Mark A. Magnuson, M.D.

Professor

mark.magnuson@vanderbilt.edu

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Faculty Appointments
Professor of Molecular Physiology and Biophysics Louise B. McGavock ChairProfessor of MedicineProfessor of Cell and Developmental Biology
Education
M.D., Medicine, University of Iowa, Iowa City, IowaB.A., Biochemistry, Luther College, Decorah, Iowa
Office Address
Center for Stem Cell Biology
9465 MRB IV
Nashville, TN 37232-0494
Research Description
We are interested in developing new types of therapies for the treatment of diabetes. This requires a deep understanding of pancreatic beta cell function and development. My laboratory has a long history of developing novel mouse models using gene targeting and recombinase-mediated cassette exchange (RMCE) strategies, and using these mice to gain important new insights and understanding of the molecular physiology of diabetes. However, better models that more closely mimic the physiology and pathophysiology of human diseases, including type 1 and type 2 diabetes, are needed. Towards this end, we have been developing several novel strategies and methods that will enable us to generate better animal models that more closely model the human.
Research Keywords
pancreatic endocrine cell differentitation and dedifferentiation, reprogramming of pancreatic acinar cells into new beta cells, genetic and epigenetic regulation of cellular plasticity, mouse models, transcription factors, genomics, diabetes
Publications
Golson ML, Dunn JC, Maulis MF, Dadi PK, Osipovich AB, Magnuson MA, Jacobson DA, Gannon M. Activation of FoxM1 Revitalizes the Replicative Potential of Aged ß-Cells in Male Mice and Enhances Insulin Secretion. Diabetes [print-electronic]. 2015 Nov; 64(11): 3829-38. PMID: 26251404, PMCID: PMC4613976, PII: db15-0465, DOI: 10.2337/db15-0465, ISSN: 1939-327X.

Shih HP, Seymour PA, Patel NA, Xie R, Wang A, Liu PP, Yeo GW, Magnuson MA, Sander M. A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. Cell Rep [print-electronic]. 2015 Oct 10/13/2015; 13(2): 326-36. PMID: 26440894, PMCID: PMC4607666, PII: S2211-1247(15)01007-4, DOI: 10.1016/j.celrep.2015.08.082, ISSN: 2211-1247.

Sciarretta S, Zhai P, Maejima Y, Del Re DP, Nagarajan N, Yee D, Liu T, Magnuson MA, Volpe M, Frati G, Li H, Sadoshima J. MTORC2 regulates cardiac response to stress by inhibiting MST1. Cell Rep [print-electronic]. 2015 Apr 4/7/2015; 11(1): 125-36. PMID: 25843706, PMCID: PMC4417361, PII: S2211-1247(15)00263-6, DOI: 10.1016/j.celrep.2015.03.010, ISSN: 2211-1247.

Brouwers B, de Faudeur G, Osipovich AB, Goyvaerts L, Lemaire K, Boesmans L, Cauwelier EJ, Granvik M, Pruniau VP, Van Lommel L, Van Schoors J, Stancill JS, Smolders I, Goffin V, Binart N, in't Veld P, Declercq J, Magnuson MA, Creemers JW, Schuit F, Schraenen A. Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression. Cell Metab. 2014 Dec 12/2/2014; 20(6): 979-90. PMID: 25470546, PII: S1550-4131(14)00501-4, DOI: 10.1016/j.cmet.2014.11.004, ISSN: 1932-7420.

Willet SG, Hale MA, Grapin-Botton A, Magnuson MA, MacDonald RJ, Wright CV. Dominant and context-specific control of endodermal organ allocation by Ptf1a. Development. 2014 Nov; 141(22): 4385-94. PMID: 25371369, PMCID: PMC4302917, PII: 141/22/4385, DOI: 10.1242/dev.114165, ISSN: 1477-9129.

Osipovich AB, Long Q, Manduchi E, Gangula R, Hipkens SB, Schneider J, Okubo T, Stoeckert CJ, Takada S, Magnuson MA. Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development. 2014 Aug; 141(15): 2939-49. PMID: 25053427, PMCID: PMC4197673, PII: 141/15/2939, DOI: 10.1242/dev.104810, ISSN: 1477-9129.

Hang Y, Yamamoto T, Benninger RK, Brissova M, Guo M, Bush W, Piston DW, Powers AC, Magnuson M, Thurmond DC, Stein R. The MafA transcription factor becomes essential to islet ß-cells soon after birth. Diabetes [print-electronic]. 2014 Jun; 63(6): 1994-2005. PMID: 24520122, PMCID: PMC4030115, PII: db13-1001, DOI: 10.2337/db13-1001, ISSN: 1939-327X.

Tornovsky-Babeay S, Dadon D, Ziv O, Tzipilevich E, Kadosh T, Schyr-Ben Haroush R, Hija A, Stolovich-Rain M, Furth-Lavi J, Granot Z, Porat S, Philipson LH, Herold KC, Bhatti TR, Stanley C, Ashcroft FM, In't Veld P, Saada A, Magnuson MA, Glaser B, Dor Y. Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in ß cells. Cell Metab [print-electronic]. 2014 Jan 1/7/2014; 19(1): 109-21. PMID: 24332968, PII: S1550-4131(13)00456-7, DOI: 10.1016/j.cmet.2013.11.007, ISSN: 1932-7420.

Seto Y, Nakatani T, Masuyama N, Taya S, Kumai M, Minaki Y, Hamaguchi A, Inoue YU, Inoue T, Miyashita S, Fujiyama T, Yamada M, Chapman H, Campbell K, Magnuson MA, Wright CV, Kawaguchi Y, Ikenaka K, Takebayashi H, Ishiwata S, Ono Y, Hoshino M. Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum. Nat Commun. 2014; 5: 3337. PMID: 24535035, PII: ncomms4337, DOI: 10.1038/ncomms4337, ISSN: 2041-1723.

Worchel HN, Magnuson MA. Cytokine-driven beta-cell production in vivo. Nature biotechnology. 2014 Jan; 32(1) Sect. 63,4.

Magnuson MA, Osipovich AB. Pancreas-specific Cre driver lines and considerations for their prudent use. Cell Metab. 2013 Jul 7/2/2013; 18(1): 9-20. PMID: 23823474, PMCID: PMC3732107, PII: S1550-4131(13)00255-6, DOI: 10.1016/j.cmet.2013.06.011, ISSN: 1932-7420.

Pan FC, Bankaitis ED, Boyer D, Xu X, Van de Casteele M, Magnuson MA, Heimberg H, Wright CV. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development [print-electronic]. 2013 Feb; 140(4): 751-64. PMID: 23325761, PMCID: PMC3557774, PII: dev.090159, DOI: 10.1242/dev.090159, ISSN: 1477-9129.

Choi E, Kraus MR, Lemaire LA, Yoshimoto M, Vemula S, Potter LA, Manduchi E, Stoeckert CJ, Grapin-Botton A, Magnuson MA. Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells. 2012 Oct; 30(10): 2297-308. PMID: 22865702, PMCID: PMC3448801, DOI: 10.1002/stem.1192, ISSN: 1549-4918.

McKenna NJ, Howard CL, Aufiero M, Easton-Marks J, Steffen DL, Becnel LB, Magnuson MA, McIndoe RA, Cartailler JP. Research resource: dkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) consortium interconnectivity network: a pilot program to aggregate research resources generated by multiple research consortia. Mol. Endocrinol [print-electronic]. 2012 Oct; 26(10): 1675-81. PMID: 22734043, PMCID: PMC3458218, PII: me.2012-1077, DOI: 10.1210/me.2012-1077, ISSN: 1944-9917.

Potter LA, Choi E, Hipkens SB, Wright CV, Magnuson MA. A recombinase-mediated cassette exchange-derived cyan fluorescent protein reporter allele for Pdx1. Genesis [print-electronic]. 2012 Apr; 50(4): 384-92. PMID: 21913313, PMCID: PMC3870909, DOI: 10.1002/dvg.20804, ISSN: 1526-968X.

Petersen DR, Gustavsen C, Lindskog SR, Magnuson MA, Zaret KS, Serup P. Engineering artificial signaling centers to polarize embryoid body differentiation. Stem Cells Dev [print-electronic]. 2012 Mar 3/1/2012; 21(4): 647-53. PMID: 21958075, PMCID: PMC3280603, DOI: 10.1089/scd.2011.0344, ISSN: 1557-8534.

Kopinke D, Brailsford M, Pan FC, Magnuson MA, Wright CV, Murtaugh LC. Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev. Biol [print-electronic]. 2012 Feb 2/1/2012; 362(1): 57-64. PMID: 22146645, PMCID: PMC3254730, PII: S0012-1606(11)01392-3, DOI: 10.1016/j.ydbio.2011.11.010, ISSN: 1095-564X.

Plank JL, Frist AY, LeGrone AW, Magnuson MA, Labosky PA. Loss of Foxd3 results in decreased ß-cell proliferation and glucose intolerance during pregnancy. Endocrinology [print-electronic]. 2011 Dec; 152(12): 4589-600. PMID: 21952247, PMCID: PMC3230055, PII: en.2010-1462, DOI: 10.1210/en.2010-1462, ISSN: 1945-7170.

Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L. Nkx2.2 repressor complex regulates islet ß-cell specification and prevents ß-to-a-cell reprogramming. Genes Dev. 2011 Nov 11/1/2011; 25(21): 2291-305. PMID: 22056672, PMCID: PMC3219233, PII: 25/21/2291, DOI: 10.1101/gad.173039.111, ISSN: 1549-5477.

Watanabe H, Yang T, Stroud DM, Lowe JS, Harris L, Atack TC, Wang DW, Hipkens SB, Leake B, Hall L, Kupershmidt S, Chopra N, Magnuson MA, Tanabe N, Knollmann BC, George AL, Roden DM. Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation [print-electronic]. 2011 Aug 8/30/2011; 124(9): 1001-11. PMID: 21824921, PMCID: PMC3297976, PII: CIRCULATIONAHA.110.987248, DOI: 10.1161/CIRCULATIONAHA.110.987248, ISSN: 1524-4539.

Chen SX, Osipovich AB, Ustione A, Potter LA, Hipkens S, Gangula R, Yuan W, Piston DW, Magnuson MA. Quantification of factors influencing fluorescent protein expression using RMCE to generate an allelic series in the ROSA26 locus in mice. Dis Model Mech [print-electronic]. 2011 Jul; 4(4): 537-47. PMID: 21324933, PMCID: PMC3124063, PII: dmm.006569, DOI: 10.1242/dmm.006569, ISSN: 1754-8411.

Salpeter SJ, Klochendler A, Weinberg-Corem N, Porat S, Granot Z, Shapiro AM, Magnuson MA, Eden A, Grimsby J, Glaser B, Dor Y. Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic ß-cells through glycolysis and calcium channels. Endocrinology [print-electronic]. 2011 Jul; 152(7): 2589-98. PMID: 21521747, PMCID: PMC3115606, PII: en.2010-1372, DOI: 10.1210/en.2010-1372, ISSN: 1945-7170.

Atack TC, Stroud DM, Watanabe H, Yang T, Hall L, Hipkens SB, Lowe JS, Leake B, Magnuson MA, Yang P, Roden DM. Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel. Circ. Res [print-electronic]. 2011 Jun 6/24/2011; 109(1): 38-46. PMID: 21566215, PMCID: PMC3135383, PII: CIRCRESAHA.110.235630, DOI: 10.1161/CIRCRESAHA.110.235630, ISSN: 1524-4571.

Porat S, Weinberg-Corem N, Tornovsky-Babaey S, Schyr-Ben-Haroush R, Hija A, Stolovich-Rain M, Dadon D, Granot Z, Ben-Hur V, White P, Girard CA, Karni R, Kaestner KH, Ashcroft FM, Magnuson MA, Saada A, Grimsby J, Glaser B, Dor Y. Control of pancreatic ß cell regeneration by glucose metabolism. Cell Metab. 2011 Apr 4/6/2011; 13(4): 440-9. PMID: 21459328, PII: S1550-4131(11)00085-4, DOI: 10.1016/j.cmet.2011.02.012, ISSN: 1932-7420.

Gu Y, Lindner J, Kumar A, Yuan W, Magnuson MA. Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Diabetes [print-electronic]. 2011 Mar; 60(3): 827-37. PMID: 21266327, PMCID: PMC3046843, PII: db10-1194, DOI: 10.2337/db10-1194, ISSN: 1939-327X.

Artner I, Hang Y, Mazur M, Yamamoto T, Guo M, Lindner J, Magnuson MA, Stein R. MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes [print-electronic]. 2010 Oct; 59(10): 2530-9. PMID: 20627934, PMCID: PMC3279542, PII: db10-0190, DOI: 10.2337/db10-0190, ISSN: 1939-327X.

Masui T, Swift GH, Deering T, Shen C, Coats WS, Long Q, Elsässer HP, Magnuson MA, MacDonald RJ. Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells. Gastroenterology [print-electronic]. 2010 Jul; 139(1): 270-80. PMID: 20398665, PMCID: PMC2902682, PII: S0016-5085(10)00549-4, DOI: 10.1053/j.gastro.2010.04.003, ISSN: 1528-0012.

Lee K, Gudapati P, Dragovic S, Spencer C, Joyce S, Killeen N, Magnuson MA, Boothby M. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity. 2010 Jun 6/25/2010; 32(6): 743-53. PMID: 20620941, PMCID: PMC2911434, PII: S1074-7613(10)00205-0, DOI: 10.1016/j.immuni.2010.06.002, ISSN: 1097-4180.

Boulbes D, Chen CH, Shaikenov T, Agarwal NK, Peterson TR, Addona TA, Keshishian H, Carr SA, Magnuson MA, Sabatini DM, Sarbassov dos D. Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2. Mol. Cancer Res [print-electronic]. 2010 Jun; 8(6): 896-906. PMID: 20501647, PMCID: PMC2896829, PII: 1541-7786.MCR-09-0409, DOI: 10.1158/1541-7786.MCR-09-0409, ISSN: 1557-3125.

Kumar A, Lawrence JC, Jung DY, Ko HJ, Keller SR, Kim JK, Magnuson MA, Harris TE. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes [print-electronic]. 2010 Jun; 59(6): 1397-406. PMID: 20332342, PMCID: PMC2874700, PII: db09-1061, DOI: 10.2337/db09-1061, ISSN: 1939-327X.

Jiang M, Fernandez S, Jerome WG, He Y, Yu X, Cai H, Boone B, Yi Y, Magnuson MA, Roy-Burman P, Matusik RJ, Shappell SB, Hayward SW. Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy. Cell Death Differ [print-electronic]. 2010 Mar; 17(3): 469-81. PMID: 19834493, PMCID: PMC2821953, PII: cdd2009148, DOI: 10.1038/cdd.2009.148, ISSN: 1476-5403.

Treins C, Warne PH, Magnuson MA, Pende M, Downward J. Rictor is a novel target of p70 S6 kinase-1. Oncogene [print-electronic]. 2010 Feb 2/18/2010; 29(7): 1003-16. PMID: 19935711, PII: onc2009401, DOI: 10.1038/onc.2009.401, ISSN: 1476-5594.

Siuta MA, Robertson SD, Kocalis H, Saunders C, Gresch PJ, Khatri V, Shiota C, Kennedy JP, Lindsley CW, Daws LC, Polley DB, Veenstra-Vanderweele J, Stanwood GD, Magnuson MA, Niswender KD, Galli A. Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice. PLoS Biol. 2010; 8(6): e1000393. PMID: 20543991, PMCID: PMC2882427, DOI: 10.1371/journal.pbio.1000393, ISSN: 1545-7885.

Zhang H, Ables ET, Pope CF, Washington MK, Hipkens S, Means AL, Path G, Seufert J, Costa RH, Leiter AB, Magnuson MA, Gannon M. Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech. Dev [print-electronic]. 2009 Dec; 126(11-12): 958-73. PMID: 19766716, PMCID: PMC2783291, PII: S0925-4773(09)01453-1, DOI: 10.1016/j.mod.2009.09.006, ISSN: 1872-6356.

Berglund ED, Lee-Young RS, Lustig DG, Lynes SE, Donahue EP, Camacho RC, Meredith ME, Magnuson MA, Charron MJ, Wasserman DH. Hepatic energy state is regulated by glucagon receptor signaling in mice. J. Clin. Invest. 2009 Aug; 119(8): 2412-22. PMID: 19662685, PMCID: PMC2719934, ISSN: 1558-8238.

Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, Magnuson MA, Serup P, Gu G. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2009 Jun 6/16/2009; 106(24): 9715-20. PMID: 19487660, PMCID: PMC2701002, PII: 0904247106, DOI: 10.1073/pnas.0904247106, ISSN: 1091-6490.

Huppert SS, Magnuson MA. New complexity in differentiating stem cells toward hepatic and pancreatic fates. Sci Signal. 2009; 2(83): pe50. PMID: 19671927, PII: scisignal.283pe50, DOI: 10.1126/scisignal.283pe50, ISSN: 1937-9145.

Zelent B, Odili S, Buettger C, Shiota C, Grimsby J, Taub R, Magnuson MA, Vanderkooi JM, Matschinsky FM. Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence. Biochem. J. 2008 Jul 7/15/2008; 413(2): 269-80. PMID: 18370929, PII: BJ20071718, DOI: 10.1042/BJ20071718, ISSN: 1470-8728.

Hagan GN, Lin Y, Magnuson MA, Avruch J, Czech MP. A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol. Cell. Biol [print-electronic]. 2008 Jul; 28(13): 4215-26. PMID: 18426911, PMCID: PMC2447144, PII: MCB.00867-07, DOI: 10.1128/MCB.00867-07, ISSN: 1098-5549.

Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA. Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev. Biol [print-electronic]. 2008 Apr 4/1/2008; 316(1): 74-86. PMID: 18294628, PMCID: PMC2425677, PII: S0012-1606(08)00034-1, DOI: 10.1016/j.ydbio.2008.01.011, ISSN: 1095-564X.

Elrod JW, Harrell M, Flagg TP, Gundewar S, Magnuson MA, Nichols CG, Coetzee WA, Lefer DJ. Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury. Circulation [print-electronic]. 2008 Mar 3/18/2008; 117(11): 1405-13. PMID: 18316485, PII: CIRCULATIONAHA.107.745539, DOI: 10.1161/CIRCULATIONAHA.107.745539, ISSN: 1524-4539.

Shiota M, Magnuson MA. Hepatic glucose sensing: does flux matter?. J. Clin. Invest. 2008 Mar; 118(3): 841-4. PMID: 18292804, PMCID: PMC2248806, DOI: 10.1172/JCI35137, ISSN: 0021-9738.

Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV. Pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev. Biol [print-electronic]. 2008 Feb 2/15/2008; 314(2): 406-17. PMID: 18155690, PMCID: PMC2269701, PII: S0012-1606(07)01464-9, DOI: 10.1016/j.ydbio.2007.10.038, ISSN: 1095-564X.

Hori K, Cholewa-Waclaw J, Nakada Y, Glasgow SM, Masui T, Henke RM, Wildner H, Martarelli B, Beres TM, Epstein JA, Magnuson MA, Macdonald RJ, Birchmeier C, Johnson JE. A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes Dev. 2008 Jan 1/15/2008; 22(2): 166-78. PMID: 18198335, PMCID: PMC2192752, PII: 22/2/166, DOI: 10.1101/gad.1628008, ISSN: 0890-9369.

Kumar A, Harris TE, Keller SR, Choi KM, Magnuson MA, Lawrence JC. Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity. Mol. Cell. Biol [print-electronic]. 2008 Jan; 28(1): 61-70. PMID: 17967879, PMCID: PMC2223287, PII: MCB.01405-07, DOI: 10.1128/MCB.01405-07, ISSN: 1098-5549.

Wang S, Zhang J, Zhao A, Hipkens S, Magnuson MA, Gu G. Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech. Dev [print-electronic]. 2007 Nov; 124(11-12): 898-910. PMID: 17928203, PMCID: PMC2141686, PII: S0925-4773(07)00147-5, DOI: 10.1016/j.mod.2007.08.004, ISSN: 0925-4773.

Magnuson MA, Burlison JS. Caveats and considerations for performing pancreas-specific gene manipulations in the mouse. Diabetes Obes Metab. 2007 Nov; 9 Suppl 2: 5-13. PMID: 17919173, PII: DOM771, DOI: 10.1111/j.1463-1326.2007.00771.x, ISSN: 1462-8902.

Masui T, Long Q, Beres TM, Magnuson MA, MacDonald RJ. Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes Dev. 2007 Oct 10/15/2007; 21(20): 2629-43. PMID: 17938243, PMCID: PMC2000326, PII: 21/20/2629, DOI: 10.1101/gad.1575207, ISSN: 0890-9369.

Niswender KD, Magnuson MA. Obesity and the beta cell: lessons from leptin. J. Clin. Invest. 2007 Oct; 117(10): 2753-6. PMID: 17909621, PMCID: PMC1994637, DOI: 10.1172/JCI33528, ISSN: 0021-9738.

Pearce LR, Huang X, Boudeau J, Pawlowski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA, Alessi DR. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem. J. 2007 Aug 8/1/2007; 405(3): 513-22. PMID: 17461779, PMCID: PMC2267312, PII: BJ20070540, DOI: 10.1042/BJ20070540, ISSN: 1470-8728.

Yoshida K, Murao K, Imachi H, Cao WM, Yu X, Li J, Ahmed RA, Kitanaka N, Wong NC, Unterman TG, Magnuson MA, Ishida T. Pancreatic glucokinase is activated by insulin-like growth factor-I. Endocrinology [print-electronic]. 2007 Jun; 148(6): 2904-13. PMID: 17317782, PII: en.2006-1149, DOI: 10.1210/en.2006-1149, ISSN: 0013-7227.

Pino MF, Kim KA, Shelton KD, Lindner J, Odili S, Li C, Collins HW, Shiota M, Matschinsky FM, Magnuson MA. Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations. J. Biol. Chem [print-electronic]. 2007 May 5/4/2007; 282(18): 13906-16. PMID: 17353190, PII: M610094200, DOI: 10.1074/jbc.M610094200, ISSN: 0021-9258.

Oottamasathien S, Wang Y, Williams K, Franco OE, Wills ML, Thomas JC, Saba K, Sharif-Afshar AR, Makari JH, Bhowmick NA, DeMarco RT, Hipkens S, Magnuson M, Brock JW, Hayward SW, Pope JC, Matusik RJ. Directed differentiation of embryonic stem cells into bladder tissue. Dev. Biol [print-electronic]. 2007 Apr 4/15/2007; 304(2): 556-66. PMID: 17289017, PMCID: PMC1994155, PII: S0012-1606(07)00027-9, DOI: 10.1016/j.ydbio.2007.01.010, ISSN: 0012-1606.

Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA. Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab. 2007 Apr; 5(4): 313-20. PMID: 17403375, PMCID: PMC2680089, PII: S1550-4131(07)00065-4, DOI: 10.1016/j.cmet.2007.03.004, ISSN: 1550-4131.

Liu K, Hipkens S, Yang T, Abraham R, Zhang W, Chopra N, Knollmann B, Magnuson MA, Roden DM. Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels. Genesis. 2006 Nov; 44(11): 556-64. PMID: 17083109, DOI: 10.1002/dvg.20247, ISSN: 1526-954X.

Fujitani Y, Fujitani S, Luo H, Qiu F, Burlison J, Long Q, Kawaguchi Y, Edlund H, MacDonald RJ, Furukawa T, Fujikado T, Magnuson MA, Xiang M, Wright CV. Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development. 2006 Nov; 133(22): 4439-50. PMID: 17075007, PII: 133/22/4439, DOI: 10.1242/dev.02598, ISSN: 0950-1991.

Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev. Cell [print-electronic]. 2006 Oct; 11(4): 583-9. PMID: 16962829, PII: S1534-5807(06)00393-5, DOI: 10.1016/j.devcel.2006.08.013, ISSN: 1534-5807.

Doliba NM, Qin W, Vatamaniuk MZ, Buettger CW, Collins HW, Magnuson MA, Kaestner KH, Wilson DF, Carr RD, Matschinsky FM. Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2006 Sep; 291(3): E525-35. PMID: 16638820, PII: 00579.2005, DOI: 10.1152/ajpendo.00579.2005, ISSN: 0193-1849.

Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H. Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol. Cell. Biol. 2006 Apr; 26(7): 2772-81. PMID: 16537919, PMCID: PMC1430339, PII: 26/7/2772, DOI: 10.1128/MCB.26.7.2772-2781.2006, ISSN: 0270-7306.

Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I. Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells. J. Biol. Chem [print-electronic]. 2006 Feb 2/24/2006; 281(8): 5246-57. PMID: 16377800, PII: M507496200, DOI: 10.1074/jbc.M507496200, ISSN: 0021-9258.

Lee JY, Ristow M, Lin X, White MF, Magnuson MA, Hennighausen L. RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J. Biol. Chem [print-electronic]. 2006 Feb 2/3/2006; 281(5): 2649-53. PMID: 16326700, PII: M512373200, DOI: 10.1074/jbc.M512373200, ISSN: 0021-9258.

Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA, Wright CV. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev. 2006 Jan 1/15/2006; 20(2): 253-66. PMID: 16418487, PMCID: PMC1356115, PII: 20/2/253, DOI: 10.1101/gad.1360106, ISSN: 0890-9369.

Matschinsky FM, Magnuson MA, Zelent D, Jetton TL, Doliba N, Han Y, Taub R, Grimsby J. The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes. 2006 Jan; 55(1): 1-12. PMID: 16380470, PII: 55/1/1, ISSN: 0012-1797.

Thierbach R, Schulz TJ, Isken F, Voigt A, Mietzner B, Drewes G, von Kleist-Retzow JC, Wiesner RJ, Magnuson MA, Puccio H, Pfeiffer AF, Steinberg P, Ristow M. Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum. Mol. Genet [print-electronic]. 2005 Dec 12/15/2005; 14(24): 3857-64. PMID: 16278235, PII: ddi410, DOI: 10.1093/hmg/ddi410, ISSN: 0964-6906.

Shiota C, Rocheleau JV, Shiota M, Piston DW, Magnuson MA. Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2005 Oct; 289(4): E570-7. PMID: 15941784, PII: 00102.2005, DOI: 10.1152/ajpendo.00102.2005, ISSN: 0193-1849.

Park SY, Wang X, Chen Z, Powers AC, Magnuson MA, Head WS, Piston DW, Bell GI. Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene. Genesis. 2005 Oct; 43(2): 80-6. PMID: 16108006, DOI: 10.1002/gene.20157, ISSN: 1526-954X.

Guan Y, Hao C, Cha DR, Rao R, Lu W, Kohan DE, Magnuson MA, Redha R, Zhang Y, Breyer MD. Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat. Med [print-electronic]. 2005 Aug; 11(8): 861-6. PMID: 16007095, PII: nm1278, DOI: 10.1038/nm1278, ISSN: 1078-8956.

Babaev VR, Yancey PG, Ryzhov SV, Kon V, Breyer MD, Magnuson MA, Fazio S, Linton MF. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2005 Aug; 25(8): 1647-53. PMID: 15947238, PII: 01.ATV.0000173413.31789.1a, DOI: 10.1161/01.ATV.0000173413.31789.1a, ISSN: 1524-4636.

Roccisana J, Reddy V, Vasavada RC, Gonzalez-Pertusa JA, Magnuson MA, Garcia-Ocaña A. Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass. Diabetes. 2005 Jul; 54(7): 2090-102. PMID: 15983210, PII: 54/7/2090, ISSN: 0012-1797.

Wang CZ, Wang Y, Di A, Magnuson MA, Ye H, Roe MW, Nelson DJ, Bell GI, Philipson LH. 5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways. Biochem. Biophys. Res. Commun. 2005 May 5/20/2005; 330(4): 1073-9. PMID: 15823553, PII: S0006-291X(05)00599-1, DOI: 10.1016/j.bbrc.2005.03.093, ISSN: 0006-291X.

Schonhoff S, Baggio L, Ratineau C, Ray SK, Lindner J, Magnuson MA, Drucker DJ, Leiter AB. Energy homeostasis and gastrointestinal endocrine differentiation do not require the anorectic hormone peptide YY. Mol. Cell. Biol. 2005 May; 25(10): 4189-99. PMID: 15870288, PMCID: PMC1087718, PII: 25/10/4189, DOI: 10.1128/MCB.25.10.4189-4199.2005, ISSN: 0270-7306.

Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, Shiota M, Kesterson RA, Kahn BB, Magnuson MA. Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2005 Apr 4/26/2005; 102(17): 6207-12. PMID: 15833818, PMCID: PMC556131, PII: 0306743102, DOI: 10.1073/pnas.0306743102, ISSN: 0027-8424.

Romero-Gallo J, Sozmen EG, Chytil A, Russell WE, Whitehead R, Parks WT, Holdren MS, Her MF, Gautam S, Magnuson M, Moses HL, Grady WM. Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy. Oncogene. 2005 Apr 4/21/2005; 24(18): 3028-41. PMID: 15735717, PII: 1208475, DOI: 10.1038/sj.onc.1208475, ISSN: 0950-9232.

Gloyn AL, Odili S, Zelent D, Buettger C, Castleden HA, Steele AM, Stride A, Shiota C, Magnuson MA, Lorini R, d'Annunzio G, Stanley CA, Kwagh J, van Schaftingen E, Veiga-da-Cunha M, Barbetti F, Dunten P, Han Y, Grimsby J, Taub R, Ellard S, Hattersley AT, Matschinsky FM. Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young. J. Biol. Chem [print-electronic]. 2005 Apr 4/8/2005; 280(14): 14105-13. PMID: 15677479, PII: M413146200, DOI: 10.1074/jbc.M413146200, ISSN: 0021-9258.

Gunawardana SC, Hara M, Bell GI, Head WS, Magnuson MA, Piston DW. Imaging Beta cell development in real-time using pancreatic explants from mice with green fluorescent protein-labeled pancreatic Beta cells. In Vitro Cell. Dev. Biol. Anim. 2005 Jan; 41(1-2): 7-11. PMID: 15926862, PII: 0412080, DOI: 10.1290/0412080.1, ISSN: 1071-2690.

Jones JR, Shelton KD, Magnuson MA. Strategies for the use of site-specific recombinases in genome engineering. Methods Mol. Med. 2005; 103: 245-57. PMID: 15542911, PII: 1-59259-780-7:245, ISSN: 1543-1894.

Burgess SC, Hausler N, Merritt M, Jeffrey FM, Storey C, Milde A, Koshy S, Lindner J, Magnuson MA, Malloy CR, Sherry AD. Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J. Biol. Chem [print-electronic]. 2004 Nov 11/19/2004; 279(47): 48941-9. PMID: 15347677, PII: M407120200, DOI: 10.1074/jbc.M407120200, ISSN: 0021-9258.

Moates JM, Magnuson MA. The Pal elements in the upstream glucokinase promoter exhibit dyad symmetry and display cell-specific enhancer activity when multimerised. Diabetologia [print-electronic]. 2004 Sep; 47(9): 1632-40. PMID: 15365616, DOI: 10.1007/s00125-004-1497-1, ISSN: 0012-186X.

Schneider A, Guan Y, Zhang Y, Magnuson MA, Pettepher C, Loftin CD, Langenbach R, Breyer RM, Breyer MD. Generation of a conditional allele of the mouse prostaglandin EP4 receptor. Genesis. 2004 Sep; 40(1): 7-14. PMID: 15354288, DOI: 10.1002/gene.20048, ISSN: 1526-954X.

Long Q, Shelton KD, Lindner J, Jones JR, Magnuson MA. Efficient DNA cassette exchange in mouse embryonic stem cells by staggered positive-negative selection. Genesis. 2004 Aug; 39(4): 256-62. PMID: 15286998, DOI: 10.1002/gene.20053, ISSN: 1526-954X.

Gorogawa S, Fujitani Y, Kaneto H, Hazama Y, Watada H, Miyamoto Y, Takeda K, Akira S, Magnuson MA, Yamasaki Y, Kajimoto Y, Hori M. Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochem. Biophys. Res. Commun. 2004 Jul 7/9/2004; 319(4): 1159-70. PMID: 15194489, PII: S0006291X04010691, DOI: 10.1016/j.bbrc.2004.05.095, ISSN: 0006-291X.

Dentin R, Pégorier JP, Benhamed F, Foufelle F, Ferré P, Fauveau V, Magnuson MA, Girard J, Postic C. Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J. Biol. Chem [print-electronic]. 2004 May 5/7/2004; 279(19): 20314-26. PMID: 14985368, PII: M312475200, DOI: 10.1074/jbc.M312475200, ISSN: 0021-9258.

Doliba NM, Qin W, Vatamaniuk MZ, Li C, Zelent D, Najafi H, Buettger CW, Collins HW, Carr RD, Magnuson MA, Matschinsky FM. Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 May; 286(5): E834-43. PMID: 14736703, PII: 00292.2003, DOI: 10.1152/ajpendo.00292.2003, ISSN: 0193-1849.

Chu CA, Fujimoto Y, Igawa K, Grimsby J, Grippo JF, Magnuson MA, Cherrington AD, Shiota M. Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2004 Apr; 286(4): G627-34. PMID: 14656711, PII: 00218.2003, DOI: 10.1152/ajpgi.00218.2003, ISSN: 0193-1857.

Biondi CA, Gartside MG, Waring P, Loffler KA, Stark MS, Magnuson MA, Kay GF, Hayward NK. Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Mol. Cell. Biol. 2004 Apr; 24(8): 3125-31. PMID: 15060136, PMCID: PMC381682, ISSN: 0270-7306.

Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2004 Feb 2/17/2004; 101(7): 2082-7. PMID: 14769918, PMCID: PMC357055, PII: 0308617100, DOI: 10.1073/pnas.0308617100, ISSN: 0027-8424.

Miyatsuka T, Kaneto H, Kajimoto Y, Hirota S, Arakawa Y, Fujitani Y, Umayahara Y, Watada H, Yamasaki Y, Magnuson MA, Miyazaki J, Hori M. Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem. Biophys. Res. Commun. 2003 Oct 10/24/2003; 310(3): 1017-25. PMID: 14550306, PII: S0006291X03018874, ISSN: 0006-291X.

Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH, Eisenman D, Magnuson MA, Gonzalez FJ, Kahn CR, Spiegelman BM. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol. Cell. Biol. 2003 Oct; 23(20): 7222-9. PMID: 14517292, PMCID: PMC230305, ISSN: 0270-7306.

Gloyn AL, Noordam K, Willemsen MA, Ellard S, Lam WW, Campbell IW, Midgley P, Shiota C, Buettger C, Magnuson MA, Matschinsky FM, Hattersley AT. Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations. Diabetes. 2003 Sep; 52(9): 2433-40. PMID: 12941786, ISSN: 0012-1797.

Crabtree JS, Scacheri PC, Ward JM, McNally SR, Swain GP, Montagna C, Hager JH, Hanahan D, Edlund H, Magnuson MA, Garrett-Beal L, Burns AL, Ried T, Chandrasekharappa SC, Marx SJ, Spiegel AM, Collins FS. Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol. Cell. Biol. 2003 Sep; 23(17): 6075-85. PMID: 12917331, PMCID: PMC180910, ISSN: 0270-7306.

Magnuson MA, She P, Shiota M. Gene-altered mice and metabolic flux control. J. Biol. Chem [print-electronic]. 2003 Aug 8/29/2003; 278(35): 32485-8. PMID: 12788933, PII: R300020200, DOI: 10.1074/jbc.R300020200, ISSN: 0021-9258.

Martín J, Hunt SL, Dubus P, Sotillo R, Néhmé-Pélluard F, Magnuson MA, Parlow AF, Malumbres M, Ortega S, Barbacid M. Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene. 2003 Aug 8/14/2003; 22(34): 5261-9. PMID: 12917627, PII: 1206506, DOI: 10.1038/sj.onc.1206506, ISSN: 0950-9232.

Ristow M, Mulder H, Pomplun D, Schulz TJ, Müller-Schmehl K, Krause A, Fex M, Puccio H, Müller J, Isken F, Spranger J, Müller-Wieland D, Magnuson MA, Möhlig M, Koenig M, Pfeiffer AF. Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass. J. Clin. Invest. 2003 Aug; 112(4): 527-34. PMID: 12925693, PMCID: PMC171391, PII: 112/4/527, DOI: 10.1172/JCI18107, ISSN: 0021-9738.

Schulla V, Renström E, Feil R, Feil S, Franklin I, Gjinovci A, Jing XJ, Laux D, Lundquist I, Magnuson MA, Obermüller S, Olofsson CS, Salehi A, Wendt A, Klugbauer N, Wollheim CB, Rorsman P, Hofmann F. Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. EMBO J. 2003 Aug 8/1/2003; 22(15): 3844-54. PMID: 12881419, PMCID: PMC169062, DOI: 10.1093/emboj/cdg389, ISSN: 0261-4189.

Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF. Allosteric activators of glucokinase: potential role in diabetes therapy. Science. 2003 Jul 7/18/2003; 301(5631): 370-3. PMID: 12869762, PII: 301/5631/370, DOI: 10.1126/science.1084073, ISSN: 1095-9203.

She P, Burgess SC, Shiota M, Flakoll P, Donahue EP, Malloy CR, Sherry AD, Magnuson MA. Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation. Diabetes. 2003 Jul; 52(7): 1649-54. PMID: 12829628, ISSN: 0012-1797.

Henderson CJ, Otto DM, Carrie D, Magnuson MA, McLaren AW, Rosewell I, Wolf CR. Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J. Biol. Chem [print-electronic]. 2003 Apr 4/11/2003; 278(15): 13480-6. PMID: 12566435, PII: M212087200, DOI: 10.1074/jbc.M212087200, ISSN: 0021-9258.

Lee YH, Magnuson MA, Muppala V, Chen SS. Liver-specific reactivation of the inactivated Hnf-1alpha gene: elimination of liver dysfunction to establish a mouse MODY3 model. Mol. Cell. Biol. 2003 Feb; 23(3): 923-32. PMID: 12529398, PMCID: PMC140695, ISSN: 0270-7306.

Hara M, Wang X, Kawamura T, Bindokas VP, Dizon RF, Alcoser SY, Magnuson MA, Bell GI. Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2003 Jan; 284(1): E177-83. PMID: 12388130, PII: 00321.2002, DOI: 10.1152/ajpendo.00321.2002, ISSN: 0193-1849.

Shiota C, Larsson O, Shelton KD, Shiota M, Efanov AM, Hoy M, Lindner J, Kooptiwut S, Juntti-Berggren L, Gromada J, Berggren PO, Magnuson MA. Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J. Biol. Chem [print-electronic]. 2002 Oct 10/4/2002; 277(40): 37176-83. PMID: 12149271, PII: M206757200, DOI: 10.1074/jbc.M206757200, ISSN: 0021-9258.

Rizzo MA, Magnuson MA, Drain PF, Piston DW. A functional link between glucokinase binding to insulin granules and conformational alterations in response to glucose and insulin. J. Biol. Chem [print-electronic]. 2002 Sep 9/13/2002; 277(37): 34168-75. PMID: 12101177, PII: M112478200, DOI: 10.1074/jbc.M112478200, ISSN: 0021-9258.

Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, Magnuson MA, Kahn CR. Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat. Genet [print-electronic]. 2002 May; 31(1): 111-5. PMID: 11923875, PII: ng872, DOI: 10.1038/ng872, ISSN: 1061-4036.

Christesen HB, Jacobsen BB, Odili S, Buettger C, Cuesta-Munoz A, Hansen T, Brusgaard K, Massa O, Magnuson MA, Shiota C, Matschinsky FM, Barbetti F. The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy. Diabetes. 2002 Apr; 51(4): 1240-6. PMID: 11916951, ISSN: 0012-1797.

Xin HB, Senbonmatsu T, Cheng DS, Wang YX, Copello JA, Ji GJ, Collier ML, Deng KY, Jeyakumar LH, Magnuson MA, Inagami T, Kotlikoff MI, Fleischer S. Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature. 2002 Mar 3/21/2002; 416(6878): 334-8. PMID: 11907581, PII: 416334a, DOI: 10.1038/416334a, ISSN: 0028-0836.

Jones JR, Shelton KD, Guan Y, Breyer MD, Magnuson MA. Generation and functional confirmation of a conditional null PPARgamma allele in mice. Genesis. 2002 Feb; 32(2): 134-7. PMID: 11857800, PII: 10.1002/gene.10042, ISSN: 1526-954X.

Chytil A, Magnuson MA, Wright CV, Moses HL. Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis. 2002 Feb; 32(2): 73-5. PMID: 11857781, PII: 10.1002/gene.10046, ISSN: 1526-954X.

Sund NJ, Vatamaniuk MZ, Casey M, Ang SL, Magnuson MA, Stoffers DA, Matschinsky FM, Kaestner KH. Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Genes Dev. 2001 Jul 7/1/2001; 15(13): 1706-15. PMID: 11445544, PMCID: PMC312732, DOI: 10.1101/gad.901601, ISSN: 0890-9369.

Efanov AM, Høy M, Bränström R, Zaitsev SV, Magnuson MA, Efendic S, Gromada J, Berggren PO. The imidazoline RX871024 stimulates insulin secretion in pancreatic beta-cells from mice deficient in K(ATP) channel function. Biochem. Biophys. Res. Commun. 2001 Jun 6/22/2001; 284(4): 918-22. PMID: 11409880, PII: S0006-291X(01)95068-5, DOI: 10.1006/bbrc.2001.5068, ISSN: 0006-291X.

Njølstad PR, Søvik O, Cuesta-Muñoz A, Bjørkhaug L, Massa O, Barbetti F, Undlien DE, Shiota C, Magnuson MA, Molven A, Matschinsky FM, Bell GI. Neonatal diabetes mellitus due to complete glucokinase deficiency. N. Engl. J. Med. 2001 May 5/24/2001; 344(21): 1588-92. PMID: 11372010, DOI: 10.1056/NEJM200105243442104, ISSN: 0028-4793.

Holla VR, Adas F, Imig JD, Zhao X, Price E, Olsen N, Kovacs WJ, Magnuson MA, Keeney DS, Breyer MD, Falck JR, Waterman MR, Capdevila JH. Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc. Natl. Acad. Sci. U.S.A. 2001 Apr 4/24/2001; 98(9): 5211-6. PMID: 11320253, PMCID: PMC33189, PII: 98/9/5211, DOI: 10.1073/pnas.081627898, ISSN: 0027-8424.

Shiota M, Postic C, Fujimoto Y, Jetton TL, Dixon K, Pan D, Grimsby J, Grippo JF, Magnuson MA, Cherrington AD. Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes. Diabetes. 2001 Mar; 50(3): 622-9. PMID: 11246883, ISSN: 0012-1797.

Sakai T, Johnson KJ, Murozono M, Sakai K, Magnuson MA, Wieloch T, Cronberg T, Isshiki A, Erickson HP, Fässler R. Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. Nat. Med. 2001 Mar; 7(3): 324-30. PMID: 11231631, PII: 85471, DOI: 10.1038/85471, ISSN: 1078-8956.

Jetton TL, Shiota M, Knobel SM, Piston DW, Cherrington AD, Magnuson MA. Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition. Int. J. Exp. Diabetes Res. 2001; 2(3): 173-86. PMID: 12369705, PMCID: PMC2478546, ISSN: 1560-4284.

Postic C, Shiota M, Magnuson MA. Cell-specific roles of glucokinase in glucose homeostasis. Recent Prog. Horm. Res. 2001; 56: 195-217. PMID: 11237213, ISSN: 0079-9963.

Silva JP, Köhler M, Graff C, Oldfors A, Magnuson MA, Berggren PO, Larsson NG. Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes. Nat. Genet. 2000 Nov; 26(3): 336-40. PMID: 11062475, DOI: 10.1038/81649, ISSN: 1061-4036.

She P, Shiota M, Shelton KD, Chalkley R, Postic C, Magnuson MA. Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol. Cell. Biol. 2000 Sep; 20(17): 6508-17. PMID: 10938127, PMCID: PMC86125, ISSN: 0270-7306.

Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn CR. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell. 2000 Jul; 6(1): 87-97. PMID: 10949030, PII: S1097-2765(05)00015-8, ISSN: 1097-2765.

Sund NJ, Ang SL, Sackett SD, Shen W, Daigle N, Magnuson MA, Kaestner KH. Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol. Cell. Biol. 2000 Jul; 20(14): 5175-83. PMID: 10866673, PMCID: PMC85966, ISSN: 0270-7306.

Wan YJ, An D, Cai Y, Repa JJ, Hung-Po Chen T, Flores M, Postic C, Magnuson MA, Chen J, Chien KR, French S, Mangelsdorf DJ, Sucov HM. Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver. Mol. Cell. Biol. 2000 Jun; 20(12): 4436-44. PMID: 10825207, PMCID: PMC85811, ISSN: 0270-7306.

Grimsby J, Coffey JW, Dvorozniak MT, Magram J, Li G, Matschinsky FM, Shiota C, Kaur S, Magnuson MA, Grippo JF. Characterization of glucokinase regulatory protein-deficient mice. J. Biol. Chem. 2000 Mar 3/17/2000; 275(11): 7826-31. PMID: 10713097, ISSN: 0021-9258.

Postic C, Magnuson MA. DNA excision in liver by an albumin-Cre transgene occurs progressively with age. Genesis. 2000 Feb; 26(2): 149-50. PMID: 10686614, PII: 10.1002/(SICI)1526-968X(200002)26:2<149::AID-GENE16>3.0.CO;2-V, ISSN: 1526-954X.

Gannon M, Shiota C, Postic C, Wright CV, Magnuson M. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis. 2000 Feb; 26(2): 139-42. PMID: 10686610, PII: 10.1002/(SICI)1526-968X(200002)26:2<139::AID-GENE12>3.0.CO;2-7, ISSN: 1526-954X.

Shiota C, Coffey J, Grimsby J, Grippo JF, Magnuson MA. Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase. J. Biol. Chem. 1999 Dec 12/24/1999; 274(52): 37125-30. PMID: 10601273, ISSN: 0021-9258.

Davis EA, Cuesta-Muñoz A, Raoul M, Buettger C, Sweet I, Moates M, Magnuson MA, Matschinsky FM. Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis. Diabetologia. 1999 Oct; 42(10): 1175-86. PMID: 10525657, PII: 90421175.125, DOI: 10.1007/s001250051289, ISSN: 0012-186X.

Lu JT, Son YJ, Lee J, Jetton TL, Shiota M, Moscoso L, Niswender KD, Loewy AD, Magnuson MA, Sanes JR, Emeson RB. Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development. Mol. Cell. Neurosci. 1999 Aug; 14(2): 99-120. PMID: 10532808, PII: S1044-7431(99)90767-4, DOI: 10.1006/mcne.1999.0767, ISSN: 1044-7431.

Williams CP, Postic C, Robin D, Robin P, Parrinello J, Shelton K, Printz RL, Magnuson MA, Granner DK, Forest C, Chalkley R. Isolation and characterization of the mouse cytosolic phosphoenolpyruvate carboxykinase (GTP) gene: evidence for tissue-specific hypersensitive sites. Mol. Cell. Endocrinol. 1999 Feb 2/25/1999; 148(1-2): 67-77. PMID: 10221772, PII: S0303-7207(98)00234-2, ISSN: 0303-7207.

Kupershmidt S, Yang T, Anderson ME, Wessels A, Niswender KD, Magnuson MA, Roden DM. Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. Circ. Res. 1999 Feb 2/5/1999; 84(2): 146-52. PMID: 9933245, ISSN: 0009-7330.

Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell. 1999 Feb 2/5/1999; 96(3): 329-39. PMID: 10025399, PII: S0092-8674(00)80546-2, ISSN: 0092-8674.

Kennedy CR, Zhang Y, Brandon S, Guan Y, Coffee K, Funk CD, Magnuson MA, Oates JA, Breyer MD, Breyer RM. Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor. Nat. Med. 1999 Feb; 5(2): 217-20. PMID: 9930871, DOI: 10.1038/5583, ISSN: 1078-8956.

Piston DW, Knobel SM, Postic C, Shelton KD, Magnuson MA. Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion. J. Biol. Chem. 1999 Jan 1/8/1999; 274(2): 1000-4. PMID: 9873043, ISSN: 0021-9258.

Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J. Biol. Chem. 1999 Jan 1/1/1999; 274(1): 305-15. PMID: 9867845, ISSN: 0021-9258.

Postic C, Magnuson MA. [Role of glucokinase (GK) in the maintenance of glucose homeostasis. Specific disruption of the gene by the Cre-loxP technique]. Journ Annu Diabetol Hotel Dieu. 1999; 115-24. PMID: 10732411, ISSN: 0075-4439.

Weaver CD, Partridge JG, Yao TL, Moates JM, Magnuson MA, Verdoorn TA. Activation of glycine and glutamate receptors increases intracellular calcium in cells derived from the endocrine pancreas. Mol. Pharmacol. 1998 Oct; 54(4): 639-46. PMID: 9765506, ISSN: 0026-895X.

Jetton TL, Moates JM, Lindner J, Wright CV, Magnuson MA. Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells. Proc. Natl. Acad. Sci. U.S.A. 1998 Jul 7/21/1998; 95(15): 8654-9. PMID: 9671733, PMCID: PMC21131, ISSN: 0027-8424.

Castillo SO, Baffi JS, Palkovits M, Goldstein DS, Kopin IJ, Witta J, Magnuson MA, Nikodem VM. Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene. Mol. Cell. Neurosci. 1998 May; 11(1-2): 36-46. PMID: 9608532, PII: S1044-7431(98)90673-X, DOI: 10.1006/mcne.1998.0673, ISSN: 1044-7431.

Matschinsky FM, Glaser B, Magnuson MA. Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities. Diabetes. 1998 Mar; 47(3): 307-15. PMID: 9519733, ISSN: 0012-1797.

Qu S, Niswender KD, Ji Q, van der Meer R, Keeney D, Magnuson MA, Wisdom R. Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development. 1997 Oct; 124(20): 3999-4008. PMID: 9374397, ISSN: 0950-1991.

Moates JM, Postic C, Decaux JF, Girard J, Magnuson MA. Variable expression of hepatic glucokinase in mice is due to a regulational locus that cosegregates with the glucokinase gene. Genomics. 1997 Oct 10/1/1997; 45(1): 185-93. PMID: 9339375, PII: S0888-7543(97)94936-3, DOI: 10.1006/geno.1997.4936, ISSN: 0888-7543.

Niswender KD, Shiota M, Postic C, Cherrington AD, Magnuson MA. Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. J. Biol. Chem. 1997 Sep 9/5/1997; 272(36): 22570-5. PMID: 9278411, ISSN: 0021-9258.

Niswender KD, Postic C, Jetton TL, Bennett BD, Piston DW, Efrat S, Magnuson MA. Cell-specific expression and regulation of a glucokinase gene locus transgene. J. Biol. Chem. 1997 Sep 9/5/1997; 272(36): 22564-9. PMID: 9278410, ISSN: 0021-9258.

Ji QS, Winnier GE, Niswender KD, Horstman D, Wisdom R, Magnuson MA, Carpenter G. Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. Proc. Natl. Acad. Sci. U.S.A. 1997 Apr 4/1/1997; 94(7): 2999-3003. PMID: 9096335, PMCID: PMC20311, ISSN: 0027-8424.

Kesavan P, Wang L, Davis E, Cuesta A, Sweet I, Niswender K, Magnuson MA, Matschinsky FM. Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2). Biochem. J. 1997 Feb 2/15/1997; 322 ( Pt 1): 57-63. PMID: 9078243, PMCID: PMC1218158, ISSN: 0264-6021.

Niswender KD, Postic C, Shiota M, Jetton TL, Magnuson MA. Effects of altered glucokinase gene copy number on blood glucose homoeostasis. Biochem. Soc. Trans. 1997 Feb; 25(1): 113-7. PMID: 9056854, ISSN: 0300-5127.

Wang R, Macmillan LB, Fremeau RT, Magnuson MA, Lindner J, Limbird LE. Expression of alpha 2-adrenergic receptor subtypes in the mouse brain: evaluation of spatial and temporal information imparted by 3 kb of 5' regulatory sequence for the alpha 2A AR-receptor gene in transgenic animals. Neuroscience. 1996 Sep; 74(1): 199-218. PMID: 8843087, PII: 0306452296001169, ISSN: 0306-4522.

Moates JM, Shelton KD, Magnuson MA. Characterization of the Pal motifs in the upstream glucokinase promoter: binding of a cell type-specific protein complex correlates with transcriptional activation. Mol. Endocrinol. 1996 Jun; 10(6): 723-31. PMID: 8776732, DOI: 10.1210/mend.10.6.8776732, ISSN: 0888-8809.

Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 1996 Mar; 122(3): 983-95. PMID: 8631275, ISSN: 0950-1991.

Bennett BD, Jetton TL, Ying G, Magnuson MA, Piston DW. Quantitative subcellular imaging of glucose metabolism within intact pancreatic islets. J. Biol. Chem. 1996 Feb 2/16/1996; 271(7): 3647-51. PMID: 8631975, ISSN: 0021-9258.

Parsa R, Decaux JF, Bossard P, Robey BR, Magnuson MA, Granner DK, Girard J. Induction of the glucokinase gene by insulin in cultured neonatal rat hepatocytes. Relationship with DNase-I hypersensitive sites and functional analysis of a putative insulin-response element. Eur. J. Biochem. 1996 Feb 2/15/1996; 236(1): 214-21. PMID: 8617267, ISSN: 0014-2956.

Niswender KD, Blackman SM, Rohde L, Magnuson MA, Piston DW. Quantitative imaging of green fluorescent protein in cultured cells: comparison of microscopic techniques, use in fusion proteins and detection limits. J Microsc. 1995 Nov; 180(Pt 2): 109-16. PMID: 8537958, ISSN: 0022-2720.

Postic C, Niswender KD, Decaux JF, Parsa R, Shelton KD, Gouhot B, Pettepher CC, Granner DK, Girard J, Magnuson MA. Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites. Genomics. 1995 Oct 10/10/1995; 29(3): 740-50. PMID: 8575768, PII: S0888-7543(85)79943-0, DOI: 10.1006/geno.1995.9943, ISSN: 0888-7543.

Williams CP, Granner DK, Magnuson MA, Chalkley R. Cell specific differences in DNase I hypersensitivity between the two promoters of the rat glucokinase gene. Biochem. Biophys. Res. Commun. 1995 Oct 10/4/1995; 215(1): 272-9. PMID: 7575601, PII: S0006-291X(85)72462-X, DOI: 10.1006/bbrc.1995.2462, ISSN: 0006-291X.

Liang Y, Kesavan P, Wang LQ, Niswender K, Tanizawa Y, Permutt MA, Magnuson MA, Matschinsky FM. Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme. Biochem. J. 1995 Jul 7/1/1995; 309 ( Pt 1): 167-73. PMID: 7619052, PMCID: PMC1135815, ISSN: 0264-6021.

Franklin AJ, Jetton TL, Shelton KD, Magnuson MA. BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription. Mol. Cell. Biol. 1994 Oct; 14(10): 6773-88. PMID: 7935395, PMCID: PMC359208, ISSN: 0270-7306.

Morita H, Yano Y, Niswender KD, May JM, Whitesell RR, Wu L, Printz RL, Granner DK, Magnuson MA, Powers AC. Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization. J. Clin. Invest. 1994 Oct; 94(4): 1373-82. PMID: 7929812, PMCID: PMC295259, DOI: 10.1172/JCI117472, ISSN: 0021-9738.

Liang Y, Jetton TL, Zimmerman EC, Najafi H, Berner DK, Matschinsky FM, Magnuson MA. Effects of glucose on insulin secretion, glucokinase activity, and transgene expression in transgenic mouse islets containing an upstream glucokinase promoter-human growth hormone fusion gene. Diabetes. 1994 Sep; 43(9): 1138-45. PMID: 8070614, ISSN: 0012-1797.

Lazar J, Desvergne B, Zimmerman EC, Zimmer DB, Magnuson MA, Nikodem VM. A role for intronic sequences on expression of thyroid hormone receptor alpha gene. J. Biol. Chem. 1994 Aug 8/12/1994; 269(32): 20352-9. PMID: 8051130, ISSN: 0021-9258.

Efrat S, Leiser M, Wu YJ, Fusco-DeMane D, Emran OA, Surana M, Jetton TL, Magnuson MA, Weir G, Fleischer N. Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. Proc. Natl. Acad. Sci. U.S.A. 1994 Mar 3/15/1994; 91(6): 2051-5. PMID: 7510884, PMCID: PMC43307, ISSN: 0027-8424.

Jetton TL, Liang Y, Pettepher CC, Zimmerman EC, Cox FG, Horvath K, Matschinsky FM, Magnuson MA. Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut. J. Biol. Chem. 1994 Feb 2/4/1994; 269(5): 3641-54. PMID: 8106409, ISSN: 0021-9258.

Meyrick B, Magnuson MA. Identification and functional characterization of the bovine manganous superoxide dismutase promoter. Am. J. Respir. Cell Mol. Biol. 1994 Jan; 10(1): 113-21. PMID: 8292376, DOI: 10.1165/ajrcmb.10.1.8292376, ISSN: 1044-1549.

Kijima Y, Saito A, Jetton TL, Magnuson MA, Fleischer S. Different intracellular localization of inositol 1,4,5-trisphosphate and ryanodine receptors in cardiomyocytes. J. Biol. Chem. 1993 Feb 2/15/1993; 268(5): 3499-506. PMID: 8381433, ISSN: 0021-9258.

Magnuson MA, Jetton TL. Evolutionary conservation of elements in the upstream glucokinase promoter. Biochem. Soc. Trans. 1993 Feb; 21(1): 160-3. PMID: 8449284, ISSN: 0300-5127.

Brigham KL, Meyrick B, Christman B, Conary JT, King G, Berry LC, Magnuson MA. Expression of human growth hormone fusion genes in cultured lung endothelial cells and in the lungs of mice. Am. J. Respir. Cell Mol. Biol. 1993 Feb; 8(2): 209-13. PMID: 7678969, DOI: 10.1165/ajrcmb/8.2.209, ISSN: 1044-1549.

Printz RL, Magnuson MA, Granner DK. Mammalian glucokinase. Annu. Rev. Nutr. 1993; 13: 463-96. PMID: 8369155, DOI: 10.1146/annurev.nu.13.070193.002335, ISSN: 0199-9885.

Shelton KD, Franklin AJ, Khoor A, Beechem J, Magnuson MA. Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells. Mol. Cell. Biol. 1992 Oct; 12(10): 4578-89. PMID: 1406648, PMCID: PMC360385, ISSN: 0270-7306.

Liang Y, Najafi H, Smith RM, Zimmerman EC, Magnuson MA, Tal M, Matschinsky FM. Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture. Diabetes. 1992 Jul; 41(7): 792-806. PMID: 1612193, ISSN: 0012-1797.

Jetton TL, Magnuson MA. Heterogeneous expression of glucokinase among pancreatic beta cells. Proc. Natl. Acad. Sci. U.S.A. 1992 Apr 4/1/1992; 89(7): 2619-23. PMID: 1557365, PMCID: PMC48713, ISSN: 0027-8424.

Short MK, Clouthier DE, Schaefer IM, Hammer RE, Magnuson MA, Beale EG. Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice. Mol. Cell. Biol. 1992 Mar; 12(3): 1007-20. PMID: 1545785, PMCID: PMC369533, ISSN: 0270-7306.

Magnuson MA. Tissue-specific regulation of glucokinase gene expression. J. Cell. Biochem. 1992 Feb; 48(2): 115-21. PMID: 1618925, DOI: 10.1002/jcb.240480202, ISSN: 0730-2312.

Liang Y, Jetton TL, Zimmerman EC, Najafi H, Matschinsky FM, Magnuson MA. Effects of alternate RNA splicing on glucokinase isoform activities in the pancreatic islet, liver, and pituitary. J. Biol. Chem. 1991 Apr 4/15/1991; 266(11): 6999-7007. PMID: 2016311, ISSN: 0021-9258.

Zimmerman EC, Jones CM, Fet V, Hogan BL, Magnuson MA. Nucleotide sequence of mouse SCIP cDNA, a POU-domain transcription factor. Nucleic Acids Res. 1991 Feb 2/25/1991; 19(4): 956. PMID: 1840678, PMCID: PMC333739, ISSN: 0305-1048.

Forest CD, O'Brien RM, Lucas PC, Magnuson MA, Granner DK. Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence. Mol. Endocrinol. 1990 Sep; 4(9): 1302-10. PMID: 2172798, DOI: 10.1210/mend-4-9-1302, ISSN: 0888-8809.

O'Brien RM, Lucas PC, Forest CD, Magnuson MA, Granner DK. Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription. Science. 1990 Aug 8/3/1990; 249(4968): 533-7. PMID: 2166335, ISSN: 0036-8075.

Magnuson MA. Glucokinase gene structure. Functional implications of molecular genetic studies. Diabetes. 1990 May; 39(5): 523-7. PMID: 2185104, ISSN: 0012-1797.

Zimmer DB, Magnuson MA. Immunohistochemical localization of phosphoenolpyruvate carboxykinase in adult and developing mouse tissues. J. Histochem. Cytochem. 1990 Feb; 38(2): 171-8. PMID: 1688895, ISSN: 0022-1554.

Brigham KL, Meyrick B, Christman B, Magnuson M, King G, Berry LC. In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle. Am. J. Med. Sci. 1989 Oct; 298(4): 278-81. PMID: 2801762, ISSN: 0002-9629.

Magnuson MA, Shelton KD. An alternate promoter in the glucokinase gene is active in the pancreatic beta cell. J. Biol. Chem. 1989 Sep 9/25/1989; 264(27): 15936-42. PMID: 2550428, ISSN: 0021-9258.

Magnuson MA, Andreone TL, Printz RL, Koch S, Granner DK. Rat glucokinase gene: structure and regulation by insulin. Proc. Natl. Acad. Sci. U.S.A. 1989 Jul; 86(13): 4838-42. PMID: 2662183, PMCID: PMC297510, ISSN: 0027-8424.

Morioka H, Magnuson MA, Mitsuhashi T, Song MK, Rall JE, Nikodem VM. Structural characterization of the rat malic enzyme gene. Proc. Natl. Acad. Sci. U.S.A. 1989 Jul; 86(13): 4912-6. PMID: 2740332, PMCID: PMC297525, ISSN: 0027-8424.

Andreone TL, Printz RL, Pilkis SJ, Magnuson MA, Granner DK. The amino acid sequence of rat liver glucokinase deduced from cloned cDNA. J. Biol. Chem. 1989 Jan 1/5/1989; 264(1): 363-9. PMID: 2909525, ISSN: 0021-9258.

Nikodem VM, Magnuson MA, Dozin B, Morioka H. Coding nucleotide sequence of rat malic enzyme mRNA and tissue specific regulation by thyroid hormone. Endocr. Res. 1989; 15(4): 547-64. PMID: 2699453, ISSN: 0743-5800.

Quinn PG, Wong TW, Magnuson MA, Shabb JB, Granner DK. Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 1988 Aug; 8(8): 3467-75. PMID: 2850495, PMCID: PMC363584, ISSN: 0270-7306.

Petersen DD, Magnuson MA, Granner DK. Location and characterization of two widely separated glucocorticoid response elements in the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 1988 Jan; 8(1): 96-104. PMID: 3422101, PMCID: PMC363086, ISSN: 0270-7306.

Magnuson MA, Quinn PG, Granner DK. Multihormonal regulation of phosphoenolpyruvate carboxykinase-chloramphenicol acetyltransferase fusion genes. Insulin's effects oppose those of cAMP and dexamethasone. J. Biol. Chem. 1987 Nov 11/5/1987; 262(31): 14917-20. PMID: 2822706, ISSN: 0021-9258.

Tecce MF, Dozin B, Magnuson MA, Nikodem VM. Transcriptional regulation by thyroid hormone of an mRNA homologous to a protease inhibitor. Biochemistry. 1986 Sep 9/23/1986; 25(19): 5831-4. PMID: 3778884, ISSN: 0006-2960.

Dozin B, Magnuson MA, Nikodem VM. Thyroid hormone regulation of malic enzyme synthesis. Dual tissue-specific control. J. Biol. Chem. 1986 Aug 8/5/1986; 261(22): 10290-2. PMID: 3733710, ISSN: 0021-9258.

Magnuson MA, Morioka H, Tecce MF, Nikodem VM. Coding nucleotide sequence of rat liver malic enzyme mRNA. J. Biol. Chem. 1986 Jan 1/25/1986; 261(3): 1183-6. PMID: 3753699, ISSN: 0021-9258.

Dozin B, Magnuson MA, Nikodem VM. Tissue-specific regulation of two functional malic enzyme mRNAs by triiodothyronine. Biochemistry. 1985 Sep 9/24/1985; 24(20): 5581-6. PMID: 2416344, ISSN: 0006-2960.

Magnuson MA, Dozin B, Nikodem VM. Regulation of specific rat liver messenger ribonucleic acids by triiodothyronine. J. Biol. Chem. 1985 May 5/25/1985; 260(10): 5906-12. PMID: 2987208, ISSN: 0021-9258.

Magnuson MA, Nikodem VM. Molecular cloning of a cDNA sequence for rat malic enzyme. Direct evidence for induction in vivo of rat liver malic enzyme mRNA by thyroid hormone. J. Biol. Chem. 1983 Oct 10/25/1983; 258(20): 12712-7. PMID: 6195157, ISSN: 0021-9258.

Olson JD, Brockway WJ, Fass DN, Magnuson MA, Bowie EJ. Evaluation of ristocetin-Willebrand factor assay and ristocetin-induced platelet aggregation. Am. J. Clin. Pathol. 1975 Feb; 63(2): 210-8. PMID: 1078748, ISSN: 0002-9173.