Robbert J. C. Slebos, Ph.D.

Research Associate Professor

r.slebos@vanderbilt.edu
Faculty Appointments
Research Associate Professor of Biochemistry Research Associate Professor of Cancer Biology
Education
M.S., Clinical Research, Duke University, Durham, North CarolinaPh.D., Molecular Biology, University of Amsterdam, AmsterdamM.Sc., Molecular & Cell Biology, Utrecht University, UtrechtB.Sc., Biology/Chemistry, Utrecht University, Utrecht
Office Address
Ayers Institute
U1213A, Medical Research Building III
465 21st Avenue South
Nashville, TN 37232
Research Keywords
Translational research using shotgun proteomics for the detection of biomarkers of early detection, response prediction and prognosis of colorectal cancer and head and neck cancer.
Publications
Lin D, Li J, Slebos RJ, Liebler DC. Cysteinyl peptide capture for shotgun proteomics: global assessment of chemoselective fractionation. J. Proteome Res. 2010 Oct 10/1/2010; 9(10): 5461-72. PMID: 20731415, PMCID: PMC2948434, DOI: 10.1021/pr1007015, ISSN: 1535-3907.

Tu C, Rudnick PA, Martinez MY, Cheek KL, Stein SE, Slebos RJ, Liebler DC. Depletion of abundant plasma proteins and limitations of plasma proteomics. J. Proteome Res. 2010 Oct 10/1/2010; 9(10): 4982-91. PMID: 20677825, PMCID: PMC2948641, DOI: 10.1021/pr100646w, ISSN: 1535-3907.

Li M, Gray W, Zhang H, Chung CH, Billheimer D, Yarbrough WG, Liebler DC, Shyr Y, Slebos RJ. Comparative shotgun proteomics using spectral count data and quasi-likelihood modeling. J. Proteome Res. 2010 Aug 8/6/2010; 9(8): 4295-305. PMID: 20586475, PMCID: PMC2920032, DOI: 10.1021/pr100527g, ISSN: 1535-3907.

Dasari S, Chambers MC, Slebos RJ, Zimmerman LJ, Ham AJ, Tabb DL. TagRecon: high-throughput mutation identification through sequence tagging. J. Proteome Res. 2010 Apr 4/5/2010; 9(4): 1716-26. PMID: 20131910, PMCID: PMC2859315, DOI: 10.1021/pr900850m, ISSN: 1535-3907.

Chung CH, Aulino J, Muldowney NJ, Hatakeyama H, Baumann J, Burkey B, Netterville J, Sinard R, Yarbrough WG, Cmelak AJ, Slebos RJ, Shyr Y, Parker J, Gilbert J, Murphy BA. Nuclear factor-kappa B pathway and response in a phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Ann. Oncol [print-electronic]. 2010 Apr; 21(4): 864-70. PMID: 19850643, PMCID: PMC2844946, PII: mdp390, DOI: 10.1093/annonc/mdp390, ISSN: 1569-8041.

Hatakeyama H, Cheng H, Wirth P, Counsell A, Marcrom SR, Wood CB, Pohlmann PR, Gilbert J, Murphy B, Yarbrough WG, Wheeler DL, Harari PM, Guo Y, Shyr Y, Slebos RJ, Chung CH. Regulation of heparin-binding EGF-like growth factor by miR-212 and acquired cetuximab-resistance in head and neck squamous cell carcinoma. PLoS ONE. 2010; 5(9): e12702. PMID: 20856931, PMCID: PMC2938338, DOI: 10.1371/journal.pone.0012702, ISSN: 1932-6203.

Fiske WH, Tanksley J, Nam KT, Goldenring JR, Slebos RJ, Liebler DC, Abtahi AM, La Fleur B, Ayers GD, Lind CD, Washington MK, Coffey RJ. Efficacy of cetuximab in the treatment of Menetrier's disease. Sci Transl Med. 2009 Nov 11/25/2009; 1(8): 8ra18. PMID: 20368185, PMCID: PMC3638759, PII: 1/8/8ra18, DOI: 10.1126/scitranslmed.3000320, ISSN: 1946-6242.

Baumann JL, Cohen S, Evjen AN, Law JH, Vadivelu S, Attia A, Schindler JS, Chung CH, Wirth PS, Meijer CJ, Snijders PJ, Yarbrough WG, Slebos RJ. Human papillomavirus in early laryngeal carcinoma. Laryngoscope. 2009 Aug; 119(8): 1531-7. PMID: 19489068, DOI: 10.1002/lary.20509, ISSN: 1531-4995.

Sprung RW, Brock JW, Tanksley JP, Li M, Washington MK, Slebos RJ, Liebler DC. Equivalence of protein inventories obtained from formalin-fixed paraffin-embedded and frozen tissue in multidimensional liquid chromatography-tandem mass spectrometry shotgun proteomic analysis. Mol. Cell Proteomics [print-electronic]. 2009 Aug; 8(8): 1988-98. PMID: 19467989, PMCID: PMC2722776, PII: M800518-MCP200, DOI: 10.1074/mcp.M800518-MCP200, ISSN: 1535-9484.

Slebos RJ, Brock JW, Winters NF, Stuart SR, Martinez MA, Li M, Chambers MC, Zimmerman LJ, Ham AJ, Tabb DL, Liebler DC. Evaluation of strong cation exchange versus isoelectric focusing of peptides for multidimensional liquid chromatography-tandem mass spectrometry. J. Proteome Res. 2008 Dec; 7(12): 5286-94. PMID: 18939861, PMCID: PMC2669493, DOI: 10.1021/pr8004666, ISSN: 1535-3893.

Luo W, Slebos RJ, Hill S, Li M, Brábek J, Amanchy R, Chaerkady R, Pandey A, Ham AJ, Hanks SK. Global impact of oncogenic Src on a phosphotyrosine proteome. J. Proteome Res [print-electronic]. 2008 Aug; 7(8): 3447-60. PMID: 18563927, PMCID: PMC2579752, DOI: 10.1021/pr800187n, ISSN: 1535-3893.

Palka KT, Slebos RJ, Chung CH. Update on molecular diagnostic tests in head and neck cancer. Semin. Oncol. 2008 Jun; 35(3): 198-210. PMID: 18544435, PMCID: PMC2490629, PII: S0093-7754(08)00065-1, DOI: 10.1053/j.seminoncol.2008.03.002, ISSN: 0093-7754.

Chung CH, Mirakhur B, Chan E, Le QT, Berlin J, Morse M, Murphy BA, Satinover SM, Hosen J, Mauro D, Slebos RJ, Zhou Q, Gold D, Hatley T, Hicklin DJ, Platts-Mills TA. Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose. N. Engl. J. Med. 2008 Mar 3/13/2008; 358(11): 1109-17. PMID: 18337601, PMCID: PMC2361129, PII: 358/11/1109, DOI: 10.1056/NEJMoa074943, ISSN: 1533-4406.

Slebos RJ, Li M, Vadivelu S, Burkey BB, Netterville JL, Sinard R, Gilbert J, Murphy B, Chung CH, Shyr Y, Yarbrough WG. Microsatellite mutations in buccal cells are associated with aging and head and neck carcinoma. Br. J. Cancer [print-electronic]. 2008 Feb 2/12/2008; 98(3): 619-26. PMID: 18212747, PMCID: PMC2243146, PII: 6604198, DOI: 10.1038/sj.bjc.6604198, ISSN: 0007-0920.

Yim HW, Slebos RJ, Randell SH, Umbach DM, Parsons AM, Rivera MP, Detterbeck FC, Taylor JA. Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells. Cancer Lett [print-electronic]. 2007 Feb 2/8/2007; 246(1-2): 24-33. PMID: 16517060, PII: S0304-3835(06)00073-5, DOI: 10.1016/j.canlet.2006.01.023, ISSN: 0304-3835.

Flake GP, Rivera MP, Funkhouser WK, Maygarden SJ, Meadows KL, Long EH, Stockton PS, Jones TC, Yim HW, Slebos RJ, Taylor JA. Detection of pre-invasive lung cancer: technical aspects of the LIFE project. Toxicol Pathol. 2007 Jan; 35(1): 65-74. PMID: 17325974, PII: 770781602, DOI: 10.1080/01926230601052659, ISSN: 0192-6233.

Yarbrough WG, Whigham A, Brown B, Roach M, Slebos R. Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas. Int. J. Radiat. Oncol. Biol. Phys. 2007; 69(2 Suppl): S98-101. PMID: 17848307, PII: S0360-3016(07)00951-0, DOI: 10.1016/j.ijrobp.2007.04.082, ISSN: 0360-3016.

Chung CH, Parker J, Levy S, Slebos RJ, Dicker AP, Rodeck U. Gene expression profiles as markers of aggressive disease-EGFR as a factor. Int. J. Radiat. Oncol. Biol. Phys. 2007; 69(2 Suppl): S102-5. PMID: 17848272, PMCID: PMC2361130, PII: S0360-3016(07)00963-7, DOI: 10.1016/j.ijrobp.2007.05.039, ISSN: 0360-3016.

Slebos RJ, Li M, Evjen AN, Coffa J, Shyr Y, Yarbrough WG. Mutagenic effect of cadmium on tetranucleotide repeats in human cells. Mutat. Res [print-electronic]. 2006 Dec 12/1/2006; 602(1-2): 92-9. PMID: 16989872, PII: S0027-5107(06)00260-0, DOI: 10.1016/j.mrfmmm.2006.08.003, ISSN: 0027-5107.

Chung CH, Ely K, McGavran L, Varella-Garcia M, Parker J, Parker N, Jarrett C, Carter J, Murphy BA, Netterville J, Burkey BB, Sinard R, Cmelak A, Levy S, Yarbrough WG, Slebos RJ, Hirsch FR. Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J. Clin. Oncol. 2006 Sep 9/1/2006; 24(25): 4170-6. PMID: 16943533, PII: 24/25/4170, DOI: 10.1200/JCO.2006.07.2587, ISSN: 1527-7755.

Chung CH, Parker JS, Ely K, Carter J, Yi Y, Murphy BA, Ang KK, El-Naggar AK, Zanation AM, Cmelak AJ, Levy S, Slebos RJ, Yarbrough WG. Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappaB signaling as characteristics of a high-risk head and neck squamous cell carcinoma. Cancer Res. 2006 Aug 8/15/2006; 66(16): 8210-8. PMID: 16912200, PII: 66/16/8210, DOI: 10.1158/0008-5472.CAN-06-1213, ISSN: 1538-7445.

Yarbrough WG, Slebos RJ, Liebler D. Proteomics: clinical applications for head and neck squamous cell carcinoma. Head Neck. 2006 Jun; 28(6): 549-58. PMID: 16475197, DOI: 10.1002/hed.20357, ISSN: 1043-3074.

Slebos RJ, Yi Y, Ely K, Carter J, Evjen A, Zhang X, Shyr Y, Murphy BM, Cmelak AJ, Burkey BB, Netterville JL, Levy S, Yarbrough WG, Chung CH. Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma. Clin. Cancer Res. 2006 Feb 2/1/2006; 12(3 Pt 1): 701-9. PMID: 16467079, PII: 12/3/701, DOI: 10.1158/1078-0432.CCR-05-2017, ISSN: 1078-0432.

Slebos RJ, Livanos E, Yim HW, Randell SH, Parsons AM, Detterbeck FC, Rivera MP, Taylor JA. Chromosomal abnormalities in bronchial epithelium from smokers, nonsmokers, and lung cancer patients. Cancer Genet. Cytogenet. 2005 Jun; 159(2): 137-42. PMID: 15899385, PII: S0165-4608(04)00505-9, DOI: 10.1016/j.cancergencyto.2004.10.008, ISSN: 0165-4608.

Slebos RJ, Umbach DM, Sommer CA, Horner GA, Choi JY, Taylor JA. Analytical and statistical methods to evaluate microsatellite allelic imbalance in small amounts of DNA. Lab. Invest. 2004 May; 84(5): 649-57. PMID: 15048133, PII: 3700076, DOI: 10.1038/labinvest.3700076, ISSN: 0023-6837.

Slebos RJ, Little RE, Umbach DM, Antipkin Y, Zadaorozhnaja TD, Mendel NA, Sommer CA, Conway K, Parrish E, Gulino S, Taylor JA. Mini-and microsatellite mutations in children from Chernobyl accident cleanup workers. Mutat. Res. 2004 Apr 4/11/2004; 559(1-2): 143-51. PMID: 15066582, PII: S1383571804000099, DOI: 10.1016/j.mrgentox.2004.01.003, ISSN: 0027-5107.

Jin YH, Clark AB, Slebos RJ, Al-Refai H, Taylor JA, Kunkel TA, Resnick MA, Gordenin DA. Cadmium is a mutagen that acts by inhibiting mismatch repair. Nat. Genet. 2003 Jul; 34(3): 326-9. PMID: 12796780, PMCID: PMC2662193, PII: ng1172, DOI: 10.1038/ng1172, ISSN: 1061-4036.

Slebos RJ, Oh DS, Umbach DM, Taylor JA. Mutations in tetranucleotide repeats following DNA damage depend on repeat sequence and carcinogenic agent. Cancer Res. 2002 Nov 11/1/2002; 62(21): 6052-60. PMID: 12414628, ISSN: 0008-5472.

Slebos RJ, Taylor JA. A novel host cell reactivation assay to assess homologous recombination capacity in human cancer cell lines. Biochem. Biophys. Res. Commun. 2001 Feb 2/16/2001; 281(1): 212-9. PMID: 11178982, PII: S0006-291X(01)94335-9, DOI: 10.1006/bbrc.2001.4335, ISSN: 0006-291X.

Slebos RJ, Hoppin JA, Tolbert PE, Holly EA, Brock JW, Zhang RH, Bracci PM, Foley J, Stockton P, McGregor LM, Flake GP, Taylor JA. K-ras and p53 in pancreatic cancer: association with medical history, histopathology, and environmental exposures in a population-based study. Cancer Epidemiol. Biomarkers Prev. 2000 Nov; 9(11): 1223-32. PMID: 11097231, ISSN: 1055-9965.

Lax SF, Kendall B, Tashiro H, Slebos RJ, Hedrick L. The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways. Cancer. 2000 Feb 2/15/2000; 88(4): 814-24. PMID: 10679651, PII: 10.1002/(SICI)1097-0142(20000215)88:4<814::AID-CNCR12>3.0.CO;2-U, ISSN: 0008-543X.

Slebos RJ, Resnick MA, Taylor JA. Inactivation of the p53 tumor suppressor gene via a novel Alu rearrangement. Cancer Res. 1998 Dec 12/1/1998; 58(23): 5333-6. PMID: 9850060, ISSN: 0008-5472.

Ceha HM, Nasser I, Medema RH, Slebos RJ. Several noncontiguous domains of CDK4 are involved in binding to the P16 tumor suppressor protein. Biochem. Biophys. Res. Commun. 1998 Aug 8/19/1998; 249(2): 550-5. PMID: 9712735, PII: S0006-291X(98)99183-5, DOI: 10.1006/bbrc.1998.9183, ISSN: 0006-291X.

Slebos RJ, Baas IO, Clement MJ, Offerhaus GJ, Askin FB, Hruban RH, Westra WH. P53 alterations in atypical alveolar hyperplasia of the human lung. Hum. Pathol. 1998 Aug; 29(8): 801-8. PMID: 9712420, ISSN: 0046-8177.

Ceha HM, Clement MJ, Polak MM, Offerhaus GJ, Slebos RJ. Mutational analysis of the P16-binding domain of cyclin-dependent kinase 4 in tumors in the head region of the pancreas. Pancreas. 1998 Jul; 17(1): 85-8. PMID: 9667525, ISSN: 0885-3177.

Wilentz RE, Chung CH, Sturm PD, Musler A, Sohn TA, Offerhaus GJ, Yeo CJ, Hruban RH, Slebos RJ. K-ras mutations in the duodenal fluid of patients with pancreatic carcinoma. Cancer. 1998 Jan 1/1/1998; 82(1): 96-103. PMID: 9428484, PII: 10.1002/(SICI)1097-0142(19980101)82:1<96::AID-CNCR11>3.0.CO;2-8, ISSN: 0008-543X.

Hruban RH, Sturm PD, Slebos RJ, Wilentz RE, Musler AR, Yeo CJ, Sohn TA, van Velthuysen ML, Offerhaus GJ. Can K-ras codon 12 mutations be used to distinguish benign bile duct proliferations from metastases in the liver? A molecular analysis of 101 liver lesions from 93 patients. Am. J. Pathol. 1997 Oct; 151(4): 943-9. PMID: 9327727, PMCID: PMC1858056, ISSN: 0002-9440.

Entius MM, Westerman AM, Giardiello FM, van Velthuysen ML, Polak MM, Slebos RJ, Wilson JH, Hamilton SR, Offerhaus GJ. Peutz-Jeghers polyps, dysplasia, and K-ras codon 12 mutations. Gut. 1997 Sep; 41(3): 320-2. PMID: 9378385, PMCID: PMC1891488, ISSN: 0017-5749.

Dijkhuizen SM, Entius MM, Clement MJ, Polak MM, Van den Berg FM, Craanen ME, Slebos RJ, Offerhaus GJ. Multiple hyperplastic polyps in the stomach: evidence for clonality and neoplastic potential. Gastroenterology. 1997 Feb; 112(2): 561-6. PMID: 9024310, PII: S0016508597000887, ISSN: 0016-5085.

Rodenhuis S, Boerrigter L, Top B, Slebos RJ, Mooi WJ, van't Veer L, van Zandwijk N. Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective study. J. Clin. Oncol. 1997 Jan; 15(1): 285-91. PMID: 8996154, ISSN: 0732-183X.

Slebos RJ, Baas IO, Clement M, Polak M, Mulder JW, van den Berg FM, Hamilton SR, Offerhaus GJ. Clinical and pathological associations with p53 tumour-suppressor gene mutations and expression of p21WAF1/Cip1 in colorectal carcinoma. Br. J. Cancer. 1996 Jul; 74(2): 165-71. PMID: 8688317, PMCID: PMC2074586, ISSN: 0007-0920.

Chung CH, Wilentz RE, Polak MM, Ramsoekh TB, Noorduyn LA, Gouma DJ, Huibregtse K, Offerhaus GJ, Slebos RJ. Clinical significance of K-ras oncogene activation in ampullary neoplasms. J. Clin. Pathol. 1996 Jun; 49(6): 460-4. PMID: 8763258, PMCID: PMC500534, ISSN: 0021-9746.

Westra WH, Baas IO, Hruban RH, Askin FB, Wilson K, Offerhaus GJ, Slebos RJ. K-ras oncogene activation in atypical alveolar hyperplasias of the human lung. Cancer Res. 1996 May 5/1/1996; 56(9): 2224-8. PMID: 8616876, ISSN: 0008-5472.

Baas IO, van den Berg FM, Mulder JW, Clement MJ, Slebos RJ, Hamilton SR, Offerhaus GJ. Potential false-positive results with antigen enhancement for immunohistochemistry of the p53 gene product in colorectal neoplasms. J. Pathol. 1996 Mar; 178(3): 264-7. PMID: 8778330, PII: 10.1002/(SICI)1096-9896(199603)178:3<264::AID-PATH485>3.0.CO;2-#, DOI: 10.1002/(SICI)1096-9896(199603)178:3<264::AID-PATH485>3.0.CO;2-#, ISSN: 0022-3417.

Offerhaus GJ, Slebos RJ. [Molecular-genetic detection of colorectal carcinoma in the feces]. Ned Tijdschr Geneeskd. 1995 Dec 12/30/1995; 139(52): 2714-5. PMID: 8569883, ISSN: 0028-2162.

Slebos RJ, Kessis TD, Chen AW, Han SM, Hedrick L, Cho KR. Functional consequences of directed mutations in human papillomavirus E6 proteins: abrogation of p53-mediated cell cycle arrest correlates with p53 binding and degradation in vitro. Virology. 1995 Apr 4/1/1995; 208(1): 111-20. PMID: 11831691, PII: S0042-6822(85)71134-8, DOI: 10.1006/viro.1995.1134, ISSN: 0042-6822.

Slebos RJ, Lee MH, Plunkett BS, Kessis TD, Williams BO, Jacks T, Hedrick L, Kastan MB, Cho KR. P53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc. Natl. Acad. Sci. U.S.A. 1994 Jun 6/7/1994; 91(12): 5320-4. PMID: 8202487, PMCID: PMC43986, ISSN: 0027-8424.

Kern JA, Slebos RJ, Top B, Rodenhuis S, Lager D, Robinson RA, Weiner D, Schwartz DA. C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas. J. Clin. Invest. 1994 Feb; 93(2): 516-20. PMID: 7906694, PMCID: PMC293872, DOI: 10.1172/JCI117001, ISSN: 0021-9738.

Kessis TD, Slebos RJ, Han SM, Shah K, Bosch XF, Muñoz N, Hedrick L, Cho KR. P53 gene mutations and MDM2 amplification are uncommon in primary carcinomas of the uterine cervix. Am. J. Pathol. 1993 Nov; 143(5): 1398-405. PMID: 8238255, PMCID: PMC1887168, ISSN: 0002-9440.

Slichenmyer WJ, Nelson WG, Slebos RJ, Kastan MB. Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. Cancer Res. 1993 Sep 9/15/1993; 53(18): 4164-8. PMID: 8364909, ISSN: 0008-5472.

Westra WH, Slebos RJ, Offerhaus GJ, Goodman SN, Evers SG, Kensler TW, Askin FB, Rodenhuis S, Hruban RH. K-ras oncogene activation in lung adenocarcinomas from former smokers. Evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung. Cancer. 1993 Jul 7/15/1993; 72(2): 432-8. PMID: 8319174, ISSN: 0008-543X.

Kessis TD, Slebos RJ, Nelson WG, Kastan MB, Plunkett BS, Han SM, Lorincz AT, Hedrick L, Cho KR. Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. Proc. Natl. Acad. Sci. U.S.A. 1993 May 5/1/1993; 90(9): 3988-92. PMID: 8387205, PMCID: PMC46431, ISSN: 0027-8424.

Westra WH, Offerhaus GJ, Goodman SN, Slebos RJ, Polak M, Baas IO, Rodenhuis S, Hruban RH. Overexpression of the p53 tumor suppressor gene product in primary lung adenocarcinomas is associated with cigarette smoking. Am. J. Surg. Pathol. 1993 Mar; 17(3): 213-20. PMID: 8434702, ISSN: 0147-5185.

Slebos RJ, Boerrigter L, Evers SG, Wisman P, Mooi WJ, Rodenhuis S. A rapid and simple procedure for the routine detection of ras point mutations in formalin-fixed, paraffin-embedded tissues. Diagn. Mol. Pathol. 1992 Jun; 1(2): 136-41. PMID: 1342959, ISSN: 1052-9551.

Rodenhuis S, Slebos RJ. Clinical significance of ras oncogene activation in human lung cancer. Cancer Res. 1992 May 5/1/1992; 52(9 Suppl): 2665s-2669s. PMID: 1562997, ISSN: 0008-5472.

Slebos RJ, Rodenhuis S. The ras gene family in human non-small-cell lung cancer. J. Natl. Cancer Inst. Monographs. 1992; (13): 23-9. PMID: 1327034, ISSN: 1052-6773.

Oudejans JJ, Slebos RJ, Zoetmulder FA, Mooi WJ, Rodenhuis S. Differential activation of ras genes by point mutation in human colon cancer with metastases to either lung or liver. Int. J. Cancer. 1991 Dec 12/2/1991; 49(6): 875-9. PMID: 1959991, ISSN: 0020-7136.

Rygaard K, Slebos RJ, Spang-Thomsen M. Radiosensitivity of small-cell lung cancer xenografts compared with activity of c-myc, N-myc, L-myc, c-raf-1 and K-ras proto-oncogenes. Int. J. Cancer. 1991 Sep 9/9/1991; 49(2): 279-84. PMID: 1652570, ISSN: 0020-7136.

Slebos RJ, Hruban RH, Dalesio O, Mooi WJ, Offerhaus GJ, Rodenhuis S. Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung. J. Natl. Cancer Inst. 1991 Jul 7/17/1991; 83(14): 1024-7. PMID: 2072410, ISSN: 0027-8874.

Slebos RJ, Habets GG, Evers SG, Mooi WJ, Rodenhuis S. Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas. Int. J. Cancer. 1991 Apr 4/22/1991; 48(1): 51-6. PMID: 1850383, ISSN: 0020-7136.

Breuer M, Wientjens E, Verbeek S, Slebos R, Berns A. Carcinogen-induced lymphomagenesis in pim-1 transgenic mice: dose dependence and involvement of myc and ras. Cancer Res. 1991 Feb 2/1/1991; 51(3): 958-63. PMID: 1988138, ISSN: 0008-5472.

Rodenhuis S, Slebos RJ. The ras oncogenes in human lung cancer. Am. Rev. Respir. Dis. 1990 Dec; 142(6 Pt 2): S27-30. PMID: 2252272, DOI: 10.1164/ajrccm/142.6_Pt_2.S27, ISSN: 0003-0805.

Slebos RJ, Kibbelaar RE, Dalesio O, Kooistra A, Stam J, Meijer CJ, Wagenaar SS, Vanderschueren RG, van Zandwijk N, Mooi WJ. K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung. N. Engl. J. Med. 1990 Aug 8/30/1990; 323(9): 561-5. PMID: 2199829, DOI: 10.1056/NEJM199008303230902, ISSN: 0028-4793.

Breuer M, Slebos R, Verbeek S, van Lohuizen M, Wientjens E, Berns A. Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice. Nature. 1989 Jul 7/6/1989; 340(6228): 61-3. PMID: 2786994, DOI: 10.1038/340061a0, ISSN: 0028-0836.

Slebos RJ, Rodenhuis S. The molecular genetics of human lung cancer. Eur. Respir. J. 1989 May; 2(5): 461-9. PMID: 2547647, ISSN: 0903-1936.

Slebos RJ, Evers SG, Wagenaar SS, Rodenhuis S. Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer. Br. J. Cancer. 1989 Jan; 59(1): 76-80. PMID: 2547415, PMCID: PMC2246978, ISSN: 0007-0920.

Rodenhuis S, Slebos RJ, Boot AJ, Evers SG, Mooi WJ, Wagenaar SS, van Bodegom PC, Bos JL. Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. Cancer Res. 1988 Oct 10/15/1988; 48(20): 5738-41. PMID: 3048648, ISSN: 0008-5472.

Slebos RJ, de Graeff A, Van Zandwijk N, Mooi WJ, Bos JL, Rodenhuis S. Recurrent breast cancer and an adenocarcinoma of the lung occurring in one patient: c-myc oncogene amplification and K-ras codon 12 point mutation as tumour markers. Eur J Cancer Clin Oncol. 1988 Sep; 24(9): 1529-30. PMID: 3181273, ISSN: 0277-5379.

Höppener JW, Mosselman S, Roholl PJ, Lambrechts C, Slebos RJ, de Pagter-Holthuizen P, Lips CJ, Jansz HS, Sussenbach JS. Expression of insulin-like growth factor-I and -II genes in human smooth muscle tumours. EMBO J. 1988 May; 7(5): 1379-85. PMID: 3409868, PMCID: PMC458387, ISSN: 0261-4189.

de Graeff A, Slebos RJ, Rodenhuis S. Resistance to cisplatin and analogues: mechanisms and potential clinical implications. Cancer Chemother. Pharmacol. 1988; 22(4): 325-32. PMID: 3048763, ISSN: 0344-5704.

Höppener JW, Steenbergh PH, Slebos RJ, de Pagter-Holthuizen P, Roos BA, Jansen M, Van den Brande JL, Sussenbach JS, Jansz HS, Lips CJ. Expression of insulin-like growth factor-I and -II genes in rat medullary thyroid carcinoma. FEBS Lett. 1987 May 5/4/1987; 215(1): 122-6. PMID: 2883027, PII: 0014-5793(87)80125-4, ISSN: 0014-5793.

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