Nancy J. Brown, M.D.

Professor

nancy.j.brown@vanderbilt.edu
Faculty Appointments
Chair of the Department of Medicine Professor of Medicine Professor of PharmacologyHugh J. Morgan Chair in Medicine
Education
M.D., Medicine, Harvard Medical School, Boston, MassachusettsB.A., Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut
Office Address
D-3100 Medical Center North
Vanderbilt University Medical Center
Nashville, TN
Research Description
Research in our laboratory focuses on the following areas:
1. Role of the renin-angiotensin-aldosterone system in modulating oxidative stress, inflammation and fibrinolysis.
The renin-angiotensin-aldosterone system (RAAS) is one of the major blood pressure regulating systems in the body. The small peptide angiotensin II, Ang II, raises blood pressure by constricting blood vessels and increasing salt retention, in part by stimulating synthesis of the mineralocorticoid aldosterone. We now understand that the RAAS has other detrimental effects on the blood vessels, heart and kidney. Both Ang II and aldosterone cause inflammation and fibrosis and promote clotting. Studies in our laboratory are examining the mechanisms of these effects.

2. Role of the renin-angiotensin-aldosterone system in regulating glucose homeostasis.
Sixty per cent of Americans are obese and both the activity of the RAAS and inflammation are increased in obesity. Obese individuals are at increased risk for the development of diabetes and hypertension, but drugs that interrupt the RAAS seem to decrease this risk. Studies in our laboratory are helping us to understand the mechanism for this effect so that we may devise better strategies to prevent diabetes.

3. Cardiovascular effects of the kallikrein-kinin system.
Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are the two major classes of drugs currently used to interrupt the renin-angiotensin-aldosterone system. ACE inhibitors decrease the formation of Ang II, whereas ARBs block the effect of Ang II at its major receptor. In addition, ACE inhibitors prevent the breakdown of and promote the actions of bradykinin, a peptide in the body that lowers blood pressure. Bradykinin has other beneficial effects, like increasing tissue-type plasminogen activator from the endothelium. Bradykinin can also have detrimental effects, promoting inflammation. The net beneficial or detrimental effect of bradykinin may depend on the health of the blood vessels.

4. Role of arachidonic acid monooxygenases and epoxygenases in the regulation of blood pressure and cardiovascular risk.
Bradykinin exerts its blood pressure lowering effects, in part, through effects on cytochrome P450 (CYP450) epoxygenases that form eicosatetraenoic acids (EETs) from arachidonic acid. EETs relax blood vessels. EETs formed in the kidney also stimulate salt excretion. Animal studies suggest that, in the kidney, EET formation is regulated in part by 20-hydroxyeicosatetraenoic acid 20-HETE, the product of CYP4A11. Research in our laboratory indicates that a loss-of-function variant of the gene encoding CYP4A11 is associated with high blood pressure and progression of renal disease. We are refining our understanding of how these systems regulate blood pressure in humans and how they interact with the RAAS.

5. Contribution of peptidases to angiotensin-converting enzyme (ACE) inhibitor-associated angioedema.
Despite the many beneficial effects of ACE inhibitors, this class of medications can cause swelling of the lips, tongue, or face, a side effect called angioedema. Likely, this side effect results from decreased breakdown of bradykinin and another peptide called substance P. We have determined groups of patients who are at increased risk for angioedema. Studies in our laboratory have identified one pathway involved in angioedema and will allow us to better predict risk and prevent the side effect.

6. Pharmacogenetics of the renin-angiotensin-aldosterone and kallikrein-kinin sytems.
Genetic factors modulate all of the processes described above. One goal of our laboratory is to identify these factors in order to better predict individual responses to drugs such as ACE inhibitors, ARBs, aldosterone receptor blockers and renin inhibitors.
Clinical Research Keywords
hypertension, renin-angiotensin-aldosterone, kallikrein-kinin, angiotensin-converting enzyme inhibitors, angioedema, fibrinolysis, inflammation, atrial fibrillation
Publications
Sharma A, Bhatt DL, Calvo G, Brown NJ, Zannad F, Mentz RJ. Heart failure event definitions in drug trials in patients with type 2 diabetes. Lancet Diabetes Endocrinol. 2016 Apr; 4(4): 294-6. PMID: 27016320, PII: S2213-8587(16)00049-8, DOI: 10.1016/S2213-8587(16)00049-8, ISSN: 2213-8595.

Gamboa JL, Devin JK, Ramirez CE, Yu C, Nian H, Lee RH, Brown NJ. Comparative effects of immediate-release and extended-release aspirin on basal and bradykinin-stimulated excretion of thromboxane and prostacyclin metabolites. Pharmacol Res Perspect. 2016 Apr; 4(2): e00221. PMID: 27069632, PMCID: PMC4804312, PII: PRP2221, DOI: 10.1002/prp2.221, ISSN: 2052-1707.

Semler MW, Marney AM, Rice TW, Nian H, Yu C, Wheeler AP, Brown NJ, . B-type Natriuretic Peptide, Aldosterone, and Fluid Management in Acute Respiratory Distress Syndrome. Chest [print-electronic]. 2016 Mar 3/23/2016; PMID: 27018313, PII: S0012-3692(16)45714-4, DOI: 10.1016/j.chest.2016.03.017, ISSN: 1931-3543.

Hubers SA, Brown NJ. Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition. Circulation. 2016 Mar 3/15/2016; 133(11): 1115-24. PMID: 26976916, PII: CIRCULATIONAHA.115.018622, DOI: 10.1161/CIRCULATIONAHA.115.018622, ISSN: 1524-4539.

Billings FT, Hendricks PA, Schildcrout JS, Shi Y, Petracek MR, Byrne JG, Brown NJ. High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial. JAMA. 2016 Mar 3/1/2016; 315(9): 877-88. PMID: 26906014, PII: 2492851, DOI: 10.1001/jama.2016.0548, ISSN: 1538-3598.

Ramirez CE, Nian H, Yu C, Gamboa JL, Luther JM, Brown NJ, Shibao CA. Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial. J. Clin. Endocrinol. Metab [print-electronic]. 2015 Dec; 100(12): 4533-40. PMID: 26580240, PMCID: PMC4667163, DOI: 10.1210/jc.2015-3415, ISSN: 1945-7197.

Wu JH, Marchioli R, Silletta MG, Masson S, Sellke FW, Libby P, Milne GL, Brown NJ, Lombardi F, Damiano RJ, Marsala J, Rinaldi M, Domenech A, Simon C, Tavazzi L, Mozaffarian D. Oxidative Stress Biomarkers and Incidence of Postoperative Atrial Fibrillation in the Omega-3 Fatty Acids for Prevention of Postoperative Atrial Fibrillation (OPERA) Trial. J Am Heart Assoc. 2015 May; 4(5): PMID: 25994442, PMCID: PMC4599415, PII: JAHA.115.001886, DOI: 10.1161/JAHA.115.001886, ISSN: 2047-9980.

Gamboa JL, Pretorius M, Sprinkel KC, Brown NJ, Ikizler TA. Angiotensin converting enzyme inhibition increases ADMA concentration in patients on maintenance hemodialysis--a randomized cross-over study. BMC Nephrol. 2015; 16: 167. PMID: 26494370, PMCID: PMC4618919, PII: 10.1186/s12882-015-0162-x, DOI: 10.1186/s12882-015-0162-x, ISSN: 1471-2369.

White MJ, Kodaman NM, Harder RH, Asselbergs FW, Vaughan DE, Brown NJ, Moore JH, Williams SM. Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population. PLoS ONE. 2015; 10(8): e0136379. PMID: 26322636, PMCID: PMC4556460, PII: PONE-D-15-02805, DOI: 10.1371/journal.pone.0136379, ISSN: 1932-6203.

Bowton EA, Collier SP, Wang X, Sutcliffe CB, Van Driest SL, Couch LJ, Herrera M, Jerome RN, Slebos RJ, Alborn WE, Liebler DC, McNaughton CD, Mernaugh RL, Wells QS, Brown NJ, Roden DM, Pulley JM. Phenotype-Driven Plasma Biobanking Strategies and Methods. J Pers Med. 2015; 5(2): 140-52. PMID: 26110578, PMCID: PMC4493492, PII: jpm5020140, DOI: 10.3390/jpm5020140, ISSN: 2075-4426.

Sidorova TN, Mace LC, Wells KS, Yermalitskaya LV, Su PF, Shyr Y, Atkinson JB, Fogo AB, Prinsen JK, Byrne JG, Petracek MR, Greelish JP, Hoff SJ, Ball SK, Glabe CG, Brown NJ, Barnett JV, Murray KT. Hypertension is associated with preamyloid oligomers in human atrium: a missing link in atrial pathophysiology?. J Am Heart Assoc. 2014 Dec; 3(6): e001384. PMID: 25468655, PMCID: PMC4338732, PII: jah3772, DOI: 10.1161/JAHA.114.001384, ISSN: 2047-9980.

Ramirez CE, Shuey MM, Milne GL, Gilbert K, Hui N, Yu C, Luther JM, Brown NJ. Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans. Prostaglandins Other Lipid Mediat [print-electronic]. 2014 Oct; 113-115: 38-44. PMID: 25173047, PMCID: PMC4253976, PII: S1098-8823(14)00032-X, DOI: 10.1016/j.prostaglandins.2014.08.001, ISSN: 1098-8823.

Luther JM, Byrne LM, Yu C, Wang TJ, Brown NJ. Dietary sodium restriction decreases insulin secretion without affecting insulin sensitivity in humans. J. Clin. Endocrinol. Metab [print-electronic]. 2014 Oct; 99(10): E1895-902. PMID: 25029426, PMCID: PMC4184066, DOI: 10.1210/jc.2014-2122, ISSN: 1945-7197.

Devin JK, Pretorius M, Nian H, Yu C, Billings FT, Brown NJ. Dipeptidyl-peptidase 4 inhibition and the vascular effects of glucagon-like peptide-1 and brain natriuretic peptide in the human forearm. J Am Heart Assoc. 2014 Aug; 3(4): PMID: 25158865, PMCID: PMC4310400, PII: jah3617, DOI: 10.1161/JAHA.114.001075, ISSN: 2047-9980.

Laffer CL, Elijovich F, Eckert GJ, Tu W, Pratt JH, Brown NJ. Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans. J Am Soc Hypertens [print-electronic]. 2014 Jul; 8(7): 475-80. PMID: 25064769, PMCID: PMC4115247, PII: S1933-1711(14)00546-4, DOI: 10.1016/j.jash.2014.04.011, ISSN: 1878-7436.

Devin JK, Pretorius M, Nian H, Yu C, Billings FT, Brown NJ. Substance P increases sympathetic activity during combined angiotensin-converting enzyme and dipeptidyl peptidase-4 inhibition. Hypertension [print-electronic]. 2014 May; 63(5): 951-7. PMID: 24516103, PMCID: PMC3984385, PII: HYPERTENSIONAHA.113.02767, DOI: 10.1161/HYPERTENSIONAHA.113.02767, ISSN: 1524-4563.

Sidorova TN, Mace LC, Wells KS, Yermalitskaya LV, Su PF, Shyr Y, Byrne JG, Petracek MR, Greelish JP, Hoff SJ, Ball SK, Glabe CG, Brown NJ, Barnett JV, Murray KT. Quantitative Imaging of Preamyloid Oligomers, a Novel Structural Abnormality, in Human Atrial Samples. J. Histochem. Cytochem [print-electronic]. 2014 Apr 4/30/2014; 62(7): 479-87. PMID: 24789805, PMCID: PMC4072180, PII: 0022155414535782, DOI: 10.1369/0022155414535782, ISSN: 1551-5044.

Dias E, Hachey B, McNaughton C, Nian H, Yu C, Straka B, Brown NJ, Caprioli RM. An LC-MS assay for the screening of cardiovascular medications in human samples. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci [print-electronic]. 2013 Oct 10/15/2013; 937: 44-53. PMID: 24013190, PMCID: PMC3800555, PII: S1570-0232(13)00431-5, DOI: 10.1016/j.jchromb.2013.08.010, ISSN: 1873-376X.

Straka B, Nian H, Sloan C, Byrd JB, Woodard-Grice A, Yu C, Stone E, Steven G, Hartert T, Teo KK, Pare G, McCarty CA, Brown NJ. Pollen count and presentation of angiotensin-converting enzyme inhibitor-associated angioedema. J Allergy Clin Immunol Pract [print-electronic]. 2013 Sep; 1(5): 468-73.e1. PMID: 24565618, PMCID: PMC4042396, PII: S2213-2198(13)00225-0, DOI: 10.1016/j.jaip.2013.05.003, ISSN: 2213-2201.

Brown NJ. Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis. Nat Rev Nephrol [print-electronic]. 2013 Aug; 9(8): 459-69. PMID: 23774812, PMCID: PMC3922409, PII: nrneph.2013.110, DOI: 10.1038/nrneph.2013.110, ISSN: 1759-507X.

Theobald CN, Stover DG, Choma NN, Hathaway J, Green JK, Peterson NB, Sponsler KC, Vasilevskis EE, Kripalani S, Sergent J, Brown NJ, Denny JC. The effect of reducing maximum shift lengths to 16 hours on internal medicine interns' educational opportunities. Acad Med. 2013 Apr; 88(4): 512-8. PMID: 23425987, PMCID: PMC3638874, DOI: 10.1097/ACM.0b013e318285800f, ISSN: 1938-808X.

Gilbert K, Nian H, Yu C, Luther JM, Brown NJ. Fenofibrate lowers blood pressure in salt-sensitive but not salt-resistant hypertension. J. Hypertens. 2013 Apr; 31(4): 820-9. PMID: 23385647, PMCID: PMC3800119, DOI: 10.1097/HJH.0b013e32835e8227, ISSN: 1473-5598.

Balaguer JM, Yu C, Byrne JG, Ball SK, Petracek MR, Brown NJ, Pretorius M. Contribution of endogenous bradykinin to fibrinolysis, inflammation, and blood product transfusion following cardiac surgery: a randomized clinical trial. Clin. Pharmacol. Ther [print-electronic]. 2013 Apr; 93(4): 326-34. PMID: 23361105, PMCID: PMC4031681, PII: clpt2012249, DOI: 10.1038/clpt.2012.249, ISSN: 1532-6535.

Brown NJ. Developing physician-scientists: a perspective. Trans. Am. Clin. Climatol. Assoc. 2013; 124: 218-29. PMID: 23874028, PMCID: PMC3715951, ISSN: 0065-7778.

Pretorius M, Murray KT, Yu C, Byrne JG, Billings FT, Petracek MR, Greelish JP, Hoff SJ, Ball SK, Mishra V, Body SC, Brown NJ. Angiotensin-converting enzyme inhibition or mineralocorticoid receptor blockade do not affect prevalence of atrial fibrillation in patients undergoing cardiac surgery. Crit. Care Med. 2012 Oct; 40(10): 2805-12. PMID: 22824930, PMCID: PMC3588582, DOI: 10.1097/CCM.0b013e31825b8be2, ISSN: 1530-0293.

Luther JM, Luo P, Wang Z, Cohen SE, Kim HS, Fogo AB, Brown NJ. Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury. Kidney Int [print-electronic]. 2012 Sep; 82(6): 643-51. PMID: 22622494, PMCID: PMC3434275, PII: ki2012170, DOI: 10.1038/ki.2012.170, ISSN: 1523-1755.

Billings FT, Pretorius M, Schildcrout JS, Mercaldo ND, Byrne JG, Ikizler TA, Brown NJ. Obesity and oxidative stress predict AKI after cardiac surgery. J. Am. Soc. Nephrol [print-electronic]. 2012 Jul; 23(7): 1221-8. PMID: 22626819, PMCID: PMC3380645, PII: ASN.2011090940, DOI: 10.1681/ASN.2011090940, ISSN: 1533-3450.

Billings FT, Balaguer JM, C Y, Wright P, Petracek MR, Byrne JG, Brown NJ, Pretorius M. Comparative effects of angiotensin receptor blockade and ACE inhibition on the fibrinolytic and inflammatory responses to cardiopulmonary bypass. Clin. Pharmacol. Ther. 2012 Jun; 91(6): 1065-73. PMID: 22549281, PMCID: PMC3822756, PII: clpt2011356, DOI: 10.1038/clpt.2011.356, ISSN: 1532-6535.

Brown NJ. Cardiovascular effects of antidiabetic agents: focus on blood pressure effects of incretin-based therapies. J Am Soc Hypertens [print-electronic]. 2012 May; 6(3): 163-8. PMID: 22433315, PMCID: PMC3422131, PII: S1933-1711(12)00062-9, DOI: 10.1016/j.jash.2012.02.003, ISSN: 1878-7436.

Brown NJ. Patient-oriented research in the era of personalized medicine. Clin Transl Sci [print-electronic]. 2012 Apr; 5(2): 119-20. PMID: 22507115, DOI: 10.1111/j.1752-8062.2011.00394.x, ISSN: 1752-8062.

Ayers K, Byrne LM, DeMatteo A, Brown NJ. Differential effects of nebivolol and metoprolol on insulin sensitivity and plasminogen activator inhibitor in the metabolic syndrome. Hypertension [print-electronic]. 2012 Apr; 59(4): 893-8. PMID: 22353614, PMCID: PMC3402551, PII: HYPERTENSIONAHA.111.189589, DOI: 10.1161/HYPERTENSIONAHA.111.189589, ISSN: 1524-4563.

Gamboa JL, Pretorius M, Todd-Tzanetos DR, Luther JM, Yu C, Ikizler TA, Brown NJ. Comparative effects of angiotensin-converting enzyme inhibition and angiotensin-receptor blockade on inflammation during hemodialysis. J. Am. Soc. Nephrol [print-electronic]. 2012 Feb; 23(2): 334-42. PMID: 22158433, PMCID: PMC3269170, PII: ASN.2011030287, DOI: 10.1681/ASN.2011030287, ISSN: 1533-3450.

Delaney JT, Jeff JM, Brown NJ, Pretorius M, Okafor HE, Darbar D, Roden DM, Crawford DC. Characterization of genome-wide association-identified variants for atrial fibrillation in African Americans. PLoS ONE [print-electronic]. 2012; 7(2): e32338. PMID: 22384221, PMCID: PMC3285683, PII: PONE-D-11-18969, DOI: 10.1371/journal.pone.0032338, ISSN: 1932-6203.

Luther JM, Brown NJ. The renin-angiotensin-aldosterone system and glucose homeostasis. Trends Pharmacol. Sci [print-electronic]. 2011 Dec; 32(12): 734-9. PMID: 21880378, PMCID: PMC3223326, PII: S0165-6147(11)00138-6, DOI: 10.1016/j.tips.2011.07.006, ISSN: 1873-3735.

Darbar M, Emans SJ, Harris ZL, Brown NJ, Scott TA, Cooper WO. Part-time physician faculty in a pediatrics department: a study of equity in compensation and academic advancement. Acad Med. 2011 Aug; 86(8): 968-73. PMID: 21694562, DOI: 10.1097/ACM.0b013e318222317e, ISSN: 1938-808X.

Luther JM, Luo P, Kreger MT, Brissova M, Dai C, Whitfield TT, Kim HS, Wasserman DH, Powers AC, Brown NJ. Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets. Diabetologia [print-electronic]. 2011 Aug; 54(8): 2152-63. PMID: 21519965, PMCID: PMC3216479, DOI: 10.1007/s00125-011-2158-9, ISSN: 1432-0428.

Garg R, Williams GH, Hurwitz S, Brown NJ, Hopkins PN, Adler GK. Low-salt diet increases insulin resistance in healthy subjects. Metab. Clin. Exp [print-electronic]. 2011 Jul; 60(7): 965-8. PMID: 21036373, PMCID: PMC3036792, PII: S0026-0495(10)00329-X, DOI: 10.1016/j.metabol.2010.09.005, ISSN: 1532-8600.

Lee CR, Pretorius M, Schuck RN, Burch LH, Bartlett J, Williams SM, Zeldin DC, Brown NJ. Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with forearm vasodilator responses in humans. Hypertension [print-electronic]. 2011 Jan; 57(1): 116-22. PMID: 21098312, PMCID: PMC3020911, PII: HYPERTENSIONAHA.110.161695, DOI: 10.1161/HYPERTENSIONAHA.110.161695, ISSN: 1524-4563.

Brown NJ. This is not Dr. Conn's aldosterone anymore. Trans. Am. Clin. Climatol. Assoc. 2011; 122: 229-43. PMID: 21686229, PMCID: PMC3116341, ISSN: 0065-7778.

Billings FT, Pretorius M, Siew ED, Yu C, Brown NJ. Early postoperative statin therapy is associated with a lower incidence of acute kidney injury after cardiac surgery. J. Cardiothorac. Vasc. Anesth. 2010 Dec; 24(6): 913-20. PMID: 20599398, PMCID: PMC2992577, PII: S1053-0770(10)00121-7, DOI: 10.1053/j.jvca.2010.03.024, ISSN: 1532-8422.

Byrd JB, Woodard-Grice A, Stone E, Lucisano A, Schaefer H, Yu C, Eyler AE, Salloum NE, Brown NJ. Association of angiotensin-converting enzyme inhibitor-associated angioedema with transplant and immunosuppressant use. Allergy. 2010 Nov; 65(11): 1381-7. PMID: 20557296, PMCID: PMC3305268, PII: ALL2398, DOI: 10.1111/j.1398-9995.2010.02398.x, ISSN: 1398-9995.

Brown NJ. Therapeutic potential of plasminogen activator inhibitor-1 inhibitors. Ther Adv Cardiovasc Dis [print-electronic]. 2010 Oct; 4(5): 315-24. PMID: 20660535, PII: 1753944710379126, DOI: 10.1177/1753944710379126, ISSN: 1753-9455.

Woodard-Grice AV, Lucisano AC, Byrd JB, Stone ER, Simmons WH, Brown NJ. Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenet. Genomics. 2010 Sep; 20(9): 532-6. PMID: 20625347, PMCID: PMC2945219, DOI: 10.1097/FPC.0b013e32833d3acb, ISSN: 1744-6880.

Underwood PC, Sun B, Williams JS, Pojoga LH, Chamarthi B, Lasky-Su J, Raby BA, Hopkins PN, Jeunemaitre X, Brown NJ, Adler GK, Williams GH. The relationship between peroxisome proliferator-activated receptor-gamma and renin: a human genetics study. J. Clin. Endocrinol. Metab [print-electronic]. 2010 Sep; 95(9): E75-9. PMID: 20631015, PMCID: PMC2936061, PII: jc.2010-0270, DOI: 10.1210/jc.2010-0270, ISSN: 1945-7197.

Fong P, Stafforini DM, Brown NJ, Pretorius M. Increased blood flow induces oxidative stress through an endothelium- and nitric oxide-independent mechanism. Free Radic. Biol. Med [print-electronic]. 2010 Jul 7/15/2010; 49(2): 301-5. PMID: 20423727, PMCID: PMC2916026, PII: S0891-5849(10)00254-6, DOI: 10.1016/j.freeradbiomed.2010.04.023, ISSN: 1873-4596.

Gilbert KC, Brown NJ. Aldosterone and inflammation. Curr Opin Endocrinol Diabetes Obes. 2010 Jun; 17(3): 199-204. PMID: 20422780, PMCID: PMC4079531, ISSN: 1752-2978.

Saxena AR, Karumanchi SA, Brown NJ, Royle CM, McElrath TF, Seely EW. Increased sensitivity to angiotensin II is present postpartum in women with a history of hypertensive pregnancy. Hypertension [print-electronic]. 2010 May; 55(5): 1239-45. PMID: 20308605, PMCID: PMC2880505, PII: HYPERTENSIONAHA.109.147595, DOI: 10.1161/HYPERTENSIONAHA.109.147595, ISSN: 1524-4563.

Pretorius M, Brown NJ. Endogenous nitric oxide contributes to bradykinin-stimulated glucose uptake but attenuates vascular tissue-type plasminogen activator release. J. Pharmacol. Exp. Ther [print-electronic]. 2010 Jan; 332(1): 291-7. PMID: 19841473, PMCID: PMC2802470, PII: jpet.109.160168, DOI: 10.1124/jpet.109.160168, ISSN: 1521-0103.

Marney AM, Ma J, Luther JM, Ikizler TA, Brown NJ. Endogenous bradykinin contributes to increased plasminogen activator inhibitor 1 antigen following hemodialysis. J. Am. Soc. Nephrol [print-electronic]. 2009 Oct; 20(10): 2246-52. PMID: 19628666, PMCID: PMC2754101, PII: ASN.2009050505, DOI: 10.1681/ASN.2009050505, ISSN: 1533-3450.

Body SC, Collard CD, Shernan SK, Fox AA, Liu KY, Ritchie MD, Perry TE, Muehlschlegel JD, Aranki S, Donahue BS, Pretorius M, Estrada JC, Ellinor PT, Newton-Cheh C, Seidman CE, Seidman JG, Herman DS, Lichtner P, Meitinger T, Pfeufer A, Kääb S, Brown NJ, Roden DM, Darbar D. Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery. Circ Cardiovasc Genet [print-electronic]. 2009 Oct; 2(5): 499-506. PMID: 20031626, PMCID: PMC2801871, PII: CIRCGENETICS.109.849075, DOI: 10.1161/CIRCGENETICS.109.849075, ISSN: 1942-3268.

Brown NJ, Byiers S, Carr D, Maldonado M, Warner BA. Dipeptidyl peptidase-IV inhibitor use associated with increased risk of ACE inhibitor-associated angioedema. Hypertension [print-electronic]. 2009 Sep; 54(3): 516-23. PMID: 19581505, PMCID: PMC2758288, PII: HYPERTENSIONAHA.109.134197, DOI: 10.1161/HYPERTENSIONAHA.109.134197, ISSN: 1524-4563.

Luther JM, Wang Z, Ma J, Makhanova N, Kim HS, Brown NJ. Endogenous aldosterone contributes to acute angiotensin II-stimulated plasminogen activator inhibitor-1 and preproendothelin-1 expression in heart but not aorta. Endocrinology [print-electronic]. 2009 May; 150(5): 2229-36. PMID: 19106220, PMCID: PMC2671907, PII: en.2008-1296, DOI: 10.1210/en.2008-1296, ISSN: 1945-7170.

Lea WB, Kwak ES, Luther JM, Fowler SM, Wang Z, Ma J, Fogo AB, Brown NJ. Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt. Kidney Int [print-electronic]. 2009 May; 75(9): 936-44. PMID: 19225557, PMCID: PMC2770712, PII: ki20099, DOI: 10.1038/ki.2009.9, ISSN: 1523-1755.

Hill KD, Eckhauser AW, Marney A, Brown NJ. Phosphodiesterase 5 inhibition improves beta-cell function in metabolic syndrome. Diabetes Care [print-electronic]. 2009 May; 32(5): 857-9. PMID: 19196886, PMCID: PMC2671107, PII: dc08-1862, DOI: 10.2337/dc08-1862, ISSN: 1935-5548.

Schoenhard JA, Asselbergs FW, Poku KA, Stocki SA, Gordon S, Vaughan DE, Brown NJ, Moore JH, Williams SM. Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population. Hum. Genet [print-electronic]. 2008 Dec; 124(5): 479-88. PMID: 18953568, PMCID: PMC2770717, DOI: 10.1007/s00439-008-0573-x, ISSN: 1432-1203.

Fleming GA, Murray KT, Yu C, Byrne JG, Greelish JP, Petracek MR, Hoff SJ, Ball SK, Brown NJ, Pretorius M. Milrinone use is associated with postoperative atrial fibrillation after cardiac surgery. Circulation [print-electronic]. 2008 Oct 10/14/2008; 118(16): 1619-25. PMID: 18824641, PMCID: PMC2770257, PII: CIRCULATIONAHA.108.790162, DOI: 10.1161/CIRCULATIONAHA.108.790162, ISSN: 1524-4539.

Brown AM, Morrow JD, Limbird LE, Byrne DW, Gabbe SG, Balser JR, Brown NJ. Centralized oversight of physician-scientist faculty development at Vanderbilt: early outcomes. Acad Med. 2008 Oct; 83(10): 969-75. PMID: 18820531, PMCID: PMC3780596, PII: 00001888-200810000-00018, DOI: 10.1097/ACM.0b013e3181850950, ISSN: 1938-808X.

Gainer JV, Lipkowitz MS, Yu C, Waterman MR, Dawson EP, Capdevila JH, Brown NJ, . Association of a CYP4A11 variant and blood pressure in black men. J. Am. Soc. Nephrol [print-electronic]. 2008 Aug; 19(8): 1606-12. PMID: 18385420, PMCID: PMC2488260, PII: ASN.2008010063, DOI: 10.1681/ASN.2008010063, ISSN: 1533-3450.

Pretorius M, van Guilder GP, Guzman RJ, Luther JM, Brown NJ. 17Beta-estradiol increases basal but not bradykinin-stimulated release of active t-PA in young postmenopausal women. Hypertension [print-electronic]. 2008 Apr; 51(4): 1190-6. PMID: 18259028, PMCID: PMC2673569, PII: HYPERTENSIONAHA.107.105627, DOI: 10.1161/HYPERTENSIONAHA.107.105627, ISSN: 1524-4563.

Van Guilder GP, Pretorius M, Luther JM, Byrd JB, Hill K, Gainer JV, Brown NJ. Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition. Hypertension [print-electronic]. 2008 Feb; 51(2): 454-9. PMID: 18180402, PMCID: PMC2581632, PII: HYPERTENSIONAHA.107.102574, DOI: 10.1161/HYPERTENSIONAHA.107.102574, ISSN: 1524-4563.

Brown NJ. Aldosterone and vascular inflammation. Hypertension [print-electronic]. 2008 Feb; 51(2): 161-7. PMID: 18172061, PII: HYPERTENSIONAHA.107.095489, DOI: 10.1161/HYPERTENSIONAHA.107.095489, ISSN: 1524-4563.

Byrd JB, Touzin K, Sile S, Gainer JV, Yu C, Nadeau J, Adam A, Brown NJ. Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema. Hypertension [print-electronic]. 2008 Jan; 51(1): 141-7. PMID: 18025295, PMCID: PMC2749928, PII: HYPERTENSIONAHA.107.096552, DOI: 10.1161/HYPERTENSIONAHA.107.096552, ISSN: 1524-4563.

Pretorius MM, Gainer JV, Van Guilder GP, Coelho EB, Luther JM, Fong P, Rosenbaum DD, Malave HA, Yu C, Ritchie MD, Vaughan DE, Brown NJ. The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance. Clin. Pharmacol. Ther [print-electronic]. 2008 Jan; 83(1): 122-9. PMID: 17522594, PII: 6100250, DOI: 10.1038/sj.clpt.6100250, ISSN: 1532-6535.

Sile S, Gillani NB, Velez DR, Vanoye CG, Yu C, Byrne LM, Gainer JV, Brown NJ, Williams SM, George AL. Functional BSND variants in essential hypertension. Am. J. Hypertens. 2007 Nov; 20(11): 1176-82. PMID: 17954364, PII: S0895-7061(07)00388-3, DOI: 10.1016/j.amjhyper.2007.07.003, ISSN: 0895-7061.

Pretorius M, Donahue BS, Yu C, Greelish JP, Roden DM, Brown NJ. Plasminogen activator inhibitor-1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass. Circulation. 2007 Sep 9/11/2007; 116(11 Suppl): I1-7. PMID: 17846288, PII: 116/11_suppl/I-1, DOI: 10.1161/CIRCULATIONAHA.106.677906, ISSN: 1524-4539.

Marney AM, Brown NJ. Aldosterone and end-organ damage. Clin. Sci. 2007 Sep; 113(6): 267-78. PMID: 17683282, PII: CS20070123, DOI: 10.1042/CS20070123, ISSN: 1470-8736.

Byrd JB, Shreevatsa A, Putlur P, Foretia D, McAlexander L, Sinha T, Does MD, Brown NJ. Dipeptidyl peptidase IV deficiency increases susceptibility to angiotensin-converting enzyme inhibitor-induced peritracheal edema. J. Allergy Clin. Immunol [print-electronic]. 2007 Aug; 120(2): 403-8. PMID: 17531305, PII: S0091-6749(07)00760-9, DOI: 10.1016/j.jaci.2007.04.012, ISSN: 0091-6749.

Brown NJ, Bradford J, Wang Z, Lea W, Ma L, Ma J, Vaughan DE, Fogo AB. Modulation of angiotensin II and norepinephrine-induced plasminogen activator inhibitor-1 expression by AT1a receptor deficiency. Kidney Int [print-electronic]. 2007 Jul; 72(1): 72-81. PMID: 17429342, PII: 5002268, DOI: 10.1038/sj.ki.5002268, ISSN: 0085-2538.

Chamarthi B, Kolatkar NS, Hunt SC, Williams JS, Seely EW, Brown NJ, Murphey LJ, Jeunemaitre X, Williams GH. Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension. J. Clin. Endocrinol. Metab [print-electronic]. 2007 Apr; 92(4): 1340-6. PMID: 17264181, PII: jc.2006-2093, DOI: 10.1210/jc.2006-2093, ISSN: 0021-972X.

Gumieniak O, Perlstein TS, Williams JS, Hopkins PN, Brown NJ, Raby BA, Williams GH. Ala92 type 2 deiodinase allele increases risk for the development of hypertension. Hypertension [print-electronic]. 2007 Mar; 49(3): 461-6. PMID: 17224473, PII: 01.HYP.0000256295.72185.fd, DOI: 10.1161/01.HYP.0000256295.72185.fd, ISSN: 1524-4563.

LeFebvre J, Shintani A, Gebretsadik T, Petro JR, Murphey LJ, Brown NJ. Bradykinin B(2) receptor does not contribute to blood pressure lowering during AT(1) receptor blockade. J. Pharmacol. Exp. Ther [print-electronic]. 2007 Mar; 320(3): 1261-7. PMID: 17182977, PII: jpet.106.117259, DOI: 10.1124/jpet.106.117259, ISSN: 0022-3565.

Muldowney JA, Painter CA, Sanders-Bush E, Brown NJ, Vaughan DE. Acute tissue-type plasminogen activator release in human microvascular endothelial cells: the roles of Galphaq, PLC-beta, IP3 and 5,6-epoxyeicosatrienoic acid. Thromb. Haemost. 2007 Feb; 97(2): 263-71. PMID: 17264956, PII: 07020263, ISSN: 0340-6245.

Williams SM, Stocki S, Jiang L, Brew K, Gordon S, Vaughan DE, Brown NJ, Poku KA, Moore JH. A population-based study in Ghana to investigate inter-individual variation in plasma t-PA and PAI-1. Ethn Dis. 2007; 17(3): 492-7. PMID: 17985503, ISSN: 1049-510X.

Luther JM, Gainer JV, Murphey LJ, Yu C, Vaughan DE, Morrow JD, Brown NJ. Angiotensin II induces interleukin-6 in humans through a mineralocorticoid receptor-dependent mechanism. Hypertension [print-electronic]. 2006 Dec; 48(6): 1050-7. PMID: 17043157, PII: 01.HYP.0000248135.97380.76, DOI: 10.1161/01.HYP.0000248135.97380.76, ISSN: 1524-4563.

Byrd JB, Adam A, Brown NJ. Angiotensin-converting enzyme inhibitor-associated angioedema. Immunol Allergy Clin North Am. 2006 Nov; 26(4): 725-37. PMID: 17085287, PII: S0889-8561(06)00074-9, DOI: 10.1016/j.iac.2006.08.001, ISSN: 0889-8561.

Pojoga L, Kolatkar NS, Williams JS, Perlstein TS, Jeunemaitre X, Brown NJ, Hopkins PN, Raby BA, Williams GH. Beta-2 adrenergic receptor diplotype defines a subset of salt-sensitive hypertension. Hypertension [print-electronic]. 2006 Nov; 48(5): 892-900. PMID: 17015767, PII: 01.HYP.0000244688.45472.95, DOI: 10.1161/01.HYP.0000244688.45472.95, ISSN: 1524-4563.

Murphey LJ, Malave HA, Petro J, Biaggioni I, Byrne DW, Vaughan DE, Luther JM, Pretorius M, Brown NJ. Bradykinin and its metabolite bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humans. J. Pharmacol. Exp. Ther [print-electronic]. 2006 Sep; 318(3): 1287-92. PMID: 16772538, PII: jpet.106.104026, DOI: 10.1124/jpet.106.104026, ISSN: 0022-3565.

Brown NJ. Blood pressure reduction and tissue-type plasminogen activator release [editorial]. Hypertension [print-electronic]. 2006 Apr; 47(4): 648-9. PMID: 16520404, PII: 01.HYP.0000209952.30603.e9, DOI: 10.1161/01.HYP.0000209952.30603.e9, ISSN: 1524-4563.

Brown NJ, Muldowney JA, Vaughan DE. Endogenous NO regulates plasminogen activator inhibitor-1 during angiotensin-converting enzyme inhibition. Hypertension [print-electronic]. 2006 Mar; 47(3): 441-8. PMID: 16432054, PII: 01.HYP.0000202478.79587.1a, DOI: 10.1161/01.HYP.0000202478.79587.1a, ISSN: 1524-4563.

Ma J, Weisberg A, Griffin JP, Vaughan DE, Fogo AB, Brown NJ. Plasminogen activator inhibitor-1 deficiency protects against aldosterone-induced glomerular injury. Kidney Int. 2006 Mar; 69(6): 1064-72. PMID: 16528256, PII: 5000201, DOI: 10.1038/sj.ki.5000201, ISSN: 0085-2538.

Williams JS, Williams GH, Raji A, Jeunemaitre X, Brown NJ, Hopkins PN, Conlin PR. Prevalence of primary hyperaldosteronism in mild to moderate hypertension without hypokalaemia. J Hum Hypertens. 2006 Feb; 20(2): 129-36. PMID: 16292348, PII: 1001948, DOI: 10.1038/sj.jhh.1001948, ISSN: 0950-9240.

Motsinger AA, Donahue BS, Brown NJ, Roden DM, Ritchie MD. Risk factor interactions and genetic effects associated with post-operative atrial fibrillation. Pac Symp Biocomput. 2006; 584-95. PMID: 17094271, ISSN: 2335-6936.

Pretorius M, Scholl FG, McFarlane JA, Murphey LJ, Brown NJ. A pilot study indicating that bradykinin B2 receptor antagonism attenuates protamine-related hypotension after cardiopulmonary bypass. Clin. Pharmacol. Ther. 2005 Nov; 78(5): 477-85. PMID: 16321614, PII: S0009-9236(05)00359-0, DOI: 10.1016/j.clpt.2005.08.010, ISSN: 0009-9236.

Aldigier JC, Kanjanbuch T, Ma LJ, Brown NJ, Fogo AB. Regression of existing glomerulosclerosis by inhibition of aldosterone. J. Am. Soc. Nephrol [print-electronic]. 2005 Nov; 16(11): 3306-14. PMID: 16192423, PII: ASN.2004090804, DOI: 10.1681/ASN.2004090804, ISSN: 1046-6673.

Pretorius M, Luther JM, Murphey LJ, Vaughan DE, Brown NJ. Angiotensin-converting enzyme inhibition increases basal vascular tissue plasminogen activator release in women but not in men. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2005 Nov; 25(11): 2435-40. PMID: 16166566, PII: 01.ATV.0000186185.13977.94, DOI: 10.1161/01.ATV.0000186185.13977.94, ISSN: 1524-4636.

Xu BJ, Shyr Y, Liang X, Ma LJ, Donnert EM, Roberts JD, Zhang X, Kon V, Brown NJ, Caprioli RM, Fogo AB. Proteomic patterns and prediction of glomerulosclerosis and its mechanisms. J. Am. Soc. Nephrol [print-electronic]. 2005 Oct; 16(10): 2967-75. PMID: 16079267, PII: ASN.2005030262, DOI: 10.1681/ASN.2005030262, ISSN: 1046-6673.

Ma J, Albornoz F, Yu C, Byrne DW, Vaughan DE, Brown NJ. Differing effects of mineralocorticoid receptor-dependent and -independent potassium-sparing diuretics on fibrinolytic balance. Hypertension [print-electronic]. 2005 Aug; 46(2): 313-20. PMID: 15998706, PII: 01.HYP.0000174327.53863.86, DOI: 10.1161/01.HYP.0000174327.53863.86, ISSN: 1524-4563.

Brown NJ. Aldosterone and end-organ damage. Curr. Opin. Nephrol. Hypertens. 2005 May; 14(3): 235-41. PMID: 15821416, PII: 00041552-200505000-00008, ISSN: 1062-4821.

Weisberg AD, Albornoz F, Griffin JP, Crandall DL, Elokdah H, Fogo AB, Vaughan DE, Brown NJ. Pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 attenuates angiotensin II/salt-induced aortic remodeling. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2005 Feb; 25(2): 365-71. PMID: 15576638, PII: 01.ATV.0000152356.85791.52, DOI: 10.1161/01.ATV.0000152356.85791.52, ISSN: 1524-4636.

Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation [print-electronic]. 2005 Jan 1/4/2005; 111(1): 63-9. PMID: 15611369, PII: 01.CIR.0000151309.82473.59, DOI: 10.1161/01.CIR.0000151309.82473.59, ISSN: 1524-4539.

Muldowney JA, Davis SN, Vaughan DE, Brown NJ. NO synthase inhibition increases aldosterone in humans. Hypertension [print-electronic]. 2004 Nov; 44(5): 739-45. PMID: 15381675, PII: 01.HYP.0000143852.48258.f1, DOI: 10.1161/01.HYP.0000143852.48258.f1, ISSN: 1524-4563.

Nieman MT, Warnock M, Hasan AA, Mahdi F, Lucchesi BR, Brown NJ, Murphey LJ, Schmaier AH. The preparation and characterization of novel peptide antagonists to thrombin and factor VIIa and activation of protease-activated receptor 1. J. Pharmacol. Exp. Ther [print-electronic]. 2004 Nov; 311(2): 492-501. PMID: 15210836, PII: jpet.104.069229, DOI: 10.1124/jpet.104.069229, ISSN: 0022-3565.

Pretorius M, McFarlane JA, Vaughan DE, Brown NJ, Murphey LJ. Angiotensin-converting enzyme inhibition and smoking potentiate the kinin response to cardiopulmonary bypass. Clin. Pharmacol. Ther. 2004 Oct; 76(4): 379-87. PMID: 15470338, PII: S0009923604002000, DOI: 10.1016/j.clpt.2004.06.004, ISSN: 0009-9236.

Perlstein TS, Gumieniak O, Hopkins PN, Murphey LJ, Brown NJ, Williams GH, Hollenberg NK, Fisher ND. Uric acid and the state of the intrarenal renin-angiotensin system in humans. Kidney Int. 2004 Oct; 66(4): 1465-70. PMID: 15458439, PII: KID909, DOI: 10.1111/j.1523-1755.2004.00909.x, ISSN: 0085-2538.

Gumieniak O, Perlstein TS, Hopkins PN, Brown NJ, Murphey LJ, Jeunemaitre X, Hollenberg NK, Williams GH. Thyroid function and blood pressure homeostasis in euthyroid subjects. J. Clin. Endocrinol. Metab. 2004 Jul; 89(7): 3455-61. PMID: 15240631, PII: 89/7/3455, DOI: 10.1210/jc.2003-032143, ISSN: 0021-972X.

Ridker PM, Brown NJ, Vaughan DE, Harrison DG, Mehta JL. Established and emerging plasma biomarkers in the prediction of first atherothrombotic events. Circulation. 2004 Jun 6/29/2004; 109(25 Suppl 1): IV6-19. PMID: 15226246, PII: 109/25_suppl_1/IV-6, DOI: 10.1161/01.CIR.0000133444.17867.56, ISSN: 1524-4539.

Murphey LJ, Eccles WK, Williams GH, Brown NJ. Loss of sodium modulation of plasma kinins in human hypertension. J. Pharmacol. Exp. Ther [print-electronic]. 2004 Mar; 308(3): 1046-52. PMID: 14718610, PII: jpet.103.059337, DOI: 10.1124/jpet.103.059337, ISSN: 0022-3565.

Ma LJ, Mao SL, Taylor KL, Kanjanabuch T, Guan Y, Zhang Y, Brown NJ, Swift LL, McGuinness OP, Wasserman DH, Vaughan DE, Fogo AB. Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes. 2004 Feb; 53(2): 336-46. PMID: 14747283, ISSN: 0012-1797.

Summar ML, Gainer JV, Pretorius M, Malave H, Harris S, Hall LD, Weisberg A, Vaughan DE, Christman BW, Brown NJ. Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function. Hypertension [print-electronic]. 2004 Feb; 43(2): 186-91. PMID: 14718356, PII: 01.HYP.0000112424.06921.52, DOI: 10.1161/01.HYP.0000112424.06921.52, ISSN: 1524-4563.

Pretorius M, Murphey LJ, McFarlane JA, Vaughan DE, Brown NJ. Angiotensin-converting enzyme inhibition alters the fibrinolytic response to cardiopulmonary bypass. Circulation [print-electronic]. 2003 Dec 12/23/2003; 108(25): 3079-83. PMID: 14656921, PII: 01.CIR.0000105765.54573.60, DOI: 10.1161/01.CIR.0000105765.54573.60, ISSN: 1524-4539.

Eren M, Painter CA, Gleaves LA, Schoenhard JA, Atkinson JB, Brown NJ, Vaughan DE. Tissue- and agonist-specific regulation of human and murine plasminogen activator inhibitor-1 promoters in transgenic mice. J. Thromb. Haemost. 2003 Nov; 1(11): 2389-96. PMID: 14629474, PII: 437, ISSN: 1538-7933.

Murphey LJ, Morrow JD, Sawathiparnich P, Williams GH, Vaughan DE, Brown NJ. Acute angiotensin II increases plasma F2-isoprostanes in salt-replete human hypertensives. Free Radic. Biol. Med. 2003 Oct 10/1/2003; 35(7): 711-8. PMID: 14583335, PII: S0891584903003952, ISSN: 0891-5849.

Sawathiparnich P, Murphey LJ, Kumar S, Vaughan DE, Brown NJ. Effect of combined AT1 receptor and aldosterone receptor antagonism on plasminogen activator inhibitor-1. J. Clin. Endocrinol. Metab. 2003 Aug; 88(8): 3867-73. PMID: 12915681, DOI: 10.1210/jc.2003-030374, ISSN: 0021-972X.

Brown NJ. Eplerenone: cardiovascular protection. Circulation. 2003 May 5/20/2003; 107(19): 2512-8. PMID: 12756192, PII: 107/19/2512, DOI: 10.1161/01.CIR.0000071081.35693.9A, ISSN: 1524-4539.

Pretorius M, Rosenbaum D, Vaughan DE, Brown NJ. Angiotensin-converting enzyme inhibition increases human vascular tissue-type plasminogen activator release through endogenous bradykinin. Circulation. 2003 Feb 2/4/2003; 107(4): 579-85. PMID: 12566370, ISSN: 1524-4539.

Bellamine A, Wang Y, Waterman MR, Gainer JV, Dawson EP, Brown NJ, Capdevila JH. Characterization of the CYP4A11 gene, a second CYP4A gene in humans. Arch. Biochem. Biophys. 2003 Jan 1/1/2003; 409(1): 221-7. PMID: 12464262, PII: S0003986102005453, ISSN: 0003-9861.

Brown NJ, Kumar S, Painter CA, Vaughan DE. ACE inhibition versus angiotensin type 1 receptor antagonism: differential effects on PAI-1 over time. Hypertension. 2002 Dec; 40(6): 859-65. PMID: 12468570, ISSN: 1524-4563.

Meredith S, Feldman P, Frey D, Giammarco L, Hall K, Arnold K, Brown NJ, Ray WA. Improving medication use in newly admitted home healthcare patients: a randomized controlled trial. J Am Geriatr Soc. 2002 Sep; 50(9): 1484-91. PMID: 12383144, PII: jgs50402, ISSN: 0002-8614.

Brown NJ, Vaughan DE, Fogo AB. The renin-angiotensin-aldosterone system and fibrinolysis in progressive renal disease. Semin. Nephrol. 2002 Sep; 22(5): 399-406. PMID: 12224047, PII: S027092950250053X, ISSN: 0270-9295.

Srikumar N, Brown NJ, Hopkins PN, Jeunemaitre X, Hunt SC, Vaughan DE, Williams GH. PAI-1 in human hypertension: relation to hypertensive groups. Am. J. Hypertens. 2002 Aug; 15(8): 683-90. PMID: 12160190, PII: S0895706102029527, ISSN: 0895-7061.

Moore JH, Lamb JM, Brown NJ, Vaughan DE. A comparison of combinatorial partitioning and linear regression for the detection of epistatic effects of the ACE I/D and PAI-1 4G/5G polymorphisms on plasma PAI-1 levels. Clin. Genet. 2002 Jul; 62(1): 74-9. PMID: 12123491, PII: cge620110, ISSN: 0009-9163.

Moore JH, Smolkin ME, Lamb JM, Brown NJ, Vaughan DE. The relationship between plasma t-PA and PAI-1 levels is dependent on epistatic effects of the ACE I/D and PAI-1 4G/5G polymorphisms. Clin. Genet. 2002 Jul; 62(1): 53-9. PMID: 12123488, PII: cge620107, ISSN: 0009-9163.

Rosenbaum DA, Pretorius M, Gainer JV, Byrne D, Murphey LJ, Painter CA, Vaughan DE, Brown NJ. Ethnicity affects vasodilation, but not endothelial tissue plasminogen activator release, in response to bradykinin. Arterioscler. Thromb. Vasc. Biol. 2002 Jun 6/1/2002; 22(6): 1023-8. PMID: 12067915, ISSN: 1524-4636.

Kaikita K, Schoenhard JA, Painter CA, Ripley RT, Brown NJ, Fogo AB, Vaughan DE. Potential roles of plasminogen activator system in coronary vascular remodeling induced by long-term nitric oxide synthase inhibition. J. Mol. Cell. Cardiol. 2002 Jun; 34(6): 617-27. PMID: 12054849, PII: S0022282802920018, DOI: 10.1006/jmcc.2002.2001, ISSN: 0022-2828.

Brown NJ, Vaughan DE, Fogo AB. Aldosterone and PAI-1: implications for renal injury. J. Nephrol. 2002 May; 15(3): 230-5. PMID: 12113592, ISSN: 1121-8428.

Pretorius M, Rosenbaum DA, Lefebvre J, Vaughan DE, Brown NJ. Smoking impairs bradykinin-stimulated t-PA release. Hypertension. 2002 Mar 3/1/2002; 39(3): 767-71. PMID: 11897760, ISSN: 1524-4563.

Lefebvre J, Murphey LJ, Hartert TV, Jiao Shan R, Simmons WH, Brown NJ. Dipeptidyl peptidase IV activity in patients with ACE-inhibitor-associated angioedema. Hypertension. 2002 Feb; 39(2 Pt 2): 460-4. PMID: 11882590, ISSN: 1524-4563.

Sawathiparnich P, Kumar S, Vaughan DE, Brown NJ. Spironolactone abolishes the relationship between aldosterone and plasminogen activator inhibitor-1 in humans. J. Clin. Endocrinol. Metab. 2002 Feb; 87(2): 448-52. PMID: 11836266, DOI: 10.1210/jcem.87.2.7980, ISSN: 0021-972X.

Chylack LT, Brown NP, Bron A, Hurst M, Köpcke W, Thien U, Schalch W. The Roche European American Cataract Trial (REACT): a randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract. Ophthalmic Epidemiol. 2002 Feb; 9(1): 49-80. PMID: 11815895, ISSN: 0928-6586.

Kaikita K, Fogo AB, Ma L, Schoenhard JA, Brown NJ, Vaughan DE. Plasminogen activator inhibitor-1 deficiency prevents hypertension and vascular fibrosis in response to long-term nitric oxide synthase inhibition. Circulation. 2001 Aug 8/14/2001; 104(7): 839-44. PMID: 11502712, ISSN: 1524-4539.

Meredith S, Feldman PH, Frey D, Hall K, Arnold K, Brown NJ, Ray WA. Possible medication errors in home healthcare patients. J Am Geriatr Soc. 2001 Jun; 49(6): 719-24. PMID: 11454109, PII: jgs49147, ISSN: 0002-8614.

Brown NJ, Murphey LJ, Srikuma N, Koschachuhanan N, Williams GH, Vaughan DE. Interactive effect of PAI-1 4G/5G genotype and salt intake on PAI-1 antigen. Arterioscler. Thromb. Vasc. Biol. 2001 Jun; 21(6): 1071-7. PMID: 11397722, ISSN: 1524-4636.

Wilsdorf T, Gainer JV, Murphey LJ, Vaughan DE, Brown NJ. Angiotensin-(1-7) does not affect vasodilator or TPA responses to bradykinin in human forearm. Hypertension. 2001 Apr; 37(4): 1136-40. PMID: 11304515, ISSN: 1524-4563.

Gainer JV, Stein CM, Neal T, Vaughan DE, Brown NJ. Interactive Effect of Ethnicity and ACE Insertion/Deletion Polymorphism on Vascular Reactivity. Hypertension. 2001 Jan; 37(1): 46-51. PMID: 11208755, ISSN: 1524-4563.

Gainer JV, Brown NJ, Bachvarova M, Bastien L, Maltais I, Marceau F, Bachvarov DR. Altered frequency of a promoter polymorphism of the kinin B2 receptor gene in hypertensive African-Americans. Am. J. Hypertens. 2000 Dec; 13(12): 1268-73. PMID: 11130770, PII: S0895706100012152, ISSN: 0895-7061.

Murphey LJ, Kumar S, Brown NJ. Endogenous bradykinin and the renin and pressor responses to furosemide in humans. J. Pharmacol. Exp. Ther. 2000 Nov; 295(2): 644-8. PMID: 11046100, ISSN: 0022-3565.

Brown NJ, Gainer JV, Murphey LJ, Vaughan DE. Bradykinin stimulates tissue plasminogen activator release from human forearm vasculature through B(2) receptor-dependent, NO synthase-independent, and cyclooxygenase-independent pathway. Circulation. 2000 Oct 10/31/2000; 102(18): 2190-6. PMID: 11056091, ISSN: 1524-4539.

Brown NJ, Nakamura S, Ma L, Nakamura I, Donnert E, Freeman M, Vaughan DE, Fogo AB. Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo. Kidney Int. 2000 Sep; 58(3): 1219-27. PMID: 10972684, PII: kid277, DOI: 10.1046/j.1523-1755.2000.00277.x, ISSN: 0085-2538.

Murphey LJ, Gainer JV, Vaughan DE, Brown NJ. Angiotensin-converting enzyme insertion/deletion polymorphism modulates the human in vivo metabolism of bradykinin. Circulation. 2000 Aug 8/22/2000; 102(8): 829-32. PMID: 10952948, ISSN: 1524-4539.

Murphey LJ, Hachey DL, Oates JA, Morrow JD, Brown NJ. Metabolism of bradykinin In vivo in humans: identification of BK1-5 as a stable plasma peptide metabolite. J. Pharmacol. Exp. Ther. 2000 Jul; 294(1): 263-9. PMID: 10871321, ISSN: 0022-3565.

Xie HG, Stein CM, Kim RB, Gainer JV, Sofowora G, Dishy V, Brown NJ, Goree RE, Haines JL, Wood AJ. Human beta2-adrenergic receptor polymorphisms: no association with essential hypertension in black or white Americans. Clin. Pharmacol. Ther. 2000 Jun; 67(6): 670-5. PMID: 10872649, PII: S0009-9236(00)45798-X, DOI: 10.1067/mcp.2000.106293, ISSN: 0009-9236.

Brown NJ, Vaughan DE. Prothrombotic effects of angiotensin. Adv Intern Med. 2000; 45: 419-29. PMID: 10635057, ISSN: 0065-2822.

Brown NJ, Kim KS, Chen YQ, Blevins LS, Nadeau JH, Meranze SG, Vaughan DE. Synergistic effect of adrenal steroids and angiotensin II on plasminogen activator inhibitor-1 production. J. Clin. Endocrinol. Metab. 2000 Jan; 85(1): 336-44. PMID: 10634408, DOI: 10.1210/jcem.85.1.6305, ISSN: 0021-972X.

Kim KS, Kumar S, Simmons WH, Brown NJ. Inhibition of aminopeptidase P potentiates wheal response to bradykinin in angiotensin-converting enzyme inhibitor-treated humans. J. Pharmacol. Exp. Ther. 2000 Jan; 292(1): 295-8. PMID: 10604961, ISSN: 0022-3565.

Xie HG, Kim RB, Stein CM, Gainer JV, Brown NJ, Wood AJ. Alpha1A-adrenergic receptor polymorphism: association with ethnicity but not essential hypertension. Pharmacogenetics. 1999 Oct; 9(5): 651-6. PMID: 10591546, ISSN: 0960-314X.

Xie HG, Stein CM, Kim RB, Xiao ZS, He N, Zhou HH, Gainer JV, Brown NJ, Haines JL, Wood AJ. Frequency of functionally important beta-2 adrenoceptor polymorphisms varies markedly among African-American, Caucasian and Chinese individuals. Pharmacogenetics. 1999 Aug; 9(4): 511-6. PMID: 10780271, ISSN: 0960-314X.

Brown NJ, Agirbasli M, Vaughan DE. Comparative effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor antagonism on plasma fibrinolytic balance in humans. Hypertension. 1999 Aug; 34(2): 285-90. PMID: 10454455, ISSN: 0194-911X.

Brown NJ, Gainer JV, Stein CM, Vaughan DE. Bradykinin stimulates tissue plasminogen activator release in human vasculature. Hypertension. 1999 Jun; 33(6): 1431-5. PMID: 10373228, ISSN: 0194-911X.

Brown NJ, Agirbasli MA, Williams GH, Litchfield WR, Vaughan DE. Effect of activation and inhibition of the renin-angiotensin system on plasma PAI-1. Hypertension. 1998 Dec; 32(6): 965-71. PMID: 9856958, ISSN: 0194-911X.

Brown NJ, Griffin MR, Ray WA, Meredith S, Beers MH, Marren J, Robles M, Stergachis A, Wood AJ, Avorn J. A model for improving medication use in home health care patients. J Am Pharm Assoc (Wash). 1998 Nov; 38(6): 696-702. PMID: 9861787, ISSN: 1086-5802.

Gainer JV, Morrow JD, Loveland A, King DJ, Brown NJ. Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects. N. Engl. J. Med. 1998 Oct 10/29/1998; 339(18): 1285-92. PMID: 9791144, DOI: 10.1056/NEJM199810293391804, ISSN: 0028-4793.

Brown NJ, Blais C, Gandhi SK, Adam A. ACE insertion/deletion genotype affects bradykinin metabolism. J. Cardiovasc. Pharmacol. 1998 Sep; 32(3): 373-7. PMID: 9733349, ISSN: 0160-2446.

Brown NJ, Vaughan DE. Angiotensin-converting enzyme inhibitors. Circulation. 1998 Apr 4/14/1998; 97(14): 1411-20. PMID: 9577953, ISSN: 0009-7322.

Gandhi SK, Gainer J, King D, Brown NJ. Gender affects renal vasoconstrictor response to Ang I and Ang II. Hypertension. 1998 Jan; 31(1): 90-6. PMID: 9449397, ISSN: 0194-911X.

Gainer JV, Hunley TE, Kon V, Nadeau JH, Muldowney JA, Brown NJ. Angiotensin II type I receptor polymorphism in African Americans lower frequency of the C1166 variant. Biochem. Mol. Biol. Int. 1997 Sep; 43(1): 227-31. PMID: 9315301, ISSN: 1039-9712.

Brown NJ, Snowden M, Griffin MR. Recurrent angiotensin-converting enzyme inhibitor--associated angioedema. JAMA. 1997 Jul 7/16/1997; 278(3): 232-3. PMID: 9218671, ISSN: 0098-7484.

Brown NJ, Nadeau JH, Vaughan DE. Selective stimulation of tissue-type plasminogen activator (t-PA) in vivo by infusion of bradykinin. Thromb. Haemost. 1997 Mar; 77(3): 522-5. PMID: 9066005, ISSN: 0340-6245.

Gandhi SK, Ryder DH, Brown NJ. Losartan blocks aldosterone and renal vascular responses to angiotensin II in humans. Hypertension. 1996 Dec; 28(6): 961-6. PMID: 8952583, ISSN: 0194-911X.

Brown NJ, Ryder D, Gainer JV, Morrow JD, Nadeau J. Differential effects of angiotensin converting enzyme inhibitors on the vasodepressor and prostacyclin responses to bradykinin. J. Pharmacol. Exp. Ther. 1996 Nov; 279(2): 703-12. PMID: 8930174, ISSN: 0022-3565.

Gainer JV, Nadeau JH, Ryder D, Brown NJ. Increased sensitivity to bradykinin among African Americans. J. Allergy Clin. Immunol. 1996 Aug; 98(2): 283-7. PMID: 8757204, PII: S0091-6749(96)70151-3, ISSN: 0091-6749.

Brown NJ, Ray WA, Snowden M, Griffin MR. Black Americans have an increased rate of angiotensin converting enzyme inhibitor-associated angioedema. Clin. Pharmacol. Ther. 1996 Jul; 60(1): 8-13. PMID: 8689816, PII: S0009-9236(96)90161-7, DOI: 10.1016/S0009-9236(96)90161-7, ISSN: 0009-9236.

Hunley TE, Julian BA, Phillips JA, Summar ML, Yoshida H, Horn RG, Brown NJ, Fogo A, Ichikawa I, Kon V. Angiotensin converting enzyme gene polymorphism: potential silencer motif and impact on progression in IgA nephropathy. Kidney Int. 1996 Feb; 49(2): 571-7. PMID: 8821846, ISSN: 0085-2538.

Daniel VC, Minton TA, Brown NJ, Nadeau JH, Morrow JD. Simplified assay for the quantification of 2,3-dinor-6-keto-prostaglandin F1 alpha by gas chromatography-mass spectrometry. J. Chromatogr. B, Biomed. Appl. 1994 Mar 3/4/1994; 653(2): 117-22. PMID: 8205238, ISSN: 1572-6495.

Brown NJ, Ryder D, Nadeau J. Caffeine attenuates the renal vascular response to angiotensin II infusion. Hypertension. 1993 Dec; 22(6): 847-52. PMID: 8244516, ISSN: 0194-911X.

Brown NJ, Ryder D, Branch RA. A pharmacodynamic interaction between caffeine and phenylpropanolamine. Clin. Pharmacol. Ther. 1991 Oct; 50(4): 363-71. PMID: 1914371, ISSN: 0009-9236.

Brown NJ, McKenzie S, Decker MD. Case report: fatal pulmonary toxoplasmosis following chemotherapy. Am. J. Med. Sci. 1991 Sep; 302(3): 152-4. PMID: 1928224, ISSN: 0002-9629.

Brown NJ, Porter J, Ryder D, Branch RA. Caffeine potentiates the renin response to diazoxide in man. Evidence for a regulatory role of endogenous adenosine. J. Pharmacol. Exp. Ther. 1991 Jan; 256(1): 56-61. PMID: 1988669, ISSN: 0022-3565.

Brown NJ. Octreotide: a long-acting somatostatin analog. Am. J. Med. Sci. 1990 Oct; 300(4): 267-73. PMID: 2248280, ISSN: 0002-9629.

Available Postdoctoral Position Details
Posted: 11/26/2013
Postdoctoral positions available for clinical and translational investigators