID: 19118019, PMCID: PMC2651676, PII: 69/1/338, DOI: 10.1158/0008-5472.CAN-08-1565, ISSN: 1538-7445.

Pyle AL, Li B, Maupin AB, Guzman RJ, Crimmins DL, Olson S, Atkinson JB and Young PP.. Biomechanical stress induces novel arterial intima-enriched genes: implications for vascular adaptation to stress. Cardiovasc Pathol. 2009; in press.

Li B, Vincent A, Cates J, Brantley-Sieders, D, Polk DB, Young PP. Low levels of TNF increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site. Cancer Res. 2009; in press.

Alfaro MP, Pagni M, Vincent A, Atkinson J, Hill MF, Cates J, Davidson JM, Rottman J, Lee E, Young PP. The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2008 Nov 11/25/2008; 105(47): 18366-71. PMID: 19017790, PMCID: PMC2587631, PII: 0803437105, DOI: 10.1073/pnas.0803437105, ISSN: 1091-6490.

Pyle AL, Atkinson JB, Pozzi A, Reese J, Eckes B, Davidson JM, Crimmins DL, Young PP. Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction. Am. J. Pathol [print-electronic]. 2008 Nov; 173(5): 1577-88. PMID: 18832573, PMCID: PMC2570146, PII: S0002-9440(10)61542-8, DOI: 10.2353/ajpath.2008.080042, ISSN: 1525-2191.

Gunter OL, Au BK, Isbell JM, Mowery NT, Young PP, Cotton BA. Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survival. J Trauma. 2008 Sep; 65(3): 527-34. PMID: 18784564, PII: 00005373-200809000-00004, DOI: 10.1097/TA.0b013e3181826ddf, ISSN: 1529-8809.

Cotton BA, Gunter OL, Isbell J, Au BK, Robertson AM, Morris JA, St Jacques P, Young PP. Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization. J Trauma. 2008 May; 64(5): 1177-82; discussion 1182. PMID: 18469638, PII: 00005373-200805000-00005, DOI: 10.1097/TA.0b013e31816c5c80, ISSN: 1529-8809.

Ryzhov S, Solenkova NV, Goldstein AE, Lamparter M, Fleenor T, Young PP, Greelish JP, Byrne JG, Vaughan DE, Biaggioni I, Hatzopoulos AK, Feoktistov I. Adenosine receptor-mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cells. Circ. Res [print-electronic]. 2008 Feb 2/15/2008; 102(3): 356-63. PMID: 18032734, PMCID: PMC2803108, PII: CIRCRESAHA.107.158147, DOI: 10.1161/CIRCRESAHA.107.158147, ISSN: 1524-4571.

Devin JK, Vaughan DE, Blevins LS, Chen Q, Covington J, Verity DK, and Young PP. Low-dose growth hormone administration mobilizes endothelial progenitor cells in healthy adults. Growth Hormone and IGF Res. 2008; 9: 983-92.

Alfaro MP, Pagni M, Vincent A, Atkinson J, Hill MF, Cates J, Davidson JM, Rottman J, Lee E, and Young PP.. A Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair. Proc. Natl. Acad. Sci. , USA, Track 2. 2008; in press.

Santoro SA, Mosse CA, Young PP. The MD/PhD pathway to a career in laboratory medicine. Clin. Lab. Med. 2007 Jun; 27(2): 425-34; abstract ix. PMID: 17556094, PII: S0272-2712(07)00028-5, DOI: 10.1016/j.cll.2007.03.012, ISSN: 0272-2712.

Young PP, Vaughan DE, Hatzopoulos AK. Biologic properties of endothelial progenitor cells and their potential for cell therapy. Prog Cardiovasc Dis. 2007 May; 49(6): 421-9. PMID: 17498522, PMCID: PMC1978244, PII: S0033-0620(07)00023-0, DOI: 10.1016/j.pcad.2007.02.004, ISSN: 0033-0620.

Li B, Sharpe EE, Maupin AB, Teleron AA, Pyle AL, Carmeliet P, Young PP. VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization. FASEB J [print-electronic]. 2006 Jul; 20(9): 1495-7. PMID: 16754748, PII: fj.05-5137fje, DOI: 10.1096/fj.05-5137fje, ISSN: 1530-6860.

Sharpe EE, Teleron AA, Li B, Price J, Sands MS, Alford K, Young PP. The origin and in vivo significance of murine and human culture-expanded endothelial progenitor cells. Am. J. Pathol. 2006 May; 168(5): 1710-21. PMID: 16651636, PMCID: PMC1606589, PII: S0002-9440(10)62192-X, DOI: 10.2353/ajpath.2006.050556, ISSN: 0002-9440.

Young PP, Modur V, Teleron AA, Ladenson JH. Enrichment of genes in the aortic intima that are associated with stratified epithelium: implications of underlying biomechanical and barrier properties of the arterial intima. Circulation [print-electronic]. 2005 May 5/10/2005; 111(18): 2382-90. PMID: 15867175, PII: 01.CIR.0000164235.26339.78, DOI: 10.1161/01.CIR.0000164235.26339.78, ISSN: 1524-4539.

Teleron AA, Carlson B, Young PP. Blood donor white blood cell reduction filters as a source of human peripheral blood-derived endothelial progenitor cells. Transfusion. 2005 Jan; 45(1): 21-5. PMID: 15647014, PII: TRF04191, DOI: 10.1111/j.1537-2995.2005.04191.x, ISSN: 0041-1132.

Young PP, Fantz CR, Sands MS. VEGF disrupts the neonatal blood-brain barrier and increases life span after non-ablative BMT in a murine model of congenital neurodegeneration caused by a lysosomal enzyme deficiency. Exp. Neurol. 2004 Jul; 188(1): 104-14. PMID: 15191807, PII: S0014488604000962, DOI: 10.1016/j.expneurol.2004.03.007, ISSN: 0014-4886.

Alcorn JL, Islam KN, Young PP, Mendelson CR. Glucocorticoid inhibition of SP-A gene expression in lung type II cells is mediated via the TTF-1-binding element. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2004 Apr; 286(4): L767-76. PMID: 14633512, PII: 00280.2003, DOI: 10.1152/ajplung.00280.2003, ISSN: 1040-0605.

Young PP, Uzieblo A, Trulock E, Lublin DM, Goodnough LT. Autoantibody formation after alloimmunization: are blood transfusions a risk factor for autoimmune hemolytic anemia?. Transfusion. 2004 Jan; 44(1): 67-72. PMID: 14692969, ISSN: 0041-1132.

Young PP, Vogler C, Hofling AA, Sands MS. Biodistribution and efficacy of donor T lymphocytes in a murine model of lysosomal storage disease. Mol. Ther. 2003 Jan; 7(1): 52-61. PMID: 12573618, PII: S1525001602000205, ISSN: 1525-0016.

Young PP, Hofling AA, Sands MS. VEGF increases engraftment of bone marrow-derived endothelial progenitor cells (EPCs) into vasculature of newborn murine recipients. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2002 Sep 9/3/2002; 99(18): 11951-6. PMID: 12195016, PMCID: PMC129375, PII: 182215799, DOI: 10.1073/pnas.182215799, ISSN: 0027-8424.

Young PP, Goodnough LT, Westervelt P, Diersio JF. Immune hemolysis involving non-ABO/RhD alloantibodies following hematopoietic stem cell transplantation. Bone Marrow Transplant. 2001 Jun; 27(12): 1305-10. PMID: 11548850, ISSN: 0268-3369.

Young PP, Buller RS, Storch GA. Evaluation of a commercial DNA enzyme immunoassay for detection of enterovirus reverse transcription-PCR products amplified from cerebrospinal fluid specimens. J. Clin. Microbiol. 2000 Nov; 38(11): 4260-1. PMID: 11060104, PMCID: PMC87577, ISSN: 0095-1137.

Mendelson CR, Gao E, Li J, Young PP, Michael LF, Alcorn JL. Regulation of expression of surfactant protein-A. Biochim. Biophys. Acta. 1998 Nov 11/19/1998; 1408(2-3): 132-49. PMID: 9813283, PII: S0925-4439(98)00063-5, ISSN: 0006-3002.

Young PP, Mendelson CR. A GT box element is essential for basal and cyclic adenosine 3',5'-monophosphate regulation of the human surfactant protein A2 gene in alveolar type II cells: evidence for the binding of lung nuclear factors distinct from Sp1. Mol. Endocrinol. 1997 Jul; 11(8): 1082-93. PMID: 9212056, DOI: 10.1210/mend.11.8.9950, ISSN: 0888-8809.

Mendelson CR, Gao E, Young PP, Michael LF, Alcorn JL. Transcriptional regulation of the surfactant protein-A gene in fetal lung. Chest. 1997 Jun; 111(6 Suppl): 96S-104S. PMID: 9184549, ISSN: 0012-3692.

Young PP, Mendelson CR. A CRE-like element plays an essential role in cAMP regulation of human SP-A2 gene in alveolar type II cells. Am. J. Physiol. 1996 Aug; 271(2 Pt 1): L287-99. PMID: 8770068, ISSN: 0002-9513.

Available Postdoctoral Position Details
Posted: 1/30/2015
A scientist with molecular biology and biochemistry experience desired with interest in stem cell biology. References required.