Richard M. Peek, Jr., M.D.

Professor

richard.peek@vanderbilt.edu

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Faculty Appointments
Director, Division of Gastroenterology Professor of Medicine Professor of Pathology, Microbiology and ImmunologyProfessor of Cancer BiologyMina Cobb Wallace Chair in Immunology
Education
M.D., Medicine, University of North Carolina, Chapel Hill, North CarolinaB.S., Pre-Medicine, Davidson College, Davidson, North Carolina
Office Address
1030C MRB IV (0252)
2215B Garland Avenue
Nashville, TN 37232-0252
Research Description
The gastrointestinal tract is a dynamic interactive barrier that normally segregates microbial populations from their cognate human hosts. An aberrant consequence of contact between microbes and gut epithelial cells is the development of mucosal inflammation, which, if allowed to become persistent, can initiate carcinogenic pathways. Gastric adenocarcinoma is the second leading cause of cancer-related death in the world, and Helicobacter pylori, a bacterial species that persistently colonizes the human stomach and induces chronic gastritis, is the strongest known risk factor for this malignancy. However, only a fraction of infected persons ever develop cancer, underscoring the importance of defining mechanisms that regulate the biological interactions of H. pylori with their hosts that promote neoplastic transformation. Adherence of H. pylori to gastric epithelial cells is critical for induction of inflammation and injury; therefore, the overarching theme for our research has been delineation of the molecular signaling events initiated by bacterial:epithelial cell contact that regulate phenotypes related to carcinogenesis.

The most important known H. pylori strain-specific determinant associated with cancer is the cag pathogenicity island, and cag+ strains augment the risk for severe gastritis and gastric cancer. Using in vitro models of bacterial:gastric epithelial cell interactions, we have shown that cag island genes are required for pro-inflammatory cytokine release and induction of apoptosis, and that these events are mediated by activation of NF-kB and/or mitogen-activated protein kinases (MAPK). Recently, we have used global proteomics approaches to identify additional H. pylori products that are related to pathogenesis within the gastric niche. Extending these results into rodent models of H. pylori-induced inflammation and carcinogenesis (Mongolian gerbils and mice), we have shown that inactivation of such genes attenuates the development gastric injury and cancer.

In human gastric tissue, however, gastric epithelial cell proliferation is significantly higher but apoptotic indices are lower among persons colonized with cag+ compared to cag- strains or uninfected persons leading us to postulate that reduced rates of cell loss, when accompanied by hyperproliferation, may heighten retention of mutagenized cells, which could predispose towards cancer. Therefore, we have also focused our investigations on host determinants that influence disease outcomes occurring within the context of H. pylori infection. One host effector that may influence carcinogenesis in response to H. pylori is MMP-7, a matrix metalloproteinase that enhances tumor formation in rodents, and is over-expressed in premalignant and malignant lesions within H. pylori-infected human mucosa. Although epithelial cells acutely exposed to matrilysin rapidly undergo apoptosis, constitutive expression of MMP-7 selects for cells with a reduced sensitivity to apoptosis. Our experiments have recently shown that MMP-7 is detected exclusively in human mucosa colonized by cag+ strains, and these same H. pylori strains selectively induce MMP-7 in vitro through cag-mediated activation of NF-kB and MAPK. Based upon these data, we hypothesize that strain-selective activation of NF-kB and/or MAPK by H. pylori cag+ strains regulates MMP-7 expression, which may contribute to the augmentation in carcinogenic risk associated with these strains by attenuating apoptosis within chronically colonized mucosa.

We have also recently shown that carcinogenic strains of H. pylori can selectively activate B-catenin, and this is due to translocation of CagA into the host epithelial cell. Our current studies therefore, are not only allowing us to investigate discrete interactions that lead to H. pylori-induced neoplasias but also are providing mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.
Research Keywords
Pathogenesis, Helicobacter pylori, gastric cancer, carcinogenesis, infectious disease, bacterial pathogenesis, inflammation, malignancy
Publications
Wroblewski LE, Peek RM. Helicobacter pylori: Pathogenic enablers - toxic relationships in the stomach. Nat Rev Gastroenterol Hepatol [print-electronic]. 2016 Jun; 13(6): 317-8. PMID: 27147493, PII: nrgastro.2016.68, DOI: 10.1038/nrgastro.2016.68, ISSN: 1759-5053.

Corley DA, Peek RM. The Dawning of a New Editorial Board for Gastroenterology. Gastroenterology [print-electronic]. 2016 May 5/20/2016; PMID: 27215655, PII: S0016-5085(16)34451-1, DOI: 10.1053/j.gastro.2016.05.008, ISSN: 1528-0012.

Chen J, Wang Z, Hu X, Chen R, Romero-Gallo J, Peek RM, Chen LF. BET Inhibition Attenuates Helicobacter pylori-Induced Inflammatory Response by Suppressing Inflammatory Gene Transcription and Enhancer Activation. J. Immunol [print-electronic]. 2016 May 5/15/2016; 196(10): 4132-42. PMID: 27084101, PMCID: PMC4868794, PII: jimmunol.1502261, DOI: 10.4049/jimmunol.1502261, ISSN: 1550-6606.

Krishna U, Romero-Gallo J, Suarez G, Azah A, Krezel AM, Varga MG, Forsyth MH, Peek RM. Genetic Evolution of a Helicobacter pylori Acid-Sensing Histidine Kinase and Gastric Disease. J. Infect. Dis [print-electronic]. 2016 May 5/10/2016; PMID: 27190191, PII: jiw189, DOI: 10.1093/infdis/jiw189, ISSN: 1537-6613.

Varga MG, Shaffer CL, Sierra JC, Suarez G, Piazuelo MB, Whitaker ME, Romero-Gallo J, Krishna US, Delgado A, Gomez MA, Good JA, Almqvist F, Skaar EP, Correa P, Wilson KT, Hadjifrangiskou M, Peek RM. Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system. Oncogene [print-electronic]. 2016 May 5/9/2016; PMID: 27157617, PII: onc2016158, DOI: 10.1038/onc.2016.158, ISSN: 1476-5594.

Riquelme I, Tapia O, Espinoza JA, Leal P, Buchegger K, Sandoval A, Bizama C, Araya JC, Peek RM, Roa JC. The Gene Expression Status of the PI3K/AKT/mTOR Pathway in Gastric Cancer Tissues and Cell Lines. Pathol. Oncol. Res [print-electronic]. 2016 May 5/7/2016; PMID: 27156070, PII: 10.1007/s12253-016-0066-5, DOI: 10.1007/s12253-016-0066-5, ISSN: 1532-2807.

Shimizu T, Choi E, Petersen CP, Noto JM, Romero-Gallo J, Piazuelo MB, Washington MK, Peek RM, Goldenring JR. Characterization of progressive metaplasia in the gastric corpus mucosa of Mongolian gerbils infected with Helicobacter pylori. J. Pathol [print-electronic]. 2016 Apr 4/29/2016; PMID: 27125972, DOI: 10.1002/path.4735, ISSN: 1096-9896.

Yan F, Liu L, Cao H, Moore DJ, Washington MK, Wang B, Peek RM, Acra SA, Polk DB. Neonatal colonization of mice with LGG promotes intestinal development and decreases susceptibility to colitis in adulthood. Mucosal Immunol [print-electronic]. 2016 Apr 4/20/2016; PMID: 27095077, PII: mi201643, DOI: 10.1038/mi.2016.43, ISSN: 1935-3456.

Amieva M, Peek RM. Pathobiology of Helicobacter pylori-Induced Gastric Cancer. Gastroenterology [print-electronic]. 2016 Jan; 150(1): 64-78. PMID: 26385073, PMCID: PMC4691563, PII: S0016-5085(15)01312-8, DOI: 10.1053/j.gastro.2015.09.004, ISSN: 1528-0012.

Yang I, Woltemate S, Piazuelo MB, Bravo LE, Yepez MC, Romero-Gallo J, Delgado AG, Wilson KT, Peek RM, Correa P, Josenhans C, Fox JG, Suerbaum S. Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia. Sci Rep. 2016; 6: 18594. PMID: 26729566, PMCID: PMC4700446, PII: srep18594, DOI: 10.1038/srep18594, ISSN: 2045-2322.

Noto JM, Romero-Gallo J, Piazuelo MB, Peek RM. The Mongolian Gerbil: A Robust Model of Helicobacter pylori-Induced Gastric Inflammation and Cancer. Methods Mol. Biol. 2016; 1422: 263-80. PMID: 27246040, DOI: 10.1007/978-1-4939-3603-8_24, ISSN: 1940-6029.

Moore BD, Jin RU, Osaki L, Romero-Gallo J, Noto J, Peek RM, Mills JC. Identification of alanyl aminopeptidase (CD13) as a surface marker for isolation of mature gastric zymogenic chief cells. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2015 Dec 12/15/2015; 309(12): G955-64. PMID: 26514774, PMCID: PMC4683299, PII: ajpgi.00261.2015, DOI: 10.1152/ajpgi.00261.2015, ISSN: 1522-1547.

Soutto M, Chen Z, Katsha AM, Romero-Gallo J, Krishna US, Piazuelo MB, Washington MK, Peek RM, Belkhiri A, El-Rifai WM. Trefoil factor 1 expression suppresses Helicobacter pylori-induced inflammation in gastric carcinogenesis. Cancer [print-electronic]. 2015 Dec 12/15/2015; 121(24): 4348-58. PMID: 26372254, PMCID: PMC4670586, DOI: 10.1002/cncr.29644, ISSN: 1097-0142.

Xiong M, Lee MW, Mansbach RA, Song Z, Bao Y, Peek RM, Yao C, Chen LF, Ferguson AL, Wong GC, Cheng J. Helical antimicrobial polypeptides with radial amphiphilicity. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2015 Oct 10/27/2015; 112(43): 13155-60. PMID: 26460016, PMCID: PMC4629321, PII: 1507893112, DOI: 10.1073/pnas.1507893112, ISSN: 1091-6490.

Riquelme I, Tapia O, Leal P, Sandoval A, Varga MG, Letelier P, Buchegger K, Bizama C, Espinoza JA, Peek RM, Araya JC, Roa JC. MiR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway. Cell Oncol (Dordr) [print-electronic]. 2015 Oct 10/12/2015; PMID: 26458815, PII: 10.1007/s13402-015-0247-3, DOI: 10.1007/s13402-015-0247-3, ISSN: 2211-3436.

Schneider BG, Mera R, Piazuelo MB, Bravo JC, Zabaleta J, Delgado AG, Bravo LE, Wilson KT, El-Rifai W, Peek RM, Correa P. DNA Methylation Predicts Progression of Human Gastric Lesions. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2015 Oct; 24(10): 1607-13. PMID: 26269563, PMCID: PMC4592454, PII: 1055-9965.EPI-15-0388, DOI: 10.1158/1055-9965.EPI-15-0388, ISSN: 1538-7755.

Noto MJ, Boyd KL, Burns WJ, Varga MG, Peek RM, Skaar EP. Toll-Like Receptor 9 Contributes to Defense against Acinetobacter baumannii Infection. Infect. Immun [print-electronic]. 2015 Oct; 83(10): 4134-41. PMID: 26238713, PMCID: PMC4567622, PII: IAI.00410-15, DOI: 10.1128/IAI.00410-15, ISSN: 1098-5522.

Noto JM, Peek RM. Micronutrients: A double-edged sword in microbial-induced gastric carcinogenesis. Trends Cancer. 2015 Oct 10/1/2015; 1(2): 136-44. PMID: 26623443, PMCID: PMC4662415, DOI: 10.1016/j.trecan.2015.07.002, ISSN: 2405-8033.

Zaika AI, Wei J, Noto JM, Peek RM. Microbial Regulation of p53 Tumor Suppressor. PLoS Pathog. 2015 Sep; 11(9): e1005099. PMID: 26379246, PMCID: PMC4574736, PII: PPATHOGENS-D-15-01283, DOI: 10.1371/journal.ppat.1005099, ISSN: 1553-7374.

Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM, Abumrad NN, Flynn CR. Hepatic TLR4 signaling in obese NAFLD. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2015 Aug 8/15/2015; 309(4): G270-8. PMID: 26113297, PMCID: PMC4537925, PII: ajpgi.00304.2014, DOI: 10.1152/ajpgi.00304.2014, ISSN: 1522-1547.

Hammond CE, Beeson C, Suarez G, Peek RM, Backert S, Smolka AJ. Helicobacter pylori virulence factors affecting gastric proton pump expression and acid secretion. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2015 Aug 8/1/2015; 309(3): G193-201. PMID: 26045613, PMCID: PMC4525105, PII: ajpgi.00099.2015, DOI: 10.1152/ajpgi.00099.2015, ISSN: 1522-1547.

Soutto M, Romero-Gallo J, Krishna U, Piazuelo MB, Washington MK, Belkhiri A, Peek RM, El-Rifai W. Loss of TFF1 promotes Helicobacter pylori-induced ß-catenin activation and gastric tumorigenesis. Oncotarget. 2015 Jul 7/20/2015; 6(20): 17911-22. PMID: 25980439, PMCID: PMC4627225, PII: 3772, DOI: 10.18632/oncotarget.3772, ISSN: 1949-2553.

Wei J, Noto JM, Zaika E, Romero-Gallo J, Piazuelo MB, Schneider B, El-Rifai W, Correa P, Peek RM, Zaika AI. Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner. Gut [print-electronic]. 2015 Jul; 64(7): 1040-8. PMID: 25080447, PMCID: PMC4312278, PII: gutjnl-2014-307295, DOI: 10.1136/gutjnl-2014-307295, ISSN: 1468-3288.

Noto JM, Lee JY, Gaddy JA, Cover TL, Amieva MR, Peek RM. Regulation of Helicobacter pylori Virulence Within the Context of Iron Deficiency. J. Infect. Dis [print-electronic]. 2015 Jun 6/1/2015; 211(11): 1790-4. PMID: 25505301, PMCID: PMC4447831, PII: jiu805, DOI: 10.1093/infdis/jiu805, ISSN: 1537-6613.

Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM, Fox JG, Woster PM, Casero RA, Correa P, Wilson KT. Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene [print-electronic]. 2015 Jun; 34(26): 3429-40. PMID: 25174398, PMCID: PMC4345146, PII: onc2014273, DOI: 10.1038/onc.2014.273, ISSN: 1476-5594.

Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut [print-electronic]. 2015 May; 64(5): 720-30. PMID: 25123931, PMCID: PMC4329117, PII: gutjnl-2014-307650, DOI: 10.1136/gutjnl-2014-307650, ISSN: 1468-3288.

Suarez G, Romero-Gallo J, Piazuelo MB, Wang G, Maier RJ, Forsberg LS, Azadi P, Gomez MA, Correa P, Peek RM. Modification of Helicobacter pylori Peptidoglycan Enhances NOD1 Activation and Promotes Cancer of the Stomach. Cancer Res [print-electronic]. 2015 Apr 4/15/2015; 75(8): 1749-59. PMID: 25732381, PMCID: PMC4401661, PII: 0008-5472.CAN-14-2291, DOI: 10.1158/0008-5472.CAN-14-2291, ISSN: 1538-7445.

Krakowiak MS, Noto JM, Piazuelo MB, Hardbower DM, Romero-Gallo J, Delgado A, Chaturvedi R, Correa P, Wilson KT, Peek RM. Matrix metalloproteinase 7 restrains Helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarization. Oncogene [print-electronic]. 2015 Apr 4/2/2015; 34(14): 1865-71. PMID: 24837365, PMCID: PMC4237684, PII: onc2014135, DOI: 10.1038/onc.2014.135, ISSN: 1476-5594.

Bertaux-Skeirik N, Feng R, Schumacher MA, Li J, Mahe MM, Engevik AC, Javier JE, Peek RM, Ottemann K, Orian-Rousseau V, Boivin GP, Helmrath MA, Zavros Y. CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation. PLoS Pathog. 2015 Feb; 11(2): e1004663. PMID: 25658601, PMCID: PMC4450086, PII: PPATHOGENS-D-14-02175, DOI: 10.1371/journal.ppat.1004663, ISSN: 1553-7374.

Bhardwaj V, Noto JM, Wei J, Andl C, El-Rifai W, Peek RM, Zaika AI. Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway. Oncotarget. 2015 Jan 1/30/2015; 6(3): 1531-43. PMID: 25605238, PMCID: PMC4359312, PII: 2828, DOI: 10.18632/oncotarget.2828, ISSN: 1949-2553.

Kim A, Servetas SL, Kang J, Kim J, Jang S, Cha HJ, Lee WJ, Kim J, Romero-Gallo J, Peek RM, Merrell DS, Cha JH. Helicobacter pylori bab Paralog Distribution and Association with cagA, vacA, and homA/B Genotypes in American and South Korean Clinical Isolates. PLoS ONE. 2015; 10(8): e0137078. PMID: 26317221, PMCID: PMC4552749, PII: PONE-D-15-19634, DOI: 10.1371/journal.pone.0137078, ISSN: 1932-6203.

Asim M, Chikara SK, Ghosh A, Vudathala S, Romero-Gallo J, Krishna US, Wilson KT, Israel DA, Peek RM, Chaturvedi R. Draft Genome Sequence of Gerbil-Adapted Carcinogenic Helicobacter pylori Strain 7.13. Genome Announc. 2015; 3(3): PMID: 26067974, PMCID: PMC4463538, PII: 3/3/e00641-15, DOI: 10.1128/genomeA.00641-15, ISSN: 2169-8287.

Gaddy JA, Radin JN, Loh JT, Piazuelo MB, Kehl-Fie TE, Delgado AG, Ilca FT, Peek RM, Cover TL, Chazin WJ, Skaar EP, Scott Algood HM. The host protein calprotectin modulates the Helicobacter pylori cag type IV secretion system via zinc sequestration. PLoS Pathog. 2014 Oct; 10(10): e1004450. PMID: 25330071, PMCID: PMC4199781, PII: PPATHOGENS-D-14-01130, DOI: 10.1371/journal.ppat.1004450, ISSN: 1553-7374.

Gobert AP, Verriere T, Asim M, Barry DP, Piazuelo MB, de Sablet T, Delgado AG, Bravo LE, Correa P, Peek RM, Chaturvedi R, Wilson KT. Heme oxygenase-1 dysregulates macrophage polarization and the immune response to Helicobacter pylori. J. Immunol [print-electronic]. 2014 Sep 9/15/2014; 193(6): 3013-22. PMID: 25108023, PMCID: PMC4171064, PII: jimmunol.1401075, DOI: 10.4049/jimmunol.1401075, ISSN: 1550-6606.

Hardbower DM, Peek RM, Wilson KT. At the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer. J. Leukoc. Biol [print-electronic]. 2014 Aug; 96(2): 201-12. PMID: 24868089, PMCID: PMC4101087, PII: jlb.4BT0214-099R, DOI: 10.1189/jlb.4BT0214-099R, ISSN: 1938-3673.

Chaturvedi R, Asim M, Piazuelo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA, Bravo LE, Dominguez RL, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Morgan DR, Peek RM, Wilson KT. Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage. Gastroenterology [print-electronic]. 2014 Jun; 146(7): 1739-51.e14. PMID: 24530706, PMCID: PMC4035375, PII: S0016-5085(14)00192-9, DOI: 10.1053/j.gastro.2014.02.005, ISSN: 1528-0012.

Abreu MT, Peek RM. Gastrointestinal malignancy and the microbiome. Gastroenterology [print-electronic]. 2014 May; 146(6): 1534-1546.e3. PMID: 24406471, PMCID: PMC3995897, PII: S0016-5085(14)00003-1, DOI: 10.1053/j.gastro.2014.01.001, ISSN: 1528-0012.

Suarez G, Peek RM. Helicobacter pylori: expect the unexpected. Mol. Microbiol [print-electronic]. 2014 Mar; 91(5): 858-61. PMID: 24471732, PMCID: PMC3966957, DOI: 10.1111/mmi.12532, ISSN: 1365-2958.

Epplein M, Peek RM, Blot WJ. Helicobacter pylori Biomarkers and Risk of Colorectal Oncogenesis--Response [letter]. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2014 Feb; 23(2): 366. PMID: 24285842, PMCID: PMC3946073, PII: 1055-9965.EPI-13-1191, DOI: 10.1158/1055-9965.EPI-13-1191, ISSN: 1538-7755.

Kodaman N, Pazos A, Schneider BG, Piazuelo MB, Mera R, Sobota RS, Sicinschi LA, Shaffer CL, Romero-Gallo J, de Sablet T, Harder RH, Bravo LE, Peek RM, Wilson KT, Cover TL, Williams SM, Correa P. Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2014 Jan 1/28/2014; 111(4): 1455-60. PMID: 24474772, PMCID: PMC3910595, PII: 1318093111, DOI: 10.1073/pnas.1318093111, ISSN: 1091-6490.

Epplein M, Zheng W, Li H, Peek RM, Correa P, Gao J, Michel A, Pawlita M, Cai Q, Xiang YB, Shu XO. Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men. Nutr Cancer [print-electronic]. 2014; 66(4): 550-7. PMID: 24666234, PMCID: PMC4068395, DOI: 10.1080/01635581.2014.894096, ISSN: 1532-7914.

Noto JM, Piazuelo MB, Chaturvedi R, Bartel CA, Thatcher EJ, Delgado A, Romero-Gallo J, Wilson KT, Correa P, Patton JG, Peek RM. Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2013 Dec; 305(11): G786-96. PMID: 24136787, PMCID: PMC3882435, PII: ajpgi.00279.2013, DOI: 10.1152/ajpgi.00279.2013, ISSN: 1522-1547.

Epplein M, Xiang YB, Cai Q, Peek RM, Li H, Correa P, Gao J, Wu J, Michel A, Pawlita M, Zheng W, Shu XO. Circulating cytokines and gastric cancer risk. Cancer Causes Control [print-electronic]. 2013 Dec; 24(12): 2245-50. PMID: 24052422, PMCID: PMC3828746, DOI: 10.1007/s10552-013-0284-z, ISSN: 1573-7225.

Epplein M, Pawlita M, Michel A, Peek RM, Cai Q, Blot WJ. Helicobacter pylori protein-specific antibodies and risk of colorectal cancer. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2013 Nov; 22(11): 1964-74. PMID: 24045925, PMCID: PMC3828745, PII: 1055-9965.EPI-13-0702, DOI: 10.1158/1055-9965.EPI-13-0702, ISSN: 1538-7755.

Schneider BG, Piazuelo MB, Sicinschi LA, Mera R, Peng DF, Roa JC, Romero-Gallo J, Delgado AG, de Sablet T, Bravo LE, Wilson KT, El-Rifai W, Peek RM, Correa P. Virulence of infecting Helicobacter pylori strains and intensity of mononuclear cell infiltration are associated with levels of DNA hypermethylation in gastric mucosae. Epigenetics [print-electronic]. 2013 Nov; 8(11): 1153-61. PMID: 24128875, PMCID: PMC3927747, PII: 26072, DOI: 10.4161/epi.26072, ISSN: 1559-2308.

Peek RM. Introduction. Helicobacter pylori [editorial]. Gut Microbes [print-electronic]. 2013 Nov; 4(6): 425. PMID: 24262863, PMCID: PMC3928155, PII: 27169, DOI: 10.4161/gmic.27169, ISSN: 1949-0984.

Cover TL, Peek RM. Diet, microbial virulence, and Helicobacter pylori-induced gastric cancer. Gut Microbes [print-electronic]. 2013 Nov; 4(6): 482-93. PMID: 23989802, PMCID: PMC3928160, PII: 26262, DOI: 10.4161/gmic.26262, ISSN: 1949-0984.

Williams CS, Bradley AM, Chaturvedi R, Singh K, Piazuelo MB, Chen X, McDonough EM, Schwartz DA, Brown CT, Allaman MM, Coburn LA, Horst SN, Beaulieu DB, Choksi YA, Washington MK, Williams AD, Fisher MA, Zinkel SS, Peek RM, Wilson KT, Hiebert SW. MTG16 contributes to colonic epithelial integrity in experimental colitis. Gut [print-electronic]. 2013 Oct; 62(10): 1446-55. PMID: 22833394, PMCID: PMC3663894, PII: gutjnl-2011-301439, DOI: 10.1136/gutjnl-2011-301439, ISSN: 1468-3288.

Arboleda RN, Schneider BG, Bravo LE, Romero-Gallo J, Peek RM, Mera RM, Yepez MC, Campo C, Correa P. Use of the noninvasive entero-test in the detection of Helicobacter pylori in children in an endemic area in Colombia. J. Pediatr. Gastroenterol. Nutr. 2013 Aug; 57(2): 192-6. PMID: 23880626, PMCID: PMC3725653, PII: 00005176-201308000-00013, DOI: 10.1097/MPG.0b013e318293e1e1, ISSN: 1536-4801.

Sierra JC, Hobbs S, Chaturvedi R, Yan F, Wilson KT, Peek RM, Polk DB. Induction of COX-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2013 Jul 7/15/2013; 305(2): G196-203. PMID: 23681474, PMCID: PMC3725681, PII: ajpgi.00495.2012, DOI: 10.1152/ajpgi.00495.2012, ISSN: 1522-1547.

Wroblewski LE, Peek RM. Helicobacter pylori in gastric carcinogenesis: mechanisms. Gastroenterol. Clin. North Am [print-electronic]. 2013 Jun; 42(2): 285-98. PMID: 23639641, PMCID: PMC3648881, PII: S0889-8553(13)00024-1, DOI: 10.1016/j.gtc.2013.01.006, ISSN: 1558-1942.

Gaddy JA, Radin JN, Loh JT, Zhang F, Washington MK, Peek RM, Algood HM, Cover TL. High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis. Infect. Immun [print-electronic]. 2013 Jun; 81(6): 2258-67. PMID: 23569116, PMCID: PMC3676043, PII: IAI.01271-12, DOI: 10.1128/IAI.01271-12, ISSN: 1098-5522.

Schneider BG, Peek RM. Gastric cancer prevention by demethylation. Cancer Prev Res (Phila). 2013 Apr; 6(4): 253-6. PMID: 23559450, PMCID: PMC3620723, PII: 6/4/253, DOI: 10.1158/1940-6207.CAPR-13-0067, ISSN: 1940-6215.

Barrett CW, Ning W, Chen X, Smith JJ, Washington MK, Hill KE, Coburn LA, Peek RM, Chaturvedi R, Wilson KT, Burk RF, Williams CS. Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Cancer Res [print-electronic]. 2013 Feb 2/1/2013; 73(3): 1245-55. PMID: 23221387, PMCID: PMC3563732, PII: 0008-5472.CAN-12-3150, DOI: 10.1158/0008-5472.CAN-12-3150, ISSN: 1538-7445.

Noto JM, Khizanishvili T, Chaturvedi R, Piazuelo MB, Romero-Gallo J, Delgado AG, Khurana SS, Sierra JC, Krishna US, Suarez G, Powell AE, Goldenring JR, Coffey RJ, Yang VW, Correa P, Mills JC, Wilson KT, Peek RM. Helicobacter pylori promotes the expression of Krüppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. PLoS ONE [print-electronic]. 2013; 8(1): e54344. PMID: 23372710, PMCID: PMC3553174, PII: PONE-D-12-20127, DOI: 10.1371/journal.pone.0054344, ISSN: 1932-6203.

Noto JM, Gaddy JA, Lee JY, Piazuelo MB, Friedman DB, Colvin DC, Romero-Gallo J, Suarez G, Loh J, Slaughter JC, Tan S, Morgan DR, Wilson KT, Bravo LE, Correa P, Cover TL, Amieva MR, Peek RM. Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. J. Clin. Invest [print-electronic]. 2013 Jan; 123(1): 479-92. PMID: 23257361, PMCID: PMC3533289, PII: 64373, DOI: 10.1172/JCI64373, ISSN: 1558-8238.

Gobert AP, Verriere T, de Sablet T, Peek RM, Chaturvedi R, Wilson KT. Haem oxygenase-1 inhibits phosphorylation of the Helicobacter pylori oncoprotein CagA in gastric epithelial cells. Cell. Microbiol [print-electronic]. 2013 Jan; 15(1): 145-56. PMID: 23051580, PMCID: PMC3524338, DOI: 10.1111/cmi.12039, ISSN: 1462-5822.

Wroblewski LE, Peek RM. When guests simply will not leave. Cell Host Microbe. 2012 Dec 12/13/2012; 12(6): 733-4. PMID: 23245316, PMCID: PMC3593715, PII: S1931-3128(12)00398-8, DOI: 10.1016/j.chom.2012.11.008, ISSN: 1934-6069.

Noto JM, Peek RM. Gastric-to-intestinal transdifferentiation and cancer. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2012 Dec 12/11/2012; 109(50): 20173-4. PMID: 23184987, PMCID: PMC3528517, PII: 1218345110, DOI: 10.1073/pnas.1218345110, ISSN: 1091-6490.

Epplein M, Zheng W, Xiang YB, Peek RM, Li H, Correa P, Gao J, Michel A, Pawlita M, Cai Q, Shu XO. Prospective study of Helicobacter pylori biomarkers for gastric cancer risk among Chinese men. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2012 Dec; 21(12): 2185-92. PMID: 23035179, PMCID: PMC3518572, PII: 1055-9965.EPI-12-0792-T, DOI: 10.1158/1055-9965.EPI-12-0792-T, ISSN: 1538-7755.

Wei J, Noto J, Zaika E, Romero-Gallo J, Correa P, El-Rifai W, Peek RM, Zaika A. Pathogenic bacterium Helicobacter pylori alters the expression profile of p53 protein isoforms and p53 response to cellular stresses. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2012 Sep 9/18/2012; 109(38): E2543-50. PMID: 22927405, PMCID: PMC3458371, PII: 1205664109, DOI: 10.1073/pnas.1205664109, ISSN: 1091-6490.

Loh JT, Friedman DB, Piazuelo MB, Bravo LE, Wilson KT, Peek RM, Correa P, Cover TL. Analysis of Helicobacter pylori cagA promoter elements required for salt-induced upregulation of CagA expression. Infect. Immun [print-electronic]. 2012 Sep; 80(9): 3094-106. PMID: 22710874, PMCID: PMC3418733, PII: IAI.00232-12, DOI: 10.1128/IAI.00232-12, ISSN: 1098-5522.

Raju D, Hussey S, Ang M, Terebiznik MR, Sibony M, Galindo-Mata E, Gupta V, Blanke SR, Delgado A, Romero-Gallo J, Ramjeet MS, Mascarenhas H, Peek RM, Correa P, Streutker C, Hold G, Kunstmann E, Yoshimori T, Silverberg MS, Girardin SE, Philpott DJ, El Omar E, Jones NL. Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology [print-electronic]. 2012 May; 142(5): 1160-71. PMID: 22333951, PMCID: PMC3336037, PII: S0016-5085(12)00170-9, DOI: 10.1053/j.gastro.2012.01.043, ISSN: 1528-0012.

Sicinschi LA, Correa P, Bravo LE, Peek RM, Wilson KT, Loh JT, Yepez MC, Gold BD, Thompson DT, Cover TL, Schneider BG. Non-invasive genotyping of Helicobacter pylori cagA, vacA, and hopQ from asymptomatic children. Helicobacter. 2012 Apr; 17(2): 96-106. PMID: 22404439, PMCID: PMC3305281, DOI: 10.1111/j.1523-5378.2011.00919.x, ISSN: 1523-5378.

Sitaraman R, Israel DA, Romero-Gallo J, Peek RM. Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties. J. Clin. Microbiol [print-electronic]. 2012 Mar; 50(3): 1014-8. PMID: 22205825, PMCID: PMC3295145, PII: JCM.05252-11, DOI: 10.1128/JCM.05252-11, ISSN: 1098-660X.

Yan F, Wang L, Shi Y, Cao H, Liu L, Washington MK, Chaturvedi R, Israel DA, Cao H, Wang B, Peek RM, Wilson KT, Polk DB. Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2012 Mar 3/1/2012; 302(5): G504-14. PMID: 22173918, PMCID: PMC3311435, PII: ajpgi.00312.2011, DOI: 10.1152/ajpgi.00312.2011, ISSN: 1522-1547.

Takeuchi H, Zhang YN, Israel DA, Peek RM, Kamioka M, Yanai H, Morimoto N, Sugiura T. Effect of Helicobacter pylori cdrA on interleukin-8 secretions and nuclear factor kappa B activation. World J. Gastroenterol. 2012 Feb 2/7/2012; 18(5): 425-34. PMID: 22346248, PMCID: PMC3270507, DOI: 10.3748/wjg.v18.i5.425, ISSN: 2219-2840.

Wroblewski L, Nagy, TA, Chaturvedi R, Piazuelo MB, Romero-Gallo J, Noto JM, Wilson KT, Correa P, and Peek RM. Helicobacter pylori upregulates Snail via p38 MAPK- and TGFß-mediated signaling to promote epithelial-mesenchymal transition and disruption of apical-junctional complexes. DDW meeting, San Diego, CA. 2012.

Khizanishvili T, Noto JM, Piazuelo MB, Delgado AG, Yang VW, Correa P, and Peek RM. Helicobacter pylori promotes expression of a mediator of carcinogenesis, Kruppel-like factor 5, in vitro and in vivo. DDW meeting, San Diego, CA. 2012.

Noto JM, Gaddy JA, Lee J, Piazuelo MB, Friedman DB, Romero-Gallo J, Tan S, Wilson KT, Correa P, Correa P, Amieva MR, and Peek RM. Iron deficiency amplifies the pathogenic potential of carcinogenic cag+ Helicobacter pylori via enhancing function of the cag type IV secretion system. DDW meeting, San Diego, CA. 2012.

Suarez G, Romero-Gallo J, Piazuelo MB, Israel D, Schneider BG, Correa P, and Peek RM. Deacetylation of Helicobacter pylori peptidoglycan attenuates Nod1 activation and promotes colonization of the stomach. DDW meeting, San Diego, CA. 2012.

Sierra JC, Yan F, Romero-Gallo J, Piazuelo MB, Chaturvedi R, Wilson KT, Peek RM, and Polk DB. Epidermal growth factor receptor (EGFR) activation by Helicobacter pylori is mediated by cag-dependent and independent mechanisms. DDW meeting, San Diego, CA. 2012.

Peek RM, Kuipers EJ. Gained in translation: the importance of biologically relevant models of Helicobacter pylori-induced gastric cancer. Gut [print-electronic]. 2012 Jan; 61(1): 2-3. PMID: 21997557, PMCID: PMC3368554, PII: gutjnl-2011-301342, DOI: 10.1136/gutjnl-2011-301342, ISSN: 1468-3288.

Noto JM, Peek RM. Genetic manipulation of a naturally competent bacterium, Helicobacter pylori. Methods Mol. Biol. 2012; 921: 51-9. PMID: 23015491, PMCID: PMC3544407, DOI: 10.1007/978-1-62703-005-2_8, ISSN: 1940-6029.

Noto JM, Peek RM. The Helicobacter pylori cag Pathogenicity Island. Methods Mol. Biol. 2012; 921: 41-50. PMID: 23015490, PMCID: PMC3547679, DOI: 10.1007/978-1-62703-005-2_7, ISSN: 1940-6029.

Noto JM, Peek RM. Helicobacter pylori: an overview. Methods Mol. Biol. 2012; 921: 7-10. PMID: 23015485, DOI: 10.1007/978-1-62703-005-2_2, ISSN: 1940-6029.

Chaturvedi R, de Sablet T, Peek RM, Wilson KT. Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk. Gut Microbes. 2012 Jan; 3(1): 48-56. PMID: 22555547, PMCID: PMC3337125, PII: 19345, DOI: 10.4161/gmic.19345, ISSN: 1949-0984.

Gobert AP, Asim M, Piazuelo MB, Verriere T, Scull BP, de Sablet T, Glumac A, Lewis ND, Correa P, Peek RM, Chaturvedi R, Wilson KT. Disruption of nitric oxide signaling by Helicobacter pylori results in enhanced inflammation by inhibition of heme oxygenase-1. J. Immunol [print-electronic]. 2011 Nov 11/15/2011; 187(10): 5370-9. PMID: 21987660, PMCID: PMC3208050, PII: jimmunol.1102111, DOI: 10.4049/jimmunol.1102111, ISSN: 1550-6606.

Chaturvedi R, Asim M, Romero-Gallo J, Barry DP, Hoge S, de Sablet T, Delgado AG, Wroblewski LE, Piazuelo MB, Yan F, Israel DA, Casero RA, Correa P, Gobert AP, Polk DB, Peek RM, Wilson KT. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology [print-electronic]. 2011 Nov; 141(5): 1696-708.e1. PMID: 21839041, PMCID: PMC3202654, PII: S0016-5085(11)01080-8, DOI: 10.1053/j.gastro.2011.07.045, ISSN: 1528-0012.

de Sablet T, Piazuelo MB, Shaffer CL, Schneider BG, Asim M, Chaturvedi R, Bravo LE, Sicinschi LA, Delgado AG, Mera RM, Israel DA, Romero-Gallo J, Peek RM, Cover TL, Correa P, Wilson KT. Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut [print-electronic]. 2011 Sep; 60(9): 1189-95. PMID: 21357593, PMCID: PMC3133872, PII: gut.2010.234468, DOI: 10.1136/gut.2010.234468, ISSN: 1468-3288.

Nagy TA, Wroblewski LE, Wang D, Piazuelo MB, Delgado A, Romero-Gallo J, Noto J, Israel DA, Ogden SR, Correa P, Cover TL, Peek RM. ß-Catenin and p120 mediate PPARd-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia. Gastroenterology [print-electronic]. 2011 Aug; 141(2): 553-64. PMID: 21704622, PMCID: PMC3152603, PII: S0016-5085(11)00621-4, DOI: 10.1053/j.gastro.2011.05.004, ISSN: 1528-0012.

Hilliard VC, Frey MR, Dempsey PJ, Peek RM, Polk DB. TNF-a converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2011 Aug; 301(2): G338-46. PMID: 21617117, PMCID: PMC3154600, PII: ajpgi.00057.2011, DOI: 10.1152/ajpgi.00057.2011, ISSN: 1522-1547.

Yachimski P, Peek RM. Biomarkers in exploring the frontiers of diagnosis, prognosis, and therapy of Barrett's esophagus. Cancer Prev Res (Phila). 2011 Jun; 4(6): 783-6. PMID: 21636544, PMCID: PMC3174469, PII: 4/6/783, DOI: 10.1158/1940-6207.CAPR-11-0204, ISSN: 1940-6215.

Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, Chaturvedi R, Peek RM, Wilson KT, Polk DB. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J. Clin. Invest [print-electronic]. 2011 Jun; 121(6): 2242-53. PMID: 21606592, PMCID: PMC3104743, PII: 44031, DOI: 10.1172/JCI44031, ISSN: 1558-8238.

Soutto M, Belkhiri A, Piazuelo MB, Schneider BG, Peng D, Jiang A, Washington MK, Kokoye Y, Crowe SE, Zaika A, Correa P, Peek RM, El-Rifai W. Loss of TFF1 is associated with activation of NF-¿B-mediated inflammation and gastric neoplasia in mice and humans. J. Clin. Invest [print-electronic]. 2011 May; 121(5): 1753-67. PMID: 21490402, PMCID: PMC3083788, PII: 43922, DOI: 10.1172/JCI43922, ISSN: 1558-8238.

Epplein M, Signorello LB, Zheng W, Peek RM, Michel A, Williams SM, Pawlita M, Correa P, Cai Q, Blot WJ. Race, African ancestry, and Helicobacter pylori infection in a low-income United States population. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2011 May; 20(5): 826-34. PMID: 21357376, PMCID: PMC3089670, PII: 1055-9965.EPI-10-1258, DOI: 10.1158/1055-9965.EPI-10-1258, ISSN: 1538-7755.

Tan S, Noto JM, Romero-Gallo J, Peek RM, Amieva MR. Helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface. PLoS Pathog [print-electronic]. 2011 May; 7(5): e1002050. PMID: 21589900, PMCID: PMC3093365, PII: PPATHOGENS-D-10-00302, DOI: 10.1371/journal.ppat.1002050, ISSN: 1553-7374.

Nagy TA, Allen SS, Wroblewski LE, Flaherty DK, Slaughter JC, Perez-Perez G, Israel DA, Peek RM. Helicobacter pylori induction of eosinophil migration is mediated by the cag pathogenicity island via microbial-epithelial interactions. Am. J. Pathol [print-electronic]. 2011 Apr; 178(4): 1448-52. PMID: 21406172, PMCID: PMC3078468, PII: S0002-9440(10)00281-6, DOI: 10.1016/j.ajpath.2010.12.018, ISSN: 1525-2191.

Noto J, Piazuelo MB, Romero-Gallo J, Delgado A, Tan S, Lee J, Correa P, Amieva M, and Peek RM. Iron deficiency amplifies Helicobacter pylori virulence and accelerates gastric carcinogenesis. DDW meeting, Chicago, IL. 2011.

Wroblewski L, Noto J, Romero-Gallo J, Delgado A, Piazuelo MB, Suarez G, Israel DA, Correa P, Philpott DJ, and Peek RM. Up-regulation of the Helicobacter pylori receptor Decay-Accelerating Factor is mediated by peptidoglycan-dependent activation of Nod1. DDW meeting, Chicago, IL. 2011.

Zhang YM, Hammond CE, Peek RM, Backert S, and Smolka AJ. H. pylori-induced down-regulation of H,K-ATPase expression is independent of CagA translocation and induction of IL-8. DDW meeting, Chicago, IL. 2011.

Wroblewski LE, Noto JM, Romero-Gallo J, Delgado A, Piazuelo MB, Suarez G, Israel DA, Correa P, Philpott DJ, and Peek RM. Snail mediates peptidoglycan-dependent up-regulation of the Helicobacter pylori receptor Decay-Accelerating Factor. 16th International Workshop on Campylobacter, Helicobacter and related organisms, Vancouver, CA. 2011.

Israel DA, Ghandhi N, and Peek RM. Helicobacter pylori pgdA sequence variation segregates with bacterial phylogeographic origin. 16th International Workshop on Campylobacter, Helicobacter and related organisms, Vancouver, CA. 2011.

Noto J, Lee J, Piazuelo MB, Romero-Gallo J, Ghandhi N, Tan S, Lee J, Correa P, Amieva M, and Peek RM. Iron deficiency accelerates Helicobacter pylori-induced gastric carcinogenesis. 16th International Workshop on Campylobacter, Helicobacter and related organisms, Vancouver, CA. 2011.

Wroblewski LE, Peek RM. "Targeted disruption of the epithelial-barrier by Helicobacter pylori". Cell Commun. Signal. 2011; 9(1): 29. PMID: 22044698, PMCID: PMC3225297, PII: 1478-811X-9-29, DOI: 10.1186/1478-811X-9-29, ISSN: 1478-811X.

Noto JM, Peek RM. The role of microRNAs in Helicobacter pylori pathogenesis and gastric carcinogenesis. Front Cell Infect Microbiol. 2011; 1: 21. PMID: 22919587, PMCID: PMC3417373, DOI: 10.3389/fcimb.2011.00021, ISSN: 2235-2988.

Schneider BG, Peng DF, Camargo MC, Piazuelo MB, Sicinschi LA, Mera R, Romero-Gallo J, Delgado AG, Bravo LE, Wilson KT, Peek RM, Correa P, El-Rifai W. Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer. Int. J. Cancer. 2010 Dec 12/1/2010; 127(11): 2588-97. PMID: 20178103, PMCID: PMC2916942, DOI: 10.1002/ijc.25274, ISSN: 1097-0215.

Nam KT, Lee HJ, Sousa JF, Weis VG, O'Neal RL, Finke PE, Romero-Gallo J, Shi G, Mills JC, Peek RM, Konieczny SF, Goldenring JR. Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology [print-electronic]. 2010 Dec; 139(6): 2028-2037.e9. PMID: 20854822, PMCID: PMC2997152, PII: S0016-5085(10)01321-1, DOI: 10.1053/j.gastro.2010.09.005, ISSN: 1528-0012.

Tsang YH, Lamb A, Romero-Gallo J, Huang B, Ito K, Peek RM, Ito Y, Chen LF. Helicobacter pylori CagA targets gastric tumor suppressor RUNX3 for proteasome-mediated degradation. Oncogene [print-electronic]. 2010 Oct 10/14/2010; 29(41): 5643-50. PMID: 20676134, PMCID: PMC2980823, PII: onc2010304, DOI: 10.1038/onc.2010.304, ISSN: 1476-5594.

Wroblewski LE, Peek RM, Wilson KT. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin. Microbiol. Rev. 2010 Oct; 23(4): 713-39. PMID: 20930071, PMCID: PMC2952980, PII: 23/4/713, DOI: 10.1128/CMR.00011-10, ISSN: 1098-6618.

Wei J, Nagy TA, Vilgelm A, Zaika E, Ogden SR, Romero-Gallo J, Piazuelo MB, Correa P, Washington MK, El-Rifai W, Peek RM, Zaika A. Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells. Gastroenterology [print-electronic]. 2010 Oct; 139(4): 1333-43. PMID: 20547161, PMCID: PMC2949494, PII: S0016-5085(10)00877-2, DOI: 10.1053/j.gastro.2010.06.018, ISSN: 1528-0012.

Peek RM, Fiske C, Wilson KT. Role of innate immunity in Helicobacter pylori-induced gastric malignancy. Physiol. Rev. 2010 Jul; 90(3): 831-58. PMID: 20664074, PMCID: PMC2990353, PII: 90/3/831, DOI: 10.1152/physrev.00039.2009, ISSN: 1522-1210.

Saha A, Hammond CE, Beeson C, Peek RM, Smolka AJ. Helicobacter pylori represses proton pump expression and inhibits acid secretion in human gastric mucosa. Gut. 2010 Jul; 59(7): 874-81. PMID: 20581234, PMCID: PMC2980826, PII: 59/7/874, DOI: 10.1136/gut.2009.194795, ISSN: 1468-3288.

Miles S, Piazuelo MB, Semino-Mora C, Washington MK, Dubois A, Peek RM, Correa P, Merrell DS. Detailed in vivo analysis of the role of Helicobacter pylori Fur in colonization and disease. Infect. Immun [print-electronic]. 2010 Jul; 78(7): 3073-82. PMID: 20421381, PMCID: PMC2897407, PII: IAI.00190-10, DOI: 10.1128/IAI.00190-10, ISSN: 1098-5522.

Sicinschi LA, Correa P, Peek RM, Camargo MC, Piazuelo MB, Romero-Gallo J, Hobbs SS, Krishna U, Delgado A, Mera R, Bravo LE, Schneider BG. CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions. Clin. Microbiol. Infect [print-electronic]. 2010 Apr; 16(4): 369-78. PMID: 19456839, PMCID: PMC2837774, PII: S1198-743X(14)63302-4, DOI: 10.1111/j.1469-0691.2009.02811.x, ISSN: 1469-0691.

Styer CM, Hansen LM, Cooke CL, Gundersen AM, Choi SS, Berg DE, Benghezal M, Marshall BJ, Peek RM, Borén T, Solnick JV. Expression of the BabA adhesin during experimental infection with Helicobacter pylori. Infect. Immun [print-electronic]. 2010 Apr; 78(4): 1593-600. PMID: 20123715, PMCID: PMC2849406, PII: IAI.01297-09, DOI: 10.1128/IAI.01297-09, ISSN: 1098-5522.

Noto J, Bartel C, Thatcher E, Patton J, and Peek RM. Strain-specific downregulation of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the cell survival protein, Mcl-1. DDW meeting, New Orleans, LA. 2010.

Nagy T, Wang D, Wroblewski LE, Ogden S, Allen S, Israel D, and Peek RM. Selective activation of PPAR delta by Helicobacter pylori cag island substrates regulates epithelial cell proliferation. DDW meeting, New Orleans, LA. 2010.

Wroblewski LE, Nagy T, Chaturvedi R, Piazuelo MB, Romero-Gallo J, Wilson KT, Correa P, and Peek RM. Dysregulation of claudin-7 and β-catenin by Helicobacter pylori in vitro and within inflamed gastric mucosa. DDW meeting, New Orleans, LA. 2010.

Soutto M, Schneider B, Piazuelo MB, Washington MK, Crowe S, Correa P, Peek RM, and El-Rifai W. Molecular signature of NF-kB signaling in the TFF1-knockout mouse model of gastric neoplasia. DDW meeting, New Orleans, LA. 2010.

Bott CJ, Hammond CE, Lewin D, Romero-Gallo J, Peek RM, and Smolka AJ. Acute H. pylori infection of gerbils down-regulates in vivo H,K-ATPase expression and is cagL-dependent. DDW meeting, New Orleans, LA. 2010.

de Sablet T, Piazuelo MB, Shaffer CL, Schneider BG, Asim M, Chaturvedi R, Sicinschi LA, Israel D, Romero-Gallo J, Peek RM, Cover TL, Correa P, and Wilson KT. European phylogenetic origin of Helicobacter pylori strains as a risk factor for premalignant gastric lesions in Colombia. DDW meeting, New Orleans, LA. 2010.

Ogden SR, Noto JM, Allen SS, Patel DA, Romero-Gallo J, Washington MK, Fingleton B, Israel DA, Lewis ND, Wilson KT, Chaturvedi R, Zhao Z, Shyr Y, Peek RM. Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice. Cancer Res. 2010 Jan 1/1/2010; 70(1): 30-5. PMID: 20048070, PMCID: PMC2804939, PII: 0008-5472.CAN-09-2899, DOI: 10.1158/0008-5472.CAN-09-2899, ISSN: 1538-7445.

Algood HM, Allen SS, Washington MK, Peek RM, Miller GG, Cover TL. Regulation of gastric B cell recruitment is dependent on IL-17 receptor A signaling in a model of chronic bacterial infection. J. Immunol [print-electronic]. 2009 Nov 11/1/2009; 183(9): 5837-46. PMID: 19812196, PMCID: PMC2834183, PII: jimmunol.0901206, DOI: 10.4049/jimmunol.0901206, ISSN: 1550-6606.

Lamb A, Yang XD, Tsang YH, Li JD, Higashi H, Hatakeyama M, Peek RM, Blanke SR, Chen LF. Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination. EMBO Rep [print-electronic]. 2009 Nov; 10(11): 1242-9. PMID: 19820695, PMCID: PMC2775174, PII: embor2009210, DOI: 10.1038/embor.2009.210, ISSN: 1469-3178.

Franco AT, Friedman DB, Nagy TA, Romero-Gallo J, Krishna U, Kendall A, Israel DA, Tegtmeyer N, Washington MK, Peek RM. Delineation of a carcinogenic Helicobacter pylori proteome. Mol. Cell Proteomics [print-electronic]. 2009 Aug; 8(8): 1947-58. PMID: 19470446, PMCID: PMC2722763, PII: M900139-MCP200, DOI: 10.1074/mcp.M900139-MCP200, ISSN: 1535-9484.

Yang L, Lu X, Nossa CW, Francois F, Peek RM, Pei Z. Inflammation and intestinal metaplasia of the distal esophagus are associated with alterations in the microbiome. Gastroenterology [print-electronic]. 2009 Aug; 137(2): 588-97. PMID: 19394334, PMCID: PMC2963147, PII: S0016-5085(09)00559-9, DOI: 10.1053/j.gastro.2009.04.046, ISSN: 1528-0012.

Schneider N, Krishna U, Romero-Gallo J, Israel DA, Piazuelo MB, Camargo MC, Sicinschi LA, Schneider BG, Correa P, Peek RM. Role of Helicobacter pylori CagA molecular variations in induction of host phenotypes with carcinogenic potential. J. Infect. Dis. 2009 Apr 4/15/2009; 199(8): 1218-21. PMID: 19278338, PMCID: PMC2828761, DOI: 10.1086/597416, ISSN: 0022-1899.

Nam KT, Lee HJ, Mok H, Romero-Gallo J, Crowe JE, Peek RM, Goldenring JR. Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. Gastroenterology [print-electronic]. 2009 Apr; 136(4): 1288-96. PMID: 19230855, PMCID: PMC2844775, PII: S0016-5085(08)02261-0, DOI: 10.1053/j.gastro.2008.12.037, ISSN: 1528-0012.

Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs SS, Dempsey PJ, Peek RM, Cover TL, Washington MK, Wilson KT, Polk DB. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology [print-electronic]. 2009 Apr; 136(4): 1297-1307, e1. PMID: 19250983, PMCID: PMC2878739, PII: S0016-5085(08)02317-2, DOI: 10.1053/j.gastro.2008.12.059, ISSN: 1528-0012.

Nagy TA, Frey MR, Yan F, Israel DA, Polk DB, Peek RM. Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J. Infect. Dis. 2009 Mar 3/1/2009; 199(5): 641-51. PMID: 19199544, PMCID: PMC2830010, PII: 10.1086/596660, DOI: 10.1086/596660, ISSN: 0022-1899.

Bronte-Tinkew DM, Terebiznik M, Franco A, Ang M, Ahn D, Mimuro H, Sasakawa C, Ropeleski MJ, Peek RM, Jones NL. Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo. Cancer Res. 2009 Jan 1/15/2009; 69(2): 632-9. PMID: 19147578, PMCID: PMC3418672, PII: 69/2/632, DOI: 10.1158/0008-5472.CAN-08-1191, ISSN: 1538-7445.

Nagy T, Franco A, Friedman D, Krishna US, Kendall A, Israel D, Backert S, and Peek RM. Delineation of a pathogenic Helicobacter pylori proteome identifies a locus that modifies cag secretion system substrates. DDW meeting, Chicago, IL. 2009.

Wroblewski LE, Ogden SR, Nagy T, Allen SS, Romero-Gallo J, Israel D, and Peek RM. Helicobacter pylori reciprocally alter expression of JAM-A and claudin-7 in gastric epithelial cells. DDW meeting, Chicago, IL. 2009.

Sablet T, Chaturvedi R, Romero-Gallo J, Piazuelo MB, Washington MK, Delgado AG, Asim M, Schneider BG, Sicinschi LA, Israel D, Peek RM, Correa P, and Wilson KT. Increased gastric dysplasia and carcinoma in gerbils infected with Helicobacter pylori strains from regions of high versus low risk for gastric cancer in Colombia. DDW meeting, Chicago, IL. 2009.

Sicinschi LA, Correa P, Peek RM, Loh JT, Piazuelo MB, Delgado AG, Shaffer CM, Gold BD, Thompson DT, Bravo LE, and Schneider BG. Virulence genotyping of Helicobacter pylori using stool DNA samples from Colombian children. DDW meeting, Chicago, IL. 2009.

Hobbs S, Ogden SR, Peek RM, Whitehead RH, Dempsey PJ, and Polk DB. Helicobacter pylori transactivation of EGFR induces COX-2 expression in gastric epithelial cells. DDW meeting, Chicago, IL. 2009.

Keates AC, Peek RM, Robson SC, and Keates SE. Helicobacter pylori–induced shedding of c-MET by AGS gastric epithelial cells is mediated by ADAM-17. DDW meeting, Chicago, IL. 2009.

Chaturvedi R, Yan F, Peek RM, Polk DB, and Wilson KT. Epidermal growth factor receptor activation by Helicobacter pylori results in a population of gastric epithelial cells with oxidative DNA damage that are resistant to apoptosis: implications for gastric carcinogenesis. DDW meeting, Chicago, IL. 2009.

Piazuelo MB, Camargo MC, Delgado AG, Romero-Gallo J, Sicinschi LA, Schneider BG, Peek RM, Bravo LE, and Correa P. Free radical scavenger enzymes in gastric mucosa of two Colombian populations with contrasting risks of gastric cancer. DDW meeting, Chicago, IL. 2009.

Nagy T, Wroblewski L, Ogden S, Allen SS, and Peek RM. Helicobacter pylori induces hyperproliferation in a three-dimensional culture system in conjunction with up-regulation of ß-catenin target genes. 15th International Workshop on Campylobacter, Helicobacter and related organisms, Niigata, Japan. 2009.

Wroblewski L, Ogden S, Nagy TA, Allen SS, Romero-Gallo J, Israel DA, and Peek RM. Dysregulation of claudin-7 by Helicobacter pylori affects tight junction function in gastric epithelial cells. 15th International Workshop on Campylobacter, Helicobacter and related organisms, Niigata, Japan. 2009.

Wroblewski LE, Shen L, Ogden S, Romero-Gallo J, Lapierre LA, Israel DA, Turner JR, Peek RM. Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation. Gastroenterology [print-electronic]. 2009 Jan; 136(1): 236-46. PMID: 18996125, PMCID: PMC2678540, PII: S0016-5085(08)01804-0, DOI: 10.1053/j.gastro.2008.10.011, ISSN: 1528-0012.

McClain MS, Shaffer CL, Israel DA, Peek RM, Cover TL. Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer. BMC Genomics. 2009; 10: 3. PMID: 19123947, PMCID: PMC2627912, PII: 1471-2164-10-3, DOI: 10.1186/1471-2164-10-3, ISSN: 1471-2164.

Shimada M, Ando T, Peek RM, Watanabe O, Ishiguro K, Maeda O, Ishikawa D, Hasegawa M, Ina K, Ohmiya N, Niwa Y, Goto H. Helicobacter pylori infection upregulates interleukin-18 production from gastric epithelial cells. Eur J Gastroenterol Hepatol. 2008 Dec; 20(12): 1144-50. PMID: 18946358, PMCID: PMC3372857, DOI: 10.1097/MEG.0b013e32830edb15, ISSN: 1473-5687.

Ogden SR, Wroblewski LE, Weydig C, Romero-Gallo J, O'Brien DP, Israel DA, Krishna US, Fingleton B, Reynolds AB, Wessler S, Peek RM. P120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7. Mol. Biol. Cell [print-electronic]. 2008 Oct; 19(10): 4110-21. PMID: 18653469, PMCID: PMC2555941, PII: E08-03-0283, DOI: 10.1091/mbc.E08-03-0283, ISSN: 1939-4586.

Piazuelo MB, Camargo MC, Mera RM, Delgado AG, Peek RM, Correa H, Schneider BG, Sicinschi LA, Mora Y, Bravo LE, Correa P. Eosinophils and mast cells in chronic gastritis: possible implications in carcinogenesis. Hum. Pathol [print-electronic]. 2008 Sep; 39(9): 1360-9. PMID: 18614201, PMCID: PMC2561958, PII: S0046-8177(08)00058-0, DOI: 10.1016/j.humpath.2008.01.012, ISSN: 1532-8392.

Keates AC, Tummala S, Peek RM, Csizmadia E, Kunzli B, Becker K, Correa P, Romero-Gallo J, Piazuelo MB, Sheth S, Kelly CP, Robson SC, Keates S. Helicobacter pylori infection stimulates plasminogen activator inhibitor 1 production by gastric epithelial cells. Infect. Immun [print-electronic]. 2008 Sep; 76(9): 3992-9. PMID: 18519558, PMCID: PMC2519438, PII: IAI.00584-08, DOI: 10.1128/IAI.00584-08, ISSN: 1098-5522.

O'Brien DP, Romero-Gallo J, Schneider BG, Chaturvedi R, Delgado A, Harris EJ, Krishna U, Ogden SR, Israel DA, Wilson KT, Peek RM. Regulation of the Helicobacter pylori cellular receptor decay-accelerating factor. J. Biol. Chem [print-electronic]. 2008 Aug 8/29/2008; 283(35): 23922-30. PMID: 18579524, PMCID: PMC2527108, PII: M801144200, DOI: 10.1074/jbc.M801144200, ISSN: 0021-9258.

Goodwin AC, Weinberger DM, Ford CB, Nelson JC, Snider JD, Hall JD, Paules CI, Peek RM, Forsyth MH. Expression of the Helicobacter pylori adhesin SabA is controlled via phase variation and the ArsRS signal transduction system. Microbiology (Reading, Engl.). 2008 Aug; 154(Pt 8): 2231-40. PMID: 18667556, PMCID: PMC2715451, PII: 154/8/2231, DOI: 10.1099/mic.0.2007/016055-0, ISSN: 1350-0872.

Ding SZ, Olekhnovich IN, Cover TL, Peek RM, Smith MF, Goldberg JB. Helicobacter pylori and mitogen-activated protein kinases mediate activator protein-1 (AP-1) subcomponent protein expression and DNA-binding activity in gastric epithelial cells. FEMS Immunol. Med. Microbiol [print-electronic]. 2008 Aug; 53(3): 385-94. PMID: 18625013, PMCID: PMC2553690, PII: FIM439, DOI: 10.1111/j.1574-695X.2008.00439.x, ISSN: 0928-8244.

Peek RM. Helicobacter pylori infection and disease: from humans to animal models. Dis Model Mech. 2008 Jul; 1(1): 50-5. PMID: 19048053, PMCID: PMC2561984, DOI: 10.1242/dmm.000364, ISSN: 1754-8411.

Peek RM. Prevention of Gastric Cancer: When is Treatment of Helicobacter Pylori Warranted?. Therap Adv Gastroenterol. 2008 Jul; 1(1): 19-31. PMID: 20953278, PMCID: PMC2954602, DOI: 10.1177/1756283X08093567, ISSN: 1756-283X.

Wei J, O'Brien D, Vilgelm A, Piazuelo MB, Correa P, Washington MK, El-Rifai W, Peek RM, Zaika A. Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family. Gastroenterology [print-electronic]. 2008 May; 134(5): 1412-23. PMID: 18343378, PMCID: PMC2430883, PII: S0016-5085(08)00178-9, DOI: 10.1053/j.gastro.2008.01.072, ISSN: 1528-0012.

Sicinschi LA, Correa P, Peek RM, Camargo MC, Delgado A, Piazuelo MB, Romero-Gallo J, Bravo LE, Schneider BG. Helicobacter pylori genotyping and sequencing using paraffin-embedded biopsies from residents of colombian areas with contrasting gastric cancer risks. Helicobacter. 2008 Apr; 13(2): 135-45. PMID: 18321303, PMCID: PMC2977907, PII: HEL554, DOI: 10.1111/j.1523-5378.2008.00554.x, ISSN: 1523-5378.

Romero-Gallo J, Harris EJ, Krishna U, Washington MK, Perez-Perez GI, Peek RM. Effect of Helicobacter pylori eradication on gastric carcinogenesis. Lab. Invest [print-electronic]. 2008 Mar; 88(3): 328-36. PMID: 18180700, PMCID: PMC2833422, PII: 3700719, DOI: 10.1038/labinvest.3700719, ISSN: 1530-0307.

Franco AT, Johnston E, Krishna U, Yamaoka Y, Israel DA, Nagy TA, Wroblewski LE, Piazuelo MB, Correa P, Peek RM. Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors. Cancer Res. 2008 Jan 1/15/2008; 68(2): 379-87. PMID: 18199531, PMCID: PMC3114460, PII: 68/2/379, DOI: 10.1158/0008-5472.CAN-07-0824, ISSN: 1538-7445.

Nagy T, Frey M, Yan F, Israel D, Polk DB, and Peek RM. H. pylori–mediated translocation of peptidoglycan is required for microbially-induced epithelial responses that heighten the risk for carcinogenesis. DDW meeting, San Diego, CA. 2008.

Wroblewski L, Shen L, Nagy T, Ogden S, Allen SS, Turner J, and Peek RM. Helicobacter pylori alters gastric epithelial tight junctions in a myosin light chain kinase-dependent manner. DDW meeting, San Diego, CA. 2008.

Schneider N, Krishna U, Romero-Gallo J, Piazuelo MB, Camargo MC, Sicinschi LA, Schneider BG, Correa P, and Peek RM. The role of CagA molecular variations in induction of host phenotypes with carcinogenic potential. DDW meeting, San Diego, CA. 2008.

Allen S, Wroblewski L, Piazuelo MB, Delgado A, Correa P, and Peek RM. Helicobacter pylori cag+ strains selectively induce epithelial secretion of eosinophil chemoattractants. DDW meeting, San Diego, CA. 2008.

Algood HM, Gallo-Romero J, Wilson KT, Peek RM, Cover TL. Host response to Helicobacter pylori infection before initiation of the adaptive immune response. FEMS Immunol. Med. Microbiol [print-electronic]. 2007 Dec; 51(3): 577-86. PMID: 17919297, PII: FIM338, DOI: 10.1111/j.1574-695X.2007.00338.x, ISSN: 0928-8244.

Wroblewski LE, Peek RM. Orchestration of dysregulated epithelial turnover by a manipulative pathogen. Cell Host Microbe. 2007 Oct 10/11/2007; 2(4): 209-11. PMID: 18005737, PII: S1931-3128(07)00227-2, DOI: 10.1016/j.chom.2007.09.011, ISSN: 1934-6069.

Murata-Kamiya N, Kurashima Y, Teishikata Y, Yamahashi Y, Saito Y, Higashi H, Aburatani H, Akiyama T, Peek RM, Azuma T, Hatakeyama M. Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene [print-electronic]. 2007 Jul 7/12/2007; 26(32): 4617-26. PMID: 17237808, PII: 1210251, DOI: 10.1038/sj.onc.1210251, ISSN: 0950-9232.

Keates S, Keates AC, Katchar K, Peek RM, Kelly CP. Helicobacter pylori induces up-regulation of the epidermal growth factor receptor in AGS gastric epithelial cells. J. Infect. Dis [print-electronic]. 2007 Jul 7/1/2007; 196(1): 95-103. PMID: 17538889, PII: JID37724, DOI: 10.1086/518440, ISSN: 0022-1899.

Steele IA, Dimaline R, Pritchard DM, Peek RM, Wang TC, Dockray GJ, Varro A. Helicobacter and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2007 Jul; 293(1): G347-54. PMID: 17463184, PII: 00076.2007, DOI: 10.1152/ajpgi.00076.2007, ISSN: 0193-1857.

Corcoran PA, Atherton JC, Kerrigan SW, Wadstrom T, Murray FE, Peek RM, Fitzgerald DJ, Cox DM, Byrne MF. The effect of different strains of Helicobacter pylori on platelet aggregation. Can. J. Gastroenterol. 2007 Jun; 21(6): 367-70. PMID: 17571170, PMCID: PMC2658119, ISSN: 0835-7900.

Ghose C, Perez-Perez GI, Torres VJ, Crosatti M, Nomura A, Peek RM, Cover TL, Francois F, Blaser MJ. Serological assays for identification of human gastric colonization by Helicobacter pylori strains expressing VacA m1 or m2. Clin. Vaccine Immunol [print-electronic]. 2007 Apr; 14(4): 442-50. PMID: 17267587, PMCID: PMC1865612, PII: CVI.00434-06, DOI: 10.1128/CVI.00434-06, ISSN: 1556-6811.

Franco A and Peek RM. Helicobacter pylori CagA regulates gastric carcinogenesis. Inflammation and Cancer. Keystone Symposia, Santa Fe, NM. 2007.

Franco A, Johnston E, Romero-Gallo J, and Peek RM. Helicobacter pylori-induced gastric cancer is dependent on CagA. DDW meeting, Washington, D.C. 2007.

O’Brien D, Romero-Gallo J, Johnston E, Krishna U, Israel D, Ogden S, and Peek RM. Regulation of the H. pylori cellular receptor decay-accelerating factor (DAF). DDW meeting, Washington, D.C. 2007.

Nagy T, Frey M, Franco A, Ogden S, O’Brien D, Wroblewski L, Krishna U, Romero-Gallo J, Hobbs S, Israel D, Polk DB, and Peek RM. Activation of AKT by Helicobacter pylori is dependent on the cag pathogenicity island. DDW meeting, Washington, D.C. 2007.

Ogden S, O’Brien D, Romero-Gallo J, Krishna U, Israel D, Reynolds A, and Peek RM. Helicobacter pylori alters the subcellular localization of p120-catenin in gastric epithelial cells. DDW meeting, Washington, D.C. 2007.

Wroblewski L, Romero-Gallo J, Shen L, Turner J, Israel D, Franco A, Krishna U, and Peek RM. Helicobacter pylori induces mislocalization of occludin in gastric epithelial cells. DDW meeting, Washington, D.C. 2007.

Bronte-Tinkew D, Terebiznik M, Ahn D, Mimuro, Sasakawa C, Peek RM, and Jones NL. Helicobacter pylori effector protein CagA activates the signal transduction and activator of transcription 3 (STAT3) signaling pathway: a potential mechanism for gastric cancer development. DDW meeting, Washington, D.C. 2007.

Steele I, Dimaline R, Dockray G, Peek RM, Pritchard MD, Wang TC, and Varro A. Regulation of the putative growth factor Reg-I in the gastric epithelium by gastrin and Helicobacter pylori via distinct promoter elements. DDW meeting, Washington, D.C. 2007.

Wei J, O’Brien D, Vilgelm A, Piazuelo MB, Washington MK. El-Rifai W, Peek RM, and Zaika A.. Interactions of p73 and p63 proteins play important role in H. pylori infection. DDW meeting, Washington, D.C. 2007.

Hobbs S, Krishna U, Peek RM, Whitehead RH, and Polk DB. Transactivation of EGFR by TNF modulates TNF-stimulated COX-2 expression. DDW meeting, Washington, D.C. 2007.

Sicinschi LA, Correa P, Peek RM, Camargo MC, Delgado A, Piazuelo MB, Bravo LE, Schneider BG. Helicobacter pylori genotyping from paraffin-embedded gastric biopsies in contrasting gastric cancer risk Colombian areas. DDW meeting, Washington, D.C. 2007.

Camargo MC, Mera R, Correa P, Peek RM, Fontham ET, Goodman KJ, Piazuelo MB, Sicinschi L, Zabaleta J, Schneider BG. Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis. Cancer Epidemiol. Biomarkers Prev. 2006 Sep; 15(9): 1674-87. PMID: 16985030, PII: 15/9/1674, DOI: 10.1158/1055-9965.EPI-06-0189, ISSN: 1055-9965.

Peek RM, Schneider BG, Correa P. Coming unglued. Clin. Cancer Res. 2006 May 5/15/2006; 12(10): 2951-4. PMID: 16707587, PII: 12/10/2951, DOI: 10.1158/1078-0432.CCR-06-0460, ISSN: 1078-0432.

O'Brien DP, Israel DA, Krishna U, Romero-Gallo J, Nedrud J, Medof ME, Lin F, Redline R, Lublin DM, Nowicki BJ, Franco AT, Ogden S, Williams AD, Polk DB, Peek RM. The role of decay-accelerating factor as a receptor for Helicobacter pylori and a mediator of gastric inflammation. J. Biol. Chem [print-electronic]. 2006 May 5/12/2006; 281(19): 13317-23. PMID: 16543227, PII: M601805200, DOI: 10.1074/jbc.M601805200, ISSN: 0021-9258.

Williams RE, Sitaraman R, Krishna US, Israel DA, O’Brien DP, Ogden SR, Franco AT, Romero-Gallo J, Yan F, Polk DP, and Peek RM. Regulation of pathogenic responses in gastric epithelial cells by Helicobacter pylori sphingomyelinase. DDW meeting, Los Angeles, CA. 2006.

Ogden SR, Franco AT, Krishna US, Israel DA, Fingleton B, Matrisian LM, Crawford HC, and Peek RM. Helicobacter pylori induction of matrix metalloproteinase-7. DDW meeting, Los Angeles, CA. 2006.

O’Brien D, Krishna U, Romero-Gallo J, Nedrud J, Medof E, Lin F, Redline R, Lublin D, Nowicki BJ, Israel D, Franco A, and Peek RM. Decay-accelerating factor (DAF) is a cellular receptor for Helicobacter pylori. DDW meeting, Los Angeles, CA. 2006.

Chaturvedi R, Asim M, Bussiere FI, Singh K, Casero RA, Peek RM, and Wilson KT. Spermine oxidase as the link between H. pylori cagA and gastric carcinogenesis. DDW meeting, Los Angeles, CA. 2006.

Algood HMS, Romero-Gallo J, Peek RM, and Cover TL. Acute immune responses to Helicobacter pylori in the mouse model. ASM meeting, Orlando, FL. 2006.

Peek RM, Crabtree JE. Helicobacter infection and gastric neoplasia. J. Pathol. 2006 Jan; 208(2): 233-48. PMID: 16362989, DOI: 10.1002/path.1868, ISSN: 0022-3417.

Israel DA, Peek RM. The role of persistence in Helicobacter pylori pathogenesis. Curr. Opin. Gastroenterol. 2006 Jan; 22(1): 3-7. PMID: 16319669, PII: 00001574-200601000-00003, ISSN: 0267-1379.

Pei Z, Yang L, Peek RM, Jr Levine SM, Pride DT, Blaser MJ. Bacterial biota in reflux esophagitis and Barrett's esophagus. World J. Gastroenterol. 2005 Dec 12/14/2005; 11(46): 7277-83. PMID: 16437628, PMCID: PMC3025696, ISSN: 1007-9327.

Bhat N, Gaensbauer J, Peek RM, Bloch K, Tham KT, Blaser MJ, Perez-Perez G. Local and systemic immune and inflammatory responses to Helicobacter pylori strains. Clin. Diagn. Lab. Immunol. 2005 Dec; 12(12): 1393-400. PMID: 16339062, PMCID: PMC1317075, PII: 12/12/1393, DOI: 10.1128/CDLI.12.12.1393-1400.2005, ISSN: 1071-412X.

Mizuno T, Ando T, Nobata K, Tsuzuki T, Maeda O, Watanabe O, Minami M, Ina K, Kusugami K, Peek RM, Goto H. Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization. World J. Gastroenterol. 2005 Oct 10/28/2005; 11(40): 6305-11. PMID: 16419159, PMCID: PMC4320334, ISSN: 1007-9327.

Peek RM, Mohla S, DuBois RN. Inflammation in the genesis and perpetuation of cancer: summary and recommendations from a national cancer institute-sponsored meeting. Cancer Res. 2005 Oct 10/1/2005; 65(19): 8583-6. PMID: 16204020, PII: 65/19/8583, DOI: 10.1158/0008-5472.CAN-05-1777, ISSN: 0008-5472.

Peek RM. Pathogenesis of Helicobacter pylori infection. Springer Semin. Immunopathol [print-electronic]. 2005 Sep; 27(2): 197-215. PMID: 15928915, DOI: 10.1007/s00281-005-0204-8, ISSN: 0344-4325.

Franco AT, Israel DA, Washington MK, Krishna U, Fox JG, Rogers AB, Neish AS, Collier-Hyams L, Perez-Perez GI, Hatakeyama M, Whitehead R, Gaus K, O'Brien DP, Romero-Gallo J, Peek RM. Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2005 Jul 7/26/2005; 102(30): 10646-51. PMID: 16027366, PMCID: PMC1180811, PII: 0504927102, DOI: 10.1073/pnas.0504927102, ISSN: 0027-8424.

Peek RM. Events at the host-microbial interface of the gastrointestinal tract IV. The pathogenesis of Helicobacter pylori persistence. Am. J. Physiol. Gastrointest. Liver Physiol. 2005 Jul; 289(1): G8-12. PMID: 15961885, PII: 289/1/G8, DOI: 10.1152/ajpgi.00086.2005, ISSN: 0193-1857.

Terry CE, McGinnis LM, Madigan KC, Cao P, Cover TL, Liechti GW, Peek RM, Forsyth MH. Genomic Comparison of cag pathogenicity island (PAI)-positive and -negative Helicobacter pylori strains: identification of novel markers for cag PAI-positive strains. Infect. Immun. 2005 Jun; 73(6): 3794-8. PMID: 15908415, PMCID: PMC1111835, PII: 73/6/3794, DOI: 10.1128/IAI.73.6.3794-3798.2005, ISSN: 0019-9567.

Popescu A, Karpay A, Israel DA, Peek RM, Krezel AM. Helicobacter pylori protein HP0222 belongs to Arc/MetJ family of transcriptional regulators. Proteins. 2005 May 5/1/2005; 59(2): 303-11. PMID: 15723352, DOI: 10.1002/prot.20406, ISSN: 1097-0134.

Nomura S, Settle SH, Leys CM, Means AL, Peek RM, Leach SD, Wright CV, Coffey RJ, Goldenring JR. Evidence for repatterning of the gastric fundic epithelium associated with Ménétrier's disease and TGFalpha overexpression. Gastroenterology. 2005 May; 128(5): 1292-305. PMID: 15887112, PII: S0016508505004038, ISSN: 0016-5085.

Backert S, Kwok T, Schmid M, Selbach M, Moese S, Peek RM, König W, Meyer TF, Jungblut PR. Subproteomes of soluble and structure-bound Helicobacter pylori proteins analyzed by two-dimensional gel electrophoresis and mass spectrometry. Proteomics. 2005 Apr; 5(5): 1331-45. PMID: 15717330, DOI: 10.1002/pmic.200401019, ISSN: 1615-9853.

Franco AT, Israel DA, Washington MK, Fox JG, Rogers AB, Neish AS, Collier-Hyams L, Perez-Perez GI, Hatakeyama M, Whitehead R, Krishna US, Gaus K, O’Brien DP, and Peek RM. In vivo adaptation endows Helicobacter pylori with the ability to rapidly induce gastric cancer and activate ß-catenin. DDW meeting, Chicago, IL. 2005.

Yan F, Krishna US, Peek RM, Kamel M, and Polk DB. EGF Receptor (EGFR) activation plays an anti-apoptotic role in CagA-dependent Helicobacter pylori-induced gastric epithelial cell apoptosis. DDW meeting, Chicago, IL. 2005.

Yan F, Krishna US, Peek RM, Kamel M, Frey M, Riggins K, Dempsey PJ, and Polk DB. ADAM17 is required for Helicobacter pylori-dependent EGFR and ErbB-3 transactivation in gastric epithelial cells. DDW meeting, Chicago, IL. 2005.

O’Brien D, Krishna U, Romero-Gallo J, Nedrud J, Medof E, Lin F, Redline R, Israel D, Franco A, and Peek RM. Molecular Mediators that Regulate Binding of Helicobacter pylori to Decay Accelerating Factor. ASM meeting, Atlanta, GA. 2005.

Franco AT, Israel DA, Washington MK, Fox JG, Rogers AB, Neish AS, Collier-Hyams L, Perez-Perez GI, Hatakeyama M, Whitehead R, Krishna US, Gaus K, O’Brien DP, and Peek RM. Gerbil-adapted H. pylori induces gastric cancer and activates ß-catenin. ASM meeting, Atlanta, GA. 2005.

Franco AT, Israel DA, Washington MK, Fox JG, Rogers AB, Neish AS, Collier-Hyams L, Perez-Perez GI, Hatakeyama M, Whitehead R, Krishna US, Gaus K, O’Brien DP, and Peek RM. Gerbil-adapted H. pylori induces gastric cancer and activates ß-catenin. ASM meeting, Atlanta, GA. 2005.

Ogden SR, Krishna US, Israel DA, Fingleton B, Matrisian LM, Crawford HC, and Peek RM. Helicobacter pylori induction of matrix metalloproteinase-7. ASM meeting, Atlanta, GA. 2005.

Takeuchi H, Israel D, Peek RM, Nakamura Y, Yanai H, Morimoto N, and Sugiura T. The effect of colonization of cdrA (cell division-related gene)-disrupted Helicobacter pylori to host response in human stomach. ASM meeting, Atlanta, GA. 2005.

O’Brien D, Krishna U, Nedrud J, Medof E, Lin F, Redline R, Israel D, Franco A, and Peek RM. The role of decay-accelerating factor as a receptor for Helicobacter pylori and a mediator of gastric inflammation. 13th International Workshop on Campylobacter, Helicobacter and related organisms, Brisbane, Australia. 2005.

Peek RM.. Orchestration of aberrant epithelial signaling by Helicobacter pylori CagA. Science STKE. 2005; 277: 1-3.

Keates S, Keates A, Nath S, Peek RM, & Kelly CP. Transactivation of the EGFR by cag+ Helicobacter pylori induces up-regulation of the early growth response gene Egr-1 in gastric epithelial cells. Gut. 2005; 54: 1363-9.

McNulty SL, Mole BM, Dailidiene D, Segal I, Ally R, Mistry R, Secka O, Adegbola RA, Thomas JE, Lenarcic EM, Peek RM, Berg DE, Forsyth MH. Novel 180- and 480-base-pair insertions in African and African-American strains of Helicobacter pylori. J. Clin. Microbiol. 2004 Dec; 42(12): 5658-63. PMID: 15583296, PMCID: PMC535299, PII: 42/12/5658, DOI: 10.1128/JCM.42.12.5658-5663.2004, ISSN: 0095-1137.

Peek RM. Intestinal malignancy and campylobacter jejuni. Gastroenterology. 2004 Oct; 127(4): 1266-7; discussion 1267. PMID: 15481007, PII: S0016508504014453, ISSN: 0016-5085.

Peek RM. Prevention of colorectal cancer through the use of COX-2 selective inhibitors. Cancer Chemother. Pharmacol. 2004 Sep; 54 Suppl 1: S50-6. PMID: 15309515, DOI: 10.1007/s00280-004-0887-x, ISSN: 0344-5704.

Peek RM. Clandestine intracellular delivery of Helicobacter pylori CagA: guess who's coming to dinner? [editorial]. Gastroenterology. 2004 Aug; 127(2): 669-72. PMID: 15300598, PII: S0016508504011448, ISSN: 0016-5085.

Peek RM. Eradication of Helicobacter pylori as a means towards eliminating gastric adenocarcinoma. Gastroenterology. 2004 Jul; 127(1): 344-6. PMID: 15236207, PII: S0016508504009680, ISSN: 0016-5085.

Gewirtz AT, Yu Y, Krishna US, Israel DA, Lyons SL, Peek RM. Helicobacter pylori flagellin evades toll-like receptor 5-mediated innate immunity. J. Infect. Dis [print-electronic]. 2004 May 5/15/2004; 189(10): 1914-20. PMID: 15122529, PII: JID31638, DOI: 10.1086/386289, ISSN: 0022-1899.

Peek RM. The past determines the future. Gastroenterology. 2004 Apr; 126(4): 1202-4. PMID: 15057761, PII: S0016508504003270, ISSN: 0016-5085.

Peek RM. Helicobacter pylori and Gastroesophageal Reflux Disease. Curr Treat Options Gastroenterol. 2004 Feb; 7(1): 59-70. PMID: 14723839, ISSN: 1092-8472.

Peek RM. Molecular hijacking and intracellular chaos. Gastroenterology. 2004 Feb; 126(2): 613-4; discussion 614. PMID: 14762802, PII: S001650850302105X, ISSN: 0016-5085.

Franco A, Krishna U, and Peek RM. Helicobacter pylori induces aberrant beta-catenin signaling in gastric epithelial cells. DDW meeting, New Orleans, LA. 2004.

O’Brien D, Nedrud J, Medof E, Lin F, Redline R, Franco A, Krishna U, and Peek RM. PPARγ activation induces the expression of a novel target gene, decay accelerating factor, that mediates Helicobacter pylori-induced inflammation. DDW meeting, New Orleans, LA. 2004.

O’Brien D, Nedrud J, Medof E, Lin F, Redline R, Franco A, Krishna U, and Peek RM. Helicobacter pylori-induced inflammation is mediated by a novel PPARγ target gene, decay accelerating factor. ASM meeting, New Orleans, LA. 2004.

Keates S, Keates AC, Peek RM, and Kelly CP. Up-regulation of the immediate early gene Egr-1 in H. pylori-infected gastric epithelial cells. DDW meeting, New Orleans, LA. 2004.

Terry CE, McGinnis LM, Peek RM, and Forsyth MH. Comparative genomics of cag-PAI positive and cag-PAI negative Helicobacter pylori isolates: identification of novel markers for cag-PAI positive strains. ASM meeting, New Orleans, LA. 2004.

Liu H, Semino-Mora C, Mog SR, Olsen C, Peek RM, and Dubois A. Effect of Helicobacter pylori infection on expression of IL-ß and of the DNA repair gene MGMT in rhesus monkeys. DDW meeting, New Orleans, LA. 2004.

Yu Y, Sitaraman S, Moore D, Merlin D, Williams I, Peek RM, and Gewirtz AT. TLR5 activation and T-cells are required for generating flagellin-specific immunoglobulin. DDW meeting, New Orleans, LA. 2004.

Xu H, Chaturvedi R, Cheng Y, Fertel D, Bussiere F, Asim M, Peek RM, and Wilson KT. H. pylori-induced gastric epithelial cell apoptosis and DNA damage is caused by polyamine oxidation. DDW meeting, New Orleans, LA. 2004.

Perez-Perez GI, Horstman NK, Olivares AZ, Peek RM, and Blaser MJ. Evolutionary development of Helicobacter pylori strains from Africa. European Helicobacter pylori Study Group, Vienna, Austria. 2004.

McNulty SL, Mole BM, Segal I, Dailidiene D, Secka O, Adegbola R, Thomas J, Peek RM, Berg DE, and Forsyth MH. Global analysis of Helicobacter pylori isolates identifies a novel 180 bp insertion/deletion significantly associated with African and African-American strains. ASM meeting, New Orleans, LA. 2004.

Peek RM. Preventing colitis through alteration of the intestinal biota. Gastroenterology. 2004 Jan; 126(1): 353-5; discussion 355. PMID: 14699516, PII: S0016508503018742, ISSN: 0016-5085.

Duck WM, Sobel J, Pruckler JM, Song Q, Swerdlow D, Friedman C, Sulka A, Swaminathan B, Taylor T, Hoestra M, Griffin P, Smoot D, Peek RM, Metz DC, Bloom PB, Goldschmidt S, Dunne D, Parsonnet J, Triadafilopoulos G, Perez-Perez GI, Cutler A, Vakil N, Ernst P, Czinn S, and Gold BD. Antimicrobial resistance rates and risk factors for antimicrobial resistance in Helicobacter pylori infection in a prospective multi-center study in the United States. Emerging Infectious Diseases. 2004; 10: 1088-94.

Peek RM.. Molecular hijacking and intracellular chaos. Gastroenterology. 2004; 126: 613-4.

Peek RM.. Intestinal malignancy and Campylobacter jejuni. Gastroenterology. 2004; 127: 1266-7.

Crawford HC, Krishna US, Israel DA, Matrisian LM, Washington MK, Peek RM. Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa. Gastroenterology. 2003 Oct; 125(4): 1125-36. PMID: 14517796, PII: S001650850301206X, ISSN: 0016-5085.

Peek RM. The role of PPARgamma in colon cancer: is it as simple as APC?. Gastroenterology. 2003 Aug; 125(2): 619-21. PMID: 12891569, PII: S0016508503009673, ISSN: 0016-5085.

Fox JG, Wang TC, Rogers AB, Poutahidis T, Ge Z, Taylor N, Dangler CA, Israel DA, Krishna U, Gaus K, Peek RM. Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology. 2003 Jun; 124(7): 1879-90. PMID: 12806621, PII: S0016508503004062, ISSN: 0016-5085.

Peek RM. Suppression of pathogenesis: bacteria lead the way. Gastroenterology. 2003 May; 124(5): 1550-2; discussion 1552. PMID: 15534984, ISSN: 0016-5085.

Cover TL, Krishna US, Israel DA, Peek RM. Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer Res. 2003 Mar 3/1/2003; 63(5): 951-7. PMID: 12615708, ISSN: 0008-5472.

Peek RM. Intoxicated cells and stomach ulcers. Nature genetics. 2003 Mar; 33(3) Sect. 328,30.

Gupta RA, Krishna U, Gaus K, Shappell S, Israel DA, DuBois RN, and Peek RM. PPARγ activation inhibits Helicobacter pylori-induced host inflammatory responses in vivo and in vitro. PPARs: Transcriptional Regulators of Metabolism and Metabolic Disease. Keystone Symposia, Keystone, CO. 2003.

Fox JG, Wang TC, Rogers AB, Poutahidis T, Ge Z, Taylor N, Dangler CA, Israel DA, Krishna US, Gaus K, and Peek RM. Host and microbial determinants influence Helicobacter pylori-induced gastric carcinogenesis in a murine model of hypergastrinemia. DDW meeting, Orlando, FL. 2003.

Gewirtz AT, Krishna US, Israel DA, Yu Y, and Peek RM. Helicobacter pylori evades Toll-like receptor 5 innate immunity. DDW meeting, Orlando, FL. 2003.

Israel DA, and Peek RM. Amplification-based enrichment for genes associated with carcinogenic Helicobacter pylori strains. ASM meeting, Washington, D.C. 2003.

Keates S, Keates AC, Sougioultzis S, Peek RM, and Kelly CP. Helicobacter pylori activates Akt via transactivation of the EGF receptor in AGS gastric epithelial cells. DDW meeting, Orlando, FL. 2003.

Ando T, Aras RA, Kusugami K, Peek RM, Blaser MJ, and Wassenaar T. Presence of hrgA and hrgB (iceA2) are differentially associated with Helicobacter pylori virulence. DDW meeting, Orlando, FL. 2003.

Li Y, Gaus K, Peek RM, and Cover TL. Role of VacA in Helicobacter pylori colonization of mice. ASM meeting, Washington, D.C. 2003.

Gupta RA, Krishna U, Gaus K, Shappell S, Israel DA, DuBois RN, and Peek RM. PPARγ suppresses Helicobacter pylori-induced host inflammatory responses. American Society for Clinical Investigation meeting, Chicago, IL. 2003.

Gewirtz AT, Yu Y, Krishna US, Israel DA, Lyons S, and Peek RM. Mechanisms though which Helicobacter pylori evades recognition by the host innate immune response. 12th International Workshop on Campylobacter, Helicobacter and related organisms, Aarhus, Denmark. 2003.

Mizuno T, Ando T, Nobata K, Tsuzuki T, Ina K, Kusugami K, Peek RM, and Goto H. Interleukin (IL)-17 and IL-8 levels in Helicobacter pylori-infected gastric mucosa are concordant. European Helicobacter pylori Study Group, Stockholm, Sweden. 2003.

Aras RA, Lee Y-C, Peek RM, and Blaser MJ. Natural variation in populations of persistently colonizing Helicobacter pylori. The Journal of Infectious Diseases. 2003; 188(()): 486-96.

Israel DA and Peek RM.. Application of microarray analysis to the investigation of host-pathogen interactions. In: Hecht GA, editor. Microbial pathogenesis and the intestinal epithelial cell. ASM press, Washington D.C. 2003; 121-40.

El-Omar E and Peek RM. Rapid Reference to Dyspepsia. Harcourt Publishers, London, U.K. 2003.

Lamarque D and Peek RM.. Helicobacter pylori pathogenesis. Helicobacter. 2003; 8: 21-30.

Peek RM.. The politics of H. pylori-challenged mice: liberal permissiveness versus conservative restriction. Gastroenterology. 2003; 124: 577-8.

Peek RM.. The superiority of proton pump inhibitor-based regimens for Helicobacter pylori eradication. Evidence-Based. Gastroenterology. 2003; 4: 46-7.

Graham JE, Peek RM, Krishna U, Cover TL. Global analysis of Helicobacter pylori gene expression in human gastric mucosa. Gastroenterology. 2002 Nov; 123(5): 1637-48. PMID: 12404238, PMCID: PMC1361305, PII: S0016508502002974, ISSN: 0016-5085.

Peek RM. New insights into microbially initiated gastric malignancies: beyond the usual suspects. Gastroenterology. 2002 Nov; 123(5): 1739-40; discussion 1740. PMID: 12404251, PII: S0016508502003104, ISSN: 0016-5085.

Takeuchi H, Israel DA, Miller GG, Donahue JP, Krishna U, Gaus K, Peek RM. Characterization of expression of a functionally conserved Helicobacter pylori methyltransferase-encoding gene within inflamed mucosa and during in vitro growth. J. Infect. Dis [print-electronic]. 2002 Oct 10/15/2002; 186(8): 1186-9. PMID: 12355374, PII: JID020491, DOI: 10.1086/343810, ISSN: 0022-1899.

Nozawa Y, Nishihara K, Peek RM, Nakano M, Uji T, Ajioka H, Matsuura N, Miyake H. Identification of a signaling cascade for interleukin-8 production by Helicobacter pylori in human gastric epithelial cells. Biochem. Pharmacol. 2002 Jul 7/1/2002; 64(1): 21-30. PMID: 12106602, PII: S0006295202010304, ISSN: 0006-2952.

Peek RM. Persistence and pathogenesis: a great defense facilitates a good offense. Gastroenterology. 2002 Jun; 122(7): 2084-5. PMID: 12078668, ISSN: 0016-5085.

Ando T, Wassenaar TM, Peek RM, Aras RA, Tschumi AI, van Doorn LJ, Kusugami K, Blaser MJ. A Helicobacter pylori restriction endonuclease-replacing gene, hrgA, is associated with gastric cancer in Asian strains. Cancer Res. 2002 Apr 4/15/2002; 62(8): 2385-9. PMID: 11956101, ISSN: 0008-5472.

Grady WM, Peek RM. Hereditary diffuse gastric cancer: more answers or more questions?. Gastroenterology. 2002 Mar; 122(3): 830-1; discussion 831. PMID: 11875020, PII: S0016508502164249, ISSN: 0016-5085.

Goldblum JR, Richter JE, Vaezi M, Falk GW, Rice TW, Peek RM. Helicobacter pylori infection, not gastroesophageal reflux, is the major cause of inflammation and intestinal metaplasia of gastric cardiac mucosa. Am. J. Gastroenterol. 2002 Feb; 97(2): 302-11. PMID: 11866266, DOI: 10.1111/j.1572-0241.2002.05462.x, ISSN: 0002-9270.

Crawford HC, Krishna US, and Peek RM. Helicobacter pylori strain-selective induction of the tumor-associated metalloproteinase matrilysin is dependent upon cag-mediated activation of NFB and MAPK. DDW meeting, San Francisco, CA. 2002.

Graham JE, Peek RM, and Cover TL. Analysis of Helicobacter pylori gene expression in human gastric mucosa. ASM meeting, Salt Lake City, Utah. 2002.

Takeuchi H, Donahue JP, Krishna U, Miller GG, Peek RM, and Israel DA. Quantitative detection of expression of the Helicobacter pylori methyltransferase-encoding gene hpy1M in vivo and in vitro. ASM meeting, Salt Lake City, Utah. 2002.

Perez-Perez GI, Olivares AZ, Peek RM, Tham K, and Blaser MJ. Detection of Helicobacter pylori in gastric juice by PCR. European Helicobacter pylori Study Group, Athens, Greece. 2002.

Peek RM. Helicobacter pylori strain-specific modulation of gastric mucosal cellular turnover: implications for carcinogenesis. J. Gastroenterol. 2002; 37 Suppl 13: 10-6. PMID: 12109657, ISSN: 0944-1174.

Peek RM, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat. Rev. Cancer. 2002 Jan; 2(1): 28-37. PMID: 11902583, DOI: 10.1038/nrc703, ISSN: 1474-175X.

Peek RM. Elimination of Helicobacter pylori or acid in high-risk users of aspirin or nonsteroidal medications: final answer?. Gastroenterology. 2002 Jan; 122(1): 238-40. PMID: 11781303, PII: S0016508502437407, ISSN: 0016-5085.

Ando T, Peek RM, Lee YC, Krishna U, Kusugami K, Blaser MJ. Host cell responses to genotypically similar Helicobacter pylori isolates from United States and Japan. Clin. Diagn. Lab. Immunol. 2002 Jan; 9(1): 167-75. PMID: 11777849, PMCID: PMC119904, ISSN: 1071-412X.

Ando T, Peek RM, Pride D, Levine S, Takata T, Kusugami K, van der Ende A, Kuipers EJ, Kusters JG, and Blaser MJ.. Polymorphisms of Helicobacter pylori HP0638 reflect strain geographic origin and correlate with cagA status. J. Clin. Microbiol. 2002; 40: 239-46.

Ando T, Peek RM, Lee Y-C, Krishna U, Kusugami K, and Blaser MJ.. Host cell responses to genotypically similar Helicobacter pylori isolates from the United States and Japan. Clin. Diag. Lab. Immunol. 2002; 9: 167-75.

Peek RM.. New insights into microbially-initiated gastric malignancies: beyond the usual suspects. Gastroenterology. 2002; 123: 1739-40.

Peek RM.. Is CagA ready for prime time? Evidence-Based. Gastroenterology. 2002; 3: 78-9.

Gupta RA, Krishna US, Gaus K, Shappell S, Israel DA, Tham KT, DuBois RN, and Peek RM. PPARγ activation inhibits Helicobacter pylori-induced host inflammatory responses in vivo and in vitro. DDW meeting, San Francisco, CA. 2002.

Israel DA, Salama N, Krishna U, Rieger UM, Atherton JC, Falkow S, Peek RM. Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2001 Dec 12/4/2001; 98(25): 14625-30. PMID: 11724955, PMCID: PMC64732, PII: 251551698, DOI: 10.1073/pnas.251551698, ISSN: 0027-8424.

Israel DA, Peek RM. Pathogenesis of Helicobacter pylori-induced gastric inflammation. Aliment. Pharmacol. Ther. 2001 Sep; 15(9): 1271-90. PMID: 11552897, PII: apt1052, ISSN: 0269-2813.

Gupta RA, Polk DB, Krishna U, Israel DA, Yan F, DuBois RN, Peek RM. Activation of peroxisome proliferator-activated receptor gamma suppresses nuclear factor kappa B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J. Biol. Chem [print-electronic]. 2001 Aug 8/17/2001; 276(33): 31059-66. PMID: 11397815, PII: M104141200, DOI: 10.1074/jbc.M104141200, ISSN: 0021-9258.

Peek RM. The biological impact of Helicobacter pylori colonization. Semin. Gastrointest. Dis. 2001 Jul; 12(3): 151-66. PMID: 11478748, ISSN: 1049-5118.

Peek RM. IV. Helicobacter pylori strain-specific activation of signal transduction cascades related to gastric inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 2001 Apr; 280(4): G525-30. PMID: 11254477, ISSN: 0193-1857.

Tham KT, Peek RM, Atherton JC, Cover TL, Perez-Perez GI, Shyr Y, Blaser MJ. Helicobacter pylori genotypes, host factors, and gastric mucosal histopathology in peptic ulcer disease. Hum. Pathol. 2001 Mar; 32(3): 264-73. PMID: 11274634, PII: S0046-8177(01)25759-1, DOI: 10.1053/hupa.2001.21136, ISSN: 0046-8177.

Israel DA, Salama N, Arnold CN, Moss SF, Ando T, Wirth HP, Tham KT, Camorlinga M, Blaser MJ, Falkow S, Peek RM. Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses. J. Clin. Invest. 2001 Mar; 107(5): 611-20. PMID: 11238562, PMCID: PMC199426, DOI: 10.1172/JCI11450, ISSN: 0021-9738.

Israel DA, Salama N, Krishna U, Falkow S, and Peek RM. Characterization of Helicobacter pylori genetic evolution within a single human host. ASM meeting, Orlando, FL. 2001.

Israel DA, Salama N, Arnold CN, Moss SF, Ando T, Wirth HP, Tham KT, Camorlinga M, Falkow S, and Peek RM. Helicobacter pylori whole genome microarray identifies differences in genetic composition related to pathogenesis among strains that induce distinct clinical outcomes. DDW meeting, Atlanta, GA. 2001.

Israel DA, Salama N, Atherton JC, Krishna U, Falkow S, and Peek RM. Characterization of phenotypic and genotypic evolution among isolates of Helicobacter pylori strain J99 obtained years apart from the source human host. DDW meeting, Atlanta, GA. 2001.

Goldblum Jr, Richter JE, Vaezi MF, Falk GW, Rice TR, and Peek RM. H. pylori (HP), not GERD, is the major cause of inflammation and intestinal metaplasia (IM) of the native gastric cardia. DDW meeting, Atlanta, GA. 2001.

Ando T, Peek RM, Kusugami K, Van Doorn LJ, Wassenaar T, Kim SK, and Blaser MJ. H. pylori strains with the novel gene MboX are correlated with gastric cancer in Asian patients. DDW meeting, Atlanta, GA. 2001.

Ando T, Peek RM, Levine S, Kusugami K, Lee YC, van der Ende A, Kusters JG, Takata T, and Blaser MJ. Diversity of Helicobacter pylori HP0638, encoding OipA, correlates with cagA status and geographic origin. DDW meeting, Atlanta, GA. 2001.

Ando T, Peek RM, Kusugami K, and Blaser MJ. Comparison of IL-8 and apoptosis induction by cagA+ vacA s1/m1 H. pylori strains from the US and Japan. DDW meeting, Atlanta, GA. 2001.

Keates S, Sougioultzis S, Keates AC, Warny M, Peek RM, and Kelly CP. H. pylori activates the EGF receptor to regulate IL-8 gene expression in AGS gastric epithelial cells. DDW meeting, Atlanta, GA. 2001.

Gupta RA, Polk DB, Krishna U, Israel DA, Yan F, DuBois RN, and Peek RM. Activation of PPAR suppresses NF-B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. FASEB meeting: Gastrointestinal Tract IX: Mechanisms of Disease and Protection, Whitefish, MT. 2001.

Israel DA, Salama N, Atherton JC, Krishna US, Falkow S, and Peek RM. Comprehensive characterization of genetic diversity among Helicobacter pylori isolates obtained years apart from a single human host. 11th International Workshop on Campylobacter, Helicobacter and related organisms, Freiburg, Germany. 2001.

Donahue JP, and Peek RM.. Restriction and modification systems. In: Hazell S, Mendz G, Mobley H, editors. Helicobacter pylori. ASM press, Washington D.C. 2001; 269-76.

Peek RM.. Molecular dissection of the mechanisms through which Enteropathogenic Escherichia coli induce diarrhea. Gastroenterology. 2001; 121: 496-7.

Keates S, Sougioultzis S, Keates AC, Zhao D, Peek RM, Shaw LM, and Kelly CP.. Cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells. J. Biol. Chem. 2001; 276: 48127-34.

Kidd M, Peek RM, Lastovica AJ, Israel DA, Kummer AF, and Louw JA.. Analysis of iceA genotypes in South African Helicobacter pylori strains and relationship to clinically significant disease. Gut. 2001; 49: 629-35.

Iwase H, Maeda O, Shimada M, Tsuzuki T, Peek RM, Nishio Y, Ando T, Ina K, and Kusugami K.. Endoscopic ablation with cyanoacrylate glue for isolated gastric variceal bleeding. Gastrointestinal Endoscopy. 2001; 53: 585-92.

Peek RM.. Helicobacter pylori, aspirin, and nonsteroidal medications, and complications of ulcer disease: seeing through the glass less dimly? Evidence-Based. Gastroenterology. 2001; 2: 58-60.

Peek RM, van Doorn LJ, Donahue JP, Tham KT, Figueiredo C, Blaser MJ, Miller GG. Quantitative detection of Helicobacter pylori gene expression in vivo and relationship to gastric pathology. Infect. Immun. 2000 Oct; 68(10): 5488-95. PMID: 10992444, PMCID: PMC101496, ISSN: 0019-9567.

Donahue JP, Israel DA, Peek RM, Blaser MJ, Miller GG. Overcoming the restriction barrier to plasmid transformation of Helicobacter pylori. Mol. Microbiol. 2000 Sep; 37(5): 1066-74. PMID: 10972825, PII: mmi2036, ISSN: 0950-382X.

Donahue JP, Peek RM, Van Doorn LJ, Thompson SA, Xu Q, Blaser MJ, Miller GG. Analysis of iceA1 transcription in Helicobacter pylori. Helicobacter. 2000 Mar; 5(1): 1-12. PMID: 10672045, PMCID: PMC2779704, PII: he8, ISSN: 1083-4389.

Peek RM, Wirth HP, Tham KT, Richmond HT, Ando T, Kim SK, Blaser MJ, and Moss SF. Infection of Mongolian gerbils with H. pylori strains associated with differential cancer risks reflects the pathologic response of the human host. DDW meeting, San Diego, CA. 2000.

Peek RM, Gupta RA, Krishna U, and DuBois RN. Helicobacter pylori cagA+ strain-induced apoptosis is attenuated by activation of PPAR. DDW meeting, San Diego, CA. 2000.

Perez-Perez GI, Legath A, Peek RM, Tham KT, and Blaser MJ. Serum pepsinogens in relation to H. pylori status and genotype and gastric inflammatory cell infiltration. DDW meeting, San Diego, CA. 2000.

Peek RM, Wirth HP, Moss SF, Yang M, Abdalla AM, Tham KT, Zhang T, Tang LH, Modlin IM, Blaser MJ. Helicobacter pylori alters gastric epithelial cell cycle events and gastrin secretion in Mongolian gerbils. Gastroenterology. 2000 Jan; 118(1): 48-59. PMID: 10611153, PII: S0016508500240298, ISSN: 0016-5085.

Figueiredo C, Quint WGV, Sanna R, Sablon E, Donahue JP, Xu Q, Miller GG, Peek RM, Blaser MJ, and van Doorn LJ. Genetic organization and heterogeneity of the iceA locus of Helicobacter pylori. Gene. 2000; 24: 59-68.

Iwase H, Kusugami K, Suzuki M, Nishio Y, Ando T, Ina K, and Peek RM.. Endoscopic resection of early-stage esophageal cancer accompanied by esophageal varices. Gastrointestinal Endoscopy. 2000; 51: 749-52.

Vaezi MF, Falk GW, Peek RM, Vicari JJ, Goldblum JR, Perez-Perez GI, Rice TW, Blaser MJ, and Richter JE.. CagA positive strains of Helicobacter pylori may protect against Barrett's esophagus. Am. J. Gastro. 2000; 95: 2206-11.

Peek RM, Blaser MJ, Mays DJ, Forsyth MH, Cover TL, Song SY, Krishna U, Pietenpol JA. Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle. Cancer Res. 1999 Dec 12/15/1999; 59(24): 6124-31. PMID: 10626802, ISSN: 0008-5472.

Perez-Perez GI, Peek RM, Legath AJ, Heine PR, Graff LB. The role of CagA status in gastric and extragastric complications of Helicobacter pylori. J. Physiol. Pharmacol. 1999 Dec; 50(5): 833-45. PMID: 10695563, ISSN: 0867-5910.

Peek RM, Vaezi MF, Falk GW, Goldblum JR, Perez-Perez GI, Richter JE, Blaser MJ. Role of Helicobacter pylori cagA(+) strains and specific host immune responses on the development of premalignant and malignant lesions in the gastric cardia. Int. J. Cancer. 1999 Aug 8/12/1999; 82(4): 520-4. PMID: 10404065, PII: 10.1002/(SICI)1097-0215(19990812)82:4<520::AID-IJC9>3.0.CO;2-7, ISSN: 0020-7136.

Perez-Perez GI, Peek RM, Atherton JC, Blaser MJ, Cover TL. Detection of anti-VacA antibody responses in serum and gastric juice samples using type s1/m1 and s2/m2 Helicobacter pylori VacA antigens. Clin. Diagn. Lab. Immunol. 1999 Jul; 6(4): 489-93. PMID: 10391848, PMCID: PMC95713, ISSN: 1071-412X.

Wirth HP, Yang M, Peek RM, Höök-Nikanne J, Fried M, Blaser MJ. Phenotypic diversity in Lewis expression of Helicobacter pylori isolates from the same host. J. Lab. Clin. Med. 1999 May; 133(5): 488-500. PMID: 10235132, PII: S0022-2143(99)90026-4, ISSN: 0022-2143.

Peek RM, Blaser MJ, Mays DJ, Forsyth MH, Cover TL, Song SY, and Pietenpol JA. Helicobacter pylori cag+ Strains Modulate the Gastric Epithelial Cell Cycle by picB- and vacA-dependent mechanisms. DDW meeting, Orlando, FL. 1999.

Peek RM, Wirth HP, Moss SF, Abdalla AM, Voodarla A, Yang M, Zhang T, Tang LH, Modlin IM, Tham KT, and Blaser MJ. Experimental Infection with Helicobacter pylori Alters Gastric Epithelial Cell Cycle Events and Gastrin Secretion in Mongolian Gerbils, Independent of cagA or vacA. DDW meeting, Orlando, FL. 1999.

Peek RM, van Doorn LJ, Donahue JP, Tham KT, Blaser MJ, and Miller GG. Helicobacter pylori iceA is Transcribed in vivo and iceA1 Expression is Associated with Enhanced Acute Mucosal Inflammation. DDW meeting, Orlando, FL. 1999.

Peek RM, Vaezi MF, Falk GW, Del Valle J, Goldblum JR, Perez-Perez GI, Richter JE, and Blaser MJ. The role of Helicobacter pylori cagA+ strains and gastrin secretion on the development of premalignant and malignant lesions in the gastric cardia. DDW meeting, Orlando, FL. 1999.

Peek RM, Blaser MJ, and Pietenpol JA. H. pylori cag+ Strains Selectively Modulate Cell Cycle Progression and Induce Apoptosis in Human Gastric Epithelial Cells Containing Wild-type p53. Keystone Symposia, Keystone, CO. 1999.

Peek RM, Blaser MJ, Forsyth MH, Cover TL, and Pietenpol JA. Helicobacter pylori strain-specific genotypes and p53-mediated pathways in modulation of the cell cycle. European Helicobacter pylori Study Group, Helsinki, Finland. 1999.

Perez-Perez GI, Gaensbauer J, Bhat N, Tham KT, Peek RM, and Blaser MJ. Correlates of gastric body inflammation based on humoral responses to H. pylori and cagA antigens. DDW meeting, Orlando, FL. 1999.

Vaezi MF, Vicari JJ, Falk GW, Peek RM, Goldblum JR, Rice TW, Perez-Perez GI, O’Conner JB, Blaser MJ, and Richter JE. CagA+ H. pylori colonization may prevent Barrett’s esophagus. DDW meeting, Orlando, FL. 1999.

Vicari JJ, Falk GW, Vaezi MF, Peek RM, Blaser MJ, and Richter JE. CagA positivity may be protective against more severe grades of esophagitis. DDW meeting, Orlando, FL. 1999.

Donahue JP, Peek RM, van Doorn LJ, Thompson SA, Xu Q, Blaser MJ, and Miller GG. Multiple Transcripts Derive From the Helicobacter pylori iceA1 Locus. ASM meeting, Chicago IL. 1999.

Keates S, Keates AC, Peek RM, and Kelly CP. Cag+ and Cag- H. pylori Strains Differ in Their Ability to Activate MAPKinases in AGS Gastric Epithelial Cells. DDW meeting, Orlando, FL. 1999.

Keates S, Keates AC, Warny M, Peek RM, Murray PG, and Kelly CP.. Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori. J. Immunol. 1999; 163: 5552-55529.

Hayakawa M, Shimokawa K, Kusugami K, Sugihara M, Morooka Y, Fujita T, Nakamura M, Nishio Y, Maeda K, Ando T, and Peek RM.. Clinicopathological features of superficial depressed-type colorectal neoplastic lesions. Am. J. Gastro. 1999; 94: 944-9.

Atherton JC, Sharp PM, Cover TL, Gonzales-Valencia G, Peek RM, Thompson SA, Hawkey CJ, and Blaser MJ.. Vacuolating cytotoxin (vacA) alleles of Helicobacter pylori comprise two geographically widespread types, ml and m2, and have evolved through limited recombination. Current Microbiol. 1999; 39: 211-8.

Peek RM, Thompson SA, Donahue JP, Tham KT, Atherton JC, Blaser MJ, Miller GG. Adherence to gastric epithelial cells induces expression of a Helicobacter pylori gene, iceA, that is associated with clinical outcome. Proc. Assoc. Am. Physicians. 1998 Nov; 110(6): 531-44. PMID: 9824536, ISSN: 1081-650X.

Höök-Nikanne J, Berg DE, Peek RM, Kersulyte D, Tummuru MK, Blaser MJ. DNA sequence conservation and diversity in transposable element IS605 of Helicobacter pylori. Helicobacter. 1998 Jun; 3(2): 79-85. PMID: 9631304, ISSN: 1083-4389.

Peek RM, Moss SF, Cover TL, Wirth HP, Tham KT, Atherton JC, Holt PR, and Blaser MJ. Helicobacter pylori vacA s1a strains attenuate apoptosis in vitro and in vivo through a toxin-independent mechanism. DDW meeting, New Orleans, LA. 1998.

Peek RM, Vaezi MF, Goldblum JR, Falk GW, Vicari JJ, Perez-Perez GI, RiceTW, Richter JE, Sechopoulos P, and Blaser MJ. Seropositivity to CagA, HspA, and IgA identifies Helicobacter pylori strains that induce premalignant changes in the gastric cardia but not in the esophagus. DDW meeting, New Orleans, LA. 1998.

Vicari JJ, Peek RM, Falk GW, Goldblum JR, Easley KA, Schnell J, Perez-Perez GI, Halter SA, Rice TW, Blaser MJ, and Richter JE.. The seroprevalence of cagA-positive Helicobacter pylori strains in the spectrum of gastroesophageal reflux disease. Gastroenterology. 1998; 115: 50-7.

Goldblum JR, Vicari JJ, Falk GW, Rice TW, Peek RM, Easley K, and Richter JE.. Inflammation and intestinal metaplasia of the gastric cardia: the role of gastroesophageal reflux and H. pylori infection. Gastroenterology. 1998; 114: 633-9.

Xu Q, Peek RM, Miller GG, Blaser MJ. The Helicobacter pylori genome is modified at CATG by the product of hpyIM. J. Bacteriol. 1997 Nov; 179(21): 6807-15. PMID: 9352933, PMCID: PMC179612, ISSN: 0021-9193.

Wirth HP, Yang M, Peek RM, Tham KT, Blaser MJ. Helicobacter pylori Lewis expression is related to the host Lewis phenotype. Gastroenterology. 1997 Oct; 113(4): 1091-8. PMID: 9322503, PII: S0016508597004605, ISSN: 0016-5085.

Peek RM, Moss SF, Tham KT, Pérez-Pérez GI, Wang S, Miller GG, Atherton JC, Holt PR, Blaser MJ. Helicobacter pylori cagA+ strains and dissociation of gastric epithelial cell proliferation from apoptosis. J. Natl. Cancer Inst. 1997 Jun 6/18/1997; 89(12): 863-8. PMID: 9196252, ISSN: 0027-8874.

Peek RM, Kerr LD, Miller GG, and Blaser MJ. H. pylori induce apoptosis in gastric epithelial cells by an NF-kB-independent mechanism. European Helicobacter pylori Study Group, Lisbon, Portugal. 1997.

Wirth HP, Yang M, Peek RM, Tham KT, and Blaser MJ. The host serum antibody response to H. pylori polysaccharides of different Lewis type is unrelated to the bacterial or host Lewis phenotype. DDW meeting, Washington, D.C. 1997.

Vicari JJ, Falk GW, Goldblum JR, Easley K, Peek RM, Perez-Perez GI, Halter SA, Schnell J, Rice TW, Blaser, MJ, and Richter JE. H. pylori is not a pathogenic factor in GERD or its complications. DDW meeting, Washington, D.C. 1997.

Perez-Perez GI, Tham KT, Peek RM, Atherton JC, and Blaser MJ. Not all Helicobacter pylori- infected persons produce specific IgA in gastric juice. DDW meeting, Washington, D.C. 1997.

Wirth HP, Yang M, Peek RM, Tham KT, and Blaser MJ. Helicobacter pylori Lewis expression is related to the host Lewis phenotype. DDW meeting, Washington, D.C. 1997.

Schnell JW, Vicari JJ, Perez-Perez GI, Falk GW, Halter SA, Goldblum JR, Gangarosa LM, Rice TW, Richter JE, Blaser MJ, and Peek RM. Helicobacter pylori cagA-strains predominate in gastroesophageal reflux disease, Barrett’s esophagus, and esophageal dysplasia/adenocarcinoma. DDW meeting, Washington, D.C. 1997.

Atherton JC, Twells RJ, Hawkey CJ, Peek RM, Cover TL, and Blaser MJ. New, internationally applicable, polymerase chain reaction-based typing of Helicobacter pylori vacA. DDW meeting, Washington, D.C. 1997.

Wirth HP, Yang M, Peek RM, Tham KT, and Blaser MJ. H. pylori Lewis expression: Relationship to host Lewis phenotype, antibody response to Lewis antigens, and gastric histopathology. European Helicobacter pylori Study Group, Lisbon, Portugal. 1997.

Perez-Perez GI, Tham KT, Peek RM, Atherton JC, Blaser MJ, and Cover TL. Serologic responses to type m1 and m2 H. pylori vacA antigens. European Helicobacter pylori Study Group, Lisbon, Portugal. 1997.

Peek RM, and Blaser MJ.. Pathophysiology of Helicobacter pylori-induced gastritis and peptic ulcer disease. Am. J. Med. 1997; 102: 200-7.

Peek RM, and Blaser MJ.. Helicobacter pylori, peptic ulcer disease and gastric cancer. Mechanisms of Microbial Disease. Williams and Wilkins. 1997.

Atherton JC, Peek RM, Tham KT, Cover TL, and Blaser MJ.. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology. 1997; 112: 92-9.

Sharma SA, Miller GG, Peek RM, Perez-Perez GI, and Blaser MJ.. T-cell, antibody, and cytokine responses to homologs of the 60-kilodalton heat shock protein in Helicobacter pylori infection. Clin. Diag. Lab. Immunol. 1997; 4: 440-6.

Atherton JC, Tham KT, Peek RM, Cover TL, Blaser MJ. Density of Helicobacter pylori infection in vivo as assessed by quantitative culture and histology. J. Infect. Dis. 1996 Sep; 174(3): 552-6. PMID: 8769613, ISSN: 0022-1899.

Peek RM, Thompson SA, Atherton JC, Blaser MJ, and Miller GG. Expression of a Novel Ulcer-Associated H. pylori Gene, iceA Following Adherence to Gastric Epithelial Cells. DDW meeting, San Francisco, CA. 1996.

Peek RM, Moss SF, Tham KT, Perez-Perez GI, Miller GG, Holt PR, and Blaser MJ. Infection with H. pylori cagA Strains Dissociates Gastric Epithelial Proliferation from Apoptosis. DDW meeting, San Francisco, CA. 1996.

Peek RM, Thompson SA, Atherton JC, Blaser MJ, and Miller GG. Expression of iceA, a Novel Ulcer Associated H. pylori Gene, is Induced by Contact with Gastric Epithelial Cells and is Associated with Enhanced Mucosal IL-8. IXth International Workshop Gastroduodenal Pathology and Helicobacter pylori. Copenhagen, Denmark. 1996.

Peek RM, Miller GG, Tham KT, Perez-Perez GI, Zhao X, Atherton JC, Blaser MJ. Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains. Lab. Invest. 1995 Dec; 73(6): 760-70. PMID: 8558837, ISSN: 0023-6837.

Atherton JC, Cao P, Peek RM, Tummuru MK, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J. Biol. Chem. 1995 Jul 7/28/1995; 270(30): 17771-7. PMID: 7629077, ISSN: 0021-9258.

Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, Stemmermann GN, Nomura A. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 1995 May 5/15/1995; 55(10): 2111-5. PMID: 7743510, ISSN: 0008-5472.

Peek RM, Miller GG, Tham KT, Perez-Perez GI, Zhao XM, Atherton JC, and Blaser MJ. Heightened Cytokine Expression and Inflammatory Response in vivo to cagA Helicobacter pylori Strains. DDW Meeting, San Diego, CA. 1995.

Peek RM, Atherton JC, Cover TL, Miller GG, and Blaser MJ. Association Between Gastric Mucosal IL-8 Levels and vacA Genotypes of Infecting Helicobacter pylori Strains. DDW meeting, San Diego, CA. 1995.

Atherton JC, Cao P, Peek RM, Blaser MJ, and Cover TL. Mosaicism in vacA, the Vacuolating Cytotoxin Gene of Helicobacter pylori, and Genetic Linkage of vacA Subtypes with cagA, the Cytotoxin-Associated Gene. DDW meeting, San Diego, CA. 1995.

Atherton JC, Cover TL, Peek RM, and Blaser MJ. Typing the Vacuolating Cytotoxin Gene (vacA) of Helicobacter pylori : Relationship with in vitro Cytotoxin Activity and Host Peptic Ulceration. DDW meeting, San Diego, CA. 1995.

Lewis TJ, Halter SA, Peek RM, and Davis RC. Massive GI Bleeding as a Manifestation of Whipple’s Disease. DDW meeting, San Diego, CA. 1995.

Peek RM, Thompson SA, Atherton JC, Blaser MJ, and Miller GG. Adherence-Induced Expression of a Novel Helicobacter pylori Gene and Correlation with Peptic Ulceration. European Helicobacter pylori Study Group, Edinburgh, Scotland. 1995.

Peek RM, Miller GG, Tham KT, Pérez-Pérez GI, Cover TL, Atherton JC, Dunn GD, Blaser MJ. Detection of Helicobacter pylori gene expression in human gastric mucosa. J. Clin. Microbiol. 1995 Jan; 33(1): 28-32. PMID: 7699060, PMCID: PMC227873, ISSN: 0095-1137.

Peek RM, Miller GG, and Blaser MJ.. Reverse transcription-Polymerase chain reaction (RT-PCR) for bacterial and host gene expression in human gastric mucosa. In: Lee, A., Megraud, F., editors. Helicobacter pylori: Techniques for Clinical Diagnosis and Basic Research. W.B. Saunders Ltd. 1995; 163-73.

Peek RM, Miller GM, Perez-Perez GI, Tham KT, Cover TL, Dunn D, and Blaser MJ.. Reverse Transcription and Polymerase Chain Reaction Detection of Helicobacter pylori in Gastric Biopsies in vivo and Expression of H. pylori Genes. DDW meeting, New Orleans, LA. 1994.

Peek RM, Blaser MJ, and Miller GI.. CagA-positive Helicobacter pylori Strains Induce Preferential Cytokine Expression in Gastric Mucosa. DDW meeting, New Orleans, LA. 1994.

Peek RM, Miller GG, Tham KT, Perez-Perez GI, Cover TL, Dunn D, and Blaser MJ.. Detection of cagA Expression in vivo and Demonstration of Preferential Cytokine Expression of cagA+ H. pylori Strains in Gastric Mucosa. European Helicobacter pylori Study Group, Houston, Texas. 1994.

Atherton JC, Peek RM, Tham KT, Perez-Perez GI, and Blaser MJ.. Quantitative Culture Shows that Density of Helicobacter pylori in the Gastric Antrum is Higher in Duodenal Ulcer Sufferers than Others and Correlates Positively with cagA Status and Negatively with Serum IgG Antibody Levels. European Helicobacter pylori Study Group, Houston, Texas. 1994.

Atherton JC, Cover TL, Peek RM, and Blaser MJ. Subtyping of Helicobacter pylori Strains Into Two Groups by Polymerase Chain Reaction of the vacA Gene and Correlation of these Groups with cagA Status. European Helicobacter pylori Study Group, Houston, Texas. 1994.

Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, and Nomura A. Infection with Helicobacter pylori Strains Possessing cagA is Associated with Increased Risk of Developing Adenocarcinoma of the Stomach among Japanese-American men in Hawaii. European Helicobacter pylori Study Group, Houston, Texas. 1994.

Peek RM, and Truss C.. Diarrhea following a dog bite. Dig. Dis. Sci. 1991; 36: 1151-3.

Wirth HP, Yang M, Peek RM, Hook-Nikanne J, and Blaser MJ. Phenotypic diversity in Lewis expression of single H. pylori colonies derived from the same biopsy. DDW meeting, Washington, D.C.