James E. Loyd, M.D.

Professor

jim.loyd@vanderbilt.edu
Faculty Appointments
Professor of Medicine Rudy W. Jacobson Chair in Pulmonary Medicine
Education
M.D., West Virginia University, Morgantown, West VirginiaB.S., West Virginia University, Morgantown, West Virginia
Office Address
T-1219 MCN
TN 2650
Publications
Mathai SK, Pedersen BS, Smith K, Russell P, Schwarz MI, Brown KK, Steele MP, Loyd JE, Crapo JD, Silverman EK, Nickerson D, Fingerlin TE, Yang IV, Schwartz DA. Desmoplakin Variants Are Associated with Idiopathic Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. 2016 May 5/15/2016; 193(10): 1151-60. PMID: 26669357, PMCID: PMC4872666, DOI: 10.1164/rccm.201509-1863OC, ISSN: 1535-4970.

Mar PL, Nwazue V, Black BK, Biaggioni I, Diedrich A, Paranjape SY, Loyd JE, Hemnes AR, Robbins IM, Robertson D, Raj SR, Austin ED. Valsalva Maneuver in Pulmonary Arterial Hypertension: Susceptibility to Syncope and Autonomic Dysfunction. Chest [print-electronic]. 2016 May; 149(5): 1252-60. PMID: 26836906, PII: S0012-3692(15)00181-6, DOI: 10.1016/j.chest.2015.11.015, ISSN: 1931-3543.

Hemnes AR, Zhao M, West J, Newman JH, Rich S, Archer SL, Robbins IM, Blackwell TS, Cogan J, Loyd JE, Zhao Z, Gaskill C, Jetter C, Kropski JA, Majka SM, Austin ED. Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Feb 2/29/2016; PMID: 26926454, DOI: 10.1164/rccm.201508-1678OC, ISSN: 1535-4970.

Chen X, Talati M, Fessel JP, Hemnes AR, Gladson S, French J, Shay S, Trammell A, Phillips JA, Hamid R, Cogan JD, Dawson EP, Womble KE, Hedges LK, Martinez EG, Wheeler LA, Loyd JE, Majka SJ, West J, Austin ED. Estrogen Metabolite 16a-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism. Circulation [print-electronic]. 2016 Jan 1/5/2016; 133(1): 82-97. PMID: 26487756, PMCID: PMC4698046, PII: CIRCULATIONAHA.115.016133, DOI: 10.1161/CIRCULATIONAHA.115.016133, ISSN: 1524-4539.

Claar DD, Larkin EK, Bastarache L, Blackwell TS, Loyd JE, Hartert TV, Denny JC, Kropski JA. A Phenome-Wide Association Study Identifies a Novel Asthma Risk Locus Near TERC [letter]. Am. J. Respir. Crit. Care Med. 2016 Jan 1/1/2016; 193(1): 98-100. PMID: 26720789, PMCID: PMC4731616, DOI: 10.1164/rccm.201507-1267LE, ISSN: 1535-4970.

Fingerlin TE, Zhang W, Yang IV, Ainsworth HC, Russell PH, Blumhagen RZ, Schwarz MI, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch DA, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Maher TM, Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Murphy E, Smith K, McKean D, Pedersen BS, Talbert J, Powers J, Markin CR, Beckman KB, Lathrop M, Freed B, Langefeld CD, Schwartz DA. Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia. BMC Genet. 2016; 17(1): 74. PMID: 27266705, PMCID: PMC4895966, PII: 10.1186/s12863-016-0377-2, DOI: 10.1186/s12863-016-0377-2, ISSN: 1471-2156.

Machado RD, Southgate L, Eichstaedt CA, Aldred MA, Austin ED, Best DH, Chung WK, Benjamin N, Elliott CG, Eyries M, Fischer C, Gräf S, Hinderhofer K, Humbert M, Keiles SB, Loyd JE, Morrell NW, Newman JH, Soubrier F, Trembath RC, Viales RR, Grünig E. Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects. Hum. Mutat [print-electronic]. 2015 Dec; 36(12): 1113-27. PMID: 26387786, PMCID: PMC4822159, DOI: 10.1002/humu.22904, ISSN: 1098-1004.

Austin ED, Loyd JE. Toward Precision Medicine in Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med. 2015 Dec 12/1/2015; 192(11): 1272-4. PMID: 26623685, PMCID: PMC4731706, DOI: 10.1164/rccm.201508-1607ED, ISSN: 1535-4970.

Strock SB, Mason W, Loyd JE. Further Progress in Understanding Fibrosing Mediastinitis. Am. J. Respir. Crit. Care Med. 2015 Sep 9/15/2015; 192(6): 767-8. PMID: 26371817, PMCID: PMC4595681, DOI: 10.1164/rccm.201505-0964LE, ISSN: 1535-4970.

Mosley JD, Brittain EL, Loyd JE, Denny JC, Austin ED, Larkin EK. Letter by Mosley Regarding Article, "Iron Homeostasis and Pulmonary Hypertension: Iron Deficiency Leads to Pulmonary Vascular Remodeling in the Rat" [letter]. Circ. Res. 2015 Aug 8/28/2015; 117(6): e56-7. PMID: 26316607, PMCID: PMC4557206, PII: CIRCRESAHA.115.306867, DOI: 10.1161/CIRCRESAHA.115.306867, ISSN: 1524-4571.

Kropski JA, Loyd JE. Telomeres revisited: RTEL1 variants in pulmonary fibrosis [editorial]. Eur. Respir. J. 2015 Aug; 46(2): 312-4. PMID: 26232478, PII: 46/2/312, DOI: 10.1183/13993003.00710-2015, ISSN: 1399-3003.

Kropski JA, Blackwell TS, Loyd JE. The genetic basis of idiopathic pulmonary fibrosis. Eur. Respir. J [print-electronic]. 2015 Jun; 45(6): 1717-27. PMID: 25837031, PMCID: PMC4849867, PII: 09031936.00163814, DOI: 10.1183/09031936.00163814, ISSN: 1399-3003.

Kropski JA, Pritchett JM, Zoz DF, Crossno PF, Markin C, Garnett ET, Degryse AL, Mitchell DB, Polosukhin VV, Rickman OB, Choi L, Cheng DS, McConaha ME, Jones BR, Gleaves LA, McMahon FB, Worrell JA, Solus JF, Ware LB, Lee JW, Massion PP, Zaynagetdinov R, White ES, Kurtis JD, Johnson JE, Groshong SD, Lancaster LH, Young LR, Steele MP, Phillips Iii JA, Cogan JD, Loyd JE, Lawson WE, Blackwell TS. Extensive phenotyping of individuals at risk for familial interstitial pneumonia reveals clues to the pathogenesis of interstitial lung disease. Am. J. Respir. Crit. Care Med. 2015 Feb 2/15/2015; 191(4): 417-26. PMID: 25389906, PMCID: PMC4351594, DOI: 10.1164/rccm.201406-1162OC, ISSN: 1535-4970.

Strock SB, Gaudieri S, Mallal S, Yu C, Mitchell D, Cogan J, Mason W, Crowe D, Loyd JE. Fibrosing mediastinitis complicating prior histoplasmosis is associated with human leukocyte antigen DQB1*04:02 - a case control study. BMC Infect. Dis. 2015; 15: 206. PMID: 25940591, PMCID: PMC4424560, PII: 10.1186/s12879-015-0943-7, DOI: 10.1186/s12879-015-0943-7, ISSN: 1471-2334.

Shaver CM, Castilho JL, Cohen DN, Grogan EL, Miller GG, Dummer JS, Gray JN, Lambright ES, Loyd JE, Robbins IM. Fatal Scopulariopsis infection in a lung transplant recipient: lessons of organ procurement. Am. J. Transplant [print-electronic]. 2014 Dec; 14(12): 2893-7. PMID: 25376207, PMCID: PMC4263480, DOI: 10.1111/ajt.12940, ISSN: 1600-6143.

West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM. Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension. Am. J. Physiol., Cell Physiol [print-electronic]. 2014 Sep 9/1/2014; 307(5): C415-30. PMID: 24871858, PMCID: PMC4154073, PII: ajpcell.00057.2014, DOI: 10.1152/ajpcell.00057.2014, ISSN: 1522-1563.

Austin ED, Loyd JE. The genetics of pulmonary arterial hypertension. Circ. Res. 2014 Jun 6/20/2014; 115(1): 189-202. PMID: 24951767, PMCID: PMC4137413, PII: CIRCRESAHA.115.303404, DOI: 10.1161/CIRCRESAHA.115.303404, ISSN: 1524-4571.

Zhao M, Austin ED, Hemnes AR, Loyd JE, Zhao Z. An evidence-based knowledgebase of pulmonary arterial hypertension to identify genes and pathways relevant to pathogenesis. Mol Biosyst [print-electronic]. 2014 Apr; 10(4): 732-40. PMID: 24448676, PMCID: PMC3950334, DOI: 10.1039/c3mb70496c, ISSN: 1742-2051.

Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am. J. Respir. Crit. Care Med. 2014 Jan 1/15/2014; 189(2): 214-22. PMID: 24160862, PMCID: PMC3983890, DOI: 10.1164/rccm.201306-1141WS, ISSN: 1535-4970.

Soubrier F, Chung WK, Machado R, Grünig E, Aldred M, Geraci M, Loyd JE, Elliott CG, Trembath RC, Newman JH, Humbert M. Genetics and genomics of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 2013 Dec 12/24/2013; 62(25 Suppl): D13-21. PMID: 24355637, PII: S0735-1097(13)05878-6, DOI: 10.1016/j.jacc.2013.10.035, ISSN: 1558-3597.

Austin ED, Loyd JE. Heritable forms of pulmonary arterial hypertension. Semin Respir Crit Care Med [print-electronic]. 2013 Oct; 34(5): 568-80. PMID: 24037626, PMCID: PMC4102304, DOI: 10.1055/s-0033-1355443, ISSN: 1098-9048.

Brittain EL, Pugh ME, Wheeler LA, Robbins IM, Loyd JE, Newman JH, Larkin EK, Austin ED, Hemnes AR. Shorter survival in familial versus idiopathic pulmonary arterial hypertension is associated with hemodynamic markers of impaired right ventricular function. Pulm Circ [print-electronic]. 2013 Sep; 3(3): 589-98. PMID: 24618543, PMCID: PMC4070798, DOI: 10.1086/674326, ISSN: 2045-8932.

Fessel JP, Chen X, Frump A, Gladson S, Blackwell T, Kang C, Johnson J, Loyd JE, Hemnes A, Austin E, West J. Interaction between bone morphogenetic protein receptor type 2 and estrogenic compounds in pulmonary arterial hypertension. Pulm Circ [print-electronic]. 2013 Sep; 3(3): 564-77. PMID: 24618541, PMCID: PMC4070799, DOI: 10.1086/674312, ISSN: 2045-8932.

Richmond BW, Worrell JA, Bastarache JA, Gervich DH, Slattery WR, Loyd JE. Histoplasmomas of uncommon size. Chest. 2013 Jun; 143(6): 1795-8. PMID: 23732591, PII: S0012-3692(13)60414-6, DOI: 10.1378/chest.12-2071, ISSN: 1931-3543.

Kropski JA, Pritchett JM, Mason WR, Sivarajan L, Gleaves LA, Johnson JE, Lancaster LH, Lawson WE, Blackwell TS, Steele MP, Loyd JE, Rickman OB. Bronchoscopic cryobiopsy for the diagnosis of diffuse parenchymal lung disease. PLoS ONE. 2013; 8(11): e78674. PMID: 24265706, PMCID: PMC3827078, PII: PONE-D-13-31364, DOI: 10.1371/journal.pone.0078674, ISSN: 1932-6203.

Larkin EK, Newman JH, Austin ED, Hemnes AR, Wheeler L, Robbins IM, West JD, Phillips JA, Hamid R, Loyd JE. Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2012 Nov 11/1/2012; 186(9): 892-6. PMID: 22923661, PMCID: PMC3530218, PII: rccm.201205-0886OC, DOI: 10.1164/rccm.201205-0886OC, ISSN: 1535-4970.

Austin ED, Ma L, LeDuc C, Berman Rosenzweig E, Borczuk A, Phillips JA, Palomero T, Sumazin P, Kim HR, Talati MH, West J, Loyd JE, Chung WK. Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension. Circ Cardiovasc Genet [print-electronic]. 2012 Jun; 5(3): 336-43. PMID: 22474227, PMCID: PMC3380156, PII: CIRCGENETICS.111.961888, DOI: 10.1161/CIRCGENETICS.111.961888, ISSN: 1942-3268.

Polosukhin VV, Degryse AL, Newcomb DC, Jones BR, Ware LB, Lee JW, Loyd JE, Blackwell TS, Lawson WE. Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice. Exp. Lung Res. 2012 Apr; 38(3): 135-46. PMID: 22394287, PMCID: PMC4046254, DOI: 10.3109/01902148.2012.658595, ISSN: 1521-0499.

Austin ED, Hamid R, Hemnes AR, Loyd JE, Blackwell T, Yu C, Phillips Iii JA, Gaddipati R, Gladson S, Gu E, West J, Lane KB. BMPR2 expression is suppressed by signaling through the estrogen receptor. Biol Sex Differ. 2012; 3(1): 6. PMID: 22348410, PMCID: PMC3310853, PII: 2042-6410-3-6, DOI: 10.1186/2042-6410-3-6, ISSN: 2042-6410.

Austin ED, Menon S, Hemnes AR, Robinson LR, Talati M, Fox KL, Cogan JD, Hamid R, Hedges LK, Robbins I, Lane K, Newman JH, Loyd JE, West J. Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression. Pulm Circ. 2011 Jul; 1(3): 389-98. PMID: 22140629, PMCID: PMC3224431, PII: PC-1-389, DOI: 10.4103/2045-8932.87308, ISSN: 2045-8940.

Fessel JP, Loyd JE, Austin ED. The genetics of pulmonary arterial hypertension in the post-BMPR2 era. Pulm Circ. 2011 Jul; 1(3): 305-19. PMID: 22140620, PMCID: PMC3224422, PII: PC-1-305, DOI: 10.4103/2045-8932.87293, ISSN: 2045-8940.

Lawson WE, Loyd JE, Degryse AL. Genetics in pulmonary fibrosis--familial cases provide clues to the pathogenesis of idiopathic pulmonary fibrosis. Am. J. Med. Sci. 2011 Jun; 341(6): 439-43. PMID: 21613931, PMCID: PMC3103077, PII: 00000441-201106000-00005, DOI: 10.1097/MAJ.0b013e31821a9d7a, ISSN: 1538-2990.

Loyd JE. Pulmonary arterial hypertension: insights from genetic studies. Proc Am Thorac Soc. 2011 May; 8(2): 154-7. PMID: 21543793, PMCID: PMC3131832, PII: 8/2/154, DOI: 10.1513/pats.201007-047MS, ISSN: 1943-5665.

Albers EL, Pugh ME, Hill KD, Wang L, Loyd JE, Doyle TP. Percutaneous vascular stent implantation as treatment for central vascular obstruction due to fibrosing mediastinitis. Circulation [print-electronic]. 2011 Apr 4/5/2011; 123(13): 1391-9. PMID: 21422386, PMCID: PMC3095436, PII: CIRCULATIONAHA.110.949180, DOI: 10.1161/CIRCULATIONAHA.110.949180, ISSN: 1524-4539.

Majka S, Hagen M, Blackwell T, Harral J, Johnson JA, Gendron R, Paradis H, Crona D, Loyd JE, Nozik-Grayck E, Stenmark KR, West J. Physiologic and molecular consequences of endothelial Bmpr2 mutation. Respir. Res. 2011; 12: 84. PMID: 21696628, PMCID: PMC3141420, PII: 1465-9921-12-84, DOI: 10.1186/1465-9921-12-84, ISSN: 1465-993X.

Johnson JA, Loyd JE, Wheat LJ, Netterville JL. A case series and review of histoplasmosis infection in the neck. Arch. Otolaryngol. Head Neck Surg. 2010 Sep; 136(9): 916-9. PMID: 20855687, PII: 136/9/916, DOI: 10.1001/archoto.2010.143, ISSN: 1538-361X.

Talati M, West J, Blackwell TR, Loyd JE, Meyrick B. BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2010 Sep; 299(3): L363-73. PMID: 20562228, PMCID: PMC2951074, PII: ajplung.00295.2009, DOI: 10.1152/ajplung.00295.2009, ISSN: 1522-1504.

Crossno PF, Polosukhin VV, Blackwell TS, Johnson JE, Markin C, Moore PE, Worrell JA, Stahlman MT, Phillips JA, Loyd JE, Cogan JD, Lawson WE. Identification of early interstitial lung disease in an individual with genetic variations in ABCA3 and SFTPC. Chest. 2010 Apr; 137(4): 969-73. PMID: 20371530, PMCID: PMC2851554, PII: 137/4/969, DOI: 10.1378/chest.09-0790, ISSN: 1931-3543.

Hamid R, Hedges LK, Austin E, Phillips JA, Loyd JE, Cogan JD. Transcripts from a novel BMPR2 termination mutation escape nonsense mediated decay by downstream translation re-initiation: implications for treating pulmonary hypertension. Clin. Genet [print-electronic]. 2010 Mar; 77(3): 280-6. PMID: 20095988, PMCID: PMC3741656, PII: CGE1311, DOI: 10.1111/j.1399-0004.2009.01311.x, ISSN: 1399-0004.

Austin ED, Rock MT, Mosse CA, Vnencak-Jones CL, Yoder SM, Robbins IM, Loyd JE, Meyrick BO. T lymphocyte subset abnormalities in the blood and lung in pulmonary arterial hypertension. Respir Med [print-electronic]. 2010 Mar; 104(3): 454-62. PMID: 19880300, PMCID: PMC2826574, PII: S0954-6111(09)00325-4, DOI: 10.1016/j.rmed.2009.10.004, ISSN: 1532-3064.

Austin ED, Cogan JD, West JD, Hedges LK, Hamid R, Dawson EP, Wheeler LA, Parl FF, Loyd JE, Phillips JA. Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females. Eur. Respir. J [print-electronic]. 2009 Nov; 34(5): 1093-9. PMID: 19357154, PMCID: PMC3742124, PII: 09031936.00010409, DOI: 10.1183/09031936.00010409, ISSN: 1399-3003.

Lancaster LH, Mason WR, Parnell JA, Rice TW, Loyd JE, Milstone AP, Collard HR, Malow BA. Obstructive sleep apnea is common in idiopathic pulmonary fibrosis. Chest [print-electronic]. 2009 Sep; 136(3): 772-8. PMID: 19567497, PMCID: PMC2775994, PII: chest.08-2776, DOI: 10.1378/chest.08-2776, ISSN: 1931-3543.

Austin ED, Loyd JE, Phillips JA. Genetics of pulmonary arterial hypertension. Semin Respir Crit Care Med [print-electronic]. 2009 Aug; 30(4): 386-98. PMID: 19634078, PMCID: PMC3737593, DOI: 10.1055/s-0029-1233308, ISSN: 1098-9048.

Thomas LD, Milstone AP, Miller GG, Loyd JE, Stephen Dummer J. Long-term outcomes of cytomegalovirus infection and disease after lung or heart-lung transplantation with a delayed ganciclovir regimen. Clin Transplant [print-electronic]. 2009 Aug; 23(4): 476-83. PMID: 19453645, PII: CTR990, DOI: 10.1111/j.1399-0012.2009.00990.x, ISSN: 1399-0012.

Hamid R, Cogan JD, Hedges LK, Austin E, Phillips JA, Newman JH, Loyd JE. Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele. Hum. Mutat. 2009 Apr; 30(4): 649-54. PMID: 19206171, PMCID: PMC2663001, DOI: 10.1002/humu.20922, ISSN: 1098-1004.

Austin ED, Phillips JA, Cogan JD, Hamid R, Yu C, Stanton KC, Phillips CA, Wheeler LA, Robbins IM, Newman JH, Loyd JE. Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension. Respir. Res. 2009; 10: 87. PMID: 19785764, PMCID: PMC2762975, PII: 1465-9921-10-87, DOI: 10.1186/1465-9921-10-87, ISSN: 1465-993X.

Johnson JA, Vnencak-Jones CL, Cogan JD, Loyd JE, West J. Copy-number variation in BMPR2 is not associated with the pathogenesis of pulmonary arterial hypertension. BMC Med. Genet. 2009; 10: 58. PMID: 19531247, PMCID: PMC2706815, PII: 1471-2350-10-58, DOI: 10.1186/1471-2350-10-58, ISSN: 1471-2350.

Crossno PF, Loyd JE, Milstone AP. External-beam radiotherapy for massive hemoptysis complicating mediastinal fibrosis. South. Med. J. 2008 Oct; 101(10): 1056-8. PMID: 18791523, DOI: 10.1097/SMJ.0b013e31817e9dad, ISSN: 1541-8243.

Lawson WE, Crossno PF, Polosukhin VV, Roldan J, Cheng DS, Lane KB, Blackwell TR, Xu C, Markin C, Ware LB, Miller GG, Loyd JE, Blackwell TS. Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2008 Jun; 294(6): L1119-26. PMID: 18390830, PII: 00382.2007, DOI: 10.1152/ajplung.00382.2007, ISSN: 1040-0605.

Phillips JA, Poling JS, Phillips CA, Stanton KC, Austin ED, Cogan JD, Wheeler L, Yu C, Newman JH, Dietz HC, Loyd JE. Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension. Genet. Med. 2008 May; 10(5): 359-65. PMID: 18496036, PII: 00125817-200805000-00010, DOI: 10.1097/GIM.0b013e318172dcdf, ISSN: 1530-0366.

Newman JH, Phillips JA, Loyd JE. Narrative review: the enigma of pulmonary arterial hypertension: new insights from genetic studies. Ann. Intern. Med. 2008 Feb 2/19/2008; 148(4): 278-83. PMID: 18283205, PII: 148/4/278, ISSN: 1539-3704.

Meyrick BO, Friedman DB, Billheimer DD, Cogan JD, Prince MA, Phillips JA, Loyd JE. Proteomics of transformed lymphocytes from a family with familial pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2008 Jan 1/1/2008; 177(1): 99-107. PMID: 17932379, PMCID: PMC2176118, PII: 200703-499OC, DOI: 10.1164/rccm.200703-499OC, ISSN: 1535-4970.

Worrell JA, Donnelly EF, Martin JB, Bastarache JA, Loyd JE. Computed tomography and the idiopathic form of proliferative fibrosing mediastinitis. J Thorac Imaging. 2007 Aug; 22(3): 235-40. PMID: 17721332, PII: 00005382-200708000-00004, DOI: 10.1097/01.rti.0000213589.29472.18, ISSN: 0883-5993.

Johnson RF, Loyd JE, Mullican AL, Fink CA, Robbins IM. Long-term follow-up after conversion from intravenous epoprostenol to oral therapy with bosentan or sildenafil in 13 patients with pulmonary arterial hypertension. J. Heart Lung Transplant [print-electronic]. 2007 Apr; 26(4): 363-9. PMID: 17403478, PII: S1053-2498(07)00041-1, DOI: 10.1016/j.healun.2007.01.022, ISSN: 1557-3117.

Austin ED, Loyd JE. Genetics and mediators in pulmonary arterial hypertension. Clin. Chest Med. 2007 Mar; 28(1): 43-57, vii. PMID: 17338927, PMCID: PMC3740514, PII: S0272-5231(06)00121-3, DOI: 10.1016/j.ccm.2006.11.007, ISSN: 0272-5231.

Cogan JD, Pauciulo MW, Batchman AP, Prince MA, Robbins IM, Hedges LK, Stanton KC, Wheeler LA, Phillips JA, Loyd JE, Nichols WC. High frequency of BMPR2 exonic deletions/duplications in familial pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2006 Sep 9/1/2006; 174(5): 590-8. PMID: 16728714, PMCID: PMC2648061, PII: 200602-165OC, DOI: 10.1164/rccm.200602-165OC, ISSN: 1073-449X.

Milstone AP, Brumble LM, Barnes J, Estes W, Loyd JE, Pierson RN, Dummer S. A single-season prospective study of respiratory viral infections in lung transplant recipients. Eur. Respir. J [print-electronic]. 2006 Jul; 28(1): 131-7. PMID: 16510454, PII: 09031936.06.00105505, DOI: 10.1183/09031936.06.00105505, ISSN: 0903-1936.

Lawson WE, Loyd JE. The genetic approach in pulmonary fibrosis: can it provide clues to this complex disease?. Proc Am Thorac Soc. 2006 Jun; 3(4): 345-9. PMID: 16738199, PMCID: PMC2658686, PII: 3/4/345, DOI: 10.1513/pats.200512-137TK, ISSN: 1546-3222.

Willers ED, Newman JH, Loyd JE, Robbins IM, Wheeler LA, Prince MA, Stanton KC, Cogan JA, Runo JR, Byrne D, Humbert M, Simonneau G, Sztrymf B, Morse JA, Knowles JA, Roberts KE, McElroy JJ, Barst RJ, Phillips JA. Serotonin transporter polymorphisms in familial and idiopathic pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2006 Apr 4/1/2006; 173(7): 798-802. PMID: 16339917, PMCID: PMC2662954, PII: 200509-1361OC, DOI: 10.1164/rccm.200509-1361OC, ISSN: 1073-449X.

Lane KB, Blackwell TR, Runo J, Wheeler L, Phillips JA, Loyd JE. Aberrant signal transduction in pulmonary hypertension. Chest. 2005 Dec; 128(6 Suppl): 564S-565S. PMID: 16373826, PII: S0012-3692(15)30984-3, DOI: 10.1378/chest.128.6_suppl.564S-a, ISSN: 0012-3692.

Lawson WE, Polosukhin VV, Zoia O, Stathopoulos GT, Han W, Plieth D, Loyd JE, Neilson EG, Blackwell TS. Characterization of fibroblast-specific protein 1 in pulmonary fibrosis. Am. J. Respir. Crit. Care Med [print-electronic]. 2005 Apr 4/15/2005; 171(8): 899-907. PMID: 15618458, PII: 200311-1535OC, DOI: 10.1164/rccm.200311-1535OC, ISSN: 1073-449X.

Cogan JD, Vnencak-Jones CL, Phillips JA, Lane KB, Wheeler LA, Robbins IM, Garrison G, Hedges LK, Loyd JE. Gross BMPR2 gene rearrangements constitute a new cause for primary pulmonary hypertension. Genet. Med. 2005 Mar; 7(3): 169-74. PMID: 15775752, PII: 00125817-200503000-00003, DOI: 10.109701.GIM.0000156525.09595.E9, ISSN: 1098-3600.

Lawson WE, Grant SW, Ambrosini V, Womble KE, Dawson EP, Lane KB, Markin C, Renzoni E, Lympany P, Thomas AQ, Roldan J, Scott TA, Blackwell TS, Phillips JA, Loyd JE, du Bois RM. Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF. Thorax. 2004 Nov; 59(11): 977-80. PMID: 15516475, PMCID: PMC1746860, PII: 59/11/977, DOI: 10.1136/thx.2004.026336, ISSN: 0040-6376.

Newman JH, Fanburg BL, Archer SL, Badesch DB, Barst RJ, Garcia JG, Kao PN, Knowles JA, Loyd JE, McGoon MD, Morse JH, Nichols WC, Rabinovitch M, Rodman DM, Stevens T, Tuder RM, Voelkel NF, Gail DB, . Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop. Circulation. 2004 Jun 6/22/2004; 109(24): 2947-52. PMID: 15210611, PII: 109/24/2947, DOI: 10.1161/01.CIR.0000132476.87231.6F, ISSN: 1524-4539.

Newman JH, Trembath RC, Morse JA, Grunig E, Loyd JE, Adnot S, Coccolo F, Ventura C, Phillips JA, Knowles JA, Janssen B, Eickelberg O, Eddahibi S, Herve P, Nichols WC, Elliott G. Genetic basis of pulmonary arterial hypertension: current understanding and future directions. J. Am. Coll. Cardiol. 2004 Jun 6/16/2004; 43(12 Suppl S): 33S-39S. PMID: 15194176, PII: S0735109704004371, DOI: 10.1016/j.jacc.2004.02.028, ISSN: 0735-1097.

Loyd JE. Pulmonary fibrosis in families. Am. J. Respir. Cell Mol. Biol. 2003 Sep; 29(3 Suppl): S47-50. PMID: 14503554, ISSN: 1044-1549.

Schröder C, Scholl F, Daon E, Goodwin A, Frist WH, Roberts JR, Christian KG, Ninan M, Milstone AP, Loyd JE, Merrill WH, Pierson RN. A modified bronchial anastomosis technique for lung transplantation. Ann. Thorac. Surg. 2003 Jun; 75(6): 1697-704. PMID: 12822602, ISSN: 0003-4975.

Tang YW, Johnson JE, Browning PJ, Cruz-Gervis RA, Davis A, Graham BS, Brigham KL, Oates JA, Loyd JE, Stecenko AA. Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis. J. Clin. Microbiol. 2003 Jun; 41(6): 2633-40. PMID: 12791891, PMCID: PMC156536, ISSN: 0095-1137.

Runo JR, Loyd JE. Primary pulmonary hypertension. Lancet. 2003 May 5/3/2003; 361(9368): 1533-44. PMID: 12737878, PII: S0140-6736(03)13167-4, DOI: 10.1016/S0140-6736(03)13167-4, ISSN: 0140-6736.

Runo JR, Vnencak-Jones CL, Prince M, Loyd JE, Wheeler L, Robbins IM, Lane KB, Newman JH, Johnson J, Nichols WC, Phillips JA. Pulmonary veno-occlusive disease caused by an inherited mutation in bone morphogenetic protein receptor II. Am. J. Respir. Crit. Care Med [print-electronic]. 2003 Mar 3/15/2003; 167(6): 889-94. PMID: 12446270, PII: 200208-861OC, DOI: 10.1164/rccm.200208-861OC, ISSN: 1073-449X.

Kuhn KP, Byrne DW, Arbogast PG, Doyle TP, Loyd JE, Robbins IM. Outcome in 91 consecutive patients with pulmonary arterial hypertension receiving epoprostenol. Am. J. Respir. Crit. Care Med [print-electronic]. 2003 Feb 2/15/2003; 167(4): 580-6. PMID: 12446266, PII: 200204-333OC, DOI: 10.1164/rccm.200204-333OC, ISSN: 1073-449X.

Loyd JE. Genetics and pulmonary hypertension. Chest. 2002 Dec; 122(6 Suppl): 284S-286S. PMID: 12475800, PII: S0012-3692(15)32965-2, ISSN: 0012-3692.

Pierson RN, Loyd JE, Goodwin A, Majors D, Dummer JS, Mohacsi P, Wheeler A, Bovin N, Miller GG, Olson S, Johnson J, Rieben R, Azimzadeh A. Successful management of an ABO-mismatched lung allograft using antigen-specific immunoadsorption, complement inhibition, and immunomodulatory therapy. Transplantation. 2002 Jul 7/15/2002; 74(1): 79-84. PMID: 12134103, ISSN: 0041-1337.

Thomas AQ, Lane K, Phillips J, Prince M, Markin C, Speer M, Schwartz DA, Gaddipati R, Marney A, Johnson J, Roberts R, Haines J, Stahlman M, Loyd JE. Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred. Am. J. Respir. Crit. Care Med. 2002 May 5/1/2002; 165(9): 1322-8. PMID: 11991887, DOI: 10.1164/rccm.200112-123OC, ISSN: 1073-449X.

Thomas AQ, Carneal J, Markin C, Lane KB, Phillips JA, Loyd JE, Gaddipati R. Specific bone morphogenic protein receptor II mutations found in primary pulmonary hypertension cause different biochemical phenotypes in vitro. Chest. 2002 Mar; 121(3 Suppl): 83S. PMID: 11893707, PII: S0012-3692(15)35486-6, ISSN: 0012-3692.

Loyd JE. Parker B. Francis Lecture. Genetics and gene expression in pulmonary hypertension. Chest. 2002 Mar; 121(3 Suppl): 46S-50S. PMID: 11893683, PII: S0012-3692(15)35462-3, ISSN: 0012-3692.

Thomas AQ, Carneal J, Markin C, Lane KB, Phillips JA, Loyd JE. Allelic imbalance demonstrated by microsatellite analysis of lung samples from patients with familial pulmonary fibrosis. Chest. 2002 Mar; 121(3 Suppl): 25S. PMID: 11893660, PII: S0012-3692(15)35439-8, ISSN: 0012-3692.

Cruz-Gervis R, Stecenko AA, Dworski R, Lane KB, Loyd JE, Pierson R, King G, Brigham KL. Altered prostanoid production by fibroblasts cultured from the lungs of human subjects with idiopathic pulmonary fibrosis. Respir. Res [print-electronic]. 2002; 3: 17. PMID: 11980586, PMCID: PMC107846, ISSN: 1465-993X.

Thomas AQ, Gaddipati R, Newman JH, Loyd JE. Genetics of primary pulmonary hypertension. Clin. Chest Med. 2001 Sep; 22(3): 477-91, ix. PMID: 11590842, ISSN: 0272-5231.

Doyle TP, Loyd JE, Robbins IM. Percutaneous pulmonary artery and vein stenting: a novel treatment for mediastinal fibrosis. Am. J. Respir. Crit. Care Med. 2001 Aug 8/15/2001; 164(4): 657-60. PMID: 11520733, DOI: 10.1164/ajrccm.164.4.2012132, ISSN: 1073-449X.

Newman JH, Wheeler L, Lane KB, Loyd E, Gaddipati R, Phillips JA, Loyd JE. Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred. N. Engl. J. Med. 2001 Aug 8/2/2001; 345(5): 319-24. PMID: 11484688, DOI: 10.1056/NEJM200108023450502, ISSN: 0028-4793.

Marney A, Lane KB, Phillips JA, Riley DJ, Loyd JE. Idiopathic pulmonary fibrosis can be an autosomal dominant trait in some families. Chest. 2001 Jul; 120(1 Suppl): 56S. PMID: 11451917, ISSN: 0012-3692.

Davis AM, Pierson RN, Loyd JE. Mediastinal fibrosis. Semin Respir Infect. 2001 Jun; 16(2): 119-30. PMID: 11521244, PII: S0882054601000184, ISSN: 0882-0546.

Holcomb BW, Loyd JE, Byrd BF, Wilsdorf TT, Casey-Cato T, Mason WR, Robbins IM. Iatrogenic paradoxical air embolism in pulmonary hypertension. Chest. 2001 May; 119(5): 1602-5. PMID: 11348976, PII: S0012-3692(15)39629-X, ISSN: 0012-3692.

Holcomb BW, Loyd JE, Ely EW, Johnson J, Robbins IM. Pulmonary veno-occlusive disease: a case series and new observations. Chest. 2000 Dec; 118(6): 1671-9. PMID: 11115457, PII: S0012-3692(15)37877-6, ISSN: 0012-3692.

Pierson RN, Milstone AP, Loyd JE, Lewis BH, Pinson CW, Ely EW. Lung allocation in the United States, 1995-1997: an analysis of equity and utility. J. Heart Lung Transplant. 2000 Sep; 19(9): 846-51. PMID: 11008073, PII: S1053-2498(00)00151-0, ISSN: 1053-2498.

, Lane KB, Machado RD, Pauciulo MW, Thomson JR, Phillips JA, Loyd JE, Nichols WC, Trembath RC. Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. Nat. Genet. 2000 Sep; 26(1): 81-4. PMID: 10973254, DOI: 10.1038/79226, ISSN: 1061-4036.

Milstone AP, Brumble LM, Loyd JE, Ely EW, Roberts JR, Pierson RN, Dummer JS. Active CMV infection before lung transplantation: risk factors and clinical implications. J. Heart Lung Transplant. 2000 Aug; 19(8): 744-50. PMID: 10967267, PII: S1053-2498(00)00134-0, ISSN: 1053-2498.

Peebles RS, Carpenter CT, Dupont WD, Loyd JE. Mediastinal fibrosis is associated with human leukocyte antigen-A2. Chest. 2000 Feb; 117(2): 482-5. PMID: 10669694, PII: S0012-3692(15)48641-6, ISSN: 0012-3692.

Sadikot RT, Johnson J, Loyd JE, Christman JW. Respiratory bronchiolitis associated with severe dyspnea, exertional hypoxemia, and clubbing. Chest. 2000 Jan; 117(1): 282-5. PMID: 10631233, PII: S0012-3692(15)30963-6, ISSN: 0012-3692.

Robbins IM, Gaine SP, Schilz R, Tapson VF, Rubin LJ, Loyd JE. Epoprostenol for treatment of pulmonary hypertension in patients with systemic lupus erythematosus. Chest. 2000 Jan; 117(1): 14-8. PMID: 10631192, PII: S0012-3692(15)30922-3, ISSN: 0012-3692.

Friedli JL, Paschal CB, Loyd JE, Halliburton SS. Quantitative 3D VUSE pulmonary MRA. Magn Reson Imaging. 1999 Apr; 17(3): 363-70. PMID: 10195579, PII: S0730725X98001775, ISSN: 0730-725X.

Robbins IM, Christman BW, Newman JH, Matlock R, Loyd JE. A survey of diagnostic practices and the use of epoprostenol in patients with primary pulmonary hypertension. Chest. 1998 Nov; 114(5): 1269-75. PMID: 9824000, PII: S0012-3692(16)33059-8, ISSN: 0012-3692.

Robbins IM, Colvin EV, Doyle TP, Kemp WE, Loyd JE, McMahon WS, Kay GN. Pulmonary vein stenosis after catheter ablation of atrial fibrillation. Circulation. 1998 Oct 10/27/1998; 98(17): 1769-75. PMID: 9788832, ISSN: 0009-7322.

Slovis BS, Chazova I, Loyd JE, Meyrick BO. Pulmonary capillary haemangiomatosis coexistence with sinus venosus ASD: morphometric analysis and literature review. Eur. Respir. J. 1998 Jul; 12(1): 240-4. PMID: 9701445, ISSN: 0903-1936.

Loyd JE, Slovis B, Phillips JA, Butler MG, Foroud TM, Conneally PM, Newman JH. The presence of genetic anticipation suggests that the molecular basis of familial primary pulmonary hypertension may be trinucleotide repeat expansion. Chest. 1997 Jun; 111(6 Suppl): 82S-83S. PMID: 9184540, PII: S0012-3692(15)47128-4, ISSN: 0012-3692.

McGee C, Fox MD, Loyd JE. The feasibility of HLA matching for lung transplantation. Clin Transplant. 1996 Dec; 10(6 Pt 1): 564-7. PMID: 8996780, ISSN: 0902-0063.

Frist WH, Lorenz CH, Walker ES, Loyd JE, Stewart JR, Graham TP, Pearlstein DP, Key SP, Merrill WH. MRI complements standard assessment of right ventricular function after lung transplantation. Ann. Thorac. Surg. 1995 Aug; 60(2): 268-71. PMID: 7646085, PII: 000349759500365R, ISSN: 0003-4975.

Loyd JE, Butler MG, Foroud TM, Conneally PM, Phillips JA, Newman JH. Genetic anticipation and abnormal gender ratio at birth in familial primary pulmonary hypertension. Am. J. Respir. Crit. Care Med. 1995 Jul; 152(1): 93-7. PMID: 7599869, DOI: 10.1164/ajrccm.152.1.7599869, ISSN: 1073-449X.

Neuzil KM, Mitchell HC, Loyd JE, Lagerstrom CF, Hammon JW, Graham BS. Extrapulmonary thoracic disease caused by Blastomyces dermatitidis. Chest. 1994 Dec; 106(6): 1885-7. PMID: 7988217, PII: S0012-3692(15)44446-0, ISSN: 0012-3692.

Frist WH, Loyd JE, Merrill WH, Stewart JR, Dummer JS, Hoff SJ, Walker B, Bender HW. Single lung transplantation: a temporal look at rejection, infection, and survival. Am Surg. 1994 Feb; 60(2): 94-102. PMID: 8304652, ISSN: 0003-1348.

Wickersham NE, Loyd JE, Johnson JE, McCain RW, Christman JW. Acute inflammation in a sheep model of unilateral lung ischemia: the role of interleukin-8 recruitment of polymorphonuclear leukocytes. Am. J. Respir. Cell Mol. Biol. 1993 Aug; 9(2): 199-204. PMID: 8338687, ISSN: 1044-1549.

Frist WH, Carmichael LC, Loyd JE, Merrill WH, Stewart JR, Biggs VJ, Bender HW. Transplantation for pulmonary hypertension. Transplant. Proc. 1993 Feb; 25(1 Pt 2): 1159-61. PMID: 8442071, ISSN: 0041-1345.

Gilroy RJ, Bhatte MJ, Wickersham NE, Pou NA, Loyd JE, Overholser KA. Postischemic hypoperfusion during unilateral lung reperfusion in vivo. Am. Rev. Respir. Dis. 1993 Feb; 147(2): 276-82. PMID: 8430948, DOI: 10.1164/ajrccm/147.2.276, ISSN: 0003-0805.