R. Daniel Beauchamp, M.D.

Professor

daniel.beauchamp@vanderbilt.edu
Faculty Appointments
Chair of the Section of Surgical Sciences Professor of Surgery John Clinton Foshee Distinguished Chair in SurgeryAdjunct Professor of Surgery at Meharry Medical CollegeProfessor of Cell and Developmental BiologyProfessor of Cancer Biology
Education
M.D., Medicine, University of Texas, Dallas, TexasB.S., Mircrobiology, Texas Tech University, Lubbock, Texas
Office Address
D-4316 MCN
TN 2730
Research Description
R. Daniel Beauchamp, MD, is the John Clinton Foshee Distinguished Professor of Surgery, Chairman of the Section of Surgical Sciences, and Surgeon-in-Chief of Vanderbilt University Hospital and has held these positions since July 2001 and on the faculty at Vanderbilt since December 1994. He holds joint appointments as professor in the departments of Cell and Developmental Biology and Cancer Biology. He also serves as Deputy Director of the Vanderbilt-Ingram Cancer Center. Dr. Beauchamp has two active R01 grants from NIH, and leads one of the main projects in the GI Cancer SPORE. Dr. Beauchamp's primary area of research interest has been in colorectal carcinogenesis, the biology of cancer cell invasion and metastasis, and in the identification of novel molecular biomarkers and therapeutic targets in colorectal and other alimentary tract malignancies. His work applies DNA microarray and proteomic technology to identify novel biomarkers and therapeutic targets in human colorectal cancer samples. He also uses molecular genetics, chemical biology and cell biological approaches to examine mechanistic questions in cancer biology in both cell culture and mouse models. In addition to the basic cancer research Dr. Beauchamp works in collaboration with his Medical Oncology and Radiation Oncology colleagues to accrue cancer patients to approved clinical trials. He has trained and mentored numerous junior faculty members, physician scientist fellows, medical students, graduate students and post-doctoral fellows in his laboratory. He is one of the few surgeon members of the ASCI.
Research Keywords
Transforming growth factor, Gastrointestinal carcinogenesis, Ras oncogene, colon cancer, epithelial to mesenchymal transition, metastasis, mouse models
Clinical Research Keywords
Breast</A>, Colorectal, Esophageal, Liver, Melanoma, Pancreatic, Soft-Tissue and Bone Sarcoma, "><A HREF="http://www.vicc.org/cancerinfo/breast.html">Breast</A>, Colorectal, Esophageal, Liver, Melanoma, Pancreatic, Soft-Tissue and Bone Sarcoma,
Publications
Hanson AJ, Wallace HA, Freeman TJ, Beauchamp RD, Lee LA, Lee E. XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. Mol. Cell [print-electronic]. 2012 Mar 3/9/2012; 45(5): 619-28. PMID: 22304967, PMCID: PMC3299836, PII: S1097-2765(12)00042-1, DOI: 10.1016/j.molcel.2011.12.032, ISSN: 1097-4164.

Freeman TJ, Smith JJ, Chen X, Washington MK, Roland JT, Means AL, Eschrich SA, Yeatman TJ, Deane NG, Beauchamp RD. Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of ß-catenin. Gastroenterology [print-electronic]. 2012 Mar; 142(3): 562-571.e2. PMID: 22115830, PMCID: PMC3343368, PII: S0016-5085(11)01622-2, DOI: 10.1053/j.gastro.2011.11.026, ISSN: 1528-0012.

Singh AB, Sharma A, Smith JJ, Krishnan M, Chen X, Eschrich S, Washington MK, Yeatman TJ, Beauchamp RD, Dhawan P. Claudin-1 up-regulates the repressor ZEB-1 to inhibit E-cadherin expression in colon cancer cells. Gastroenterology [print-electronic]. 2011 Dec; 141(6): 2140-53. PMID: 21878201, PMCID: PMC3395068, PII: S0016-5085(11)01221-2, DOI: 10.1053/j.gastro.2011.08.038, ISSN: 1528-0012.

Williams CS, Zhang B, Smith JJ, Jayagopal A, Barrett CW, Pino C, Russ P, Presley SH, Peng D, Rosenblatt DO, Haselton FR, Yang JL, Washington MK, Chen X, Eschrich S, Yeatman TJ, El-Rifai W, Beauchamp RD, Chang MS. BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma. J. Clin. Invest [print-electronic]. 2011 Oct; 121(10): 4056-69. PMID: 21911938, PMCID: PMC3195453, PII: 44228, DOI: 10.1172/JCI44228, ISSN: 1558-8238.

Dhawan P, Ahmad R, Chaturvedi R, Smith JJ, Midha R, Mittal MK, Krishnan M, Chen X, Eschrich S, Yeatman TJ, Harris RC, Washington MK, Wilson KT, Beauchamp RD, Singh AB. Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Oncogene [print-electronic]. 2011 Jul 7/21/2011; 30(29): 3234-47. PMID: 21383692, PMCID: PMC3591522, PII: onc201143, DOI: 10.1038/onc.2011.43, ISSN: 1476-5594.

Kauffmann RM, Landman MP, Shelton J, Dmochowski RR, Bledsoe SH, Hickson GB, Beauchamp RD, Dattilo JB. The use of a multidisciplinary morbidity and mortality conference to incorporate ACGME general competencies. J Surg Educ [print-electronic]. 2011 Jul; 68(4): 303-8. PMID: 21708368, PMCID: PMC3128423, PII: S1931-7204(11)00051-1, DOI: 10.1016/j.jsurg.2011.02.002, ISSN: 1878-7452.

Stoops SL, Pearson AS, Weaver C, Waterson AG, Days E, Farmer C, Brady S, Weaver CD, Beauchamp RD, Lindsley CW. Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells. ACS Chem. Biol [print-electronic]. 2011 May 5/20/2011; 6(5): 452-65. PMID: 21241068, PMCID: PMC3401128, DOI: 10.1021/cb100305h, ISSN: 1554-8937.

Lapierre LA, Caldwell CM, Higginbotham JN, Avant KM, Hall J, Beauchamp RD, Goldenring JR. Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent. Cytoskeleton (Hoboken) [print-electronic]. 2011 Feb; 68(2): 97-111. PMID: 21246754, PMCID: PMC3885764, DOI: 10.1002/cm.20497, ISSN: 1949-3592.

Nam KT, Lee HJ, Smith JJ, Lapierre LA, Kamath VP, Chen X, Aronow BJ, Yeatman TJ, Bhartur SG, Calhoun BC, Condie B, Manley NR, Beauchamp RD, Coffey RJ, Goldenring JR. Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J. Clin. Invest [print-electronic]. 2010 Mar; 120(3): 840-9. PMID: 20197623, PMCID: PMC2827957, PII: 40728, DOI: 10.1172/JCI40728, ISSN: 1558-8238.

Smith JJ, Deane NG, Wu F, Merchant NB, Zhang B, Jiang A, Lu P, Johnson JC, Schmidt C, Bailey CE, Eschrich S, Kis C, Levy S, Washington MK, Heslin MJ, Coffey RJ, Yeatman TJ, Shyr Y, Beauchamp RD. Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. Gastroenterology [print-electronic]. 2010 Mar; 138(3): 958-68. PMID: 19914252, PMCID: PMC3388775, PII: S0016-5085(09)01964-7, DOI: 10.1053/j.gastro.2009.11.005, ISSN: 1528-0012.

Krishnan M, Singh AB, Smith JJ, Sharma A, Chen X, Eschrich S, Yeatman TJ, Beauchamp RD, Dhawan P. HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability. Oncogene [print-electronic]. 2010 Jan 1/14/2010; 29(2): 305-12. PMID: 19881542, PMCID: PMC3388773, PII: onc2009324, DOI: 10.1038/onc.2009.324, ISSN: 1476-5594.

Xu BJ, Li J, Beauchamp RD, Shyr Y, Li M, Washington MK, Yeatman TJ, Whitehead RH, Coffey RJ, Caprioli RM. Identification of early intestinal neoplasia protein biomarkers using laser capture microdissection and MALDI MS. Mol. Cell Proteomics [print-electronic]. 2009 May; 8(5): 936-45. PMID: 19164278, PMCID: PMC2689774, PII: M800345-MCP200, DOI: 10.1074/mcp.M800345-MCP200, ISSN: 1535-9484.

Smith JJ, Deane NG, Dhawan P, Beauchamp RD. Regulation of metastasis in colorectal adenocarcinoma: a collision between development and tumor biology. Surgery [print-electronic]. 2008 Sep; 144(3): 353-66. PMID: 18707034, PMCID: PMC2594010, PII: S0039-6060(08)00316-4, DOI: 10.1016/j.surg.2008.05.007, ISSN: 1532-7361.

Kanies CL, Smith JJ, Kis C, Schmidt C, Levy S, Khabar KS, Morrow J, Deane N, Dixon DA, Beauchamp RD. Oncogenic Ras and transforming growth factor-beta synergistically regulate AU-rich element-containing mRNAs during epithelial to mesenchymal transition. Mol. Cancer Res. 2008 Jul; 6(7): 1124-36. PMID: 18644977, PMCID: PMC2572152, PII: 6/7/1124, DOI: 10.1158/1541-7786.MCR-07-2095, ISSN: 1541-7786.

Li JQ, Xu BJ, Shakhtour B, Deane N, Merchant N, Heslin MJ, Washington K, Coffey RJ, Beauchamp RD, Shyr Y, Billheimer D. Variability of in situ proteomic profiling and implications for study design in colorectal tumors. Int. J. Oncol. 2007 Jul; 31(1): 103-11. PMID: 17549410, ISSN: 1019-6439.

Shiou SR, Singh AB, Moorthy K, Datta PK, Washington MK, Beauchamp RD, Dhawan P. Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells. Cancer Res. 2007 Feb 2/15/2007; 67(4): 1571-9. PMID: 17308096, PII: 67/4/1571, DOI: 10.1158/0008-5472.CAN-06-1680, ISSN: 0008-5472.

Kim DW, Blanke CD, Wu H, Shyr Y, Berlin J, Beauchamp RD, Chakravarthy B. Phase II study of preoperative paclitaxel/cisplatin with radiotherapy in locally advanced esophageal cancer. Int. J. Radiat. Oncol. Biol. Phys [print-electronic]. 2007 Feb 2/1/2007; 67(2): 397-404. PMID: 17097833, PII: S0360-3016(06)02837-9, DOI: 10.1016/j.ijrobp.2006.08.062, ISSN: 0360-3016.

Shiou SR, Datta PK, Dhawan P, Law BK, Yingling JM, Dixon DA, Beauchamp RD. Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta. J. Biol. Chem [print-electronic]. 2006 Nov 11/10/2006; 281(45): 33971-81. PMID: 16959768, PII: M607010200, DOI: 10.1074/jbc.M607010200, ISSN: 0021-9258.

Johnson JC, Schmidt CR, Shrubsole MJ, Billheimer DD, Joshi PR, Morrow JD, Heslin MJ, Washington MK, Ness RM, Zheng W, Schwartz DA, Coffey RJ, Beauchamp RD, Merchant NB. Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Clin. Gastroenterol. Hepatol [print-electronic]. 2006 Nov; 4(11): 1358-65. PMID: 16996805, PII: S1542-3565(06)00772-5, DOI: 10.1016/j.cgh.2006.07.015, ISSN: 1542-3565.

Halder SK, Anumanthan G, Maddula R, Mann J, Chytil A, Gonzalez AL, Washington MK, Moses HL, Beauchamp RD, Datta PK. Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis. Cancer Res. 2006 Jun 6/15/2006; 66(12): 6156-66. PMID: 16778189, PII: 66/12/6156, DOI: 10.1158/0008-5472.CAN-05-3261, ISSN: 0008-5472.

Chakravarthy AB, Kelley MC, McLaren B, Truica CI, Billheimer D, Mayer IA, Grau AM, Johnson DH, Simpson JF, Beauchamp RD, Jones C, Pietenpol JA. Neoadjuvant concurrent paclitaxel and radiation in stage II/III breast cancer. Clin. Cancer Res. 2006 Mar 3/1/2006; 12(5): 1570-6. PMID: 16533783, PII: 12/5/1570, DOI: 10.1158/1078-0432.CCR-05-2304, ISSN: 1078-0432.

Deane NG, Parker MA, Beauchamp RD. Cell proliferation: a matter of time and place. Surgery. 2005 Jul; 138(1): 1-7. PMID: 16003308, PII: S0039606004007287, DOI: 10.1016/j.surg.2004.12.006, ISSN: 0039-6060.

Dhawan P, Singh AB, Deane NG, No Y, Shiou SR, Schmidt C, Neff J, Washington MK, Beauchamp RD. Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J. Clin. Invest [print-electronic]. 2005 Jul; 115(7): 1765-76. PMID: 15965503, PMCID: PMC1150288, DOI: 10.1172/JCI24543, ISSN: 0021-9738.

Halder SK, Beauchamp RD, Datta PK. Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis. Exp. Cell Res [print-electronic]. 2005 Jul 7/1/2005; 307(1): 231-46. PMID: 15922743, PII: S0014-4827(05)00115-1, DOI: 10.1016/j.yexcr.2005.03.009, ISSN: 0014-4827.

Poulose BK, Ray WA, Arbogast PG, Needleman J, Buerhaus PI, Griffin MR, Abumrad NN, Beauchamp RD, Holzman MD. Resident work hour limits and patient safety. Ann. Surg. 2005 Jun; 241(6): 847-56; discussion 856. PMID: 15912034, PMCID: PMC1357165, PII: 00000658-200506000-00002, ISSN: 0003-4932.

Halder SK, Beauchamp RD, Datta PK. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia. 2005 May; 7(5): 509-21. PMID: 15967103, PMCID: PMC1501161, ISSN: 1522-8002.

Tedesco KL, Berlin J, Blanke CD, Teng M, Choy H, Roberts J, Beauchamp RD, Leach S, Wyman K, Tarpley J, Shyr Y, Caillouette C, Chakravarthy B. Phase I trial of Orzel (UFT plus leucovorin), cisplatin, and radiotherapy in the treatment of potentially resectable esophageal cancer. Int. J. Radiat. Oncol. Biol. Phys. 2005 Apr 4/1/2005; 61(5): 1364-70. PMID: 15817338, PII: S0360-3016(04)02471-X, DOI: 10.1016/j.ijrobp.2004.08.050, ISSN: 0360-3016.

Beauchamp RD. The changing roles of a surgical department chair: adapting to a changing environment. Arch Surg. 2005 Mar; 140(3): 258-63. PMID: 15781789, PII: 140/3/258, DOI: 10.1001/archsurg.140.3.258, ISSN: 0004-0010.

Lawson LL, Sandler M, Martin W, Beauchamp RD, Kelley MC. Preoperative lymphoscintigraphy and internal mammary sentinel lymph node biopsy do not enhance the accuracy of lymphatic mapping for breast cancer. Am Surg. 2004 Dec; 70(12): 1050-5; discussion 1055. PMID: 15663043, ISSN: 0003-1348.

Beauchamp RD. Department of Surgery, Vanderbilt University Medical Center, Nashville, Tenn. Arch Surg. 2004 Aug; 139(8): 814-5. PMID: 15302687, PII: 139/8/814, DOI: 10.1001/archsurg.139.8.814, ISSN: 0004-0010.

Schmidt CR, Gi YJ, Coffey RJ, Beauchamp RD, Pearson AS. Oncogenic Ras dominates overexpression of E-cadherin in malignant transformation of intestinal epithelial cells. Surgery. 2004 Aug; 136(2): 303-9. PMID: 15300195, PII: S0039606004002442, DOI: 10.1016/j.surg.2004.05.004, ISSN: 0039-6060.

Li JQ, Wu F, Masaki T, Kubo A, Fujita J, Dixon DA, Beauchamp RD, Ishida T, Kuriyama S, Imaida K. Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors. Int. J. Oncol. 2004 Jul; 25(1): 87-95. PMID: 15201993, ISSN: 1019-6439.

Mithani SK, Balch GC, Shiou SR, Whitehead RH, Datta PK, Beauchamp RD. Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells. J. Surg. Res. 2004 Apr; 117(2): 296-305. PMID: 15047135, PII: S0022480403003354, DOI: 10.1016/S0022-4804(03)00335-4, ISSN: 0022-4804.

Deane NG, Lee H, Hamaamen J, Ruley A, Washington MK, LaFleur B, Thorgeirsson SS, Price R, Beauchamp RD. Enhanced tumor formation in cyclin D1 x transforming growth factor beta1 double transgenic mice with characterization by magnetic resonance imaging. Cancer Res. 2004 Feb 2/15/2004; 64(4): 1315-22. PMID: 14973059, ISSN: 0008-5472.

Parker MA, Deane NG, Thompson EA, Whitehead RH, Mithani SK, Washington MK, Datta PK, Dixon DA, Beauchamp RD. Over-expression of cyclin D1 regulates Cdk4 protein synthesis. Cell Prolif. 2003 Dec; 36(6): 347-60. PMID: 14710852, ISSN: 0960-7722.

Schmidt CR, Washington MK, Gi YJ, Coffey RJ, Beauchamp RD, Pearson AS. Dysregulation of E-cadherin by oncogenic Ras in intestinal epithelial cells is blocked by inhibiting MAP kinase. Am. J. Surg. 2003 Nov; 186(5): 426-30. PMID: 14599601, PII: S0002961003003271, ISSN: 0002-9610.

Dixon DA, Balch GC, Kedersha N, Anderson P, Zimmerman GA, Beauchamp RD, Prescott SM. Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1. J. Exp. Med [print-electronic]. 2003 Aug 8/4/2003; 198(3): 475-81. PMID: 12885872, PMCID: PMC2194089, PII: jem.20030616, DOI: 10.1084/jem.20030616, ISSN: 0022-1007.

Balch GC, Mithani SK, Richards KR, Beauchamp RD, Kelley MC. Lymphatic mapping and sentinel lymphadenectomy after preoperative therapy for stage II and III breast cancer. Ann. Surg. Oncol. 2003 Jul; 10(6): 616-21. PMID: 12839845, ISSN: 1068-9265.

Ahmed A, Thompson J, Emiliusen L, Murphy S, Beauchamp RD, Suzuki K, Alemany R, Harrington K, Vile RG. A conditionally replicating adenovirus targeted to tumor cells through activated RAS/P-MAPK-selective mRNA stabilization. Nat. Biotechnol [print-electronic]. 2003 Jul; 21(7): 771-7. PMID: 12794639, PII: nbt835, DOI: 10.1038/nbt835, ISSN: 1087-0156.

Berger DH, O'Mahony CA, Sheng H, Shao J, Albo D, DuBois RN, Beauchamp RD. Intestinal transformation results in transforming growth factor-beta-dependent alteration in tumor cell-cell matrix interactions. Surgery. 2003 May; 133(5): 568-79. PMID: 12773985, PII: S0039606003000291, DOI: 10.1067/msy.2003.125, ISSN: 0039-6060.

Fujimoto K, Beauchamp RD, Whitehead RH. Identification and isolation of candidate human colonic clonogenic cells based on cell surface integrin expression. Gastroenterology. 2002 Dec; 123(6): 1941-8. PMID: 12454851, PII: S0016508502004663, DOI: 10.1053/gast.2002.37065, ISSN: 0016-5085.

Berger DH, Feng XH, Yao J, Saha D, Beauchamp RD, Lin X. Resistance to transforming growth factor-beta occurs in the presence of normal Smad activation. Surgery. 2002 Aug; 132(2): 310-6. PMID: 12219028, PII: S0039606002000892, ISSN: 0039-6060.

Saha D, Roman C, Beauchamp RD. New strategies for colorectal cancer prevention and treatment. World J Surg [print-electronic]. 2002 Jul; 26(7): 762-6. PMID: 11948369, DOI: 10.1007/s00268-002-4049-1, ISSN: 0364-2313.

Roman CD, Choy H, Nanney L, Riordan C, Parman K, Johnson D, Beauchamp RD. Vascular endothelial growth factor-mediated angiogenesis inhibition and postoperative wound healing in rats. J. Surg. Res. 2002 Jun 6/1/2002; 105(1): 43-7. PMID: 12069500, PII: S0022480402964449, DOI: 10.1006/jsre.2002.6444, ISSN: 0022-4804.

Roman CD, Morrow J, Whitehead R, Beauchamp RD. Induction of cyclooxygenase-2 and invasiveness by transforming growth factor-beta(1) in immortalized mouse colonocytes expressing oncogenic Ras. J. Gastrointest. Surg. 2002 May; 6(3): 304-9. PMID: 12022979, PII: S1091255X01000415, ISSN: 1091-255X.

Roman CD, Hanley GA, Beauchamp RD. Operative technique for safe pulmonary lobectomy in Sprague-Dawley rats. Contemp Top Lab Anim Sci. 2002 Mar; 41(2): 28-30. PMID: 11958600, ISSN: 1060-0558.

Saha D, Datta PK, Beauchamp RD. Oncogenic ras represses transforming growth factor-beta /Smad signaling by degrading tumor suppressor Smad4. J. Biol. Chem [print-electronic]. 2001 Aug 8/3/2001; 276(31): 29531-7. PMID: 11371552, PII: M100069200, DOI: 10.1074/jbc.M100069200, ISSN: 0021-9258.

Deane NG, Parker MA, Aramandla R, Diehl L, Lee WJ, Washington MK, Nanney LB, Shyr Y, Beauchamp RD. Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice. Cancer Res. 2001 Jul 7/15/2001; 61(14): 5389-95. PMID: 11454681, ISSN: 0008-5472.

Fujimoto K, Sheng H, Shao J, Beauchamp RD. Transforming growth factor-beta1 promotes invasiveness after cellular transformation with activated Ras in intestinal epithelial cells. Exp. Cell Res. 2001 Jun 6/10/2001; 266(2): 239-49. PMID: 11399052, PII: S0014-4827(00)95229-7, DOI: 10.1006/excr.2000.5229, ISSN: 0014-4827.

Zhang Z, Sheng H, Shao J, Beauchamp RD, DuBois RN. Posttranscriptional regulation of cyclooxygenase-2 in rat intestinal epithelial cells. Neoplasia. 2000 Nov; 2(6): 523-30. PMID: 11228545, PMCID: PMC1508084, ISSN: 1522-8002.

Fujimoto K, Hosotani R, Miyamoto Y, Doi R, Koshiba T, Otaka A, Fujii N, Beauchamp RD, Imamura M. Inhibition of pRb phosphorylation and cell cycle progression by an antennapedia-p16(INK4A) fusion peptide in pancreatic cancer cells. Cancer Lett. 2000 Oct 10/31/2000; 159(2): 151-8. PMID: 10996726, PII: S030438350000536X, ISSN: 0304-3835.

Beauchamp RD. Presidential address: evolution. Surgery. 2000 Aug; 128(2): 123-32. PMID: 10922981, PII: S0039-6060(00)06170-5, DOI: 10.1067/msy.2000.108057, ISSN: 0039-6060.

Shao J, Sheng H, DuBois RN, Beauchamp RD. Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation. J. Biol. Chem. 2000 Jul 7/28/2000; 275(30): 22916-24. PMID: 10781597, PII: M002235200, DOI: 10.1074/jbc.M002235200, ISSN: 0021-9258.

Sheng H, Shao J, Dixon DA, Williams CS, Prescott SM, DuBois RN, Beauchamp RD. Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. J. Biol. Chem. 2000 Mar 3/3/2000; 275(9): 6628-35. PMID: 10692471, ISSN: 0021-9258.

Jo H, Zhang R, Zhang H, McKinsey TA, Shao J, Beauchamp RD, Ballard DW, Liang P. NF-kappa B is required for H-ras oncogene induced abnormal cell proliferation and tumorigenesis. Oncogene. 2000 Feb 2/17/2000; 19(7): 841-9. PMID: 10702792, DOI: 10.1038/sj.onc.1203392, ISSN: 0950-9232.

Sheng, H., Shao, J., Williams, C.S., Prescott, S.M., Dubois, R.N., and Beauchamp, R.D. TGF-1 enhances Ha-Ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. Journal of Biological Chemistry. 2000; 275: 6628-35.

Shao, J., Sheng, H.M., Dubois, R.N., and Beauchamp, R.D. Oncogenic Ras-mediated cell growth arrest and apoptosis is associated with increased ubiquitin-dependent cyclin D1 degradation. Journal of Biological Chemistry. 2000; 275: 22916-24.

Bulus N., Sheng H-M., Sizemore N., Oldham S.M., Barnett J.V., Coffey R.J., Beauchamp R.D. and Barnard J.A. Ras-mediated suppression of TFGRII expression in intestinal pedithelial cells involves a Raf-independent signaling. Neoplasia. 2000; 2((4)): 357-64.

Saha D, Datta PK, Sheng H, Morrow JD, Wada M, Moses HL, Beauchamp RD. Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells. Neoplasia. 1999 Dec; 1(6): 508-17. PMID: 10935498, PMCID: PMC1508120, ISSN: 1522-8002.

Delbeke D, Rose DM, Chapman WC, Pinson CW, Wright JK, Beauchamp RD, Shyr Y, Leach SD. Optimal interpretation of FDG PET in the diagnosis, staging and management of pancreatic carcinoma. J. Nucl. Med. 1999 Nov; 40(11): 1784-91. PMID: 10565771, ISSN: 0161-5505.

Scoggins CR, Meszoely IM, Blanke CD, Beauchamp RD, Leach SD. Nonoperative management of primary colorectal cancer in patients with stage IV disease. Ann. Surg. Oncol. 1999 Oct; 6(7): 651-7. PMID: 10560850, ISSN: 1068-9265.

Rose DM, Delbeke D, Beauchamp RD, Chapman WC, Sandler MP, Sharp KW, Richards WO, Wright JK, Frexes ME, Pinson CW, Leach SD. 18Fluorodeoxyglucose-positron emission tomography in the management of patients with suspected pancreatic cancer. Ann. Surg. 1999 May; 229(5): 729-37; discussion 737. PMID: 10235532, PMCID: PMC1420818, ISSN: 0003-4932.

Shao J, Sheng H, Aramandla R, Pereira MA, Lubet RA, Hawk E, Grogan L, Kirsch IR, Washington MK, Beauchamp RD, DuBois RN. Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. Carcinogenesis. 1999 Feb; 20(2): 185-91. PMID: 10069452, ISSN: 0143-3334.

Sheng H, Shao J, O'Mahony CA, Lamps L, Albo D, Isakson PC, Berger DH, DuBois RN, Beauchamp RD. Transformation of intestinal epithelial cells by chronic TGF-beta1 treatment results in downregulation of the type II TGF-beta receptor and induction of cyclooxygenase-2. Oncogene. 1999 Jan 1/28/1999; 18(4): 855-67. PMID: 10023661, DOI: 10.1038/sj.onc.1202397, ISSN: 0950-9232.

Sheng, H., Shao, J., O'Mahony, C.A., Lamps, L., Albo, D., Isakson, P.C., Berger, D.H., DuBois, R.N., and Beauchamp, R.D. Transformation of intestinal epithelial cells by chronic TGF-b1 treatment results in downregulation of the type II TGF-b receptor and induction of cyclooxygenase-2. Oncogene. 1999; 18: 855-67.

Shao, J., Sheng, H.M., Aramandla, R., Pereira, M.A., Lubet, R.A., Hawk, E., Grogan, L., Kirshc, I.R., Washington, M.K., Beauchamp, R.D. and Dubois, R.N. Coordinate regulation of cyclooxygenase-2 and TGF-1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. Carcinogenesis. 1999; 20((2)): 185-91.

Sheng H, Williams CS, Shao J, Liang P, DuBois RN, Beauchamp RD. Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway. J. Biol. Chem. 1998 Aug 8/21/1998; 273(34): 22120-7. PMID: 9705357, ISSN: 0021-9258.

Chinery R, Beauchamp RD, Shyr Y, Kirkland SC, Coffey RJ, Morrow JD. Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells. Cancer Res. 1998 Jun 6/1/1998; 58(11): 2323-7. PMID: 9622066, ISSN: 0008-5472.

Sheng H, Shao J, Williams CS, Pereira MA, Taketo MM, Oshima M, Reynolds AB, Washington MK, DuBois RN, Beauchamp RD. Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas. Carcinogenesis. 1998 Apr; 19(4): 543-9. PMID: 9600336, ISSN: 0143-3334.

Sheng H, Shao J, Morrow JD, Beauchamp RD, DuBois RN. Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res. 1998 Jan 1/15/1998; 58(2): 362-6. PMID: 9443418, ISSN: 0008-5472.

Sheng, H., Shao,J., Williams, C.S., Pereira, M.A., Taketo, M.M., Oshima, M., Reynolds, A.B., Washington, M.W., DuBois, R.N and Beauchamp, R.D. Nuclear translocation of b-catenin in hereditary and carcinogen- induced intestinal adenomas. Carcinogenesis. 1998; 19: 543-9.

Chinery, R., Beauchamp, R.D., Shyr, Y., Kirkland, S.C., Coffey, R.J., and Morrow, J.D. Antioxidants reduce cyclooxygenase -2 expression, prostaglandin production and proliferation in colorectal cancer cells. Cancer Research. 1998; 58: 2323-7.

Sheng, H., Williams, C.S., Shao, J., Liang, P., DuBois, R.N., and Beauchamp, R.D. Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway. Journal of Biological Chemistry. 1998; 22120-7.

Sheng, H., Shao, J., Morrow, J., Beauchamp, R., DuBois, R. Modulation of Apoptosis and Bcl-2 Expression by Prostaglandin E2 in Human Colon Cancer Cells. Cancer Research. 1998; 58: 362-6.

Ko, T.C., Yu, W., Sakai, T., Sheng, H., Shao, J., Beauchamp, R.D and Thompson, E.A. TGF-b1 effects on proliferation of rat intestinal epithelial cells are due to inhibition of cyclin D1 expression. Oncogene. 1998; 16: 3445-54.

Washington, K., Chiappori, A., Hamilton, K., Yu, S., Blanke, C., johnson, D., Sawyers, J., and Beauchamp, R.D. Expression of -catenin, -catenin, and E-cadherin in Barrett?s esophagus and esophageal adenocarcinomas. Modern Pathology. 1998; 11((9)): 805-13.

Sheng GG, Shao J, Sheng H, Hooton EB, Isakson PC, Morrow JD, Coffey RJ, DuBois RN, Beauchamp RD. A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells. Gastroenterology. 1997 Dec; 113(6): 1883-91. PMID: 9394727, PII: S0016508597005556, ISSN: 0016-5085.

Chinery R, Brockman JA, Peeler MO, Shyr Y, Beauchamp RD, Coffey RJ. Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPbeta. Nat. Med. 1997 Nov; 3(11): 1233-41. PMID: 9359698, ISSN: 1078-8956.

Sheng H, Shao J, Kirkland SC, Isakson P, Coffey RJ, Morrow J, Beauchamp RD, DuBois RN. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J. Clin. Invest. 1997 May 5/1/1997; 99(9): 2254-9. PMID: 9151799, PMCID: PMC508057, DOI: 10.1172/JCI119400, ISSN: 0021-9738.

Zhang T, Nanney LB, Peeler MO, Williams CS, Lamps L, Heppner KJ, DuBois RN, Beauchamp RD. Decreased transforming growth factor beta type II receptor expression in intestinal adenomas from Min/+ mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression. Cancer Res. 1997 May 5/1/1997; 57(9): 1638-43. PMID: 9134999, ISSN: 0008-5472.

Sheng H, Shao J, Hooton EB, Tsujii M, DuBois RN, Beauchamp RD. Cyclooxygenase-2 induction and transforming growth factor beta growth inhibition in rat intestinal epithelial cells. Cell Growth Differ. 1997 Apr; 8(4): 463-70. PMID: 9101092, ISSN: 1044-9523.

Zhang T, Nanney LB, Luongo C, Lamps L, Heppner KJ, DuBois RN, Beauchamp RD. Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res. 1997 Jan 1/1/1997; 57(1): 169-75. PMID: 8988060, ISSN: 0008-5472.

Sheng, G., Shao, J., Sheng, H., Hooton, E., Isakson, P., Morrow, J., Coffey, R., DuBois, R., Beauchamp, R. A Selective Cyclooxygenase 2 Inhibitor Suppresses the Growth of H-ras-Transformed Rat Intestinal Epithelial Cells. Gastroenterology. 1997; 113: 1883-91.

Sheng, H., Shao, J., Hooton, E.B., Masahiko, T., DuBois, R.N., Beauchamp, R.D. Cyclooxygenase-2 induction and transforming growth factor (TGF)-b growth inhibition in rat intestinal epithelial cells. Cell Growth and Differentiation. 1997; 8: 463-70.

Sheng, H., Shao, J., Kirkland, S.C., Isakson, P., Coffey, R.J., Morrow, J., Beauchamp, R.D., DuBois R.N. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. The Journal of Clinical Investigation. 1997; 99: 2254-9.

Zhang, T., Nanney, L.B., Luongo, C., Lamps, L., Heppner, K.J., DuBois, R.N., and Beauchamp, R.D. Concurrent overexpression of cyclin D1 and Cdk4 in intestinal adenomas from min mice and human familial adenomatous polyposis patients. Cancer Research. 1997; 57: 169-75.

Zhang, T., Nanney, L.B., Peeler, M.O., Williams, C.S., Lamps, L., Heppner, K.J., DuBois, R.N., and Beauchamp, R.D. Decreased TFG- type II receptor expression in intestinal adenomas from Min/+ Mice is associated with increased cyclin D1 and Cdk4 expression. Cancer Research. 1997; 57: 1638-43.

Chinery, R., Brockman, J.A., Peeler, M.O., Shyr, Y., Beauchamp, R.D., and Coffey, R.J. Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21Waf1/Cip1 via C/EBP. Nature Medicine. 1997; 3: 1-9.

Williams CS, Luongo C, Radhika A, Zhang T, Lamps LW, Nanney LB, Beauchamp RD, DuBois RN. Elevated cyclooxygenase-2 levels in Min mouse adenomas. Gastroenterology. 1996 Oct; 111(4): 1134-40. PMID: 8831610, PII: S0016-5085(96)70083-5, ISSN: 0016-5085.

Beauchamp RD, Sheng HM, Shao JY, Thompson EA, Ko TC. Intestinal cell cycle regulations. Interactions of cyclin D1, Cdk4, and p21Cip1. Ann. Surg. 1996 May; 223(5): 620-7; discussion 627. PMID: 8651753, PMCID: PMC1235195, ISSN: 0003-4932.

DuBois RN, Shao J, Tsujii M, Sheng H, Beauchamp RD. G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2. Cancer Res. 1996 Feb 2/15/1996; 56(4): 733-7. PMID: 8631005, ISSN: 0008-5472.

DuBois, R. N., Shao, J., Masahiko, T., Sheng, H-M., Beauchamp, R.D. G1 delay in cells overexpressing prostaglandin endoperoxide synthase-21. Cancer Research. 1996; 56: 733-7.

Williams, C.S., Luongo, C., Radhika, A., Zhang, R., Lamps, L.W., Nanney, L.B., Beauchamp, R.D., Dubois, R.N. Elevated cyclooxygenase-2 levels in min mouse adenomas. Gastroenterology. 1996; 111: 1134-40.

Barnard JA, Beauchamp RD, Russell WE, Dubois RN, Coffey RJ. Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology. 1995 Feb; 108(2): 564-80. PMID: 7835600, ISSN: 0016-5085.

Ko, T.C., Sheng, H.M.,,Reisman, D., Thompson, E.A., Beauchamp, R.D. Transforming growth factor- inhibits cyclin D1 Expression of intestinal epithelial clls. Oncongene. 1995; 10: 177-84.

Barnard, J.A., Beauchamp, R.D., Russell, W.E., DuBois, R.N., Coffey, R.J. Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology. 1995; 108: 564-80.

Parekh, D., Ishizuka, J., Townsend, C.M. Jr., Haber, B., Beauchamp, R.D., Karp, G., Kim, S.W., Rajaraman, S., Greeley, G.H. Jr., Thompson, J.C. Characterization of a human pancreatic carcinoid in vitro: morphology, amine and peptide storage and secretion. Pancreas. 1994; 9: 83-90.

Ko, T.C., Beauchamp, R.D., Townsend, C.M. Jr., Thompson, E.A., Thompson, J.C. Transforming growth factor beta inhibits rat intestinal cell growth by regulating cell cycle specific gene expression. American Journal of Surgery. 1994; 167: 14-20.

Beauchamp, R.D., Papaconstantinou, J., Henderson, A.M., Sheng, H-M., Townsend, C.M. Jr.,Thompson, J.C. Activation of hepatic proliferation-associated transcription factors by lipopolysaccharide. Surgery. 1994; 116: 367-77.

Sumi, S., Beauchamp, R.D., Townsend, C.M. Jr., Pour, P.M., Ishizuka, J., Thompson, J.C. Lovastatin inhibits pancreatic cancer growth regardless of ras mutation. Pancreas. 1994; 90: 657-61.

Guo, Y-S., Beauchamp, RD., Jin, G-F., Townsend, C.M. Jr., Thompson, J.C. Insulinlike growth factor-binding protein modulates the growth response to insulinlike growth factor 1 by human gastric cancer cells. Gastroenterology. 1993; 104: 1595-604.

Ko, T.C., Beauchamp, R.D., Townsend, C.M. Jr., Thompson, J.C. Glutamine is essential for epidermal growth factor-stimulated intestinal cell proliferation. Surgery. 1993; 114: 147-54.

Ishizuka, J., Beauchamp, R.D., Sato, K., Townsend, C.M. Jr., Thompson, J.C. Novel action of transforming growth factor  1 in functioning human pancreatic carcinoid cells. Journal of Cellular Physiology. 1993; 156: 112-8.

Polk WH, Dempsey PJ, Russell WE, Brown PI, Beauchamp RD, Barnard JA, Coffey RJ. Increased production of transforming growth factor alpha following acute gastric injury. Gastroenterology. 1992 May; 102(5): 1467-74. PMID: 1568557, PII: S0016508592001859, ISSN: 0016-5085.

Ishizuka, J., Beauchamp, R.D., Evers, B.M., Townsend, C.M. Jr., Thompson, J.C. Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells. Biochemical and Biophysical Research Communications. 1992; 185: 577-81.

Sumi, S., Beauchamp, R.D., Townsend, C.M. Jr., Uchida, T., Murakami, M., Rajaraman, S., Ishizuka, J., Thompson, J.C. Inhibition of pancreatic adenocarcinoma cell growth by lovastatin. Gastroenterology. 1992; 103: 982-9.

Beauchamp, R.D., Sheng, H-M., Ishizuka, J., Townsend, C.M. Jr., Thompson, J.C. Transforming growth factor (TGF)- stimulates hepatic jun-B and fos-B proto-oncogenes and decreases albumin mRNA. Annals of Surgery. 1992; 216: 300-8.

Chung, D.H., Evers, B.M., Beauchamp, R.D., Upp, J.R. Jr., Rajaraman, S., Townsend, C.M. Jr., Thompson, J.C. Bombesin stimulates growth of human gastrinoma. Surgery. 1992; 112: 1059-65.

Beauchamp, R.D., Sheng, H-M., Alam, T., Townsend, C.M. Jr., Papaconstantinou, J. Posttranscriptional regulation of albumin and -fetoprotein messenger RNA by transforming growth factor- 1 requires de novo RNA and protein synthesis. Molecular Endocrinology. 1992; 6: 1789-96.

Beauchamp RD, Lyons RM, Yang EY, Coffey RJ, Moses HL. Expression of and response to growth regulatory peptides by two human pancreatic carcinoma cell lines. Pancreas. 1990 Jul; 5(4): 369-80. PMID: 2199964, ISSN: 0885-3177.

Beauchamp RD, Barnard JA, McCutchen CM, Cherner JA, Coffey RJ. Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal. J. Clin. Invest. 1989 Sep; 84(3): 1017-23. PMID: 2760208, PMCID: PMC329750, DOI: 10.1172/JCI114223, ISSN: 0021-9738.

Barnard JA, Beauchamp RD, Coffey RJ, Moses HL. Regulation of intestinal epithelial cell growth by transforming growth factor type beta. Proc. Natl. Acad. Sci. U.S.A. 1989 Mar; 86(5): 1578-82. PMID: 2466294, PMCID: PMC286741, ISSN: 0027-8424.