Talat Alp Ikizler, M.D.



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Faculty Appointments
Professor of Medicine Catherine McLaughlin Hakim Chair in Vascular Biology
M.D., Medicine, Istanbul Universitesi, Istanbul, Turkey
Office Address
S-3223 MCN
TN 2372
Research Description
Clinical Research Keywords
Nephrology, Nutrition, Metabolism, Acute Renal Failure, Hemodialysis, Vascular Access
Deger SM, Sundell MB, Siew ED, Egbert P, Ellis CD, Sha F, Ikizler TA, Hung AM. Insulin resistance and protein metabolism in chronic hemodialysis patients. J Ren Nutr [print-electronic]. 2013 May; 23(3): e59-66. PMID: 23194840, PMCID: PMC3852904, PII: S1051-2276(12)00198-7, DOI: 10.1053/j.jrn.2012.08.013, ISSN: 1532-8503.

Hung AM, Sundell MB, Plotnikova NE, Bian A, Shintani A, Ellis CD, Siew ED, Ikizler TA. A pilot study of active vitamin D administration and insulin resistance in African American patients undergoing chronic hemodialysis. J Ren Nutr [print-electronic]. 2013 May; 23(3): 185-93. PMID: 22959781, PMCID: PMC3519966, PII: S1051-2276(12)00143-4, DOI: 10.1053/j.jrn.2012.06.005, ISSN: 1532-8503.

Buchowski MS, Simmons SF, Whitaker LE, Powers J, Beuscher L, Choi L, Ikizler TA, Chen K, Shnelle JF. Fatigability as a function of physical activity energy expenditure in older adults. Age (Dordr) [print-electronic]. 2013 Feb; 35(1): 179-87. PMID: 22113348, PMCID: PMC3543733, DOI: 10.1007/s11357-011-9338-x, ISSN: 1574-4647.

Siew ED, Peterson JF, Eden SK, Moons KG, Ikizler TA, Matheny ME. Use of multiple imputation method to improve estimation of missing baseline serum creatinine in acute kidney injury research. Clin J Am Soc Nephrol [print-electronic]. 2013 Jan; 8(1): 10-8. PMID: 23037980, PMCID: PMC3531649, PII: CJN.00200112, DOI: 10.2215/CJN.00200112, ISSN: 1555-905X.

Yamamoto S, Yancey PG, Ikizler TA, Jerome WG, Kaseda R, Cox B, Bian A, Shintani A, Fogo AB, Linton MF, Fazio S, Kon V. Dysfunctional high-density lipoprotein in patients on chronic hemodialysis. J. Am. Coll. Cardiol [print-electronic]. 2012 Dec 12/11/2012; 60(23): 2372-9. PMID: 23141484, PII: S0735-1097(12)04651-7, DOI: 10.1016/j.jacc.2012.09.013, ISSN: 1558-3597.

King-Morris K, Ikizler TA. Insulin resistance in patients undergoing peritoneal dialysis: can we improve it? : editorial to: "the effect of HM-CoA reductase inhibitor on insulin resistance in patients undergoing peritoneal dialysis" by Fa Mee Doh et al [editorial]. Cardiovasc Drugs Ther. 2012 Dec; 26(6): 441-3. PMID: 23161070, PMCID: PMC4118763, DOI: 10.1007/s10557-012-6423-z, ISSN: 1573-7241.

Schnelle JF, Buchowski MS, Ikizler TA, Durkin DW, Beuscher L, Simmons SF. Evaluation of two fatigability severity measures in elderly adults. J Am Geriatr Soc [print-electronic]. 2012 Aug; 60(8): 1527-33. PMID: 22860899, PMCID: PMC3419324, DOI: 10.1111/j.1532-5415.2012.04062.x, ISSN: 1532-5415.

Billings FT, Pretorius M, Schildcrout JS, Mercaldo ND, Byrne JG, Ikizler TA, Brown NJ. Obesity and oxidative stress predict AKI after cardiac surgery. J. Am. Soc. Nephrol [print-electronic]. 2012 Jul; 23(7): 1221-8. PMID: 22626819, PMCID: PMC3380645, PII: ASN.2011090940, DOI: 10.1681/ASN.2011090940, ISSN: 1533-3450.

Maripuri S, Arbogast P, Ikizler TA, Cavanaugh KL. Rural and micropolitan residence and mortality in patients on dialysis. Clin J Am Soc Nephrol [print-electronic]. 2012 Jul; 7(7): 1121-9. PMID: 22516293, PMCID: PMC3386672, PII: CJN.10831011, DOI: 10.2215/CJN.10831011, ISSN: 1555-905X.

Siew ED, Ikizler TA, Matheny ME, Shi Y, Schildcrout JS, Danciu I, Dwyer JP, Srichai M, Hung AM, Smith JP, Peterson JF. Estimating baseline kidney function in hospitalized patients with impaired kidney function. Clin J Am Soc Nephrol [print-electronic]. 2012 May; 7(5): 712-9. PMID: 22422536, PMCID: PMC3338282, PII: CJN.10821011, DOI: 10.2215/CJN.10821011, ISSN: 1555-905X.

Hung AM, Roumie CL, Greevy RA, Liu X, Grijalva CG, Murff HJ, Ikizler TA, Griffin MR. Comparative effectiveness of incident oral antidiabetic drugs on kidney function. Kidney Int [print-electronic]. 2012 Apr; 81(7): 698-706. PMID: 22258320, PMCID: PMC3306005, PII: ki2011444, DOI: 10.1038/ki.2011.444, ISSN: 1523-1755.

Siew ED, Peterson JF, Eden SK, Hung AM, Speroff T, Ikizler TA, Matheny ME. Outpatient nephrology referral rates after acute kidney injury. J. Am. Soc. Nephrol [print-electronic]. 2012 Feb; 23(2): 305-12. PMID: 22158435, PMCID: PMC3269178, PII: ASN.2011030315, DOI: 10.1681/ASN.2011030315, ISSN: 1533-3450.

Gamboa JL, Pretorius M, Todd-Tzanetos DR, Luther JM, Yu C, Ikizler TA, Brown NJ. Comparative effects of angiotensin-converting enzyme inhibition and angiotensin-receptor blockade on inflammation during hemodialysis. J. Am. Soc. Nephrol [print-electronic]. 2012 Feb; 23(2): 334-42. PMID: 22158433, PMCID: PMC3269170, PII: ASN.2011030287, DOI: 10.1681/ASN.2011030287, ISSN: 1533-3450.

Lipworth L, Mumma MT, Cavanaugh KL, Edwards TL, Ikizler TA, Tarone RE, McLaughlin JK, Blot WJ. Incidence and predictors of end stage renal disease among low-income blacks and whites. PLoS ONE [print-electronic]. 2012; 7(10): e48407. PMID: 23110237, PMCID: PMC3480508, PII: PONE-D-12-23038, DOI: 10.1371/journal.pone.0048407, ISSN: 1932-6203.

Birdwell KA, Ikizler MR, Wang L, Byrne DW, Sannella EC, Wright PF, Ikizler TA. Seasonal maintenance of influenza vaccine-induced antibody response in kidney transplant recipients. Am. J. Nephrol [print-electronic]. 2012; 36(3): 201-7. PMID: 22906930, PMCID: PMC3482977, PII: 000341653, DOI: 10.1159/000341653, ISSN: 1421-9670.

Birdwell KA, Grady B, Choi L, Xu H, Bian A, Denny JC, Jiang M, Vranic G, Basford M, Cowan JD, Richardson DM, Robinson MP, Ikizler TA, Ritchie MD, Stein CM, Haas DW. The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients. Pharmacogenet. Genomics. 2012 Jan; 22(1): 32-42. PMID: 22108237, PMCID: PMC3237759, DOI: 10.1097/FPC.0b013e32834e1641, ISSN: 1744-6880.

Wright Nunes JA, Wallston KA, Eden SK, Shintani AK, Ikizler TA, Cavanaugh KL. Associations among perceived and objective disease knowledge and satisfaction with physician communication in patients with chronic kidney disease. Kidney Int [print-electronic]. 2011 Dec; 80(12): 1344-51. PMID: 21832984, PMCID: PMC3712792, PII: ki2011240, DOI: 10.1038/ki.2011.240, ISSN: 1523-1755.

Ikizler TA. Common nutritional misconceptions in dialysis patients. Semin Dial. 2011 Sep; 24(5): 510-2. PMID: 21999739, DOI: 10.1111/j.1525-139X.2011.00988.x, ISSN: 1525-139X.

Maripuri S, Penson DF, Ikizler TA, Cavanaugh KL. Outpatient versus inpatient observation after percutaneous native kidney biopsy: a cost minimization study. Am. J. Nephrol [print-electronic]. 2011; 34(1): 64-70. PMID: 21677428, PMCID: PMC3123742, PII: 000328901, DOI: 10.1159/000328901, ISSN: 1421-9670.

Hung AM, Ikizler TA, Griffin MR, Glenn K, Greevy RA, Grijalva CG, Siew ED, Crawford DC. CRP polymorphisms and chronic kidney disease in the third national health and nutrition examination survey. BMC Med. Genet. 2011; 12: 65. PMID: 21569369, PMCID: PMC3119179, PII: 1471-2350-12-65, DOI: 10.1186/1471-2350-12-65, ISSN: 1471-2350.

Birdwell KA, Ikizler MR, Sannella EC, Wang L, Byrne DW, Ikizler TA, Wright PF. Decreased antibody response to influenza vaccination in kidney transplant recipients: a prospective cohort study. Am. J. Kidney Dis [print-electronic]. 2009 Jul; 54(1): 112-21. PMID: 19185404, PMCID: PMC3772511, PII: S0272-6386(08)01608-9, DOI: 10.1053/j.ajkd.2008.09.023, ISSN: 1523-6838.

Brunelli SM, Thadhani R, Ikizler TA, Feldman HI. Thiazolidinedione use is associated with better survival in hemodialysis patients with non-insulin dependent diabetes. Kidney Int [print-electronic]. 2009 May; 75(9): 961-8. PMID: 19190679, PMCID: PMC2864092, PII: ki20094, DOI: 10.1038/ki.2009.4, ISSN: 1523-1755.

Ikizler TA. Dietary protein restriction in CKD: the debate continues [editorial]. Am. J. Kidney Dis. 2009 Feb; 53(2): 189-91. PMID: 19166797, PII: S0272-6386(08)01749-6, DOI: 10.1053/j.ajkd.2008.12.014, ISSN: 1523-6838.

Ikizler TA. Nutrition support for the chronically wasted or acutely catabolic chronic kidney disease patient. Semin. Nephrol. 2009 Jan; 29(1): 75-84. PMID: 19121477, PMCID: PMC3788638, PII: S0270-9295(08)00173-3, DOI: 10.1016/j.semnephrol.2008.10.011, ISSN: 0270-9295.

Kopple JD, Cheung AK, Christiansen JS, Djurhuus CB, El Nahas M, Feldt-Rasmussen B, Lange M, Mitch WE, Wanner C, Wiedemann J, Ikizler TA. OPPORTUNITY: a randomized clinical trial of growth hormone on outcome in hemodialysis patients. Clin J Am Soc Nephrol. 2008 Nov; 3(6): 1741-51. PMID: 18945992, PMCID: PMC2572295, PII: CJN.02760608, DOI: 10.2215/CJN.02760608, ISSN: 1555-905X.

Mehrotra R, Martin KJ, Fishbane S, Sprague SM, Zeig S, Anger M, . Higher strength lanthanum carbonate provides serum phosphorus control with a low tablet burden and is preferred by patients and physicians: a multicenter study. Clin J Am Soc Nephrol [print-electronic]. 2008 Sep; 3(5): 1437-45. PMID: 18579668, PMCID: PMC2518797, PII: CJN.04741107, DOI: 10.2215/CJN.04741107, ISSN: 1555-905X.

Hung AM, Ikizler TA. Hemodialysis central venous catheters as a source of inflammation and its implications [editorial]. Semin Dial [print-electronic]. 2008 Sep; 21(5): 401-4. PMID: 18573135, PII: SDI444, DOI: 10.1111/j.1525-139X.2008.00444.x, ISSN: 1525-139X.

Crowley ST, Chertow GM, Vitale J, O'Connor T, Zhang J, Schein RM, Choudhury D, Finkel K, Vijayan A, Paganini E, Palevsky PM, . Lessons for successful study enrollment from the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study. Clin J Am Soc Nephrol [print-electronic]. 2008 Jul; 3(4): 955-61. PMID: 18385390, PMCID: PMC2440269, PII: CJN.05621207, DOI: 10.2215/CJN.05621207, ISSN: 1555-905X.

Ikizler TA. Resolved: being fat is good for dialysis patients: the Godzilla effect: pro. J. Am. Soc. Nephrol [print-electronic]. 2008 Jun; 19(6): 1059-62. PMID: 18256355, PII: ASN.2007090983, DOI: 10.1681/ASN.2007090983, ISSN: 1533-3450.

Dember LM, Beck GJ, Allon M, Delmez JA, Dixon BS, Greenberg A, Himmelfarb J, Vazquez MA, Gassman JJ, Greene T, Radeva MK, Braden GL, Ikizler TA, Rocco MV, Davidson IJ, Kaufman JS, Meyers CM, Kusek JW, Feldman HI, . Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial. JAMA. 2008 May 5/14/2008; 299(18): 2164-71. PMID: 18477783, PII: 299/18/2164, DOI: 10.1001/jama.299.18.2164, ISSN: 1538-3598.

Majchrzak KM, Pupim LB, Flakoll PJ, Ikizler TA. Resistance exercise augments the acute anabolic effects of intradialytic oral nutritional supplementation. Nephrol. Dial. Transplant [print-electronic]. 2008 Apr; 23(4): 1362-9. PMID: 18065829, PII: gfm773, DOI: 10.1093/ndt/gfm773, ISSN: 1460-2385.

Hung A, Pupim L, Yu C, Shintani A, Siew E, Ayus C, Hakim RM, Ikizler TA. Determinants of C-reactive protein in chronic hemodialysis patients: relevance of dialysis catheter utilization. Hemodial Int. 2008 Apr; 12(2): 236-43. PMID: 18394058, PII: HDI260, DOI: 10.1111/j.1542-4758.2008.00260.x, ISSN: 1492-7535.

Ikizler TA. Nutrition, inflammation and chronic kidney disease. Curr. Opin. Nephrol. Hypertens. 2008 Mar; 17(2): 162-7. PMID: 18277149, PII: 00041552-200803000-00008, DOI: 10.1097/MNH.0b013e3282f5dbce, ISSN: 1062-4821.

Ramos LF, Shintani A, Ikizler TA, Himmelfarb J. Oxidative stress and inflammation are associated with adiposity in moderate to severe CKD. J. Am. Soc. Nephrol [print-electronic]. 2008 Mar; 19(3): 593-9. PMID: 18256365, PMCID: PMC2391046, PII: ASN.2007030355, DOI: 10.1681/ASN.2007030355, ISSN: 1533-3450.

Fouque D, Kalantar-Zadeh K, Kopple J, Cano N, Chauveau P, Cuppari L, Franch H, Guarnieri G, Ikizler TA, Kaysen G, Lindholm B, Massy Z, Mitch W, Pineda E, Stenvinkel P, Treviño-Becerra A, Wanner C. A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int [print-electronic]. 2008 Feb; 73(4): 391-8. PMID: 18094682, PII: 5002585, DOI: 10.1038/sj.ki.5002585, ISSN: 1523-1755.

Ikizler TA. Parenteral nutrition offers no benefit over oral supplementation in malnourished hemodialysis patients. Nat Clin Pract Nephrol [print-electronic]. 2008 Feb; 4(2): 76-7. PMID: 17998928, PII: ncpneph0675, DOI: 10.1038/ncpneph0675, ISSN: 1745-8331.

Caglar K, Yilmaz MI, Saglam M, Cakir E, Kilic S, Sonmez A, Eyileten T, Yenicesu M, Oguz Y, Tasar M, Vural A, Ikizler TA, Stenvinkel P, Lindholm B. Serum fetuin-a concentration and endothelial dysfunction in chronic kidney disease. Nephron Clin Pract [print-electronic]. 2008; 108(3): c233-40. PMID: 18334823, PII: 000120209, DOI: 10.1159/000120209, ISSN: 1660-2110.

Siew ED, Ikizler TA. Determinants of insulin resistance and its effects on protein metabolism in patients with advanced chronic kidney disease. Contrib Nephrol. 2008; 161: 138-44. PMID: 18451670, PII: 130659, DOI: 10.1159/000130659, ISSN: 0302-5144.

Trirogoff ML, Shintani A, Himmelfarb J, Ikizler TA. Body mass index and fat mass are the primary correlates of insulin resistance in nondiabetic stage 3-4 chronic kidney disease patients. Am. J. Clin. Nutr. 2007 Dec; 86(6): 1642-8. PMID: 18065581, PII: 86/6/1642, ISSN: 0002-9165.

Lacson E, Ikizler TA, Lazarus JM, Teng M, Hakim RM. Potential impact of nutritional intervention on end-stage renal disease hospitalization, death, and treatment costs. J Ren Nutr. 2007 Nov; 17(6): 363-71. PMID: 17971308, PII: S1051-2276(07)00177-X, DOI: 10.1053/j.jrn.2007.08.009, ISSN: 1532-8503.

Wingard RL, Pupim LB, Krishnan M, Shintani A, Ikizler TA, Hakim RM. Early intervention improves mortality and hospitalization rates in incident hemodialysis patients: RightStart program. Clin J Am Soc Nephrol [print-electronic]. 2007 Nov; 2(6): 1170-5. PMID: 17942761, PII: CJN.04261206, DOI: 10.2215/CJN.04261206, ISSN: 1555-905X.

Lacson E, Lazarus JM, Himmelfarb J, Ikizler TA, Hakim RM. Balancing Fistula First with Catheters Last. Am. J. Kidney Dis. 2007 Sep; 50(3): 379-95. PMID: 17720517, PII: S0272-6386(07)00926-2, DOI: 10.1053/j.ajkd.2007.06.006, ISSN: 1523-6838.

Himmelfarb J, Phinney S, Ikizler TA, Kane J, McMonagle E, Miller G. Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis patients. J Ren Nutr. 2007 Sep; 17(5): 296-304. PMID: 17720098, PII: S1051-2276(07)00112-4, DOI: 10.1053/j.jrn.2007.05.011, ISSN: 1532-8503.

Majchrzak KM, Pupim LB, Sundell M, Ikizler TA. Body composition and physical activity in end-stage renal disease. J Ren Nutr. 2007 May; 17(3): 196-204. PMID: 17462552, PMCID: PMC2746570, PII: S1051-2276(07)00002-7, DOI: 10.1053/j.jrn.2007.01.003, ISSN: 1532-8503.

Himmelfarb J, Ikizler TA. Acute kidney injury: changing lexicography, definitions, and epidemiology. Kidney Int [print-electronic]. 2007 May; 71(10): 971-6. PMID: 17396117, PII: 5002224, DOI: 10.1038/sj.ki.5002224, ISSN: 0085-2538.

Pupim LB, Flakoll PJ, Ikizler TA. Exercise improves albumin fractional synthetic rate in chronic hemodialysis patients. Eur J Clin Nutr [print-electronic]. 2007 May; 61(5): 686-9. PMID: 17180156, PII: 1602578, DOI: 10.1038/sj.ejcn.1602578, ISSN: 0954-3007.

Ikizler TA. Effects of glucose homeostasis on protein metabolism in patients with advanced chronic kidney disease. J Ren Nutr. 2007 Jan; 17(1): 13-6. PMID: 17198926, PII: S1051-2276(06)00230-5, DOI: 10.1053/j.jrn.2006.10.004, ISSN: 1532-8503.

Siew ED, Pupim LB, Majchrzak KM, Shintani A, Flakoll PJ, Ikizler TA. Insulin resistance is associated with skeletal muscle protein breakdown in non-diabetic chronic hemodialysis patients. Kidney Int [print-electronic]. 2007 Jan; 71(2): 146-52. PMID: 17063174, PII: 5001984, DOI: 10.1038/sj.ki.5001984, ISSN: 0085-2538.

Ikizler TA. Protein and energy intake in advanced chronic kidney disease: how much is too much? [editorial]. Semin Dial. 2007 Jan; 20(1): 5-11. PMID: 17244111, PII: SDI231, DOI: 10.1111/j.1525-139X.2007.00231.x, ISSN: 0894-0959.

Ikizler TA, Himmelfarb J. Trials and trade-offs in haemodialysis vascular access monitoring [editorial]. Nephrol. Dial. Transplant [print-electronic]. 2006 Dec; 21(12): 3362-3. PMID: 17005532, PII: gfl562, DOI: 10.1093/ndt/gfl562, ISSN: 0931-0509.

Pupim LB, Majchrzak KM, Flakoll PJ, Ikizler TA. Intradialytic oral nutrition improves protein homeostasis in chronic hemodialysis patients with deranged nutritional status. J. Am. Soc. Nephrol [print-electronic]. 2006 Nov; 17(11): 3149-57. PMID: 17021267, PII: ASN.2006040413, DOI: 10.1681/ASN.2006040413, ISSN: 1046-6673.

Cho KC, Himmelfarb J, Paganini E, Ikizler TA, Soroko SH, Mehta RL, Chertow GM. Survival by dialysis modality in critically ill patients with acute kidney injury. J. Am. Soc. Nephrol [print-electronic]. 2006 Nov; 17(11): 3132-8. PMID: 17021268, PII: ASN.2006030268, DOI: 10.1681/ASN.2006030268, ISSN: 1046-6673.

Liu KD, Himmelfarb J, Paganini E, Ikizler TA, Soroko SH, Mehta RL, Chertow GM. Timing of initiation of dialysis in critically ill patients with acute kidney injury. Clin J Am Soc Nephrol [print-electronic]. 2006 Sep; 1(5): 915-9. PMID: 17699307, PII: CJN.01430406, DOI: 10.2215/CJN.01430406, ISSN: 1555-905X.

Chertow GM, Soroko SH, Paganini EP, Cho KC, Himmelfarb J, Ikizler TA, Mehta RL. Mortality after acute renal failure: models for prognostic stratification and risk adjustment. Kidney Int [print-electronic]. 2006 Sep; 70(6): 1120-6. PMID: 16850028, PII: 5001579, DOI: 10.1038/sj.ki.5001579, ISSN: 0085-2538.

Ikizler TA, Himmelfarb J. Muscle wasting in kidney disease: Let's get physical [editorial]. J. Am. Soc. Nephrol [print-electronic]. 2006 Aug; 17(8): 2097-8. PMID: 16837638, PII: ASN.2006060629, DOI: 10.1681/ASN.2006060629, ISSN: 1046-6673.

Pupim LB, Cuppari L, Ikizler TA. Nutrition and metabolism in kidney disease. Semin. Nephrol. 2006 Mar; 26(2): 134-57. PMID: 16530606, PII: S0270-9295(05)00187-7, DOI: 10.1016/j.semnephrol.2005.09.010, ISSN: 0270-9295.

Yilmaz MI, Korkmaz A, Kaya A, Sonmez A, Caglar K, Topal T, Eyileten T, Yenicesu M, Acikel C, Oter S, Yaman H, Aktug H, Oguz Y, Vural A, Ikizler TA. Hyperbaric oxygen treatment augments the efficacy of a losartan regime in an experimental nephrotic syndrome model. Nephron Exp. Nephrol [print-electronic]. 2006; 104(1): e15-22. PMID: 16699289, PII: 93260, DOI: 10.1159/000093260, ISSN: 1660-2129.

Pupim LB, Flakoll PJ, Yu C, Ikizler TA. Recombinant human growth hormone improves muscle amino acid uptake and whole-body protein metabolism in chronic hemodialysis patients. Am. J. Clin. Nutr. 2005 Dec; 82(6): 1235-43. PMID: 16332656, PII: 82/6/1235, ISSN: 0002-9165.

Ikizler TA, Schulman G. Hemodialysis: techniques and prescription. Am. J. Kidney Dis. 2005 Nov; 46(5): 976-81. PMID: 16253743, PII: S0272-6386(05)01048-6, DOI: 10.1053/j.ajkd.2005.07.037, ISSN: 1523-6838.

Pupim LB, Heimbürger O, Qureshi AR, Ikizler TA, Stenvinkel P. Accelerated lean body mass loss in incident chronic dialysis patients with diabetes mellitus. Kidney Int. 2005 Nov; 68(5): 2368-74. PMID: 16221242, PII: KID699, DOI: 10.1111/j.1523-1755.2005.00699.x, ISSN: 0085-2538.

Pupim LB, Flakoll PJ, Majchrzak KM, Aftab Guy DL, Stenvinkel P, Ikizler TA. Increased muscle protein breakdown in chronic hemodialysis patients with type 2 diabetes mellitus. Kidney Int. 2005 Oct; 68(4): 1857-65. PMID: 16164664, PII: KID605, DOI: 10.1111/j.1523-1755.2005.00605.x, ISSN: 0085-2538.

Basi S, Pupim LB, Simmons EM, Sezer MT, Shyr Y, Freedman S, Chertow GM, Mehta RL, Paganini E, Himmelfarb J, Ikizler TA. Insulin resistance in critically ill patients with acute renal failure. Am. J. Physiol. Renal Physiol [print-electronic]. 2005 Aug; 289(2): F259-64. PMID: 15840772, PII: 00002.2005, DOI: 10.1152/ajprenal.00002.2005, ISSN: 1931-857X.

Yenicesu M, Yilmaz MI, Caglar K, Sonmez A, Eyileten T, Kir T, Acikel C, Bingol N, Oguz Y, Ikizler TA, Vural A. Adiponectin level is reduced and inversely correlated with the degree of proteinuria in type 2 diabetic patients. Clin. Nephrol. 2005 Jul; 64(1): 12-9. PMID: 16047640, ISSN: 0301-0430.

Simmons EM, Langone A, Sezer MT, Vella JP, Recupero P, Morrow JD, Ikizler TA, Himmelfarb J. Effect of renal transplantation on biomarkers of inflammation and oxidative stress in end-stage renal disease patients. Transplantation. 2005 Apr 4/27/2005; 79(8): 914-9. PMID: 15849543, PII: 00007890-200504270-00008, ISSN: 0041-1337.

Majchrzak KM, Pupim LB, Chen K, Martin CJ, Gaffney S, Greene JH, Ikizler TA. Physical activity patterns in chronic hemodialysis patients: comparison of dialysis and nondialysis days. J Ren Nutr. 2005 Apr; 15(2): 217-24. PMID: 15827895, PII: S1051227604001372, ISSN: 1532-8503.

Lim VS, Ikizler TA, Raj DS, Flanigan MJ. Does hemodialysis increase protein breakdown? Dissociation between whole-body amino acid turnover and regional muscle kinetics. J. Am. Soc. Nephrol [print-electronic]. 2005 Apr; 16(4): 862-8. PMID: 15716333, PII: ASN.2004080624, DOI: 10.1681/ASN.2004080624, ISSN: 1046-6673.

Ikizler TA. Effects of hemodialysis on protein metabolism. J Ren Nutr. 2005 Jan; 15(1): 39-43. PMID: 15648005, PII: S1051227604001761, ISSN: 1532-8503.

Himmelfarb J, Le P, Klenzak J, Freedman S, McMenamin ME, Ikizler TA, . Impaired monocyte cytokine production in critically ill patients with acute renal failure. Kidney Int. 2004 Dec; 66(6): 2354-60. PMID: 15569326, PII: KID66023, DOI: 10.1111/j.1523-1755.2004.66023.x, ISSN: 0085-2538.

Ikizler TA. Protein and energy: recommended intake and nutrient supplementation in chronic dialysis patients. Semin Dial. 2004 Nov; 17(6): 471-8. PMID: 15660578, PII: SDI17608, DOI: 10.1111/j.0894-0959.2004.17608.x, ISSN: 0894-0959.

Pupim LB, Caglar K, Hakim RM, Shyr Y, Ikizler TA. Uremic malnutrition is a predictor of death independent of inflammatory status. Kidney Int. 2004 Nov; 66(5): 2054-60. PMID: 15496179, PII: KID978, DOI: 10.1111/j.1523-1755.2004.00978.x, ISSN: 0085-2538.

Mehta RL, Pascual MT, Soroko S, Savage BR, Himmelfarb J, Ikizler TA, Paganini EP, Chertow GM, . Spectrum of acute renal failure in the intensive care unit: the PICARD experience. Kidney Int. 2004 Oct; 66(4): 1613-21. PMID: 15458458, PII: KID927, DOI: 10.1111/j.1523-1755.2004.00927.x, ISSN: 0085-2538.

Himmelfarb J, McMonagle E, Freedman S, Klenzak J, McMenamin E, Le P, Pupim LB, Ikizler TA, The PICARD Group. Oxidative stress is increased in critically ill patients with acute renal failure. J. Am. Soc. Nephrol. 2004 Sep; 15(9): 2449-56. PMID: 15339994, PII: 15/9/2449, DOI: 10.1097/01.ASN.0000138232.68452.3B, ISSN: 1046-6673.

Pupim LB, Flakoll PJ, Ikizler TA. Nutritional supplementation acutely increases albumin fractional synthetic rate in chronic hemodialysis patients. J. Am. Soc. Nephrol. 2004 Jul; 15(7): 1920-6. PMID: 15213282, ISSN: 1046-6673.

Pupim LB, Himmelfarb J, McMonagle E, Shyr Y, Ikizler TA. Influence of initiation of maintenance hemodialysis on biomarkers of inflammation and oxidative stress. Kidney Int. 2004 Jun; 65(6): 2371-9. PMID: 15149350, PII: KID656, DOI: 10.1111/j.1523-1755.2004.00656.x, ISSN: 0085-2538.

Pupim LB, Flakoll PJ, Levenhagen DK, Ikizler TA. Exercise augments the acute anabolic effects of intradialytic parenteral nutrition in chronic hemodialysis patients. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Apr; 286(4): E589-97. PMID: 14678952, PII: 00384.2003, DOI: 10.1152/ajpendo.00384.2003, ISSN: 0193-1849.

Ikizler TA. Role of nutrition for cardiovascular risk reduction in chronic kidney disease patients. Adv Chronic Kidney Dis. 2004 Apr; 11(2): 162-71. PMID: 15216487, PII: S1548559504000096, ISSN: 1548-5595.

Simmons EM, Himmelfarb J, Sezer MT, Chertow GM, Mehta RL, Paganini EP, Soroko S, Freedman S, Becker K, Spratt D, Shyr Y, Ikizler TA, . Plasma cytokine levels predict mortality in patients with acute renal failure. Kidney Int. 2004 Apr; 65(4): 1357-65. PMID: 15086475, DOI: 10.1111/j.1523-1755.2004.00512.x, ISSN: 0085-2538.

Eustace JA, Astor B, Muntner PM, Ikizler TA, Coresh J. Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease. Kidney Int. 2004 Mar; 65(3): 1031-40. PMID: 14871424, DOI: 10.1111/j.1523-1755.2004.00481.x, ISSN: 0085-2538.

Oberg BP, McMenamin E, Lucas FL, McMonagle E, Morrow J, Ikizler TA, Himmelfarb J. Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease. Kidney Int. 2004 Mar; 65(3): 1009-16. PMID: 14871421, DOI: 10.1111/j.1523-1755.2004.00465.x, ISSN: 0085-2538.

Ikizler TA, Sezer MT, Flakoll PJ, Hariachar S, Kanagasundaram NS, Gritter N, Knights S, Shyr Y, Paganini E, Hakim RM, Himmelfarb J, . Urea space and total body water measurements by stable isotopes in patients with acute renal failure. Kidney Int. 2004 Feb; 65(2): 725-32. PMID: 14717948, DOI: 10.1111/j.1523-1755.2004.00439.x, ISSN: 0085-2538.

Flakoll PJ, Kent P, Neyra R, Levenhagen D, Chen KY, Ikizler TA. Bioelectrical impedance vs air displacement plethysmography and dual-energy X-ray absorptiometry to determine body composition in patients with end-stage renal disease. JPEN J Parenter Enteral Nutr. 2004 Jan; 28(1): 13-21. PMID: 14763788, ISSN: 0148-6071.

Pupim LB, Ikizler TA. Assessment and monitoring of uremic malnutrition. J Ren Nutr. 2004 Jan; 14(1): 6-19. PMID: 14740325, PII: S1051227603001808, ISSN: 1532-8503.

Pupim LB, Flakoll PJ, Ikizler TA. Protein homeostasis in chronic hemodialysis patients. Curr Opin Clin Nutr Metab Care. 2004 Jan; 7(1): 89-95. PMID: 15090908, PII: 00075197-200401000-00014, ISSN: 1363-1950.

Kalantar-Zadeh K, Ikizler TA, Block G, Avram MM, Kopple JD. Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences. Am. J. Kidney Dis. 2003 Nov; 42(5): 864-81. PMID: 14582032, PII: S0272638603010059, ISSN: 1523-6838.

Pupim LB, Evanson JA, Hakim RM, Ikizler TA. The extent of uremic malnutrition at the time of initiation of maintenance hemodialysis is associated with subsequent hospitalization. J Ren Nutr. 2003 Oct; 13(4): 259-66. PMID: 14566762, PII: S1051227603001043, ISSN: 1532-8503.

Chertow GM, Pascual MT, Soroko S, Savage BR, Himmelfarb J, Ikizler TA, Paganini EP, Mehta RL, . Reasons for non-enrollment in a cohort study of ARF: the Program to Improve Care in Acute Renal Disease (PICARD) experience and implications for a clinical trials network. Am. J. Kidney Dis. 2003 Sep; 42(3): 507-12. PMID: 12955678, PII: S0272638603007455, ISSN: 1523-6838.

Danielski M, Ikizler TA, McMonagle E, Kane JC, Pupim L, Morrow J, Himmelfarb J. Linkage of hypoalbuminemia, inflammation, and oxidative stress in patients receiving maintenance hemodialysis therapy. Am. J. Kidney Dis. 2003 Aug; 42(2): 286-94. PMID: 12900810, PII: S027263860300653X, ISSN: 1523-6838.

Pupim LB, Ikizler TA. Uremic malnutrition: new insights into an old problem. Semin Dial. 2003 May; 16(3): 224-32. PMID: 12753685, PII: 16046, ISSN: 0894-0959.

Yildiz A, Oflaz H, Pusuroglu H, Mercanoglu F, Genchallac H, Akkaya V, Ikizler TA, Sever MS. Left ventricular hypertrophy and endothelial dysfunction in chronic hemodialysis patients. Am. J. Kidney Dis. 2003 Mar; 41(3): 616-23. PMID: 12612985, PII: S0272638602692303, DOI: 10.1053/ajkd.2003.50123, ISSN: 1523-6838.

Neyra R, Chen KY, Sun M, Shyr Y, Hakim RM, Ikizler TA. Increased resting energy expenditure in patients with end-stage renal disease. JPEN J Parenter Enteral Nutr. 2003 Jan; 27(1): 36-42. PMID: 12549596, ISSN: 0148-6071.

Caglar K, Hakim RM, Ikizler TA. Approaches to the reversal of malnutrition, inflammation, and atherosclerosis in end-stage renal disease. Nutr. Rev. 2002 Nov; 60(11): 378-87. PMID: 12462522, ISSN: 0029-6643.

Himmelfarb J, Stenvinkel P, Ikizler TA, Hakim RM. The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia. Kidney Int. 2002 Nov; 62(5): 1524-38. PMID: 12371953, PII: kid600, DOI: 10.1046/j.1523-1755.2002.00600.x, ISSN: 0085-2538.

Caglar K, Peng Y, Pupim LB, Flakoll PJ, Levenhagen D, Hakim RM, Ikizler TA. Inflammatory signals associated with hemodialysis. Kidney Int. 2002 Oct; 62(4): 1408-16. PMID: 12234313, PII: kid556, DOI: 10.1111/j.1523-1755.2002.kid556.x, ISSN: 0085-2538.

Ikizler TA, Morrow JD, Roberts LJ, Evanson JA, Becker B, Hakim RM, Shyr Y, Himmelfarb J. Plasma F2-isoprostane levels are elevated in chronic hemodialysis patients. Clin. Nephrol. 2002 Sep; 58(3): 190-7. PMID: 12356187, ISSN: 0301-0430.

Caglar K, Fedje L, Dimmitt R, Hakim RM, Shyr Y, Ikizler TA. Therapeutic effects of oral nutritional supplementation during hemodialysis. Kidney Int. 2002 Sep; 62(3): 1054-9. PMID: 12164890, PII: kid530, DOI: 10.1046/j.1523-1755.2002.00530.x, ISSN: 0085-2538.

Pupim LB, Flakoll PJ, Brouillette JR, Levenhagen DK, Hakim RM, Ikizler TA. Intradialytic parenteral nutrition improves protein and energy homeostasis in chronic hemodialysis patients. J. Clin. Invest. 2002 Aug; 110(4): 483-92. PMID: 12189242, PMCID: PMC150418, DOI: 10.1172/JCI15449, ISSN: 0021-9738.

Pupim LB, Kent P, Caglar K, Shyr Y, Hakim RM, Ikizler TA. Improvement in nutritional parameters after initiation of chronic hemodialysis. Am. J. Kidney Dis. 2002 Jul; 40(1): 143-51. PMID: 12087572, PII: S0272-6386(02)00018-5, DOI: 10.1053/ajkd.2002.33923, ISSN: 1523-6838.

Ikizler TA. Epidemiology of vascular disease in renal failure. Blood Purif. 2002; 20(1): 6-10. PMID: 11803153, PII: bpu20006, ISSN: 0253-5068.

Himmelfarb J, Evanson J, Hakim RM, Freedman S, Shyr Y, Ikizler TA. Urea volume of distribution exceeds total body water in patients with acute renal failure. Kidney Int. 2002 Jan; 61(1): 317-23. PMID: 11786114, PII: kid118, DOI: 10.1046/j.1523-1755.2002.00118.x, ISSN: 0085-2538.

Ikizler TA, Pupim LB, Brouillette JR, Levenhagen DK, Farmer K, Hakim RM, Flakoll PJ. Hemodialysis stimulates muscle and whole body protein loss and alters substrate oxidation. Am. J. Physiol. Endocrinol. Metab. 2002 Jan; 282(1): E107-16. PMID: 11739090, ISSN: 0193-1849.

Saadeh E, Ikizler TA, Shyr Y, Hakim RM, Himmelfarb J. Recombinant human growth hormone in patients with acute renal failure. J Ren Nutr. 2001 Oct; 11(4): 212-9. PMID: 11680002, PII: S1051227601815582, ISSN: 1051-2276.

McCarley P, Wingard RL, Shyr Y, Pettus W, Hakim RM, Ikizler TA. Vascular access blood flow monitoring reduces access morbidity and costs. Kidney Int. 2001 Sep; 60(3): 1164-72. PMID: 11532113, PII: kid914, DOI: 10.1046/j.1523-1755.2001.0600031164.x, ISSN: 0085-2538.

Hakim RM, Ikizler TA. Use of vascular access blood flow to evaluate vascular access [letter]. Am. J. Kidney Dis. 2001 Feb; 37(2): 451-2. PMID: 11157393, PII: S0272638601620973, ISSN: 1523-6838.

T. Alp Ikizler. Nutrition and Renal Failure. Primer in Kidney Diseases 3rd edition Greenberg Editor. 2001; 3rd Ed.: 420-5.

Neyra NR, Hakim RM, Shyr Y, Ikizler TA. Serum transferrin and serum prealbumin are early predictors of serum albumin in chronic hemodialysis patients. J Ren Nutr. 2000 Oct; 10(4): 184-90. PMID: 11070145, PII: S1051227600471487, ISSN: 1051-2276.

Bergström J, Lindholm B, Lacson E, Owen W, Lowrie EG, Glassock RJ, Ikizler TA, Wessels FJ, Moldawer LL, Wanner C, Zimmermann J. What are the causes and consequences of the chronic inflammatory state in chronic dialysis patients?. Semin Dial. 2000 May; 13(3): 163-75. PMID: 10833777, ISSN: 0894-0959.

Himmelfarb J, Ikizler TA. Quantitating urea removal in patients with acute renal failure: lost art or forgotten science?. Semin Dial. 2000 May; 13(3): 147-9. PMID: 10833772, ISSN: 0894-0959.

Matsuo K, Ikizler TA, Hoover RL, Nakamoto M, Yasunaga C, Pupim LB, Hakim RM. Transforming growth factor-beta is involved in the pathogenesis of dialysis-related amyloidosis. Kidney Int. 2000 Feb; 57(2): 697-708. PMID: 10652049, PII: kid892, DOI: 10.1046/j.1523-1755.2000.00892.x, ISSN: 0085-2538.

T. Alp Ikizler and Jonathan Himmelfarb. Nutritional Complications in Chronic Hemo- and Peritoneal Dialysis Patients In Complications of Dialysis. Mehta & Lamiere Editors. 2000.

T. Alp Ikizler and Raymond M. Hakim. Parenteral Nutrition and Renal failure. Clinical Nutrition: Parenteral Nutrition Rombeau and Rolandelli Editors. 2000; 3rd Ed.

Rehman SU, Pupim LB, Shyr Y, Hakim R, Ikizler TA. Intradialytic serial vascular access flow measurements. Am. J. Kidney Dis. 1999 Sep; 34(3): 471-7. PMID: 10469857, PII: S0272-6386(99)70074-0, DOI: 10.1053/AJKD03400471, ISSN: 1523-6838.

Pupim LB, Kent P, Ikizler TA. Bioelectrical impedance analysis in dialysis patients. Miner Electrolyte Metab. 1999 Jul; 25(4-6): 400-6. PMID: 10681674, PII: 57482, DOI: 57482, ISSN: 0378-0392.

Ikizler TA, Wingard RL, Harvell J, Shyr Y, Hakim RM. Association of morbidity with markers of nutrition and inflammation in chronic hemodialysis patients: a prospective study. Kidney Int. 1999 May; 55(5): 1945-51. PMID: 10231458, DOI: 10.1046/j.1523-1755.1999.00410.x, ISSN: 0085-2538.

Evanson JA, Ikizler TA, Wingard R, Knights S, Shyr Y, Schulman G, Himmelfarb J, Hakim RM. Measurement of the delivery of dialysis in acute renal failure. Kidney Int. 1999 Apr; 55(4): 1501-8. PMID: 10201016, DOI: 10.1046/j.1523-1755.1999.00355.x, ISSN: 0085-2538.

Neyra NR, Ikizler TA, May RE, Himmelfarb J, Schulman G, Shyr Y, Hakim RM. Change in access blood flow over time predicts vascular access thrombosis. Kidney Int. 1998 Nov; 54(5): 1714-9. PMID: 9844149, DOI: 10.1046/j.1523-1755.1998.00145.x, ISSN: 0085-2538.

Evanson JA, Himmelfarb J, Wingard R, Knights S, Shyr Y, Schulman G, Ikizler TA, Hakim RM. Prescribed versus delivered dialysis in acute renal failure patients. Am. J. Kidney Dis. 1998 Nov; 32(5): 731-8. PMID: 9820441, PII: S0272638698003102, ISSN: 1523-6838.

May RE, Himmelfarb J, Yenicesu M, Knights S, Ikizler TA, Schulman G, Hernanz-Schulman M, Shyr Y, Hakim RM. Predictive measures of vascular access thrombosis: a prospective study. Kidney Int. 1997 Dec; 52(6): 1656-62. PMID: 9407514, ISSN: 0085-2538.

Ikizler TA, Schulman G. Adequacy of dialysis. Kidney Int. Suppl. 1997 Nov; 62: S96-100. PMID: 9350693, ISSN: 0098-6577.

Ikizler TA, Himmelfarb J. Nutrition in acute renal failure patients. Adv Ren Replace Ther. 1997 Apr; 4(2 Suppl 1): 54-63. PMID: 9113241, ISSN: 1073-4449.

Ismail N, Ikizler TA. Erythropoietin-induced hypertension. J Med Liban. 1997; 45(1): 25-30. PMID: 9421942, ISSN: 0023-9852.

Ikizler TA, Wingard RL, Sun M, Harvell J, Parker RA, Hakim RM. Increased energy expenditure in hemodialysis patients. J. Am. Soc. Nephrol. 1996 Dec; 7(12): 2646-53. PMID: 8989743, ISSN: 1046-6673.

Ikizler TA, Greene JH, Yenicesu M, Schulman G, Wingard RL, Hakim RM. Nitrogen balance in hospitalized chronic hemodialysis patients. Kidney Int. Suppl. 1996 Dec; 57: S53-6. PMID: 8941922, ISSN: 0098-6577.

Ikizler TA, Hakim RM. Nutrition in end-stage renal disease. Kidney Int. 1996 Aug; 50(2): 343-57. PMID: 8840260, ISSN: 0085-2538.

Ikizler TA, Wingard RL, Flakoll PJ, Schulman G, Parker RA, Hakim RM. Effects of recombinant human growth hormone on plasma and dialysate amino acid profiles in CAPD patients. Kidney Int. 1996 Jul; 50(1): 229-34. PMID: 8807592, ISSN: 0085-2538.

Parker TF, Wingard RL, Husni L, Ikizler TA, Parker RA, Hakim RM. Effect of the membrane biocompatibility on nutritional parameters in chronic hemodialysis patients. Kidney Int. 1996 Feb; 49(2): 551-6. PMID: 8821843, ISSN: 0085-2538.

Ikizler TA, Greene JH, Wingard RL, Parker RA, Hakim RM. Spontaneous dietary protein intake during progression of chronic renal failure. J. Am. Soc. Nephrol. 1995 Nov; 6(5): 1386-91. PMID: 8589313, ISSN: 1046-6673.

Ikizler TA, Wingard RL, Hakim RM. Interventions to treat malnutrition in dialysis patients: the role of the dose of dialysis, intradialytic parenteral nutrition, and growth hormone. Am. J. Kidney Dis. 1995 Jul; 26(1): 256-65. PMID: 7611260, PII: 0272-6386(95)90181-7, ISSN: 0272-6386.

Ikizler TA, Wingard RL, Hakim RM. Malnutrition in peritoneal dialysis patients: etiologic factors and treatment options. Perit Dial Int. 1995; 15(5 Suppl): S63-6. PMID: 7578490, ISSN: 0896-8608.

Ikizler TA, Wingard RL, Breyer JA, Schulman G, Parker RA, Hakim RM. Short-term effects of recombinant human growth hormone in CAPD patients. Kidney Int. 1994 Oct; 46(4): 1178-83. PMID: 7861714, ISSN: 0085-2538.

Ikizler TA, Flakoll PJ, Parker RA, Hakim RM. Amino acid and albumin losses during hemodialysis. Kidney Int. 1994 Sep; 46(3): 830-7. PMID: 7996804, ISSN: 0085-2538.

Ikizler, A. Eran, A. Obek. Effects of intravenous amino acid treatment in patients with chronic renal failure. Sisli Etfal Medical Bulletin. 1992; 92/1((Vol.26)): 40-4.