J. Jeffrey Reese, M.D.

Professor

jeff.reese@vanderbilt.edu

Visit Lab Site


Faculty Appointments
Professor of Pediatrics Associate Professor of Biomedical EngineeringAssociate Professor of Cell and Developmental BiologyMildred Thornton Stahlman Chair in Perinatology
Education
M.D., University of Kansas, Kansas City, KansasB.A., Mathematics, University of Kansas, Lawrence, Kansas
Office Address
1125 MRB IV
Nashville, TN 37232-0656
Research Description
Our lab is interested in the mechanisms of embryo-uterine interactions at the time of implantation and fetal-maternal interactions at the time of birth. During early pregnancy, a tightly regulated series of molecular signals coordinates uterine receptivity and activation of the developing embryo. In collaboration with other Vanderbilt investigators, we are examining the role of growth factors, cytokines and prostaglandins in the establishment of pregnancy. Genomic screens have also identified numerous factors that are upregulated at the time of implantation, but whose function in this process is unknown. Current research projects are aimed at resolving the contribution of these gene families to embryo implantation.

We are also examining the role of prostaglandins in term and preterm birth. Prostaglandins are products of arachidonic acid metabolism with vasoactive and mitogenic properties, and are likely downstream mediators of growth factor signaling. Cyclooxygenase (COX) is the rate-limiting enzyme in prostaglandin synthesis. COX-1 is the constitutive isoform of this enzyme whose expression is developmentally regulated, while COX-2 is expressed in response to inflammatory stimuli. We observed reduced vascular permeability and prostaglandin concentrations in the uteri of COX-1 deficient mice. However, COX-1 deficient uteri have compensatory upregulation of COX-2, suggesting a mechanism to preserve fertility. COX-1 null mice are also remarkable for their inability to complete labor or deliver healthy pups. We found that COX-1 deficient mice can deliver in a timely fashion when carrying a litter of wildtype pups (by embryo transfer). There are few mouse models that display parturition failure and offer the opportunity to examine the molecular basis of labor.

As part of these studies, COX-1/COX-2 double knockout mice have also been bred. These mice have perinatal lethality, possibly due to abnormal regulation of the ductus arteriosus, a fetal vascular shunt that is necessary for survival in-utero. Our newest area of research is to further evaluate the mechanisms of ductus arteriosus regulation using the mouse as a model. We are currently using mice with targeted deletions in both COX1 and COX2 and mice lacking a prostaglandin E receptor, which also die with a patent ductus arteriosus soon after birth. Studies in these mice may reveal novel mechanisms for the rapid sequence of vascular changes that take place during the transition from fetal to neonatal life. Together, these models are invaluable resources for the evaluation of prostaglandin actions in maternal-fetal communication during reproduction and during fetal organogenesis.

Links:
http://www.mc.vanderbilt.edu/lens/article/?id=231&pg=999

http://ontheirway.vanderbiltchildrens.org/?article=8952

http://news.vanderbilt.edu/2013/06/antacids-risky-for-premature-babies/
Publications
Hooper CW, Delaney C, Streeter T, Yarboro MT, Poole SD, Brown N, Slaughter JC, Cotton RB, Reese J, Shelton EL. Selective serotonin reuptake inhibitor (SSRI) exposure constricts the mouse ductus arteriosus in utero. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2016 Jul 7/1/2016; ajpheart.00822.2015. PMID: 27371685, PII: ajpheart.00822.2015, DOI: 10.1152/ajpheart.00822.2015, ISSN: 1522-1539.

Kraemer MP, Choi H, Reese J, Lamb FS, Breyer RM. Regulation of arterial reactivity by concurrent signaling through the E-prostanoid receptor 3 and angiotensin receptor 1. Vascul. Pharmacol [print-electronic]. 2016 May 5/31/2016; PMID: 27260940, PII: S1537-1891(16)30016-7, DOI: 10.1016/j.vph.2016.05.015, ISSN: 1879-3649.

Reese J, Laughon MM. The Patent Ductus Arteriosus Problem: Infants Who Still Need Treatment [editorial]. J. Pediatr [print-electronic]. 2015 Nov; 167(5): 954-6. PMID: 26316368, PII: S0022-3476(15)00879-3, DOI: 10.1016/j.jpeds.2015.08.023, ISSN: 1097-6833.

Waleh N, Barrette AM, Dagle JM, Momany A, Jin C, Hills NK, Shelton EL, Reese J, Clyman RI. Effects of Advancing Gestation and Non-Caucasian Race on Ductus Arteriosus Gene Expression. J. Pediatr [print-electronic]. 2015 Nov; 167(5): 1033-1041.e2. PMID: 26265282, PMCID: PMC4661123, PII: S0022-3476(15)00733-7, DOI: 10.1016/j.jpeds.2015.07.011, ISSN: 1097-6833.

Coggins SA, Weitkamp JH, Grunwald L, Stark AR, Reese J, Walsh W, Wynn JL. Heart rate characteristic index monitoring for bloodstream infection in an NICU: a 3-year experience. Arch. Dis. Child. Fetal Neonatal Ed [print-electronic]. 2015 Oct 10/30/2015; PMID: 26518312, PII: archdischild-2015-309210, DOI: 10.1136/archdischild-2015-309210, ISSN: 1468-2052.

Mitchener MM, Hermanson DJ, Shockley EM, Brown HA, Lindsley CW, Reese J, Rouzer CA, Lopez CF, Marnett LJ. Competition and allostery govern substrate selectivity of cyclooxygenase-2. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2015 Oct 10/6/2015; 112(40): 12366-71. PMID: 26392530, PMCID: PMC4603459, PII: 1507307112, DOI: 10.1073/pnas.1507307112, ISSN: 1091-6490.

Reese J, Bry K, Hascoet JM. Robert B. Cotton recalled as devoted teacher, mentor, and scientist. Acta Paediatr. 2015 May; 104(5): 536-7. PMID: 25873410, DOI: 10.1111/apa.12995, ISSN: 1651-2227.

Noori S, McNamara P, Jain A, Lavoie PM, Wickremasinghe A, Merritt TA, Solomon T, Sekar K, Attridge JT, Swanson JR, Gillam-Krakauer M, Reese J, Poindexter BB, Brook M, Auchus RJ, Clyman RI, . Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation. J Perinatol [print-electronic]. 2015 Feb; 35(2): 123-7. PMID: 25118721, PMCID: PMC4310792, PII: jp2014151, DOI: 10.1038/jp.2014.151, ISSN: 1476-5543.

Herington JL, Swale DR, Brown N, Shelton EL, Choi H, Williams CH, Hong CC, Paria BC, Denton JS, Reese J. High-Throughput Screening of Myometrial Calcium-Mobilization to Identify Modulators of Uterine Contractility. PLoS ONE. 2015; 10(11): e0143243. PMID: 26600013, PMCID: PMC4658040, PII: PONE-D-15-12311, DOI: 10.1371/journal.pone.0143243, ISSN: 1932-6203.

Lei W, Ni H, Herington J, Reese J, Paria BC. Alkaline phosphatase protects lipopolysaccharide-induced early pregnancy defects in mice. PLoS ONE. 2015; 10(4): e0123243. PMID: 25910276, PMCID: PMC4409290, PII: PONE-D-15-04551, DOI: 10.1371/journal.pone.0123243, ISSN: 1932-6203.

Lei W, Herington J, Galindo CL, Ding T, Brown N, Reese J, Paria BC. Cross-species transcriptomic approach reveals genes in hamster implantation sites. Reproduction [print-electronic]. 2014 Dec; 148(6): 607-21. PMID: 25252651, PMCID: PMC4230993, PII: REP-14-0388, DOI: 10.1530/REP-14-0388, ISSN: 1741-7899.

El-Khuffash A, Jain A, Corcoran D, Shah PS, Hooper CW, Brown N, Poole SD, Shelton EL, Milne GL, Reese J, McNamara PJ. Efficacy of paracetamol on patent ductus arteriosus closure may be dose dependent: evidence from human and murine studies. Pediatr. Res [print-electronic]. 2014 Sep; 76(3): 238-44. PMID: 24941212, PMCID: PMC4321957, PII: pr201482, DOI: 10.1038/pr.2014.82, ISSN: 1530-0447.

Vucovich MM, Cotton RB, Shelton EL, Goettel JA, Ehinger NJ, Poole SD, Brown N, Wynn JL, Paria BC, Slaughter JC, Clark RH, Rojas MA, Reese J. Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2014 Sep 9/1/2014; 307(5): H732-40. PMID: 24993047, PMCID: PMC4187398, PII: ajpheart.00838.2013, DOI: 10.1152/ajpheart.00838.2013, ISSN: 1522-1539.

O'Brien CM, Vargis E, Paria BC, Bennett KA, Mahadevan-Jansen A, Reese J. Raman spectroscopy provides a noninvasive approach for determining biochemical composition of the pregnant cervix in vivo. Acta Paediatr [print-electronic]. 2014 Jul; 103(7): 715-21. PMID: 24628401, PMCID: PMC4048629, DOI: 10.1111/apa.12630, ISSN: 1651-2227.

Shelton EL, Ector G, Galindo CL, Hooper CW, Brown N, Wilkerson I, Pfaltzgraff ER, Paria BC, Cotton RB, Stoller JZ, Reese J. Transcriptional profiling reveals ductus arteriosus-specific genes that regulate vascular tone. Physiol. Genomics [print-electronic]. 2014 Jul 7/1/2014; 46(13): 457-66. PMID: 24790087, PMCID: PMC4080279, PII: physiolgenomics.00171.2013, DOI: 10.1152/physiolgenomics.00171.2013, ISSN: 1531-2267.

Clyman RI, Wickremasinghe A, Merritt TA, Solomon T, McNamara P, Jain A, Singh J, Chu A, Noori S, Sekar K, Lavoie PM, Attridge JT, Swanson JR, Gillam-Krakauer M, Reese J, DeMauro S, Poindexter B, Aucott S, Satpute M, Fernandez E, Auchus RJ, . Hypotension following patent ductus arteriosus ligation: the role of adrenal hormones. J. Pediatr [print-electronic]. 2014 Jun; 164(6): 1449-55.e1. PMID: 24636853, PMCID: PMC4035426, PII: S0022-3476(14)00086-9, DOI: 10.1016/j.jpeds.2014.01.058, ISSN: 1097-6833.

McKnight K, Hoang HD, Prasain JK, Brown N, Vibbert J, Hollister KA, Moore R, Ragains JR, Reese J, Miller MA. Neurosensory perception of environmental cues modulates sperm motility critical for fertilization. Science. 2014 May 5/16/2014; 344(6185): 754-7. PMID: 24833393, PMCID: PMC4094289, PII: science.1250598, DOI: 10.1126/science.1250598, ISSN: 1095-9203.

Huang TK, Reese J, Weitkamp JH, Stancombe BB. Congenital radiocontrast agent in the neonatal gut. J. Pediatr [print-electronic]. 2014 May; 164(5): 1236-1236.e1. PMID: 24534573, PII: S0022-3476(14)00025-0, DOI: 10.1016/j.jpeds.2014.01.019, ISSN: 1097-6833.

Pfaltzgraff ER, Shelton EL, Galindo CL, Nelms BL, Hooper CW, Poole SD, Labosky PA, Bader DM, Reese J. Embryonic domains of the aorta derived from diverse origins exhibit distinct properties that converge into a common phenotype in the adult. J. Mol. Cell. Cardiol [print-electronic]. 2014 Apr; 69: 88-96. PMID: 24508561, PMCID: PMC4034360, PII: S0022-2828(14)00036-4, DOI: 10.1016/j.yjmcc.2014.01.016, ISSN: 1095-8584.

Yanowitz TD, Reese J, Gillam-Krakauer M, Cochran CM, Jegatheesan P, Lau J, Tran VT, Walsh M, Carey WA, Fujii A, Fabio A, Clyman R. Superior mesenteric artery blood flow velocities following medical treatment of a patent ductus arteriosus. J. Pediatr [print-electronic]. 2014 Mar; 164(3): 661-3. PMID: 24321538, PMCID: PMC4077598, PII: S0022-3476(13)01388-7, DOI: 10.1016/j.jpeds.2013.11.002, ISSN: 1097-6833.

Timmons BC, Reese J, Socrate S, Ehinger N, Paria BC, Milne GL, Akins ML, Auchus RJ, McIntire D, House M, Mahendroo M. Prostaglandins are essential for cervical ripening in LPS-mediated preterm birth but not term or antiprogestin-driven preterm ripening. Endocrinology [print-electronic]. 2014 Jan; 155(1): 287-98. PMID: 24189143, PMCID: PMC3868800, PII: en.2013-1304, DOI: 10.1210/en.2013-1304, ISSN: 1945-7170.

Hermanson DJ, Hartley ND, Gamble-George J, Brown N, Shonesy BC, Kingsley PJ, Colbran RJ, Reese J, Marnett LJ, Patel S. Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation. Nat. Neurosci [print-electronic]. 2013 Sep; 16(9): 1291-8. PMID: 23912944, PMCID: PMC3788575, PII: nn.3480, DOI: 10.1038/nn.3480, ISSN: 1546-1726.

Clyman R, Wickremasinghe A, Jhaveri N, Hassinger DC, Attridge JT, Sanocka U, Polin R, Gillam-Krakauer M, Reese J, Mammel M, Couser R, Mulrooney N, Yanowitz TD, Derrick M, Jegatheesan P, Walsh M, Fujii A, Porta N, Carey WA, Swanson JR, . Enteral feeding during indomethacin and ibuprofen treatment of a patent ductus arteriosus. J. Pediatr [print-electronic]. 2013 Aug; 163(2): 406-11. PMID: 23472765, PMCID: PMC3683087, PII: S0022-3476(13)00132-7, DOI: 10.1016/j.jpeds.2013.01.057, ISSN: 1097-6833.

Shelton EL, Poole SD, Reese J, Bader DM. Omental grafting: a cell-based therapy for blood vessel repair. J Tissue Eng Regen Med [print-electronic]. 2013 Jun; 7(6): 421-33. PMID: 22318999, PMCID: PMC3672266, DOI: 10.1002/term.528, ISSN: 1932-7005.

Cotton RB, Shah LP, Poole SD, Ehinger NJ, Brown N, Shelton EL, Slaughter JC, Baldwin HS, Paria BC, Reese J. Cimetidine-associated patent ductus arteriosus is mediated via a cytochrome P450 mechanism independent of H2 receptor antagonism. J. Mol. Cell. Cardiol [print-electronic]. 2013 Jun; 59: 86-94. PMID: 23454087, PMCID: PMC3646934, PII: S0022-2828(13)00067-9, DOI: 10.1016/j.yjmcc.2013.02.010, ISSN: 1095-8584.

Ryckman KK, Dagle JM, Shchelochkov OA, Ehinger N, Poole SD, Berberich SL, Reese J, Murray JC. Association of amino acids with common complications of prematurity. Pediatr. Res [print-electronic]. 2013 Jun; 73(6): 700-5. PMID: 23481552, PMCID: PMC3660469, PII: pr201343, DOI: 10.1038/pr.2013.43, ISSN: 1530-0447.

Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2): S12-6. PMID: 23607856, PMCID: PMC3955361, DOI: 10.1513/AnnalsATS.201207-036OT, ISSN: 2325-6621.

Lei W, Nguyen H, Brown N, Ni H, Kiffer-Moreira T, Reese J, Millán JL, Paria BC. Alkaline phosphatases contribute to uterine receptivity, implantation, decidualization, and defense against bacterial endotoxin in hamsters. Reproduction [electronic-print]. 2013; 146(5): 419-32. PMID: 23929901, PMCID: PMC3805369, PII: REP-13-0153, DOI: 10.1530/REP-13-0153, ISSN: 1741-7899.

Cotton R, Suarez S, Reese J. Unexpected extra-renal effects of loop diuretics in the preterm neonate. Acta Paediatr [print-electronic]. 2012 Aug; 101(8): 835-45. PMID: 22536874, PMCID: PMC3396710, DOI: 10.1111/j.1651-2227.2012.02699.x, ISSN: 1651-2227.

Vargis E, Brown N, Williams K, Al-Hendy A, Paria BC, Reese J, Mahadevan-Jansen A. Detecting biochemical changes in the rodent cervix during pregnancy using Raman spectroscopy. Ann Biomed Eng [print-electronic]. 2012 Aug; 40(8): 1814-24. PMID: 22411265, PMCID: PMC3739433, DOI: 10.1007/s10439-012-0541-4, ISSN: 1573-9686.

Chen JX, O'Mara PW, Poole SD, Brown N, Ehinger NJ, Slaughter JC, Paria BC, Aschner JL, Reese J. Isoprostanes as physiological mediators of transition to newborn life: novel mechanisms regulating patency of the term and preterm ductus arteriosus. Pediatr. Res. 2012 Aug; 72(2): 122-8. PMID: 22565502, PMCID: PMC3586272, PII: pr201258, DOI: 10.1038/pr.2012.58, ISSN: 1530-0447.

Stoller JZ, Demauro SB, Dagle JM, Reese J. Current Perspectives on Pathobiology of the Ductus Arteriosus. J Clin Exp Cardiolog. 2012 Jun 6/15/2012; 8(1): PMID: 23519783, PMCID: PMC3601484, DOI: 10.4172/2155-9880.S8-001, ISSN: 2155-9880.

Peterson JA, Pechauer SM, Gitter ML, Kanack A, Curtis BR, Reese J, Kamath VM, McFarland JG, Aster RH. New platelet glycoprotein polymorphisms causing maternal immunization and neonatal alloimmune thrombocytopenia. Transfusion [print-electronic]. 2012 May; 52(5): 1117-24. PMID: 22070736, PMCID: PMC3564505, DOI: 10.1111/j.1537-2995.2011.03428.x, ISSN: 1537-2995.

Reese J. Patent ductus arteriosus: mechanisms and management. Semin. Perinatol. 2012 Apr; 36(2): 89-91. PMID: 22414878, PII: S0146-0005(11)00163-7, DOI: 10.1053/j.semperi.2011.09.017, ISSN: 1558-075X.

Johnston PG, Gillam-Krakauer M, Fuller MP, Reese J. Evidence-based use of indomethacin and ibuprofen in the neonatal intensive care unit. Clin Perinatol [print-electronic]. 2012 Mar; 39(1): 111-36. PMID: 22341541, PMCID: PMC3598606, PII: S0095-5108(11)00129-1, DOI: 10.1016/j.clp.2011.12.002, ISSN: 1557-9840.

Chen JX, Zeng H, Reese J, Aschner JL, Meyrick B. Overexpression of angiopoietin-2 impairs myocardial angiogenesis and exacerbates cardiac fibrosis in the diabetic db/db mouse model. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2012 Feb 2/15/2012; 302(4): H1003-12. PMID: 22180648, PMCID: PMC3322731, PII: ajpheart.00866.2011, DOI: 10.1152/ajpheart.00866.2011, ISSN: 1522-1539.

Vucovich M, Ehinger N, Poole SD, Lamb FS, Reese J. Spontaneous Rhythmic Contractions (Vasomotion) of the Isolated, Pressurized Ductus Arteriosus of Preterm, but Not Term, Fetal Mice. EJ Neonatol Res. 2012 Jan; 2(1): 13-24. PMID: 23710420, PMCID: PMC3661283, ISSN: 2160-6072.

Luan L, Ding T, Stinnett A, Reese J, Paria BC. Adherens junction proteins in the hamster uterus: their contributions to the success of implantation. Biol. Reprod [print-electronic]. 2011 Nov; 85(5): 996-1004. PMID: 21753191, PMCID: PMC3197917, PII: biolreprod.110.090126, DOI: 10.1095/biolreprod.110.090126, ISSN: 1529-7268.

Uddin MJ, Crews BC, Ghebreselasie K, Huda I, Kingsley PJ, Ansari MS, Tantawy MN, Reese J, Marnett LJ. Fluorinated COX-2 inhibitors as agents in PET imaging of inflammation and cancer. Cancer Prev Res (Phila) [print-electronic]. 2011 Oct; 4(10): 1536-45. PMID: 21900596, PMCID: PMC3214660, PII: 1940-6207.CAPR-11-0120, DOI: 10.1158/1940-6207.CAPR-11-0120, ISSN: 1940-6215.

McElroy SJ, Prince LS, Weitkamp JH, Reese J, Slaughter JC, Polk DB. Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2011 Oct; 301(4): G656-66. PMID: 21737776, PMCID: PMC3191555, PII: ajpgi.00550.2010, DOI: 10.1152/ajpgi.00550.2010, ISSN: 1522-1547.

Wang H, Luan L, Ding T, Brown N, Reese J, Paria BC. Dynamics of zonula occludens-2 expression during preimplantation embryonic development in the hamster. Theriogenology [print-electronic]. 2011 Sep 9/1/2011; 76(4): 678-86. PMID: 21601268, PMCID: PMC3151312, PII: S0093-691X(11)00158-0, DOI: 10.1016/j.theriogenology.2011.03.021, ISSN: 1879-3231.

Reese J, Veldman A, Shah L, Vucovich M, Cotton RB. Inadvertent relaxation of the ductus arteriosus by pharmacologic agents that are commonly used in the neonatal period. Semin. Perinatol. 2010 Jun; 34(3): 222-30. PMID: 20494739, PMCID: PMC2920501, PII: S0146-0005(10)00021-2, DOI: 10.1053/j.semperi.2010.02.007, ISSN: 1558-075X.

Brown N, Morrow JD, Slaughter JC, Paria BC, Reese J. Restoration of on-time embryo implantation corrects the timing of parturition in cytosolic phospholipase A2 group IVA deficient mice. Biol. Reprod [print-electronic]. 2009 Dec; 81(6): 1131-8. PMID: 19684335, PMCID: PMC2802236, PII: biolreprod.109.079061, DOI: 10.1095/biolreprod.109.079061, ISSN: 1529-7268.

Reese J, Waleh N, Poole SD, Brown N, Roman C, Clyman RI. Chronic in utero cyclooxygenase inhibition alters PGE2-regulated ductus arteriosus contractile pathways and prevents postnatal closure. Pediatr. Res. 2009 Aug; 66(2): 155-61. PMID: 19390487, PMCID: PMC3066019, DOI: 10.1203/PDR.0b013e3181aa07eb, ISSN: 1530-0447.

Reese J, O'Mara PW, Poole SD, Brown N, Tolentino C, Eckman DM, Aschner JL. Regulation of the fetal mouse ductus arteriosus is dependent on interaction of nitric oxide and COX enzymes in the ductal wall. Prostaglandins Other Lipid Mediat [print-electronic]. 2009 Apr; 88(3-4): 89-96. PMID: 19049898, PMCID: PMC2813040, PII: S1098-8823(08)00084-1, DOI: 10.1016/j.prostaglandins.2008.11.001, ISSN: 1098-8823.

Waleh N, Reese J, Kajino H, Roman C, Seidner S, McCurnin D, Clyman RI. Oxygen-induced tension in the sheep ductus arteriosus: effects of gestation on potassium and calcium channel regulation. Pediatr. Res. 2009 Mar; 65(3): 285-90. PMID: 19092721, PMCID: PMC2692833, DOI: 10.1203/PDR.0b013e31819746a1, ISSN: 1530-0447.

Pyle AL, Atkinson JB, Pozzi A, Reese J, Eckes B, Davidson JM, Crimmins DL, Young PP. Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction. Am. J. Pathol [print-electronic]. 2008 Nov; 173(5): 1577-88. PMID: 18832573, PMCID: PMC2570146, PII: S0002-9440(10)61542-8, DOI: 10.2353/ajpath.2008.080042, ISSN: 1525-2191.

Wang H, Ding T, Brown N, Yamamoto Y, Prince LS, Reese J, Paria BC. Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev. Biol [print-electronic]. 2008 Jun 6/1/2008; 318(1): 112-25. PMID: 18423437, PMCID: PMC2442465, PII: S0012-1606(08)00212-1, DOI: 10.1016/j.ydbio.2008.03.008, ISSN: 1095-564X.

Reese J, Wang H, Ding T, Paria BC. The hamster as a model for embryo implantation: insights into a multifaceted process. Semin. Cell Dev. Biol [print-electronic]. 2008 Apr; 19(2): 194-203. PMID: 18178492, PMCID: PMC2288742, PII: S1084-9521(07)00194-2, DOI: 10.1016/j.semcdb.2007.11.001, ISSN: 1084-9521.

Frank DB, Lowery J, Anderson L, Brink M, Reese J, de Caestecker M. Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2008 Jan; 294(1): L98-109. PMID: 18024717, PII: 00034.2007, DOI: 10.1152/ajplung.00034.2007, ISSN: 1040-0605.

Tan X, Essengue S, Talreja J, Reese J, Stechschulte DJ, Dileepan KN. Histamine directly and synergistically with lipopolysaccharide stimulates cyclooxygenase-2 expression and prostaglandin I(2) and E(2) production in human coronary artery endothelial cells. J. Immunol. 2007 Dec 12/1/2007; 179(11): 7899-906. PMID: 18025237, PMCID: PMC2597490, PII: 179/11/7899, ISSN: 0022-1767.

Reese J, Anderson JD, Brown N, Roman C, Clyman RI. Inhibition of cyclooxygenase isoforms in late- but not midgestation decreases contractility of the ductus arteriosus and prevents postnatal closure in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2006 Dec; 291(6): R1717-1723. PMID: 16857891, PMCID: PMC2819844, PII: 00259.2006, DOI: 10.1152/ajpregu.00259.2006, ISSN: 0363-6119.

Khatua A, Wang X, Ding T, Zhang Q, Reese J, DeMayo FJ, Paria BC. Indian hedgehog, but not histidine decarboxylase or amphiregulin, is a progesterone-regulated uterine gene in hamsters. Endocrinology [print-electronic]. 2006 Sep; 147(9): 4079-92. PMID: 16794005, PII: en.2006-0231, DOI: 10.1210/en.2006-0231, ISSN: 0013-7227.

Reese J. Death, dying, and exhaustion in the ductus arteriosus: prerequisites for permanent closure [editorial]. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006 Feb; 290(2): R357-8. PMID: 16400037, PII: 290/2/R357, DOI: 10.1152/ajpregu.00749.2005, ISSN: 0363-6119.

Babaev VR, Ding L, Reese J, Morrow JD, Breyer MD, Dey SK, Fazio S, Linton MF. Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice. Circulation [print-electronic]. 2006 Jan 1/3/2006; 113(1): 108-17. PMID: 16380543, PII: CIRCULATIONAHA.105.591537, DOI: 10.1161/CIRCULATIONAHA.105.591537, ISSN: 1524-4539.

Deb K, Reese J, Paria BC. Methodologies to study implantation in mice. Methods Mol. Med. 2006; 121: 9-34. PMID: 16251731, PII: 1-59259-983-4:007, ISSN: 1543-1894.

Anderson J, Brown N, Mahendroo MS, Reese J. Utilization of different aquaporin water channels in the mouse cervix during pregnancy and parturition and in models of preterm and delayed cervical ripening. Endocrinology [print-electronic]. 2006 Jan; 147(1): 130-40. PMID: 16179408, PII: en.2005-0896, DOI: 10.1210/en.2005-0896, ISSN: 0013-7227.

Brown N, Deb K, Paria BC, Das SK, Reese J. Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse. Biol. Reprod [print-electronic]. 2004 Dec; 71(6): 2003-11. PMID: 15306553, PII: biolreprod.104.031864, DOI: 10.1095/biolreprod.104.031864, ISSN: 0006-3363.

Richard C, Gao J, LaFleur B, Christman BW, Anderson J, Brown N, Reese J. Patency of the preterm fetal ductus arteriosus is regulated by endothelial nitric oxide synthase and is independent of vasa vasorum in the mouse. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2004 Sep; 287(3): R652-60. PMID: 15142832, PII: 00049.2004, DOI: 10.1152/ajpregu.00049.2004, ISSN: 0363-6119.

McElroy SJ, Pietsch JB, Reese J. Foley catheter tamponade of intercostal hemorrhage in preterm infants. J. Pediatr. 2004 Aug; 145(2): 241. PMID: 15289776, PII: S0022-3476(04)00061-7, DOI: 10.1016/j.jpeds.2004.01.027, ISSN: 0022-3476.

Wang X, Su Y, Deb K, Raposo M, Morrow JD, Reese J, Paria BC. Prostaglandin E2 is a product of induced prostaglandin-endoperoxide synthase 2 and microsomal-type prostaglandin E synthase at the implantation site of the hamster. J. Biol. Chem [print-electronic]. 2004 Jul 7/16/2004; 279(29): 30579-87. PMID: 15078866, PII: M400573200, DOI: 10.1074/jbc.M400573200, ISSN: 0021-9258.

Dey SK, Lim H, Das SK, Reese J, Paria BC, Daikoku T, Wang H. Molecular cues to implantation. Endocr. Rev. 2004 Jun; 25(3): 341-73. PMID: 15180948, PII: 25/3/341, DOI: 10.1210/er.2003-0020, ISSN: 0163-769X.

Gao L, Zackert WE, Hasford JJ, Danekis ME, Milne GL, Remmert C, Reese J, Yin H, Tai HH, Dey SK, Porter NA, Morrow JD. Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase. J. Biol. Chem [print-electronic]. 2003 Aug 8/1/2003; 278(31): 28479-89. PMID: 12746435, PII: M303984200, DOI: 10.1074/jbc.M303984200, ISSN: 0021-9258.

Richard C, Gao J, Brown N, Reese J. Aquaporin water channel genes are differentially expressed and regulated by ovarian steroids during the periimplantation period in the mouse. Endocrinology. 2003 Apr; 144(4): 1533-41. PMID: 12639938, DOI: 10.1210/en.2002-0033, ISSN: 0013-7227.

Paria BC, Reese J, Das SK, Dey SK. Deciphering the cross-talk of implantation: advances and challenges. Science. 2002 Jun 6/21/2002; 296(5576): 2185-8. PMID: 12077405, PII: 296/5576/2185, DOI: 10.1126/science.1071601, ISSN: 1095-9203.

Lim H, Song H, Paria BC, Reese J, Das SK, Dey SK. Molecules in blastocyst implantation: uterine and embryonic perspectives. Vitam. Horm. 2002; 64: 43-76. PMID: 11898397, ISSN: 0083-6729.

Reese J, Das SK, Paria BC, Lim H, Song H, Matsumoto H, Knudtson KL, DuBois RN, Dey SK. Global gene expression analysis to identify molecular markers of uterine receptivity and embryo implantation. J. Biol. Chem [print-electronic]. 2001 Nov 11/23/2001; 276(47): 44137-45. PMID: 11551965, PII: M107563200, DOI: 10.1074/jbc.M107563200, ISSN: 0021-9258.

Reese J, Zhao X, Ma WG, Brown N, Maziasz TJ, Dey SK. Comparative analysis of pharmacologic and/or genetic disruption of cyclooxygenase-1 and cyclooxygenase-2 function in female reproduction in mice. Endocrinology. 2001 Jul; 142(7): 3198-206. PMID: 11416042, DOI: 10.1210/endo.142.7.8307, ISSN: 0013-7227.

Reese J, Paria BC, Brown N, Zhao X, Morrow JD, Dey SK. Coordinated regulation of fetal and maternal prostaglandins directs successful birth and postnatal adaptation in the mouse. Proc. Natl. Acad. Sci. U.S.A. 2000 Aug 8/15/2000; 97(17): 9759-64. PMID: 10944235, PMCID: PMC16938, PII: 97/17/9759, ISSN: 0027-8424.

Williams CS, Tsujii M, Reese J, Dey SK, DuBois RN. Host cyclooxygenase-2 modulates carcinoma growth. J. Clin. Invest. 2000 Jun; 105(11): 1589-94. PMID: 10841517, PMCID: PMC300858, DOI: 10.1172/JCI9621, ISSN: 0021-9738.

Reese J, Binart N, Brown N, Ma WG, Paria BC, Das SK, Kelly PA, Dey SK. Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR. Endocrinology. 2000 May; 141(5): 1872-81. PMID: 10803598, DOI: 10.1210/endo.141.5.7464, ISSN: 0013-7227.

Paria BC, Lim H, Das SK, Reese J, Dey SK. Molecular signaling in uterine receptivity for implantation. Semin. Cell Dev. Biol. 2000 Apr; 11(2): 67-76. PMID: 10873704, PII: S1084-9521(00)90153-8, DOI: 10.1006/scdb.2000.0153, ISSN: 1084-9521.

Reese J, Brown N, Paria BC, Morrow J, Dey SK. COX-2 compensation in the uterus of COX-1 deficient mice during the pre-implantation period. Mol. Cell. Endocrinol. 1999 Apr 4/25/1999; 150(1-2): 23-31. PMID: 10411296, ISSN: 0303-7207.

Reese J, Brown N, Das SK, Dey SK. Expression of neu differentiation factor during the periimplantation period in the mouse uterus. Biol. Reprod. 1998 Mar; 58(3): 719-27. PMID: 9510959, ISSN: 0006-3363.

Reese J, Raghuveer TS, Dennington PM, Barfield CP. Breast feeding in neonatal alloimmune thrombocytopenia. J Paediatr Child Health. 1994 Oct; 30(5): 447-9. PMID: 7833086, ISSN: 1034-4810.

Reese J, Prentice G, Yu VY. Dose conversion from aminophylline to theophylline in preterm infants. Arch. Dis. Child. Fetal Neonatal Ed. 1994 Jul; 71(1): F51-2. PMID: 8092873, PMCID: PMC1061070, ISSN: 1359-2998.