Maureen Anne Gannon, Ph.D.

Professor

maureen.gannon@vanderbilt.edu

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Faculty Appointments
Professor of Medicine Professor of Cell and Developmental BiologyProfessor of Molecular Physiology and Biophysics
Education
Ph.D., Cell Biology, Cornell University Medical College, New York, New YorkM.S., Biology, Adelphi University, Garden City, New YorkB.S., Biology, Molloy College , Rockville Center, New York
Office Address
Division of Diabetes, Endocrinology and Metabolism
7425 MRBIV Langford
2213 Garland Avenue
Nashville, TN 37232-0475
Research Description
The pancreas is essential for normal digestion and maintenance of blood sugar levels. We study the role of genes and signaling pathways involved in the development and function of specific cell types within the pancreas.
The Oc1 (aka, HNF6) transcription factor is expressed in all pancreas cells early in embryonic development, but is "turned off" in islet cells just before birth in the mouse. We developed mice in which Oc1 is over-expressed or can be inactivated conditionally. These studies reveal that Oc1 is essential to generate the appropriate number of endocrine progenitor cells, but that it must get "turned off" in order for the insulin-producing cells to function properly. Current studies are examining how Oc1 interacts with other transcription factors in the developing pancreas to regulate endocrine differentiation and the function of mature insulin-producing beta cells. We are testing the hypothesis that Oc1 cooperates with other factors to establish an epigenetic landscape permissive for endocrine differentiation.
A second project in the lab examines the role of CTGF, a secreted factor known to modulate growth factor signaling and affect cell proliferation and migration in other organ systems. We found that loss of CTGF results in decreased embryonic islet beta cell proliferation and defective islet formation. We are using conditional gene inactivation and over-expression strategies to determine how CTGF affects islet development and function during embryogenesis and after transplantation. In addition, we are have determined that CTGF can enhance beta cell regeneration in adults after significant beta cell destruction. We are now dissecting the signaling pathways through which CTGF affects beta cell proliferation and regeneration.
Finally, the FoxM1 transcription factor is highly expressed in proliferating cells and is essential for normal cell division. We found that FoxM1 is required downstream of all proliferative stimuli in the insulin-producing beta cells. We have identified two prostaglandin receptors as being downstream of FoxM1 to mediate its effects on beta cell proliferation and survival. We are currently using mouse models to test whether modulating the activity of these receptors in vivo enhances beta cell proliferation and survival.
Research Keywords
Molecular genetics of pancreas development, organogenesis, morphogenesis, islet function, diabetes, transcription factors, pancreatic cancer
Publications
Pasek RC, Dunn JC, Elsakr JM, Aramandla M, Matta AR, Gannon M. Vascular-derived connective tissue growth factor (Ctgf) is critical for pregnancy-induced ß cell hyperplasia in adult mice. Islets [print-electronic]. 2017 Nov 11/7/2017; e1356963. PMID: 29111856, DOI: 10.1080/19382014.2017.1356963, ISSN: 1938-2022.

Trefts E, Gannon M, Wasserman DH. The liver. Curr. Biol. 2017 Nov 11/6/2017; 27(21): R1147-R1151. PMID: 29112863, PII: S0960-9822(17)31183-1, DOI: 10.1016/j.cub.2017.09.019, ISSN: 1879-0445.

Money KM, Barke TL, Serezani A, Gannon M, Garbett KA, Aronoff DM, Mirnics K. Gestational diabetes exacerbates maternal immune activation effects in the developing brain. Mol. Psychiatry [print-electronic]. 2017 Sep 9/26/2017; PMID: 28948973, PII: mp2017191, DOI: 10.1038/mp.2017.191, ISSN: 1476-5578.

Carboneau BA, Allan JA, Townsend SE, Kimple ME, Breyer RM, Gannon M. Opposing effects of prostaglandin E2 receptors EP3 and EP4 on mouse and human ß-cell survival and proliferation. Mol Metab. 2017 Jun; 6(6): 548-59. PMID: 28580285, PMCID: PMC5444094, PII: S2212-8778(17)30106-0, DOI: 10.1016/j.molmet.2017.04.002, ISSN: 2212-8778.

Carboneau BA, Breyer RM, Gannon M. Regulation of pancreatic ß-cell function and mass dynamics by prostaglandin signaling. J Cell Commun Signal [print-electronic]. 2017 Jun; 11(2): 105-16. PMID: 28132118, PMCID: PMC5440348, PII: 10.1007/s12079-017-0377-7, DOI: 10.1007/s12079-017-0377-7, ISSN: 1873-9601.

Pasek RC, Kavanaugh TE, Duvall CL, Gannon MA. Sustained Administration of ß-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres. J Vis Exp. 2016 Nov 11/5/2016; (117): PMID: 27842374, DOI: 10.3791/54664, ISSN: 1940-087X.

Carboneau BA, Le TD, Dunn JC, Gannon M. Unexpected effects of the MIP-CreER transgene and tamoxifen on ß-cell growth in C57Bl6/J male mice. Physiol Rep. 2016 Sep; 4(18): PMID: 27670405, PMCID: PMC5037909, PII: 4/18/e12863, DOI: 10.14814/phy2.12863, ISSN: 2051-817X.

Pasek RC, Dunn JC, Elsakr JM, Aramandla M, Matta AR, Gannon M. Connective tissue growth factor is critical for proper ß-cell function and pregnancy-induced ß-cell hyperplasia in adult mice. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2016 Sep 9/1/2016; 311(3): E564-74. PMID: 27460898, PMCID: PMC5142004, PII: ajpendo.00194.2016, DOI: 10.1152/ajpendo.00194.2016, ISSN: 1522-1555.

Zhang Y, Fang B, Damle M, Guan D, Li Z, Kim YH, Gannon M, Lazar MA. HNF6 and Rev-erba integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms. Genes Dev [print-electronic]. 2016 Jul 7/15/2016; 30(14): 1636-44. PMID: 27445394, PMCID: PMC4973293, PII: gad.281972.116, DOI: 10.1101/gad.281972.116, ISSN: 1549-5477.

Henley KD, Stanescu DE, Kropp PA, Wright CV, Won KJ, Stoffers DA, Gannon M. Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and ß-Cell Function. Cell Rep [print-electronic]. 2016 Jun 6/21/2016; 15(12): 2637-50. PMID: 27292642, PMCID: PMC4917419, PII: S2211-1247(16)30623-4, DOI: 10.1016/j.celrep.2016.05.040, ISSN: 2211-1247.

Kubo F, Miyatsuka T, Sasaki S, Takahara M, Yamamoto Y, Shimo N, Watada H, Kaneto H, Gannon M, Matsuoka TA, Shimomura I. Sustained expression of GLP-1 receptor differentially modulates ß-cell functions in diabetic and nondiabetic mice. Biochem. Biophys. Res. Commun [print-electronic]. 2016 Feb 2/26/2016; 471(1): 68-74. PMID: 26854076, PII: S0006-291X(16)30177-2, DOI: 10.1016/j.bbrc.2016.01.177, ISSN: 1090-2104.

Villa SR, Priyadarshini M, Fuller MH, Bhardwaj T, Brodsky MR, Angueira AR, Mosser RE, Carboneau BA, Tersey SA, Mancebo H, Gilchrist A, Mirmira RG, Gannon M, Layden BT. Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival. Sci Rep. 2016; 6: 28159. PMID: 27324831, PMCID: PMC4914960, PII: srep28159, DOI: 10.1038/srep28159, ISSN: 2045-2322.

Kodama S, Nakano Y, Hirata K, Furuyama K, Horiguchi M, Kuhara T, Masui T, Kawaguchi M, Gannon M, Wright CV, Uemoto S, Kawaguchi Y. Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice. Sci Rep. 2016; 6: 21211. PMID: 26887806, PMCID: PMC4758062, PII: srep21211, DOI: 10.1038/srep21211, ISSN: 2045-2322.

Ceddia RP, Lee D, Maulis MF, Carboneau BA, Threadgill DW, Poffenberger G, Milne G, Boyd KL, Powers AC, McGuinness OP, Gannon M, Breyer RM. The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice. Endocrinology [print-electronic]. 2016 Jan; 157(1): 220-32. PMID: 26485614, PMCID: PMC4701878, DOI: 10.1210/en.2015-1693, ISSN: 1945-7170.

Kropp PA, Gannon M. Onecut transcription factors in development and disease. Trends Dev Biol. 2016; 9: 43-57. PMID: 28018056, PMCID: PMC5176019, ISSN: 0972-8422.

Wang K, Wang M, Gannon M, Holterman A. Growth Hormone Mediates Its Protective Effect in Hepatic Apoptosis through Hnf6. PLoS ONE. 2016; 11(12): e0167085. PMID: 27936029, PMCID: PMC5147851, PII: PONE-D-16-24121, DOI: 10.1371/journal.pone.0167085, ISSN: 1932-6203.

Golson ML, Dunn JC, Maulis MF, Dadi PK, Osipovich AB, Magnuson MA, Jacobson DA, Gannon M. Activation of FoxM1 Revitalizes the Replicative Potential of Aged ß-Cells in Male Mice and Enhances Insulin Secretion. Diabetes [print-electronic]. 2015 Nov; 64(11): 3829-38. PMID: 26251404, PMCID: PMC4613976, PII: db15-0465, DOI: 10.2337/db15-0465, ISSN: 1939-327X.

Riley KG, Pasek RC, Maulis MF, Dunn JC, Bolus WR, Kendall PL, Hasty AH, Gannon M. Macrophages are essential for CTGF-mediated adult ß-cell proliferation after injury. Mol Metab. 2015 Aug; 4(8): 584-91. PMID: 26266091, PMCID: PMC4529497, PII: S2212-8778(15)00091-5, DOI: 10.1016/j.molmet.2015.05.002, ISSN: 2212-8778.

Mosser RE, Maulis MF, Moullé VS, Dunn JC, Carboneau BA, Arasi K, Pappan K, Poitout V, Gannon M. High-fat diet-induced ß-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2015 Apr 4/1/2015; 308(7): E573-82. PMID: 25628421, PMCID: PMC4385873, PII: ajpendo.00460.2014, DOI: 10.1152/ajpendo.00460.2014, ISSN: 1522-1555.

Riley KG, Pasek RC, Maulis MF, Peek J, Thorel F, Brigstock DR, Herrera PL, Gannon M. Connective tissue growth factor modulates adult ß-cell maturity and proliferation to promote ß-cell regeneration in mice. Diabetes [print-electronic]. 2015 Apr; 64(4): 1284-98. PMID: 25392241, PMCID: PMC4375083, PII: db14-1195, DOI: 10.2337/db14-1195, ISSN: 1939-327X.

Matsuoka TA, Kaneto H, Kawashima S, Miyatsuka T, Tochino Y, Yoshikawa A, Imagawa A, Miyazaki J, Gannon M, Stein R, Shimomura I. Preserving Mafa expression in diabetic islet ß-cells improves glycemic control in vivo. J. Biol. Chem [print-electronic]. 2015 Mar 3/20/2015; 290(12): 7647-57. PMID: 25645923, PMCID: PMC4367268, PII: M114.595579, DOI: 10.1074/jbc.M114.595579, ISSN: 1083-351X.

Golson ML, Maulis MF, Dunn JC, Poffenberger G, Schug J, Kaestner KH, Gannon MA. Activated FoxM1 attenuates streptozotocin-mediated ß-cell death. Mol. Endocrinol [print-electronic]. 2014 Sep; 28(9): 1435-47. PMID: 25073103, PMCID: PMC4154244, DOI: 10.1210/me.2014-1024, ISSN: 1944-9917.

Pekala KR, Ma X, Kropp PA, Petersen CP, Hudgens CW, Chung CH, Shi C, Merchant NB, Maitra A, Means AL, Gannon MA. Loss of HNF6 expression correlates with human pancreatic cancer progression. Lab. Invest [print-electronic]. 2014 May; 94(5): 517-27. PMID: 24638272, PMCID: PMC4068339, PII: labinvest201447, DOI: 10.1038/labinvest.2014.47, ISSN: 1530-0307.

Mosser RE, Gannon M. An assay for small scale screening of candidate ß cell proliferative factors using intact islets. BioTechniques. 2013 Dec; 55(6): 310-2. PMID: 24344680, PII: 000114115, DOI: 10.2144/000114115, ISSN: 1940-9818.

Alfaro MP, Deskins DL, Wallus M, DasGupta J, Davidson JM, Nanney LB, A Guney M, Gannon M, Young PP. A physiological role for connective tissue growth factor in early wound healing. Lab. Invest [print-electronic]. 2013 Jan; 93(1): 81-95. PMID: 23212098, PMCID: PMC3720136, PII: labinvest2012162, DOI: 10.1038/labinvest.2012.162, ISSN: 1530-0307.

Henley KD, Gooding KA, Economides AN, Gannon M. Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2012 Sep 9/15/2012; 303(6): E752-61. PMID: 22829579, PMCID: PMC3468431, PII: ajpendo.00531.2011, DOI: 10.1152/ajpendo.00531.2011, ISSN: 1522-1555.

Gunasekaran U, Hudgens CW, Wright BT, Maulis MF, Gannon M. Differential regulation of embryonic and adult ß cell replication. Cell Cycle [print-electronic]. 2012 Jul 7/1/2012; 11(13): 2431-42. PMID: 22659844, PMCID: PMC3404874, PII: 20545, DOI: 10.4161/cc.20545, ISSN: 1551-4005.

Reinert RB, Kantz J, Misfeldt AA, Poffenberger G, Gannon M, Brissova M, Powers AC. Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice. PLoS ONE [print-electronic]. 2012; 7(3): e33529. PMID: 22470452, PMCID: PMC3314663, PII: PONE-D-11-23105, DOI: 10.1371/journal.pone.0033529, ISSN: 1932-6203.

Vanderpool C, Sparks EE, Huppert KA, Gannon M, Means AL, Huppert SS. Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo. Hepatology. 2012 Jan; 55(1): 233-43. PMID: 21898486, PMCID: PMC3235248, DOI: 10.1002/hep.24631, ISSN: 1527-3350.

Guney MA, Petersen CP, Boustani A, Duncan MR, Gunasekaran U, Menon R, Warfield C, Grotendorst GR, Means AL, Economides AN, Gannon M. Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2011 Sep 9/13/2011; 108(37): 15242-7. PMID: 21876171, PMCID: PMC3174622, PII: 1100072108, DOI: 10.1073/pnas.1100072108, ISSN: 1091-6490.

Gunasekaran U, Gannon M. Type 2 diabetes and the aging pancreatic beta cell. Aging (Albany NY). 2011 Jun; 3(6): 565-75. PMID: 21765202, PMCID: PMC3164365, PII: 100350, ISSN: 1945-4589.

Moore MC, Menon R, Coate KC, Gannon M, Smith MS, Farmer B, Williams PE. Diet-induced impaired glucose tolerance and gestational diabetes in the dog. J. Appl. Physiol [print-electronic]. 2011 Feb; 110(2): 458-67. PMID: 21088210, PMCID: PMC3043793, PII: japplphysiol.00768.2010, DOI: 10.1152/japplphysiol.00768.2010, ISSN: 1522-1601.

Blaine SA, Ray KC, Anunobi R, Gannon MA, Washington MK, Means AL. Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling. Development [print-electronic]. 2010 Jul; 137(14): 2289-96. PMID: 20534672, PMCID: PMC2889602, PII: dev.048421, DOI: 10.1242/dev.048421, ISSN: 1477-9129.

Zhang H, Zhang J, Pope CF, Crawford LA, Vasavada RC, Jagasia SM, Gannon M. Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen. Diabetes [print-electronic]. 2010 Jan; 59(1): 143-52. PMID: 19833884, PMCID: PMC2797915, PII: db09-0050, DOI: 10.2337/db09-0050, ISSN: 1939-327X.

Virostko J, Radhika A, Poffenberger G, Chen Z, Brissova M, Gilchrist J, Coleman B, Gannon M, Jansen ED, Powers AC. Bioluminescence imaging in mouse models quantifies beta cell mass in the pancreas and after islet transplantation. Mol Imaging Biol [print-electronic]. 2010 Jan; 12(1): 42-53. PMID: 19548035, PMCID: PMC3822006, DOI: 10.1007/s11307-009-0240-1, ISSN: 1860-2002.

Golson ML, Misfeldt AA, Kopsombut UG, Petersen CP, Gannon M. High Fat Diet Regulation of ß-Cell Proliferation and ß-Cell Mass. Open Endocrinol J. 2010; 4: PMID: 24339840, PMCID: PMC3856766, DOI: 10.2174/1874216501004010066, ISSN: 1874-2165.

Zhang H, Ables ET, Pope CF, Washington MK, Hipkens S, Means AL, Path G, Seufert J, Costa RH, Leiter AB, Magnuson MA, Gannon M. Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech. Dev [print-electronic]. 2009 Dec; 126(11-12): 958-73. PMID: 19766716, PMCID: PMC2783291, PII: S0925-4773(09)01453-1, DOI: 10.1016/j.mod.2009.09.006, ISSN: 1872-6356.

Guney MA, Gannon M. Pancreas cell fate. Birth Defects Res. C Embryo Today. 2009 Sep; 87(3): 232-48. PMID: 19750517, PMCID: PMC2755625, DOI: 10.1002/bdrc.20156, ISSN: 1542-9768.

Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M. Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Mol. Endocrinol [print-electronic]. 2009 Mar; 23(3): 324-36. PMID: 19131512, PMCID: PMC2654514, PII: me.2008-0045, DOI: 10.1210/me.2008-0045, ISSN: 0888-8809.

Elghazi L, Weiss AJ, Barker DJ, Callaghan J, Staloch L, Sandgren EP, Gannon M, Adsay VN, Bernal-Mizrachi E. Regulation of pancreas plasticity and malignant transformation by Akt signaling. Gastroenterology [print-electronic]. 2009 Mar; 136(3): 1091-103. PMID: 19121634, PMCID: PMC2739876, PII: S0016-5085(08)02074-X, DOI: 10.1053/j.gastro.2008.11.043, ISSN: 1528-0012.

Ackermann Misfeldt A, Costa RH, Gannon M. Beta-cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1. Diabetes [print-electronic]. 2008 Nov; 57(11): 3069-77. PMID: 18728229, PMCID: PMC2570403, PII: db08-0878, DOI: 10.2337/db08-0878, ISSN: 1939-327X.

Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV. Pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev. Biol [print-electronic]. 2008 Feb 2/15/2008; 314(2): 406-17. PMID: 18155690, PMCID: PMC2269701, PII: S0012-1606(07)01464-9, DOI: 10.1016/j.ydbio.2007.10.038, ISSN: 1095-564X.

Wilding Crawford L, Tweedie Ables E, Oh YA, Boone B, Levy S, Gannon M. Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis. PLoS ONE. 2008; 3(2): e1611. PMID: 18297134, PMCID: PMC2249940, DOI: 10.1371/journal.pone.0001611, ISSN: 1932-6203.

Wiebe PO, Kormish JD, Roper VT, Fujitani Y, Alston NI, Zaret KS, Wright CV, Stein RW, Gannon M. Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Mol. Cell. Biol [print-electronic]. 2007 Jun; 27(11): 4093-104. PMID: 17403901, PMCID: PMC1900007, PII: MCB.01978-06, DOI: 10.1128/MCB.01978-06, ISSN: 0270-7306.

Kanetsuna Y, Takahashi K, Nagata M, Gannon MA, Breyer MD, Harris RC, Takahashi T. Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice. Am. J. Pathol. 2007 May; 170(5): 1473-84. PMID: 17456755, PMCID: PMC1854944, PII: S0002-9440(10)61362-4, DOI: 10.2353/ajpath.2007.060481, ISSN: 0002-9440.

Gannon M. BuMP-ing up insulin secretion by pancreatic beta cells. Cell Metab. 2007 Mar; 5(3): 157-9. PMID: 17339021, PII: S1550-4131(07)00035-6, DOI: 10.1016/j.cmet.2007.02.003, ISSN: 1550-4131.

Ackermann AM, Gannon M. Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. J. Mol. Endocrinol. 2007 Feb; 38(1-2): 193-206. PMID: 17293440, PII: 38/2/193, DOI: 10.1677/JME-06-0053, ISSN: 0952-5041.

Kanetsuna Y, Hirano K, Nagata M, Gannon MA, Takahashi K, Harris RC, Breyer MD, Takahashi T. Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes. Am. J. Physiol. Renal Physiol [print-electronic]. 2006 Dec; 291(6): F1315-22. PMID: 16705146, PII: 00379.2005, DOI: 10.1152/ajprenal.00379.2005, ISSN: 1931-857X.

Tweedie E, Artner I, Crawford L, Poffenberger G, Thorens B, Stein R, Powers AC, Gannon M. Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells. Diabetes. 2006 Dec; 55(12): 3264-70. PMID: 17130469, PII: 55/12/3264, DOI: 10.2337/db06-0090, ISSN: 0012-1797.

Brissova M, Shostak A, Shiota M, Wiebe PO, Poffenberger G, Kantz J, Chen Z, Carr C, Jerome WG, Chen J, Baldwin HS, Nicholson W, Bader DM, Jetton T, Gannon M, Powers AC. Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes. 2006 Nov; 55(11): 2974-85. PMID: 17065333, PII: 55/11/2974, DOI: 10.2337/db06-0690, ISSN: 0012-1797.

Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV. Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev. Biol [print-electronic]. 2006 Oct 10/15/2006; 298(2): 616-31. PMID: 16962573, PII: S0012-1606(06)01026-8, DOI: 10.1016/j.ydbio.2006.07.020, ISSN: 0012-1606.

Zhang H, Ackermann AM, Gusarova GA, Lowe D, Feng X, Kopsombut UG, Costa RH, Gannon M. The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass. Mol. Endocrinol [print-electronic]. 2006 Aug; 20(8): 1853-66. PMID: 16556734, PII: me.2006-0056, DOI: 10.1210/me.2006-0056, ISSN: 0888-8809.

Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA, Wright CV. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev. 2006 Jan 1/15/2006; 20(2): 253-66. PMID: 16418487, PMCID: PMC1356115, PII: 20/2/253, DOI: 10.1101/gad.1360106, ISSN: 0890-9369.

Zhang H, Fujitani Y, Wright CV, Gannon M. Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase. Genesis. 2005 Jul; 42(3): 210-7. PMID: 15986486, DOI: 10.1002/gene.20137, ISSN: 1526-954X.

Frigeri C, Martin CC, Svitek CA, Oeser JK, Hutton JC, Gannon M, O'Brien RM. The proximal islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen promoter is sufficient to initiate but not maintain transgene expression in mouse islets in vivo. Diabetes. 2004 Jul; 53(7): 1754-64. PMID: 15220199, PII: 53/7/1754, ISSN: 0012-1797.

Brissova M, Fowler M, Wiebe P, Shostak A, Shiota M, Radhika A, Lin PC, Gannon M, Powers AC. Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets. Diabetes. 2004 May; 53(5): 1318-25. PMID: 15111502, ISSN: 0012-1797.

Wilding L, Gannon M. The role of pdx1 and HNF6 in proliferation and differentiation of endocrine precursors. Diabetes Metab. Res. Rev. 2004 Mar; 20(2): 114-23. PMID: 15037986, DOI: 10.1002/dmrr.429, ISSN: 1520-7552.

Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat. Genet [print-electronic]. 2002 Sep; 32(1): 128-34. PMID: 12185368, PII: ng959, DOI: 10.1038/ng959, ISSN: 1061-4036.

Samaras SE, Cissell MA, Gerrish K, Wright CV, Gannon M, Stein R. Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Mol. Cell. Biol. 2002 Jul; 22(13): 4702-13. PMID: 12052878, PMCID: PMC133887, ISSN: 0270-7306.

Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR. The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol. Cell. Biol. 2002 Jun; 22(11): 3864-74. PMID: 11997520, PMCID: PMC133833, ISSN: 0270-7306.

Brissova M, Shiota M, Nicholson WE, Gannon M, Knobel SM, Piston DW, Wright CV, Powers AC. Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J. Biol. Chem [print-electronic]. 2002 Mar 3/29/2002; 277(13): 11225-32. PMID: 11781323, PII: M111272200, DOI: 10.1074/jbc.M111272200, ISSN: 0021-9258.

Gannon M, Gamer LW, Wright CV. Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1. Dev. Biol. 2001 Oct 10/1/2001; 238(1): 185-201. PMID: 11784003, PII: S0012-1606(01)90359-8, DOI: 10.1006/dbio.2001.0359, ISSN: 0012-1606.

Gannon M. Molecular genetic analysis of diabetes in mice. Trends Genet. 2001 Oct; 17(10): S23-8. PMID: 11585673, PII: S0168-9525(01)02453-2, ISSN: 0168-9525.

Dutta S, Gannon M, Peers B, Wright C, Bonner-Weir S, Montminy M. PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2001 Jan 1/30/2001; 98(3): 1065-70. PMID: 11158595, PMCID: PMC14709, PII: 031561298, DOI: 10.1073/pnas.031561298, ISSN: 0027-8424.

Gannon M, Ray MK, Van Zee K, Rausa F, Costa RH, Wright CV. Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function. Development. 2000 Jul; 127(13): 2883-95. PMID: 10851133, ISSN: 0950-1991.

Gannon M, Gilday D, Rifkind AB. TCDD induces CYP1A4 and CYP1A5 in chick liver and kidney and only CYP1A4, an enzyme lacking arachidonic acid epoxygenase activity, in myocardium and vascular endothelium. Toxicol. Appl. Pharmacol. 2000 Apr 4/1/2000; 164(1): 24-37. PMID: 10739741, PII: S0041-008X(99)98864-6, DOI: 10.1006/taap.1999.8864, ISSN: 0041-008X.

Gerrish K, Gannon M, Shih D, Henderson E, Stoffel M, Wright CV, Stein R. Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites. J. Biol. Chem. 2000 Feb 2/4/2000; 275(5): 3485-92. PMID: 10652343, ISSN: 0021-9258.

Gannon M, Herrera PL, Wright CV. Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter. Genesis. 2000 Feb; 26(2): 143-4. PMID: 10686611, PII: 10.1002/(SICI)1526-968X(200002)26:2<143::AID-GENE13>3.0.CO;2-L, ISSN: 1526-954X.

Gannon M, Shiota C, Postic C, Wright CV, Magnuson M. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis. 2000 Feb; 26(2): 139-42. PMID: 10686610, PII: 10.1002/(SICI)1526-968X(200002)26:2<139::AID-GENE12>3.0.CO;2-7, ISSN: 1526-954X.

Song SY, Gannon M, Washington MK, Scoggins CR, Meszoely IM, Goldenring JR, Marino CR, Sandgren EP, Coffey RJ, Wright CV, Leach SD. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology. 1999 Dec; 117(6): 1416-26. PMID: 10579983, PII: S0016508599005648, ISSN: 0016-5085.

Wu KL, Gannon M, Peshavaria M, Offield MF, Henderson E, Ray M, Marks A, Gamer LW, Wright CV, Stein R. Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Mol. Cell. Biol. 1997 Oct; 17(10): 6002-13. PMID: 9315659, PMCID: PMC232449, ISSN: 0270-7306.

Gannon M, Bader D. Avian cardiac progenitors: methods for isolation, culture, and analysis of differentiation. Methods Cell Biol. 1997; 52: 117-32. PMID: 9379947, ISSN: 0091-679X.

Gilday D, Gannon M, Yutzey K, Bader D, Rifkind AB. Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Biol. Chem. 1996 Dec 12/20/1996; 271(51): 33054-9. PMID: 8955152, ISSN: 0021-9258.

Gannon M, Bader D. Initiation of cardiac differentiation occurs in the absence of anterior endoderm. Development. 1995 Aug; 121(8): 2439-50. PMID: 7671808, ISSN: 0950-1991.

Yutzey K, Gannon M, Bader D. Diversification of cardiomyogenic cell lineages in vitro. Dev. Biol. 1995 Aug; 170(2): 531-41. PMID: 7649381, PII: S0012160685712341, ISSN: 0012-1606.

Melnik N, Yutzey KE, Gannon M, Bader D. Commitment, differentiation, and diversification of avian cardiac progenitor cells. Ann. N. Y. Acad. Sci. 1995 Mar 3/27/1995; 752: 1-8. PMID: 7755245, ISSN: 0077-8923.

Nakai K, Ward AM, Gannon M, Rifkind AB. Beta-naphthoflavone induction of a cytochrome P-450 arachidonic acid epoxygenase in chick embryo liver distinct from the aryl hydrocarbon hydroxylase and from phenobarbital-induced arachidonate epoxygenase. J. Biol. Chem. 1992 Sep 9/25/1992; 267(27): 19503-12. PMID: 1527070, ISSN: 0021-9258.

Wang G, Higgins PJ, Gannon M, Staiano-Coico L. Transforming growth factor-beta 1 acts cooperatively with sodium n-butyrate to induce differentiation of normal human keratinocytes. Exp. Cell Res. 1992 Jan; 198(1): 27-30. PMID: 1727055, PII: 0014-4827(92)90144-W, ISSN: 0014-4827.

Rifkind AB, Gannon M, Gross SS. Arachidonic acid metabolism by dioxin-induced cytochrome P-450: a new hypothesis on the role of P-450 in dioxin toxicity. Biochem. Biophys. Res. Commun. 1990 Nov 11/15/1990; 172(3): 1180-8. PMID: 2123101, PII: 0006-291X(90)91573-B, ISSN: 0006-291X.

Available Postdoctoral Position Details
Posted: 12/2/2016

Immediate postdoc position available to study the functional interactions between two pancreas transcription factors (Pdx1 and Oc1) in activating the endocrine differentiation program in multipotent pancreatic progenitors. Experience with mouse models helpful but not required. Please send CV and references to maureen.gannon@vanderbilt.edu.