Darren R. Tyson, Ph.D.

Research Assistant Professor

Faculty Appointments
Research Assistant Professor of Cancer Biology
Ph.D., Saint Louis University, Saint Louis, MissouriM.S., Saint Louis University, Saint Louis, MissouriB.S., University of Illinois, Urbana-Champaign, Illinois
Office Address
Cancer Biology - PRB 771
2220 Pierce Ave.
Nashville, TN 37232-6840
Research Keywords
Cell biology, prostate, 3D culture
Frick PL, Paudel BB, Tyson DR, Quaranta V. Quantifying heterogeneity and dynamics of clonal fitness in response to perturbation. J. Cell. Physiol. 2015 Jul; 230(7): 1403-12. PMID: 25600161, DOI: 10.1002/jcp.24888, ISSN: 1097-4652.

Wirtz ED, Hoshino D, Maldonado AT, Tyson DR, Weaver AM. Response of head and neck squamous cell carcinoma cells carrying PIK3CA mutations to selected targeted therapies. JAMA Otolaryngol Head Neck Surg. 2015 Jun; 141(6): 543-9. PMID: 25855885, PMCID: PMC4474763, PII: 2213736, DOI: 10.1001/jamaoto.2015.0471, ISSN: 2168-619X.

Leander R, Allen EJ, Garbett SP, Tyson DR, Quaranta V. Derivation and experimental comparison of cell-division probability densities. J. Theor. Biol [print-electronic]. 2014 Oct 10/21/2014; 359: 129-35. PMID: 24931675, PII: S0022-5193(14)00341-5, DOI: 10.1016/j.jtbi.2014.06.004, ISSN: 1095-8541.

Sewell A, Brown B, Biktasova A, Mills GB, Lu Y, Tyson DR, Issaeva N, Yarbrough WG. Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations in HPV-associated head and neck cancer. Clin. Cancer Res [print-electronic]. 2014 May 5/1/2014; 20(9): 2300-11. PMID: 24599934, PMCID: PMC4027970, PII: 1078-0432.CCR-13-2585, DOI: 10.1158/1078-0432.CCR-13-2585, ISSN: 1078-0432.

Quaranta V, Tyson DR. What lies beneath: looking beyond tumor genetics shows the complexity of signaling networks underlying drug sensitivity. Sci Signal. 2013 Sep 9/24/2013; 6(294): pe32. PMID: 24065144, PII: 6/294/pe32, DOI: 10.1126/scisignal.2004715, ISSN: 1937-9145.

Tyson DR, Quaranta V. Beyond genetics in personalized cancer treatment: assessing dynamics and heterogeneity of tumor responses. Per Med. 2013 May 5/1/2013; 10(3): 221-5. PMID: 24696699, PMCID: PMC3970774, DOI: 10.2217/pme.13.6, ISSN: 1741-0541.

Tyson DR, Garbett SP, Frick PL, Quaranta V. Fractional proliferation: a method to deconvolve cell population dynamics from single-cell data. Nat. Methods [print-electronic]. 2012 Sep; 9(9): 923-8. PMID: 22886092, PMCID: PMC3459330, PII: nmeth.2138, DOI: 10.1038/nmeth.2138, ISSN: 1548-7105.

Quaranta V, Tyson DR, Garbett SP, Weidow B, Harris MP, Georgescu W. Trait variability of cancer cells quantified by high-content automated microscopy of single cells. Meth. Enzymol. 2009; 467: 23-57. PMID: 19897088, PMCID: PMC2915824, PII: S0076-6879(09)67002-6, DOI: 10.1016/S0076-6879(09)67002-6, ISSN: 1557-7988.

Shukla D, Box GN, Edwards RA, Tyson DR. Bone marrow stem cells for urologic tissue engineering. World J Urol [print-electronic]. 2008 Aug; 26(4): 341-9. PMID: 18654786, DOI: 10.1007/s00345-008-0311-y, ISSN: 0724-4983.

Tyson DR, Ornstein DK. Proteomics of cancer of hormone-dependent tissues. Adv. Exp. Med. Biol. 2008; 630: 133-47. PMID: 18637489, ISSN: 0065-2598.

Tyson DR, Inokuchi J, Tsunoda T, Lau A, Ornstein DK. Culture requirements of prostatic epithelial cell lines for acinar morphogenesis and lumen formation in vitro: role of extracellular calcium. Prostate. 2007 Nov 11/1/2007; 67(15): 1601-13. PMID: 17705248, DOI: 10.1002/pros.20628, ISSN: 0270-4137.

Hsiang CH, Tunoda T, Whang YE, Tyson DR, Ornstein DK. The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells. Prostate. 2006 Sep 9/15/2006; 66(13): 1413-24. PMID: 16741918, DOI: 10.1002/pros.20457, ISSN: 0270-4137.

Ornstein DK, Tyson DR. Proteomics for the identification of new prostate cancer biomarkers. Urol. Oncol. 2006 May; 24(3): 231-6. PMID: 16678055, PII: S1078-1439(05)00281-4, DOI: 10.1016/j.urolonc.2005.11.035, ISSN: 1078-1439.

Medzihradszky KF, Darula Z, Perlson E, Fainzilber M, Chalkley RJ, Ball H, Greenbaum D, Bogyo M, Tyson DR, Bradshaw RA, Burlingame AL. O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes. Mol. Cell Proteomics [print-electronic]. 2004 May; 3(5): 429-40. PMID: 14752058, PII: M300140-MCP200, DOI: 10.1074/mcp.M300140-MCP200, ISSN: 1535-9476.

Jimenez JC, Tyson DR, Dhar S, Nguyen T, Hamai Y, Bradshaw RA, Evans GR. Human embryonic kidney cells (HEK-293 cells): characterization and dose-response relationship for modulated release of nerve growth factor for nerve regeneration. Plast. Reconstr. Surg. 2004 Feb; 113(2): 605-10. PMID: 14758223, PII: 00006534-200402000-00020, DOI: 10.1097/01.PRS.0000101066.76548.E8, ISSN: 0032-1052.

Tyson DR, Larkin S, Hamai Y, Bradshaw RA. PC12 cell activation by epidermal growth factor receptor: role of autophosphorylation sites. Int. J. Dev. Neurosci. 2003 Apr; 21(2): 63-74. PMID: 12615082, PII: S0736574802001399, ISSN: 0736-5748.

Swarthout JT, Tyson DR, Jefcoat SC, Partridge NC. Induction of transcriptional activity of the cyclic adenosine monophosphate response element binding protein by parathyroid hormone and epidermal growth factor in osteoblastic cells. J. Bone Miner. Res. 2002 Aug; 17(8): 1401-7. PMID: 12162494, DOI: 10.1359/jbmr.2002.17.8.1401, ISSN: 0884-0431.

Tyson DR, Swarthout JT, Jefcoat SC, Partridge NC. PTH induction of transcriptional activity of the cAMP response element-binding protein requires the serine 129 site and glycogen synthase kinase-3 activity, but not casein kinase II sites. Endocrinology. 2002 Feb; 143(2): 674-82. PMID: 11796524, DOI: 10.1210/endo.143.2.8626, ISSN: 0013-7227.

Bajaj MS, Tyson DR, Steer SA, Kuppuswamy MN. Role of GATA motifs in tissue factor pathway inhibitor gene expression in malignant cells. Thromb. Res. 2001 Feb 2/1/2001; 101(3): 203-11. PMID: 11228343, PII: S0049-3848(00)00393-5, ISSN: 0049-3848.

Selvamurugan N, Pulumati MR, Tyson DR, Partridge NC. Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor alpha1. J. Biol. Chem. 2000 Feb 2/18/2000; 275(7): 5037-42. PMID: 10671545, ISSN: 0021-9258.

Tyson DR, Swarthout JT, Partridge NC. Increased osteoblastic c-fos expression by parathyroid hormone requires protein kinase A phosphorylation of the cyclic adenosine 3',5'-monophosphate response element-binding protein at serine 133. Endocrinology. 1999 Mar; 140(3): 1255-61. PMID: 10067851, DOI: 10.1210/endo.140.3.6567, ISSN: 0013-7227.

Koe RC, Clohisy JC, Tyson DR, Pulumati MR, Cook TF, Partridge NC. Parathyroid hormone versus phorbol ester stimulation of activator protein-1 gene family members in rat osteosarcoma cells. Calcif. Tissue Int. 1997 Jul; 61(1): 52-8. PMID: 9192514, ISSN: 0171-967X.

Tyson DR, Kuppuswamy MN, Broze GJ, Bajaj SP. Revised DNA sequence of exon 1 and 5' flanking region of the human tissue factor pathway inhibitor gene. Thromb. Res. 1993 May 5/1/1993; 70(3): 269-73. PMID: 8327992, PII: 0049-3848(93)90134-A, ISSN: 0049-3848.