BethAnn McLaughlin, Ph.D.

Assistant Professor

bethann.mclaughlin@vanderbilt.edu

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Faculty Appointments
Assistant Professor of Neurology Assistant Professor of PharmacologyAssistant Professor of Pharmacology
Education
Ph.D., NEUROSCIENCES, University of Pennsylvania, Philadelphia, PennsylvaniaB.A., Skidmore College , Saratoga Springs, New York
Office Address
8110 MRB III
465 21st Avenue South
Nashville, TN 37232-8548
Research Description
My laboratory is interested in studying cell signaling pathways related to neurodegeneration and protection. We have developed several in vivo and in vitro systems in which cortical neuronal cells can be rendered less sensitive to cell death following a nontoxic exposure to mild stressors. We use a variety of biochemical, molecular and proteomic approaches to both enhance our understanding of signaling pathways that we have already determined to be critical for the expression of preconditioning as well as to identify new protein targets which may contribute to this phenomenon. Our findings suggest that intervention against neurological events which result in subtoxic activation of traditional cell death pathways may actually increase vulnerability to subsequent stressors.
Other ongoing lab projects include understanding how classical biochemical changes in ion homeostasis and energetics induce the molecular pathways associated with apoptotic and autophaghic neuronal death.
Ongoing projects in the lab support mechanistic studies of mediators of apoptosis signaling kinase, chaperone proteins and mitochondrial dynamics.
The goal of my research program is to understand the endogenous pathways associated with neurodegeneration and protection to develop novel therapeutics for stroke, cerebral palsy and other degenerative conditions. In addition, these studies investigate signaling pathways which provide protective mechanisms against other forms of cell death.
Research Keywords
Neurodegeneration, Stroke, Parkinsons disease, Cell signaling, Mitochondria, Drug Discovery, Cell biology
Clinical Research Keywords
Stroke, transient ischemic attack, neurodegeneration, Parkinsons disease, Alzheimer's disease, cerebral palsy, head injury
Publications
Federspiel JD, Codreanu SG, Palubinsky AM, Winland AJ, Morales Betanzos C, McLaughlin B, Liebler DC. Assembly dynamics and stoichiometry of the apoptosis signal-regulating kinase (ASK) signalosome in response to electrophile stress. Mol. Cell Proteomics [print-electronic]. 2016 Mar 3/22/2016; PMID: 27006476, PII: M115.057364, DOI: 10.1074/mcp.M115.057364, ISSN: 1535-9484.

Khan IS, Odom M, Ehtesham M, Colvin D, Quarles CC, McLaughlin B, Singer RJ. Intraarterial administration of norcantharidin attenuates ischemic stroke damage in rodents when given at the time of reperfusion: novel uses of endovascular capabilities. J. Neurosurg [print-electronic]. 2015 Nov 11/6/2015; 1-8. PMID: 26544777, DOI: 10.3171/2015.4.JNS142400, ISSN: 1933-0693.

Palubinsky AM, Stankowski JN, Kale AC, Codreanu SG, Singer RJ, Liebler DC, Stanwood GD, McLaughlin B. CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling. Antioxid. Redox Signal [print-electronic]. 2015 Aug 8/20/2015; 23(6): 535-49. PMID: 25602369, PMCID: PMC4544748, DOI: 10.1089/ars.2014.6102, ISSN: 1557-7716.

Grelli KN, Palubinsky AM, Kale AC, Lizama-Manibusan BN, Stankowski JN, Milne GL, Singer R, McLaughlin B. Alteration of isocitrate dehydrogenase following acute ischemic injury as a means to improve cellular energetic status in neuroadaptation. CNS Neurol Disord Drug Targets. 2013 Sep; 12(6): 849-60. PMID: 23469839, PMCID: PMC3770751, PII: CDTCNSND-EPUB-20130227-4, ISSN: 1996-3181.

Lizama-Manibusan B, McLaughlin B. Redox modification of proteins as essential mediators of CNS autophagy and mitophagy. FEBS Lett [print-electronic]. 2013 Aug 8/2/2013; 587(15): 2291-8. PMID: 23773928, PII: S0014-5793(13)00452-3, DOI: 10.1016/j.febslet.2013.06.007, ISSN: 1873-3468.

Ice RJ, McLaughlin SL, Livengood RH, Culp MV, Eddy ER, Ivanov AV, Pugacheva EN. NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors. Cancer Res [print-electronic]. 2013 May 5/15/2013; 73(10): 3168-80. PMID: 23539442, PMCID: PMC3667743, PII: 0008-5472.CAN-12-4008, DOI: 10.1158/0008-5472.CAN-12-4008, ISSN: 1538-7445.

McLaughlin B, Gidday JM. Poised for success: implementation of sound conditioning strategies to promote endogenous protective responses to stroke in patients. Transl Stroke Res [print-electronic]. 2013 Feb; 4(1): 104-13. PMID: 24323191, PMCID: PMC4227500, DOI: 10.1007/s12975-012-0240-3, ISSN: 1868-601X.

Gorrindo P, Lane CJ, Lee EB, McLaughlin B, Levitt P. Enrichment of elevated plasma F2t-isoprostane levels in individuals with autism who are stratified by presence of gastrointestinal dysfunction. PLoS ONE [electronic-print]. 2013; 8(7): e68444. PMID: 23844202, PMCID: PMC3700867, PII: PONE-D-13-09401, DOI: 10.1371/journal.pone.0068444, ISSN: 1932-6203.

Alcendor DJ, Block FE, Cliffel DE, Daniels JS, Ellacott KL, Goodwin CR, Hofmeister LH, Li D, Markov DA, May JC, McCawley LJ, McLaughlin B, McLean JA, Niswender KD, Pensabene V, Seale KT, Sherrod SD, Sung HJ, Tabb DL, Webb DJ, Wikswo JP. Neurovascular unit on a chip: implications for translational applications. Stem Cell Res Ther [print-electronic]. 2013; 4 Suppl 1: S18. PMID: 24564885, PMCID: PMC4029462, PII: scrt379, DOI: 10.1186/scrt379, ISSN: 1757-6512.

Kerr E, Holohan C, McLaughlin KM, Majkut J, Dolan S, Redmond K, Riley J, McLaughlin K, Stasik I, Crudden M, Van Schaeybroeck S, Fenning C, O'Connor R, Kiely P, Sgobba M, Haigh D, Johnston PG, Longley DB. Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis. Cell Death Differ [print-electronic]. 2012 Aug; 19(8): 1317-27. PMID: 22322857, PMCID: PMC3392639, PII: cdd20128, DOI: 10.1038/cdd.2012.8, ISSN: 1476-5403.

McKenzie JR, Palubinsky AM, Brown JE, McLaughlin B, Cliffel DE. Metabolic multianalyte microphysiometry reveals extracellular acidosis is an essential mediator of neuronal preconditioning. ACS Chem Neurosci [print-electronic]. 2012 Jul 7/18/2012; 3(7): 510-8. PMID: 22860220, PMCID: PMC3399578, DOI: 10.1021/cn300003r, ISSN: 1948-7193.

Albers E, Donahue BS, Milne G, Saville BR, Wang W, Bichell D, McLaughlin B. Perioperative plasma F(2)-Isoprostane levels correlate with markers of impaired ventilation in infants with single-ventricle physiology undergoing stage 2 surgical palliation on the cardiopulmonary bypass. Pediatr Cardiol [print-electronic]. 2012 Apr; 33(4): 562-8. PMID: 22327227, PMCID: PMC3641818, DOI: 10.1007/s00246-012-0166-2, ISSN: 1432-1971.

McLaughlin B, Buendia MA, Saborido TP, Palubinsky AM, Stankowski JN, Stanwood GD. Haploinsufficiency of the E3 ubiquitin ligase C-terminus of heat shock cognate 70 interacting protein (CHIP) produces specific behavioral impairments. PLoS ONE [print-electronic]. 2012; 7(5): e36340. PMID: 22606257, PMCID: PMC3350526, PII: PONE-D-12-06216, DOI: 10.1371/journal.pone.0036340, ISSN: 1932-6203.

Palubinsky AM, Martin JA, McLaughlin B. The role of central nervous system development in late-onset neurodegenerative disorders. Dev. Neurosci [print-electronic]. 2012; 34(2-3): 129-39. PMID: 22572535, PII: 000336828, DOI: 10.1159/000336828, ISSN: 1421-9859.

Brooks JD, Musiek ES, Koestner TR, Stankowski JN, Howard JR, Brunoldi EM, Porta A, Zanoni G, Vidari G, Morrow JD, Milne GL, McLaughlin B. The fatty acid oxidation product 15-A3t-isoprostane is a potent inhibitor of NF¿B transcription and macrophage transformation. J. Neurochem [print-electronic]. 2011 Nov; 119(3): 604-16. PMID: 21838782, PMCID: PMC3640263, DOI: 10.1111/j.1471-4159.2011.07422.x, ISSN: 1471-4159.

Redgrove KA, Anderson AL, Dun MD, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B. Involvement of multimeric protein complexes in mediating the capacitation-dependent binding of human spermatozoa to homologous zonae pellucidae. Dev. Biol [print-electronic]. 2011 Aug 8/15/2011; 356(2): 460-74. PMID: 21672535, PII: S0012-1606(11)00989-4, DOI: 10.1016/j.ydbio.2011.05.674, ISSN: 1095-564X.

Stankowski JN, Zeiger SL, Cohen EL, DeFranco DB, Cai J, McLaughlin B. C-terminus of heat shock cognate 70 interacting protein increases following stroke and impairs survival against acute oxidative stress. Antioxid. Redox Signal [print-electronic]. 2011 May 5/15/2011; 14(10): 1787-801. PMID: 20677910, PMCID: PMC3078511, DOI: 10.1089/ars.2010.3300, ISSN: 1557-7716.

Zeiger SL, Stankowski JN, McLaughlin B. Assessing neuronal bioenergetic status. Methods Mol. Biol. 2011; 758: 215-35. PMID: 21815069, PMCID: PMC3678904, DOI: 10.1007/978-1-61779-170-3_15, ISSN: 1940-6029.

Zeiger SL, McKenzie JR, Stankowski JN, Martin JA, Cliffel DE, McLaughlin B. Neuron specific metabolic adaptations following multi-day exposures to oxygen glucose deprivation. Biochim. Biophys. Acta [print-electronic]. 2010 Nov; 1802(11): 1095-104. PMID: 20656023, PMCID: PMC2943006, PII: S0925-4439(10)00150-X, DOI: 10.1016/j.bbadis.2010.07.013, ISSN: 0006-3002.

Karim SA, Barrie JA, McCulloch MC, Montague P, Edgar JM, Iden DL, Anderson TJ, Nave KA, Griffiths IR, McLaughlin M. PLP/DM20 expression and turnover in a transgenic mouse model of Pelizaeus-Merzbacher disease. Glia. 2010 Nov 11/1/2010; 58(14): 1727-38. PMID: 20629189, DOI: 10.1002/glia.21043, ISSN: 1098-1136.

Kleman AM, Brown JE, Zeiger SL, Hettinger JC, Brooks JD, Holt B, Morrow JD, Musiek ES, Milne GL, McLaughlin B. P66(shc)'s role as an essential mitophagic molecule in controlling neuronal redox and energetic tone. Autophagy [print-electronic]. 2010 Oct; 6(7): 948-9. PMID: 20724835, PMCID: PMC3679093, PII: 13007, DOI: 10.1523/j.neurosci.6366-09.2010, ISSN: 1554-8635.

Albers EL, Bichell DP, McLaughlin B. New approaches to neuroprotection in infant heart surgery. Pediatr. Res. 2010 Jul; 68(1): 1-9. PMID: 20351657, PMCID: PMC2921700, DOI: 10.1203/PDR.0b013e3181df5402, ISSN: 1530-0447.

Brown JE, Zeiger SL, Hettinger JC, Brooks JD, Holt B, Morrow JD, Musiek ES, Milne G, McLaughlin B. Essential role of the redox-sensitive kinase p66shc in determining energetic and oxidative status and cell fate in neuronal preconditioning. J. Neurosci. 2010 Apr 4/14/2010; 30(15): 5242-52. PMID: 20392947, PMCID: PMC2869196, PII: 30/15/5242, DOI: 10.1523/JNEUROSCI.6366-09.2010, ISSN: 1529-2401.

Yang F, Cheng Y, An JY, Kwon YT, Eckardt S, Leu NA, McLaughlin KJ, Wang PJ. The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis. PLoS ONE. 2010; 5(11): e14017. PMID: 21103378, PMCID: PMC2982839, DOI: 10.1371/journal.pone.0014017, ISSN: 1932-6203.

Zeiger SL, Musiek ES, Zanoni G, Vidari G, Morrow JD, Milne GJ, McLaughlin B. Neurotoxic lipid peroxidation species formed by ischemic stroke increase injury. Free Radic. Biol. Med [print-electronic]. 2009 Nov 11/15/2009; 47(10): 1422-31. PMID: 19699297, PMCID: PMC2767385, PII: S0891-5849(09)00496-1, DOI: 10.1016/j.freeradbiomed.2009.08.011, ISSN: 1873-4596.

Kawanami D, Mahabeleshwar GH, Lin Z, Atkins GB, Hamik A, Haldar SM, Maemura K, Lamanna JC, Jain MK. Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium. J. Biol. Chem [print-electronic]. 2009 Jul 7/31/2009; 284(31): 20522-30. PMID: 19491109, PMCID: PMC2742816, PII: M109.025346, DOI: 10.1074/jbc.M109.025346, ISSN: 1083-351X.

Stanwood GD, Leitch DB, Savchenko V, Wu J, Fitsanakis VA, Anderson DJ, Stankowski JN, Aschner M, McLaughlin B. Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia. J. Neurochem [print-electronic]. 2009 Jul; 110(1): 378-89. PMID: 19457100, PMCID: PMC2737271, PII: JNC6145, DOI: 10.1111/j.1471-4159.2009.06145.x, ISSN: 1471-4159.

Kazi A, Lawrence H, Guida WC, McLaughlin ML, Springett GM, Berndt N, Yip RM, Sebti SM. Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells. Cell Cycle [print-electronic]. 2009 Jun 6/15/2009; 8(12): 1940-51. PMID: 19471122, PMCID: PMC2892826, PII: 8798, ISSN: 1551-4005.

Musiek ES, Brooks JD, Joo M, Brunoldi E, Porta A, Zanoni G, Vidari G, Blackwell TS, Montine TJ, Milne GL, McLaughlin B, Morrow JD. Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. J. Biol. Chem [print-electronic]. 2008 Jul 7/18/2008; 283(29): 19927-35. PMID: 18490445, PMCID: PMC2459280, PII: M803625200, DOI: 10.1074/jbc.M803625200, ISSN: 0021-9258.

Cohen SJ, Engstrom PF, Lewis NL, Langer CJ, McLaughlin S, Beard M, Weiner LM, Meropol NJ. Phase I study of capecitabine and oxaliplatin in combination with the proteasome inhibitor bortezomib in patients with advanced solid tumors. Am. J. Clin. Oncol. 2008 Feb; 31(1): 1-5. PMID: 18376220, PII: 00000421-200802000-00001, DOI: 10.1097/COC.0b013e31805c142f, ISSN: 1537-453X.

McLaughlin, B.A. and Kirschner, H.. Wagging the dog-moving closer to features defined by basic scientists, the protection of prodromal transient ischaemic attacks reveals itself (p 755-756). European Journal of Neurology. 2008; 8((15)): 755-6.

Jiang GC, Tidwell K, McLaughlin BA, Cai J, Gupta RC, Milatovic D, Nass R, Aschner M. Neurotoxic potential of depleted uranium effects in primary cortical neuron cultures and in Caenorhabditis elegans. Toxicol. Sci [print-electronic]. 2007 Oct; 99(2): 553-65. PMID: 17636247, PII: kfm171, DOI: 10.1093/toxsci/kfm171, ISSN: 1096-6080.

Altay T, McLaughlin B, Wu JY, Park TS, Gidday JM. Slit modulates cerebrovascular inflammation and mediates neuroprotection against global cerebral ischemia. Exp. Neurol [print-electronic]. 2007 Oct; 207(2): 186-94. PMID: 17714707, PMCID: PMC2227314, PII: S0014-4886(07)00240-3, DOI: 10.1016/j.expneurol.2007.06.028, ISSN: 0014-4886.

Musiek ES, McLaughlin B, Morrow JD. Electrophilic cyclopentenone isoprostanes in neurodegeneration. J. Mol. Neurosci. 2007 Sep; 33(1): 80-6. PMID: 17901550, PMCID: PMC2881560, PII: JMN:33:1:80, ISSN: 0895-8696.

O'Duffy AE, Bordelon YM, McLaughlin B. Killer proteases and little strokes--how the things that do not kill you make you stronger. J. Cereb. Blood Flow Metab [print-electronic]. 2007 Apr; 27(4): 655-68. PMID: 16896349, PMCID: PMC2881558, PII: 9600380, DOI: 10.1038/sj.jcbfm.9600380, ISSN: 0271-678X.

McLaughlin M, Karim SA, Montague P, Barrie JA, Kirkham D, Griffiths IR, Edgar JM. Genetic background influences UPR but not PLP processing in the rumpshaker model of PMD/SPG2. Neurochem. Res [print-electronic]. 2007 Feb; 32(2): 167-76. PMID: 16944321, DOI: 10.1007/s11064-006-9122-y, ISSN: 0364-3190.

Hoopfer ED, McLaughlin T, Watts RJ, Schuldiner O, O'Leary DD, Luo L. Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning. Neuron. 2006 Jun 6/15/2006; 50(6): 883-95. PMID: 16772170, PII: S0896-6273(06)00380-1, DOI: 10.1016/j.neuron.2006.05.013, ISSN: 0896-6273.

Musiek ES, Breeding RS, Milne GL, Zanoni G, Morrow JD, McLaughlin B. Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration. J. Neurochem [print-electronic]. 2006 Jun; 97(5): 1301-13. PMID: 16638022, PMCID: PMC2881557, PII: JNC3797, DOI: 10.1111/j.1471-4159.2006.03797.x, ISSN: 0022-3042.

McLaughlin M, Barrie JA, Karim S, Montague P, Edgar JM, Kirkham D, Thomson CE, Griffiths IR. Processing of PLP in a model of Pelizaeus-Merzbacher disease/SPG2 due to the rumpshaker mutation. Glia. 2006 May; 53(7): 715-22. PMID: 16506223, DOI: 10.1002/glia.20325, ISSN: 0894-1491.

Milne, G. L., Musiek, E. S., Zanoni, G., Vidari, G., McLaughlin, B., Morrow, J. D. Development of a novel liquid chromatography-mass spectrometric assay to measure formation of highly reactive cyclopentenone isoprostanes in vivo. Clinical Pharmacology & Therapeutics. 2006; 79: 36.

Di Napoli M, McLaughlin B. The ubiquitin-proteasome system as a drug target in cerebrovascular disease: therapeutic potential of proteasome inhibitors. Curr Opin Investig Drugs. 2005 Jul; 6(7): 686-99. PMID: 16044664, PMCID: PMC2880390, ISSN: 1472-4472.

Musiek ES, Milne GL, McLaughlin B, Morrow JD. Cyclopentenone eicosanoids as mediators of neurodegeneration: a pathogenic mechanism of oxidative stress-mediated and cyclooxygenase-mediated neurotoxicity. Brain Pathol. 2005 Apr; 15(2): 149-58. PMID: 15912888, PMCID: PMC2881556, ISSN: 1015-6305.

Goy A, Younes A, McLaughlin P, Pro B, Romaguera JE, Hagemeister F, Fayad L, Dang NH, Samaniego F, Wang M, Broglio K, Samuels B, Gilles F, Sarris AH, Hart S, Trehu E, Schenkein D, Cabanillas F, Rodriguez AM. Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma. J. Clin. Oncol [print-electronic]. 2005 Feb 2/1/2005; 23(4): 667-75. PMID: 15613697, PII: JCO.2005.03.108, DOI: 10.1200/JCO.2005.03.108, ISSN: 0732-183X.

McLaughlin B. The kinder side of killer proteases: caspase activation contributes to neuroprotection and CNS remodeling. Apoptosis. 2004 Mar; 9(2): 111-21. PMID: 15004508, PMCID: PMC2879070, PII: 5268888, DOI: 10.1023/B:APPT.0000018793.10779.dc, ISSN: 1360-8185.

Tonomura N, McLaughlin K, Grimm L, Goldsby RA, Osborne BA. Glucocorticoid-induced apoptosis of thymocytes: requirement of proteasome-dependent mitochondrial activity. J. Immunol. 2003 Mar 3/1/2003; 170(5): 2469-78. PMID: 12594272, ISSN: 0022-1767.

McLaughlin B, Hartnett KA, Erhardt JA, Legos JJ, White RF, Barone FC, Aizenman E. Caspase 3 activation is essential for neuroprotection in preconditioning. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Jan 1/21/2003; 100(2): 715-20. PMID: 12522260, PMCID: PMC141062, PII: 0232966100, DOI: 10.1073/pnas.0232966100, ISSN: 0027-8424.

Leszkiewicz DN, McLaughlin BA, Aizenman E. Protein kinases and light: unlikely partners in a receptor localization puzzle. Physiol. Behav. 2002 Dec; 77(4-5): 533-6. PMID: 12526995, PII: S0031938402009113, ISSN: 0031-9384.

Du S, McLaughlin B, Pal S, Aizenman E. In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway. J. Neurosci. 2002 Sep 9/1/2002; 22(17): 7408-16. PMID: 12196562, PII: 22/17/7408, ISSN: 1529-2401.

Legos JJ, McLaughlin B, Skaper SD, Strijbos PJ, Parsons AA, Aizenman E, Herin GA, Barone FC, Erhardt JA. The selective p38 inhibitor SB-239063 protects primary neurons from mild to moderate excitotoxic injury. Eur. J. Pharmacol. 2002 Jun 6/28/2002; 447(1): 37-42. PMID: 12106800, PII: S0014299902018903, ISSN: 0014-2999.

McLaughlin B, Pal S, Tran MP, Parsons AA, Barone FC, Erhardt JA, Aizenman E. P38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis. J. Neurosci. 2001 May 5/15/2001; 21(10): 3303-11. PMID: 11331359, PMCID: PMC3746747, PII: 21/10/3303, ISSN: 1529-2401.

Nuttall ME, Lee D, McLaughlin B, Erhardt JA. Selective inhibitors of apoptotic caspases: implications for novel therapeutic strategies. Drug Discov. Today. 2001 Jan 1/1/2001; 6(2): 85-91. PMID: 11166256, PII: S1359-6446(00)01601-9, ISSN: 1878-5832.

McLaughlin B.A. Dopamine neurotoxicity and neurodegeneration. In Molecular Mechanisms of Cell Death. Chesselet M.F. ed Humana Press. Totowa, N.J. p. 195-231. Molecular Mechanisms of Cell Death. Chesselet M.F. 2001; 195-231.

Hoyt KR, McLaughlin BA, Higgins DS, Reynolds IJ. Inhibition of glutamate-induced mitochondrial depolarization by tamoxifen in cultured neurons. J. Pharmacol. Exp. Ther. 2000 May; 293(2): 480-6. PMID: 10773018, ISSN: 0022-3565.

Gardner RC, Assinder SJ, Christie G, Mason GG, Markwell R, Wadsworth H, McLaughlin M, King R, Chabot-Fletcher MC, Breton JJ, Allsop D, Rivett AJ. Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells. Biochem. J. 2000 Mar 3/1/2000; 346 Pt 2: 447-54. PMID: 10677365, PMCID: PMC1220872, ISSN: 0264-6021.

Aizenman E., Stout A.K., Hartnett K.A., Dineley K.E., McLaughlin B.A., Reynolds I.J. Induction of neuronal apoptosis by thiol oxidation: Putative role of intracellular zinc release. Journal of Neurochemistry. 2000; 5((75)): 1878-88.

Christie G, Markwell RE, Gray CW, Smith L, Godfrey F, Mansfield F, Wadsworth H, King R, McLaughlin M, Cooper DG, Ward RV, Howlett DR, Hartmann T, Lichtenthaler SF, Beyreuther K, Underwood J, Gribble SK, Cappai R, Masters CL, Tamaoka A, Gardner RL, Rivett AJ, Karran EH, Allsop D. Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome. J. Neurochem. 1999 Jul; 73(1): 195-204. PMID: 10386971, ISSN: 0022-3042.

McLaughlin B.A. and Levitt P. Molecular basis of neurological disease. Neuroscience Secrets. 1999; Hanley & Belfus, Inc., Philadelphia PA.((edited by Wong-Riley M.T.T. )): 349-56.

McLaughlin BA, Nelson D, Silver IA, Erecinska M, Chesselet MF. Methylmalonate toxicity in primary neuronal cultures. Neuroscience. 1998 Sep; 86(1): 279-90. PMID: 9692761, PII: S0306-4522(97)00594-0, ISSN: 0306-4522.

McLaughlin BA, Nelson D, Erecinska M, Chesselet MF. Toxicity of dopamine to striatal neurons in vitro and potentiation of cell death by a mitochondrial inhibitor. J. Neurochem. 1998 Jun; 70(6): 2406-15. PMID: 9603205, ISSN: 0022-3042.

McLaughlin BA, Spencer C, Eberwine J. CAG trinucleotide RNA repeats interact with RNA-binding proteins. Am. J. Hum. Genet. 1996 Sep; 59(3): 561-9. PMID: 8751857, PMCID: PMC1914904, ISSN: 0002-9297.

Robinson MB, Hopkins K, Batshaw ML, McLaughlin BA, Heyes MP, Oster-Granite ML. Evidence of excitotoxicity in the brain of the ornithine carbamoyltransferase deficient sparse fur mouse. Brain Res. Dev. Brain Res. 1995 Dec 12/21/1995; 90(1-2): 35-44. PMID: 8777776, ISSN: 0165-3806.

Batshaw ML, Yudkoff M, McLaughlin BA, Gorry E, Anegawa NJ, Smith IA, Hyman SL, Robinson MB. The sparse fur mouse as a model for gene therapy in ornithine carbamoyltransferase deficiency. Gene Ther. 1995 Dec; 2(10): 743-9. PMID: 8750014, ISSN: 0969-7128.

Eberwine J.H. and McLaughlin B.A.. Molecular and Cellular Mechanisms of Neostriatal Function. [place unknown: publisher unknown]; 1995. (Ariano M.A. and Surmeier D.J. eds).