Terence S. Dermody, M.D.

Professor

terry.dermody@vanderbilt.edu

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Faculty Appointments
Director, Pediatric Infectious Diseases Professor of Pediatrics Dorothy Overall Wells Chair in PediatricsProfessor of Pathology, Microbiology and Immunology
Education
M.D., Medicine, Columbia University, New York, New YorkB.S., Biology, Cornell University, Ithaca, New York
Office Address
D-6227 MCN
Lamb Center for Pediatric Research
1161 21st Avenue South
Nashville, TN 2581
Research Description
Our lab studies the molecular pathogenesis of mammalian reovirus and chikungunya virus infections. Reovirus is an enteric, neurotropic virus that infects many mammalian species, including humans, but disease is restricted to the very young. Chikungunya virus is an emerging arthropod-borne alphavirus that causes epidemics of febrile arthritis in humans. Research in my laboratory encompasses several interrelated themes to better understand viral and cellular mediators of disease. These include the structural basis of viral attachment and entry into cells, mechanisms of genome replication and packaging, patterns of cell signaling and gene expression occurring in response to viral infection, mechanisms of virus-induced apoptosis and its significance in the viral life cycle, and roles of viral receptor distribution and utilization in disease pathology. We also are developing viral vectors for oncolytic and vaccine applications.

(1) Reovirus receptors and pathogenesis. Following peroral inoculation of newborn mice, reovirus disseminates systemically to target the heart, liver, and central nervous system. We are conducting experiments to investigate the role of reovirus receptors, sialic acid, junctional adhesion molecule A (JAM-A), and Nogo receptor-1 (NgR1) in reovirus dissemination and tropism. These studies employ primary cells and mice lacking reovirus receptors. This work will be interpreted in the context of ongoing studies to determine the structure of reovirus in complex with its receptors. Since not all of the reovirus receptors are known, we are working to identify additional reovirus receptors.

(2) Reovirus cell entry and replication. Reovirus enters cells by clathrin-dependent endocytosis in an integrin-dependent process and undergoes proteolytic disassembly in endosomes. Studies are in progress to define mechanisms of reovirus uptake and transport within the endocytic pathway. We also are working to define how the viral gene products reorganize cellular architecture to form the viral replication organelles that serve as sites for genome replication and particle assembly. This research will reveal mechanisms by which viral and cellular factors cooperate to facilitate viral replication and illuminate new targets for therapeutic intervention.

(3) Reovirus-induced apoptosis. Reovirus induces apoptosis in cultured cells and in the murine central nervous system and heart. Our studies indicate that apoptosis is triggered by innate immune response signal transducers initiated by viral components following reovirus disassembly. Experiments are in progress to identify components of the cell-signaling apparatus required for apoptosis induction by reovirus and to determine the relationship between apoptosis and virulence. These studies will establish new ideas about how RNA-containing viruses interact with innate immune response signaling circuits and lead to a better understanding of how viruses injure their host cells.

(4) Chikungunya virus (CHIKV) attachment and cell entry. CHIKV has produced explosive outbreaks in East Africa, several islands in the Indian Ocean, India, Southeast Asia, and most recently the Caribbean. We have found that attenuated CHIKV vaccine strain 181/25 engages heparan sulfate proteoglycans to initiate infection. Ongoing work is focused on identification of host cell proteins that contribute to CHIKV replication and definition of CHIKV virulence determinants. This research will fill major gaps in an understanding of CHIKV pathogenesis and illuminate new targets for antiviral therapies and vaccines.
Research Keywords
Viral pathogenesis and vaccine development
Publications
Mainou BA, Ashbrook AW, Smith EC, Dorset DC, Denison MR, Dermody TS. Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry. J. Virol [print-electronic]. 2015 Sep; 89(17): 8701-12. PMID: 26109733, PMCID: PMC4524060, PII: JVI.00739-15, DOI: 10.1128/JVI.00739-15, ISSN: 1098-5514.

Smith SA, Silva LA, Fox JM, Flyak AI, Kose N, Sapparapu G, Khomandiak S, Ashbrook AW, Kahle KM, Fong RH, Swayne S, Doranz BJ, McGee CE, Heise MT, Pal P, Brien JD, Austin SK, Diamond MS, Dermody TS, Crowe JE. Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus. Cell Host Microbe. 2015 Jul 7/8/2015; 18(1): 86-95. PMID: 26159721, PMCID: PMC4501771, PII: S1931-3128(15)00257-7, DOI: 10.1016/j.chom.2015.06.009, ISSN: 1934-6069.

Stettner E, Dietrich MH, Reiss K, Dermody TS, Stehle T. Structure of Serotype 1 Reovirus Attachment Protein s1 in Complex with Junctional Adhesion Molecule A Reveals a Conserved Serotype-Independent Binding Epitope. J. Virol [print-electronic]. 2015 Jun; 89(11): 6136-40. PMID: 25810543, PMCID: PMC4442426, PII: JVI.00433-15, DOI: 10.1128/JVI.00433-15, ISSN: 1098-5514.

Bills JL, VanHouten J, Grundy MM, Chalkley R, Dermody TS. Validity of the Medical College Admission Test for predicting MD-PhD student outcomes. Adv Health Sci Educ Theory Pract [print-electronic]. 2015 May 5/8/2015; PMID: 25952644, DOI: 10.1007/s10459-015-9609-x, ISSN: 1573-1677.

Doyle JD, Stencel-Baerenwald JE, Copeland CA, Rhoads JP, Brown JJ, Boyd KL, Atkinson JB, Dermody TS. Diminished reovirus capsid stability alters disease pathogenesis and littermate transmission. PLoS Pathog. 2015 Mar; 11(3): e1004693. PMID: 25738608, PMCID: PMC4349883, PII: PPATHOGENS-D-14-01125, DOI: 10.1371/journal.ppat.1004693, ISSN: 1553-7374.

Lai CM, Boehme KW, Pruijssers AJ, Parekh VV, Van Kaer L, Parkos CA, Dermody TS. Endothelial JAM-A promotes reovirus viremia and bloodstream dissemination. J. Infect. Dis [print-electronic]. 2015 Feb 2/1/2015; 211(3): 383-93. PMID: 25149763, PMCID: PMC4351375, PII: jiu476, DOI: 10.1093/infdis/jiu476, ISSN: 1537-6613.

Casadevall A, Dermody TS, Imperiale MJ, Sandri-Goldin RM, Shenk T. Dual-Use Research of Concern (DURC) Review at American Society for Microbiology Journals [editorial]. MBio. 2015; 6(4): e01236. PMID: 26265722, PMCID: PMC4542189, PII: mBio.01236-15, DOI: 10.1128/mBio.01236-15, ISSN: 2150-7511.

Stencel-Baerenwald J, Reiss K, Blaum BS, Colvin D, Li XN, Abel T, Boyd K, Stehle T, Dermody TS. Glycan engagement dictates hydrocephalus induction by serotype 1 reovirus. MBio. 2015; 6(2): e02356. PMID: 25736887, PMCID: PMC4358001, PII: mBio.02356-14, DOI: 10.1128/mBio.02356-14, ISSN: 2150-7511.

Fernández de Castro I, Zamora PF, Ooms L, Fernández JJ, Lai CM, Mainou BA, Dermody TS, Risco C. Correction for Fernández de Castro et al., Reovirus Forms Neo-Organelles for Progeny Particle Assembly within Reorganized Cell Membranes. MBio. 2015; 6(1): PMID: 25626908, PMCID: PMC4323419, PII: mBio.02529-14, DOI: 10.1128/mBio.02529-14, ISSN: 2150-7511.

Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, Crawford SE, Pruijssers AJ, Iskarpatyoti JA, Estes MK, Dermody TS, Ouyang W, Williams IR, Vijay-Kumar M, Gewirtz AT. Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18. Science. 2014 Nov 11/14/2014; 346(6211): 861-5. PMID: 25395539, PII: 346/6211/861, DOI: 10.1126/science.1256999, ISSN: 1095-9203.

Stencel-Baerenwald JE, Reiss K, Reiter DM, Stehle T, Dermody TS. The sweet spot: defining virus-sialic acid interactions. Nat. Rev. Microbiol [print-electronic]. 2014 Nov; 12(11): 739-49. PMID: 25263223, PII: nrmicro3346, DOI: 10.1038/nrmicro3346, ISSN: 1740-1534.

Ashbrook AW, Burrack KS, Silva LA, Montgomery SA, Heise MT, Morrison TE, Dermody TS. Residue 82 of the Chikungunya virus E2 attachment protein modulates viral dissemination and arthritis in mice. J. Virol [print-electronic]. 2014 Nov; 88(21): 12180-92. PMID: 25142598, PMCID: PMC4248890, PII: JVI.01672-14, DOI: 10.1128/JVI.01672-14, ISSN: 1098-5514.

Goubau D, Schlee M, Deddouche S, Pruijssers AJ, Zillinger T, Goldeck M, Schuberth C, Van der Veen AG, Fujimura T, Rehwinkel J, Iskarpatyoti JA, Barchet W, Ludwig J, Dermody TS, Hartmann G, Reis e Sousa C. Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates. Nature [print-electronic]. 2014 Oct 10/16/2014; 514(7522): 372-5. PMID: 25119032, PMCID: PMC4201573, PII: nature13590, DOI: 10.1038/nature13590, ISSN: 1476-4687.

Hood JL, Morabito MV, Martinez CR, Gilbert JA, Ferrick EA, Ayers GD, Chappell JD, Dermody TS, Emeson RB. Reovirus-mediated induction of ADAR1 (p150) minimally alters RNA editing patterns in discrete brain regions. Mol. Cell. Neurosci [print-electronic]. 2014 Jul; 61: 97-109. PMID: 24906008, PMCID: PMC4134954, PII: S1044-7431(14)00062-1, DOI: 10.1016/j.mcn.2014.06.001, ISSN: 1095-9327.

Konopka-Anstadt JL, Mainou BA, Sutherland DM, Sekine Y, Strittmatter SM, Dermody TS. The Nogo receptor NgR1 mediates infection by mammalian reovirus. Cell Host Microbe. 2014 Jun 6/11/2014; 15(6): 681-91. PMID: 24922571, PMCID: PMC4100558, PII: S1931-3128(14)00181-4, DOI: 10.1016/j.chom.2014.05.010, ISSN: 1934-6069.

Gonzalez-Hernandez MB, Liu T, Payne HC, Stencel-Baerenwald JE, Ikizler M, Yagita H, Dermody TS, Williams IR, Wobus CE. Efficient norovirus and reovirus replication in the mouse intestine requires microfold (M) cells. J. Virol [print-electronic]. 2014 Jun; 88(12): 6934-43. PMID: 24696493, PMCID: PMC4054386, PII: JVI.00204-14, DOI: 10.1128/JVI.00204-14, ISSN: 1098-5514.

Casadevall A, Dermody TS, Imperiale MJ, Sandri-Goldin RM, Shenk T. On the need for a national board to assess dual use research of concern [editorial]. J. Virol [print-electronic]. 2014 Jun; 88(12): 6535-7. PMID: 24696484, PMCID: PMC4054389, PII: JVI.00875-14, DOI: 10.1128/JVI.00875-14, ISSN: 1098-5514.

Dermody TS, Sandri-Goldin RM, Shenk T. Sequence changes associated with respiratory transmission of H7N1 influenza virus in mammals [editorial]. J. Virol [print-electronic]. 2014 Jun; 88(12): 6533-4. PMID: 24696481, PMCID: PMC4054340, PII: JVI.00886-14, DOI: 10.1128/JVI.00886-14, ISSN: 1098-5514.

Monteiro AC, Luissint AC, Sumagin R, Lai C, Vielmuth F, Wolf MF, Laur O, Reiss K, Spindler V, Stehle T, Dermody TS, Nusrat A, Parkos CA. Trans-dimerization of JAM-A regulates Rap2 and is mediated by a domain that is distinct from the cis-dimerization interface. Mol. Biol. Cell [print-electronic]. 2014 May; 25(10): 1574-85. PMID: 24672055, PMCID: PMC4019489, PII: mbc.E14-01-0018, DOI: 10.1091/mbc.E14-01-0018, ISSN: 1939-4586.

Silva LA, Khomandiak S, Ashbrook AW, Weller R, Heise MT, Morrison TE, Dermody TS. A single-amino-acid polymorphism in Chikungunya virus E2 glycoprotein influences glycosaminoglycan utilization. J. Virol [print-electronic]. 2014 Mar; 88(5): 2385-97. PMID: 24371059, PMCID: PMC3958064, PII: JVI.03116-13, DOI: 10.1128/JVI.03116-13, ISSN: 1098-5514.

Komoto S, Kawagishi T, Kobayashi T, Ikizler M, Iskarpatyoti J, Dermody TS, Taniguchi K. A plasmid-based reverse genetics system for mammalian orthoreoviruses driven by a plasmid-encoded T7 RNA polymerase. J. Virol. Methods [print-electronic]. 2014 Feb; 196: 36-9. PMID: 24183920, PII: S0166-0934(13)00427-8, DOI: 10.1016/j.jviromet.2013.10.023, ISSN: 1879-0984.

Fernandez de Castro, I., Zamora, P. F., Ooms, L. S., Fernandez, J. J., Lai, C. M., Mainou, B. A., Dermody, T. S., and C. Risco. Reovirus forms neoorganelles for progeny particle assembly within reorganized cell membranes. 2014.

Fites JS, Ramsey JP, Holden WM, Collier SP, Sutherland DM, Reinert LK, Gayek AS, Dermody TS, Aune TM, Oswald-Richter K, Rollins-Smith LA. The invasive chytrid fungus of amphibians paralyzes lymphocyte responses. Science. 2013 Oct 10/18/2013; 342(6156): 366-9. PMID: 24136969, PMCID: PMC3956111, PII: 342/6156/366, DOI: 10.1126/science.1243316, ISSN: 1095-9203.

Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA. JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function. Mol. Biol. Cell [print-electronic]. 2013 Sep; 24(18): 2849-60. PMID: 23885123, PMCID: PMC3771947, PII: mbc.E13-06-0298, DOI: 10.1091/mbc.E13-06-0298, ISSN: 1939-4586.

Boehme KW, Lai CM, Dermody TS. Mechanisms of reovirus bloodstream dissemination. Adv. Virus Res. 2013; 87: 1-35. PMID: 23809919, PMCID: PMC4603565, PII: B978-0-12-407698-3.00001-6, DOI: 10.1016/B978-0-12-407698-3.00001-6, ISSN: 1557-8399.

Lai CM, Mainou BA, Kim KS, Dermody TS. Directional release of reovirus from the apical surface of polarized endothelial cells. MBio. 2013; 4(2): e00049-13. PMID: 23572551, PMCID: PMC3622924, PII: mBio.00049-13, DOI: 10.1128/mBio.00049-13, ISSN: 2150-7511.

Bills JL, Davidson M, Dermody TS. Effectiveness of a clinical intervention for MD/PhD students re-entering medical school. Teach Learn Med. 2013; 25(1): 77-83. PMID: 23330899, DOI: 10.1080/10401334.2012.741539, ISSN: 1532-8015.

Mainou BA, Zamora PF, Ashbrook AW, Dorset DC, Kim KS, Dermody TS. Reovirus cell entry requires functional microtubules. MBio. 2013; 4(4): PMID: 23820395, PMCID: PMC3705452, PII: mBio.00405-13, DOI: 10.1128/mBio.00405-13, ISSN: 2150-7511.

Mainou BA, Dermody TS. In search of cathepsins: how reovirus enters host cells. DNA Cell Biol [print-electronic]. 2012 Dec; 31(12): 1646-9. PMID: 23134451, PMCID: PMC3505829, DOI: 10.1089/dna.2012.1868, ISSN: 1557-7430.

Frierson JM, Pruijssers AJ, Konopka JL, Reiter DM, Abel TW, Stehle T, Dermody TS. Utilization of sialylated glycans as coreceptors enhances the neurovirulence of serotype 3 reovirus. J. Virol [print-electronic]. 2012 Dec; 86(24): 13164-73. PMID: 23035227, PMCID: PMC3503066, PII: JVI.01822-12, DOI: 10.1128/JVI.01822-12, ISSN: 1098-5514.

Iskarpatyoti JA, Morse EA, McClung RP, Ikizler M, Wetzel JD, Contractor N, Dermody TS. Serotype-specific differences in inhibition of reovirus infectivity by human-milk glycans are determined by viral attachment protein s1. Virology [print-electronic]. 2012 Nov 11/25/2012; 433(2): 489-97. PMID: 22999096, PII: S0042-6822(12)00417-5, DOI: 10.1016/j.virol.2012.08.036, ISSN: 1096-0341.

Ooms LS, Jerome WG, Dermody TS, Chappell JD. Reovirus replication protein µ2 influences cell tropism by promoting particle assembly within viral inclusions. J. Virol [print-electronic]. 2012 Oct; 86(20): 10979-87. PMID: 22837214, PMCID: PMC3457141, PII: JVI.01172-12, DOI: 10.1128/JVI.01172-12, ISSN: 1098-5514.

Bokiej M, Ogden KM, Ikizler M, Reiter DM, Stehle T, Dermody TS. Optimum length and flexibility of reovirus attachment protein s1 are required for efficient viral infection. J. Virol [print-electronic]. 2012 Oct; 86(19): 10270-80. PMID: 22811534, PMCID: PMC3457286, PII: JVI.01338-12, DOI: 10.1128/JVI.01338-12, ISSN: 1098-5514.

Iskarpatyoti JA, Willis JZ, Guan J, Morse EA, Ikizler M, Wetzel JD, Dermody TS, Contractor N. A rapid, automated approach for quantitation of rotavirus and reovirus infectivity. J. Virol. Methods [print-electronic]. 2012 Sep; 184(1-2): 1-7. PMID: 22465252, PII: S0166-0934(12)00086-9, DOI: 10.1016/j.jviromet.2012.03.018, ISSN: 1879-0984.

Mainou BA, Dermody TS. Transport to late endosomes is required for efficient reovirus infection. J. Virol [print-electronic]. 2012 Aug; 86(16): 8346-58. PMID: 22674975, PMCID: PMC3421701, PII: JVI.00100-12, DOI: 10.1128/JVI.00100-12, ISSN: 1098-5514.

Doyle JD, Danthi P, Kendall EA, Ooms LS, Wetzel JD, Dermody TS. Molecular determinants of proteolytic disassembly of the reovirus outer capsid. J. Biol. Chem [print-electronic]. 2012 Mar 3/9/2012; 287(11): 8029-38. PMID: 22253447, PMCID: PMC3318753, PII: M111.334854, DOI: 10.1074/jbc.M111.334854, ISSN: 1083-351X.

Boehme KW, Frierson JM, Konopka JL, Kobayashi T, Dermody TS. The reovirus sigma1s protein is a determinant of hematogenous but not neural virus dissemination in mice. J. Virol [print-electronic]. 2011 Nov; 85(22): 11781-90. PMID: 21917967, PMCID: PMC3209282, PII: JVI.02289-10, DOI: 10.1128/JVI.02289-10, ISSN: 1098-5514.

Boehme KW, Ikizler M, Kobayashi T, Dermody TS. Reverse genetics for mammalian reovirus. Methods [print-electronic]. 2011 Oct; 55(2): 109-13. PMID: 21798351, PMCID: PMC3208765, PII: S1046-2023(11)00128-9, DOI: 10.1016/j.ymeth.2011.07.002, ISSN: 1095-9130.

Dosa S, Castellanos K, Bacsa S, Gagyi E, Kovacs SK, Valyi-Nagy K, Shukla D, Dermody TS, Valyi-Nagy T. Chronic progressive deficits in neuron size, density and number in the trigeminal ganglia of mice latently infected with herpes simplex virus. Brain Pathol [print-electronic]. 2011 Sep; 21(5): 583-93. PMID: 21371157, PMCID: PMC3125479, DOI: 10.1111/j.1750-3639.2011.00485.x, ISSN: 1750-3639.

Lindquist ME, Mainou BA, Dermody TS, Crowe JE. Activation of protein kinase R is required for induction of stress granules by respiratory syncytial virus but dispensable for viral replication. Virology [print-electronic]. 2011 Apr 4/25/2011; 413(1): 103-10. PMID: 21377708, PMCID: PMC3072468, PII: S0042-6822(11)00070-5, DOI: 10.1016/j.virol.2011.02.009, ISSN: 1096-0341.

Mainou BA, Dermody TS. Src kinase mediates productive endocytic sorting of reovirus during cell entry. J. Virol [print-electronic]. 2011 Apr; 85(7): 3203-13. PMID: 21248042, PMCID: PMC3067878, PII: JVI.02056-10, DOI: 10.1128/JVI.02056-10, ISSN: 1098-5514.

Sen A, Pruijssers AJ, Dermody TS, García-Sastre A, Greenberg HB. The early interferon response to rotavirus is regulated by PKR and depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3. J. Virol [print-electronic]. 2011 Apr; 85(8): 3717-32. PMID: 21307186, PMCID: PMC3126121, PII: JVI.02634-10, DOI: 10.1128/JVI.02634-10, ISSN: 1098-5514.

Ciampa EJ, Hunt AA, Arneson KO, Mordes DA, Oldham WM, Vin Woo K, Owens DA, Cannon MD, Dermody TS. A workshop on leadership for MD/PhD students. Med Educ Online [print-electronic]. 2011; 16: PMID: 21841905, PMCID: PMC3154680, PII: MEO-16-7075, DOI: 10.3402/meo.v16i0.7075, ISSN: 1087-2981.

Ooms LS, Kobayashi T, Dermody TS, Chappell JD. A post-entry step in the mammalian orthoreovirus replication cycle is a determinant of cell tropism. J. Biol. Chem [print-electronic]. 2010 Dec 12/31/2010; 285(53): 41604-13. PMID: 20978124, PMCID: PMC3009888, PII: M110.176255, DOI: 10.1074/jbc.M110.176255, ISSN: 1083-351X.

Ciampa EJ, Hunt AA, Dermody TS. Leadership can and should be taught [letter]. Acad Med. 2010 Dec; 85(12): 1814. PMID: 21107028, PII: 00001888-201012000-00007, DOI: 10.1097/ACM.0b013e3181fa3a69, ISSN: 1938-808X.

Trask SD, Taraporewala ZF, Boehme KW, Dermody TS, Patton JT. Dual selection mechanisms drive efficient single-gene reverse genetics for rotavirus. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2010 Oct 10/26/2010; 107(43): 18652-7. PMID: 20937889, PMCID: PMC2972929, PII: 1011948107, DOI: 10.1073/pnas.1011948107, ISSN: 1091-6490.

Esbenshade JC, Flack EC, Kantola S, Wills ML, Dodd DA, Dermody TS. A four-week-old infant with an intracardiac mass. Pediatr. Infect. Dis. J. 2010 Sep; 29(9): 889-93. PMID: 20720474, PII: 00006454-201009000-00029, DOI: 10.1097/INF.0b013e3181dd1abe, ISSN: 1532-0987.

Holm GH, Pruijssers AJ, Li L, Danthi P, Sherry B, Dermody TS. Interferon regulatory factor 3 attenuates reovirus myocarditis and contributes to viral clearance. J. Virol [print-electronic]. 2010 Jul; 84(14): 6900-8. PMID: 20463082, PMCID: PMC2898218, PII: JVI.01742-09, DOI: 10.1128/JVI.01742-09, ISSN: 1098-5514.

Kobayashi T, Ooms LS, Ikizler M, Chappell JD, Dermody TS. An improved reverse genetics system for mammalian orthoreoviruses. Virology [print-electronic]. 2010 Mar 3/15/2010; 398(2): 194-200. PMID: 20042210, PMCID: PMC2823833, PII: S0042-6822(09)00773-9, DOI: 10.1016/j.virol.2009.11.037, ISSN: 1096-0341.

Danthi P, Pruijssers AJ, Berger AK, Holm GH, Zinkel SS, Dermody TS. Bid regulates the pathogenesis of neurotropic reovirus. PLoS Pathog. 2010; 6: e1000980. PMID: 20617182, PMCID: PMC2895667, DOI: 10.1371/journal.ppat.1000980, ISSN: 1553-7374.

Danthi P, Guglielmi KM, Kirchner E, Mainou B, Stehle T, Dermody TS. From touchdown to transcription: the reovirus cell entry pathway. Curr. Top. Microbiol. Immunol. 2010; 343: 91-119. PMID: 20397070, DOI: 10.1007/82_2010_32, ISSN: 0070-217X.

Boehme KW, Guglielmi KM, Dermody TS. Reovirus nonstructural protein sigma1s is required for establishment of viremia and systemic dissemination. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2009 Nov 11/24/2009; 106(47): 19986-91. PMID: 19897716, PMCID: PMC2774258, PII: 0907412106, DOI: 10.1073/pnas.0907412106, ISSN: 1091-6490.

Dermody TS, Kirchner E, Guglielmi KM, Stehle T. Immunoglobulin superfamily virus receptors and the evolution of adaptive immunity. PLoS Pathog [print-electronic]. 2009 Nov; 5(11): e1000481. PMID: 19956667, PMCID: PMC2777377, DOI: 10.1371/journal.ppat.1000481, ISSN: 1553-7374.

Johnson EM, Doyle JD, Wetzel JD, McClung RP, Katunuma N, Chappell JD, Washington MK, Dermody TS. Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. J. Virol [print-electronic]. 2009 Oct; 83(19): 9630-40. PMID: 19640986, PMCID: PMC2748054, PII: JVI.01095-09, DOI: 10.1128/JVI.01095-09, ISSN: 1098-5514.

Enquist LW, . Virology in the 21st century. J. Virol [print-electronic]. 2009 Jun; 83(11): 5296-308. PMID: 19297504, PMCID: PMC2681991, PII: JVI.00151-09, DOI: 10.1128/JVI.00151-09, ISSN: 1098-5514.

Kobayashi T, Ooms LS, Chappell JD, Dermody TS. Identification of functional domains in reovirus replication proteins muNS and mu2. J. Virol [print-electronic]. 2009 Apr; 83(7): 2892-906. PMID: 19176625, PMCID: PMC2655549, PII: JVI.01495-08, DOI: 10.1128/JVI.01495-08, ISSN: 1098-5514.

Zurney J, Kobayashi T, Holm GH, Dermody TS, Sherry B. Reovirus mu2 protein inhibits interferon signaling through a novel mechanism involving nuclear accumulation of interferon regulatory factor 9. J. Virol [print-electronic]. 2009 Mar; 83(5): 2178-87. PMID: 19109390, PMCID: PMC2643726, PII: JVI.01787-08, DOI: 10.1128/JVI.01787-08, ISSN: 1098-5514.

Cseke G, Maginnis MS, Cox RG, Tollefson SJ, Podsiad AB, Wright DW, Dermody TS, Williams JV. Integrin alphavbeta1 promotes infection by human metapneumovirus. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2009 Feb 2/3/2009; 106(5): 1566-71. PMID: 19164533, PMCID: PMC2629439, PII: 0801433106, DOI: 10.1073/pnas.0801433106, ISSN: 1091-6490.

Antar AA, Konopka JL, Campbell JA, Henry RA, Perdigoto AL, Carter BD, Pozzi A, Abel TW, Dermody TS. Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Cell Host Microbe. 2009 Jan 1/22/2009; 5(1): 59-71. PMID: 19154988, PMCID: PMC2642927, PII: S1931-3128(08)00398-3, DOI: 10.1016/j.chom.2008.12.001, ISSN: 1934-6069.

Danthi P, Coffey CM, Parker JS, Abel TW, Dermody TS. Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domain. PLoS Pathog [print-electronic]. 2008 Dec; 4(12): e1000248. PMID: 19112493, PMCID: PMC2600812, DOI: 10.1371/journal.ppat.1000248, ISSN: 1553-7374.

Kirchner E, Guglielmi KM, Strauss HM, Dermody TS, Stehle T. Structure of reovirus sigma1 in complex with its receptor junctional adhesion molecule-A. PLoS Pathog [print-electronic]. 2008 Dec; 4(12): e1000235. PMID: 19079583, PMCID: PMC2588538, DOI: 10.1371/journal.ppat.1000235, ISSN: 1553-7374.

Schagen FH, Graat HC, Carette JE, Vellinga J, van Geer MA, Hoeben RC, Dermody TS, van Beusechem VW. Replacement of native adenovirus receptor-binding sites with a new attachment moiety diminishes hepatic tropism and enhances bioavailability in mice. Hum. Gene Ther. 2008 Aug; 19(8): 783-94. PMID: 18627267, PMCID: PMC2736798, DOI: 10.1089/hum.2007.133, ISSN: 1557-7422.

Kato H, Takeuchi O, Mikamo-Satoh E, Hirai R, Kawai T, Matsushita K, Hiiragi A, Dermody TS, Fujita T, Akira S. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J. Exp. Med. 2008 Jul 7/7/2008; 205(7): 1601-10. PMID: 18591409, PMCID: PMC2442638, PII: jem.20080091, DOI: 10.1084/jem.20080091, ISSN: 1540-9538.

Vedula SR, Lim TS, Kirchner E, Guglielmi KM, Dermody TS, Stehle T, Hunziker W, Lim CT. A comparative molecular force spectroscopy study of homophilic JAM-A interactions and JAM-A interactions with reovirus attachment protein sigma1. J. Mol. Recognit. 2008 Jul; 21(4): 210-6. PMID: 18446885, DOI: 10.1002/jmr.886, ISSN: 0952-3499.

Excoffon KJ, Guglielmi KM, Wetzel JD, Gansemer ND, Campbell JA, Dermody TS, Zabner J. Reovirus preferentially infects the basolateral surface and is released from the apical surface of polarized human respiratory epithelial cells. J. Infect. Dis. 2008 Apr 4/15/2008; 197(8): 1189-97. PMID: 18419529, PMCID: PMC2736797, DOI: 10.1086/529515, ISSN: 0022-1899.

Maginnis MS, Mainou BA, Derdowski A, Johnson EM, Zent R, Dermody TS. NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry. J. Virol [print-electronic]. 2008 Apr; 82(7): 3181-91. PMID: 18216114, PMCID: PMC2268482, PII: JVI.01612-07, DOI: 10.1128/JVI.01612-07, ISSN: 1098-5514.

Danthi P, Kobayashi T, Holm GH, Hansberger MW, Abel TW, Dermody TS. Reovirus apoptosis and virulence are regulated by host cell membrane penetration efficiency. J. Virol [print-electronic]. 2008 Jan; 82(1): 161-72. PMID: 17959662, PMCID: PMC2224352, PII: JVI.01739-07, DOI: 10.1128/JVI.01739-07, ISSN: 1098-5514.

Laukoetter MG, Nava P, Lee WY, Severson EA, Capaldo CT, Babbin BA, Williams IR, Koval M, Peatman E, Campbell JA, Dermody TS, Nusrat A, Parkos CA. JAM-A regulates permeability and inflammation in the intestine in vivo. J. Exp. Med [print-electronic]. 2007 Dec 12/24/2007; 204(13): 3067-76. PMID: 18039951, PMCID: PMC2150975, PII: jem.20071416, DOI: 10.1084/jem.20071416, ISSN: 1540-9538.

Holm GH, Zurney J, Tumilasci V, Leveille S, Danthi P, Hiscott J, Sherry B, Dermody TS. Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3. J. Biol. Chem [print-electronic]. 2007 Jul 7/27/2007; 282(30): 21953-61. PMID: 17540767, PII: M702112200, DOI: 10.1074/jbc.M702112200, ISSN: 0021-9258.

Guglielmi KM, Kirchner E, Holm GH, Stehle T, Dermody TS. Reovirus binding determinants in junctional adhesion molecule-A. J. Biol. Chem [print-electronic]. 2007 Jun 6/15/2007; 282(24): 17930-40. PMID: 17452315, PII: M702180200, DOI: 10.1074/jbc.M702180200, ISSN: 0021-9258.

Johansson C, Wetzel JD, He J, Mikacenic C, Dermody TS, Kelsall BL. Type I interferons produced by hematopoietic cells protect mice against lethal infection by mammalian reovirus. J. Exp. Med [print-electronic]. 2007 Jun 6/11/2007; 204(6): 1349-58. PMID: 17502662, PMCID: PMC2118611, PII: jem.20061587, DOI: 10.1084/jem.20061587, ISSN: 0022-1007.

Kobayashi T, Antar AA, Boehme KW, Danthi P, Eby EA, Guglielmi KM, Holm GH, Johnson EM, Maginnis MS, Naik S, Skelton WB, Wetzel JD, Wilson GJ, Chappell JD, Dermody TS. A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe. 2007 Apr 4/19/2007; 1(2): 147-57. PMID: 18005692, PMCID: PMC2034303, PII: S1931-3128(07)00042-X, DOI: 10.1016/j.chom.2007.03.003, ISSN: 1934-6069.

Schelling P, Guglielmi KM, Kirchner E, Paetzold B, Dermody TS, Stehle T. The reovirus sigma1 aspartic acid sandwich: a trimerization motif poised for conformational change. J. Biol. Chem [print-electronic]. 2007 Apr 4/13/2007; 282(15): 11582-9. PMID: 17303562, PII: M610805200, DOI: 10.1074/jbc.M610805200, ISSN: 0021-9258.

Hansberger MW, Campbell JA, Danthi P, Arrate P, Pennington KN, Marcu KB, Ballard DW, Dermody TS. IkappaB kinase subunits alpha and gamma are required for activation of NF-kappaB and induction of apoptosis by mammalian reovirus. J. Virol [print-electronic]. 2007 Feb; 81(3): 1360-71. PMID: 17121808, PMCID: PMC1797491, PII: JVI.01860-06, DOI: 10.1128/JVI.01860-06, ISSN: 0022-538X.

Kobayashi T, Antar AAR, Boehme KW, Danthi P, Eby EA, Guglielmi KM, Holm GH, Johnson EM, Maginnis MS, Naik S, Skelton WB, Wetzel JD, Wilson GJ, Chappell JD, Dermody TS. A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe. 2007; 1((2)): 147-57.

Stone GP, Wetzel JD, Russ PK, Dermody TS, Haselton FR. Autonomous reovirus strain classification using filament-coupled antibodies. Ann Biomed Eng [print-electronic]. 2006 Nov; 34(11): 1778-85. PMID: 17031592, PMCID: PMC1705476, DOI: 10.1007/s10439-006-9199-0, ISSN: 0090-6964.

Kobayashi T, Chappell JD, Danthi P, Dermody TS. Gene-specific inhibition of reovirus replication by RNA interference. J. Virol. 2006 Sep; 80(18): 9053-63. PMID: 16940517, PMCID: PMC1563907, PII: 80/18/9053, DOI: 10.1128/JVI.00276-06, ISSN: 0022-538X.

Shukla D, Scanlan PM, Tiwari V, Sheth V, Clement C, Guzman-Hartman G, Dermody TS, Valyi-Nagy T. Expression of nectin-1 in normal and herpes simplex virus type 1-infected murine brain. Appl. Immunohistochem. Mol. Morphol. 2006 Sep; 14(3): 341-7. PMID: 16932027, PII: 00129039-200609000-00014, ISSN: 1541-2016.

Fleming GA, Frangoul H, Dermody TS, Halasa N. A cord blood transplant recipient with Mycobacterium mucogenicum central venous catheter infection after infusion of tap water. Pediatr. Infect. Dis. J. 2006 Jun; 25(6): 567-9. PMID: 16732163, PII: 00006454-200606000-00023, DOI: 10.1097/01.inf.0000219406.06431.67, ISSN: 0891-3668.

Schagen FH, Wensveen FM, Carette JE, Dermody TS, Gerritsen WR, van Beusechem VW. Genetic targeting of adenovirus vectors using a reovirus sigma1-based attachment protein. Mol. Ther [print-electronic]. 2006 May; 13(5): 997-1005. PMID: 16515889, PII: S1525-0016(05)01717-X, DOI: 10.1016/j.ymthe.2005.11.019, ISSN: 1525-0016.

Empig C, Kenner JR, Perret-Gentil M, Youree BE, Bell E, Chen A, Gurwith M, Higgins K, Lock M, Rice AD, Schriewer J, Sinangil F, White E, Buller RM, Dermody TS, Isaacs SN, Moyer RW. Highly attenuated smallpox vaccine protects rabbits and mice against pathogenic orthopoxvirus challenge. Vaccine. 2006 Apr 4/24/2006; 24(17): 3686-94. PMID: 16430997, PII: S0264-410X(05)00412-3, DOI: 10.1016/j.vaccine.2005.03.029, ISSN: 0264-410X.

Wetzel JD, Barton ES, Chappell JD, Baer GS, Mochow-Grundy M, Rodgers SE, Shyr Y, Powers AC, Thomas JW, Dermody TS. Reovirus delays diabetes onset but does not prevent insulitis in nonobese diabetic mice. J. Virol. 2006 Mar; 80(6): 3078-82. PMID: 16501117, PMCID: PMC1395416, PII: 80/6/3078, DOI: 10.1128/JVI.80.6.3078-3082.2006, ISSN: 0022-538X.

Maginnis MS, Forrest JC, Kopecky-Bromberg SA, Dickeson SK, Santoro SA, Zutter MM, Nemerow GR, Bergelson JM, Dermody TS. Beta1 integrin mediates internalization of mammalian reovirus. J. Virol. 2006 Mar; 80(6): 2760-70. PMID: 16501085, PMCID: PMC1395463, PII: 80/6/2760, DOI: 10.1128/JVI.80.6.2760-2770.2006, ISSN: 0022-538X.

Huang IC, Bosch BJ, Li F, Li W, Lee KH, Ghiran S, Vasilieva N, Dermody TS, Harrison SC, Dormitzer PR, Farzan M, Rottier PJ, Choe H. SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. J. Biol. Chem [print-electronic]. 2006 Feb 2/10/2006; 281(6): 3198-203. PMID: 16339146, PII: M508381200, DOI: 10.1074/jbc.M508381200, ISSN: 0021-9258.

Danthi P, Hansberger MW, Campbell JA, Forrest JC, Dermody TS. JAM-A-independent, antibody-mediated uptake of reovirus into cells leads to apoptosis. J. Virol. 2006 Feb; 80(3): 1261-70. PMID: 16415003, PMCID: PMC1346953, PII: 80/3/1261, DOI: 10.1128/JVI.80.3.1261-1270.2006, ISSN: 0022-538X.

O'Donnell SM, Holm GH, Pierce JM, Tian B, Watson MJ, Chari RS, Ballard DW, Brasier AR, Dermody TS. Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus. J. Virol. 2006 Feb; 80(3): 1077-86. PMID: 16414985, PMCID: PMC1346919, PII: 80/3/1077, DOI: 10.1128/JVI.80.3.1077-1086.2006, ISSN: 0022-538X.

Guglielmi KM, Johnson EM, Stehle T, Dermody TS. Attachment and cell entry of mammalian orthoreovirus. Curr. Top. Microbiol. Immunol. 2006; 309: 1-38. PMID: 16909895, ISSN: 0070-217X.

Farone AL, O'Donnell SM, Brooks CS, Young KM, Pierce JM, Wetzel JD, Dermody TS, Farone MB. Reovirus strain-dependent inflammatory cytokine responses and replication patterns in a human monocyte cell line. Viral Immunol. 2006; 19(3): 546-57. PMID: 16987072, DOI: 10.1089/vim.2006.19.546, ISSN: 0882-8245.

Clark KM, Wetzel JD, Gu Y, Ebert DH, McAbee SA, Stoneman EK, Baer GS, Zhu Y, Wilson GJ, Prasad BV, Dermody TS. Reovirus variants selected for resistance to ammonium chloride have mutations in viral outer-capsid protein sigma3. J. Virol. 2006 Jan; 80(2): 671-81. PMID: 16378970, PMCID: PMC1346852, PII: 80/2/671, DOI: 10.1128/JVI.80.2.671-681.2006, ISSN: 0022-538X.

VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D. Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells. J. Virol. 2005 Sep; 79(18): 11598-606. PMID: 16140737, PMCID: PMC1212620, PII: 79/18/11598, DOI: 10.1128/JVI.79.18.11598-11606.2005, ISSN: 0022-538X.

O'Donnell SM, Hansberger MW, Connolly JL, Chappell JD, Watson MJ, Pierce JM, Wetzel JD, Han W, Barton ES, Forrest JC, Valyi-Nagy T, Yull FE, Blackwell TS, Rottman JN, Sherry B, Dermody TS. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J. Clin. Invest [print-electronic]. 2005 Sep; 115(9): 2341-50. PMID: 16100570, PMCID: PMC1184036, DOI: 10.1172/JCI22428, ISSN: 0021-9738.

Campbell JA, Schelling P, Wetzel JD, Johnson EM, Forrest JC, Wilson GA, Aurrand-Lions M, Imhof BA, Stehle T, Dermody TS. Junctional adhesion molecule a serves as a receptor for prototype and field-isolate strains of mammalian reovirus. J. Virol. 2005 Jul; 79(13): 7967-78. PMID: 15956543, PMCID: PMC1143703, PII: 79/13/7967, DOI: 10.1128/JVI.79.13.7967-7978.2005, ISSN: 0022-538X.

Valyi-Nagy T, Dermody TS. Role of oxidative damage in the pathogenesis of viral infections of the nervous system. Histol. Histopathol. 2005 Jul; 20(3): 957-67. PMID: 15944946, ISSN: 0213-3911.

Tai JH, Williams JV, Edwards KM, Wright PF, Crowe JE, Dermody TS. Prevalence of reovirus-specific antibodies in young children in Nashville, Tennessee. J. Infect. Dis [print-electronic]. 2005 Apr 4/15/2005; 191(8): 1221-4. PMID: 15776366, PII: JID33615, DOI: 10.1086/428911, ISSN: 0022-1899.

Dong X, Li H, Derdowski A, Ding L, Burnett A, Chen X, Peters TR, Dermody TS, Woodruff E, Wang JJ, Spearman P. AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly. Cell. 2005 Mar 3/11/2005; 120(5): 663-74. PMID: 15766529, PII: S0092-8674(04)01248-6, DOI: 10.1016/j.cell.2004.12.023, ISSN: 0092-8674.

Fleeton M, Contractor N, Leon F, He J, Wetzel D, Dermody T, Iwasaki A, Kelsall B. Involvement of dendritic cell subsets in the induction of oral tolerance and immunity. Ann. N. Y. Acad. Sci. 2004 Dec; 1029: 60-5. PMID: 15681744, PII: 1029/1/60, DOI: 10.1196/annals.1309.008, ISSN: 0077-8923.

Brockway SM, Lu XT, Peters TR, Dermody TS, Denison MR. Intracellular localization and protein interactions of the gene 1 protein p28 during mouse hepatitis virus replication. J. Virol. 2004 Nov; 78(21): 11551-62. PMID: 15479796, PMCID: PMC523235, PII: 78/21/11551, DOI: 10.1128/JVI.78.21.11551-11562.2004, ISSN: 0022-538X.

Valyi-Nagy T, Sheth V, Clement C, Tiwari V, Scanlan P, Kavouras JH, Leach L, Guzman-Hartman G, Dermody TS, Shukla D. Herpes simplex virus entry receptor nectin-1 is widely expressed in the murine eye. Curr. Eye Res. 2004 Oct; 29(4-5): 303-9. PMID: 15590476, PII: VL8HQX8UQ2LH9WH2, DOI: 10.1080/02713680490516756, ISSN: 0271-3683.

Fleeton MN, Contractor N, Leon F, Wetzel JD, Dermody TS, Kelsall BL. Peyer's patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice. J. Exp. Med. 2004 Jul 7/19/2004; 200(2): 235-45. PMID: 15263030, PMCID: PMC2212021, PII: jem.20041132, DOI: 10.1084/jem.20041132, ISSN: 0022-1007.

Shankar S, Choi JK, Dermody TS, Head DR, Bunin N, Iannone R. Pulmonary hypertension complicating bone marrow transplantation for idiopathic myelofibrosis. J. Pediatr. Hematol. Oncol. 2004 Jun; 26(6): 393-7. PMID: 15167356, PII: 00043426-200406000-00013, ISSN: 1077-4114.

Cavalli A, Prota AE, Stehle T, Dermody TS, Recanatini M, Folkers G, Scapozza L. A molecular dynamics study of reovirus attachment protein sigma1 reveals conformational changes in sigma1 structure. Biophys. J. 2004 Jun; 86(6): 3423-31. PMID: 15189844, PMCID: PMC1304249, PII: S0006-3495(04)74388-X, DOI: 10.1529/biophysj.103.030825, ISSN: 0006-3495.

Tyler KL, Barton ES, Ibach ML, Robinson C, Campbell JA, O'Donnell SM, Valyi-Nagy T, Clarke P, Wetzel JD, Dermody TS. Isolation and molecular characterization of a novel type 3 reovirus from a child with meningitis. J. Infect. Dis [print-electronic]. 2004 May 5/1/2004; 189(9): 1664-75. PMID: 15116303, PII: JID31712, DOI: 10.1086/383129, ISSN: 0022-1899.

Mercier GT, Campbell JA, Chappell JD, Stehle T, Dermody TS, Barry MA. A chimeric adenovirus vector encoding reovirus attachment protein sigma1 targets cells expressing junctional adhesion molecule 1. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2004 Apr 4/20/2004; 101(16): 6188-93. PMID: 15079060, PMCID: PMC395944, PII: 0400542101, DOI: 10.1073/pnas.0400542101, ISSN: 0027-8424.

Ebert DH, Kopecky-Bromberg SA, Dermody TS. Cathepsin B Is Inhibited in Mutant Cells Selected during Persistent Reovirus Infection. J. Biol. Chem [print-electronic]. 2004 Jan 1/30/2004; 279(5): 3837-51. PMID: 14585834, PII: M310048200, DOI: 10.1074/jbc.M310048200, ISSN: 0021-9258.

Stehle T, Dermody TS. Structural similarities in the cellular receptors used by adenovirus and reovirus. Viral Immunol. 2004; 17(2): 129-43. PMID: 15279694, DOI: 10.1089/0882824041310621, ISSN: 0882-8245.

Forrest JC, Campbell JA, Schelling P, Stehle T, Dermody TS. Structure-function analysis of reovirus binding to junctional adhesion molecule 1. Implications for the mechanism of reovirus attachment. J. Biol. Chem [print-electronic]. 2003 Nov 11/28/2003; 278(48): 48434-44. PMID: 12966102, PII: M305649200, DOI: 10.1074/jbc.M305649200, ISSN: 0021-9258.

Halasa NB, Whitlock JA, McCurley TL, Smith JA, Zhu Q, Ochs H, Dermody TS, Crowe JE. Fatal hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus infection in a patient with a novel mutation in the signaling lymphocytic activation molecule-associated protein. Clin. Infect. Dis [print-electronic]. 2003 Nov 11/15/2003; 37(10): e136-41. PMID: 14583885, PII: CID31173, DOI: 10.1086/379126, ISSN: 1537-6591.

Forrest JC, Dermody TS. Reovirus receptors and pathogenesis. J. Virol. 2003 Sep; 77(17): 9109-15. PMID: 12915527, PMCID: PMC187431, ISSN: 0022-538X.

O'Donnell SM, Hansberger MW, Dermody TS. Viral and cellular determinants of apoptosis induced by mammalian reovirus. Int. Rev. Immunol. 2003 Sep; 22(5-6): 477-503. PMID: 12959755, PII: 99PATBR9BAJWX9BW, ISSN: 0883-0185.

Barton ES, Youree BE, Ebert DH, Forrest JC, Connolly JL, Valyi-Nagy T, Washington K, Wetzel JD, Dermody TS. Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease. J. Clin. Invest. 2003 Jun; 111(12): 1823-33. PMID: 12813018, PMCID: PMC161418, DOI: 10.1172/JCI16303, ISSN: 0021-9738.

Becker MM, Peters TR, Dermody TS. Reovirus sigma NS and mu NS proteins form cytoplasmic inclusion structures in the absence of viral infection. J. Virol. 2003 May; 77(10): 5948-63. PMID: 12719587, PMCID: PMC154006, ISSN: 0022-538X.

Prota AE, Campbell JA, Schelling P, Forrest JC, Watson MJ, Peters TR, Aurrand-Lions M, Imhof BA, Dermody TS, Stehle T. Crystal structure of human junctional adhesion molecule 1: implications for reovirus binding. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Apr 4/29/2003; 100(9): 5366-71. PMID: 12697893, PMCID: PMC404559, PII: 0937718100, DOI: 10.1073/pnas.0937718100, ISSN: 0027-8424.

Stehle T, Dermody TS. Structural evidence for common functions and ancestry of the reovirus and adenovirus attachment proteins. Rev. Med. Virol. 2003 Mar; 13(2): 123-32. PMID: 12627395, DOI: 10.1002/rmv.379, ISSN: 1052-9276.

Stewart PL, Dermody TS, Nemerow GR. Structural basis of nonenveloped virus cell entry. Adv. Protein Chem. 2003; 64: 455-91. PMID: 13677056, ISSN: 0065-3233.

Wilson GJ, Nason EL, Hardy CS, Ebert DH, Wetzel JD, Venkataram Prasad BV, Dermody TS. A single mutation in the carboxy terminus of reovirus outer-capsid protein sigma 3 confers enhanced kinetics of sigma 3 proteolysis, resistance to inhibitors of viral disassembly, and alterations in sigma 3 structure. J. Virol. 2002 Oct; 76(19): 9832-43. PMID: 12208961, PMCID: PMC136532, ISSN: 0022-538X.

Milatovic D, Zhang Y, Olson SJ, Montine KS, Roberts LJ, Morrow JD, Montine TJ, Dermody TS, Valyi-Nagy T. Herpes simplex virus type 1 encephalitis is associated with elevated levels of F2-isoprostanes and F4-neuroprostanes. J. Neurovirol. 2002 Aug; 8(4): 295-305. PMID: 12161814, DOI: 10.1080/13550280290100743, ISSN: 1355-0284.

Ebert DH, Deussing J, Peters C, Dermody TS. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J. Biol. Chem [print-electronic]. 2002 Jul 7/5/2002; 277(27): 24609-17. PMID: 11986312, PII: M201107200, DOI: 10.1074/jbc.M201107200, ISSN: 0021-9258.

Leary TP, Erker JC, Chalmers ML, Wetzel JD, Desai SM, Mushahwar IK, Dermody TS. Detection of reovirus by reverse transcription-polymerase chain reaction using primers corresponding to conserved regions of the viral L1 genome segment. J. Virol. Methods. 2002 Jul; 104(2): 161-5. PMID: 12088825, PII: S0166093402000587, ISSN: 0166-0934.

Filippova M, Song H, Connolly JL, Dermody TS, Duerksen-Hughes PJ. The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis. J. Biol. Chem [print-electronic]. 2002 Jun 6/14/2002; 277(24): 21730-9. PMID: 11934887, PII: M200113200, DOI: 10.1074/jbc.M200113200, ISSN: 0021-9258.

Leary TP, Erker JC, Chalmers ML, Cruz AT, Wetzel JD, Desai SM, Mushahwar IK, Dermody TS. Detection of mammalian reovirus RNA by using reverse transcription-PCR: sequence diversity within the lambda3-encoding L1 gene. J. Clin. Microbiol. 2002 Apr; 40(4): 1368-75. PMID: 11923358, PMCID: PMC140344, ISSN: 0095-1137.

Connolly JL, Dermody TS. Virion disassembly is required for apoptosis induced by reovirus. J. Virol. 2002 Feb; 76(4): 1632-41. PMID: 11799158, PMCID: PMC135877, ISSN: 0022-538X.

Chappell JD, Prota AE, Dermody TS, Stehle T. Crystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiber. EMBO J. 2002 Jan 1/15/2002; 21(1-2): 1-11. PMID: 11782420, PMCID: PMC125343, DOI: 10.1093/emboj/21.1.1, ISSN: 0261-4189.

Barton ES, Chappell JD, Connolly JL, Forrest JC, Dermody TS. Reovirus receptors and apoptosis. Virology. 2001 Nov 11/25/2001; 290(2): 173-80. PMID: 11883182, PII: S0042-6822(01)91160-2, DOI: 10.1006/viro.2001.1160, ISSN: 0042-6822.

Poggioli GJ, Dermody TS, Tyler KL. Reovirus-induced sigma1s-dependent G(2)/M phase cell cycle arrest is associated with inhibition of p34(cdc2). J. Virol. 2001 Aug; 75(16): 7429-34. PMID: 11462015, PMCID: PMC114978, DOI: 10.1128/JVI.75.16.7429-7434.2001, ISSN: 0022-538X.

Nason EL, Wetzel JD, Mukherjee SK, Barton ES, Prasad BV, Dermody TS. A monoclonal antibody specific for reovirus outer-capsid protein sigma3 inhibits sigma1-mediated hemagglutination by steric hindrance. J. Virol. 2001 Jul; 75(14): 6625-34. PMID: 11413330, PMCID: PMC114386, DOI: 10.1128/JVI.75.14.6625-6634.2001, ISSN: 0022-538X.

Mochow-Grundy M, Dermody TS. The reovirus S4 gene 3' nontranslated region contains a translational operator sequence. J. Virol. 2001 Jul; 75(14): 6517-26. PMID: 11413319, PMCID: PMC114375, DOI: 10.1128/JVI.75.14.6517-6526.2001, ISSN: 0022-538X.

Chandran K, Zhang X, Olson NH, Walker SB, Chappell JD, Dermody TS, Baker TS, Nibert ML. Complete in vitro assembly of the reovirus outer capsid produces highly infectious particles suitable for genetic studies of the receptor-binding protein. J. Virol. 2001 Jun; 75(11): 5335-42. PMID: 11333914, PMCID: PMC114938, DOI: 10.1128/JVI.75.11.5335-5342.2001, ISSN: 0022-538X.

Connolly JL, Barton ES, Dermody TS. Reovirus binding to cell surface sialic acid potentiates virus-induced apoptosis. J. Virol. 2001 May; 75(9): 4029-39. PMID: 11287552, PMCID: PMC114148, DOI: 10.1128/JVI.75.9.4029-4039.2001, ISSN: 0022-538X.

Ebert DH, Wetzel JD, Brumbaugh DE, Chance SR, Stobie LE, Baer GS, Dermody TS. Adaptation of reovirus to growth in the presence of protease inhibitor E64 segregates with a mutation in the carboxy terminus of viral outer-capsid protein sigma3. J. Virol. 2001 Apr; 75(7): 3197-206. PMID: 11238846, PMCID: PMC114113, DOI: 10.1128/JVI.75.7.3197-3206.2001, ISSN: 0022-538X.

Barton ES, Forrest JC, Connolly JL, Chappell JD, Liu Y, Schnell FJ, Nusrat A, Parkos CA, Dermody TS. Junction adhesion molecule is a receptor for reovirus. Cell. 2001 Feb 2/9/2001; 104(3): 441-51. PMID: 11239401, PII: S0092-8674(01)00231-8, ISSN: 0092-8674.

Becker MM, Goral MI, Hazelton PR, Baer GS, Rodgers SE, Brown EG, Coombs KM, Dermody TS. Reovirus sigmaNS protein is required for nucleation of viral assembly complexes and formation of viral inclusions. J. Virol. 2001 Feb; 75(3): 1459-75. PMID: 11152519, PMCID: PMC114052, DOI: 10.1128/JVI.75.3.1459-1475.2001, ISSN: 0022-538X.

Barton ES, Connolly JL, Forrest JC, Chappell JD, Dermody TS. Utilization of sialic acid as a coreceptor enhances reovirus attachment by multistep adhesion strengthening. J. Biol. Chem [print-electronic]. 2001 Jan 1/19/2001; 276(3): 2200-11. PMID: 11054410, PII: M004680200, DOI: 10.1074/jbc.M004680200, ISSN: 0021-9258.

Valyi-Nagy T, Olson SJ, Valyi-Nagy K, Montine TJ, Dermody TS. Herpes simplex virus type 1 latency in the murine nervous system is associated with oxidative damage to neurons. Virology. 2000 Dec 12/20/2000; 278(2): 309-21. PMID: 11118355, PII: S0042-6822(00)90678-0, DOI: 10.1006/viro.2000.0678, ISSN: 0042-6822.

Poggioli GJ, Keefer C, Connolly JL, Dermody TS, Tyler KL. Reovirus-induced G(2)/M cell cycle arrest requires sigma1s and occurs in the absence of apoptosis. J. Virol. 2000 Oct; 74(20): 9562-70. PMID: 11000227, PMCID: PMC112387, ISSN: 0022-538X.

Mohan KV, Dermody TS, Atreya CD. Mutations selected in rotavirus enterotoxin NSP4 depend on the context of its expression. Virology. 2000 Sep 9/15/2000; 275(1): 125-32. PMID: 11017794, PII: S0042682200904847, DOI: 10.1006/viro.2000.0484, ISSN: 0042-6822.

Chappell JD, Duong JL, Wright BW, Dermody TS. Identification of carbohydrate-binding domains in the attachment proteins of type 1 and type 3 reoviruses. J. Virol. 2000 Sep; 74(18): 8472-9. PMID: 10954547, PMCID: PMC116358, ISSN: 0022-538X.

Suara RO, Dermody TS. Enterococcal meningitis in an infant complicating congenital cutis aplasia. Pediatr. Infect. Dis. J. 2000 Jul; 19(7): 668-9. PMID: 10917233, ISSN: 0891-3668.

Mbisa JL, Becker MM, Zou S, Dermody TS, Brown EG. Reovirus mu2 protein determines strain-specific differences in the rate of viral inclusion formation in L929 cells. Virology. 2000 Jun 6/20/2000; 272(1): 16-26. PMID: 10873745, PII: S0042-6822(00)90362-3, DOI: 10.1006/viro.2000.0362, ISSN: 0042-6822.

Connolly JL, Rodgers SE, Clarke P, Ballard DW, Kerr LD, Tyler KL, Dermody TS. Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB. J. Virol. 2000 Apr; 74(7): 2981-9. PMID: 10708412, PMCID: PMC111796, ISSN: 0022-538X.

Valyi-Nagy T, Sidell KR, Marnett LJ, Roberts LJ, Dermody TS, Morrow JD, Montine TJ. Divergence of brain prostaglandin H synthase activity and oxidative damage in mice with encephalitis. J. Neuropathol. Exp. Neurol. 1999 Dec; 58(12): 1269-75. PMID: 10604752, ISSN: 0022-3069.

Baer GS, Ebert DH, Chung CJ, Erickson AH, Dermody TS. Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly. J. Virol. 1999 Nov; 73(11): 9532-43. PMID: 10516062, PMCID: PMC112988, ISSN: 0022-538X.

Winterbotham A, Riley S, Kavanaugh-McHugh A, Dermody TS. Endocarditis caused by group A beta-hemolytic Streptococcus in an infant: case report and review. Clin. Infect. Dis. 1999 Jul; 29(1): 196-8. PMID: 10433586, DOI: 10.1086/520153, ISSN: 1058-4838.

Debiasi RL, Squier MK, Pike B, Wynes M, Dermody TS, Cohen JJ, Tyler KL. Reovirus-induced apoptosis is preceded by increased cellular calpain activity and is blocked by calpain inhibitors. J. Virol. 1999 Jan; 73(1): 695-701. PMID: 9847375, PMCID: PMC103876, ISSN: 0022-538X.

Rodgers SE, Connolly JL, Chappell JD, Dermody TS. Reovirus growth in cell culture does not require the full complement of viral proteins: identification of a sigma1s-null mutant. J. Virol. 1998 Nov; 72(11): 8597-604. PMID: 9765398, PMCID: PMC110270, ISSN: 0022-538X.

Boyce TG, Craig AS, Schaffner W, Dermody TS. Fever and encephalopathy in two school age boys. Pediatr. Infect. Dis. J. 1998 Oct; 17(10): 935, 939-40. PMID: 9802647, ISSN: 0891-3668.

Chappell JD, Barton ES, Smith TH, Baer GS, Duong DT, Nibert ML, Dermody TS. Cleavage susceptibility of reovirus attachment protein sigma1 during proteolytic disassembly of virions is determined by a sequence polymorphism in the sigma1 neck. J. Virol. 1998 Oct; 72(10): 8205-13. PMID: 9733863, PMCID: PMC110170, ISSN: 0022-538X.

Mrukowicz JZ, Wetzel JD, Goral MI, Fogo AB, Wright PF, Dermody TS. Viruses and cells with mutations affecting viral entry are selected during persistent rotavirus infections of MA104 cells. J. Virol. 1998 Apr; 72(4): 3088-97. PMID: 9525634, PMCID: PMC109759, ISSN: 0022-538X.

Virgin HW, Dermody TS, Tyler KL. Cellular and humoral immunity to reovirus infection. Curr. Top. Microbiol. Immunol. 1998; 233(Pt 2): 147-61. PMID: 9599936, ISSN: 0070-217X.

Oberhaus SM, Dermody TS, Tyler KL. Apoptosis and the cytopathic effects of reovirus. Curr. Top. Microbiol. Immunol. 1998; 233(Pt 2): 23-49. PMID: 9599930, ISSN: 0070-217X.

Dermody TS. Molecular mechanisms of persistent infection by reovirus. Curr. Top. Microbiol. Immunol. 1998; 233(Pt 2): 1-22. PMID: 9599929, ISSN: 0070-217X.

Baer GS, Dermody TS. Mutations in reovirus outer-capsid protein sigma3 selected during persistent infections of L cells confer resistance to protease inhibitor E64. J. Virol. 1997 Jul; 71(7): 4921-8. PMID: 9188554, PMCID: PMC191722, ISSN: 0022-538X.

Rodgers SE, Barton ES, Oberhaus SM, Pike B, Gibson CA, Tyler KL, Dermody TS. Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2. J. Virol. 1997 Mar; 71(3): 2540-6. PMID: 9032397, PMCID: PMC191370, ISSN: 0022-538X.

Oberhaus SM, Smith RL, Clayton GH, Dermody TS, Tyler KL. Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis. J. Virol. 1997 Mar; 71(3): 2100-6. PMID: 9032342, PMCID: PMC191302, ISSN: 0022-538X.

Chappell JD, Gunn VL, Wetzel JD, Baer GS, Dermody TS. Mutations in type 3 reovirus that determine binding to sialic acid are contained in the fibrous tail domain of viral attachment protein sigma1. J. Virol. 1997 Mar; 71(3): 1834-41. PMID: 9032313, PMCID: PMC191253, ISSN: 0022-538X.

Snell JE, Addlestone GL, Dermody TS. An innovative AIDS elective [letter]. Acad Med. 1997 Feb; 72(2): 90-1. PMID: 9040239, ISSN: 1040-2446.

Wetzel JD, Wilson GJ, Baer GS, Dunnigan LR, Wright JP, Tang DS, Dermody TS. Reovirus variants selected during persistent infections of L cells contain mutations in the viral S1 and S4 genes and are altered in viral disassembly. J. Virol. 1997 Feb; 71(2): 1362-9. PMID: 8995660, PMCID: PMC191191, ISSN: 0022-538X.

Wetzel JD, Chappell JD, Fogo AB, Dermody TS. Efficiency of viral entry determines the capacity of murine erythroleukemia cells to support persistent infections by mammalian reoviruses. J. Virol. 1997 Jan; 71(1): 299-306. PMID: 8985350, PMCID: PMC191051, ISSN: 0022-538X.

Tyler KL, Squier MK, Brown AL, Pike B, Willis D, Oberhaus SM, Dermody TS, Cohen JJ. Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: role of the S1 and M2 genes. J. Virol. 1996 Nov; 70(11): 7984-91. PMID: 8892922, PMCID: PMC190871, ISSN: 0022-538X.

Wilson GJ, Wetzel JD, Puryear W, Bassel-Duby R, Dermody TS. Persistent reovirus infections of L cells select mutations in viral attachment protein sigma1 that alter oligomer stability. J. Virol. 1996 Oct; 70(10): 6598-606. PMID: 8794294, PMCID: PMC190700, ISSN: 0022-538X.

Goral MI, Mochow-Grundy M, Dermody TS. Sequence diversity within the reovirus S3 gene: reoviruses evolve independently of host species, geographic locale, and date of isolation. Virology. 1996 Feb 2/1/1996; 216(1): 265-71. PMID: 8615001, PII: S0042-6822(96)90059-8, DOI: 10.1006/viro.1996.0059, ISSN: 0042-6822.

Tyler KL, Squier MK, Rodgers SE, Schneider BE, Oberhaus SM, Grdina TA, Cohen JJ, Dermody TS. Differences in the capacity of reovirus strains to induce apoptosis are determined by the viral attachment protein sigma 1. J. Virol. 1995 Nov; 69(11): 6972-9. PMID: 7474116, PMCID: PMC189616, ISSN: 0022-538X.

Dermody TS, Chappell JD, Hofler JG, Kramp W, Tyler KL. Eradication of persistent reovirus infection from a B-cell hybridoma. Virology. 1995 Sep 9/10/1995; 212(1): 272-6. PMID: 7676645, PII: S0042-6822(85)71483-3, DOI: 10.1006/viro.1995.1483, ISSN: 0042-6822.

Borowsky AD, Stein SM, Tulipan NB, Dermody TS. Meningitis caused by mixed anaerobic species complicating tethered cord syndrome. Clin. Infect. Dis. 1995 Sep; 21(3): 706-7. PMID: 8527587, ISSN: 1058-4838.

Nibert ML, Chappell JD, Dermody TS. Infectious subvirion particles of reovirus type 3 Dearing exhibit a loss in infectivity and contain a cleaved sigma 1 protein. J. Virol. 1995 Aug; 69(8): 5057-67. PMID: 7609075, PMCID: PMC189323, ISSN: 0022-538X.

Haller BL, Barkon ML, Li XY, Hu WM, Wetzel JD, Dermody TS, Virgin HW. Brain- and intestine-specific variants of reovirus serotype 3 strain dearing are selected during chronic infection of severe combined immunodeficient mice. J. Virol. 1995 Jun; 69(6): 3933-7. PMID: 7745749, PMCID: PMC189121, ISSN: 0022-538X.

Wilson GJ, Talkington DF, Gruber W, Edwards K, Dermody TS. Group A streptococcal necrotizing fasciitis following varicella in children: case reports and review. Clin. Infect. Dis. 1995 May; 20(5): 1333-8. PMID: 7620020, ISSN: 1058-4838.

Chapell JD, Goral MI, Rodgers SE, dePamphilis CW, Dermody TS. Sequence diversity within the reovirus S2 gene: reovirus genes reassort in nature, and their termini are predicted to form a panhandle motif. J. Virol. 1994 Feb; 68(2): 750-6. PMID: 8289378, PMCID: PMC236511, ISSN: 0022-538X.

Morrison LA, Fields BN, Dermody TS. Prolonged replication in the mouse central nervous system of reoviruses isolated from persistently infected cell cultures. J. Virol. 1993 Jun; 67(6): 3019-26. PMID: 8388486, PMCID: PMC237638, ISSN: 0022-538X.

Dermody TS, Nibert ML, Wetzel JD, Tong X, Fields BN. Cells and viruses with mutations affecting viral entry are selected during persistent infections of L cells with mammalian reoviruses. J. Virol. 1993 Apr; 67(4): 2055-63. PMID: 8383227, PMCID: PMC240279, ISSN: 0022-538X.

Rubin DH, Wetzel JD, Williams WV, Cohen JA, Dworkin C, Dermody TS. Binding of type 3 reovirus by a domain of the sigma 1 protein important for hemagglutination leads to infection of murine erythroleukemia cells. J. Clin. Invest. 1992 Dec; 90(6): 2536-42. PMID: 1281838, PMCID: PMC443412, DOI: 10.1172/JCI116147, ISSN: 0021-9738.

Hirschhorn LR, McIntosh K, Anderson KG, Dermody TS. Influenzal pneumonia as a complication of autologous bone marrow transplantation. Clin. Infect. Dis. 1992 Mar; 14(3): 786-7. PMID: 1562672, ISSN: 1058-4838.

Dermody TS, Schiff LA, Nibert ML, Coombs KM, Fields BN. The S2 gene nucleotide sequences of prototype strains of the three reovirus serotypes: characterization of reovirus core protein sigma 2. J. Virol. 1991 Nov; 65(11): 5721-31. PMID: 1920614, PMCID: PMC250232, ISSN: 0022-538X.

Dever LA, Dermody TS. Mechanisms of bacterial resistance to antibiotics. Arch. Intern. Med. 1991 May; 151(5): 886-95. PMID: 2025137, ISSN: 0003-9926.

Dermody TS, Nibert ML, Bassel-Duby R, Fields BN. A sigma 1 region important for hemagglutination by serotype 3 reovirus strains. J. Virol. 1990 Oct; 64(10): 5173-6. PMID: 2398540, PMCID: PMC248012, ISSN: 0022-538X.

Dermody TS, Nibert ML, Bassel-Duby R, Fields BN. Sequence diversity in S1 genes and S1 translation products of 11 serotype 3 reovirus strains. J. Virol. 1990 Oct; 64(10): 4842-50. PMID: 2398530, PMCID: PMC247973, ISSN: 0022-538X.

Nibert ML, Dermody TS, Fields BN. Structure of the reovirus cell-attachment protein: a model for the domain organization of sigma 1. J. Virol. 1990 Jun; 64(6): 2976-89. PMID: 2335823, PMCID: PMC249482, ISSN: 0022-538X.