David H. Wasserman, Ph.D.

Professor

david.wasserman@vanderbilt.edu

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Faculty Appointments
Director, Mouse Metabolic Phenotyping Center Professor of Molecular Physiology and Biophysics Annie Mary Lyle Chair
Education
Ph.D., Physiology, University of Toronto, TorontoM.Sc., Kinesiology, University of California, Los Angeles, CaliforniaB.Sc., Kinesiology, University of California, Los Angeles, California
Office Address
702 Light Hall
23rd Avenue at Pierce
Nashville, TN
Research Description
We use a variety of animal models, isotopic techniques and analytical methods that allow us to study metabolism from gene to the whole organism. In many of our studies we use physical exercise, insulin-stimulation or diet to perturb metabolic fuel systems. The research we undertake is not only critical to a basic understanding of fuel metabolism but also has important implications to diabetes and heart disease. Possible research projects include studies of:

a. site-specific (extracellular glucose delivery, glucose transport, glucose phosphorylation) regulation of muscle glucose uptake in normal physiology, in insulin resistant states induced by high fat feeding and in insulin sensitive states induced by physical exercise.

b. roles of insulin, glucagon, and glucagon-like peptides in regulation of hepatic glucose metabolism during and after exercise.

c. integrated control of glucose and fat metabolism in health and disease.

d. central role of AMP kinase in control of intra- and interorgan fuel fluxes.
Research Keywords
Exercise, Glucose, Amino Acids, Metabolism, Glucagon, Insulin, Catecholamines, Skeletal Muscle, Liver, Diabetes, Endocrinology, Mouse, Physiology, Fat, Long-chain fatty acids
Publications
Kang L, Mayes WH, James FD, Bracy DP, Wasserman DH. Matrix metalloproteinase 9 opposes diet-induced muscle insulin resistance in mice. Diabetologia [print-electronic]. 2014 Mar; 57(3): 603-13. PMID: 24305966, PMCID: PMC4155606, DOI: 10.1007/s00125-013-3128-1, ISSN: 1432-0428.

Hasenour CM, Ridley DE, Hughey CC, James FD, Donahue EP, Shearer J, Viollet B, Foretz M, Wasserman DH. 5-Aminoimidazole-4-carboxamide-1-ß-D-ribofuranoside (AICAR) effect on glucose production, but not energy metabolism, is independent of hepatic AMPK in vivo. J. Biol. Chem [print-electronic]. 2014 Feb 2/28/2014; 289(9): 5950-9. PMID: 24403081, PMCID: PMC3937663, PII: M113.528232, DOI: 10.1074/jbc.M113.528232, ISSN: 1083-351X.

Hughey CC, James FD, Ma L, Bracy DP, Wang Z, Wasserman DH, Rottman JN, Shearer J. Diminishing impairments in glucose uptake, mitochondrial content, and ADP-stimulated oxygen flux by mesenchymal stem cell therapy in the infarcted heart. Am. J. Physiol., Cell Physiol [print-electronic]. 2014 Jan 1/1/2014; 306(1): C19-27. PMID: 24196528, PMCID: PMC3919976, PII: ajpcell.00156.2013, DOI: 10.1152/ajpcell.00156.2013, ISSN: 1522-1563.

von Wilamowitz-Moellendorff A, Hunter RW, García-Rocha M, Kang L, López-Soldado I, Lantier L, Patel K, Peggie MW, Martínez-Pons C, Voss M, Calbó J, Cohen PT, Wasserman DH, Guinovart JJ, Sakamoto K. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis. Diabetes [print-electronic]. 2013 Dec; 62(12): 4070-82. PMID: 23990365, PMCID: PMC3837029, PII: db13-0880, DOI: 10.2337/db13-0880, ISSN: 1939-327X.

Morton GJ, Matsen ME, Bracy DP, Meek TH, Nguyen HT, Stefanovski D, Bergman RN, Wasserman DH, Schwartz MW. FGF19 action in the brain induces insulin-independent glucose lowering. J. Clin. Invest. 2013 Nov; 123(11): 4799-808. PMID: 24084738, PMCID: PMC3809800, PII: 70710, DOI: 10.1172/JCI70710, ISSN: 1558-8238.

Fessel JP, Flynn CR, Robinson LJ, Penner NL, Gladson S, Kang CJ, Wasserman DH, Hemnes AR, West JD. Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension. Am. J. Respir. Cell Mol. Biol. 2013 Nov; 49(5): 778-87. PMID: 23742019, PMCID: PMC3931097, DOI: 10.1165/rcmb.2012-0463OC, ISSN: 1535-4989.

Bonner JS, Lantier L, Hocking KM, Kang L, Owolabi M, James FD, Bracy DP, Brophy CM, Wasserman DH. Relaxin treatment reverses insulin resistance in mice fed a high-fat diet. Diabetes [print-electronic]. 2013 Sep; 62(9): 3251-60. PMID: 23801576, PMCID: PMC3749347, PII: db13-0033, DOI: 10.2337/db13-0033, ISSN: 1939-327X.

Kang L, Lantier L, Kennedy A, Bonner JS, Mayes WH, Bracy DP, Bookbinder LH, Hasty AH, Thompson CB, Wasserman DH. Hyaluronan accumulates with high-fat feeding and contributes to insulin resistance. Diabetes [print-electronic]. 2013 Jun; 62(6): 1888-96. PMID: 23349492, PMCID: PMC3661617, PII: db12-1502, DOI: 10.2337/db12-1502, ISSN: 1939-327X.

Shi SQ, Ansari TS, McGuinness OP, Wasserman DH, Johnson CH. Circadian disruption leads to insulin resistance and obesity. Curr. Biol [print-electronic]. 2013 Mar 3/4/2013; 23(5): 372-81. PMID: 23434278, PMCID: PMC3595381, PII: S0960-9822(13)00083-3, DOI: 10.1016/j.cub.2013.01.048, ISSN: 1879-0445.

Lee-Young RS, Bonner JS, Mayes WH, Iwueke I, Barrick BA, Hasenour CM, Kang L, Wasserman DH. AMP-activated protein kinase (AMPK)a2 plays a role in determining the cellular fate of glucose in insulin-resistant mouse skeletal muscle. Diabetologia [print-electronic]. 2013 Mar; 56(3): 608-17. PMID: 23224579, PMCID: PMC4075509, DOI: 10.1007/s00125-012-2787-7, ISSN: 1432-0428.

Hasenour CM, Berglund ED, Wasserman DH. Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver. Mol. Cell. Endocrinol [print-electronic]. 2013 Feb 2/25/2013; 366(2): 152-62. PMID: 22796337, PMCID: PMC3538936, PII: S0303-7207(12)00332-2, DOI: 10.1016/j.mce.2012.06.018, ISSN: 1872-8057.

Bonner JS, Lantier L, Hasenour CM, James FD, Bracy DP, Wasserman DH. Muscle-specific vascular endothelial growth factor deletion induces muscle capillary rarefaction creating muscle insulin resistance. Diabetes [print-electronic]. 2013 Feb; 62(2): 572-80. PMID: 23002035, PMCID: PMC3554359, PII: db12-0354, DOI: 10.2337/db12-0354, ISSN: 1939-327X.

Wang HY, Ducommun S, Quan C, Xie B, Li M, Wasserman DH, Sakamoto K, Mackintosh C, Chen S. AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. Biochem. J. 2013 Jan 1/15/2013; 449(2): 479-89. PMID: 23078342, PMCID: PMC3685216, PII: BJ20120702, DOI: 10.1042/BJ20120702, ISSN: 1470-8728.

Hughey CC, Ma L, James FD, Bracy DP, Wang Z, Wasserman DH, Rottman JN, Hittel DS, Shearer J. Mesenchymal stem cell transplantation for the infarcted heart: therapeutic potential for insulin resistance beyond the heart. Cardiovasc Diabetol. 2013; 12: 128. PMID: 24007410, PMCID: PMC3847505, PII: 1475-2840-12-128, DOI: 10.1186/1475-2840-12-128, ISSN: 1475-2840.

Drake KJ, Sidorov VY, McGuinness OP, Wasserman DH, Wikswo JP. Amino acids as metabolic substrates during cardiac ischemia. Exp. Biol. Med. (Maywood). 2012 Dec; 237(12): 1369-78. PMID: 23354395, PMCID: PMC3816490, PII: 237/12/1369, DOI: 10.1258/ebm.2012.012025, ISSN: 1535-3699.

Orr JS, Puglisi MJ, Ellacott KL, Lumeng CN, Wasserman DH, Hasty AH. Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages. Diabetes [print-electronic]. 2012 Nov; 61(11): 2718-27. PMID: 22751700, PMCID: PMC3478520, PII: db11-1595, DOI: 10.2337/db11-1595, ISSN: 1939-327X.

Kang L, Lustig ME, Bonner JS, Lee-Young RS, Mayes WH, James FD, Lin CT, Perry CG, Anderson EJ, Neufer PD, Wasserman DH. Mitochondrial antioxidative capacity regulates muscle glucose uptake in the conscious mouse: effect of exercise and diet. J. Appl. Physiol [print-electronic]. 2012 Oct 10/15/2012; 113(8): 1173-83. PMID: 22653994, PMCID: PMC3472490, PII: japplphysiol.01344.2011, DOI: 10.1152/japplphysiol.01344.2011, ISSN: 1522-1601.

Burmeister MA, Bracy DP, James FD, Holt RM, Ayala J, King EM, Wasserman DH, Drucker DJ, Ayala JE. Regulation of glucose kinetics during exercise by the glucagon-like peptide-1 receptor. J. Physiol. (Lond.) [print-electronic]. 2012 Oct 10/15/2012; 590(Pt 20): 5245-55. PMID: 22890715, PMCID: PMC3497575, PII: jphysiol.2012.234914, DOI: 10.1113/jphysiol.2012.234914, ISSN: 1469-7793.

Laughlin MR, Lloyd KC, Cline GW, Wasserman DH, . NIH Mouse Metabolic Phenotyping Centers: the power of centralized phenotyping. Mamm. Genome [print-electronic]. 2012 Oct; 23(9-10): 623-31. PMID: 22940748, PMCID: PMC3738176, DOI: 10.1007/s00335-012-9425-z, ISSN: 1432-1777.

Wu L, Parekh VV, Gabriel CL, Bracy DP, Marks-Shulman PA, Tamboli RA, Kim S, Mendez-Fernandez YV, Besra GS, Lomenick JP, Williams B, Wasserman DH, Van Kaer L. Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2012 May 5/8/2012; 109(19): E1143-52. PMID: 22493234, PMCID: PMC3358828, PII: 1200498109, DOI: 10.1073/pnas.1200498109, ISSN: 1091-6490.

Berglund ED, Li CY, Ayala JE, McGuinness OP, Wasserman DH. Regulation of endogenous glucose production in glucose transporter 4 over-expressing mice. PLoS ONE [print-electronic]. 2012; 7(12): e52355. PMID: 23285006, PMCID: PMC3524103, PII: PONE-D-12-27582, DOI: 10.1371/journal.pone.0052355, ISSN: 1932-6203.

Mulligan KX, Morris RT, Otero YF, Wasserman DH, McGuinness OP. Disassociation of muscle insulin signaling and insulin-stimulated glucose uptake during endotoxemia. PLoS ONE [print-electronic]. 2012; 7(1): e30160. PMID: 22276152, PMCID: PMC3262801, PII: PONE-D-11-12927, DOI: 10.1371/journal.pone.0030160, ISSN: 1932-6203.

Fletcher SJ, Kalupahana NS, Soltani-Bejnood M, Kim JH, Saxton AM, Wasserman DH, De Taeye B, Voy BH, Quignard-Boulange A, Moustaid-Moussa N. Transgenic mice overexpressing Renin exhibit glucose intolerance and diet-genotype interactions. Front Endocrinol (Lausanne). 2012; 3: 166. PMID: 23308073, PMCID: PMC3538348, DOI: 10.3389/fendo.2012.00166, ISSN: 1664-2392.

Berglund ED, Lustig DG, Baheza RA, Hasenour CM, Lee-Young RS, Donahue EP, Lynes SE, Swift LL, Charron MJ, Damon BM, Wasserman DH. Hepatic glucagon action is essential for exercise-induced reversal of mouse fatty liver. Diabetes [print-electronic]. 2011 Nov; 60(11): 2720-9. PMID: 21885872, PMCID: PMC3198076, PII: db11-0455, DOI: 10.2337/db11-0455, ISSN: 1939-327X.

Luther JM, Luo P, Kreger MT, Brissova M, Dai C, Whitfield TT, Kim HS, Wasserman DH, Powers AC, Brown NJ. Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets. Diabetologia [print-electronic]. 2011 Aug; 54(8): 2152-63. PMID: 21519965, PMCID: PMC3216479, DOI: 10.1007/s00125-011-2158-9, ISSN: 1432-0428.

Lee-Young RS, Ayala JE, Fueger PT, Mayes WH, Kang L, Wasserman DH. Obesity impairs skeletal muscle AMPK signaling during exercise: role of AMPKa2 in the regulation of exercise capacity in vivo. Int J Obes (Lond) [print-electronic]. 2011 Jul; 35(7): 982-9. PMID: 21079619, PMCID: PMC3049903, PII: ijo2010220, DOI: 10.1038/ijo.2010.220, ISSN: 1476-5497.

Yin DP, Gao Q, Ma LL, Yan W, Williams PE, McGuinness OP, Wasserman DH, Abumrad NN. Assessment of different bariatric surgeries in the treatment of obesity and insulin resistance in mice. Ann. Surg. 2011 Jul; 254(1): 73-82. PMID: 21522012, PMCID: PMC3115424, DOI: 10.1097/SLA.0b013e3182197035, ISSN: 1528-1140.

Wullschleger S, Wasserman DH, Gray A, Sakamoto K, Alessi DR. Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis. Biochem. J. 2011 Mar 3/1/2011; 434(2): 265-74. PMID: 21204784, PMCID: PMC4461655, PII: BJ20102012, DOI: 10.1042/BJ20102012, ISSN: 1470-8728.

Kang L, Ayala JE, Lee-Young RS, Zhang Z, James FD, Neufer PD, Pozzi A, Zutter MM, Wasserman DH. Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice. Diabetes. 2011 Feb; 60(2): 416-26. PMID: 21270253, PMCID: PMC3028340, PII: 60/2/416, DOI: 10.2337/db10-1116, ISSN: 1939-327X.

Wasserman DH, Kang L, Ayala JE, Fueger PT, Lee-Young RS. The physiological regulation of glucose flux into muscle in vivo. J. Exp. Biol. 2011 Jan 1/15/2011; 214(Pt 2): 254-62. PMID: 21177945, PMCID: PMC3008632, PII: 214/2/254, DOI: 10.1242/jeb.048041, ISSN: 1477-9145.

Chen S, Wasserman DH, MacKintosh C, Sakamoto K. Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking. Cell Metab. 2011 Jan 1/5/2011; 13(1): 68-79. PMID: 21195350, PMCID: PMC3081066, PII: S1550-4131(10)00447-X, DOI: 10.1016/j.cmet.2010.12.005, ISSN: 1932-7420.

Ayala JE, Bracy DP, Malabanan C, James FD, Ansari T, Fueger PT, McGuinness OP, Wasserman DH. Hyperinsulinemic-euglycemic clamps in conscious, unrestrained mice. J Vis Exp. 2011; (57): PMID: 22126863, PMCID: PMC3308587, PII: 3188, DOI: 10.3791/3188, ISSN: 1940-087X.

Ayala JE, Bracy DP, James FD, Burmeister MA, Wasserman DH, Drucker DJ. Glucagon-like peptide-1 receptor knockout mice are protected from high-fat diet-induced insulin resistance. Endocrinology [print-electronic]. 2010 Oct; 151(10): 4678-87. PMID: 20685876, PMCID: PMC2946144, PII: en.2010-0289, DOI: 10.1210/en.2010-0289, ISSN: 1945-7170.

Berglund ED, Kang L, Lee-Young RS, Hasenour CM, Lustig DG, Lynes SE, Donahue EP, Swift LL, Charron MJ, Wasserman DH. Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARalpha and FGF21 transcripts in vivo. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2010 Oct; 299(4): E607-14. PMID: 20663988, PMCID: PMC2957865, PII: ajpendo.00263.2010, DOI: 10.1152/ajpendo.00263.2010, ISSN: 1522-1555.

Ayala JE, Samuel VT, Morton GJ, Obici S, Croniger CM, Shulman GI, Wasserman DH, McGuinness OP, . Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Dis Model Mech [print-electronic]. 2010 Sep; 3(9-10): 525-34. PMID: 20713647, PMCID: PMC2938392, PII: dmm.006239, DOI: 10.1242/dmm.006239, ISSN: 1754-8411.

Lee-Young RS, Ayala JE, Hunley CF, James FD, Bracy DP, Kang L, Wasserman DH. Endothelial nitric oxide synthase is central to skeletal muscle metabolic regulation and enzymatic signaling during exercise in vivo. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2010 May; 298(5): R1399-408. PMID: 20200137, PMCID: PMC2867517, PII: 00004.2010, DOI: 10.1152/ajpregu.00004.2010, ISSN: 1522-1490.

Shi S, Hida A, McGuinness OP, Wasserman DH, Yamazaki S, Johnson CH. Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2. Curr. Biol [print-electronic]. 2010 Feb 2/23/2010; 20(4): 316-21. PMID: 20153195, PMCID: PMC2907674, PII: S0960-9822(09)02158-7, DOI: 10.1016/j.cub.2009.12.034, ISSN: 1879-0445.

McGuinness OP, Ayala JE, Laughlin MR, Wasserman DH. NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2009 Oct; 297(4): E849-55. PMID: 19638507, PMCID: PMC2763792, PII: 90996.2008, DOI: 10.1152/ajpendo.90996.2008, ISSN: 1522-1555.

Lee-Young RS, Griffee SR, Lynes SE, Bracy DP, Ayala JE, McGuinness OP, Wasserman DH. Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo. J. Biol. Chem [print-electronic]. 2009 Sep 9/4/2009; 284(36): 23925-34. PMID: 19525228, PMCID: PMC2781986, PII: M109.021048, DOI: 10.1074/jbc.M109.021048, ISSN: 0021-9258.

Wasserman DH, Ayala JE, McGuinness OP. Lost in translation. Diabetes. 2009 Sep; 58(9): 1947-50. PMID: 19720822, PMCID: PMC2731517, PII: 58/9/1947, DOI: 10.2337/db09-0537, ISSN: 1939-327X.

Berglund ED, Li CY, Bina HA, Lynes SE, Michael MD, Shanafelt AB, Kharitonenkov A, Wasserman DH. Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity. Endocrinology [print-electronic]. 2009 Sep; 150(9): 4084-93. PMID: 19470704, PMCID: PMC2736088, PII: en.2009-0221, DOI: 10.1210/en.2009-0221, ISSN: 1945-7170.

Berglund ED, Lee-Young RS, Lustig DG, Lynes SE, Donahue EP, Camacho RC, Meredith ME, Magnuson MA, Charron MJ, Wasserman DH. Hepatic energy state is regulated by glucagon receptor signaling in mice. J. Clin. Invest. 2009 Aug; 119(8): 2412-22. PMID: 19662685, PMCID: PMC2719934, ISSN: 1558-8238.

Ayala JE, Bracy DP, James FD, Julien BM, Wasserman DH, Drucker DJ. The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action. Endocrinology [print-electronic]. 2009 Mar; 150(3): 1155-64. PMID: 19008308, PMCID: PMC2654733, PII: en.2008-0945, DOI: 10.1210/en.2008-0945, ISSN: 1945-7170.

Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin CT, Price JW, Kang L, Rabinovitch PS, Szeto HH, Houmard JA, Cortright RN, Wasserman DH, Neufer PD. Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J. Clin. Invest [print-electronic]. 2009 Mar; 119(3): 573-81. PMID: 19188683, PMCID: PMC2648700, PII: 37048, DOI: 10.1172/JCI37048, ISSN: 1558-8238.

Coenen KR, Gruen ML, Lee-Young RS, Puglisi MJ, Wasserman DH, Hasty AH. Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice. Diabetologia [print-electronic]. 2009 Feb; 52(2): 318-28. PMID: 19052722, PMCID: PMC2615827, DOI: 10.1007/s00125-008-1221-7, ISSN: 1432-0428.

Wasserman DH. Four grams of glucose. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2009 Jan; 296(1): E11-21. PMID: 18840763, PMCID: PMC2636990, PII: 90563.2008, DOI: 10.1152/ajpendo.90563.2008, ISSN: 0193-1849.

Han BG, Hao CM, Tchekneva EE, Wang YY, Lee CA, Ebrahim B, Harris RC, Kern TS, Wasserman DH, Breyer MD, Qi Z. Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb A1c. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2008 Oct; 295(4): E981-6. PMID: 18664598, PMCID: PMC2575908, PII: 90283.2008, DOI: 10.1152/ajpendo.90283.2008, ISSN: 0193-1849.

Shearer J, Fueger PT, Wang Z, Bracy DP, Wasserman DH, Rottman JN. Metabolic implications of reduced heart-type fatty acid binding protein in insulin resistant cardiac muscle. Biochim. Biophys. Acta [print-electronic]. 2008 Oct; 1782(10): 586-92. PMID: 18692568, PII: S0925-4439(08)00136-1, DOI: 10.1016/j.bbadis.2008.07.003, ISSN: 0006-3002.

Shearer J, Duggan G, Weljie A, Hittel DS, Wasserman DH, Vogel HJ. Metabolomic profiling of dietary-induced insulin resistance in the high fat-fed C57BL/6J mouse. Diabetes Obes Metab [print-electronic]. 2008 Sep; 10(10): 950-8. PMID: 18215169, PII: DOM837, DOI: 10.1111/j.1463-1326.2007.00837.x, ISSN: 1463-1326.

Shearer J, Coenen KR, Pencek RR, Swift LL, Wasserman DH, Rottman JN. Long chain fatty acid uptake in vivo: comparison of [125I]-BMIPP and [3H]-bromopalmitate. Lipids [print-electronic]. 2008 Aug; 43(8): 703-11. PMID: 18481132, DOI: 10.1007/s11745-008-3183-4, ISSN: 0024-4201.

Berglund ED, Li CY, Poffenberger G, Ayala JE, Fueger PT, Willis SE, Jewell MM, Powers AC, Wasserman DH. Glucose metabolism in vivo in four commonly used inbred mouse strains. Diabetes [print-electronic]. 2008 Jul; 57(7): 1790-9. PMID: 18398139, PMCID: PMC2453626, PII: db07-1615, DOI: 10.2337/db07-1615, ISSN: 1939-327X.

Ayala JE, Bracy DP, Hansotia T, Flock G, Seino Y, Wasserman DH, Drucker DJ. Insulin action in the double incretin receptor knockout mouse. Diabetes [print-electronic]. 2008 Feb; 57(2): 288-97. PMID: 17977951, PII: db07-0704, DOI: 10.2337/db07-0704, ISSN: 1939-327X.

Fueger PT, Lee-Young RS, Shearer J, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH. Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase II. Diabetes [print-electronic]. 2007 Oct; 56(10): 2476-84. PMID: 17639019, PII: db07-0532, DOI: 10.2337/db07-0532, ISSN: 1939-327X.

Shearer J, Sellars EA, Farah A, Graham TE, Wasserman DH. Effects of chronic coffee consumption on glucose kinetics in the conscious rat. Can. J. Physiol. Pharmacol. 2007 Aug; 85(8): 823-30. PMID: 17901893, PII: y07-070, DOI: 10.1139/y07-070, ISSN: 0008-4212.

Fueger PT, Li CY, Ayala JE, Shearer J, Bracy DP, Charron MJ, Rottman JN, Wasserman DH. Glucose kinetics and exercise tolerance in mice lacking the GLUT4 glucose transporter. J. Physiol. (Lond.) [print-electronic]. 2007 Jul 7/15/2007; 582(Pt 2): 801-12. PMID: 17495042, PMCID: PMC2075340, PII: jphysiol.2007.132902, DOI: 10.1113/jphysiol.2007.132902, ISSN: 0022-3751.

Ayala JE, Bracy DP, Julien BM, Rottman JN, Fueger PT, Wasserman DH. Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice. Diabetes [print-electronic]. 2007 Apr; 56(4): 1025-33. PMID: 17229936, PII: db06-0883, DOI: 10.2337/db06-0883, ISSN: 0012-1797.

Rao R, Hao CM, Redha R, Wasserman DH, McGuinness OP, Breyer MD. Glycogen synthase kinase 3 inhibition improves insulin-stimulated glucose metabolism but not hypertension in high-fat-fed C57BL/6J mice. Diabetologia [print-electronic]. 2007 Feb; 50(2): 452-60. PMID: 17151860, DOI: 10.1007/s00125-006-0552-5, ISSN: 0012-186X.

Wasserman DH, Fueger PT. Point-Counterpoint: Glucose phosphorylation is/is not a significant barrier to muscle glucose uptake by the working muscle. J. Appl. Physiol. 2006 Dec; 101(6): 1803-5. PMID: 17106068, PII: 101/6/1803, DOI: 10.1152/japplphysiol.00817a.2006, ISSN: 8750-7587.

Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C, White RD. Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes Care. 2006 Jun; 29(6): 1433-8. PMID: 16732040, PII: 29/6/1433, DOI: 10.2337/dc06-9910, ISSN: 0149-5992.

Camacho RC, Donahue EP, James FD, Berglund ED, Wasserman DH. Energy state of the liver during short-term and exhaustive exercise in C57BL/6J mice. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2006 Mar; 290(3): E405-8. PMID: 16219665, PII: 00385.2005, DOI: 10.1152/ajpendo.00385.2005, ISSN: 0193-1849.

Nunemaker CS, Wasserman DH, McGuinness OP, Sweet IR, Teague JC, Satin LS. Insulin secretion in the conscious mouse is biphasic and pulsatile. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2006 Mar; 290(3): E523-9. PMID: 16249252, PII: 00392.2005, DOI: 10.1152/ajpendo.00392.2005, ISSN: 0193-1849.

Ayala JE, Bracy DP, McGuinness OP, Wasserman DH. Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse. Diabetes. 2006 Feb; 55(2): 390-7. PMID: 16443772, PII: 55/2/390, ISSN: 0012-1797.

Liang X, Kanjanabuch T, Mao SL, Hao CM, Tang YW, Declerck PJ, Hasty AH, Wasserman DH, Fogo AB, Ma LJ. Plasminogen activator inhibitor-1 modulates adipocyte differentiation. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2006 Jan; 290(1): E103-E113. PMID: 16144810, PII: 00605.2004, DOI: 10.1152/ajpendo.00605.2004, ISSN: 0193-1849.

Camacho RC, Lacy DB, James FD, Donahue EP, Wasserman DH. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside renders glucose output by the liver of the dog insensitive to a pharmacological increment in insulin. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2005 Dec; 289(6): E1039-43. PMID: 16046457, PII: 00247.2005, DOI: 10.1152/ajpendo.00247.2005, ISSN: 0193-1849.

Nunemaker CS, Zhang M, Wasserman DH, McGuinness OP, Powers AC, Bertram R, Sherman A, Satin LS. Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo?. Diabetes. 2005 Dec; 54(12): 3517-22. PMID: 16306370, PII: 54/12/3517, ISSN: 0012-1797.

Shearer J, Fueger PT, Bracy DP, Wasserman DH, Rottman JN. Partial gene deletion of heart-type fatty acid-binding protein limits the severity of dietary-induced insulin resistance. Diabetes. 2005 Nov; 54(11): 3133-9. PMID: 16249436, PII: 54/11/3133, ISSN: 0012-1797.

Fueger PT, Shearer J, Krueger TM, Posey KA, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH. Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse. J. Physiol. (Lond.) [print-electronic]. 2005 Jul 7/15/2005; 566(Pt 2): 533-41. PMID: 15878951, PMCID: PMC1464755, PII: jphysiol.2005.085043, DOI: 10.1113/jphysiol.2005.085043, ISSN: 0022-3751.

Pencek RR, Fueger PT, Camacho RC, Wasserman DH. Mobilization of glucose from the liver during exercise and replenishment afterward. Can J Appl Physiol. 2005 Jun; 30(3): 292-303. PMID: 16129894, ISSN: 1066-7814.

Wasserman DH, Ayala JE. Interaction of physiological mechanisms in control of muscle glucose uptake. Clin. Exp. Pharmacol. Physiol. 2005 Apr; 32(4): 319-23. PMID: 15810999, PII: CEP4191, DOI: 10.1111/j.1440-1681.2005.04191.x, ISSN: 0305-1870.

Shearer J, Fueger PT, Rottman JN, Bracy DP, Binas B, Wasserman DH. Heart-type fatty acid-binding protein reciprocally regulates glucose and fatty acid utilization during exercise. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2005 Feb; 288(2): E292-7. PMID: 15454399, PII: 00287.2004, DOI: 10.1152/ajpendo.00287.2004, ISSN: 0193-1849.

Camacho RC, Pencek RR, Lacy DB, James FD, Donahue EP, Wasserman DH. Portal venous 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion overcomes hyperinsulinemic suppression of endogenous glucose output. Diabetes. 2005 Feb; 54(2): 373-82. PMID: 15677495, PII: 54/2/373, ISSN: 0012-1797.

Pencek RR, Shearer J, Camacho RC, James FD, Lacy DB, Fueger PT, Donahue EP, Snead W, Wasserman DH. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivo. Diabetes. 2005 Feb; 54(2): 355-60. PMID: 15677492, PII: 54/2/355, ISSN: 0012-1797.

Fueger PT, Shearer J, Bracy DP, Posey KA, Pencek RR, McGuinness OP, Wasserman DH. Control of muscle glucose uptake: test of the rate-limiting step paradigm in conscious, unrestrained mice. J. Physiol. (Lond.) [print-electronic]. 2005 Feb 2/1/2005; 562(Pt 3): 925-35. PMID: 15576451, PMCID: PMC1665542, PII: jphysiol.2004.076158, DOI: 10.1113/jphysiol.2004.076158, ISSN: 0022-3751.

Camacho RC, Galassetti P, Davis SN, Wasserman DH. Glucoregulation during and after exercise in health and insulin-dependent diabetes. Exerc Sport Sci Rev. 2005 Jan; 33(1): 17-23. PMID: 15640716, PII: 00003677-200501000-00004, ISSN: 0091-6331.

Fueger PT, Hess HS, Posey KA, Bracy DP, Pencek RR, Charron MJ, Wasserman DH. Control of exercise-stimulated muscle glucose uptake by GLUT4 is dependent on glucose phosphorylation capacity in the conscious mouse. J. Biol. Chem [print-electronic]. 2004 Dec 12/3/2004; 279(49): 50956-61. PMID: 15456776, PII: M408312200, DOI: 10.1074/jbc.M408312200, ISSN: 0021-9258.

Pencek RR, James FD, Lacy DB, Jabbour K, Williams PE, Fueger PT, Wasserman DH. Exercise-induced changes in insulin and glucagon are not required for enhanced hepatic glucose uptake after exercise but influence the fate of glucose within the liver. Diabetes. 2004 Dec; 53(12): 3041-7. PMID: 15561932, PII: 53/12/3041, ISSN: 0012-1797.

Shearer J, Fueger PT, Rottman JN, Bracy DP, Martin PH, Wasserman DH. AMPK stimulation increases LCFA but not glucose clearance in cardiac muscle in vivo. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Nov; 287(5): E871-7. PMID: 15265760, PII: 00125.2004, DOI: 10.1152/ajpendo.00125.2004, ISSN: 0193-1849.

Pencek RR, Battram D, Shearer J, James FD, Lacy DB, Jabbour K, Williams PE, Graham TE, Wasserman DH. Portal vein caffeine infusion enhances net hepatic glucose uptake during a glucose load in conscious dogs. J. Nutr. 2004 Nov; 134(11): 3042-6. PMID: 15514273, PII: 134/11/3042, ISSN: 0022-3166.

Fueger PT, Hess HS, Bracy DP, Pencek RR, Posey KA, Charron MJ, Wasserman DH. Regulation of insulin-stimulated muscle glucose uptake in the conscious mouse: role of glucose transport is dependent on glucose phosphorylation capacity. Endocrinology [print-electronic]. 2004 Nov; 145(11): 4912-6. PMID: 15284204, PII: en.2004-0465, DOI: 10.1210/en.2004-0465, ISSN: 0013-7227.

Bederman IR, Reszko AE, Kasumov T, David F, Wasserman DH, Kelleher JK, Brunengraber H. Zonation of labeling of lipogenic acetyl-CoA across the liver: implications for studies of lipogenesis by mass isotopomer analysis. J. Biol. Chem [print-electronic]. 2004 Oct 10/8/2004; 279(41): 43207-16. PMID: 15284242, PII: M403838200, DOI: 10.1074/jbc.M403838200, ISSN: 0021-9258.

Camacho RC, Denny JC, Pencek RR, Koyama Y, Lacy DB, James FD, Wasserman DH. Portal venous hyperinsulinemia does not stimulate gut glucose absorption in the conscious dog. Metab. Clin. Exp. 2004 Oct; 53(10): 1290-5. PMID: 15375784, PII: S0026049504002343, ISSN: 0026-0495.

Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C. Physical activity/exercise and type 2 diabetes. Diabetes Care. 2004 Oct; 27(10): 2518-39. PMID: 15451933, PII: 27/10/2518, ISSN: 0149-5992.

Camacho RC, Lacy DB, James FD, Coker RH, Wasserman DH. Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Aug; 287(2): E269-74. PMID: 15053988, PII: 00040.2004, DOI: 10.1152/ajpendo.00040.2004, ISSN: 0193-1849.

Galassetti P, Tate D, Neill RA, Morrey S, Wasserman DH, Davis SN. Effect of sex on counterregulatory responses to exercise after antecedent hypoglycemia in type 1 diabetes. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Jul; 287(1): E16-24. PMID: 14998785, PII: 00480.2002, DOI: 10.1152/ajpendo.00480.2002, ISSN: 0193-1849.

Shearer J, Fueger PT, Vorndick B, Bracy DP, Rottman JN, Clanton JA, Wasserman DH. AMP kinase-induced skeletal muscle glucose but not long-chain fatty acid uptake is dependent on nitric oxide. Diabetes. 2004 Jun; 53(6): 1429-35. PMID: 15161745, PII: 53/6/1429, ISSN: 0012-1797.

Ma LJ, Mao SL, Taylor KL, Kanjanabuch T, Guan Y, Zhang Y, Brown NJ, Swift LL, McGuinness OP, Wasserman DH, Vaughan DE, Fogo AB. Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes. 2004 Feb; 53(2): 336-46. PMID: 14747283, ISSN: 0012-1797.

Fueger PT, Bracy DP, Malabanan CM, Pencek RR, Granner DK, Wasserman DH. Hexokinase II overexpression improves exercise-stimulated but not insulin-stimulated muscle glucose uptake in high-fat-fed C57BL/6J mice. Diabetes. 2004 Feb; 53(2): 306-14. PMID: 14747279, ISSN: 0012-1797.

Camacho RC, Pencek RR, Lacy DB, James FD, Wasserman DH. Suppression of endogenous glucose production by mild hyperinsulinemia during exercise is determined predominantly by portal venous insulin. Diabetes. 2004 Feb; 53(2): 285-93. PMID: 14747277, ISSN: 0012-1797.

Fueger PT, Bracy DP, Malabanan CM, Pencek RR, Wasserman DH. Distributed control of glucose uptake by working muscles of conscious mice: roles of transport and phosphorylation. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Jan; 286(1): E77-84. PMID: 13129858, PII: 00309.2003, DOI: 10.1152/ajpendo.00309.2003, ISSN: 0193-1849.

Shearer J, Farah A, de Paulis T, Bracy DP, Pencek RR, Graham TE, Wasserman DH. Quinides of roasted coffee enhance insulin action in conscious rats. J. Nutr. 2003 Nov; 133(11): 3529-32. PMID: 14608069, ISSN: 0022-3166.

Fueger PT, Heikkinen S, Bracy DP, Malabanan CM, Pencek RR, Laakso M, Wasserman DH. Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2003 Nov; 285(5): E958-63. PMID: 12865258, PII: 00190.2003, DOI: 10.1152/ajpendo.00190.2003, ISSN: 0193-1849.

Moore MC, Cherrington AD, Wasserman DH. Regulation of hepatic and peripheral glucose disposal. Best Pract. Res. Clin. Endocrinol. Metab. 2003 Sep; 17(3): 343-64. PMID: 12962690, PII: S1521690X03000368, ISSN: 1521-690X.

Pencek RR, Koyama Y, Lacy DB, James FD, Fueger PT, Jabbour K, Williams PE, Wasserman DH. Prior exercise enhances passive absorption of intraduodenal glucose. J. Appl. Physiol [print-electronic]. 2003 Sep; 95(3): 1132-8. PMID: 12740315, PII: 01172.2002, DOI: 10.1152/japplphysiol.01172.2002, ISSN: 8750-7587.

Pencek RR, James F, Lacy DB, Jabbour K, Williams PE, Fueger PT, Wasserman DH. Interaction of insulin and prior exercise in control of hepatic metabolism of a glucose load. Diabetes. 2003 Aug; 52(8): 1897-903. PMID: 12882903, ISSN: 0012-1797.

Galassetti P, Tate D, Neill RA, Morrey S, Wasserman DH, Davis SN. Effect of antecedent hypoglycemia on counterregulatory responses to subsequent euglycemic exercise in type 1 diabetes. Diabetes. 2003 Jul; 52(7): 1761-9. PMID: 12829644, ISSN: 0012-1797.

Petersen HA, Fueger PT, Bracy DP, Wasserman DH, Halseth AE. Fiber type-specific determinants of Vmax for insulin-stimulated muscle glucose uptake in vivo. Am. J. Physiol. Endocrinol. Metab. 2003 Mar; 284(3): E541-8. PMID: 12556351, PII: 284/3/E541, DOI: 10.1152/ajpendo.00323.2002, ISSN: 0193-1849.

Pencek RR, Koyama Y, Lacy DB, James FD, Fueger PT, Jabbour K, Williams PE, Wasserman DH. Transporter-mediated absorption is the primary route of entry and is required for passive absorption of intestinal glucose into the blood of conscious dogs. J. Nutr. 2002 Jul; 132(7): 1929-34. PMID: 12097672, ISSN: 0022-3166.

Rottman JN, Bracy D, Malabanan C, Yue Z, Clanton J, Wasserman DH. Contrasting effects of exercise and NOS inhibition on tissue-specific fatty acid and glucose uptake in mice. Am. J. Physiol. Endocrinol. Metab. 2002 Jul; 283(1): E116-23. PMID: 12067851, DOI: 10.1152/ajpendo.00545.2001, ISSN: 0193-1849.

Coker RH, Koyama Y, Denny JC, Camacho RC, Lacy DB, Wasserman DH. Prevention of overt hypoglycemia during exercise: stimulation of endogenous glucose production independent of hepatic catecholamine action and changes in pancreatic hormone concentration. Diabetes. 2002 May; 51(5): 1310-8. PMID: 11978626, ISSN: 0012-1797.

Koyama Y, Galassetti P, Coker RH, Pencek RR, Lacy DB, Davis SN, Wasserman DH. Prior exercise and the response to insulin-induced hypoglycemia in the dog. Am. J. Physiol. Endocrinol. Metab. 2002 May; 282(5): E1128-38. PMID: 11934679, DOI: 10.1152/ajpendo.00370.2001, ISSN: 0193-1849.

Koyama Y, Coker RH, Denny JC, Lacy DB, Jabbour K, Williams PE, Wasserman DH. Role of carotid bodies in control of the neuroendocrine response to exercise. Am. J. Physiol. Endocrinol. Metab. 2001 Oct; 281(4): E742-8. PMID: 11551850, ISSN: 0193-1849.

Galassetti P, Neill AR, Tate D, Ertl AC, Wasserman DH, Davis SN. Sexual dimorphism in counterregulatory responses to hypoglycemia after antecedent exercise. J. Clin. Endocrinol. Metab. 2001 Aug; 86(8): 3516-24. PMID: 11502773, DOI: 10.1210/jcem.86.8.7720, ISSN: 0021-972X.

Galassetti P, Mann S, Tate D, Neill RA, Wasserman DH, Davis SN. Effect of morning exercise on counterregulatory responses to subsequent, afternoon exercise. J. Appl. Physiol. 2001 Jul; 91(1): 91-9. PMID: 11408418, ISSN: 8750-7587.

Halseth AE, Bracy DP, Wasserman DH. Functional limitations to glucose uptake in muscles comprised of different fiber types. Am. J. Physiol. Endocrinol. Metab. 2001 Jun; 280(6): E994-9. PMID: 11350781, ISSN: 0193-1849.

Galassetti P, Mann S, Tate D, Neill RA, Costa F, Wasserman DH, Davis SN. Effects of antecedent prolonged exercise on subsequent counterregulatory responses to hypoglycemia. Am. J. Physiol. Endocrinol. Metab. 2001 Jun; 280(6): E908-17. PMID: 11350772, ISSN: 0193-1849.

Coker RH, Simonsen L, Bülow J, Wasserman DH, Kjaer M. Stimulation of splanchnic glucose production during exercise in humans contains a glucagon-independent component. Am. J. Physiol. Endocrinol. Metab. 2001 Jun; 280(6): E918-27. PMID: 11350773, ISSN: 0193-1849.

Halseth AE, Bracy DP, Wasserman DH. Limitations to basal and insulin-stimulated skeletal muscle glucose uptake in the high-fat-fed rat. Am. J. Physiol. Endocrinol. Metab. 2000 Nov; 279(5): E1064-71. PMID: 11052961, ISSN: 0193-1849.

Koyama Y, Coker RH, Stone EE, Lacy DB, Jabbour K, Williams PE, Wasserman DH. Evidence that carotid bodies play an important role in glucoregulation in vivo. Diabetes. 2000 Sep; 49(9): 1434-42. PMID: 10969826, ISSN: 0012-1797.

Krishna MG, Coker RH, Lacy DB, Zinker BA, Halseth AE, Wasserman DH. Glucagon response to exercise is critical for accelerated hepatic glutamine metabolism and nitrogen disposal. Am. J. Physiol. Endocrinol. Metab. 2000 Sep; 279(3): E638-45. PMID: 10950833, ISSN: 0193-1849.

Coker RH, Lacy DB, Williams PE, Wasserman DH. Hepatic alpha- and beta-adrenergic receptors are not essential for the increase in R(a) during exercise in diabetes. Am. J. Physiol. Endocrinol. Metab. 2000 Mar; 278(3): E444-51. PMID: 10710498, ISSN: 0193-1849.

Halseth AE, O'Doherty RM, Printz RL, Bracy DP, Granner DK, Wasserman DH. Role of Ca(2+) fluctuations in L6 myotubes in the regulation of the hexokinase II gene. J. Appl. Physiol. 2000 Feb; 88(2): 669-73. PMID: 10658036, ISSN: 8750-7587.

Davis SN, Galassetti P, Wasserman DH, Tate D. Effects of gender on neuroendocrine and metabolic counterregulatory responses to exercise in normal man. J. Clin. Endocrinol. Metab. 2000 Jan; 85(1): 224-30. PMID: 10634391, DOI: 10.1210/jcem.85.1.6328, ISSN: 0021-972X.

Davis SN, Galassetti P, Wasserman DH, Tate D. Effects of antecedent hypoglycemia on subsequent counterregulatory responses to exercise. Diabetes. 2000 Jan; 49(1): 73-81. PMID: 10615952, ISSN: 0012-1797.

Coker RH, Koyama Y, Lacy DB, Williams PE, Rhèaume N, Wasserman DH. Pancreatic innervation is not essential for exercise-induced changes in glucagon and insulin or glucose kinetics. Am. J. Physiol. 1999 Dec; 277(6 Pt 1): E1122-9. PMID: 10600803, ISSN: 0002-9513.

Galassetti P, Koyama Y, Coker RH, Lacy DB, Cherrington AD, Wasserman DH. Role of a negative arterial-portal venous glucose gradient in the postexercise state. Am. J. Physiol. 1999 Dec; 277(6 Pt 1): E1038-45. PMID: 10600793, ISSN: 0002-9513.

Puchowicz MA, Bederman IR, Comte B, Yang D, David F, Stone E, Jabbour K, Wasserman DH, Brunengraber H. Zonation of acetate labeling across the liver: implications for studies of lipogenesis by MIDA. Am. J. Physiol. 1999 Dec; 277(6 Pt 1): E1022-7. PMID: 10600790, ISSN: 0002-9513.

Galassetti P, Chu CA, Neal DW, Reed GW, Wasserman DH, Cherrington AD. A negative arterial-portal venous glucose gradient increases net hepatic glucose uptake in euglycemic dogs. Am. J. Physiol. 1999 Jul; 277(1 Pt 1): E126-34. PMID: 10409136, ISSN: 0002-9513.

Galassetti P, Coker RH, Lacy DB, Cherrington AD, Wasserman DH. Prior exercise increases net hepatic glucose uptake during a glucose load. Am. J. Physiol. 1999 Jun; 276(6 Pt 1): E1022-9. PMID: 10362614, ISSN: 0002-9513.

Coker RH, Lacy DB, Krishna MG, Wasserman DH. Splanchnic glucagon kinetics in exercising alloxan-diabetic dogs. J. Appl. Physiol. 1999 May; 86(5): 1626-31. PMID: 10233127, ISSN: 8750-7587.

Galassetti P, Hamilton KS, Gibbons FK, Bracy DP, Lacy DB, Cherrington AD, Wasserman DH. Effect of fast duration on disposition of an intraduodenal glucose load in the conscious dog. Am. J. Physiol. 1999 Mar; 276(3 Pt 1): E543-52. PMID: 10070022, ISSN: 0002-9513.

Halseth AE, Bracy DP, Wasserman DH. Overexpression of hexokinase II increases insulinand exercise-stimulated muscle glucose uptake in vivo. Am. J. Physiol. 1999 Jan; 276(1 Pt 1): E70-7. PMID: 9886952, ISSN: 0002-9513.

Halseth AE, Bracy DP, Wasserman DH. Limitations to exercise- and maximal insulin-stimulated muscle glucose uptake. J. Appl. Physiol. 1998 Dec; 85(6): 2305-13. PMID: 9843557, ISSN: 8750-7587.

Halseth AE, Rhéaume N, Messina AB, Reed EK, Krishna MG, Flakoll PJ, Lacy DB, Wasserman DH. Regulation of hepatic glutamine metabolism during exercise in the dog. Am. J. Physiol. 1998 Oct; 275(4 Pt 1): E655-64. PMID: 9755085, ISSN: 0002-9513.

Galassetti P, Shiota M, Zinker BA, Wasserman DH, Cherrington AD. A negative arterial-portal venous glucose gradient decreases skeletal muscle glucose uptake. Am. J. Physiol. 1998 Jul; 275(1 Pt 1): E101-11. PMID: 9688880, ISSN: 0002-9513.

Galassetti P, Gibbons FK, Hamilton KS, Lacy DB, Cherrington AD, Wasserman DH. Enhanced muscle glucose uptake facilitates nitrogen efflux from exercised muscle. J. Appl. Physiol. 1998 Jun; 84(6): 1952-9. PMID: 9609789, ISSN: 8750-7587.

O'Doherty RM, Halseth AE, Granner DK, Bracy DP, Wasserman DH. Analysis of insulin-stimulated skeletal muscle glucose uptake in conscious rat using isotopic glucose analogs. Am. J. Physiol. 1998 Feb; 274(2 Pt 1): E287-96. PMID: 9486160, ISSN: 0002-9513.

Wasserman DH, Halseth AE. An overview of muscle glucose uptake during exercise. Sites of regulation. Adv. Exp. Med. Biol. 1998; 441: 1-16. PMID: 9781309, ISSN: 0065-2598.

Halseth AE, Flakoll PJ, Reed EK, Messina AB, Krishna MG, Lacy DB, Williams PE, Wasserman DH. Effect of physical activity and fasting on gut and liver proteolysis in the dog. Am. J. Physiol. 1997 Dec; 273(6 Pt 1): E1073-82. PMID: 9435521, ISSN: 0002-9513.

Coker RH, Krishna MG, Lacy DB, Bracy DP, Wasserman DH. Role of hepatic alpha- and beta-adrenergic receptor stimulation on hepatic glucose production during heavy exercise. Am. J. Physiol. 1997 Nov; 273(5 Pt 1): E831-8. PMID: 9374667, ISSN: 0002-9513.

Coker RH, Krishna MG, Zinker BA, Allen EJ, Lacy DB, Wasserman DH. Sympathetic drive to liver and nonhepatic splanchnic tissue during prolonged exercise is increased in diabetes. Metab. Clin. Exp. 1997 Nov; 46(11): 1327-32. PMID: 9361694, PII: S0026-0495(97)90239-0, ISSN: 0026-0495.

Namdaran K, Bracy DP, Lacy DB, Johnson JL, Bupp JL, Wasserman DH. Gut and liver fat metabolism in depancreatized dogs: effects of exercise and acute insulin infusion. J. Appl. Physiol. 1997 Oct; 83(4): 1339-47. PMID: 9338445, ISSN: 8750-7587.

Zinker BA, Allison RG, Lacy DB, Wasserman DH. Interaction of exercise, insulin, and hypoglycemia studied using euglycemic and hypoglycemic insulin clamps. Am. J. Physiol. 1997 Apr; 272(4 Pt 1): E530-42. PMID: 9142871, ISSN: 0002-9513.

Coker RH, Krishna MG, Lacy DB, Allen EJ, Wasserman DH. Sympathetic drive to liver and nonhepatic splanchnic tissue during heavy exercise. J. Appl. Physiol. 1997 Apr; 82(4): 1244-9. PMID: 9104862, ISSN: 8750-7587.

O'Doherty RM, Bracy DP, Granner DK, Wasserman DH. Transcription of the rat skeletal muscle hexokinase II gene is increased by acute exercise. J. Appl. Physiol. 1996 Aug; 81(2): 789-93. PMID: 8872647, ISSN: 8750-7587.

Hamilton KS, Gibbons FK, Bracy DP, Lacy DB, Cherrington AD, Wasserman DH. Effect of prior exercise on the partitioning of an intestinal glucose load between splanchnic bed and skeletal muscle. J. Clin. Invest. 1996 Jul 7/1/1996; 98(1): 125-35. PMID: 8690783, PMCID: PMC507408, DOI: 10.1172/JCI118756, ISSN: 0021-9738.

Williams BD, Wolfe RR, Bracy DP, Wasserman DH. Gut proteolysis contributes essential amino acids during exercise. Am. J. Physiol. 1996 Jan; 270(1 Pt 1): E85-90. PMID: 8772478, ISSN: 0002-9513.

Wasserman DH, O'Doherty RM, Zinker BA. Role of the endocrine pancreas in control of fuel metabolism by the liver during exercise. Int. J. Obes. Relat. Metab. Disord. 1995 Oct; 19 Suppl 4: S22-30. PMID: 8581091.

Zinker BA, Wilson RD, Wasserman DH. Interaction of decreased arterial PO2 and exercise on carbohydrate metabolism in the dog. Am. J. Physiol. 1995 Sep; 269(3 Pt 1): E409-17. PMID: 7573417, ISSN: 0002-9513.

Bracy DP, Zinker BA, Jacobs JC, Lacy DB, Wasserman DH. Carbohydrate metabolism during exercise: influence of circulating fat availability. J. Appl. Physiol. 1995 Aug; 79(2): 506-13. PMID: 7592210, ISSN: 8750-7587.

Goldstein RE, Abumrad NN, Lacy DB, Wasserman DH, Cherrington AD. Effects of an acute increase in epinephrine and cortisol on carbohydrate metabolism during insulin deficiency. Diabetes. 1995 Jun; 44(6): 672-81. PMID: 7789632, ISSN: 0012-1797.

Zinker BA, Wilson R, Wasserman DH. Contribution of pancreatic hormone responses to the elevation in carbohydrate metabolism with reduced PaO2. Am. J. Physiol. 1995 Jun; 268(6 Pt 1): E1174-83. PMID: 7611394, ISSN: 0002-9513.

Wasserman DH. Regulation of glucose fluxes during exercise in the postabsorptive state. Annu. Rev. Physiol. 1995; 57: 191-218. PMID: 7778865, DOI: 10.1146/annurev.ph.57.030195.001203, ISSN: 0066-4278.

Wasserman DH, Ruzumna PA, Bracy DP, Lacy DB, Boothe HW, Williams PE, Abumrad NN. Impact of suprapharmacological androgenic steroid administration on basal and insulin-stimulated glucose and amino acid metabolism. Metab. Clin. Exp. 1994 Oct; 43(10): 1266-74. PMID: 7934979, PII: 0026-0495(94)90221-6, ISSN: 0026-0495.

Berger CM, Sharis PJ, Bracy DP, Lacy DB, Wasserman DH. Sensitivity of exercise-induced increase in hepatic glucose production to glucose supply and demand. Am. J. Physiol. 1994 Sep; 267(3 Pt 1): E411-21. PMID: 7943221, ISSN: 0002-9513.

Wasserman DH, Zinman B. Exercise in individuals with IDDM. Diabetes Care. 1994 Aug; 17(8): 924-37. PMID: 7956645, ISSN: 0149-5992.

Zinker BA, Namdaran K, Wilson R, Lacy DB, Wasserman DH. Acute adaptation of carbohydrate metabolism to decreased arterial PO2. Am. J. Physiol. 1994 Jun; 266(6 Pt 1): E921-9. PMID: 8023923, ISSN: 0002-9513.

Cherrington AD, Wasserman DH, McGinness OP. Renal contribution to glucose production after a brief fast: fact or fancy? [editorial]. J. Clin. Invest. 1994 Jun; 93(6): 2303. PMID: 8200961, PMCID: PMC294432, DOI: 10.1172/JCI117232, ISSN: 0021-9738.

Zinker BA, Mohr T, Kelly P, Namdaran K, Bracy DP, Wasserman DH. Exercise-induced fall in insulin: mechanism of action at the liver and effects on muscle glucose metabolism. Am. J. Physiol. 1994 May; 266(5 Pt 1): E683-9. PMID: 7911275, ISSN: 0002-9513.

Goldstein RE, Cherrington AD, Reed GW, Lacy DB, Wasserman DH, Abumrad NN. Effects of chronic hypercortisolemia on carbohydrate metabolism during insulin deficiency. Am. J. Physiol. 1994 Apr; 266(4 Pt 1): E618-27. PMID: 8178983, ISSN: 0002-9513.

O'Doherty RM, Bracy DP, Osawa H, Wasserman DH, Granner DK. Rat skeletal muscle hexokinase II mRNA and activity are increased by a single bout of acute exercise. Am. J. Physiol. 1994 Feb; 266(2 Pt 1): E171-8. PMID: 8141274, ISSN: 0002-9513.

Goldstein RE, Wasserman DH, Reed GW, Lacy DB, Abumrad NN, Cherrington AD. The effects of acute hypercortisolemia on beta-hydroxybutyrate and glycerol metabolism during insulin deficiency. Horm. Metab. Res. 1994 Jan; 26(1): 9-13. PMID: 7908656, DOI: 10.1055/s-2007-1000764, ISSN: 0018-5043.

Moore MC, Pagliassotti MJ, Wasserman DH, Goldstein R, Asher J, Neal DW, Cherrington AD. Hepatic denervation alters the transition from the fed to the food-deprived state in conscious dogs. J. Nutr. 1993 Oct; 123(10): 1739-46. PMID: 8410366, ISSN: 0022-3166.

Wasserman DH, Lacy DB, Bracy DP. Relationship between arterial and portal vein immunoreactive glucagon during exercise. J. Appl. Physiol. 1993 Aug; 75(2): 724-9. PMID: 8226475, ISSN: 8750-7587.

Zinker BA, Lacy DB, Bracy D, Jacobs J, Wasserman DH. Regulation of glucose uptake and metabolism by working muscle. An in vivo analysis. Diabetes. 1993 Jul; 42(7): 956-65. PMID: 8513977, ISSN: 0012-1797.

Wasserman DH, Johnson JL, Bupp JL, Lacy DB, Bracy DP. Regulation of gluconeogenesis during rest and exercise in the depancreatized dog. Am. J. Physiol. 1993 Jul; 265(1 Pt 1): E51-60. PMID: 8338154, ISSN: 0002-9513.

Zinker BA, Lacy DB, Bracy DP, Wasserman DH. Role of glucose and insulin loads to the exercising limb in increasing glucose uptake and metabolism. J. Appl. Physiol. 1993 Jun; 74(6): 2915-21. PMID: 8365992, ISSN: 8750-7587.

Connolly CC, Stevenson RW, Neal DW, Wasserman DH, Cherrington AD. The effects of lactate loading on alanine and glucose metabolism in the conscious dog. Metab. Clin. Exp. 1993 Feb; 42(2): 154-61. PMID: 8474311, ISSN: 0026-0495.

Goldstein RE, Wasserman DH, McGuinness OP, Lacy DB, Cherrington AD, Abumrad NN. Effects of chronic elevation in plasma cortisol on hepatic carbohydrate metabolism. Am. J. Physiol. 1993 Jan; 264(1 Pt 1): E119-27. PMID: 8430780, ISSN: 0002-9513.

Goldstein RE, Reed GW, Wasserman DH, Williams PE, Lacy DB, Buckspan R, Abumrad NN, Cherrington AD. The effects of acute elevations in plasma cortisol levels on alanine metabolism in the conscious dog. Metab. Clin. Exp. 1992 Dec; 41(12): 1295-303. PMID: 1461135, ISSN: 0026-0495.

Wasserman DH, Mohr T, Kelly P, Lacy DB, Bracy D. Impact of insulin deficiency on glucose fluxes and muscle glucose metabolism during exercise. Diabetes. 1992 Oct; 41(10): 1229-38. PMID: 1356861, ISSN: 0012-1797.

Hendrick GK, Wasserman DH, Frizzell RT, Williams PE, Lacy DB, Jaspan JB, Cherrington AD. Importance of basal glucagon in maintaining hepatic glucose production during a prolonged fast in conscious dogs. Am. J. Physiol. 1992 Sep; 263(3 Pt 1): E541-9. PMID: 1415534, ISSN: 0002-9513.

Wasserman DH, Lacy DB, Bracy D, Williams PE. Metabolic regulation in peripheral tissues and transition to increased gluconeogenic mode during prolonged exercise. Am. J. Physiol. 1992 Aug; 263(2 Pt 1): E345-54. PMID: 1514617, ISSN: 0002-9513.

Wasserman DH, Bupp JL, Johnson JL, Bracy D, Lacy DB. Glucoregulation during rest and exercise in depancreatized dogs: role of the acute presence of insulin. Am. J. Physiol. 1992 May; 262(5 Pt 1): E574-82. PMID: 1590369, ISSN: 0002-9513.

Wasserman DH, Lacy DB, Colburn CA, Bracy D, Cherrington AD. Efficiency of compensation for absence of fall in insulin during exercise. Am. J. Physiol. 1991 Nov; 261(5 Pt 1): E587-97. PMID: 1951683, ISSN: 0002-9513.

Wasserman DH, Connolly CC, Pagliassotti MJ. Regulation of hepatic lactate balance during exercise. Med Sci Sports Exerc. 1991 Aug; 23(8): 912-9. PMID: 1956264, ISSN: 0195-9131.

Wasserman DH, Cherrington AD. Hepatic fuel metabolism during muscular work: role and regulation [editorial]. Am. J. Physiol. 1991 Jun; 260(6 Pt 1): E811-24. PMID: 2058658, ISSN: 0002-9513.

Wasserman DH, Geer RJ, Williams PE, Becker T, Lacy DB, Abumrad NN. Interaction of gut and liver in nitrogen metabolism during exercise. Metab. Clin. Exp. 1991 Mar; 40(3): 307-14. PMID: 1672034, PII: 0026-0495(91)90115-D, ISSN: 0026-0495.

Wasserman DH, Geer RJ, Rice DE, Bracy D, Flakoll PJ, Brown LL, Hill JO, Abumrad NN. Interaction of exercise and insulin action in humans. Am. J. Physiol. 1991 Jan; 260(1 Pt 1): E37-45. PMID: 1987792, ISSN: 0002-9513.

Wasserman DH, Williams PE, Lacy DB, Bracy D, Cherrington AD. Hepatic nerves are not essential to the increase in hepatic glucose production during muscular work. Am. J. Physiol. 1990 Aug; 259(2 Pt 1): E195-203. PMID: 2200275, ISSN: 0002-9513.

Wasserman DH, Spalding JA, Lacy DB, Colburn CA, Goldstein RE, Cherrington AD. Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work. Am. J. Physiol. 1989 Jul; 257(1 Pt 1): E108-17. PMID: 2665514, ISSN: 0002-9513.

Wasserman DH, Abumrad NN. Physiological bases for the treatment of the physically active individual with diabetes. Sports Med. 1989 Jun; 7(6): 376-92. PMID: 2662324, ISSN: 0112-1642.

Wasserman DH, Spalding JA, Bracy D, Lacy DB, Cherrington AD. Exercise-induced rise in glucagon and ketogenesis during prolonged muscular work. Diabetes. 1989 Jun; 38(6): 799-807. PMID: 2566546, ISSN: 0012-1797.

Wasserman DH, Williams PE, Lacy DB, Goldstein RE, Cherrington AD. Exercise-induced fall in insulin and hepatic carbohydrate metabolism during muscular work. Am. J. Physiol. 1989 Apr; 256(4 Pt 1): E500-9. PMID: 2650562, ISSN: 0002-9513.

Wasserman DH, Lacy DB, Goldstein RE, Williams PE, Cherrington AD. Exercise-induced fall in insulin and increase in fat metabolism during prolonged muscular work. Diabetes. 1989 Apr; 38(4): 484-90. PMID: 2647555, ISSN: 0012-1797.

Moates JM, Lacy DB, Goldstein RE, Cherrington AD, Wasserman DH. Metabolic role of the exercise-induced increment in epinephrine in the dog. Am. J. Physiol. 1988 Oct; 255(4 Pt 1): E428-36. PMID: 3052103, ISSN: 0002-9513.

Wasserman DH, Williams PE, Lacy DB, Green DR, Cherrington AD. Importance of intrahepatic mechanisms to gluconeogenesis from alanine during exercise and recovery. Am. J. Physiol. 1988 Apr; 254(4 Pt 1): E518-25. PMID: 3281473, ISSN: 0002-9513.

Wasserman DH, Lacy DB, Green DR, Williams PE, Cherrington AD. Dynamics of hepatic lactate and glucose balances during prolonged exercise and recovery in the dog. J. Appl. Physiol. 1987 Dec; 63(6): 2411-7. PMID: 3325489, ISSN: 8750-7587.

Norwich KH, Wasserman DH. Calculation of metabolic fluxes with anatomically separated sources of tracer and tracee. Am. J. Physiol. 1986 Dec; 251(6 Pt 1): E715-20. PMID: 3538902, ISSN: 0002-9513.

Cooper DM, Wasserman DH, Vranic M, Wasserman K. Glucose turnover in response to exercise during high- and low-FIO2 breathing in man. Am. J. Physiol. 1986 Aug; 251(2 Pt 1): E209-14. PMID: 3526922, ISSN: 0002-9513.

Wasserman DH, Vranic M. Interaction between insulin and counterregulatory hormones in control of substrate utilization in health and diabetes during exercise. Diabetes Metab Rev. 1986; 1(4): 359-84. PMID: 2873005, ISSN: 0742-4221.

Wasserman DH, Lickley HL, Vranic M. Role of beta-adrenergic mechanisms during exercise in poorly controlled diabetes. J. Appl. Physiol. 1985 Oct; 59(4): 1282-9. PMID: 2865246, ISSN: 8750-7587.

Wasserman DH, Lickley HL, Vranic M. Important role of glucagon during exercise in diabetic dogs. J. Appl. Physiol. 1985 Oct; 59(4): 1272-81. PMID: 2865245, ISSN: 8750-7587.

Wasserman DH, Lavina H, Lickley A, Vranic M. Effect of hematocrit reduction on hormonal and metabolic responses to exercise. J. Appl. Physiol. 1985 Apr; 58(4): 1257-62. PMID: 3886622, ISSN: 8750-7587.

Wasserman DH, Lickley HL, Vranic M. Interactions between glucagon and other counterregulatory hormones during normoglycemic and hypoglycemic exercise in dogs. J. Clin. Invest. 1984 Oct; 74(4): 1404-13. PMID: 6148356, PMCID: PMC425308, DOI: 10.1172/JCI111551, ISSN: 0021-9738.

Wasserman DH, Whipp BJ. Coupling of ventilation to pulmonary gas exchange during nonsteady-state work in men. J Appl Physiol Respir Environ Exerc Physiol. 1983 Feb; 54(2): 587-93. PMID: 6833054, ISSN: 0161-7567.