Mary E. Courtney Moore, Ph.D.

Research Professor

genie.moore@vanderbilt.edu
Faculty Appointments
Research Professor of Molecular Physiology and Biophysics
Education
Ph.D., Mol Physiol/Biophys, Vanderbilt University, Nashville, TennesseeM.S.N., Nursing, University of Texas, San Antonio, TexasB.S., Nursing, Baylor University, Waco, Texas
Office Address
710 Light Hall
Nashville, TN 0615
Publications
Nishizawa M, Shiota M, Moore MC, Gustavson SM, Neal DW, Cherrington AD. Intraportal administration of neuropeptide Y and hepatic glucose metabolism. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2008 Apr; 294(4): R1197-204. PMID: 18234742, PII: 00903.2007, DOI: 10.1152/ajpregu.00903.2007, ISSN: 0363-6119.

Moore MC, Dicostanzo CA, Smith MS, Farmer B, Rodewald TD, Neal DW, Williams PE, Cherrington AD. Hepatic portal venous delivery of a nitric oxide synthase inhibitor enhances net hepatic glucose uptake. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2008 Apr; 294(4): E768-77. PMID: 18212022, PII: 00184.2007, DOI: 10.1152/ajpendo.00184.2007, ISSN: 0193-1849.

An Z, DiCostanzo CA, Moore MC, Edgerton DS, Dardevet DP, Neal DW, Cherrington AD. Effects of the nitric oxide donor SIN-1 on net hepatic glucose uptake in the conscious dog. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2008 Feb; 294(2): E300-6. PMID: 18029444, PII: 00380.2007, DOI: 10.1152/ajpendo.00380.2007, ISSN: 0193-1849.

Cherrington AD, Moore MC, Sindelar DK, Edgerton DS. Insulin action on the liver in vivo. Biochem. Soc. Trans. 2007 Nov; 35(Pt 5): 1171-4. PMID: 17956305, PII: BST0351171, DOI: 10.1042/BST0351171, ISSN: 0300-5127.

Connolly CC, Papa T, Smith MS, Lacy DB, Williams PE, Moore MC. Hepatic and muscle insulin action during late pregnancy in the dog. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2007 Jan; 292(1): R447-52. PMID: 16973936, PMCID: PMC2430046, PII: 00385.2006, DOI: 10.1152/ajpregu.00385.2006, ISSN: 0363-6119.

Moore MC. Drug evaluation: tagatose in the treatment of type 2 diabetes and obesity. Curr Opin Investig Drugs. 2006 Oct; 7(10): 924-35. PMID: 17086938, ISSN: 1472-4472.

Canniff KM, Smith MS, Lacy DB, Williams PE, Moore MC. Glucagon secretion and autonomic signaling during hypoglycemia in late pregnancy. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2006 Sep; 291(3): R788-95. PMID: 16556905, PMCID: PMC2430050, PII: 00125.2006, DOI: 10.1152/ajpregu.00125.2006, ISSN: 0363-6119.

Dardevet, D, Moore, MC, Remond, D, Everett-Grueter, CA, Cherrington, AD. Regulation of hepatic metabolism by enteral delivery of nutrients [editorial]. Nutrition Research Reviews. 2006; 19((02)): 161-73.

Dardevet D, Moore MC, DiCostanzo CA, Farmer B, Neal DW, Snead W, Lautz M, Cherrington AD. Insulin secretion-independent effects of GLP-1 on canine liver glucose metabolism do not involve portal vein GLP-1 receptors. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2005 Nov; 289(5): G806-14. PMID: 16051922, PMCID: PMC2435373, PII: 00121.2005, DOI: 10.1152/ajpgi.00121.2005, ISSN: 0193-1857.

Batista MR, Smith MS, Snead WL, Connolly CC, Lacy DB, Moore MC. Chronic estradiol and progesterone treatment in conscious dogs: effects on insulin sensitivity and response to hypoglycemia. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2005 Oct; 289(4): R1064-73. PMID: 15961530, PMCID: PMC2442479, PII: 00311.2005, DOI: 10.1152/ajpregu.00311.2005, ISSN: 0363-6119.

Grubert JM, Lautz M, Lacy DB, Moore MC, Farmer B, Penaloza A, Cherrington AD, McGuinness OP. Impact of continuous and pulsatile insulin delivery on net hepatic glucose uptake. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2005 Aug; 289(2): E232-40. PMID: 15755768, PII: 00567.2004, DOI: 10.1152/ajpendo.00567.2004, ISSN: 0193-1849.

Moore MC, Kimura K, Shibata H, Honjoh T, Saito M, Everett CA, Smith MS, Cherrington AD. Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2005 Aug; 289(2): E225-31. PMID: 15755767, PMCID: PMC2430063, PII: 00614.2004, DOI: 10.1152/ajpendo.00614.2004, ISSN: 0193-1849.

DiCostanzo CA, Moore MC, Lautz M, Scott M, Farmer B, Everett CA, Still JG, Higgins A, Cherrington AD. Simulated first-phase insulin release using Humulin or insulin analog HIM2 is associated with prolonged improvement in postprandial glycemia. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2005 Jul; 289(1): E46-52. PMID: 15713685, PII: 00583.2004, DOI: 10.1152/ajpendo.00583.2004, ISSN: 0193-1849.

Moore MC, DiCostanzo CA, Dardevet D, Lautz M, Farmer B, Cherrington AD. Interaction of a selective serotonin reuptake inhibitor with insulin in the control of hepatic glucose uptake in conscious dogs. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2005 Mar; 288(3): E556-63. PMID: 15522992, PII: 00405.2004, DOI: 10.1152/ajpendo.00405.2004, ISSN: 0193-1849.

Moore MC, DiCostanzo CA, Dardevet D, Lautz M, Farmer B, Neal DW, Cherrington AD. Portal infusion of a selective serotonin reuptake inhibitor enhances hepatic glucose disposal in conscious dogs. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Dec; 287(6): E1057-63. PMID: 15315909, PII: 00313.2004, DOI: 10.1152/ajpendo.00313.2004, ISSN: 0193-1849.

Cardin S, Pagliassotti MJ, Moore MC, Edgerton DS, Lautz M, Farmer B, Neal DW, Cherrington AD. Vagal cooling and concomitant portal norepinephrine infusion do not reduce net hepatic glucose uptake in conscious dogs. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2004 Oct; 287(4): R742-8. PMID: 15166005, PII: 00041.2004, DOI: 10.1152/ajpregu.00041.2004, ISSN: 0363-6119.

Connolly CC, Aglione LN, Smith MS, Lacy DB, Moore MC. Pregnancy impairs the counterregulatory response to insulin-induced hypoglycemia in the dog. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Sep; 287(3): E480-8. PMID: 15126242, PII: 00529.2003, DOI: 10.1152/ajpendo.00529.2003, ISSN: 0193-1849.

Dardevet D, Moore MC, Neal D, DiCostanzo CA, Snead W, Cherrington AD. Insulin-independent effects of GLP-1 on canine liver glucose metabolism: duration of infusion and involvement of hepatoportal region. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Jul; 287(1): E75-81. PMID: 15026303, PII: 00035.2004, DOI: 10.1152/ajpendo.00035.2004, ISSN: 0193-1849.

Connolly CC, Aglione LN, Smith MS, Lacy DB, Moore MC. Insulin action during late pregnancy in the conscious dog. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Jun; 286(6): E909-15. PMID: 14749203, PII: 00143.2003, DOI: 10.1152/ajpendo.00143.2003, ISSN: 0193-1849.

Moore MC, Cardin S, Edgerton DS, Farmer B, Neal DW, Lautz M, Cherrington AD. Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2004 Feb; 286(2): E226-33. PMID: 14519598, PII: 00343.2003, DOI: 10.1152/ajpendo.00343.2003, ISSN: 0193-1849.

Moore MC, Satake S, Lautz M, Soleimanpour SA, Neal DW, Smith M, Cherrington AD. Nonesterified fatty acids and hepatic glucose metabolism in the conscious dog. Diabetes. 2004 Jan; 53(1): 32-40. PMID: 14693695, ISSN: 0012-1797.

Moore MC, Geho WB, Lautz M, Farmer B, Neal DW, Cherrington AD. Portal serotonin infusion and glucose disposal in conscious dogs. Diabetes. 2004 Jan; 53(1): 14-20. PMID: 14693692, ISSN: 0012-1797.

Moore MC, Burish MJ, Farmer B, Neal DW, Pan C, Cherrington AD. Chronic hepatic artery ligation does not prevent liver from differentiating portal vs. peripheral glucose delivery. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2003 Oct; 285(4): E845-53. PMID: 12773306, PII: 00130.2003, DOI: 10.1152/ajpendo.00130.2003, ISSN: 0193-1849.

Moore MC, Cherrington AD, Wasserman DH. Regulation of hepatic and peripheral glucose disposal. Best Pract. Res. Clin. Endocrinol. Metab. 2003 Sep; 17(3): 343-64. PMID: 12962690, PII: S1521690X03000368, ISSN: 1521-690X.

Nishizawa M, Moore MC, Shiota M, Gustavson SM, Snead WL, Neal DW, Cherrington AD. Effect of intraportal glucagon-like peptide-1 on glucose metabolism in conscious dogs. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2003 May; 284(5): E1027-36. PMID: 12569088, PII: 00503.2002, DOI: 10.1152/ajpendo.00503.2002, ISSN: 0193-1849.

Cherrington AD, Connolly CC, Chu CA, Moore MC. The role of neural signalling and hypoglycaemia per se in the counterregulatory response. Diabetes Nutr. Metab. 2002 Oct; 15(5): 303-7; discussion 307. PMID: 12625474, ISSN: 0394-3402.

Dunning BE, Moore MC, Ikeda T, Neal DW, Scott MF, Cherrington AD. Portal glucose infusion exerts an incretin effect associated with changes in pancreatic neural activity in conscious dogs. Metab. Clin. Exp. 2002 Oct; 51(10): 1324-30. PMID: 12370854, PII: S0026049502000860, ISSN: 0026-0495.

Satake S, Moore MC, Igawa K, Converse M, Farmer B, Neal DW, Cherrington AD. Direct and indirect effects of insulin on glucose uptake and storage by the liver. Diabetes. 2002 Jun; 51(6): 1663-71. PMID: 12031951, ISSN: 0012-1797.

Shiota M, Moore MC, Galassetti P, Monohan M, Neal DW, Shulman GI, Cherrington AD. Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog. Diabetes. 2002 Feb; 51(2): 469-78. PMID: 11812757, ISSN: 0012-1797.

Moore MC, Satake S, Baranowski B, Hsieh PS, Neal DW, Cherrington AD. Effect of hepatic denervation on peripheral insulin sensitivity in conscious dogs. Am. J. Physiol. Endocrinol. Metab. 2002 Feb; 282(2): E286-96. PMID: 11788359, DOI: 10.1152/ajpendo.00201.2001, ISSN: 0193-1849.

Moore MC, Cherrington AD, Palmer B, Lacy DB, Goldstein RE. Effects of cyclosporine A and prednisone treatment on mixed meal disposition in dogs with hepatic denervation. JPEN J Parenter Enteral Nutr. 2002 Jan; 26(1): 42-50. PMID: 11833750, ISSN: 0148-6071.

Moore MC, Davis SN, Mann SL, Cherrington AD. Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes. Diabetes Care. 2001 Nov; 24(11): 1882-7. PMID: 11679451, ISSN: 0149-5992.

Moore MC, Cherrington AD, Mann SL, Davis SN. Acute fructose administration decreases the glycemic response to an oral glucose tolerance test in normal adults. J. Clin. Endocrinol. Metab. 2000 Dec; 85(12): 4515-9. PMID: 11134101, DOI: 10.1210/jcem.85.12.7053, ISSN: 0021-972X.

Moore MC, Hsieh PS, Neal DW, Cherrington AD. Nonhepatic response to portal glucose delivery in conscious dogs. Am. J. Physiol. Endocrinol. Metab. 2000 Dec; 279(6): E1271-7. PMID: 11093914, ISSN: 0193-1849.

Hsieh PS, Moore MC, Neal DW, Cherrington AD. Importance of the hepatic arterial glucose level in generation of the portal signal in conscious dogs. Am. J. Physiol. Endocrinol. Metab. 2000 Aug; 279(2): E284-92. PMID: 10913027, ISSN: 0193-1849.

Moore MC, Cherrington AD, Palmer B, Lacy DB, Goldstein RE. Disposition of a mixed meal by conscious dogs after seven days of treatment with cyclosporine A and prednisone. JPEN J Parenter Enteral Nutr. 2000 Jul; 24(4): 244-50. PMID: 10885720, ISSN: 0148-6071.

Moore MC, Hsieh PS, Flakoll PJ, Neal DW, Cherrington AD. Net hepatic gluconeogenic amino acid uptake in response to peripheral versus portal amino acid infusion in conscious dogs. J. Nutr. 1999 Dec; 129(12): 2218-24. PMID: 10573553, ISSN: 0022-3166.

Hsieh PS, Moore MC, Marshall B, Pagliassotti MJ, Shay B, Szurkus D, Neal DW, Cherrington AD. The head arterial glucose level is not the reference site for generation of the portal signal in conscious dogs. Am. J. Physiol. 1999 Oct; 277(4 Pt 1): E678-84. PMID: 10516127, ISSN: 0002-9513.

Moore MC, Lin DW, Colburn CA, Goldstein RE, Neal DW, Cherrington AD. Insulin- and glucagon-independent effects of calcitonin gene-related peptide in the conscious dog. Metab. Clin. Exp. 1999 May; 48(5): 603-10. PMID: 10337861, PII: S0026-0495(99)90058-6, ISSN: 0026-0495.

Hsieh PS, Moore MC, Neal DW, Emshwiller M, Cherrington AD. Rapid reversal of the effects of the portal signal under hyperinsulinemic conditions in the conscious dog. Am. J. Physiol. 1999 May; 276(5 Pt 1): E930-7. PMID: 10329988, ISSN: 0002-9513.

Moore MC, Hsieh PS, Flakoll PJ, Neal DW, Cherrington AD. Differential effect of amino acid infusion route on net hepatic glucose uptake in the dog. Am. J. Physiol. 1999 Feb; 276(2 Pt 1): E295-302. PMID: 9950789, ISSN: 0002-9513.

Hsieh PS, Moore MC, Neal DW, Cherrington AD. Hepatic glucose uptake rapidly decreases after removal of the portal signal in conscious dogs. Am. J. Physiol. 1998 Dec; 275(6 Pt 1): E987-92. PMID: 9843741, ISSN: 0002-9513.

Moore MC, Flakoll PJ, Hsieh PS, Pagliassotti MJ, Neal DW, Monohan MT, Venable C, Cherrington AD. Hepatic glucose disposition during concomitant portal glucose and amino acid infusions in the dog. Am. J. Physiol. 1998 May; 274(5 Pt 1): E893-902. PMID: 9612248, ISSN: 0002-9513.

Moore MC, Connolly CC, Cherrington AD. Autoregulation of hepatic glucose production. Eur. J. Endocrinol. 1998 Mar; 138(3): 240-8. PMID: 9539293, ISSN: 0804-4643.

Holste LC, Connolly CC, Moore MC, Neal DW, Cherrington AD. Physiological changes in circulating glucagon alter hepatic glucose disposition during portal glucose delivery. Am. J. Physiol. 1997 Sep; 273(3 Pt 1): E488-96. PMID: 9316437, ISSN: 0002-9513.

Moore MC, Rossetti L, Pagliassotti MJ, Monahan M, Venable C, Neal D, Cherrington AD. Neural and pancreatic influences on net hepatic glucose uptake and glycogen synthesis. Am. J. Physiol. 1996 Aug; 271(2 Pt 1): E215-22. PMID: 8770013, ISSN: 0002-9513.

Moore MC, Cherrington AD. Regulation of net hepatic glucose uptake: interaction of neural and pancreatic mechanisms. Reprod. Nutr. Dev. 1996; 36(4): 399-406. PMID: 8878357, PII: 0926528796819794, ISSN: 0926-5287.

Pagliassotti MJ, Holste LC, Moore MC, Neal DW, Cherrington AD. Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J. Clin. Invest. 1996 Jan 1/1/1996; 97(1): 81-91. PMID: 8550854, PMCID: PMC507065, DOI: 10.1172/JCI118410, ISSN: 0021-9738.

Moore MC, Pagliassotti MJ, Goldstein RE, Asher J, Murrell J, Neal D, Cherrington AD. The effect of the hepatic nerves on the disposition of a mixed meal by conscious dogs. JPEN J Parenter Enteral Nutr. 1994 May; 18(3): 248-55. PMID: 8065001, ISSN: 0148-6071.

Moore MC, Pagliassotti MJ, Swift LL, Asher J, Murrell J, Neal D, Cherrington AD. Disposition of a mixed meal by the conscious dog. Am. J. Physiol. 1994 Apr; 266(4 Pt 1): E666-75. PMID: 8178989, ISSN: 0002-9513.

Moore MC, Pagliassotti MJ, Wasserman DH, Goldstein R, Asher J, Neal DW, Cherrington AD. Hepatic denervation alters the transition from the fed to the food-deprived state in conscious dogs. J. Nutr. 1993 Oct; 123(10): 1739-46. PMID: 8410366, ISSN: 0022-3166.

Moore MC, Shulman GI, Giaccari A, Pagliassotti MJ, Cline G, Neal D, Rossetti L, Cherrington AD. Effect of hepatic nerves on disposition of an intraduodenal glucose load. Am. J. Physiol. 1993 Sep; 265(3 Pt 1): E487-96. PMID: 8214056, ISSN: 0002-9513.

Pagliassotti MJ, Colburn CA, Moore MC, Neal DW, Dominianni SJ, Stephens TW, Cherrington AD. Regulation of net hepatic substrate balance by phenacylimidazolium ions in the conscious dog. Diabetes Res. 1993; 22(3): 123-33. PMID: 7915646, ISSN: 0265-5985.

Pagliassotti MJ, Moore MC, Neal DW, Cherrington AD. Insulin is required for the liver to respond to intraportal glucose delivery in the conscious dog. Diabetes. 1992 Oct; 41(10): 1247-56. PMID: 1397697, ISSN: 0012-1797.

Pagliassotti MJ, Myers SR, Moore MC, Neal DW, Cherrington AD. Magnitude of negative arterial-portal glucose gradient alters net hepatic glucose balance in conscious dogs. Diabetes. 1991 Dec; 40(12): 1659-68. PMID: 1684554, ISSN: 0012-1797.

Moore MC, Cherrington AD, Cline G, Pagliassotti MJ, Jones EM, Neal DW, Badet C, Shulman GI. Sources of carbon for hepatic glycogen synthesis in the conscious dog. J. Clin. Invest. 1991 Aug; 88(2): 578-87. PMID: 1864968, PMCID: PMC295390, DOI: 10.1172/JCI115342, ISSN: 0021-9738.

Greene HL, Phillips BL, Franck L, Fillmore CM, Said HM, Murrell JE, Moore ME, Briggs R. Persistently low blood retinol levels during and after parenteral feeding of very low birth weight infants: examination of losses into intravenous administration sets and a method of prevention by addition to a lipid emulsion. Pediatrics. 1987 Jun; 79(6): 894-900. PMID: 3108847, ISSN: 0031-4005.

Greene HL, Moore ME, Phillips B, Franck L, Shulman RJ, Ament ME, Murrell JE, Chan MM, Said HM. Evaluation of a pediatric multiple vitamin preparation for total parenteral nutrition. II. Blood levels of vitamins A, D, and E. Pediatrics. 1986 Apr; 77(4): 539-47. PMID: 3083397, ISSN: 0031-4005.

Moore ME, Moran JR, Greene HL. Zinc supplementation in lactating women: evidence for mammary control of zinc secretion. J. Pediatr. 1984 Oct; 105(4): 600-2. PMID: 6548259, ISSN: 0022-3476.

Moran JR, Courtney ME, Orth DN, Vaughan R, Coy S, Mount CD, Sherrell BJ, Greene HL. Epidermal growth factor in human milk: daily production and diurnal variation during early lactation in mothers delivering at term and at premature gestation. J. Pediatr. 1983 Sep; 103(3): 402-5. PMID: 6604147, ISSN: 0022-3476.

Courtney ME, Greene HL, Folk CC, Helinek GL, Dmitruk A. Rapidly declining serum albumin values in newly hospitalized patients: prevalence, severity, and contributory factors. JPEN J Parenter Enteral Nutr. 1982 Mar; 6(2): 143-5. PMID: 6808174, ISSN: 0148-6071.

Greene HL, Helinek GL, Folk CC, Courtney M, Thompson S, MacDonell RC, Lukens JN. Nasogastric tube feeding at home: a method for adjunctive nutritional support of malnourished patients. Am. J. Clin. Nutr. 1981 Jun; 34(6): 1131-8. PMID: 6786077, ISSN: 0002-9165.