Barbara G. Schneider, Ph.D.

Research Professor

barbara.schneider@vanderbilt.edu
Faculty Appointments
Research Professor of Medicine
Education
Ph.D., Cellular and Structural Biology, University of Texas, San Antonio, TexasM.A., Human Biology, Chemistry and Genetics, University of Texas, San Antonio, TexasB.S., Biology, Baylor University, Waco, Texas
Office Address
1030 MRB IV
2215 Garland Avenue
Nashville, TN 37232-0252
Research Keywords
gastric cancer, Helicobacter, DNA methylation, biomarkers
Publications
. Comprehensive molecular characterization of gastric adenocarcinoma. Nature [print-electronic]. 2014 Sep 9/11/2014; 513(7517): 202-9. PMID: 25079317, PMCID: PMC4170219, PII: nature13480, DOI: 10.1038/nature13480, ISSN: 1476-4687.

Kodaman N, Pazos A, Schneider BG, Piazuelo MB, Mera R, Sobota RS, Sicinschi LA, Shaffer CL, Romero-Gallo J, de Sablet T, Harder RH, Bravo LE, Peek RM, Wilson KT, Cover TL, Williams SM, Correa P. Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2014 Jan 1/28/2014; 111(4): 1455-60. PMID: 24474772, PMCID: PMC3910595, PII: 1318093111, DOI: 10.1073/pnas.1318093111, ISSN: 1091-6490.

Schneider BG, Piazuelo MB, Sicinschi LA, Mera R, Peng DF, Roa JC, Romero-Gallo J, Delgado AG, de Sablet T, Bravo LE, Wilson KT, El-Rifai W, Peek RM, Correa P. Virulence of infecting Helicobacter pylori strains and intensity of mononuclear cell infiltration are associated with levels of DNA hypermethylation in gastric mucosae. Epigenetics [print-electronic]. 2013 Nov; 8(11): 1153-61. PMID: 24128875, PMCID: PMC3927747, PII: 26072, DOI: 10.4161/epi.26072, ISSN: 1559-2308.

Arboleda RN, Schneider BG, Bravo LE, Romero-Gallo J, Peek RM, Mera RM, Yepez MC, Campo C, Correa P. Use of the noninvasive entero-test in the detection of Helicobacter pylori in children in an endemic area in Colombia. J. Pediatr. Gastroenterol. Nutr. 2013 Aug; 57(2): 192-6. PMID: 23880626, PMCID: PMC3725653, PII: 00005176-201308000-00013, DOI: 10.1097/MPG.0b013e318293e1e1, ISSN: 1536-4801.

Schneider BG, Peek RM. Gastric cancer prevention by demethylation. Cancer Prev Res (Phila). 2013 Apr; 6(4): 253-6. PMID: 23559450, PMCID: PMC3620723, PII: 6/4/253, DOI: 10.1158/1940-6207.CAPR-13-0067, ISSN: 1940-6215.

Sicinschi LA, Correa P, Bravo LE, Peek RM, Wilson KT, Loh JT, Yepez MC, Gold BD, Thompson DT, Cover TL, Schneider BG. Non-invasive genotyping of Helicobacter pylori cagA, vacA, and hopQ from asymptomatic children. Helicobacter. 2012 Apr; 17(2): 96-106. PMID: 22404439, PMCID: PMC3305281, DOI: 10.1111/j.1523-5378.2011.00919.x, ISSN: 1523-5378.

Peng DF, Hu TL, Schneider BG, Chen Z, Xu ZK, El-Rifai W. Silencing of glutathione peroxidase 3 through DNA hypermethylation is associated with lymph node metastasis in gastric carcinomas. PLoS ONE [print-electronic]. 2012; 7(10): e46214. PMID: 23071548, PMCID: PMC3468580, PII: PONE-D-12-10711, DOI: 10.1371/journal.pone.0046214, ISSN: 1932-6203.

de Sablet T, Piazuelo MB, Shaffer CL, Schneider BG, Asim M, Chaturvedi R, Bravo LE, Sicinschi LA, Delgado AG, Mera RM, Israel DA, Romero-Gallo J, Peek RM, Cover TL, Correa P, Wilson KT. Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut [print-electronic]. 2011 Sep; 60(9): 1189-95. PMID: 21357593, PMCID: PMC3133872, PII: gut.2010.234468, DOI: 10.1136/gut.2010.234468, ISSN: 1468-3288.

Soutto M, Belkhiri A, Piazuelo MB, Schneider BG, Peng D, Jiang A, Washington MK, Kokoye Y, Crowe SE, Zaika A, Correa P, Peek RM, El-Rifai W. Loss of TFF1 is associated with activation of NF-¿B-mediated inflammation and gastric neoplasia in mice and humans. J. Clin. Invest [print-electronic]. 2011 May; 121(5): 1753-67. PMID: 21490402, PMCID: PMC3083788, PII: 43922, DOI: 10.1172/JCI43922, ISSN: 1558-8238.

Zabaleta J, Camargo MC, Ritchie MD, Piazuelo MB, Sierra RA, Turner SD, Delgado A, Fontham ET, Schneider BG, Correa P, Ochoa AC. Association of haplotypes of inflammation-related genes with gastric preneoplastic lesions in African Americans and Caucasians. Int. J. Cancer. 2011 Feb 2/1/2011; 128(3): 668-75. PMID: 20473875, PMCID: PMC2964400, DOI: 10.1002/ijc.25385, ISSN: 1097-0215.

Schneider BG, Peng DF, Camargo MC, Piazuelo MB, Sicinschi LA, Mera R, Romero-Gallo J, Delgado AG, Bravo LE, Wilson KT, Peek RM, Correa P, El-Rifai W. Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer. Int. J. Cancer. 2010 Dec 12/1/2010; 127(11): 2588-97. PMID: 20178103, PMCID: PMC2916942, DOI: 10.1002/ijc.25274, ISSN: 1097-0215.

Sicinschi LA, Correa P, Peek RM, Camargo MC, Piazuelo MB, Romero-Gallo J, Hobbs SS, Krishna U, Delgado A, Mera R, Bravo LE, Schneider BG. CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions. Clin. Microbiol. Infect [print-electronic]. 2010 Apr; 16(4): 369-78. PMID: 19456839, PMCID: PMC2837774, PII: S1198-743X(14)63302-4, DOI: 10.1111/j.1469-0691.2009.02811.x, ISSN: 1469-0691.

Schneider N, Krishna U, Romero-Gallo J, Israel DA, Piazuelo MB, Camargo MC, Sicinschi LA, Schneider BG, Correa P, Peek RM. Role of Helicobacter pylori CagA molecular variations in induction of host phenotypes with carcinogenic potential. J. Infect. Dis. 2009 Apr 4/15/2009; 199(8): 1218-21. PMID: 19278338, PMCID: PMC2828761, DOI: 10.1086/597416, ISSN: 0022-1899.

Piazuelo MB, Camargo MC, Mera RM, Delgado AG, Peek RM, Correa H, Schneider BG, Sicinschi LA, Mora Y, Bravo LE, Correa P. Eosinophils and mast cells in chronic gastritis: possible implications in carcinogenesis. Hum. Pathol [print-electronic]. 2008 Sep; 39(9): 1360-9. PMID: 18614201, PMCID: PMC2561958, PII: S0046-8177(08)00058-0, DOI: 10.1016/j.humpath.2008.01.012, ISSN: 1532-8392.

O'Brien DP, Romero-Gallo J, Schneider BG, Chaturvedi R, Delgado A, Harris EJ, Krishna U, Ogden SR, Israel DA, Wilson KT, Peek RM. Regulation of the Helicobacter pylori cellular receptor decay-accelerating factor. J. Biol. Chem [print-electronic]. 2008 Aug 8/29/2008; 283(35): 23922-30. PMID: 18579524, PMCID: PMC2527108, PII: M801144200, DOI: 10.1074/jbc.M801144200, ISSN: 0021-9258.

Camargo MC, Burk RF, Bravo LE, Piazuelo MB, Hill KE, Fontham ET, Motley AK, Yepez MC, Mora Y, Schneider BG, Correa P. Plasma selenium measurements in subjects from areas with contrasting gastric cancer risks in Colombia. Arch. Med. Res [print-electronic]. 2008 May; 39(4): 443-51. PMID: 18375257, PMCID: PMC2394852, PII: S0188-4409(08)00005-2, DOI: 10.1016/j.arcmed.2007.12.004, ISSN: 0188-4409.

Sicinschi LA, Correa P, Peek RM, Camargo MC, Delgado A, Piazuelo MB, Romero-Gallo J, Bravo LE, Schneider BG. Helicobacter pylori genotyping and sequencing using paraffin-embedded biopsies from residents of colombian areas with contrasting gastric cancer risks. Helicobacter. 2008 Apr; 13(2): 135-45. PMID: 18321303, PMCID: PMC2977907, PII: HEL554, DOI: 10.1111/j.1523-5378.2008.00554.x, ISSN: 1523-5378.

Schneider BG, Camargo MC, Ryckman KK, Sicinschi LA, Piazuelo MB, Zabaleta J, Correa P, Williams SM. Cytokine polymorphisms and gastric cancer risk: an evolving view. Cancer Biol. Ther [print-electronic]. 2008 Feb; 7(2): 157-62. PMID: 18059184, PII: 5270, ISSN: 1555-8576.

Zabaleta J, Schneider BG, Ryckman K, Hooper PF, Camargo MC, Piazuelo MB, Sierra RA, Fontham ET, Correa P, Williams SM, Ochoa AC. Ethnic differences in cytokine gene polymorphisms: potential implications for cancer development. Cancer Immunol. Immunother [print-electronic]. 2008 Jan; 57(1): 107-14. PMID: 17618436, DOI: 10.1007/s00262-007-0358-4, ISSN: 0340-7004.

Schneider BG, Sahni D, Torres JC, Dushku N, Reid TW. MLH1 and MSH2 expression in pterygia. Cornea. 2007 May; 26(4): 468-72. PMID: 17457197, PII: 00003226-200705000-00015, DOI: 10.1097/ICO.0b013e3180316c76, ISSN: 0277-3740.

Camargo MC, Mera R, Correa P, Peek RM, Piazuelo MB, Sicinschi L, Schneider BG, Zabaleta J, Fontham ET, Goodman KJ, Ryckman KK. IL1B polymorphisms and gastric cancer risk [letter]. Cancer Epidemiol. Biomarkers Prev. 2007 Mar; 16(3): 635; author reply 635-6. PMID: 17372270, PII: 16/3/635, DOI: 10.1158/1055-9965.EPI-06-0925, ISSN: 1055-9965.

Camargo MC, Mera R, Correa P, Peek RM, Fontham ET, Goodman KJ, Piazuelo MB, Sicinschi L, Zabaleta J, Schneider BG. Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis. Cancer Epidemiol. Biomarkers Prev. 2006 Sep; 15(9): 1674-87. PMID: 16985030, PII: 15/9/1674, DOI: 10.1158/1055-9965.EPI-06-0189, ISSN: 1055-9965.

Peek RM, Schneider BG, Correa P. Coming unglued. Clin. Cancer Res. 2006 May 5/15/2006; 12(10): 2951-4. PMID: 16707587, PII: 12/10/2951, DOI: 10.1158/1078-0432.CCR-06-0460, ISSN: 1078-0432.

Sicinschi LA, Lopez-Carrillo L, Camargo MC, Correa P, Sierra RA, Henry RR, Chen J, Zabaleta J, Piazuelo MB, Schneider BG. Gastric cancer risk in a Mexican population: role of Helicobacter pylori CagA positive infection and polymorphisms in interleukin-1 and -10 genes. Int. J. Cancer. 2006 Feb 2/1/2006; 118(3): 649-57. PMID: 16114018, DOI: 10.1002/ijc.21364, ISSN: 0020-7136.

Zabaleta J, Camargo MC, Piazuelo MB, Fontham E, Schneider BG, Sicinschi LA, Ferrante W, Balart L, Correa P, Ochoa AC. Association of interleukin-1beta gene polymorphisms with precancerous gastric lesions in African Americans and Caucasians. Am. J. Gastroenterol. 2006 Jan; 101(1): 163-71. PMID: 16405550, PII: AJG387, DOI: 10.1111/j.1572-0241.2006.00387.x, ISSN: 0002-9270.

Schneider BG, John-Aryankalayil M, Rowsey JJ, Dushku N, Reid TW. Accumulation of p53 protein in pterygia is not accompanied by TP53 gene mutation. Exp. Eye Res [print-electronic]. 2006 Jan; 82(1): 91-8. PMID: 16005868, PII: S0014-4835(05)00157-0, DOI: 10.1016/j.exer.2005.05.006, ISSN: 0014-4835.

Correa P, Schneider BG. Etiology of gastric cancer: what is new?. Cancer Epidemiol. Biomarkers Prev. 2005 Aug; 14(8): 1865-8. PMID: 16103427, PII: 14/8/1865, DOI: 10.1158/1055-9965.EPI-05-0029, ISSN: 1055-9965.