Richard L. Printz, Ph.D.

Research Assistant Professor

richard.printz@vanderbilt.edu
Faculty Appointments
Research Assistant Professor of Molecular Physiology and Biophysics
Education
Ph.D., Mol Physiol/Biophys, Vanderbilt University, Nashville, TennesseeB.S., Biochem & Premedicine, Pennsylvania State University, University Park, Pennsylvania
Office Address
702 Light Hall
TN 0615
Publications
Vogt C, Yki-Jarvinen H, Iozzo P, Pipek R, Pendergrass M, Koval J, Ardehali H, Printz R, Granner D, Defronzo R, Mandarino L. Effects of insulin on subcellular localization of hexokinase II in human skeletal muscle in vivo. J Clin Endocrinol Metab. 1998; 83: 230-4.

Koval JA, DeFronzo RA, O?Doherty RM, Printz R, Ardehali H, Granner DK, Mandarino LJ. Regulation of hexokinase II activity and expression in human muscle by moderate exercise. Am J Physiol. 1998; 274.

Pendergrass M, Koval J, Vogt C, Yki-Jarvinen H, Iozzo P, Pipek R, Ardehali H, Printz R, Granner D, DeFronzo RA, Mandarino LJ. Insulin-induced hexokinase II expression is reduced in obesity and NIDDM. Diabetes. 1998; 47: 387-94.

Printz RL, Osawa H, Ardehali H, Koch S, Granner DK. Hexokinase II gene: structure, regulation and promoter organization. Biochem Soc Trans. 1997; 25: 107-12.

Robey, R.B., Osawa, H., Printz, R.L. and Granner, D.K. Transient Gene Transfer into Myotubes Following Differentiation in Culture. BioTechniques. 1996; 20: 40-2.

Ardehali, H., Yano, Y., Printz, R.L., Koch, S., Whitesell, R.R., May, J.M. and Granner, D.K. Functional Organization of Mammalian Hexokinase II. J. Biol. Chem. 1996; 271: 1849-52.

Shimada, F., Hashimoto, N., Kanatsuka, A., Printz, R.L., Granner, D.K., Makino, H. Identification of the Aminoacid Polymorphisms in Hexokinase II in Japanese Subjects. Letter to the editors, Diabetologia. 1996; 39: 123-4.

Ardehali, H., Tiller, G.E., Printz, R.L., Mochizuki, H., Prochazka, M. and Granner, D.K. A Novel (TA)n Polymorphism in the Hexokinase II Gene: Application to NIDDM in the Pima Indians. Human Genetics. 1996; 97: 482-5.

Osawa, H., Sutherland, C., Robey, R.B., Printz, R.L. and Granner, D.K. Analysis of the Signaling Pathway Involved in the Regulation of Hexokinase II Gene Transcription by Insulin. J. Biol. Chem. 1996; 271: 16690-4.

Osawa, H., Robey, R.B., Printz, R.L. and Granner, D.K. Identification and Characterization of Basal and Cyclic AMP Response Elements in the Promoter of the Rat Hexokinase II Gene. J. Biol. Chem. 1996; 271: 17296-303.

Ludwig, D. S., Vidal-Puig, A., O?Brien, R. M., Printz, R. L., Granner, D. K., et al. Examination of the phosphoenolpyruvate carboxykinase gene promoter in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1996; 81: 503-6.

Chang, P.-Y., Jensen, J., Printz, R.L., Granner, D.K., Ivy, J.L. and Moller, D.E. Overexpression of Hexokinase II in Transgenic Mice: Evidence that Increased Phosphorylation Augments Muscle Glucose Uptake. J. Biol. Chem. 1996; 271: 14834-9.

Taylor RW, Printz RL, Armstrong M, Granner DK, Alberti KG, Turnbull DM, Walker M. Variant sequences of the Hexokinase II gene in familial NIDDM. Diabetologia. 1996; 39: 322-8.

Printz, R.L., Ardehali, H., Koch, S. and Granner, D.K. Human Hexokinase II mRNA and Gene Structure. Diabetes. 1995; 44: 290-4.

Vidal-Puig, A., Printz, R.L., Stratton, I.M., Granner, D.K. and Moller, D.E. Analysis of the Hexokinase II Gene in Subjects with Insulin Resistance and NIDDM and Detection of a Gln142 His Substitution. Diabetes. 1995; 44: 340-6.

Echwald, S.M., Bjorbaek, C., Hansen, T., Clausen, J.O., Vestergaard, H., Zierath, J.R., Printz, R.L., Granner, D.K. and Pedersen, O. Identification of Four Amino Acid Substitutions in Hexokinase II and Studies of Relationships to NIDDM, Glucose Efffectiveness and Insulin Sensitivity. Diabetes. 1995; 44: 347-53.

Osawa, H., Printz, R.L., Whitesell, R.R. and Granner, D.K. Regulation of Hexokinase II Gene Transcription and Glucose Phosphorylation by Catecholamines, Cyclic AMP and Insulin in Muscle and Fat Cells. Diabetes. 1995; 44: 1426-32.

Ardehali, H., Printz, R.L., Koch, S., Phillips III, J.A. and Granner, D.K. Isolation, Characterization and Chromosomal Localization of a Human Pseudogene for Hexokinase II. Gene. 1995; 164: 357-61.

Mandarino, L.J., Printz, R.K., Cusi, K.A., Kinchington, P., O?Doherty, R.M., Osawa, H., Sewell, C., Consoli, A., Granner, D.K. and DeFronzo, R.A. Regulation of Hexokinase II and Glycogen Synthase mRNA, Protein, and Catalytic Activity in Human Skeletal Muscle In Vivo. Am. J. Physiol. 1995; E701-E708.

O'Brien, R.M., Printz, R.L., Halmi, N., Tiesinga, J.J. and Granner, D.K. Structural and Functional Analysis of the Human Phosphoenolpyruvate Carboxykinase Gene Promtoer. Biochem. et Biophys. Acta. 1995; 1264: 284-8.

O'Brien, R. M., Halmi, N., Stromstedt, P. E., Printz, R. L., Granner, D. K. Expression cloning of a zinc-finger cyclic AMP-response-element-binding protein. Biochem. J. 1995; 312: 17-21.

Postic, C., Leturque, A., Printz, R., Granner, D. and Girard, J. Development and Regulation of Glucose Transporter and Hexokinase Expression in Rat. Am. J. Physiol. 1994; 266: E548-E559.

Morita, H., Yano, Y., Niswender, K.D., May, J.M., Whitesell, R.R., Wu, L., Printz, R.L., Granner, D.K., Magnuson, M.A. and Powers, A.C. Co-expression of Glucose Transporters and Glucokinase in Xenopus Oocytes Indicates that Both Glucose Transport and Phosphorylation Determine Glucose Utilization. J. Clin. Investi. 1994; 94: 1373-82.

Printz RL, Magnuson MA, Granner DK. Mammalian glucokinase. Annu Rev Nutr. 1993; 13: 463-96.

Printz, R.L., Koch, S., Potter, L.R., O'Doherty, R.M., Tiesinga, J.J., Moritz, S. and Granner, D.K. Hexokinase II mRNA and Gene Structure, Regulation by Insulin and Evolution. J. Biol. Chem. 1993; 268: 5209-19.

Postic, C., Leturque A., Rencurel F., Printz, R.L., Forest, C., Granner, D.K. and Girard, J. The Effects of Hyperinsulinemia and Hyperglycemia on GLUT 4 and Hexokinase II mRNA and Protein in Rat Skeletal Muscle and Adipose Tissue. Diabetes. 1993; 42: 922-9.

Burchelin, R., Printz, R.L., Kande, J., Assan, R., Granner, D.K. and Girard, J. Regulation of Glucose Transporter and Hexokinase II mRNA in Adipose Tissue, Skeletal Muscle and Heart of Diabetic Rats. The Relative Roles of Hyperglycemia and Hypoinsulinemia. Am. J. Physiology. 1993; 265: E392-E401.

Printz RL. Protein, mRNA and gene for glucokinase and hexokinase II: primary structure and regulation by insulin. PhD Dissertation. 1992.

Chien CT, Tauler A, Lange AJ, Chan K, Printz RL, el MM, Granner DK, Pilkis SJ. Expression of rat hepatic glucokinase in Escherichia coli. Biochem Biophys Res Commun. 1989; 165: 817-25.

Magnuson MA, Andreone TL, Printz RL, Koch S, Granner DK. Rat glucokinase gene: structure and regulation by insulin. Proc Natl Acad Sci U S A. 1989; 4838-42: 86.

Andreone TL, Printz RL, Pilkis SJ, Magnuson MA, Granner DK. The amino acid sequence of rat liver glucokinase deduced from cloned cDNA. J Biol Chem. 1989; 264: 363-9.

Hardison RC, Printz R. Variability within the rabbit C repeats and sequences shared with other SINES. Nucleic Acids Res. 1985; 13: 1073-88.

Khatra BS, Printz R, Cobb CE, Corbin JD. Regulatory subunit of cAMP-dependent protein kinase inhibits phosphoprotein phosphatase. Biochem Biophys Res Commun. 1985; 130: 567-73.

Cheng JF, Printz R, Callaghan T, Shuey D, Hardison RC. The rabbit C family of short, interspersed repeats. Nucleotide sequence determination and transcriptional analysis. J Mol Biol. 1984; 176: 1-20.