Agnes B. Fogo, M.D.

Faculty Appointments
Professor of Pathology, Microbiology and Immunology John L. Shapiro Chair in PathologyProfessor of PediatricsProfessor of Medicine
M.D., Medicine, Vanderbilt University, Nashville, TennesseeB.A., University of Tennessee, Chattanooga, Tennessee
Office Address
C-3310 MCN
TN 2561
Research Description
Research efforts primarily concern renal pathology and involve: 1) basic research in mechanisms and pathophysiology of progression of chronic renal disease; including regression/remodeling of sclerosis; 2) basic research in mechanisms and pathophysiology of the renin angiotensin system; and 3) applied renal pathology with emphasis on prognostic features in minimal change disease/focal glomerulosclerosis.

Chronic rat animal models and knock-out mice are used to investigate the interactions of fibrotic and thrombotic mechanisms. Our work focuses on contributions of the renin angiotensin system to structural damage, and its interactions with other growth factors, and with mechanisms of thrombosis (i.e. plasmin/plasminogen activator system). Approaches include classical pathology, molecular biology and functional assessments. .
Research Keywords
progression of kidney disease angiotensin PAI-1 regression of sclerosis
Clinical Research Keywords
kidney biopsy
Wallace E, Fogo AB, Schulman G. Imatinib therapy for non-infection-related type II cryoglobulinemia with membranoproliferative glomerulonephritis. Am. J. Kidney Dis [print-electronic]. 2012 Jan; 59(1): 122-5. PMID: 21982457, PII: S0272-6386(11)01271-6, DOI: 10.1053/j.ajkd.2011.08.016, ISSN: 1523-6838.

Zuo Y, Yang HC, Potthoff SA, Najafian B, Kon V, Ma LJ, Fogo AB. Protective effects of PPAR¿ agonist in acute nephrotic syndrome. Nephrol. Dial. Transplant [print-electronic]. 2012 Jan; 27(1): 174-81. PMID: 21565943, PMCID: PMC3276311, PII: gfr240, DOI: 10.1093/ndt/gfr240, ISSN: 1460-2385.

Yamamoto S, Yancey PG, Zuo Y, Ma LJ, Kaseda R, Fogo AB, Ichikawa I, Linton MF, Fazio S, Kon V. Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2011 Dec; 31(12): 2856-64. PMID: 21979434, PMCID: PMC3227118, PII: ATVBAHA.111.237198, DOI: 10.1161/ATVBAHA.111.237198, ISSN: 1524-4636.

Yang HC, Rossini M, Ma LJ, Zuo Y, Ma J, Fogo AB. Cells derived from young bone marrow alleviate renal aging. J. Am. Soc. Nephrol [print-electronic]. 2011 Nov; 22(11): 2028-36. PMID: 21965376, PMCID: PMC3231782, PII: ASN.2010090982, DOI: 10.1681/ASN.2010090982, ISSN: 1533-3450.

Basford AW, Lewis J, Dwyer JP, Fogo AB. Membranous nephropathy with crescents. J. Am. Soc. Nephrol [print-electronic]. 2011 Oct; 22(10): 1804-8. PMID: 21903992, PII: ASN.2010090923, DOI: 10.1681/ASN.2010090923, ISSN: 1533-3450.

Yamamoto S, Zuo Y, Ma J, Yancey PG, Hunley TE, Motojima M, Fogo AB, Linton MF, Fazio S, Ichikawa I, Kon V. Oral activated charcoal adsorbent (AST-120) ameliorates extent and instability of atherosclerosis accelerated by kidney disease in apolipoprotein E-deficient mice. Nephrol. Dial. Transplant [print-electronic]. 2011 Aug; 26(8): 2491-7. PMID: 21245127, PMCID: PMC3203394, PII: gfq759, DOI: 10.1093/ndt/gfq759, ISSN: 1460-2385.

Ma J, Matsusaka T, Yang HC, Zhong J, Takagi N, Fogo AB, Kon V, Ichikawa I. Induction of podocyte-derived VEGF ameliorates podocyte injury and subsequent abnormal glomerular development caused by puromycin aminonucleoside. Pediatr. Res. 2011 Jul; 70(1): 83-9. PMID: 21451433, PMCID: PMC3113658, DOI: 10.1203/PDR.0b013e31821bdf1c, ISSN: 1530-0447.

Fogo AB. The targeted podocyte. J. Clin. Invest [print-electronic]. 2011 Jun; 121(6): 2142-5. PMID: 21606599, PMCID: PMC3104780, PII: 57935, DOI: 10.1172/JCI57935, ISSN: 1558-8238.

Ma LJ, Corsa BA, Zhou J, Yang H, Li H, Tang YW, Babaev VR, Major AS, Linton MF, Fazio S, Hunley TE, Kon V, Fogo AB. Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity. Am. J. Physiol. Renal Physiol [print-electronic]. 2011 May; 300(5): F1203-13. PMID: 21367915, PMCID: PMC3094053, PII: ajprenal.00468.2010, DOI: 10.1152/ajprenal.00468.2010, ISSN: 1522-1466.

Scruggs BS, Zuo Y, Donnert E, Ma L, Bertram JF, Fogo AB. Increased capillary branching contributes to angiotensin type 1 receptor blocker (ARB)-induced regression of sclerosis. Am. J. Pathol [print-electronic]. 2011 Apr; 178(4): 1891-8. PMID: 21406166, PMCID: PMC3078453, PII: S0002-9440(11)00017-4, DOI: 10.1016/j.ajpath.2010.12.029, ISSN: 1525-2191.

Fogo AB. PPAR¿ and chronic kidney disease. Pediatr. Nephrol [print-electronic]. 2011 Mar; 26(3): 347-51. PMID: 20676693, DOI: 10.1007/s00467-010-1602-2, ISSN: 1432-198X.

Yang H, Fogo AB. Cell senescence in the aging kidney. J. Am. Soc. Nephrol [print-electronic]. 2010 Sep; 21(9): 1436-9. PMID: 20705707, PII: ASN.2010020205, DOI: 10.1681/ASN.2010020205, ISSN: 1533-3450.

Fogo AB, Kon V. The glomerulus--a view from the inside--the endothelial cell. Int. J. Biochem. Cell Biol [print-electronic]. 2010 Sep; 42(9): 1388-97. PMID: 20541032, PII: S1357-2725(10)00195-0, DOI: 10.1016/j.biocel.2010.05.015, ISSN: 1878-5875.

Pedchenko V, Bondar O, Fogo AB, Vanacore R, Voziyan P, Kitching AR, Wieslander J, Kashtan C, Borza DB, Neilson EG, Wilson CB, Hudson BG. Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis. N. Engl. J. Med. 2010 Jul 7/22/2010; 363(4): 343-54. PMID: 20660402, PMCID: PMC4144421, PII: 363/4/343, DOI: 10.1056/NEJMoa0910500, ISSN: 1533-4406.

Fogo AB, Bostad L, Svarstad E, Cook WJ, Moll S, Barbey F, Geldenhuys L, West M, Ferluga D, Vujkovac B, Howie AJ, Burns A, Reeve R, Waldek S, Noël LH, Grünfeld JP, Valbuena C, Oliveira JP, Müller J, Breunig F, Zhang X, Warnock DG, . Scoring system for renal pathology in Fabry disease: report of the International Study Group of Fabry Nephropathy (ISGFN). Nephrol. Dial. Transplant [print-electronic]. 2010 Jul; 25(7): 2168-77. PMID: 19833663, PMCID: PMC2902894, PII: gfp528, DOI: 10.1093/ndt/gfp528, ISSN: 1460-2385.

Rossini M, Naito T, Yang H, Freeman M, Donnert E, Ma LJ, Dunn SR, Sharma K, Fogo AB. Sulodexide ameliorates early but not late kidney disease in models of radiation nephropathy and diabetic nephropathy. Nephrol. Dial. Transplant [print-electronic]. 2010 Jun; 25(6): 1803-10. PMID: 20061322, PMCID: PMC2902889, PII: gfp724, DOI: 10.1093/ndt/gfp724, ISSN: 1460-2385.

He W, Wang Y, Zhang MZ, You L, Davis LS, Fan H, Yang HC, Fogo AB, Zent R, Harris RC, Breyer MD, Hao CM. Sirt1 activation protects the mouse renal medulla from oxidative injury. J. Clin. Invest [print-electronic]. 2010 Apr; 120(4): 1056-68. PMID: 20335659, PMCID: PMC2846063, PII: 41563, DOI: 10.1172/JCI41563, ISSN: 1558-8238.

Matsusaka T, Asano T, Niimura F, Kinomura M, Shimizu A, Shintani A, Pastan I, Fogo AB, Ichikawa I. Angiotensin receptor blocker protection against podocyte-induced sclerosis is podocyte angiotensin II type 1 receptor-independent. Hypertension [print-electronic]. 2010 Apr; 55(4): 967-73. PMID: 20142565, PMCID: PMC2887658, PII: HYPERTENSIONAHA.109.141994, DOI: 10.1161/HYPERTENSIONAHA.109.141994, ISSN: 1524-4563.

Naito T, Ma LJ, Yang H, Zuo Y, Tang Y, Han JY, Kon V, Fogo AB. Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis. Am. J. Physiol. Renal Physiol [print-electronic]. 2010 Mar; 298(3): F683-91. PMID: 20042458, PMCID: PMC2838584, PII: 00503.2009, DOI: 10.1152/ajprenal.00503.2009, ISSN: 1522-1466.

Yang HC, Zuo Y, Fogo AB. Models of chronic kidney disease. Drug Discov Today Dis Models. 2010; 7(1-2): 13-9. PMID: 21286234, PMCID: PMC3030258, DOI: 10.1016/j.ddmod.2010.08.002, ISSN: 1740-6757.

Kanjanabuch T, Ma LJ, Chen J, Pozzi A, Guan Y, Mundel P, Fogo AB. PPAR-gamma agonist protects podocytes from injury. Kidney Int [print-electronic]. 2007 Jun; 71(12): 1232-9. PMID: 17457378, PII: 5002248, DOI: 10.1038/, ISSN: 0085-2538.

Breyer MD, Tchekneva E, Qi Z, Takahashi T, Fogo AB, Zhao HJ, Harris RC. Genetics of diabetic nephropathy: lessons from mice. Semin. Nephrol. 2007 Mar; 27(2): 237-47. PMID: 17418691, PII: S0270-9295(07)00002-2, DOI: 10.1016/j.semnephrol.2007.01.001, ISSN: 0270-9295.

Dwyer JP, Yates KM, Sumner EL, Stone WJ, Wang Y, Koury MJ, Fogo AB, Zent R. Chronic myeloid leukemia-associated membranoproliferative glomerulonephritis that responded to imatinib mesylate therapy. Clin. Nephrol. 2007 Mar; 67(3): 176-81. PMID: 17390742, ISSN: 0301-0430.

Tchekneva EE, Rinchik EM, Polosukhina D, Davis LS, Kadkina V, Mohamed Y, Dunn SR, Sharma K, Qi Z, Fogo AB, Breyer MD. A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy. J. Am. Soc. Nephrol [print-electronic]. 2007 Jan; 18(1): 103-12. PMID: 17151334, PII: ASN.2006020164, DOI: 10.1681/ASN.2006020164, ISSN: 1046-6673.

Zuo Y, Matsusaka T, Zhong J, Ma J, Ma LJ, Hanna Z, Jolicoeur P, Fogo AB, Ichikawa I. HIV-1 genes vpr and nef synergistically damage podocytes, leading to glomerulosclerosis. J. Am. Soc. Nephrol [print-electronic]. 2006 Oct; 17(10): 2832-43. PMID: 16988066, PII: ASN.2005080878, DOI: 10.1681/ASN.2005080878, ISSN: 1046-6673.

Zhao HJ, Wang S, Cheng H, Zhang MZ, Takahashi T, Fogo AB, Breyer MD, Harris RC. Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. J. Am. Soc. Nephrol [print-electronic]. 2006 Oct; 17(10): 2664-9. PMID: 16971655, PMCID: PMC4618687, PII: ASN.2006070798, DOI: 10.1681/ASN.2006070798, ISSN: 1046-6673.

Fogo AB. The clot thickens. Kidney Int. 2006 Aug; 70(4): 620-1. PMID: 16900220, PII: 5001721, DOI: 10.1038/, ISSN: 0085-2538.

Schaefer HM, Helderman JH, Fogo AB. Slow decline in allograft function in a renal transplant patient. Am. J. Kidney Dis. 2006 Aug; 48(2): 335-8. PMID: 16860203, PII: S0272-6386(06)00943-7, DOI: 10.1053/j.ajkd.2006.02.193, ISSN: 1523-6838.

Liang XB, Ma LJ, Naito T, Wang Y, Madaio M, Zent R, Pozzi A, Fogo AB. Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J. Am. Soc. Nephrol [print-electronic]. 2006 Jul; 17(7): 1886-95. PMID: 16790514, PII: ASN.2005020205, DOI: 10.1681/ASN.2005020205, ISSN: 1046-6673.

Fogo AB. Can glomerulosclerosis be reversed?. Nat Clin Pract Nephrol. 2006 Jun; 2(6): 290-1. PMID: 16932443, PII: ncpneph0200, DOI: 10.1038/ncpneph0200, ISSN: 1745-8323.

Yang HC, Ma LJ, Ma J, Fogo AB. Peroxisome proliferator-activated receptor-gamma agonist is protective in podocyte injury-associated sclerosis. Kidney Int. 2006 May; 69(10): 1756-64. PMID: 16598202, PII: 5000336, DOI: 10.1038/, ISSN: 0085-2538.

Ma J, Weisberg A, Griffin JP, Vaughan DE, Fogo AB, Brown NJ. Plasminogen activator inhibitor-1 deficiency protects against aldosterone-induced glomerular injury. Kidney Int. 2006 Mar; 69(6): 1064-72. PMID: 16528256, PII: 5000201, DOI: 10.1038/, ISSN: 0085-2538.

Suganuma E, Zuo Y, Ayabe N, Ma J, Babaev VR, Linton MF, Fazio S, Ichikawa I, Fogo AB, Kon V. Antiatherogenic effects of angiotensin receptor antagonism in mild renal dysfunction. J. Am. Soc. Nephrol [print-electronic]. 2006 Feb; 17(2): 433-41. PMID: 16371432, PII: ASN.2005080883, DOI: 10.1681/ASN.2005080883, ISSN: 1046-6673.

Ayabe N, Babaev VR, Tang Y, Tanizawa T, Fogo AB, Linton MF, Ichikawa I, Fazio S, Kon V. Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice. Atherosclerosis [print-electronic]. 2006 Feb; 184(2): 312-21. PMID: 16023123, PII: S0021-9150(05)00312-6, DOI: 10.1016/j.atherosclerosis.2005.05.016, ISSN: 0021-9150.

Liang X, Kanjanabuch T, Mao SL, Hao CM, Tang YW, Declerck PJ, Hasty AH, Wasserman DH, Fogo AB, Ma LJ. Plasminogen activator inhibitor-1 modulates adipocyte differentiation. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2006 Jan; 290(1): E103-E113. PMID: 16144810, PII: 00605.2004, DOI: 10.1152/ajpendo.00605.2004, ISSN: 0193-1849.

Rossini M, Cheunsuchon B, Donnert E, Ma LJ, Thomas JW, Neilson EG, Fogo AB. Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal disease. Kidney Int. 2005 Dec; 68(6): 2621-8. PMID: 16316338, PII: KID734, DOI: 10.1111/j.1523-1755.2005.00734.x, ISSN: 0085-2538.

Wang XP, Fogo AB, Colon S, Giannico G, Abul-Ezz SR, Miner JH, Borza DB. Distinct epitopes for anti-glomerular basement membrane alport alloantibodies and goodpasture autoantibodies within the noncollagenous domain of alpha3(IV) collagen: a janus-faced antigen. J. Am. Soc. Nephrol [print-electronic]. 2005 Dec; 16(12): 3563-71. PMID: 16236801, PII: ASN.2005060670, DOI: 10.1681/ASN.2005060670, ISSN: 1046-6673.

Revelo MP, Federspiel C, Helderman H, Fogo AB. Chronic allograft nephropathy: expression and localization of PAI-1 and PPAR-gamma. Nephrol. Dial. Transplant [print-electronic]. 2005 Dec; 20(12): 2812-9. PMID: 16221712, PII: gfi172, DOI: 10.1093/ndt/gfi172, ISSN: 0931-0509.

Rossini M, Coventry S, Duff DR, Fogo AB. Chronic renal failure and abnormal tubular cells in 2 siblings. Am. J. Kidney Dis. 2005 Nov; 46(5): 982-7. PMID: 16253744, PII: S0272-6386(05)01219-9, DOI: 10.1053/j.ajkd.2005.04.040, ISSN: 1523-6838.

Aldigier JC, Kanjanbuch T, Ma LJ, Brown NJ, Fogo AB. Regression of existing glomerulosclerosis by inhibition of aldosterone. J. Am. Soc. Nephrol [print-electronic]. 2005 Nov; 16(11): 3306-14. PMID: 16192423, PII: ASN.2004090804, DOI: 10.1681/ASN.2004090804, ISSN: 1046-6673.

Xu BJ, Shyr Y, Liang X, Ma LJ, Donnert EM, Roberts JD, Zhang X, Kon V, Brown NJ, Caprioli RM, Fogo AB. Proteomic patterns and prediction of glomerulosclerosis and its mechanisms. J. Am. Soc. Nephrol [print-electronic]. 2005 Oct; 16(10): 2967-75. PMID: 16079267, PII: ASN.2005030262, DOI: 10.1681/ASN.2005030262, ISSN: 1046-6673.

Gökden N, Rossini M, Kumar J, Fogo AB. Membranoproliferative injury pattern in a renal allograft. Am. J. Kidney Dis. 2005 Sep; 46(3): 573-6. PMID: 16129221, PII: S0272-6386(05)00858-9, DOI: 10.1053/j.ajkd.2005.03.026, ISSN: 1523-6838.

Qi Z, Fujita H, Jin J, Davis LS, Wang Y, Fogo AB, Breyer MD. Characterization of susceptibility of inbred mouse strains to diabetic nephropathy. Diabetes. 2005 Sep; 54(9): 2628-37. PMID: 16123351, PII: 54/9/2628, ISSN: 0012-1797.

Zhong J, Zuo Y, Ma J, Fogo AB, Jolicoeur P, Ichikawa I, Matsusaka T. Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy. Kidney Int. 2005 Sep; 68(3): 1048-60. PMID: 16105035, PII: KID497, DOI: 10.1111/j.1523-1755.2005.00497.x, ISSN: 0085-2538.

Fogo AB. New capillary growth: a contributor to regression of sclerosis?. Curr. Opin. Nephrol. Hypertens. 2005 May; 14(3): 201-3. PMID: 15821410, PII: 00041552-200505000-00002, ISSN: 1062-4821.

Matsusaka T, Xin J, Niwa S, Kobayashi K, Akatsuka A, Hashizume H, Wang QC, Pastan I, Fogo AB, Ichikawa I. Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury. J. Am. Soc. Nephrol [print-electronic]. 2005 Apr; 16(4): 1013-23. PMID: 15758046, PII: ASN.2004080720, DOI: 10.1681/ASN.2004080720, ISSN: 1046-6673.

Ma LJ, Nakamura S, Aldigier JC, Rossini M, Yang H, Liang X, Nakamura I, Marcantoni C, Fogo AB. Regression of glomerulosclerosis with high-dose angiotensin inhibition is linked to decreased plasminogen activator inhibitor-1. J. Am. Soc. Nephrol [print-electronic]. 2005 Apr; 16(4): 966-76. PMID: 15728787, PII: ASN.2004060492, DOI: 10.1681/ASN.2004060492, ISSN: 1046-6673.

Basi S, Schulman G, Fogo AB. Multiple complications in multiple myeloma. Am. J. Kidney Dis. 2005 Mar; 45(3): 619-23. PMID: 15754288, PII: S0272638604016932, DOI: 10.1053/j.ajkd.2004.07.026, ISSN: 1523-6838.

Weisberg AD, Albornoz F, Griffin JP, Crandall DL, Elokdah H, Fogo AB, Vaughan DE, Brown NJ. Pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 attenuates angiotensin II/salt-induced aortic remodeling. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2005 Feb; 25(2): 365-71. PMID: 15576638, PII: 01.ATV.0000152356.85791.52, DOI: 10.1161/01.ATV.0000152356.85791.52, ISSN: 1524-4636.

Hunley TE, Corzo D, Dudek M, Kishnani P, Amalfitano A, Chen YT, Richards SM, Phillips JA, Fogo AB, Tiller GE. Nephrotic syndrome complicating alpha-glucosidase replacement therapy for Pompe disease. Pediatrics. 2004 Oct; 114(4): e532-5. PMID: 15466083, PII: 114/4/e532, DOI: 10.1542/peds.2003-0988-L, ISSN: 1098-4275.

Wang Y, Fogo AB. Quiz page. Anti-GBM antibody-mediated glomerulonephritis with superimposed ANCA-associated vasculitis. Am. J. Kidney Dis. 2004 Sep; 44(3): A45, e31-2. PMID: 15332235, PII: S0272638604008662, ISSN: 1523-6838.

Chen X, Moeckel G, Morrow JD, Cosgrove D, Harris RC, Fogo AB, Zent R, Pozzi A. Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am. J. Pathol. 2004 Aug; 165(2): 617-30. PMID: 15277235, PMCID: PMC1618576, PII: S0002-9440(10)63326-3, ISSN: 0002-9440.

Fogo AB, Rossini M, Lazin A. Quiz page. Light chain cast nephropathy. Am. J. Kidney Dis. 2004 Jul; 44(1): A45, e1-2. PMID: 15211453, PII: S0272638604005773, ISSN: 1523-6838.

Good KS, O'Brien K, Schulman G, Kerjaschki D, Fogo AB. Unexplained nephrotic-range proteinuria in a 38-year-old man: a case of "no change disease". Am. J. Kidney Dis. 2004 May; 43(5): 933-8. PMID: 15112187, PII: S0272638604001489, ISSN: 1523-6838.

Milstone A, Vilchez RA, Geiger X, Fogo AB, Butel JS, Dummer S. Polyomavirus simian virus 40 infection associated with nephropathy in a lung-transplant recipient. Transplantation. 2004 Apr 4/15/2004; 77(7): 1019-24. PMID: 15087764, PII: 00007890-200404150-00011, ISSN: 0041-1337.

Wang Y, Rossini M, Fogo AB. Quiz page. HIV-associated nephropathy is the overwhelmingly most likely diagnosis. Am. J. Kidney Dis. 2004 Apr; 43(4): A47-e1. PMID: 15042560, PII: S0272638604001192, ISSN: 1523-6838.

Qi Z, Whitt I, Mehta A, Jin J, Zhao M, Harris RC, Fogo AB, Breyer MD. Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance. Am. J. Physiol. Renal Physiol [print-electronic]. 2004 Mar; 286(3): F590-6. PMID: 14600035, PII: 00324.2003, DOI: 10.1152/ajprenal.00324.2003, ISSN: 1931-857X.

Ma LJ, Mao SL, Taylor KL, Kanjanabuch T, Guan Y, Zhang Y, Brown NJ, Swift LL, McGuinness OP, Wasserman DH, Vaughan DE, Fogo AB. Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes. 2004 Feb; 53(2): 336-46. PMID: 14747283, ISSN: 0012-1797.

Ma LJ, Jha S, Ling H, Pozzi A, Ledbetter S, Fogo AB. Divergent effects of low versus high dose anti-TGF-beta antibody in puromycin aminonucleoside nephropathy in rats. Kidney Int. 2004 Jan; 65(1): 106-15. PMID: 14675041, DOI: 10.1111/j.1523-1755.2004.00381.x, ISSN: 0085-2538.

Fogo AB, Rossini M. Monoclonal immunoglobin deposition disease, heavy chain deposition type. Am. J. Kidney Dis. 2003 Dec; 42(6): A48, E1-2. PMID: 14655222, PII: S0272638603012034, ISSN: 1523-6838.

Fogo AB. Approach to renal biopsy. Am. J. Kidney Dis. 2003 Oct; 42(4): 826-36. PMID: 14520635, PII: S0272638603010540, ISSN: 1523-6838.

Ma LJ, Yang H, Gaspert A, Carlesso G, Barty MM, Davidson JM, Sheppard D, Fogo AB. Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am. J. Pathol. 2003 Oct; 163(4): 1261-73. PMID: 14507636, PMCID: PMC1868298, PII: S0002-9440(10)63486-4, ISSN: 0002-9440.

Fogo AB. Renal fibrosis: not just PAI-1 in the sky. J. Clin. Invest. 2003 Aug; 112(3): 326-8. PMID: 12897200, PMCID: PMC166301, PII: 112/3/326, DOI: 10.1172/JCI19375, ISSN: 0021-9738.

Fogo AB. Quiz page. Acute interstitial nephritis and minimal change disease lesion, caused by NSAID injury. Am. J. Kidney Dis. 2003 Aug; 42(2): A41-E1. PMID: 12900841, PII: S0272638603006838, ISSN: 1523-6838.

Paueksakon P, Revelo MP, Horn RG, Shappell S, Fogo AB. Monoclonal gammopathy: significance and possible causality in renal disease. Am. J. Kidney Dis. 2003 Jul; 42(1): 87-95. PMID: 12830460, PII: S0272638603004128, ISSN: 1523-6838.

Ma LJ, Fogo AB. Model of robust induction of glomerulosclerosis in mice: importance of genetic background. Kidney Int. 2003 Jul; 64(1): 350-5. PMID: 12787428, PII: kid058, DOI: 10.1046/j.1523-1755.2003.00058.x, ISSN: 0085-2538.

Fogo AB. Quiz page. Diabetic nephropathy with superimposed acute interstitial nephritis. Am. J. Kidney Dis. 2003 Jun; 41(6): A47, E1-3. PMID: 12776302, PII: S0272638603005146, ISSN: 1523-6838.

Moeckel GW, Zhang L, Fogo AB, Hao CM, Pozzi A, Breyer MD. COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress. J. Biol. Chem [print-electronic]. 2003 May 5/23/2003; 278(21): 19352-7. PMID: 12637551, PII: M302209200, DOI: 10.1074/jbc.M302209200, ISSN: 0021-9258.

Fogo AB. The potential for regression of renal scarring [editorial]. Curr. Opin. Nephrol. Hypertens. 2003 May; 12(3): 223-5. PMID: 12698058, DOI: 10.1097/01.mnh.0000069854.94246.3e, ISSN: 1062-4821.

Fogo AB. Animal models of FSGS: lessons for pathogenesis and treatment. Semin. Nephrol. 2003 Mar; 23(2): 161-71. PMID: 12704576, PII: S0270929503700187, DOI: 10.1053/snep.2003.50015, ISSN: 0270-9295.

Fogo AB. Quiz page. Proliferative glomerulonephritis. Am. J. Kidney Dis. 2003 Mar; 41(3): xlvii. PMID: 12621658, ISSN: 1523-6838.

Fogo AB. Hypertensive risk factors in kidney disease in African Americans. Kidney Int. Suppl. 2003 Feb; (83): S17-21. PMID: 12864869, PII: kid8304, DOI: 10.1046/j.1523-1755.63.s83.5.x, ISSN: 0098-6577.

Chang IJ, Cheunsuchon B, Miller FJ, Fogo AB. A 66-year-old woman with progressive renal insufficiency, nephrotic syndrome, and monoclonal protein. Am. J. Kidney Dis. 2003 Feb; 41(2): 508-17. PMID: 12552518, PII: S0272638602691991, DOI: 10.1053/ajkd.2003.50112, ISSN: 1523-6838.

Nishida M, Fujinaka H, Matsusaka T, Price J, Kon V, Fogo AB, Davidson JM, Linton MF, Fazio S, Homma T, Yoshida H, Ichikawa I. Absence of angiotensin II type 1 receptor in bone marrow-derived cells is detrimental in the evolution of renal fibrosis. J. Clin. Invest. 2002 Dec; 110(12): 1859-68. PMID: 12488436, PMCID: PMC151648, DOI: 10.1172/JCI15045, ISSN: 0021-9738.

Fogo AB. Quiz page. Mesangial lupus nephritis, WHO IIb, and severe acute tubular necrosis, secondary to gentamycin toxicity. Am. J. Kidney Dis. 2002 Nov; 40(5): xlix. PMID: 12408173, ISSN: 1523-6838.

Brown NJ, Vaughan DE, Fogo AB. The renin-angiotensin-aldosterone system and fibrinolysis in progressive renal disease. Semin. Nephrol. 2002 Sep; 22(5): 399-406. PMID: 12224047, PII: S027092950250053X, ISSN: 0270-9295.

Fogo AB. Quiz page. Transplant glomerulopathy. Am. J. Kidney Dis. 2002 Sep; 40(3): xli. PMID: 12206157, ISSN: 1523-6838.

Fogo AB. Quiz page. Diabetic nephropathy and extensive, superimposed, intratubular, calcium oxalate crystals, due to enteric hyperoxaluria. Am. J. Kidney Dis. 2002 Aug; 40(2): xl. PMID: 12148125, PII: a35150, ISSN: 1523-6838.

Kaikita K, Schoenhard JA, Painter CA, Ripley RT, Brown NJ, Fogo AB, Vaughan DE. Potential roles of plasminogen activator system in coronary vascular remodeling induced by long-term nitric oxide synthase inhibition. J. Mol. Cell. Cardiol. 2002 Jun; 34(6): 617-27. PMID: 12054849, PII: S0022282802920018, DOI: 10.1006/jmcc.2002.2001, ISSN: 0022-2828.

Fogo AB. Quiz page. Light chain cast nephropathy with light chain deposition disease. Am. J. Kidney Dis. 2002 Jun; 39(6): xlii. PMID: 12049089, ISSN: 1523-6838.

Paueksakon P, Revelo MP, Ma LJ, Marcantoni C, Fogo AB. Microangiopathic injury and augmented PAI-1 in human diabetic nephropathy. Kidney Int. 2002 Jun; 61(6): 2142-8. PMID: 12028454, PII: kid384, DOI: 10.1046/j.1523-1755.2002.00384.x, ISSN: 0085-2538.

Brown NJ, Vaughan DE, Fogo AB. Aldosterone and PAI-1: implications for renal injury. J. Nephrol. 2002 May; 15(3): 230-5. PMID: 12113592, ISSN: 1121-8428.

Fogo AB. Quiz page. Fibrillary glomerulonephritis. Am. J. Kidney Dis. 2002 May; 39(5): liii. PMID: 12038447, ISSN: 1523-6838.

Fogo AB. Quiz page. AA amyloidosis. Am. J. Kidney Dis. 2002 Mar; 39(3): 444. PMID: 11881640, ISSN: 1523-6838.

Fogo AB. Quiz page. IgA nephropathy. Am. J. Kidney Dis. 2002 Feb; 39(2): xlviii. PMID: 11842831, ISSN: 1523-6838.

Moeckel GW, Jabs K, Fogo AB. An 11-year-old African-American girl with systemic lupus erythematosus and ANCA-negative renal vasculitis. Am. J. Kidney Dis. 2002 Feb; 39(2): 433-8. PMID: 11840389, PII: S0272-6386(02)55193-3, DOI: 10.1053/ajkd.2002.30568, ISSN: 1523-6838.

Nishida M, Fujinaka H, Matsusaka T, Price J, Kon V, Fogo AB, Davidson JM, Linton MF, Fazio S, Homma T, Yoshida H, Ichikawa I.. IAbsence of angiotensin II type 1 receptor in bone marrow-derived cells is detrimental in the evolution of renal fibrosis. J Clin Invest. 2002; 110: 1859-68.

Paueksakon P, Revelo MP, Ma L-j, Marcantoni C, Fogo AB.. Microangiopathic injury and augmented PAI-1 in human diabetic nephropathy. Kidney Int. 2002; 61: 2142-8.

Langone AJ, Revelo MP, Schulman G, Fogo AB. A young man with 20 years of nephrotic range proteinuria without loss of renal function. Am. J. Kidney Dis. 2001 Dec; 38(6): 1329-33. PMID: 11728970, PII: S0272-6386(01)09219-8, DOI: 10.1053/ajkd.2001.29243, ISSN: 1523-6838.

Fogo AB. Mechanisms in nephrosclerosis and hypertension-beyond hemodynamics. J. Nephrol. 2001 Nov; 14 Suppl 4: S63-9. PMID: 11798148, ISSN: 1121-8428.

Ma L, Fogo AB. Role of angiotensin II in glomerular injury. Semin. Nephrol. 2001 Nov; 21(6): 544-53. PMID: 11709802, PII: S0270929501000766, ISSN: 0270-9295.

Kaikita K, Fogo AB, Ma L, Schoenhard JA, Brown NJ, Vaughan DE. Plasminogen activator inhibitor-1 deficiency prevents hypertension and vascular fibrosis in response to long-term nitric oxide synthase inhibition. Circulation. 2001 Aug 8/14/2001; 104(7): 839-44. PMID: 11502712, ISSN: 1524-4539.

Ma LJ, Marcantoni C, Linton MF, Fazio S, Fogo AB. Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats. Kidney Int. 2001 May; 59(5): 1899-910. PMID: 11318962, PII: kid695, DOI: 10.1046/j.1523-1755.2001.0590051899.x, ISSN: 0085-2538.

Revelo MP, Staffeld C, Copley JB, Fogo AB. A 26-year-old man with kidney allograft failure and foot pain. Am. J. Kidney Dis. 2001 Apr; 37(4): 871-5. PMID: 11273891, PII: S0272638601573527, ISSN: 1523-6838.

Fogo AB. Progression and potential regression of glomerulosclerosis. Kidney Int. 2001 Feb; 59(2): 804-19. PMID: 11168971, PII: kid556, DOI: 10.1046/j.1523-1755.2001.059002804.x, ISSN: 0085-2538.

Ma LJ, Fogo AB. Angiotensin as inducer of plasminogen activator inhibitor-1 and fibrosis. Contrib Nephrol. 2001; (135): 161-70. PMID: 11705282, ISSN: 0302-5144.

Fogo AB. Renal fibrosis and the renin-angiotensin system. Adv. Nephrol. Necker Hosp. 2001; 31: 69-87. PMID: 11692472, ISSN: 0084-5957.

Fogo AB. Minimal change disease and focal segmental glomerulosclerosis. Nephrol. Dial. Transplant. 2001; 16 Suppl 6: 74-6. PMID: 11568250, ISSN: 0931-0509.

Fogo A. Progression and potential regression of glomerulosclerosis. Nephrology Forum. Kidney Int. 2001; 59: 804-19.

Ma LJ, Nakamura S, Whitsitt JS, Marcantoni C, Davidson JM, Fogo AB. Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1. Kidney Int. 2000 Dec; 58(6): 2425-36. PMID: 11115076, PII: kid426, DOI: 10.1046/j.1523-1755.2000.00426.x, ISSN: 0085-2538.

Fujinaka H, Miyazaki Y, Matsusaka T, Yoshida H, Fogo AB, Inagami T, Ichikawa I. Salutary role for angiotensin in partial urinary tract obstruction. Kidney Int. 2000 Nov; 58(5): 2018-27. PMID: 11044222, PII: kid374, DOI: 10.1111/j.1523-1755.2000.00374.x, ISSN: 0085-2538.

Revelo MP, Paueksakon P, Goral S, Helderman H, Fogo AB. A 14-year-old boy with kidney allograft failure in the first month after transplantation. Am. J. Kidney Dis. 2000 Oct; 36(4): 871-4. PMID: 11007695, PII: S0272638600398481, ISSN: 1523-6838.

Paueksakon P, Revelo M, Lee SM, Horn RG, Fogo AB. Acute renal failure in a 64-year-old white man. Am. J. Kidney Dis. 2000 Sep; 36(3): 669-74. PMID: 10977803, PII: S0272-6386(00)90007-6, DOI: 10.1053/ajkd.2000.16211, ISSN: 1523-6838.

Brown NJ, Nakamura S, Ma L, Nakamura I, Donnert E, Freeman M, Vaughan DE, Fogo AB. Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo. Kidney Int. 2000 Sep; 58(3): 1219-27. PMID: 10972684, PII: kid277, DOI: 10.1046/j.1523-1755.2000.00277.x, ISSN: 0085-2538.

Nakamura S, Nakamura I, Ma L, Vaughan DE, Fogo AB. Plasminogen activator inhibitor-1 expression is regulated by the angiotensin type 1 receptor in vivo. Kidney Int. 2000 Jul; 58(1): 251-9. PMID: 10886570, PII: kid160, DOI: 10.1046/j.1523-1755.2000.00160.x, ISSN: 0085-2538.

Revelo MP, Pauesakon P, Weidner M, Helderman JH, Horn RG, Fogo AB. A 37-year-old woman with systemic lupus erythematosus and acute allograft failure. Am. J. Kidney Dis. 2000 Jun; 35(6): 1242-7. PMID: 10845843, PII: S0272-6386(00)70066-7, ISSN: 1523-6838.

Fogo AB. Pathology of progressive nephropathies. Curr. Opin. Nephrol. Hypertens. 2000 May; 9(3): 241-6. PMID: 10847324, ISSN: 1062-4821.

Fogo AB. Glomerular hypertension, abnormal glomerular growth, and progression of renal diseases. Kidney Int. Suppl. 2000 Apr; 75: S15-21. PMID: 10828756, PII: kid7505, ISSN: 0098-6577.

Fogo AB. The role of angiotensin II and plasminogen activator inhibitor-1 in progressive glomerulosclerosis. Am. J. Kidney Dis. 2000 Feb; 35(2): 179-88. PMID: 10676714, PII: S0272-6386(00)70324-6, ISSN: 1523-6838.

Brown NJ, Nakamura S, Ma L-J, Nakamura I, Donnert E, Freeman M, Vaughan DE, Fogo AB. Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo. Kidney Int. 2000; 58: 1219-27.

Ma LJ, Nakamura S, Whitsitt JS, Marcantoni C, Davidson JM, Fogo AB. Regression of sclerosis in aging by an angiotensin inhibition- induced decrease in PAI-1. Kidney Int. 2000; 58: 2425-36.

Fogo AB. The role of angiotensin II and plasminogen activator inhibitor- 1 in progressive glomerulosclerosis. Am J Kidney Dis. 2000; 35: 179-88.

Miyazaki Y, Oshima K, Fogo A, Hogan BL, Ichikawa I. Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse urete. J Clin Invest. 2000; 105: 863-73.

Matsusaka T, Kon V, Takaya J, Katori H, Chen Xm, Miyazaki Ji, Homma T, Fogo A, Ichikawa I. : Dual renin gene targeting by Cre-mediated interchromosomal recombination. Genomics. 2000; 64: 127-31.

Nakamura S, Nakamura I, Ma LJ, Vaughan DE, Fogo AB. Plasminogen activator inhibitor-1 expression is regulated by the angiotensin type 1 receptor in vivo. Kidney Int. 2000; 58: 251-9.

Hoyer JR, Fogo AB, Terrell CH, Delaney MM. Immunomorphometric studies of proteinuria in individual deep and superficial nephrons of rats. Lab Invest. 2000; 80: 1691-700.

Fujinaka H, Miyazaki Y, Matsusaka T, Yoshida H, Fogo AB, Inagami T, Ichikawa I. Salutary role for angiotensin in partial urinary tract obstruction. Kidney Int. 2000; 58: 2018-27.

Fogo AB. Current concepts in glomerulosclerosis. Am. J. Kidney Dis. 1999 Nov; 34(5): liv-lvi. PMID: 10610618, PII: S0272-6386(99)70034-X, DOI: 10.1016/S0272-6386(99)70034-X, ISSN: 0272-6386.

Fogo AB. New insights into the renin-angiotensin system and hypertensive renal disease. Curr. Hypertens. Rep. 1999 Apr; 1(2): 187-94. PMID: 10981064, ISSN: 1522-6417.

Fogo AB. Mesangial matrix modulation and glomerulosclerosis. Exp. Nephrol. 1999 Mar; 7(2): 147-59. PMID: 10213868, PII: 20595, DOI: 20595, ISSN: 1018-7782.

Paueksakon P, Hunley TE, Lee SM, Fogo AB. A 12-year-old girl with pulmonary hemorrhage, skin lesions, and hematuria. Am. J. Kidney Dis. 1999 Feb; 33(2): 404-9. PMID: 10023658, PII: S0272-6386(99)70321-5, ISSN: 1523-6838.

Miyazaki Y, Tsuchida S, Fogo A, Ichikawa I. The renal lesions that develop in neonatal mice during angiotensin inhibition mimic obstructive nephropathy. Kidney Int. 1999; 55: 1683-95.

Matsusaka T, Katori H, Inagami T, Fogo A, Ichikawa I. Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice. J Clin Invest. 1999; 103: 1451-8.

Tsuchida S, Miyazaki Y, Matsusaka T, Hunley TE, Inagami T, Fogo A, Ichikawa I. Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculature. Kidney Int. 1999; 56: 509-16.

Mrukowicz JZ, Wetzel JD, Goral MI, Fogo AB, Wright PF, Dermody TS. Viruses and cells with mutations affecting viral entry are selected during persistent rotavirus infections of MA104 cells. J. Virol. 1998 Apr; 72(4): 3088-97. PMID: 9525634, PMCID: PMC109759, ISSN: 0022-538X.

Tsuchida S, Matsusaka T, Chen X, Okubo S, Niimura F, Nishimura H, Fogo A, Utsunomiya H, Inagami T, Ichikawa I. Murine double nullizygotes of the angiotensin type 1A and type 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest. 1998; 101: 755-60.

Okubo S, Niimura F, Matsusaka T, Fogo A, Hogan BLM, Ichikawa I. Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorption. Kidney Int. 1998; 53: 617-25.

Ma J, Nishimura H, Fogo A, Kon V, Inagami T, Ichikawa I. Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction. Kidney Int. 1998; 53: 937-44.

Miyazaki Y, Tsuchida S, Nishimura H, Pope JC IV, Harris RC, McKanna JM, Inagami T, Hogan BLM, Fogo A, Ichikawa I. Angiotensin induces the urinary peristaltic machinery during the perinatal period. J Clin Invest. 1998; 102: 1489-97.

Dunn NR, Winnier GE, Hargett LK, Schrick JJ, Fogo AB, Hogan BL. Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev. Biol. 1997 Aug 8/15/1997; 188(2): 235-47. PMID: 9268572, PII: S0012-1606(97)98664-4, DOI: 10.1006/dbio.1997.8664, ISSN: 0012-1606.

Wetzel JD, Chappell JD, Fogo AB, Dermody TS. Efficiency of viral entry determines the capacity of murine erythroleukemia cells to support persistent infections by mammalian reoviruses. J. Virol. 1997 Jan; 71(1): 299-306. PMID: 8985350, PMCID: PMC191051, ISSN: 0022-538X.

Nishimura H, Matsusaka T, Fogo A, Kon V, Ichikawa I. A novel in vivo mechanism for angiotensin type 1 receptor regulation. Kidney Int. 1997; 52: 345-55.

Oikawa T, Freeman M, Lo W, Vaughan DE, Fogo A. Modulation of plasminogen activator inhibitor-1 (PAI-1) in vivo: A new mechanism for the anti-fibrotic effect of renin-angiotensin inhibition. Kidney Int. 1997; 51: 164-72.

Okubo S, Niimura F, Nishimura H, Takemoto F, Fogo A, Matsusaka T, Ichikawa I. Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion. J Clin Invest. 1997; 855-860: 99.

Fogo A, Breyer JA, Smith MC, Cleveland WH, Agodoa L, Kirk KA, Glassock R. Accuracy of the diagnosis of hypertensive nephrosclerosis in African Americans- a report from the AASK trial. Kidney Int. 1997; 51: 244-52.

Niimura F, Okubo S, Fogo A, Ichikawa I. Temporal and spatial expression pattern of the angiotensinogen gene in mice and rats. Am J Physiol. 1997; R142-R147: 272.

Chen X, Li W, Yoshida H, Tsuchida S, Nishimura H, Takemoto F, Okubo S, Fogo A, Matsusaka T, Ichikawa I. Targeting deletion of angiotensin type 1B receptor gene in the mouse. Am J Physiol. 1997; 272: F299-F304.

Suzuki N, Labosky PA, Furuta Y, Hargett L, Dunn R, Fogo AB, Takahara K, Peters DM, Greenspan DS, Hogan BL. Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid. Development. 1996 Nov; 122(11): 3587-95. PMID: 8951074, ISSN: 0950-1991.

Hunley TE, Julian BA, Phillips JA, Summar ML, Yoshida H, Horn RG, Brown NJ, Fogo A, Ichikawa I, Kon V. Angiotensin converting enzyme gene polymorphism: Potential silencer motif and impact on progression in IgA nephropathy. Kidney Int. 1996; 571-577: 49.

Matsusaka T, Nishimura H, Utsunomiya H, Kakuchi J, Niimura F, Inagami T, Fogo A, Ichikawa I. Chimeric mice carrying "regional" targeted deletion of the angiotensin type 1a receptor gene: Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells. J Clin Invest. 1996; 98: 1867-77.

Ichiki, T., Labosky, P. A., Shiota, C., Okuyama, S., Imagawa, Y., Fogo, A., Miimura, F., Ichikawa, I., Hogan, B. L. M., Inagami, T. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature. 1995; 377: 748-50.

Teague MW, Glick AD, Fogo AB. Adenovirus infection of the kidney: mass formation in a patient with Hodgkin's disease. Am. J. Kidney Dis. 1991 Oct; 18(4): 499-502. PMID: 1928070, PII: S0272638691001890, ISSN: 0272-6386.

Motojima M, Nishijima F, Ikoma M, Kawamura T, Yoshioka T, Fogo AB, Sakai T, Ichikawa I. Role for "uremic toxin" in the progressive loss of intact nephrons in chronic renal failure. Kidney Int. 1991 Sep; 40(3): 461-9. PMID: 1787646, ISSN: 0085-2538.

Butler MG, Fogo AB, Fuchs DA, Collins FS, Dev VG, Phillips JA. Two patients with ring chromosome 15 syndrome. Am. J. Med. Genet. 1988 Jan; 29(1): 149-54. PMID: 3278612, DOI: 10.1002/ajmg.1320290119, ISSN: 0148-7299.