Fiona E. Yull, D.Phil.

Associate Professor

fiona.yull@vanderbilt.edu
Faculty Appointments
Associate Professor of Cancer Biology
Education
D.Phil., Biochemistry , University of Oxford, Oxford, United KingdomB.Sc., St Andrews University, United Kingdom
Office Address
B3302 Medical Center North
TN 6840
Research Description
The NF-kappaB family of transcription factors are regulators of many critical processes such as proliferation, apoptosis, immune responses and inflammation. It is, therefore, unsurprising that they play roles in basic development but also in most diseases including cancer. Our laboratory has generated a number of mouse models to investigate these roles in development; breast, lungs, limbs and immune system. We are also interested in the roles played by NF-kappaB signaling in disease. We are currently primarily interested in breast and lung cancer. We have generated a number of interesting models that we use for our research. Our transgenic reporter mice express a GFP/luciferase fusion protein that can emit light in response to NF-kappaB activity. With these we can monitor activation in a living animal using a CCD camera and use immunohistochemical techniques to identify specific cell types in which NF-kappaB is active. We have also generated a modular inducible system that enables us to turn up or down NF-kappaB activity in specific cell types eg. mammary or lung epithelium or macrophages. We are using multiple models to study the effects of modulating NF-kappaB activity on normal breast development, early stages of primary breast tumor development and on metastasis to the lungs.
Research Keywords
Generation of mouse models to investigate NF-kappaB in development and disease
Publications
Stouch AN, Zaynagetdinov R, Barham WJ, Stinnett AM, Slaughter JC, Yull FE, Hoffman HM, Blackwell TS, Prince LS. I¿B kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm. J. Immunol [print-electronic]. 2014 Aug 8/1/2014; 193(3): 1184-93. PMID: 24981452, PMCID: PMC4108541, PII: jimmunol.1302516, DOI: 10.4049/jimmunol.1302516, ISSN: 1550-6606.

Jin R, Yi Y, Yull FE, Blackwell TS, Clark PE, Koyama T, Smith JA, Matusik RJ. NF-¿B gene signature predicts prostate cancer progression. Cancer Res [print-electronic]. 2014 May 5/15/2014; 74(10): 2763-72. PMID: 24686169, PMCID: PMC4024337, PII: 0008-5472.CAN-13-2543, DOI: 10.1158/0008-5472.CAN-13-2543, ISSN: 1538-7445.

Shi C, Washington MK, Chaturvedi R, Drosos Y, Revetta FL, Weaver CJ, Buzhardt E, Yull FE, Blackwell TS, Sosa-Pineda B, Whitehead RH, Beauchamp RD, Wilson KT, Means AL. Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Lab. Invest [print-electronic]. 2014 Apr; 94(4): 409-21. PMID: 24535260, PMCID: PMC3992484, PII: labinvest201410, DOI: 10.1038/labinvest.2014.10, ISSN: 1530-0307.

Han W, Li H, Cai J, Gleaves LA, Polosukhin VV, Segal BH, Yull FE, Blackwell TS. NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-¿B activity. J. Immunol [print-electronic]. 2013 May 5/1/2013; 190(9): 4786-94. PMID: 23530143, PMCID: PMC3633681, PII: jimmunol.1201809, DOI: 10.4049/jimmunol.1201809, ISSN: 1550-6606.

Edwards JR, Perrien DS, Fleming N, Nyman JS, Ono K, Connelly L, Moore MM, Lwin ST, Yull FE, Mundy GR, Elefteriou F. Silent information regulator (Sir)T1 inhibits NF-¿B signaling to maintain normal skeletal remodeling. J. Bone Miner. Res. 2013 Apr; 28(4): 960-9. PMID: 23172686, DOI: 10.1002/jbmr.1824, ISSN: 1523-4681.

Yu SS, Lau CM, Barham WJ, Onishko HM, Nelson CE, Li H, Smith CA, Yull FE, Duvall CL, Giorgio TD. Macrophage-specific RNA interference targeting via "click", mannosylated polymeric micelles. Mol. Pharm [print-electronic]. 2013 Mar 3/4/2013; 10(3): 975-87. PMID: 23331322, PMCID: PMC3595119, DOI: 10.1021/mp300434e, ISSN: 1543-8392.

Li H, Han W, Polosukhin V, Yull FE, Segal BH, Xie CM, Blackwell TS. NF-¿B inhibition after cecal ligation and puncture reduces sepsis-associated lung injury without altering bacterial host defense. Mediators Inflamm [print-electronic]. 2013; 2013: 503213. PMID: 24347827, PMCID: PMC3852536, DOI: 10.1155/2013/503213, ISSN: 1466-1861.

Zaynagetdinov R, Stathopoulos GT, Sherrill TP, Cheng DS, McLoed AG, Ausborn JA, Polosukhin VV, Connelly L, Zhou W, Fingleton B, Peebles RS, Prince LS, Yull FE, Blackwell TS. Epithelial nuclear factor-¿B signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene [print-electronic]. 2012 Jun 6/28/2012; 31(26): 3164-76. PMID: 22002309, PMCID: PMC3266969, PII: onc2011480, DOI: 10.1038/onc.2011.480, ISSN: 1476-5594.

Barham W, Sherrill T, Connelly L, Blackwell TS, Yull FE. Intraductal injection of LPS as a mouse model of mastitis: signaling visualized via an NF-¿B reporter transgenic. J Vis Exp. 2012; (67): e4030. PMID: 22971993, PMCID: PMC3490260, PII: 4030, DOI: 10.3791/4030, ISSN: 1940-087X.

Zaynagetdinov R, Sherrill TP, Polosukhin VV, Han W, Ausborn JA, McLoed AG, McMahon FB, Gleaves LA, Degryse AL, Stathopoulos GT, Yull FE, Blackwell TS. A critical role for macrophages in promotion of urethane-induced lung carcinogenesis. J. Immunol [print-electronic]. 2011 Dec 12/1/2011; 187(11): 5703-11. PMID: 22048774, PMCID: PMC3221921, PII: jimmunol.1100558, DOI: 10.4049/jimmunol.1100558, ISSN: 1550-6606.

Blackwell TS, Hipps AN, Yamamoto Y, Han W, Barham WJ, Ostrowski MC, Yull FE, Prince LS. NF-¿B signaling in fetal lung macrophages disrupts airway morphogenesis. J. Immunol [print-electronic]. 2011 Sep 9/1/2011; 187(5): 2740-7. PMID: 21775686, PMCID: PMC3159744, PII: jimmunol.1101495, DOI: 10.4049/jimmunol.1101495, ISSN: 1550-6606.

Lawson WE, Cheng DS, Degryse AL, Tanjore H, Polosukhin VV, Xu XC, Newcomb DC, Jones BR, Roldan J, Lane KB, Morrisey EE, Beers MF, Yull FE, Blackwell TS. Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2011 Jun 6/28/2011; 108(26): 10562-7. PMID: 21670280, PMCID: PMC3127925, PII: 1107559108, DOI: 10.1073/pnas.1107559108, ISSN: 1091-6490.

Connelly L, Barham W, Onishko HM, Sherrill T, Chodosh LA, Blackwell TS, Yull FE. Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden. Oncogene [print-electronic]. 2011 Mar 3/24/2011; 30(12): 1402-12. PMID: 21076466, PMCID: PMC3063854, PII: onc2010521, DOI: 10.1038/onc.2010.521, ISSN: 1476-5594.

Connelly L, Barham W, Onishko HM, Chen L, Sherrill TP, Zabuawala T, Ostrowski MC, Blackwell TS, Yull FE. NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model. Breast Cancer Res. 2011; 13(4): R83. PMID: 21884585, PMCID: PMC3236346, PII: bcr2935, DOI: 10.1186/bcr2935, ISSN: 1465-542X.

Stathopoulos GT, Sherrill TP, Karabela SP, Goleniewska K, Kalomenidis I, Roussos C, Fingleton B, Yull FE, Peebles RS, Blackwell TS. Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion. Am. J. Respir. Crit. Care Med [print-electronic]. 2010 Nov 11/15/2010; 182(10): 1273-81. PMID: 20595227, PMCID: PMC3001265, PII: 201001-0001OC, DOI: 10.1164/rccm.201001-0001OC, ISSN: 1535-4970.

Yang J, Splittgerber R, Yull FE, Kantrow S, Ayers GD, Karin M, Richmond A. Conditional ablation of Ikkb inhibits melanoma tumor development in mice. J. Clin. Invest [print-electronic]. 2010 Jul; 120(7): 2563-74. PMID: 20530876, PMCID: PMC2898608, PII: 42358, DOI: 10.1172/JCI42358, ISSN: 1558-8238.

Connelly L, Barham W, Pigg R, Saint-Jean L, Sherrill T, Cheng DS, Chodosh LA, Blackwell TS, Yull FE. Activation of nuclear factor kappa B in mammary epithelium promotes milk loss during mammary development and infection. J. Cell. Physiol. 2010 Jan; 222(1): 73-81. PMID: 19746431, PMCID: PMC2783968, DOI: 10.1002/jcp.21922, ISSN: 1097-4652.

Segal BH, Han W, Bushey JJ, Joo M, Bhatti Z, Feminella J, Dennis CG, Vethanayagam RR, Yull FE, Capitano M, Wallace PK, Minderman H, Christman JW, Sporn MB, Chan J, Vinh DC, Holland SM, Romani LR, Gaffen SL, Freeman ML, Blackwell TS. NADPH oxidase limits innate immune responses in the lungs in mice. PLoS ONE. 2010; 5(3): e9631. PMID: 20300512, PMCID: PMC2838778, DOI: 10.1371/journal.pone.0009631, ISSN: 1932-6203.

Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR. The protein kinase IKKepsilon regulates energy balance in obese mice. Cell. 2009 Sep 9/4/2009; 138(5): 961-75. PMID: 19737522, PMCID: PMC2756060, PII: S0092-8674(09)00793-4, DOI: 10.1016/j.cell.2009.06.046, ISSN: 1097-4172.

Singh MV, Kapoun A, Higgins L, Kutschke W, Thurman JM, Zhang R, Singh M, Yang J, Guan X, Lowe JS, Weiss RM, Zimmermann K, Yull FE, Blackwell TS, Mohler PJ, Anderson ME. Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. J. Clin. Invest [print-electronic]. 2009 Apr; 119(4): 986-96. PMID: 19273909, PMCID: PMC2662543, PII: 35814, DOI: 10.1172/JCI35814, ISSN: 1558-8238.

Han W, Joo M, Everhart MB, Christman JW, Yull FE, Blackwell TS. Myeloid cells control termination of lung inflammation through the NF-kappaB pathway. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2009 Mar; 296(3): L320-7. PMID: 19098124, PMCID: PMC2660215, PII: 90485.2008, DOI: 10.1152/ajplung.90485.2008, ISSN: 1040-0605.

Chen SM, Cheng DS, Williams BJ, Sherrill TP, Han W, Chont M, Saint-Jean L, Christman JW, Sadikot RT, Yull FE, Blackwell TS. The nuclear factor kappa-B pathway in airway epithelium regulates neutrophil recruitment and host defence following Pseudomonas aeruginosa infection. Clin. Exp. Immunol [print-electronic]. 2008 Sep; 153(3): 420-8. PMID: 18647324, PMCID: PMC2527362, PII: CEI3707, DOI: 10.1111/j.1365-2249.2008.03707.x, ISSN: 1365-2249.

Jin RJ, Lho Y, Connelly L, Wang Y, Yu X, Saint Jean L, Case TC, Ellwood-Yen K, Sawyers CL, Bhowmick NA, Blackwell TS, Yull FE, Matusik RJ. The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth. Cancer Res. 2008 Aug 8/15/2008; 68(16): 6762-9. PMID: 18701501, PMCID: PMC2840631, PII: 68/16/6762, DOI: 10.1158/0008-5472.CAN-08-0107, ISSN: 1538-7445.

Stathopoulos GT, Sherrill TP, Han W, Sadikot RT, Yull FE, Blackwell TS, Fingleton B. Host nuclear factor-kappaB activation potentiates lung cancer metastasis. Mol. Cancer Res. 2008 Mar; 6(3): 364-71. PMID: 18337446, PII: 6/3/364, DOI: 10.1158/1541-7786.MCR-07-0309, ISSN: 1541-7786.

Stathopoulos GT, Sherrill TP, Han W, Sadikot RT, Polosukhin VV, Fingleton B, Yull FE, Blackwell TS. Use of bioluminescent imaging to investigate the role of nuclear factor-kappaBeta in experimental non-small cell lung cancer metastasis. Clin. Exp. Metastasis [print-electronic]. 2008; 25(1): 43-51. PMID: 18008176, DOI: 10.1007/s10585-007-9100-z, ISSN: 0262-0898.

Stathopoulos GT, Sherrill TP, Cheng DS, Scoggins RM, Han W, Polosukhin VV, Connelly L, Yull FE, Fingleton B, Blackwell TS. Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2007 Nov 11/20/2007; 104(47): 18514-9. PMID: 18000061, PMCID: PMC2141808, PII: 0705316104, DOI: 10.1073/pnas.0705316104, ISSN: 1091-6490.

Park GY, Hu N, Wang X, Sadikot RT, Yull FE, Joo M, Peebles RS, Blackwell TS, Christman JW. Conditional regulation of cyclooxygenase-2 in tracheobronchial epithelial cells modulates pulmonary immunity. Clin. Exp. Immunol [print-electronic]. 2007 Nov; 150(2): 245-54. PMID: 17672868, PMCID: PMC2219354, PII: CEI3478, DOI: 10.1111/j.1365-2249.2007.03478.x, ISSN: 1365-2249.

Cheng DS, Han W, Chen SM, Sherrill TP, Chont M, Park GY, Sheller JR, Polosukhin VV, Christman JW, Yull FE, Blackwell TS. Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway. J. Immunol. 2007 May 5/15/2007; 178(10): 6504-13. PMID: 17475880, PII: 178/10/6504, ISSN: 0022-1767.

Connelly L, Robinson-Benion C, Chont M, Saint-Jean L, Li H, Polosukhin VV, Blackwell TS, Yull FE. A transgenic model reveals important roles for the NF-kappa B alternative pathway (p100/p52) in mammary development and links to tumorigenesis. J. Biol. Chem [print-electronic]. 2007 Mar 3/30/2007; 282(13): 10028-35. PMID: 17261585, PII: M611300200, DOI: 10.1074/jbc.M611300200, ISSN: 0021-9258.

Everhart MB, Han W, Sherrill TP, Arutiunov M, Polosukhin VV, Burke JR, Sadikot RT, Christman JW, Yull FE, Blackwell TS. Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. J. Immunol. 2006 Apr 4/15/2006; 176(8): 4995-5005. PMID: 16585596, PII: 176/8/4995, ISSN: 0022-1767.

Sadikot RT, Zeng H, Joo M, Everhart MB, Sherrill TP, Li B, Cheng DS, Yull FE, Christman JW, Blackwell TS. Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa. J. Immunol. 2006 Apr 4/15/2006; 176(8): 4923-30. PMID: 16585588, PII: 176/8/4923, ISSN: 0022-1767.

Stafforini DM, Sheller JR, Blackwell TS, Sapirstein A, Yull FE, McIntyre TM, Bonventre JV, Prescott SM, Roberts LJ. Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases. J. Biol. Chem [print-electronic]. 2006 Feb 2/24/2006; 281(8): 4616-23. PMID: 16371369, PII: M507340200, DOI: 10.1074/jbc.M507340200, ISSN: 0021-9258.

Stathopoulos GT, Zhu Z, Everhart MB, Kalomenidis I, Lawson WE, Bilaceroglu S, Peterson TE, Mitchell D, Yull FE, Light RW, Blackwell TS. Nuclear factor-kappaB affects tumor progression in a mouse model of malignant pleural effusion. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2006 Feb; 34(2): 142-50. PMID: 16210694, PMCID: PMC2644178, PII: 2005-0130OC, DOI: 10.1165/rcmb.2005-0130OC, ISSN: 1044-1549.

O'Donnell SM, Hansberger MW, Connolly JL, Chappell JD, Watson MJ, Pierce JM, Wetzel JD, Han W, Barton ES, Forrest JC, Valyi-Nagy T, Yull FE, Blackwell TS, Rottman JN, Sherry B, Dermody TS. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J. Clin. Invest [print-electronic]. 2005 Sep; 115(9): 2341-50. PMID: 16100570, PMCID: PMC1184036, DOI: 10.1172/JCI22428, ISSN: 0021-9738.

Everhart MB, Han W, Parman KS, Polosukhin VV, Zeng H, Sadikot RT, Li B, Yull FE, Christman JW, Blackwell TS. Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation. J. Leukoc. Biol [print-electronic]. 2005 Feb; 77(2): 173-80. PMID: 15563581, PII: jlb.1203647, DOI: 10.1189/jlb.1203647, ISSN: 0741-5400.

Ponnappan U, Yull FE, Soderberg LS. Inhaled isobutyl nitrite inhibited macrophage inducible nitric oxide by blocking NFkappaB signaling and promoting degradation of inducible nitric oxide synthase-2. Int. Immunopharmacol. 2004 Aug; 4(8): 1075-82. PMID: 15222982, PII: S1567-5769(04)00144-4, DOI: 10.1016/j.intimp.2004.04.014, ISSN: 1567-5769.

Schneider C, Strayhorn WD, Brantley DM, Nanney LB, Yull FE, Brash AR. Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice. J. Invest. Dermatol. 2004 Mar; 122(3): 691-8. PMID: 15086555, PII: JID22329, DOI: 10.1111/j.0022-202X.2004.22329.x, ISSN: 0022-202X.

Sadikot RT, Zeng H, Yull FE, Li B, Cheng DS, Kernodle DS, Jansen ED, Contag CH, Segal BH, Holland SM, Blackwell TS, Christman JW. P47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia. J. Immunol. 2004 Feb 2/1/2004; 172(3): 1801-8. PMID: 14734763, ISSN: 0022-1767.

Yull FE, Han W, Jansen ED, Everhart MB, Sadikot RT, Christman JW, Blackwell TS. Bioluminescent detection of endotoxin effects on HIV-1 LTR-driven transcription in vivo. J. Histochem. Cytochem. 2003 Jun; 51(6): 741-9. PMID: 12754285, ISSN: 0022-1554.

Gray KD, Simovic MO, Chapman WC, Blackwell TS, Christman JW, Washington MK, Yull FE, Jaffal N, Jansen ED, Gautman S, Stain SC. Systemic nf-kappaB activation in a transgenic mouse model of acute pancreatitis. J. Surg. Res. 2003 Mar; 110(1): 310-4. PMID: 12697416, PII: S0022480403000246, ISSN: 0022-4804.

Sadikot RT, Han W, Everhart MB, Zoia O, Peebles RS, Jansen ED, Yull FE, Christman JW, Blackwell TS. Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation. J. Immunol. 2003 Jan 1/15/2003; 170(2): 1091-8. PMID: 12517978, ISSN: 0022-1767.

Sadikot RT, Wudel LJ, Jansen DE, Debelak JP, Yull FE, Christman JW, Blackwell TS, Chapman WC. Hepatic cryoablation-induced multisystem injury: bioluminescent detection of NF-kappaB activation in a transgenic mouse model. J. Gastrointest. Surg. 2002 Mar; 6(2): 264-70. PMID: 11992813, PII: S1091255X01000646, ISSN: 1091-255X.

Sadikot RT, Jansen ED, Blackwell TR, Zoia O, Yull F, Christman JW, Blackwell TS. High-dose dexamethasone accentuates nuclear factor-kappa b activation in endotoxin-treated mice. Am. J. Respir. Crit. Care Med. 2001 Sep 9/1/2001; 164(5): 873-8. PMID: 11549548, DOI: 10.1164/ajrccm.164.5.2008059, ISSN: 1073-449X.

Bushdid PB, Chen CL, Brantley DM, Yull F, Raghow R, Kerr LD, Barnett JV. NF-kappaB mediates FGF signal regulation of msx-1 expression. Dev. Biol. 2001 Sep 9/1/2001; 237(1): 107-15. PMID: 11518509, PII: S0012-1606(01)90356-2, DOI: 10.1006/dbio.2001.0356, ISSN: 0012-1606.

Brantley DM, Chen CL, Muraoka RS, Bushdid PB, Bradberry JL, Kittrell F, Medina D, Matrisian LM, Kerr LD, Yull FE. Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium. Mol. Biol. Cell. 2001 May; 12(5): 1445-55. PMID: 11359934, PMCID: PMC34596, ISSN: 1059-1524.

Chen CL, Yull FE, Cardwell N, Singh N, Strayhorn WD, Nanney LB, Kerr LD. RAG2-/-, I kappa B-alpha-/- chimeras display a psoriasiform skin disease. J. Invest. Dermatol. 2000 Dec; 115(6): 1124-33. PMID: 11121151, PII: jid162, DOI: 10.1046/j.1523-1747.2000.00162.x, ISSN: 0022-202X.

Chen CL, Singh N, Yull FE, Strayhorn D, Van Kaer L, Kerr LD. Lymphocytes lacking I kappa B-alpha develop normally, but have selective defects in proliferation and function. J. Immunol. 2000 Nov 11/15/2000; 165(10): 5418-27. PMID: 11067893, ISSN: 0022-1767.

Hao CM, Yull F, Blackwell T, Kömhoff M, Davis LS, Breyer MD. Dehydration activates an NF-kappaB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells. J. Clin. Invest. 2000 Oct; 106(8): 973-82. PMID: 11032857, PMCID: PMC314340, DOI: 10.1172/JCI9956, ISSN: 0021-9738.

Brantley DM, Yull FE, Muraoka RS, Hicks DJ, Cook CM, Kerr LD. Dynamic expression and activity of NF-kappaB during post-natal mammary gland morphogenesis. Mech. Dev. 2000 Oct; 97(1-2): 149-55. PMID: 11025216, PII: S0925477300004056, ISSN: 0925-4773.

Muraoka RS, Bushdid PB, Brantley DM, Yull FE, Kerr LD. Mesenchymal expression of nuclear factor-kappaB inhibits epithelial growth and branching in the embryonic chick lung. Dev. Biol. 2000 Sep 9/15/2000; 225(2): 322-38. PMID: 10985853, PII: S0012-1606(00)99824-5, DOI: 10.1006/dbio.2000.9824, ISSN: 0012-1606.

Blackwell TS, Yull FE, Chen CL, Venkatakrishnan A, Blackwell TR, Hicks DJ, Lancaster LH, Christman JW, Kerr LD. Multiorgan nuclear factor kappa B activation in a transgenic mouse model of systemic inflammation. Am. J. Respir. Crit. Care Med. 2000 Sep; 162(3 Pt 1): 1095-101. PMID: 10988136, DOI: 10.1164/ajrccm.162.3.9906129, ISSN: 1073-449X.

Sohur US, Chen CL, Hicks DJ, Yull FE, Kerr LD. Nuclear factor-kappaB/Rel is apoptogenic in cytokine withdrawal-induced programmed cell death. Cancer Res. 2000 Mar 3/1/2000; 60(5): 1202-5. PMID: 10728675, ISSN: 0008-5472.

Blackwell TS, Yull FE, Chen CL, Venkatakrishnan A, Blackwell TR, Hicks DJ, Lancaster LH, Christman JW, Kerr LD. Use of genetically altered mice to investigate the role of nuclear factor-kappa B activation and cytokine gene expression in sepsis-induced ARDS. Chest. 1999 Jul; 116(1 Suppl): 73S-74S. PMID: 10424600, ISSN: 0012-3692.

Chen CL, Yull FE, Kerr LD. Differential serine phosphorylation regulates IkappaB-alpha inactivation. Biochem. Biophys. Res. Commun. 1999 Apr 4/21/1999; 257(3): 798-806. PMID: 10208863, PII: S0006-291X(99)90548-X, DOI: 10.1006/bbrc.1999.0548, ISSN: 0006-291X.

Bushdid PB, Brantley DM, Yull FE, Blaeuer GL, Hoffman LH, Niswander L, Kerr LD. Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Nature. 1998 Apr 4/9/1998; 392(6676): 615-8. PMID: 9560159, DOI: 10.1038/33435, ISSN: 0028-0836.

Clark AJ, Harold G, Yull FE. Mammalian cDNA and prokaryotic reporter sequences silence adjacent transgenes in transgenic mice. Nucleic Acids Res. 1997 Mar 3/1/1997; 25(5): 1009-14. PMID: 9023112, PMCID: PMC146529, PII: gka175, ISSN: 0305-1048.

Clark AJ, Iwobi M, Cui W, Crompton M, Harold G, Hobbs S, Kamalati T, Knox R, Neil C, Yull F, Gusterson B. Selective cell ablation in transgenic mice expression E. coli nitroreductase. Gene Ther. 1997 Feb; 4(2): 101-10. PMID: 9081700, ISSN: 0969-7128.

Yull F, Binas B, Harold G, Wallace R, Clark AJ. Transgene rescue in the mammary gland is associated with transcription but does not require translation of BLG transgenes. Transgenic Res. 1997 Jan; 6(1): 11-7. PMID: 9032973, ISSN: 0962-8819.

Yull F, Harold G, Wallace R, Cowper A, Percy J, Cottingham I, Clark AJ. Fixing human factor IX (fIX): correction of a cryptic RNA splice enables the production of biologically active fIX in the mammary gland of transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 1995 Nov 11/21/1995; 92(24): 10899-903. PMID: 7479906, PMCID: PMC40538, ISSN: 0027-8424.

Yull FE, Wallace RM, Clark AJ. Restricted tissue-specific but correct developmental expression mediated by a short human alpha 1AT promoter fragment in transgenic mice. Transgenic Res. 1995 Jan; 4(1): 70-4. PMID: 7881464, ISSN: 0962-8819.

Clark AJ, Bissinger P, Bullock DW, Damak S, Wallace R, Whitelaw CB, Yull F. Chromosomal position effects and the modulation of transgene expression. Reprod. Fertil. Dev. 1994; 6(5): 589-98. PMID: 7569038, ISSN: 1031-3613.

Dobson MJ, Yull FE, Molina M, Kingsman SM, Kingsman AJ. Reconstruction of the yeast 2 micron plasmid partitioning mechanism. Nucleic Acids Res. 1988 Jul 7/25/1988; 16(14B): 7103-17. PMID: 3043377, PMCID: PMC338354, ISSN: 0305-1048.