Edwin F. Donnelly, M.D., Ph.D.

Associate Professor

edwin.donnelly@vanderbilt.edu
Faculty Appointments
Associate Professor of Radiology and Radiological Sciences Associate Professor of Biomedical Engineering
Education
Ph.D., Biomedical Engineering, Vanderbilt University, Nashville, TennesseeM.D., Medicine, University of Cincinnati, Cincinnati, OhioB.S., Biochemistry, University of Cincinnati, Cincinnati, Ohio
Office Address
1161 21st Avenue South
MCN CC 1121
Nashville, TN 37232-2675
Research Keywords
Phase - Contrast Radiology Power Doppler Ultrasound Anti-angiogenesis treatments for cancer Small animal imaging Computed Tomography
Clinical Research Keywords
Thoracic Radiology
Publications
Lockhart AC, Cropp GF, Berlin JD, Donnelly E, Schumaker RD, Schaaf LJ, Hande KR, Fleischer AC, Hannah AL, Rothenberg ML. Phase I/pilot study of SU5416 (semaxinib) in combination with irinotecan/bolus 5-FU/LV (IFL) in patients with metastatic colorectal cancer. Am. J. Clin. Oncol. 2006 Apr; 29(2): 109-15. PMID: 16601426, PII: 00000421-200604000-00001, DOI: 10.1097/01.coc.0000199882.53545.ac, ISSN: 1537-453X.

Donnelly EF, Lewis KG, Wolske KM, Pickens DR, Price RR. Characterization of the phase-contrast radiography edge-enhancement effect in a cabinet x-ray system. Phys Med Biol [print-electronic]. 2006 Jan 1/7/2006; 51(1): 21-30. PMID: 16357428, PII: S0031-9155(06)07960-7, DOI: 10.1088/0031-9155/51/1/002, ISSN: 0031-9155.

Lawson WE, Polosukhin VV, Stathopoulos GT, Zoia O, Han W, Lane KB, Li B, Donnelly EF, Holburn GE, Lewis KG, Collins RD, Hull WM, Glasser SW, Whitsett JA, Blackwell TS. Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin. Am. J. Pathol. 2005 Nov; 167(5): 1267-77. PMID: 16251411, PMCID: PMC1603790, PII: S0002-9440(10)61214-X, DOI: 10.1016/S0002-9440(10)61214-X, ISSN: 0002-9440.

Cao C, Shinohara ET, Niermann KJ, Donnelly EF, Chen X, Hallahan DE, Lu B. Murine double minute 2 as a therapeutic target for radiation sensitization of lung cancer. Mol. Cancer Ther. 2005 Aug; 4(8): 1137-45. PMID: 16093429, PII: 4/8/1137, DOI: 10.1158/1535-7163.MCT-04-0327, ISSN: 1535-7163.

Zhu Z, Donnelly E, Dikensoy O, Misra H, Bilaceroglu S, Lane KB, Light RW. Efficacy of ultrasound in the diagnosis of pleurodesis in rabbits. Chest. 2005 Aug; 128(2): 934-9. PMID: 16100189, PII: 128/2/934, DOI: 10.1378/chest.128.2.934, ISSN: 0012-3692.

Niermann KJ, Fleischer AC, Donnelly EF, Schueneman AJ, Geng L, Hallahan DE. Sonographic depiction of changes of tumor vascularity in response to various therapies. Ultrasound Q. 2005 Jun; 21(2): 61-7; quiz 149, 153. PMID: 15905816, PII: 00013644-200506000-00002, ISSN: 0894-8771.

Chen Y, Donnelly E, Kobayashi H, Debusk LM, Lin PC. Gene therapy targeting the Tie2 function ameliorates collagen-induced arthritis and protects against bone destruction. Arthritis Rheum. 2005 May; 52(5): 1585-94. PMID: 15880817, DOI: 10.1002/art.21016, ISSN: 0004-3591.

Donnelly EF, Price RR, Pickens DR. Experimental validation of the Wigner distributions theory of phase-contrast imaging. Med Phys. 2005 Apr; 32(4): 928-31. PMID: 15895575, ISSN: 0094-2405.

Fleischer AC, Niermann KJ, Donnelly EF, Yankeelov TE, Canniff KM, Hallahan DE, Rothenberg ME. Sonographic depiction of microvessel perfusion: principles and potential. J Ultrasound Med. 2004 Nov; 23(11): 1499-506. PMID: 15498915, PII: 23/11/1499, ISSN: 0278-4297.

Lu B, Geng L, Musiek A, Tan J, Cao C, Donnelly E, McMahon G, Choy H, Hallahan DE. Broad spectrum receptor tyrosine kinase inhibitor, SU6668, sensitizes radiation via targeting survival pathway of vascular endothelium. Int. J. Radiat. Oncol. Biol. Phys. 2004 Mar 3/1/2004; 58(3): 844-50. PMID: 14967441, PII: S0360301603022843, DOI: 10.1016/j.ijrobp.2003.10.049, ISSN: 0360-3016.

Fleischer AC, Donnelly EF, Grippo RJ, Black AS, Hallahan DE. Quantification of tumor vascularity with contrast-enhanced sonography: correlation with magnetic resonance imaging and fluorodeoxyglucose autoradiography in an implanted tumor. J Ultrasound Med. 2004 Jan; 23(1): 37-41. PMID: 14756351, ISSN: 0278-4297.

Donnelly EF, Price RR, Pickens DR. Quantification of the effect of system and object parameters on edge enhancement in phase-contrast radiography. Med Phys. 2003 Nov; 30(11): 2888-96. PMID: 14655935, ISSN: 0094-2405.

Donnelly EF, Price RR, Pickens DR. Dual focal-spot imaging for phase extraction in phase-contrast radiography. Med Phys. 2003 Sep; 30(9): 2292-6. PMID: 14528949, ISSN: 0094-2405.

Schueneman AJ, Himmelfarb E, Geng L, Tan J, Donnelly E, Mendel D, McMahon G, Hallahan DE. SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res. 2003 Jul 7/15/2003; 63(14): 4009-16. PMID: 12873999, ISSN: 0008-5472.

Hallahan D, Geng L, Qu S, Scarfone C, Giorgio T, Donnelly E, Gao X, Clanton J. Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels. Cancer Cell. 2003 Jan; 3(1): 63-74. PMID: 12559176, PII: S1535610802002386, ISSN: 1535-6108.

D'Haese, PF, Duay V, Li R, du Bois d'Aische, A, Merchant, TE, Cmelak, AJ, Donnelly, EF, Niermann, KJ, Macq, B, Dawant, BM. Automatic segmentation of brain structures for radiation therapy planning. in Proceedings of SPIE: Medical Imaging 2003: Image Processing. Ed by: Milan Sonka, J. Michael Fitzpatrick. 2003; 5032: 517-26.

Edwards E, Geng L, Tan J, Onishko H, Donnelly E, Hallahan DE. Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation. Cancer Res. 2002 Aug 8/15/2002; 62(16): 4671-7. PMID: 12183424, ISSN: 0008-5472.

Donnelly EF, Price RR. Quantification of the effect of kvp on edge-enhancement index in phase-contrast radiography. Med Phys. 2002 Jun; 29(6): 999-1002. PMID: 12094995, ISSN: 0094-2405.

Muniz CJ, Fleischer AC, Donnelly EF, Mazer MJ. Three-dimensional color Doppler sonography and uterine artery arteriography of fibroids: assessment of changes in vascularity before and after embolization. J Ultrasound Med. 2002 Feb; 21(2): 129-33. PMID: 11833868, ISSN: 0278-4297.

Donnelly EF, Geng L, Wojcicki WE, Fleischer AC, Hallahan DE. Quantified power Doppler US of tumor blood flow correlates with microscopic quantification of tumor blood vessels. Radiology. 2001 Apr; 219(1): 166-70. PMID: 11274552, DOI: 10.1148/radiology.219.1.r01ap38166, ISSN: 0033-8419.

Geng L, Donnelly E, McMahon G, Lin PC, Sierra-Rivera E, Oshinka H, Hallahan DE. Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. Cancer Res. 2001 Mar 3/15/2001; 61(6): 2413-9. PMID: 11289107, ISSN: 0008-5472.

Fleischer AC, Donnelly EF, Campbell MG, Mazer MJ, Grippo D, Lipsitz NL. Three-dimensional color Doppler sonography before and after fibroid embolization. J Ultrasound Med. 2000 Oct; 19(10): 701-5. PMID: 11026583, ISSN: 0278-4297.

Fleischer AC, Wojcicki WE, Donnelly EF, Pickens DR, Thirsk G, Thurman GB, Hellerqvist CG. Quantified color Doppler sonography of tumor vascularity in an animal model. J Ultrasound Med. 1999 Aug; 18(8): 547-51. PMID: 10447080, ISSN: 0278-4297.

Donnelly EF. The Hawkins sign. Radiology. 1999 Jan; 210(1): 195-6. PMID: 9885607, DOI: 10.1148/radiology.210.1.r99ja08195, ISSN: 0033-8419.