Marcela Brissova, Ph.D.

Research Associate Professor

marcela.brissova@vanderbilt.edu
Faculty Appointments
Research Associate Professor of Medicine
Education
Ph.D., Polymer chemistry, Slovak Technical University, BratislavaM.S., Polymer Chemistry, Slovak Technical University, Bratislava
Office Address
715 PRB
2220 Pierce Avenue
Nashville, TN 37232
Publications
Zhu X, Hu R, Brissova M, Stein RW, Powers AC, Gu G, Kaverina I. Microtubules Negatively Regulate Insulin Secretion in Pancreatic ß Cells. Dev. Cell. 2015 Sep 9/28/2015; 34(6): 656-68. PMID: 26418295, PMCID: PMC4594944, PII: S1534-5807(15)00554-7, DOI: 10.1016/j.devcel.2015.08.020, ISSN: 1878-1551.

Brissova M, Shostak A, Fligner CL, Revetta FL, Washington MK, Powers AC, Hull RL. Human Islets Have Fewer Blood Vessels than Mouse Islets and the Density of Islet Vascular Structures Is Increased in Type 2 Diabetes. J. Histochem. Cytochem. 2015 Aug; 63(8): 637-45. PMID: 26216139, PMCID: PMC4530394, PII: 63/8/637, DOI: 10.1369/0022155415573324, ISSN: 1551-5044.

Burke SJ, May AL, Noland RC, Lu D, Brissova M, Powers AC, Sherrill EM, Karlstad MD, Campagna SR, Stephens JM, Collier JJ. Thiobenzothiazole-modified Hydrocortisones Display Anti-inflammatory Activity with Reduced Impact on Islet ß-Cell Function. J. Biol. Chem [print-electronic]. 2015 May 5/22/2015; 290(21): 13401-16. PMID: 25851902, PMCID: PMC4505588, PII: M114.632190, DOI: 10.1074/jbc.M114.632190, ISSN: 1083-351X.

Kayton NS, Poffenberger G, Henske J, Dai C, Thompson C, Aramandla R, Shostak A, Nicholson W, Brissova M, Bush WS, Powers AC. Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2015 Apr 4/1/2015; 308(7): E592-602. PMID: 25648831, PMCID: PMC4385877, PII: ajpendo.00437.2014, DOI: 10.1152/ajpendo.00437.2014, ISSN: 1522-1555.

Barnes TM, Otero YF, Elliott AD, Locke AD, Malabanan CM, Coldren AG, Brissova M, Piston DW, McGuinness OP. Interleukin-6 amplifies glucagon secretion: coordinated control via the brain and pancreas. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2014 Nov 11/15/2014; 307(10): E896-905. PMID: 25205821, PMCID: PMC4233256, PII: ajpendo.00343.2014, DOI: 10.1152/ajpendo.00343.2014, ISSN: 1522-1555.

Golson ML, Bush WS, Brissova M. Automated quantification of pancreatic ß-cell mass. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2014 Jun 6/15/2014; 306(12): E1460-7. PMID: 24760991, PMCID: PMC4059986, PII: ajpendo.00591.2013, DOI: 10.1152/ajpendo.00591.2013, ISSN: 1522-1555.

Hang Y, Yamamoto T, Benninger RK, Brissova M, Guo M, Bush W, Piston DW, Powers AC, Magnuson M, Thurmond DC, Stein R. The MafA transcription factor becomes essential to islet ß-cells soon after birth. Diabetes [print-electronic]. 2014 Jun; 63(6): 1994-2005. PMID: 24520122, PMCID: PMC4030115, PII: db13-1001, DOI: 10.2337/db13-1001, ISSN: 1939-327X.

Reinert RB, Cai Q, Hong JY, Plank JL, Aamodt K, Prasad N, Aramandla R, Dai C, Levy SE, Pozzi A, Labosky PA, Wright CV, Brissova M, Powers AC. Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding. Development [print-electronic]. 2014 Apr; 141(7): 1480-91. PMID: 24574008, PMCID: PMC3957372, PII: dev.098657, DOI: 10.1242/dev.098657, ISSN: 1477-9129.

Pan FC, Brissova M. Pancreas development in humans. Curr Opin Endocrinol Diabetes Obes. 2014 Apr; 21(2): 77-82. PMID: 24569548, PII: 01266029-201404000-00002, DOI: 10.1097/MED.0000000000000047, ISSN: 1752-2978.

Brissova M, Aamodt K, Brahmachary P, Prasad N, Hong JY, Dai C, Mellati M, Shostak A, Poffenberger G, Aramandla R, Levy SE, Powers AC. Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes ß cell regeneration. Cell Metab [print-electronic]. 2014 Mar 3/4/2014; 19(3): 498-511. PMID: 24561261, PMCID: PMC4012856, PII: S1550-4131(14)00057-6, DOI: 10.1016/j.cmet.2014.02.001, ISSN: 1932-7420.

Reinert RB, Brissova M, Shostak A, Pan FC, Poffenberger G, Cai Q, Hundemer GL, Kantz J, Thompson CS, Dai C, McGuinness OP, Powers AC. Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets. Diabetes [print-electronic]. 2013 Dec; 62(12): 4154-64. PMID: 23884891, PMCID: PMC3837071, PII: db13-0071, DOI: 10.2337/db13-0071, ISSN: 1939-327X.

Dai C, Brissova M, Reinert RB, Nyman L, Liu EH, Thompson C, Shostak A, Shiota M, Takahashi T, Powers AC. Pancreatic islet vasculature adapts to insulin resistance through dilation and not angiogenesis. Diabetes [print-electronic]. 2013 Dec; 62(12): 4144-53. PMID: 23630302, PMCID: PMC3837044, PII: db12-1657, DOI: 10.2337/db12-1657, ISSN: 1939-327X.

Cai Q, Brissova M, Reinert RB, Pan FC, Brahmachary P, Jeansson M, Shostak A, Radhika A, Poffenberger G, Quaggin SE, Jerome WG, Dumont DJ, Powers AC. Enhanced expression of VEGF-A in ß cells increases endothelial cell number but impairs islet morphogenesis and ß cell proliferation. Dev. Biol [print-electronic]. 2012 Jul 7/1/2012; 367(1): 40-54. PMID: 22546694, PMCID: PMC3391601, PII: S0012-1606(12)00211-4, DOI: 10.1016/j.ydbio.2012.04.022, ISSN: 1095-564X.

Dai C, Brissova M, Hang Y, Thompson C, Poffenberger G, Shostak A, Chen Z, Stein R, Powers AC. Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets. Diabetologia [print-electronic]. 2012 Mar; 55(3): 707-18. PMID: 22167125, PMCID: PMC3268985, DOI: 10.1007/s00125-011-2369-0, ISSN: 1432-0428.

Reinert RB, Kantz J, Misfeldt AA, Poffenberger G, Gannon M, Brissova M, Powers AC. Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice. PLoS ONE [print-electronic]. 2012; 7(3): e33529. PMID: 22470452, PMCID: PMC3314663, PII: PONE-D-11-23105, DOI: 10.1371/journal.pone.0033529, ISSN: 1932-6203.

Luther JM, Luo P, Kreger MT, Brissova M, Dai C, Whitfield TT, Kim HS, Wasserman DH, Powers AC, Brown NJ. Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets. Diabetologia [print-electronic]. 2011 Aug; 54(8): 2152-63. PMID: 21519965, PMCID: PMC3216479, DOI: 10.1007/s00125-011-2158-9, ISSN: 1432-0428.

Zhao A, Ohara-Imaizumi M, Brissova M, Benninger RK, Xu Y, Hao Y, Abramowitz J, Boulay G, Powers AC, Piston D, Jiang M, Nagamatsu S, Birnbaumer L, Gu G. Gao represses insulin secretion by reducing vesicular docking in pancreatic beta-cells. Diabetes [print-electronic]. 2010 Oct; 59(10): 2522-9. PMID: 20622165, PMCID: PMC3279551, PII: db09-1719, DOI: 10.2337/db09-1719, ISSN: 1939-327X.

Virostko J, Radhika A, Poffenberger G, Chen Z, Brissova M, Gilchrist J, Coleman B, Gannon M, Jansen ED, Powers AC. Bioluminescence imaging in mouse models quantifies beta cell mass in the pancreas and after islet transplantation. Mol Imaging Biol [print-electronic]. 2010 Jan; 12(1): 42-53. PMID: 19548035, PMCID: PMC3822006, DOI: 10.1007/s11307-009-0240-1, ISSN: 1860-2002.

Nyman LR, Wells KS, Head WS, McCaughey M, Ford E, Brissova M, Piston DW, Powers AC. Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets. J. Clin. Invest [print-electronic]. 2008 Nov; 118(11): 3790-7. PMID: 18846254, PMCID: PMC2564611, DOI: 10.1172/JCI36209, ISSN: 0021-9738.

Brissova M, Powers AC. Revascularization of transplanted islets: can it be improved?. Diabetes. 2008 Sep; 57(9): 2269-71. PMID: 18753672, PMCID: PMC2518476, PII: 57/9/2269, DOI: 10.2337/db08-0814, ISSN: 1939-327X.