Lorraine B. Ware, M.D.


Faculty Appointments
Professor of Medicine Professor of Pathology, Microbiology and Immunology
M.D., Johns Hopkins University, Baltimore, MarylandB.A., Claremont Mckenna College, Claremont, California
Office Address
T-1218 MCN
1161 21st Avenue S
Nashville, TN 37232-2650
Research Description
Our lab does basic, translational and clinical research on the role of the alveolar epithelium in the pathogenesis and resolution of acute lung injury and the acute respiratory distress syndrome. Current projects include studies of the role of cell-free hemoglobin in the pathogenesis of lung epithelial injury in acute lung injury, investigation of the role of alveolar epithelium in modulating intra-alveolar fibrin deposition in the injured lung, translational studies of biomarkers for diagnosis and prognosis in acute lung injury, and studies of donor management for lung transplantation.
Research Keywords
Translational research in acute lung injury and lung transplantation
Clinical Research Keywords
acute lung injury, ARDS, pulmonary edema, acute respiratory failure, sepsis, coagulation, fibrinolysis, biomarker, proteomics, lung transplantation
Hughes CG, Pandharipande PP, Thompson JL, Chandrasekhar R, Ware LB, Ely EW, Girard TD. Endothelial Activation and Blood-Brain Barrier Injury as Risk Factors for Delirium in Critically Ill Patients. Crit. Care Med. 2016 Sep; 44(9): e809-17. PMID: 27088157, PMCID: PMC4987204, DOI: 10.1097/CCM.0000000000001739, ISSN: 1530-0293.

Zhao B, Lu Q, Cheng Y, Belcher JM, Siew ED, Leaf DE, Body SC, Fox AA, Waikar SW, Collard CD, Thiessen-Philbrook H, Ikizler TA, Ware LB, Edelstein CL, Garg AX, Choi M, Schaub JA, Zhao H, Lifton RP, Parikh CR, . A Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms for Acute Kidney Injury. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Aug 8/30/2016; PMID: 27576016, DOI: 10.1164/rccm.201603-0518OC, ISSN: 1535-4970.

Famous KR, Delucchi K, Ware LB, Kangelaris KN, Liu KD, Thompson BT, Calfee CS. ARDS Subphenotypes Respond Differently to Randomized Fluid Management Strategy. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Aug 8/11/2016; PMID: 27513822, DOI: 10.1164/rccm.201603-0645OC, ISSN: 1535-4970.

Kangelaris KN, Ware LB, Matthay MA, Calfee CS. The authors reply. Crit. Care Med. 2016 Aug; 44(8): e771. PMID: 27428150, PII: 00003246-201608000-00064, DOI: 10.1097/CCM.0000000000001909, ISSN: 1530-0293.

Kangelaris KN, Ware LB, Matthay MA, Calfee CS. The authors reply. Crit. Care Med. 2016 Aug; 44(8): e769-70. PMID: 27428148, PII: 00003246-201608000-00062, DOI: 10.1097/CCM.0000000000001910, ISSN: 1530-0293.

Kor DJ, Carter RE, Park PK, Festic E, Banner-Goodspeed VM, Hinds R, Talmor D, Gajic O, Ware LB, Gong MN, . Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial. JAMA. 2016 Jun 6/14/2016; 315(22): 2406-14. PMID: 27179988, PII: 2522739, DOI: 10.1001/jama.2016.6330, ISSN: 1538-3598.

Ware LB, Zhao Z, Koyama T, May AK, Matthay MA, Lurmann FW, Balmes JR, Calfee CS. Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. 2016 May 5/15/2016; 193(10): 1143-50. PMID: 26681363, PMCID: PMC4872663, DOI: 10.1164/rccm.201507-1418OC, ISSN: 1535-4970.

Ware LB, Calfee CS. Biomarkers of ARDS: what's new?. Intensive Care Med [print-electronic]. 2016 May; 42(5): 797-9. PMID: 26174184, PII: 10.1007/s00134-015-3973-0, DOI: 10.1007/s00134-015-3973-0, ISSN: 1432-1238.

Mekontso Dessap A, Ware LB, Bagshaw SM. How could biomarkers of ARDS and AKI drive clinical strategies?. Intensive Care Med [print-electronic]. 2016 May; 42(5): 800-2. PMID: 26821714, PII: 10.1007/s00134-016-4231-9, DOI: 10.1007/s00134-016-4231-9, ISSN: 1432-1238.

Shaver CM, Ware LB. The authors reply [letter]. Crit. Care Med. 2016 May; 44(5): e307. PMID: 27083029, PII: 00003246-201605000-00039, DOI: 10.1097/CCM.0000000000001579, ISSN: 1530-0293.

Bhattacharya M, Kallet RH, Ware LB, Matthay MA. Negative Pressure Pulmonary Edema. Chest [print-electronic]. 2016 Apr 4/7/2016; PMID: 27063348, PII: S0012-3692(16)47573-2, DOI: 10.1016/j.chest.2016.03.043, ISSN: 1931-3543.

Diamond JM, Porteous MK, Jackson Roberts L, Wickersham N, Rushefski M, Kawut SM, Shah RJ, Cantu E, Lederer DJ, Chatterjee S, Lama VN, Bhorade S, Crespo M, McDyer J, Wille K, Orens J, Weinacker A, Arcasoy S, Shah PD, Wilkes DS, Hage C, Palmer SM, Snyder L, Calfee CS, Ware LB, Christie JD, . The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia. J. Heart Lung Transplant [print-electronic]. 2016 Apr; 35(4): 500-7. PMID: 26856667, PMCID: PMC4821817, PII: S1053-2498(16)00007-3, DOI: 10.1016/j.healun.2015.12.012, ISSN: 1557-3117.

McKown AC, Ware LB. Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?. Ann Transl Med. 2016 Apr; 4(7): 145. PMID: 27162795, PMCID: PMC4842401, PII: atm-04-07-145, DOI: 10.21037/atm.2016.03.20, ISSN: 2305-5839.

Shaver CM, Upchurch CP, Janz DR, Grove BS, Putz ND, Wickersham NE, Dikalov SI, Ware LB, Bastarache JA. Cell-free hemoglobin: a novel mediator of acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Mar 3/15/2016; 310(6): L532-41. PMID: 26773065, PMCID: PMC4796260, PII: ajplung.00155.2015, DOI: 10.1152/ajplung.00155.2015, ISSN: 1522-1504.

Mekontso Dessap A, Ware LB, Bouadma L. What's new with biomarker-driven clinical strategy in sepsis and circulatory failure?. Intensive Care Med [print-electronic]. 2016 Mar; 42(3): 418-21. PMID: 26392256, PII: 10.1007/s00134-015-4058-9, DOI: 10.1007/s00134-015-4058-9, ISSN: 1432-1238.

Cantu E, Suzuki Y, Diamond JM, Ellis J, Tiwari J, Beduhn B, Nellen JR, Shah R, Meyer NJ, Lederer DJ, Kawut SM, Palmer SM, Snyder LD, Hartwig MG, Lama VN, Bhorade S, Crespo M, Demissie E, Wille K, Orens J, Shah PD, Weinacker A, Weill D, Wilkes D, Roe D, Ware LB, Wang F, Feng R, Christie JD, . Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk. Am. J. Transplant [print-electronic]. 2016 Mar; 16(3): 833-40. PMID: 26663441, PMCID: PMC4767612, DOI: 10.1111/ajt.13525, ISSN: 1600-6143.

Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay MA, Calfee CS. Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome. Crit. Care Med. 2016 Jan; 44(1): 120-9. PMID: 26474112, PMCID: PMC4774861, DOI: 10.1097/CCM.0000000000001359, ISSN: 1530-0293.

Shaver CM, Grove BS, Clune JK, Mackman N, Ware LB, Bastarache JA. Myeloid tissue factor does not modulate lung inflammation or permeability during experimental acute lung injury. Sci Rep. 2016; 6: 22249. PMID: 26924425, PMCID: PMC4770302, PII: srep22249, DOI: 10.1038/srep22249, ISSN: 2045-2322.

Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA, . Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Crit Care. 2016; 20(1): 151. PMID: 27215212, PMCID: PMC4876559, PII: 10.1186/s13054-016-1330-5, DOI: 10.1186/s13054-016-1330-5, ISSN: 1466-609X.

Du RH, Richmond BW, Blackwell TS, Cates JM, Massion PP, Ware LB, Lee JW, Kononov AV, Lawson WE, Blackwell TS, Polosukhin VV. Secretory IgA from submucosal glands does not compensate for its airway surface deficiency in chronic obstructive pulmonary disease. Virchows Arch [print-electronic]. 2015 Dec; 467(6): 657-65. PMID: 26432569, PII: 10.1007/s00428-015-1854-0, DOI: 10.1007/s00428-015-1854-0, ISSN: 1432-2307.

Chen W, Ware LB. Prognostic factors in the acute respiratory distress syndrome. Clin Transl Med [print-electronic]. 2015 Dec; 4(1): 65. PMID: 26162279, PMCID: PMC4534483, DOI: 10.1186/s40169-015-0065-2, ISSN: 2001-1326.

Shaver CM, Grove BS, Putz ND, Clune JK, Lawson WE, Carnahan RH, Mackman N, Ware LB, Bastarache JA. Regulation of alveolar procoagulant activity and permeability in direct acute lung injury by lung epithelial tissue factor. Am. J. Respir. Cell Mol. Biol. 2015 Nov; 53(5): 719-27. PMID: 25884207, PMCID: PMC4742948, DOI: 10.1165/rcmb.2014-0179OC, ISSN: 1535-4989.

Shaver CM, Chen W, Janz DR, May AK, Darbar D, Bernard GR, Bastarache JA, Ware LB. Atrial Fibrillation Is an Independent Predictor of Mortality in Critically Ill Patients. Crit. Care Med. 2015 Oct; 43(10): 2104-11. PMID: 26154932, PMCID: PMC4725582, DOI: 10.1097/CCM.0000000000001166, ISSN: 1530-0293.

Chen W, Chen YY, Tsai CF, Chen SC, Lin MS, Ware LB, Chen CM. Incidence and Outcomes of Acute Respiratory Distress Syndrome: A Nationwide Registry-Based Study in Taiwan, 1997 to 2011. Medicine (Baltimore). 2015 Oct; 94(43): e1849. PMID: 26512593, PMCID: PMC4985407, PII: 00005792-201510270-00048, DOI: 10.1097/MD.0000000000001849, ISSN: 1536-5964.

Parr SK, Bian A, K Shintani A, Ware LB, Alp Ikizler T, Siew ED. The Authors Reply [letter]. Kidney Int. 2015 Sep; 88(3): 639-40. PMID: 26323077, PMCID: PMC4587760, PII: S2157-1716(15)32229-2, DOI: 10.1038/ki.2015.222, ISSN: 1523-1755.

Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB. Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome. Crit. Care Med. 2015 Sep; 43(9): 1790-7. PMID: 26010690, PMCID: PMC4737582, DOI: 10.1097/CCM.0000000000001089, ISSN: 1530-0293.

Shah RJ, Diamond JM, Cantu E, Flesch J, Lee JC, Lederer DJ, Lama VN, Orens J, Weinacker A, Wilkes DS, Roe D, Bhorade S, Wille KM, Ware LB, Palmer SM, Crespo M, Demissie E, Sonnet J, Shah A, Kawut SM, Bellamy SL, Localio AR, Christie JD. Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation. Am. J. Transplant [print-electronic]. 2015 Aug; 15(8): 2188-96. PMID: 25877792, PMCID: PMC4721238, DOI: 10.1111/ajt.13262, ISSN: 1600-6143.

Matthay MA, Ware LB. Resolution of Alveolar Edema in Acute Respiratory Distress Syndrome. Physiology and Biology [editorial]. Am. J. Respir. Crit. Care Med. 2015 Jul 7/15/2015; 192(2): 124-5. PMID: 26177166, DOI: 10.1164/rccm.201505-0938ED, ISSN: 1535-4970.

Chen W, Janz DR, Bastarache JA, May AK, O'Neal HR, Bernard GR, Ware LB. Prehospital aspirin use is associated with reduced risk of acute respiratory distress syndrome in critically ill patients: a propensity-adjusted analysis. Crit. Care Med. 2015 Apr; 43(4): 801-7. PMID: 25559436, PMCID: PMC4359645, DOI: 10.1097/CCM.0000000000000789, ISSN: 1530-0293.

Janz DR, Bastarache JA, Rice TW, Bernard GR, Warren MA, Wickersham N, Sills G, Oates JA, Roberts LJ, Ware LB, . Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial. Crit. Care Med. 2015 Mar; 43(3): 534-41. PMID: 25474535, PMCID: PMC4336619, DOI: 10.1097/CCM.0000000000000718, ISSN: 1530-0293.

Parr SK, Clark AJ, Bian A, Shintani AK, Wickersham NE, Ware LB, Ikizler TA, Siew ED. Urinary L-FABP predicts poor outcomes in critically ill patients with early acute kidney injury. Kidney Int [print-electronic]. 2015 Mar; 87(3): 640-8. PMID: 25229339, PMCID: PMC4344867, PII: S0085-2538(15)30159-9, DOI: 10.1038/ki.2014.301, ISSN: 1523-1755.

Bastarache JA, Wynn JL, Ware LB. Fanning the Fire: Can Methemoglobin Enhance Neutrophil Activation?. EBioMedicine. 2015 Mar; 2(3): 184-5. PMID: 26137557, PMCID: PMC4485487, PII: S2352-3964(15)00043-2, DOI: 10.1016/j.ebiom.2015.01.019, ISSN: 2352-3964.

Kropski JA, Pritchett JM, Zoz DF, Crossno PF, Markin C, Garnett ET, Degryse AL, Mitchell DB, Polosukhin VV, Rickman OB, Choi L, Cheng DS, McConaha ME, Jones BR, Gleaves LA, McMahon FB, Worrell JA, Solus JF, Ware LB, Lee JW, Massion PP, Zaynagetdinov R, White ES, Kurtis JD, Johnson JE, Groshong SD, Lancaster LH, Young LR, Steele MP, Phillips Iii JA, Cogan JD, Loyd JE, Lawson WE, Blackwell TS. Extensive phenotyping of individuals at risk for familial interstitial pneumonia reveals clues to the pathogenesis of interstitial lung disease. Am. J. Respir. Crit. Care Med. 2015 Feb 2/15/2015; 191(4): 417-26. PMID: 25389906, PMCID: PMC4351594, DOI: 10.1164/rccm.201406-1162OC, ISSN: 1535-4970.

Janz DR, Ware LB. The role of red blood cells and cell-free hemoglobin in the pathogenesis of ARDS. J Intensive Care. 2015; 3: 20. PMID: 26933497, PMCID: PMC4772369, PII: 86, DOI: 10.1186/s40560-015-0086-3, ISSN: 2052-0492.

Ware LB. Transfusion-induced lung endothelial injury: a DAMP death? [editorial]. Am. J. Respir. Crit. Care Med. 2014 Dec 12/15/2014; 190(12): 1331-2. PMID: 25496097, DOI: 10.1164/rccm.201411-2047ED, ISSN: 1535-4970.

Brittain EL, Janz DR, Austin ED, Bastarache JA, Wheeler LA, Ware LB, Hemnes AR. Elevation of plasma cell-free hemoglobin in pulmonary arterial hypertension. Chest. 2014 Dec; 146(6): 1478-85. PMID: 24945582, PMCID: PMC4251612, PII: 1883303, DOI: 10.1378/chest.14-0809, ISSN: 1931-3543.

Ware LB, Bastarache JA, Calfee CS. ARDS: new mechanistic insights, new therapeutic directions [editorial]. Clin. Chest Med [print-electronic]. 2014 Dec; 35(4): xv-xvi. PMID: 25453428, PII: S0272-5231(14)00086-0, DOI: 10.1016/j.ccm.2014.09.001, ISSN: 1557-8216.

Janz DR, Ware LB. Approach to the patient with the acute respiratory distress syndrome. Clin. Chest Med [print-electronic]. 2014 Dec; 35(4): 685-96. PMID: 25453418, PMCID: PMC4254536, PII: S0272-5231(14)00076-8, DOI: 10.1016/j.ccm.2014.08.007, ISSN: 1557-8216.

Walter J, Ware LB, Matthay MA. Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis. Lancet Respir Med [print-electronic]. 2014 Dec; 2(12): 1016-26. PMID: 25465643, PII: S2213-2600(14)70217-6, DOI: 10.1016/S2213-2600(14)70217-6, ISSN: 2213-2619.

Sowards KJ, Mukherjee K, Norris PR, Shintani A, Ware LB, Roberts LJ, May AK. Elevated serum creatine phosphokinase is associated with mortality and inotropic requirement in critically injured adults. Injury. 2014 Dec; 45(12): 2096-100. PMID: 25441175, PMCID: PMC4877131, PII: S0020-1383(14)00448-3, DOI: 10.1016/j.injury.2014.09.009, ISSN: 1879-0267.

Walter JM, Wilson J, Ware LB. Biomarkers in acute respiratory distress syndrome: from pathobiology to improving patient care. Expert Rev Respir Med [print-electronic]. 2014 Oct; 8(5): 573-86. PMID: 24875533, DOI: 10.1586/17476348.2014.924073, ISSN: 1747-6356.

Ware LB, Lee JW, Wickersham N, Nguyen J, Matthay MA, Calfee CS, . Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs. Am. J. Transplant [print-electronic]. 2014 Oct; 14(10): 2295-302. PMID: 25146497, PMCID: PMC4169304, DOI: 10.1111/ajt.12853, ISSN: 1600-6143.

West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM. Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension. Am. J. Physiol., Cell Physiol [print-electronic]. 2014 Sep 9/1/2014; 307(5): C415-30. PMID: 24871858, PMCID: PMC4154073, PII: ajpcell.00057.2014, DOI: 10.1152/ajpcell.00057.2014, ISSN: 1522-1563.

Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA, . Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med [print-electronic]. 2014 Aug; 2(8): 611-20. PMID: 24853585, PMCID: PMC4154544, PII: S2213-2600(14)70097-9, DOI: 10.1016/S2213-2600(14)70097-9, ISSN: 2213-2619.

Shah RJ, Emtiazjoo AM, Diamond JM, Smith PA, Roe DW, Wille KM, Orens JB, Ware LB, Weinacker A, Lama VN, Bhorade SM, Palmer SM, Crespo M, Lederer DJ, Cantu E, Eckert GJ, Christie JD, Wilkes DS. Plasma complement levels are associated with primary graft dysfunction and mortality after lung transplantation [letter]. Am. J. Respir. Crit. Care Med. 2014 Jun 6/15/2014; 189(12): 1564-7. PMID: 24930532, PMCID: PMC4226014, DOI: 10.1164/rccm.201312-2121LE, ISSN: 1535-4970.

Bastarache JA, Koyama T, Wickersham NE, Ware LB. Validation of a multiplex electrochemiluminescent immunoassay platform in human and mouse samples. J. Immunol. Methods [print-electronic]. 2014 Jun; 408: 13-23. PMID: 24768796, PMCID: PMC4120713, PII: S0022-1759(14)00123-9, DOI: 10.1016/j.jim.2014.04.006, ISSN: 1872-7905.

Reilly JP, Bellamy S, Shashaty MG, Gallop R, Meyer NJ, Lanken PN, Kaplan S, Holena DN, May AK, Ware LB, Christie JD. Heterogeneous phenotypes of acute respiratory distress syndrome after major trauma. Ann Am Thorac Soc. 2014 Jun; 11(5): 728-36. PMID: 24712298, PMCID: PMC4225810, DOI: 10.1513/AnnalsATS.201308-280OC, ISSN: 2325-6621.

Ware LB, Landeck M, Koyama T, Zhao Z, Singer J, Kern R, Neidlinger N, Nguyen J, Johnson E, Janz DR, Bernard GR, Lee JW, Matthay MA, . A randomized trial of the effects of nebulized albuterol on pulmonary edema in brain-dead organ donors. Am. J. Transplant. 2014 Mar; 14(3): 621-8. PMID: 24730050, PMCID: PMC3986821, ISSN: 1600-6143.

Janz DR, Ware LB. Plasma biomarkers in acute respiratory distress syndrome: a work in progress* [editorial]. Crit. Care Med. 2014 Mar; 42(3): 755-6. PMID: 24534974, PMCID: PMC4007287, PII: 00003246-201403000-00044, DOI: 10.1097/CCM.0000000000000060, ISSN: 1530-0293.

Diamond JM, Akimova T, Kazi A, Shah RJ, Cantu E, Feng R, Levine MH, Kawut SM, Meyer NJ, Lee JC, Hancock WW, Aplenc R, Ware LB, Palmer SM, Bhorade S, Lama VN, Weinacker A, Orens J, Wille K, Crespo M, Lederer DJ, Arcasoy S, Demissie E, Christie JD, . Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction. Am. J. Respir. Crit. Care Med. 2014 Mar 3/1/2014; 189(5): 567-75. PMID: 24467603, PMCID: PMC3977709, DOI: 10.1164/rccm.201307-1283OC, ISSN: 1535-4970.

Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN. One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome. Intensive Care Med [print-electronic]. 2014 Mar; 40(3): 388-96. PMID: 24435201, PMCID: PMC3943651, DOI: 10.1007/s00134-013-3186-3, ISSN: 1432-1238.

Shah RJ, Wickersham N, Lederer DJ, Palmer SM, Cantu E, Diamond JM, Kawut SM, Lama VN, Bhorade S, Crespo M, Demissie E, Sonett J, Wille K, Orens J, Weinacker A, Shah P, Arcasoy S, Wilkes DS, Christie JD, Ware LB, . Preoperative plasma club (clara) cell secretory protein levels are associated with primary graft dysfunction after lung transplantation. Am. J. Transplant [print-electronic]. 2014 Feb; 14(2): 446-52. PMID: 24400993, PMCID: PMC3946770, DOI: 10.1111/ajt.12541, ISSN: 1600-6143.

Bastarache JA, Roberts LJ, Ware LB. Thinking outside the cell: how cell-free hemoglobin can potentiate acute lung injury [editorial]. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2014 Feb; 306(3): L231-2. PMID: 24337924, PMCID: PMC3920200, PII: ajplung.00355.2013, DOI: 10.1152/ajplung.00355.2013, ISSN: 1522-1504.

Chen Q, Wu H, Ware LB, Koyama T. A Bayesian Approach for the Cox Proportional Hazards Model with Covariates Subject to Detection Limit. Int J Stat Med Res. 2014 Jan 1/31/2014; 3(1): 32-43. PMID: 24772198, PMCID: PMC3998726, DOI: 10.6000/1929-6029.2014.03.01.5, ISSN: 1929-6029.

Barnett N, Zhao Z, Koyama T, Janz DR, Wang CY, May AK, Bernard GR, Ware LB. Vitamin D deficiency and risk of acute lung injury in severe sepsis and severe trauma: a case-control study. Ann Intensive Care. 2014; 4(1): 5. PMID: 24559079, PMCID: PMC3944729, PII: 2110-5820-4-5, DOI: 10.1186/2110-5820-4-5, ISSN: 2110-5820.

Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB. Is there still a role for the lung injury score in the era of the Berlin definition ARDS?. Ann Intensive Care. 2014; 4(1): 4. PMID: 24533450, PMCID: PMC3931496, PII: 2110-5820-4-4, DOI: 10.1186/2110-5820-4-4, ISSN: 2110-5820.

Siew ED, Ware LB, Bian A, Shintani A, Eden SK, Wickersham N, Cripps B, Ikizler TA. Distinct injury markers for the early detection and prognosis of incident acute kidney injury in critically ill adults with preserved kidney function. Kidney Int [print-electronic]. 2013 Oct; 84(4): 786-94. PMID: 23698227, PMCID: PMC3788840, PII: S0085-2538(15)56029-8, DOI: 10.1038/ki.2013.174, ISSN: 1523-1755.

Janz DR, Ware LB. Biomarkers of ALI/ARDS: pathogenesis, discovery, and relevance to clinical trials. Semin Respir Crit Care Med [print-electronic]. 2013 Aug; 34(4): 537-48. PMID: 23934723, DOI: 10.1055/s-0033-1351124, ISSN: 1098-9048.

Ware LB, Herridge M. Acute lung injury. Semin Respir Crit Care Med [print-electronic]. 2013 Aug; 34(4): 439-40. PMID: 23934712, DOI: 10.1055/s-0033-1351163, ISSN: 1098-9048.

Ware LB. Autopsy in ARDS: insights into natural history. Lancet Respir Med [print-electronic]. 2013 Jul; 1(5): 352-4. PMID: 24429190, PII: S2213-2600(13)70093-6, DOI: 10.1016/S2213-2600(13)70093-6, ISSN: 2213-2619.

Sebag SC, Bastarache JA, Ware LB. Mechanical stretch inhibits lipopolysaccharide-induced keratinocyte-derived chemokine and tissue factor expression while increasing procoagulant activity in murine lung epithelial cells. J. Biol. Chem [print-electronic]. 2013 Mar 3/15/2013; 288(11): 7875-84. PMID: 23362270, PMCID: PMC3597825, PII: M112.403220, DOI: 10.1074/jbc.M112.403220, ISSN: 1083-351X.

Janz DR, Bastarache JA, Peterson JF, Sills G, Wickersham N, May AK, Roberts LJ, Ware LB. Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: an observational study. Crit. Care Med. 2013 Mar; 41(3): 784-90. PMID: 23314583, PMCID: PMC3578977, DOI: 10.1097/CCM.0b013e3182741a54, ISSN: 1530-0293.

Ware LB. Acute respiratory distress syndrome: from TRALI to trials. The Lancet. Respiratory medicine [print-electronic]. 2013 Mar; 1(1) Sect. e1-2.

Janz DR, Bastarache JA, Sills G, Wickersham N, May AK, Bernard GR, Ware LB. Association between haptoglobin, hemopexin and mortality in adults with sepsis. Crit Care. 2013; 17(6): R272. PMID: 24225252, PMCID: PMC4056258, PII: cc13108, DOI: 10.1186/cc13108, ISSN: 1466-609X.

Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR, May AK, Calfee CS, Matthay MA. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit Care. 2013; 17(5): R253. PMID: 24156650, PMCID: PMC4056313, PII: cc13080, DOI: 10.1186/cc13080, ISSN: 1466-609X.

Janz DR, Zhao Z, Koyama T, May AK, Bernard GR, Bastarache JA, Young PP, Ware LB. Longer storage duration of red blood cells is associated with an increased risk of acute lung injury in patients with sepsis. Ann Intensive Care. 2013; 3(1): 33. PMID: 24059842, PMCID: PMC3848804, PII: 2110-5820-3-33, DOI: 10.1186/2110-5820-3-33, ISSN: 2110-5820.

Bastarache JA, Sebag SC, Clune JK, Grove BS, Lawson WE, Janz DR, Roberts LJ, Dworski R, Mackman N, Ware LB. Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. Thorax [print-electronic]. 2012 Dec; 67(12): 1032-9. PMID: 23033361, PMCID: PMC3652432, PII: thoraxjnl-2012-201781, DOI: 10.1136/thoraxjnl-2012-201781, ISSN: 1468-3296.

Girard TD, Ware LB, Bernard GR, Pandharipande PP, Thompson JL, Shintani AK, Jackson JC, Dittus RS, Ely EW. Associations of markers of inflammation and coagulation with delirium during critical illness. Intensive Care Med [print-electronic]. 2012 Dec; 38(12): 1965-73. PMID: 22903241, PMCID: PMC3606929, DOI: 10.1007/s00134-012-2678-x, ISSN: 1432-1238.

Bastarache JA, Ware LB, Girard TD, Wheeler AP, Rice TW. Markers of inflammation and coagulation may be modulated by enteral feeding strategy. JPEN J Parenter Enteral Nutr [print-electronic]. 2012 Nov; 36(6): 732-40. PMID: 22318965, PMCID: PMC3726194, PII: 0148607111433054, DOI: 10.1177/0148607111433054, ISSN: 0148-6071.

Zeyed YF, Bastarache JA, Matthay MA, Ware LB. The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2012 Sep 9/15/2012; 303(6): L550-5. PMID: 22821995, PMCID: PMC3468480, PII: ajplung.00190.2012, DOI: 10.1152/ajplung.00190.2012, ISSN: 1522-1504.

Ware LB, Neyrinck A, O'Neal HR, Lee JW, Landeck M, Johnson E, Calfee CS, Matthay MA, . Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors. Clin Transplant [print-electronic]. 2012 Sep; 26(5): 665-71. PMID: 22324977, PMCID: PMC3642873, DOI: 10.1111/j.1399-0012.2011.01591.x, ISSN: 1399-0012.

Bastarache JA, Diamond JM, Kawut SM, Lederer DJ, Ware LB, Christie JD. Postoperative estradiol levels associate with development of primary graft dysfunction in lung transplantation patients. Gend Med [print-electronic]. 2012 Jun; 9(3): 154-65. PMID: 22361838, PMCID: PMC3374892, PII: S1550-8579(12)00049-6, DOI: 10.1016/j.genm.2012.01.009, ISSN: 1878-7398.

Polosukhin VV, Degryse AL, Newcomb DC, Jones BR, Ware LB, Lee JW, Loyd JE, Blackwell TS, Lawson WE. Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice. Exp. Lung Res. 2012 Apr; 38(3): 135-46. PMID: 22394287, PMCID: PMC4046254, DOI: 10.3109/01902148.2012.658595, ISSN: 1521-0499.

Wu H, Chen Q, Ware LB, Koyama T. A Bayesian Approach for Generalized Linear Models with Explanatory Biomarker Measurement Variables Subject to Detection Limit - an Application to Acute Lung Injury. J Appl Stat [print-electronic]. 2012; 39(8): 1733-47. PMID: 23049157, PMCID: PMC3463110, DOI: 10.1080/02664763.2012.681362, ISSN: 0266-4763.

Bastarache JA, Sebag SC, Grove BS, Ware LB. Interferon-¿ and tumor necrosis factor-a act synergistically to up-regulate tissue factor in alveolar epithelial cells. Exp. Lung Res. 2011 Oct; 37(8): 509-17. PMID: 21913843, PMCID: PMC3652424, DOI: 10.3109/01902148.2011.605512, ISSN: 1521-0499.

Sebag SC, Bastarache JA, Ware LB. Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndrome. Curr Pharm Biotechnol. 2011 Sep; 12(9): 1481-96. PMID: 21401517, PMCID: PMC3893117, PII: BSP/CPB/E-Pub/000104-12-9, ISSN: 1873-4316.

Polosukhin VV, Cates JM, Lawson WE, Zaynagetdinov R, Milstone AP, Massion PP, Ocak S, Ware LB, Lee JW, Bowler RP, Kononov AV, Randell SH, Blackwell TS. Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med [print-electronic]. 2011 Aug 8/1/2011; 184(3): 317-27. PMID: 21512171, PMCID: PMC3265275, PII: 201010-1629OC, DOI: 10.1164/rccm.201010-1629OC, ISSN: 1535-4970.

Barnett N, Ware LB. Biomarkers in acute lung injury--marking forward progress. Crit Care Clin. 2011 Jul; 27(3): 661-83. PMID: 21742222, PMCID: PMC3134784, PII: S0749-0704(11)00016-9, DOI: 10.1016/j.ccc.2011.04.001, ISSN: 1557-8232.

Ware LB, Fessel JP, May AK, Roberts LJ. Plasma biomarkers of oxidant stress and development of organ failure in severe sepsis. Shock. 2011 Jul; 36(1): 12-7. PMID: 21372753, PMCID: PMC3117035, DOI: 10.1097/SHK.0b013e318217025a, ISSN: 1540-0514.

Bastarache JA, Ong T, Matthay MA, Ware LB. Alveolar fluid clearance is faster in women with acute lung injury compared to men. J Crit Care [print-electronic]. 2011 Jun; 26(3): 249-56. PMID: 20688464, PMCID: PMC2982881, PII: S0883-9441(10)00168-1, DOI: 10.1016/j.jcrc.2010.06.005, ISSN: 1557-8615.

Siew ED, Ware LB, Ikizler TA. Biological markers of acute kidney injury. J. Am. Soc. Nephrol [print-electronic]. 2011 May; 22(5): 810-20. PMID: 21493774, PII: ASN.2010080796, DOI: 10.1681/ASN.2010080796, ISSN: 1533-3450.

Bastarache JA, Koyama T, Wickersham NE, Mitchell DB, Mernaugh RL, Ware LB. Accuracy and reproducibility of a multiplex immunoassay platform: a validation study. J. Immunol. Methods [print-electronic]. 2011 Mar 3/31/2011; 367(1-2): 33-9. PMID: 21277854, PMCID: PMC3108329, PII: S0022-1759(11)00008-1, DOI: 10.1016/j.jim.2011.01.005, ISSN: 1872-7905.

Ware LB, Johnson AC, Zager RA. Renal cortical albumin gene induction and urinary albumin excretion in response to acute kidney injury. Am. J. Physiol. Renal Physiol [print-electronic]. 2011 Mar; 300(3): F628-38. PMID: 21147844, PMCID: PMC3064135, PII: ajprenal.00654.2010, DOI: 10.1152/ajprenal.00654.2010, ISSN: 1522-1466.

Ware LB, Koyama T, Billheimer D, Landeck M, Johnson E, Brady S, Bernard GR, Matthay MA, . Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial. Ann Intensive Care. 2011; 1(1): 20. PMID: 21906362, PMCID: PMC3224478, PII: 2110-5820-1-20, DOI: 10.1186/2110-5820-1-20, ISSN: 2110-5820.

Rice TW, Ware LB, Haponik EF, Chiles C, Wheeler AP, Bernard GR, Steingrub JS, Hite RD, Matthay MA, Wright P, Ely EW, . Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status. Crit Care [print-electronic]. 2011; 15(2): R86. PMID: 21385351, PMCID: PMC3219344, PII: cc10084, DOI: 10.1186/cc10084, ISSN: 1466-609X.

Lee HJ, Joo M, Abdolrasulnia R, Young DG, Choi I, Ware LB, Blackwell TS, Christman BW. Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages. J. Biol. Chem [print-electronic]. 2010 Dec 12/17/2010; 285(51): 39655-62. PMID: 20937835, PMCID: PMC3000946, PII: M110.170290, DOI: 10.1074/jbc.M110.170290, ISSN: 1083-351X.

Siew ED, Ikizler TA, Gebretsadik T, Shintani A, Wickersham N, Bossert F, Peterson JF, Parikh CR, May AK, Ware LB. Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomes. Clin J Am Soc Nephrol [print-electronic]. 2010 Aug; 5(8): 1497-505. PMID: 20558561, PMCID: PMC2924408, PII: CJN.09061209, DOI: 10.2215/CJN.09061209, ISSN: 1555-905X.

Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay MA, May AK, Ware LB. Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma. 2010 May; 68(5): 1121-7. PMID: 20038857, PMCID: PMC3347639, DOI: 10.1097/TA.0b013e3181c40728, ISSN: 1529-8809.

Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT, Brower RG, Standiford TJ, Martin TR, Matthay MA, . Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest [print-electronic]. 2010 Feb; 137(2): 288-96. PMID: 19858233, PMCID: PMC2816641, PII: chest.09-1484, DOI: 10.1378/chest.09-1484, ISSN: 1931-3543.

Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA. Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio. Eur. Respir. J [print-electronic]. 2010 Feb; 35(2): 331-7. PMID: 19741024, PMCID: PMC2819058, PII: 09031936.00098709, DOI: 10.1183/09031936.00098709, ISSN: 1399-3003.

Bastarache JA, Fremont RD, Kropski JA, Bossert FR, Ware LB. Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2009 Dec; 297(6): L1035-41. PMID: 19700643, PMCID: PMC2793184, PII: 00214.2009, DOI: 10.1152/ajplung.00214.2009, ISSN: 1522-1504.

Ware LB, Eisner MD, Flaherty KR. Clinical year in review II: Sepsis, mechanical ventilation, occupational and environmental lung disease, and sleep. Proc Am Thorac Soc. 2009 Sep 9/15/2009; 6(6): 494-9. PMID: 19741256, PII: 6/6/494, DOI: 10.1513/pats.200907-060TT, ISSN: 1943-5665.

Ware LB. Clinical year in review I: Interstitial lung disease, pulmonary vascular disease, pulmonary infections, and cardiopulmonary exercise testing and pulmonary rehabilitation. Proc Am Thorac Soc. 2009 Sep 9/15/2009; 6(6): 487-93. PMID: 19741255, PII: 6/6/487, DOI: 10.1513/pats.200907-057TT, ISSN: 1943-5665.

Siew ED, Ware LB, Gebretsadik T, Shintani A, Moons KG, Wickersham N, Bossert F, Ikizler TA. Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults. J. Am. Soc. Nephrol [print-electronic]. 2009 Aug; 20(8): 1823-32. PMID: 19628673, PMCID: PMC2723988, PII: ASN.2008070673, DOI: 10.1681/ASN.2008070673, ISSN: 1533-3450.

Kropski JA, Fremont RD, Calfee CS, Ware LB. Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury. Chest [print-electronic]. 2009 Jun; 135(6): 1440-7. PMID: 19188556, PMCID: PMC2716712, PII: S0012-3692(09)60345-7, DOI: 10.1378/chest.08-2465, ISSN: 1931-3543.

Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay MA, Schopfer FJ, Baker PR, Agarwal A, Freeman BA. Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway. Free Radic. Biol. Med [print-electronic]. 2009 Apr 4/1/2009; 46(7): 866-75. PMID: 19133325, PMCID: PMC3104854, PII: S0891-5849(08)00747-8, DOI: 10.1016/j.freeradbiomed.2008.12.001, ISSN: 1873-4596.

Pandharipande PP, Shintani AK, Hagerman HE, St Jacques PJ, Rice TW, Sanders NW, Ware LB, Bernard GR, Ely EW. Derivation and validation of Spo2/Fio2 ratio to impute for Pao2/Fio2 ratio in the respiratory component of the Sequential Organ Failure Assessment score. Crit. Care Med. 2009 Apr; 37(4): 1317-21. PMID: 19242333, PMCID: PMC3776410, DOI: 10.1097/CCM.0b013e31819cefa9, ISSN: 1530-0293.

Hoffman SA, Wang L, Shah CV, Ahya VN, Pochettino A, Olthoff K, Shaked A, Wille K, Lama VN, Milstone A, Ware LB, Orens J, Weinacker A, Demissie E, Bellamy S, Kawut SM, Hancock WW, Christie JD, . Plasma cytokines and chemokines in primary graft dysfunction post-lung transplantation. Am. J. Transplant [print-electronic]. 2009 Feb; 9(2): 389-96. PMID: 19120076, PMCID: PMC2821938, PII: AJT2497, DOI: 10.1111/j.1600-6143.2008.02497.x, ISSN: 1600-6143.

Calfee CS, Eisner MD, Parsons PE, Thompson BT, Conner ER, Matthay MA, Ware LB, . Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Intensive Care Med [print-electronic]. 2009 Feb; 35(2): 248-57. PMID: 18670758, PMCID: PMC2790376, DOI: 10.1007/s00134-008-1235-0, ISSN: 1432-1238.

Ware LB, Matthay MA. Beyond fishing: the role of discovery proteomics in mechanistic lung research [editorial]. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2009 Jan; 296(1): L12-3. PMID: 19011049, PMCID: PMC2636947, PII: 90558.2008, DOI: 10.1152/ajplung.90558.2008, ISSN: 1040-0605.

Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA, . Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. Thorax [print-electronic]. 2008 Dec; 63(12): 1083-9. PMID: 18566109, PMCID: PMC2764528, PII: thx.2008.095588, DOI: 10.1136/thx.2008.095588, ISSN: 1468-3296.

Moss M, Wilkes D, Ware LB. Clinical year in review II: Pulmonary infections in the immunocompetent host, issues in the training of fellows and residents, asthma, and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2008 Sep 9/15/2008; 5(7): 745-50. PMID: 18757311, PII: 5/7/745, DOI: 10.1513/pats.200806-052TT, ISSN: 1546-3222.

Ware LB. Clinical year in review IV: Acute respiratory distress syndrome, radiology in the intensive care unit, nonpulmonary critical care, and pulmonary infections in the immunocompromised host. Proc Am Thorac Soc. 2008 Sep 9/15/2008; 5(7): 755-60. PMID: 18757313, PII: 5/7/755, DOI: 10.1513/pats.200806-049TT, ISSN: 1546-3222.

Gerszten RE, Accurso F, Bernard GR, Caprioli RM, Klee EW, Klee GG, Kullo I, Laguna TA, Roth FP, Sabatine M, Srinivas P, Wang TJ, Ware LB. Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI Clinical Proteomics Programs. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2008 Jul; 295(1): L16-22. PMID: 18456800, PMCID: PMC2494793, PII: 00044.2008, DOI: 10.1152/ajplung.00044.2008, ISSN: 1040-0605.

Lawson WE, Crossno PF, Polosukhin VV, Roldan J, Cheng DS, Lane KB, Blackwell TR, Xu C, Markin C, Ware LB, Miller GG, Loyd JE, Blackwell TS. Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2008 Jun; 294(6): L1119-26. PMID: 18390830, PII: 00382.2007, DOI: 10.1152/ajplung.00382.2007, ISSN: 1040-0605.

Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay MA, Ware LB. Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2008 May; 294(5): L874-81. PMID: 18310227, PMCID: PMC2764534, PII: 00372.2007, DOI: 10.1152/ajplung.00372.2007, ISSN: 1040-0605.

Ware LB. Modeling human lung disease in animals [editorial]. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2008 Feb; 294(2): L149-50. PMID: 18024718, PII: 00472.2007, DOI: 10.1152/ajplung.00472.2007, ISSN: 1040-0605.

Wang L, Bastarache JA, Ware LB. The coagulation cascade in sepsis. Curr. Pharm. Des. 2008; 14(19): 1860-9. PMID: 18691097, ISSN: 1873-4286.

McClintock D, Zhuo H, Wickersham N, Matthay MA, Ware LB. Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury. Crit Care [print-electronic]. 2008; 12(2): R41. PMID: 18358078, PMCID: PMC2447583, PII: cc6846, DOI: 10.1186/cc6846, ISSN: 1466-609X.

White KE, Ding Q, Moore BB, Peters-Golden M, Ware LB, Matthay MA, Olman MA. Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. J. Immunol. 2008 Jan 1/1/2008; 180(1): 637-46. PMID: 18097066, PMCID: PMC2789491, PII: 180/1/637, ISSN: 0022-1767.

Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA, . Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit. Care Med. 2007 Dec; 35(12): 2755-61. PMID: 18074478, PMCID: PMC3293249, ISSN: 0090-3493.

Girard TD, Ware LB. Biomarkers of cardiac injury in acute respiratory distress syndrome: getting to the heart of the matter [editorial]. Crit. Care Med. 2007 Nov; 35(11): 2638-9. PMID: 18075368, PII: 00003246-200711000-00025, DOI: 10.1097/01.CCM.0000288097.81989.D3, ISSN: 0090-3493.

Covarrubias M, Ware LB, Kawut SM, De Andrade J, Milstone A, Weinacker A, Orens J, Lama V, Wille K, Bellamy S, Shah C, Demissie E, Christie JD, . Plasma intercellular adhesion molecule-1 and von Willebrand factor in primary graft dysfunction after lung transplantation. Am. J. Transplant [print-electronic]. 2007 Nov; 7(11): 2573-8. PMID: 17908278, PII: AJT1981, DOI: 10.1111/j.1600-6143.2007.01981.x, ISSN: 1600-6135.

Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA, . Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit. Care Med. 2007 Oct; 35(10): 2243-50. PMID: 17944012, PMCID: PMC2765812, ISSN: 0090-3493.

Ware LB. Clinical Year in Review III: asthma, lung transplantation, cystic fibrosis, acute respiratory distress syndrome. Proc Am Thorac Soc. 2007 Sep 9/15/2007; 4(6): 489-93. PMID: 17761964, PII: 4/6/489, DOI: 10.1513/pats.200707-102TT, ISSN: 1546-3222.

Lee JW, Fang X, Dolganov G, Fremont RD, Bastarache JA, Ware LB, Matthay MA. Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells. J. Biol. Chem [print-electronic]. 2007 Aug 8/17/2007; 282(33): 24109-19. PMID: 17580309, PMCID: PMC2765119, PII: M700821200, DOI: 10.1074/jbc.M700821200, ISSN: 0021-9258.

Ware LB, Matthay MA, Parsons PE, Thompson BT, Januzzi JL, Eisner MD, . Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Crit. Care Med. 2007 Aug; 35(8): 1821-8. PMID: 17667242, PMCID: PMC2764536, PII: 00003246-200708000-00002, DOI: 10.1097/01.CCM.0000221922.08878.49, ISSN: 0090-3493.

Rice TW, Wheeler AP, Bernard GR, Hayden DL, Schoenfeld DA, Ware LB, . Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS. Chest [print-electronic]. 2007 Aug; 132(2): 410-7. PMID: 17573487, PII: chest.07-0617, DOI: 10.1378/chest.07-0617, ISSN: 0012-3692.

Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA. Genomics and proteomics of lung disease: conference summary. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2007 Jul; 293(1): L45-51. PMID: 17468134, PMCID: PMC4212816, PII: 00139.2007, DOI: 10.1152/ajplung.00139.2007, ISSN: 1040-0605.

Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay MA, Ware LB. The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax [print-electronic]. 2007 Jul; 62(7): 608-16. PMID: 17356058, PMCID: PMC2117249, PII: thx.2006.063305, DOI: 10.1136/thx.2006.063305, ISSN: 0040-6376.

Fremont RD, Kallet RH, Matthay MA, Ware LB. Postobstructive pulmonary edema: a case for hydrostatic mechanisms. Chest [print-electronic]. 2007 Jun; 131(6): 1742-6. PMID: 17413051, PMCID: PMC2783608, PII: chest.06-2934, DOI: 10.1378/chest.06-2934, ISSN: 0012-3692.

Wang L, Bastarache JA, Wickersham N, Fang X, Matthay MA, Ware LB. Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2007 Apr; 36(4): 497-503. PMID: 17099142, PMCID: PMC1899324, PII: 2005-0425OC, DOI: 10.1165/rcmb.2005-0425OC, ISSN: 1044-1549.

Flori HR, Ware LB, Milet M, Matthay MA. Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilation. Pediatr Crit Care Med. 2007 Mar; 8(2): 96-101. PMID: 17273112, PMCID: PMC3586228, DOI: 10.1097/01.PCC.0000257097.42640.6F, ISSN: 1529-7535.

McClintock DE, Ware LB, Eisner MD, Wickersham N, Thompson BT, Matthay MA, . Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury. Am. J. Respir. Crit. Care Med [print-electronic]. 2007 Feb 2/1/2007; 175(3): 256-62. PMID: 17082495, PMCID: PMC1899263, PII: 200607-947OC, DOI: 10.1164/rccm.200607-947OC, ISSN: 1073-449X.

Christie JD, Robinson N, Ware LB, Plotnick M, De Andrade J, Lama V, Milstone A, Orens J, Weinacker A, Demissie E, Bellamy S, Kawut SM. Association of protein C and type 1 plasminogen activator inhibitor with primary graft dysfunction. Am. J. Respir. Crit. Care Med [print-electronic]. 2007 Jan 1/1/2007; 175(1): 69-74. PMID: 17023732, PMCID: PMC1899260, PII: 200606-827OC, DOI: 10.1164/rccm.200606-827OC, ISSN: 1073-449X.

Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat. Med [print-electronic]. 2006 Nov; 12(11): 1286-93. PMID: 17086189, PMCID: PMC2768268, PII: nm1494, DOI: 10.1038/nm1494, ISSN: 1078-8956.

Wardwell NR, Miller R, Ware LB. Pulmonary alveolar proteinosis associated with a disease-modifying antirheumatoid arthritis drug. Respirology. 2006 Sep; 11(5): 663-5. PMID: 16916345, PII: RES905, DOI: 10.1111/j.1440-1843.2006.00905.x, ISSN: 1323-7799.

Sapru A, Wiemels JL, Witte JS, Ware LB, Matthay MA. Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways. Intensive Care Med [print-electronic]. 2006 Sep; 32(9): 1293-303. PMID: 16770611, DOI: 10.1007/s00134-006-0223-5, ISSN: 0342-4642.

Ganter MT, Ware LB, Howard M, Roux J, Gartland B, Matthay MA, Fleshner M, Pittet JF. Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2006 Sep; 291(3): L354-61. PMID: 16679378, PMCID: PMC2765126, PII: 00405.2005, DOI: 10.1152/ajplung.00405.2005, ISSN: 1040-0605.

Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA. Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2006 Sep; 291(3): L307-11. PMID: 16648240, PII: 00157.2006, DOI: 10.1152/ajplung.00157.2006, ISSN: 1040-0605.

Bastarache JA, Ware LB, Bernard GR. The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome. Semin Respir Crit Care Med. 2006 Aug; 27(4): 365-76. PMID: 16909370, DOI: 10.1055/s-2006-948290, ISSN: 1069-3424.

Ware LB. Pathophysiology of acute lung injury and the acute respiratory distress syndrome. Semin Respir Crit Care Med. 2006 Aug; 27(4): 337-49. PMID: 16909368, DOI: 10.1055/s-2006-948288, ISSN: 1069-3424.

Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K, Mednick G, Matthay ZA, Matthay MA. Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am. J. Respir. Crit. Care Med [print-electronic]. 2006 May 5/1/2006; 173(9): 1008-15. PMID: 16456142, PMCID: PMC2662912, PII: 200509-1477OC, DOI: 10.1164/rccm.200509-1477OC, ISSN: 1073-449X.

Matthay MA, Christman JW, Pitt BR, Schwiebert LM, Stevens T, Ware LB. Perspectives, translational research, and letters to the editor [editorial]. Am. J. Physiol. Lung Cell Mol. Physiol. 2006 Apr; 290(4): L621. PMID: 16531563, PII: 290/4/L621, DOI: 10.1152/ajplung.00003.2006, ISSN: 1040-0605.

Sakuma T, Gu X, Wang Z, Maeda S, Sugita M, Sagawa M, Osanai K, Toga H, Ware LB, Folkesson G, Matthay MA. Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine. Crit. Care Med. 2006 Mar; 34(3): 676-81. PMID: 16505652, PMCID: PMC2765117, PII: 00003246-200603000-00014, DOI: 10.1097/01.CCM.0000201403.70636.0F, ISSN: 0090-3493.

Ware LB, Matthay MA. Clinical practice. Acute pulmonary edema. N. Engl. J. Med. 2005 Dec 12/29/2005; 353(26): 2788-96. PMID: 16382065, PII: 353/26/2788, DOI: 10.1056/NEJMcp052699, ISSN: 1533-4406.

Ware LB, Fang X, Wang Y, Babcock WD, Jones K, Matthay MA. High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation. J. Heart Lung Transplant. 2005 Oct; 24(10): 1650-6. PMID: 16210143, PII: S1053-2498(04)00614-X, DOI: 10.1016/j.healun.2004.11.011, ISSN: 1557-3117.

Arcasoy SM, Fisher A, Hachem RR, Scavuzzo M, Ware LB, . Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part V: predictors and outcomes. J. Heart Lung Transplant. 2005 Oct; 24(10): 1483-8. PMID: 16210119, PII: S1053-2498(04)01052-6, DOI: 10.1016/j.healun.2004.11.314, ISSN: 1557-3117.

Ware LB, Bastarache JA, Wang L. Coagulation and fibrinolysis in human acute lung injury--new therapeutic targets?. Keio J Med. 2005 Sep; 54(3): 142-9. PMID: 16237276, ISSN: 0022-9717.

Ware LB, Kaner RJ, Crystal RG, Schane R, Trivedi NN, McAuley D, Matthay MA. VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema. Eur. Respir. J. 2005 Jul; 26(1): 101-5. PMID: 15994395, PMCID: PMC2757043, PII: 26/1/101, DOI: 10.1183/09031936.05.00106604, ISSN: 0903-1936.

Fussell KM, Awad JA, Ware LB. Case of fulminant hepatic failure due to unrecognized peripartum cardiomyopathy. Crit. Care Med. 2005 Apr; 33(4): 891-3. PMID: 15818120, PII: 00003246-200504000-00029, ISSN: 0090-3493.

Ware LB. Prognostic determinants of acute respiratory distress syndrome in adults: impact on clinical trial design. Crit. Care Med. 2005 Mar; 33(3 Suppl): S217-22. PMID: 15753731, PII: 00003246-200503001-00017, ISSN: 0090-3493.

Parsons PE, Matthay MA, Ware LB, Eisner MD, . Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2005 Mar; 288(3): L426-31. PMID: 15516488, PII: 00302.2004, DOI: 10.1152/ajplung.00302.2004, ISSN: 1040-0605.

Cheng IW, Eisner MD, Thompson BT, Ware LB, Matthay MA, . Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury. Crit. Care Med. 2005 Jan; 33(1): 63-70; discussion 239. PMID: 15644650, PII: 00003246-200501000-00010, ISSN: 0090-3493.

Nathens AB, Curtis JR, Beale RJ, Cook DJ, Moreno RP, Romand JA, Skerrett SJ, Stapleton RD, Ware LB, Waldmann CS. Management of the critically ill patient with severe acute pancreatitis. Crit. Care Med. 2004 Dec; 32(12): 2524-36. PMID: 15599161, PII: 00003246-200412000-00024, ISSN: 0090-3493.

Ware LB. Keratinocyte growth factor as an epithelial protective agent: where do we stand? [editorial]. Int. J. Radiat. Oncol. Biol. Phys. 2004 Dec 12/1/2004; 60(5): 1345-6. PMID: 15590162, PII: S0360-3016(04)02574-X, DOI: 10.1016/j.ijrobp.2004.09.015, ISSN: 0360-3016.

Matthay MA, Ware LB. Can nicotine treat sepsis?. Nature medicine. 2004 Nov; 10(11) Sect. 1161,2.

Sue RD, Matthay MA, Ware LB. Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edema. Intensive Care Med [print-electronic]. 2004 Oct; 30(10): 1921-6. PMID: 15258730, DOI: 10.1007/s00134-004-2379-1, ISSN: 0342-4642.

Ware LB, Eisner MD, Thompson BT, Parsons PE, Matthay MA. Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury. Am. J. Respir. Crit. Care Med [print-electronic]. 2004 Oct 10/1/2004; 170(7): 766-72. PMID: 15201135, PII: 200310-1434OC, DOI: 10.1164/rccm.200310-1434OC, ISSN: 1073-449X.

Bowler RP, Duda B, Chan ED, Enghild JJ, Ware LB, Matthay MA, Duncan MW. Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2004 Jun; 286(6): L1095-104. PMID: 14742308, PII: 00304.2003, DOI: 10.1152/ajplung.00304.2003, ISSN: 1040-0605.

Matthay MA, Ware LB. Plasma protein C levels in patients with acute lung injury: prognostic significance. Crit. Care Med. 2004 May; 32(5 Suppl): S229-32. PMID: 15118523, PII: 00003246-200405001-00008, ISSN: 0090-3493.

Olman MA, White KE, Ware LB, Simmons WL, Benveniste EN, Zhu S, Pugin J, Matthay MA. Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression. J. Immunol. 2004 Feb 2/15/2004; 172(4): 2668-77. PMID: 14764742, ISSN: 0022-1767.

Ware LB. Modulation of alveolar fluid clearance by acute inflammation: the plot thickens [editorial]. Am. J. Respir. Crit. Care Med. 2004 Feb 2/1/2004; 169(3): 332-3. PMID: 14739132, PII: 169/3/332, DOI: 10.1164/rccm.2311006, ISSN: 1073-449X.

Wang L, Zhu DM, Su X, Bai CX, Ware LB, Matthay MA. Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs. Exp. Lung Res. 2004 Jan; 30(1): 31-42. PMID: 14967602, PII: A060FTV17639978D, ISSN: 0190-2148.

Nathens AB, Curtis JR, Beale RJ, Cook DJ, Moreno RP, Romand JA, Skerrett SJ, Stapleton RD, Ware LB, Waldmann CS. Executive summary: management of the critically ill patient with severe acute pancreatitis. Proc Am Thorac Soc. 2004; 1(4): 289-90. PMID: 16113448, PII: 1/4/289, DOI: 10.1513/pats.200406-820ST, ISSN: 1546-3222.

Eisner MD, Parsons P, Matthay MA, Ware L, Greene K, . Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Thorax. 2003 Nov; 58(11): 983-8. PMID: 14586055, PMCID: PMC1746524, ISSN: 0040-6376.

Bowler RP, Velsor LW, Duda B, Chan ED, Abraham E, Ware LB, Matthay MA, Day BJ. Pulmonary edema fluid antioxidants are depressed in acute lung injury. Crit. Care Med. 2003 Sep; 31(9): 2309-15. PMID: 14501961, DOI: 10.1097/01.CCM.0000085090.06078.8C, ISSN: 0090-3493.

Ware LB, Fang X, Matthay MA. Protein C and thrombomodulin in human acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2003 Sep; 285(3): L514-21. PMID: 12754194, PII: 00442.2002, DOI: 10.1152/ajplung.00442.2002, ISSN: 1040-0605.

Flori HR, Ware LB, Glidden D, Matthay MA. Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation. Pediatr Crit Care Med. 2003 Jul; 4(3): 315-21. PMID: 12831413, PII: 01.PCC.0000074583.27727.8E, DOI: 10.1097/01.PCC.0000074583.27727.8E, ISSN: 1529-7535.

Prabhakaran P, Ware LB, White KE, Cross MT, Matthay MA, Olman MA. Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2003 Jul; 285(1): L20-8. PMID: 12730079, PII: 00312.2002, DOI: 10.1152/ajplung.00312.2002, ISSN: 1040-0605.

Galiacy S, Planus E, Lepetit H, Féréol S, Laurent V, Ware L, Isabey D, Matthay M, Harf A, d'Ortho MP. Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro. Exp. Cell Res. 2003 Feb 2/15/2003; 283(2): 215-29. PMID: 12581741, PII: S0014482702000496, ISSN: 0014-4827.

Cheng IW, Ware LB, Greene KE, Nuckton TJ, Eisner MD, Matthay MA. Prognostic value of surfactant proteins A and D in patients with acute lung injury. Crit. Care Med. 2003 Jan; 31(1): 20-7. PMID: 12544988, DOI: 10.1097/01.CCM.0000045028.46623.C2, ISSN: 0090-3493.

Albertine KH, Soulier MF, Wang Z, Ishizaka A, Hashimoto S, Zimmerman GA, Matthay MA, Ware LB. Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am. J. Pathol. 2002 Nov; 161(5): 1783-96. PMID: 12414525, PMCID: PMC1850801, PII: S0002-9440(10)64455-0, DOI: 10.1016/S0002-9440(10)64455-0, ISSN: 0002-9440.

Ware LB, Fang X, Wang Y, Sakuma T, Hall TS, Matthay MA. Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung. J. Appl. Physiol. 2002 Nov; 93(5): 1869-74. PMID: 12381777, DOI: 10.1152/japplphysiol.00252.2002, ISSN: 8750-7587.

Pham I, Uchida T, Planes C, Ware LB, Kaner R, Matthay MA, Clerici C. Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo. Am. J. Physiol. Lung Cell Mol. Physiol. 2002 Nov; 283(5): L1133-42. PMID: 12376368, DOI: 10.1152/ajplung.00464.2001, ISSN: 1040-0605.

Ware LB, Matthay MA. Measuring microvascular blood flow in sepsis--a continuing challenge. Lancet. 2002 Oct 10/19/2002; 360(9341): 1187-8. PMID: 12401242, PII: S0140-6736(02)11292-X, DOI: 10.1016/S0140-6736(02)11292-X, ISSN: 0140-6736.

Matthay MA, Bhattacharya S, Gaver D, Ware LB, Lim LH, Syrkina O, Eyal F, Hubmayr R. Ventilator-induced lung injury: in vivo and in vitro mechanisms. Am. J. Physiol. Lung Cell Mol. Physiol. 2002 Oct; 283(4): L678-82. PMID: 12225942, DOI: 10.1152/ajplung.00154.2002, ISSN: 1040-0605.

Ware LB, Wang Y, Fang X, Warnock M, Sakuma T, Hall TS, Matthay M. Assessment of lungs rejected for transplantation and implications for donor selection. Lancet. 2002 Aug 8/24/2002; 360(9333): 619-20. PMID: 12241936, PII: S014067360209774X, ISSN: 0140-6736.

Atabai K, Ishigaki M, Geiser T, Ueki I, Matthay MA, Ware LB. Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms. Am. J. Physiol. Lung Cell Mol. Physiol. 2002 Jul; 283(1): L163-9. PMID: 12060573, DOI: 10.1152/ajplung.00396.2001, ISSN: 1040-0605.

Atabai K, Ware LB, Snider ME, Koch P, Daniel B, Nuckton TJ, Matthay MA. Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure. Intensive Care Med [print-electronic]. 2002 Jun; 28(6): 705-11. PMID: 12107675, DOI: 10.1007/s00134-002-1282-x, ISSN: 0342-4642.

Ware LB, Matthay MA. Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. Am. J. Physiol. Lung Cell Mol. Physiol. 2002 May; 282(5): L924-40. PMID: 11943656, DOI: 10.1152/ajplung.00439.2001, ISSN: 1040-0605.

Olman MA, White KE, Ware LB, Cross MT, Zhu S, Matthay MA. Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1. Chest. 2002 Mar; 121(3 Suppl): 69S-70S. PMID: 11893691, ISSN: 0012-3692.

Ware LB, Conner ER, Matthay MA. Von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury. Crit. Care Med. 2001 Dec; 29(12): 2325-31. PMID: 11801836, ISSN: 0090-3493.

Brower RG, Ware LB, Berthiaume Y, Matthay MA. Treatment of ARDS. Chest. 2001 Oct; 120(4): 1347-67. PMID: 11591581, ISSN: 0012-3692.

Geiser T, Atabai K, Jarreau PH, Ware LB, Pugin J, Matthay MA. Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism. Am. J. Respir. Crit. Care Med. 2001 May; 163(6): 1384-8. PMID: 11371405, DOI: 10.1164/ajrccm.163.6.2006131, ISSN: 1073-449X.

Ware LB, Matthay MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 2001 May; 163(6): 1376-83. PMID: 11371404, DOI: 10.1164/ajrccm.163.6.2004035, ISSN: 1073-449X.

Zhu S, Ware LB, Geiser T, Matthay MA, Matalon S. Increased levels of nitrate and surfactant protein a nitration in the pulmonary edema fluid of patients with acute lung injury. Am. J. Respir. Crit. Care Med. 2001 Jan; 163(1): 166-72. PMID: 11208643, DOI: 10.1164/ajrccm.163.1.2005068, ISSN: 1073-449X.

Ware LB, Matthay MA. The acute respiratory distress syndrome. N. Engl. J. Med. 2000 May 5/4/2000; 342(18): 1334-49. PMID: 10793167, DOI: 10.1056/NEJM200005043421806, ISSN: 0028-4793.

Wang Y, Folkesson HG, Jayr C, Ware LB, Matthay MA. Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta-agonist therapy. J. Appl. Physiol. 1999 Nov; 87(5): 1852-60. PMID: 10562630, ISSN: 8750-7587.

Verghese GM, Ware LB, Matthay BA, Matthay MA. Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema. J. Appl. Physiol. 1999 Oct; 87(4): 1301-12. PMID: 10517756, ISSN: 8750-7587.

Ware LB, Golden JA, Finkbeiner WE, Matthay MA. Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation. Am. J. Respir. Crit. Care Med. 1999 Mar; 159(3): 980-8. PMID: 10051282, DOI: 10.1164/ajrccm.159.3.9802105, ISSN: 1073-449X.

Ware LB, Keith FM, Gordon RL, Ries CA, Seitz RF, Gold WM, Golden JA. Lung transplantation for pulmonary amyloidosis: a case report. J. Heart Lung Transplant. 1998 Nov; 17(11): 1129-32. PMID: 9855453, ISSN: 1053-2498.

Matthay MA, Flori HR, Conner ER, Ware LB. Alveolar epithelial fluid transport: basic mechanisms and clinical relevance. Proc. Assoc. Am. Physicians. 1998 Nov; 110(6): 496-505. PMID: 9824532, ISSN: 1081-650X.

Available Postdoctoral Position Details
Posted: 8/15/2017

Description of Position

A postdoctoral position is immediately available in the laboratories of Dr. Lorraine Ware, Professor of Medicine and Pathology, Microbioloby and Immunology and Dr. Julie Bastarache, Department of Medicine at Vanderbilt University School of Medicine. Our translational research group studies pathogenic mechanisms of sepsis and acute lung injury with a specific focus on mechanisms of lung epithelial and endothelial injury. A major focus is on understanding the cellular and molecular mechanisms of cell-free hemoglobin-mediated lung epithelial and microvascular endothelial permeability. This postdoctoral fellowship will afford the fellow the opportunity to drive this project forward using a multitude of tools and models available in our group including primary and immortalized cell culture, multiple genetically modifed mouse lines, mouse models of acute lung injury and sepsis as well as the ex vivo perfused human lung.

Qualifications for the Position

Candidates must have an MD and/or PhD in a related medical or biological sciences field. Successful candidates should be self-starters and highly motivated to thrive in a rich research environment. Expertise with cell culture and mouse studies is required. Specific expertise in mitochondrial biology, apoptosis, and/or redox biology would be helpful but is not required. The successful candidate should have a demonstrated ability to work both independently and collaboratively, possess strong oral and written communication skills and have a strong foundation in bench science. Responsibilities include designing and implementing experiments, data collection and review, abstract and manuscript preparation and local and national scientific presentations. A successful fellow will leave the program with a broad knowledge of acute lung injury and sepsis, a robust scientific skillset, expertise in a wide range of laboratory techniques and an opportunity for presentation and publication. Questions about the position can be directed to Lorraine.ware@vanderbilt.edu or Julie.bastarache@vanderbilt.edu.